Compounds which potentiate glutamate receptor and uses thereof in medicine
Номер патента: EP1981864A1
Опубликовано: 22-10-2008
Автор(ы): Daniele Andreotti, Simon Edward Ward
Принадлежит: Glaxo Group Ltd
Опубликовано: 22-10-2008
Автор(ы): Daniele Andreotti, Simon Edward Ward
Принадлежит: Glaxo Group Ltd
Реферат: Compounds of formula (I), salts and solvates thereof are provided: wherein Ar is selected from phenyl, pyridyl, furanyl and thienyl, each optionally substituted with one or more groups Y; and each Y group is independently selected from the group consisting of: halo, C1-4alkyl, haloC1-4alkyl, C1-4alkoxy, cyano, C(O) C1-4alkyl, NHSO2C1-4alkyl, NMeSO2C1-4alkyl, NHCOC1-4alkyl, NMeCOC1-4aIkyl, SOC1-4alkyl, SO2C1-4alkyl, and CO2C1-4alkyl, or two Y groups together form a cyclic group -0(CH2)O-. Processes for preparation, and uses thereof in the treatment of a disease or condition mediated by a reduction or imbalance in glutamate receptor function, such as schizophrenia or cognition impairment, are also disclosed.
Compounds which potentiate glutamate receptor and uses thereof in medicine
Номер патента: WO2007090841A1. Автор: Daniele Andreotti,Simon Edward Ward. Владелец: Glaxo Group Limited. Дата публикации: 2007-08-16.