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Methods, compositions and kits for treating or preventing a disease associated with Gram-negative bacteria

Номер патента: US20140010824A1
Опубликовано: 09-01-2014
Автор(ы): Erin R. Green, Gregory T. Crimmins, Joan Mecsas, Ralph R. Isberg, Sina Mohammadi
Принадлежит: TUFTS UNIVERSITY
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Methods, compositions and kits for treating or preventing a disease associated with Gram-negative bacteria

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Compositions and methods for treating or ameliorating a mycobacterium tuberculosis infection

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Genetic test for detecting a predisposition to a disease associated with abnormal vegf gene expression

Номер патента: EP1200621A2. Автор: Paul Ernest Charles Brenchley,Carolyn Watson. Владелец: Victoria University of Manchester. Дата публикации: 2002-05-02.

Compositions comprising urolithin for treating muscle decline and a kidney dysfunction

Номер патента: CA3237948A1. Автор: Jerome FEIGE,Maximilian von EYNATTEN,Claudia Roessle,Vincenzo Sorrentino,Sonia KARAZ. Владелец: SOCIETE DES PRODUITS NESTLE SA. Дата публикации: 2023-06-29.

Compositions comprising urolithin for treating muscle decline and a kidney dysfunction

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Genetic test for detecting a predisposition to a disease associated with abnormal vegf gene expression

Номер патента: WO2001004351A3. Автор: Paul Ernest Charles Brenchley,Carolyn Watson. Владелец: Carolyn Watson. Дата публикации: 2001-08-09.

New inhibitors for treating diseases associated with an excess transport of hyaluronan

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THE USE OF PORCINE β-DEFENSIN FOR TREATING OR PEVENTING A MICROBIAL INFECTION IN A VERTEBRATE SUBJECT

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New inhibitors for treating diseases associated with an excess transport of hyaluronan

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New inhibitors for treating diseases associated with an excess transport of hyaluronan

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New inhibitors for treating diseases associated with an excess transport of hyaluronan

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Cox-2 selective carprofen for treating pain and inflammation in dogs

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Treatment of a disease or a condition associated with aberrant gene hypomethylation by a method involving tailored epigenomic modification

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Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases

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Atxn2 irna compositions and methods of use thereof for treating or preventing atxn2-associated neurodegenerative diseases

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Faecalibacterium prausnitzii and desulfovibrio piger for use in treatment or prevention of diabetes and intestinal diseases

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Irak inhibitor for treating cytokine release-related conditions associated with infection by a respiratory virus

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Methods for treating atherosclerotic cardiovascular disease with lpa-targeted rnai constructs

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Heterocyclic compounds and use thereof in treating or preventing bacterial infections

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Composition and method for treating muscle decline associated with renal disease or dysfunction

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Composition and method for treating muscle decline associated with renal disease or dysfunction

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Therapeutic agent comprising a B-subunit of a protein toxin in conjunction with EBV latent mambrane protein useful for the treatment of diseases associated with the Epstein Barr Virus and neoplasias

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Intestinal organoid co-culture systems and methods for treating or preventing a disease or disorder associated with immune response-mediated tissue injury

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Compositions and methods for the treatment and prevention of gram-negative bacterial infections

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Methods of treating, ameliorating and/or preventing fibrodysplasia ossificans progressiva and heterotopic ossification, and kits for the same

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Pharmaceutical composition for treating cognitive decline or for treating overweightness or obesity

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Compositions and methods for targeted protein stabilization by redirecting endogenous deubiquitinases

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Polymer-based antimicrobial compositions and a method for use thereof

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Methods and compositions for treating amyloid-related diseases

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Treatment of diseases associated with reductive stress

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Methods for treating or preventing viral infection

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Mirna molecule, equivalent, antagomir, or source thereof for treating and/or diagnosing a condition and/or a disease associated with neuronal deficiency or for neuronal (re)generation

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Complement factor i-related compositions and methods

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Compositions and methods for genetically-encoded high voltage-activated calcium channel blockers using engineered ubiquitin ligases

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Compositions and methods for genetically-encoded high voltage-activated calcium channel blockers using engineered ubiquitin ligases

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Methods of treating diseases associated with elevated uric acid

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Amiselimod for preventing, treating or ameliorating ulcerative colitis

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Complement factor I-related compositions and methods

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Complement factor i-related compositions and methods

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Method and device for treating a teat canal of an animal

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Method and device for treating a teat canal of an animal

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Methods and compositions for treating amyloid-related diseases

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Analogues of pentamidine and methods for treating infections

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Analogues of pentamidine and methods for treating infections

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Composition and method for detection and early and differential calculation of gram-negative microorganisms

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Agent for treating human body conditions associated with a decrease in the level of expression of the prok 2 gene and/or a decrease in the amount of prokineticin 2 protein on the basis of gene-therapeutic substances with prok 2 gene, method for obtaining and using

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Estrogen agonist/antagonist and statin containing compositions for treating osteoporosis and lowering cholesterol

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Anticancer compositions and methods for making and using them

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Composition and method for new therapeutic agents including guanidinium-presenting dendrimers and branched structures

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Low dose pridopidine for parkinson's disease and other diseases associated with parkinsonism

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Anticancer compositions and methods for making and using them

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Composition and method for new therapeutic agents including guanidinium-presenting dendrimers and branched structures

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Compositions and methods for treating neurodegenerative conditions

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Biologic-chemical herbicide compositions and methods of use

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Biologic-chemical herbicide compositions and methods of use

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Monoglyceride compositions and their use against helicobacter

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Products and methods for treating muscular dystrophy

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Compositions and Methods for Inhibition of L-Plastin Activity in Osteoclasts to Reduce Bone Loss

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Products and methods for treating muscular dystrophy

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Oligonucleotide for detection of bacteria associated with sepsis and microarrays and a methods for detection of the bacteria using the oligonucleotide

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Amyloid beta fibril decomposing agent, and therapeutic or preventive agent and therapeutic or preventive food composition for diseases caused by amyloid beta fibril formation

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Use of moclobemide and metabolites for treating and preventing substance abuse

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Compounds, compositions and methods for treating or preventing a symptom associated with gout or hyperuricemia

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Methods for treating cancers and tumors

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Bisphosphonate compositions and methods for treating and\or reducing cardiac dysfunction

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Artificial saliva containing amino acid and using basic amino acid for treating dry mouth

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Methods for treating inflammatory diseases and pharmaceutical combinations useful therefor

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Dendrimer compositions and methods for treatment of peroxisomal disorders and leukodystrophies

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Perk inhibitors and uses thereof in treating diseases associated with aggregation-prone proteins

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Amyloid beta fibril decomposing agent, and therapeutic or preventive agent and therapeutic or preventive food composition for diseases caused by amyloid beta fibril formation

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Compositions and methods for treating sars-cov-2 infection

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Compositions and methods for treating or preventing radiation injury

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Method for treating kidney disorders

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pharmaceutical composition for treating cocaine addiction or preventing relapse of cocaine addiction, methods for treating cocaine addiction and for preventing cocaine addiction relapse, use of (r) -2- {3- [1- (5 -methyl-1,2,3,4-tetrahydronaphthalen-1-yl) piperidin-4-yl] -2,3-dihydro-2-oxo-benzimidazol-1-yl} -n-methylacetamide or a pharmaceutically acceptable salt thereof, and, (r) -2- {3- [1- (5-methyl-1,2,3,4-tetrahydronaphthalen-1-yl) piperidin-4-yl] -2, 3-dihydro-2-oxo-benzimidazol-1-yl} -n-methylacetamide or a pharmaceutically acceptable salt thereof.

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pharmaceutical composition; method for treating or prophylaxis of a viral infection or disease associated therewith; compound; a method for preparing a mixture of tert-butyl (4e) -4- (hydroxymethylene) -5-oxoazepane-1-carboxylate and tert-butyl (3e) -3- (hydroxymethylene) -4-oxoazepane-1-carboxylate; method for the preparation of a mixture of tert-butyl 3-cyano-2-thioxo-1,2,5,6,8,9-hexahydro-1h-pyrido [2,3-d] azepine-7-carboxylate and tert butyl 3-cyano-2-thioxo-1,2,5,7,8,9-hexahydro-6h-pyrido [3,2-c] azepine-6-carboxylate; Method for the preparation of 3-amino-7-tert-butyloxycarbonyl-6,7,8,9-tetrahydro-5h-1-thia-7,10-diaza-cyclohepta [f] indene-2-carboxylic acid (5- phenyl- [1,3,4] thiazol-2-yl) -amide; method for the preparation of 3-amino-6,7,8,9-tetrahydro-5h-1-thia-7,10-diaza-cyclohepta [f] indene-2-carboxylic acid (5-phenyl- [1,3 , 4] thiadiazol-2-yl) -amide; Method for the preparation of 3-amino-6-tertbutyloxycarbonyl-6,7,8,9-tetrahydro-5h-1-thia-6,10-diaza-cyclohepta [f] indene-2-carboxylic acid [1,3,4] thiadiazol-2-yl) -amide and method for the preparation of 3-amino-6,7,8,9-tetrahydro-5h-1-thia-6,10-diaza-cyclohepta acid [ f] indene-2-carboxylic (5-phenyl- [1,3,4] thiadiazol-2-yl) -amide

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Prodrug compound of a compound originating from pharmaceutical composition processes to antagonize the effect of substance p at its receptor site or to block neurokinin-1 receptors in a mammal to treat or prevent pain or nociception attributable to or associated with migraine a condition selected from the group consisting of of AIDS-related peripheral diabetic neuropathy induced by chemotherapy and neuralgia asthma emesis and arthritis to treat cystic fibrosis and process to prepare

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POLYMIXIN DERIVATIVE OF THE GENERAL FORMULA (I); COMBINATION PRODUCT; PHARMACEUTICAL COMPOSITION; METHOD FOR THE TREATMENT, RELIEF OR IMPROVEMENT OF AN INFECTION, IN A PATIENT, CAUSED BY A GRAM-NEGATIVE BACTERIA; METHOD FOR SENSITIZING GRAM-NEGATIVE BACTERIA TO AN ANTIBACTERIAL AGENT; METHOD FOR THE DEVELOPMENT OF UNPUBLISHED ANTIBIOTICS; METHODS FOR REDUCING THE TOXICITY OF POLYMIXINS, NATURAL OCTAPEPTINS AND THEIR DERIVATIVES DURING THE APPLICATION OF THE SAME IN THE TREATMENT OF INFECTIONS IN AN INDIVIDUAL; METHOD TO IMPROVE PHARMACOKINETIC PROPERTIES, OF POLYMIXINS, NATURAL OCTAPEPTINS AND THEIR DERIVATIVES; METHOD FOR THE AWARENESS OF CLINICALLY IMPORTANT GRAM-NEGATIVE BACTERIA TO A DEFENSE MECHANISM COMPLEMENT IN THE SERUM; USE OF A DERIVATIVE; AND PROCESS FOR THE PREPARATION OF A POLYMIXIN DERIVATIVE OF FORMULA (I)

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PROCEDURE FOR OBTAINING PENICILLINIC SUBSTANCES WITH A WIDE SPECTRUM AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA.

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Attenuated gram negative bacteria

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Nutritional or dietary supplement composition and methods for using same for treating visual acuity loss

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