Method of determining, identifying or isolating cell-penetrating peptides
Номер патента: CA2834577A1
Опубликовано: 29-11-2012
Автор(ы): Katrin Hoffman, Paul Michael Watt, Richard Hopkins
Принадлежит: Phylogica Ltd
Опубликовано: 29-11-2012
Автор(ы): Katrin Hoffman, Paul Michael Watt, Richard Hopkins
Принадлежит: Phylogica Ltd
Реферат: The present invention provides a method of determining or identifying or isolating a cell-penetrating peptide (CPP) or analog or derivative thereof having cell-type selectivity and/or at least capable of passing through a Blood Brain Barrier of an animal subject. This invention also provides CPPs and analogs and derivatives thereof, such as those set forth in SEQ ID NOs: 1-27 of the Sequence Listing, and compositions comprising one or more of the CPPs, including conjugates in which a CPP or analog or derivative thereof is linked to a cargo molecule. The invention also provides methods for transporting cargo molecules across cell membranes to specific locations within cells, and for treating, preventing and/or diagnosing diseases that are treatable by a cargo molecule to which a CPP or analog or derivative of the invention is attached. The invention also provides tailored peptide libraries for use in identifying or isolating CPPs.
Method of determining, identifying or isolating cell-penetrating peptides
Номер патента: EP2714971A1. Автор: Paul Michael Watt,Richard Hopkins,Katrin Hoffman. Владелец: Phylogica Ltd. Дата публикации: 2014-04-09.