Isoxazolylacetamido penicillanic and cephalosporanic acids - partic. active against Gram-positive bacteria
Реферат: Derivatives of formula (I) (where Q is a group of formula (II), (III) or (IV) in which X is H, OH, lower alkanoyloxy or the residue of a nucleophilic agent and E is H, a salt-forming cation or a pharmaceutically tolerable ester residue; R is OH, OCH3 Cl or Br; R1 is H, Cl or Br; and R2 is H, Cl, Br, amino, lower alkoxycarbonylamino, phenyl(lower alkoxy)carbonylamino, p-nitro- or p-methoxyphenyl(lower alkoxy)carbonylamino, a sulphonic acid group or its alkali(ne earth) metal or amine salt, or a carbamoyl group) are antibiotics particularly active against gram-positive organisms. They also have good activity against penicillin-resistant staphylococci and gram-negative organisms (Pasteurella multocida, Klebsiella pneumoniae, Salmonella Dublin). They can thus be used as medicinal agents; they may also be used as growth promoters for ruminants.
O-desacetyl-7-n-acylamino-cephalosporanic acids and process for their manufacture
Номер патента: GB1287786A. Автор: . Владелец: Ciba Geigy AG. Дата публикации: 1972-09-06.