RET-INHIBITOR COMPOUNDS, PHARMACEUTICAL COMPOSITION AND USES OF SUCH COMPOUNDS .

RET-INHIBITOR COMPOUNDS, PHARMACEUTICAL COMPOSITION AND USES OF SUCH COMPOUNDS

Номер патента: BR112018008877B1
Опубликовано: 24-01-2023
Автор(ы): Douglas Wilson, Jason D. Brubaker, Joseph L. Kim, Kevin J. Wilson, Lucian V. Dipietro
Принадлежит: BLUEPRINT MEDICINES CORPORATION
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Рисунок 1. Взаимосвязь патентов (ближайшие 20).

HEREROCICLIC PIRROLIDINS AGONISTS OF MELANOCORTINE RECEPTORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME IN THE TREATMENT OF OBESITY, DIABETES AND ERECTILE DYSFUNCTION.

Номер патента: AR074109A1. Автор: Koo Lee,Sung-Pil Choi,Sang Dae Lee,Hyun Min Lee,In Ae Ahn,Dong Sup Shim,Soo Yong Chung,Sang Pil Moon. Владелец: LG Life Sciences Ltd. Дата публикации: 2010-12-22.

Parp inhibitor, pharmaceutical composition comprising same, and use thereof

Номер патента: AU2022411308A1. Автор: Yuan Tian,Yongqi Deng,Shijun ZHU,Yanlin JIA. Владелец: Keythera Suzhou Bio Pharmaceuticals Co Ltd. Дата публикации: 2024-08-01.

Parp inhibitor, pharmaceutical composition comprising same, and use thereof

Номер патента: EP4450498A1. Автор: Yuan Tian,Yongqi Deng,Shijun ZHU,Yanlin JIA. Владелец: Keythera Suzhou Bio Pharmaceuticals Co Ltd. Дата публикации: 2024-10-23.

Parp inhibitor, pharmaceutical composition comprising same, and use thereof

Номер патента: CA3241338A1. Автор: Yuan Tian,Yongqi Deng,Shijun ZHU,Yanlin JIA. Владелец: Keythera Suzhou Bio Pharmaceuticals Co Ltd. Дата публикации: 2023-06-22.

Indole derivatives, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating or preventing diseases associated with modulation of h3 receptors

Номер патента: IL179737A. Автор: . Владелец: Hoffmann La Roche. Дата публикации: 2011-12-29.

P2X3 andor P2X2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof

Номер патента: US11919918B2. Автор: Gong Li,Xiang Li,Kai Liu,Hongjun Wang,Yanping Zhao,Yuanyuan JIANG,Yeming Wang,Liying Zhou,Yanan Liu,Ning SHAO,Fengping XIAO. Владелец: Beijing Tide Pharmaceutical Co Ltd. Дата публикации: 2024-03-05.

P2X3 and/or P2X2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof

Номер патента: AU2018361276A1. Автор: Gong Li,Xiang Li,Kai Liu,Hongjun Wang,Yanping Zhao,Yuanyuan JIANG,Yeming Wang,Liying Zhou,Yanan Liu,Ning SHAO,Fengping XIAO. Владелец: Beijing Tide Pharmaceutical Co Ltd. Дата публикации: 2020-05-14.

P2x3 and/or p2x2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof

Номер патента: US20210179648A1. Автор: Gong Li,Xiang Li,Kai Liu,Hongjun Wang,Yanping Zhao,Yuanyuan JIANG,Yeming Wang,Liying Zhou,Yanan Liu,Ning SHAO,Fengping XIAO. Владелец: Beijing Tide Pharmaceutical Co Ltd. Дата публикации: 2021-06-17.

P2x3 and/or p2x2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof

Номер патента: EP3712144A1. Автор: Gong Li,Xiang Li,Kai Liu,Hongjun Wang,Yanping Zhao,Yuanyuan JIANG,Yeming Wang,Liying Zhou,Yanan Liu,Ning SHAO,Fengping XIAO. Владелец: Beijing Tide Pharmaceutical Co Ltd. Дата публикации: 2020-09-23.

Parp-1 degradation agent and use thereof

Номер патента: EP4421074A1. Автор: Yao Li,Chen Zhang,Yan Yu,Lei Chen,Gang Hu,Haodong WANG,Hao Yao,Pingming Tang,Pangke Yan,Tiancheng HE,Pengxin GENG,Linyong FANG. Владелец: Xizang Haisco Pharmaceutical Co Ltd. Дата публикации: 2024-08-28.

Analogs of yohimbine and uses thereof

Номер патента: US20190256490A1. Автор: Hendrik Luesch,Robert William Huigens, III,Nicholas G. Paciaroni. Владелец: University of Florida Research Foundation Inc. Дата публикации: 2019-08-22.

Compounds inhibiting rip2 kinase, pharmaceutical composition based thereon and use thereof for the treatment of diseases mediated by rip2 kinase

Номер патента: EA033343B1. Автор: Линда Н. Касиллас,Джон Дэвид Харлинг,Афджал Хуссайн Миах,Марк Дэвид Рэкхэм,Иан Эдвард Дэвид Смит. Владелец: Глаксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед. Дата публикации: 2019-09-30.

Derivatives of piperazine, pharmaceutical compositions containing thereof and using as ccr5 antagonists

Номер патента: RU2299206C2. Автор: Элизабет М. СМИТ,Анандан ПАЛАНИ,Майкл В. МИЛЛЕР,Бахидж М. БЭРОУДИ,Джон В. КЛЭДЕР,Убер Б. ЖОЗЬЕН,Стюарт В. МАККОМБИ,Брайан А. МАККИТРИК,Бернард Р. НЬЮСТЭДТ,Руо СТИНСМА,Йайарам Р. ТЭГЕТ,Сьюзан Ф. ВАЙС,Марк А. ЛАФЛИНГ,Эрик ГИЛБЕРТ,Марк А. ЛЭБРОЛИ,Элизабет М. СМИТ (US),Майкл В. МИЛЛЕР (US),Анандан ПАЛАНИ (US),Бахидж М. БЭРОУДИ (US),Джон В. КЛЭДЕР (US),Убер Б. ЖОЗЬЕН (US),Стюарт В. МАККОМБИ (US),Брайан А. МАККИТРИК (US),Бернард Р. НЬЮСТЭДТ (US),Руо СТИНСМА (US),Йайарам Р. ТЭГЕТ (US),Сьюзан Ф. ВАЙС (US),Марк А. ЛАФЛИНГ (US),Эрик ГИЛБЕРТ (US),Марк А. ЛЭБРОЛИ (US). Владелец: Шеринг Корпорейшн. Дата публикации: 2007-05-20.

Derivatives of piperazine, pharmaceutical compositions containing thereof and using as ccr5 antagonists

Номер патента: RU2299206C9. Автор: Элизабет М. СМИТ,Анандан ПАЛАНИ,Майкл В. МИЛЛЕР,Бахидж М. БЭРОУДИ,Джон В. КЛЭДЕР,Убер Б. ЖОЗЬЕН,Стюарт В. МАККОМБИ,Брайан А. МАККИТРИК,Бернард Р. НЬЮСТЭДТ,Руо СТИНСМА,Йайарам Р. ТЭГЕТ,Сьюзан Ф. ВАЙС,Марк А. ЛАФЛИНГ,Эрик ГИЛБЕРТ,Марк А. ЛЭБРОЛИ. Владелец: Шеринг Корпорейшн. Дата публикации: 2007-11-20.

Amorphous substances, crystals, pharmaceutical compositions, preparation methods and uses of thiohydantoin compound or pharmaceutically acceptable salt thereof

Номер патента: EP4400498A1. Автор: Youzhi Tong,Chun Deng. Владелец: Suzhou Kintor Pharmaceuticals Inc. Дата публикации: 2024-07-17.

Naphthalene ring-containing compound, pharmaceutical composition containing same, and use thereof

Номер патента: EP4339181A1. Автор: CHEN ZHOU,Yijun Deng,Liang Wu,Tielin Wang,Zhenhua HE,Qiaoling Sun. Владелец: Asieris Pharmaceuticals Shanghai co ltd. Дата публикации: 2024-03-20.

Naphthalene ring-containing compound, pharmaceutical composition containing same, and use thereof

Номер патента: US20240131168A1. Автор: CHEN ZHOU,Yijun Deng,Liang Wu,Tielin Wang,Zhenhua HE,Qiaoling Sun. Владелец: Asieris Pharmaceuticals Shanghai co ltd. Дата публикации: 2024-04-25.

Derivatives of pyrimidine, pharmaceutical composition, inhibition method and using

Номер патента: RU2288227C2. Автор: Нобуюки ЯСУДА,Хитоси ХАРАДА,Осаму АСАНО,Сухеи МИЯЗАВА,Масато УЕДА,Масахиро ЯСУДА,Йосихико КОТАКЕ,Ясухиро КАБАСАВА,Даисуке ИЙДА,Дзунити НАГАКАВА,Казуо ХИРОТА,Макото НАКАГАВА. Владелец: Эйсай Ко., Лтд.. Дата публикации: 2006-11-27.

Shp2 inhibitor, pharmaceutical composition comprising same, and use thereof

Номер патента: EP4417600A1. Автор: Peng Lu,Yu Zhang,Ning Wang,Xiaobo Li,Wenming Li,Junrong Liu,Guokun Yu,Tiantian Yu,Mingnan PIAO. Владелец: Beijing Tide Pharmaceutical Co Ltd. Дата публикации: 2024-08-21.

6-phenylpyridyl-2-amine derivatives, pharmaceutical compositions containing them and uses thereof in the preparation of a composition for inhibiting nos

Номер патента: IL125811A. Автор: . Владелец: Pfizer. Дата публикации: 2003-01-12.

P2x3 and/or p2x2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof

Номер патента: EP3712144C0. Автор: Gong Li,Xiang Li,Kai Liu,Hongjun Wang,Yanping Zhao,Yuanyuan JIANG,Yeming Wang,Liying Zhou,Yanan Liu,Ning SHAO,Fengping XIAO. Владелец: Beijing Tide Pharmaceutical Co Ltd. Дата публикации: 2024-02-14.

Compounds derived from pyrrole [3,4-b] pyridin-5-one, inhibitors of pi3k; pharmaceutical composition comprising them; and use for the treatment of diseases such as Alzheimer's, epilepsy, multiple sclerosis, Parkinson's, among others.

Номер патента: CL2012001714A1. Автор: Jian Wang,David Messersmith,Jingrong Cao,Suganthini Nanthakumar,Alex Aronov,Albert C Pierce,Upul K Bandarage,Robert J Davies,Yusheng Liao,Jon H Come,Elaine Krueger,Amaud Le Tiran. Владелец: Vertex Pharma. Дата публикации: 2013-04-12.

P2x3 and/or p2x2/3 receptor antagonist, pharmaceutical composition comprising same, and use thereof

Номер патента: EP3712144B1. Автор: Gong Li,Xiang Li,Kai Liu,Hongjun Wang,Yanping Zhao,Yuanyuan JIANG,Yeming Wang,Liying Zhou,Yanan Liu,Ning SHAO,Fengping XIAO. Владелец: Beijing Tide Pharmaceutical Co Ltd. Дата публикации: 2024-02-14.

Novel indole derivative, pharmaceutical composition comprising same, and use thereof

Номер патента: EP4382523A1. Автор: Soon Ha Kim,Jae Young Kim,Mooyoung SEO,Hye Kyung Chang,Jin Sung Park,HyunJun Park,Jeong-Hee Yang,Eun Kyung YOO,Kyung Kuk JANG,Jeong Hyang Park,Yun Min Park,Yewon YUN. Владелец: Mitoimmune Therapeutics Inc. Дата публикации: 2024-06-12.

Derivatives of hexahydrodiazepinone, pharmaceutical composition containing thereof and using in preparing medicinal agent for treatment of non-insulin dependent diabetes mellitus

Номер патента: RU2301803C2. Автор: Тесфайе БИФТУ,Гуй-Бай ЛЯНГ,С ос ЦЯНЬ,Сяося ЦЯНЬ,Энн Э. УЭБЕР,Данцин Деннис ФЭН. Владелец: Мерк Энд Ко., Инк.. Дата публикации: 2007-06-27.

Novel indole derivative, pharmaceutical composition comprising same, and use thereof

Номер патента: AU2022324177A1. Автор: Soon Ha Kim,Jae Young Kim,Mooyoung SEO,Hye Kyung Chang,Jin Sung Park,HyunJun Park,Jeong-Hee Yang,Eun Kyung YOO,Kyung Kuk JANG,Jeong Hyang Park,Yun Min Park,Yewon YUN. Владелец: Mitoimmune Therapeutics Inc. Дата публикации: 2024-02-22.

Non-imidazole compounds, pharmaceutical composition comprising same and use thereof

Номер патента: SK4672003A3. Автор: Pietro Mangiaracina,Neng-Yang Shih,John J Piwinski,Stuart B Rosenblum,Christopher W Boyce,Robert G Aslanian,Pauline C Ting,Wing C Tom,Michael Y Berlin,Mwangi Wa Mutahi,Cormick Kevin D Mc. Владелец: Schering Corp. Дата публикации: 2003-11-04.

DIAZOLIC AND / OR TRIAZOLIC DERIVATIVES OF AGGRISTS OF TGR5 RECEPTORS COUPLED TO PROTEIN G, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME IN THE TREATMENT OF OBESITY, DIABETES AND OTHER METABOLIC DISORDERS.

Номер патента: AR075255A1. Автор: . Владелец: Exelixis Inc. Дата публикации: 2011-03-16.

1-heterocyclylsulfonyl-3-aminomethyl, 5-(hetero)aryl substituted 1-h-pyrrole derivatives as acid secretion inhibitors, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments

Номер патента: IL189375A. Автор: . Владелец: Takeda Pharmaceutical. Дата публикации: 2013-05-30.

SUBSTITUTED IMIDAZOLES, PHARMACEUTICAL COMPOSITION THAT UNDERSTANDS THEM, THE USE OF THE SAME IN THE MANUFACTURE OF A MEDICINAL PRODUCT AND PROCEDURE FOR SUPREPARATION AND INTERMEDIARY

Номер патента: AR012594A1. Автор: . Владелец: Ortho Mcneil Pharm Inc. Дата публикации: 2000-11-08.

Carboxamide compounds and use thereof as calpain inhibitors

Номер патента: RU2485114C2. Автор: Хельмут Мак,Андреас КЛИНГ,Вильфрид ХОРНБЕРГЕР,Вильфрид ЛУБИШ,Ахим МЁЛЛЕР,Фолькер НИММРИХ,Дитмар ЗЕЕМАНН. Владелец: Эбботт Гмбх Унд Ко.Кг. Дата публикации: 2013-06-20.

Benzodiazepine compound and pharmaceutical composition

Номер патента: RU2496775C2. Автор: Кунио ОСИМА,Синити ТАИРА,Кунинори ТАИ,Ясухиро МЕНДЗО,Ясуо КОГА,Такаси ОСИЯМА,Хокуто ЯМАБЕ,Суудзи МАЦУМУРА,Масатака УЕДА,Сунао НАКАЯМА,Тосиюки ОНОГАВА,Кендзи ЦУДЗИМАЕ. Владелец: Оцука Фармасьютикал Ко., Лтд. Дата публикации: 2013-10-27.

METALOPROTEINASE INHIBITING COMPOUNDS, PHARMACEUTICAL COMPOSITION, TREATMENT METHOD, AND USE OF THESE COMPOUNDS FOR THE PREPARATION OF MEDICINES

Номер патента: AR035695A1. Автор: . Владелец: AstraZeneca AB. Дата публикации: 2004-06-23.

4,5,6-trisubstituted pyrimidine compounds, pharmaceutical compositions containing them and use thereof in the preparation of medicaments for modulating metabolism

Номер патента: IL169081A. Автор: . Владелец: Arena Pharm Inc. Дата публикации: 2012-07-31.

Deuterated 3-cyano quinoline compound, pharmaceutical composition, preparation method and use thereof

Номер патента: WO2014086284A1. Автор: 李萍,万惠新,沈竞康,刘海燕,李春丽,陈岗,徐佳,李玉峰,韩雅男,周兆丽. Владелец: 上海医药集团股份有限公司. Дата публикации: 2014-06-12.

N-cyclopropyl-N-piperidinyl-amides, pharmaceutical compositions containing them, and uses thereof

Номер патента: US09469631B2. Автор: Armin Heckel,Frank Himmelsbach,Nicole Harriott,Andreas Blum,Neil J. Ashweek,Bernd Nosse. Владелец: BOEHRINGER INGELHEIM INTERNATIONAL GMBH. Дата публикации: 2016-10-18.

Heterocyclic compound, preparation method and use thereof

Номер патента: US20230331710A1. Автор: Chaodong Wang,Yongkai CHEN,Linbo LUAN. Владелец: SHANGHAI MEIYUE BIOTECH DEVELOPMENT CO LTD. Дата публикации: 2023-10-19.

HETEROCICLIC PIPERIDINIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE OF THE SAME FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Номер патента: AR088226A1. Автор: Yoshikawa Masato,Kamisaki Haruhi,Koike Tatsuki,John Farnaby William. Владелец: Takeda Pharmaceutical. Дата публикации: 2014-05-21.

Arylamines useful for the treatment of conditions associated with gsk-3, process for producing them, pharmaceutical compositions containing them and use thereof

Номер патента: HU0500339A2. Автор: Stefan Berg,Sven Hellberg. Владелец: Astrazeneca Ab,. Дата публикации: 2005-07-28.

Ketohexokinase inhibitor and use thereof

Номер патента: EP4269404A1. Автор: Yao Li,Chen Zhang,Yan Yu,Lei Chen,Yajun Wang,Xiaobo Zhang,Guobiao Zhang,Gang Hu,Haodong WANG,Pingming Tang,Pangke Yan,Wenjing Wang. Владелец: Sichuan Haisco Pharmaceutical Co Ltd. Дата публикации: 2023-11-01.

Ketohexokinase inhibitor and use thereof

Номер патента: US20240067633A1. Автор: Yao Li,Chen Zhang,Yan Yu,Lei Chen,Yajun Wang,Xiaobo Zhang,Guobiao Zhang,Gang Hu,Haodong WANG,Pingming Tang,Pangke Yan,Wenjing Wang. Владелец: Xizang Haisco Pharmaceutical Co Ltd. Дата публикации: 2024-02-29.

N-cyclopropyl-N-piperidinyl-amide, pharmaceutical compositions containing them and uses thereof

Номер патента: JP6263789B2. Автор: ヒンメルスバッハフランク,フランクヒンメルスバッハ,ベルントノゼ,ニールジェイアシュウィーク,ニールジェイアシュウィーク,ニコルハリオット,アルミンヘッケル,アンドレアスブルム,ヘッケル　アルミン. Владелец: ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング. Дата публикации: 2018-01-24.

DERIVATIVES OF N-FENIL PIRAZOL AND PIRIDIL PIRAZOLES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEMSELVES AND USES AS ANTIAGREGATING PLATQUETARY AND ANTHROMBROTIC AGENTS.

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Pyridine derivatives pharmaceutical compositions comprising the same the use of the same for the manufacture of medicaments having therapeutic or preventative value and a process for preparing the same

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Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same

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Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same

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New isoindoline derivative, pharmaceutical composition including thereof and use thereof

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N-(benzoyl)-phenylalanine compound, pharmaceutical composition containing same, and use thereof

Номер патента: EP4282865A1. Автор: Weiqiang Zhan,Zhanguo Wang,Jianbo Wu,Fanglei CHEN,Fangmeng ZHU,Fengming Yang. Владелец: Hangzhou Apeloa Medicine Research Institute Co Ltd. Дата публикации: 2023-11-29.

N-(benzoyl)-phenylalanine compound, pharmaceutical composition containing same, and use thereof

Номер патента: US20240150287A1. Автор: Weiqiang Zhan,Zhanguo Wang,Jianbo Wu,Fanglei CHEN,Fangmeng ZHU,Fengming Yang. Владелец: Hangzhou Apeloa Medicine Research Institute Co Ltd. Дата публикации: 2024-05-09.

N-(benzoyl)-phenylalanine compound, pharmaceutical composition containing same, and use thereof

Номер патента: AU2021422269A1. Автор: Weiqiang Zhan,Zhanguo Wang,Jianbo Wu,Fanglei CHEN,Fangmeng ZHU,Fengming Yang. Владелец: Hangzhou Apeloa Medicine Research Institute Co Ltd. Дата публикации: 2023-08-10.

N-(benzoyl)-phenylalanine compound, pharmaceutical composition containing same, and use thereof

Номер патента: CA3205764A1. Автор: Weiqiang Zhan,Zhanguo Wang,Jianbo Wu,Fanglei CHEN,Fangmeng ZHU,Fengming Yang. Владелец: Hangzhou Apeloa Medicine Research Institute Co Ltd. Дата публикации: 2022-07-28.

N-(benzoyl)-phenylalanine compound, pharmaceutical composition containing same, and use thereof

Номер патента: AU2021422269B2. Автор: Weiqiang Zhan,Zhanguo Wang,Jianbo Wu,Fanglei CHEN,Fangmeng ZHU,Fengming Yang. Владелец: Hangzhou Apeloa Medicine Research Institute Co Ltd. Дата публикации: 2024-02-08.

N-cyclopropyl-N-piperidinyl-amides, pharmaceutical compositions containing them and uses thereof

Номер патента: US09926308B2. Автор: Frank Himmelsbach,Matthias Eckhardt,Elke Langkopf,Nicole Harriott,Neil J. Ashweek,Bernd Nosse. Владелец: BOEHRINGER INGELHEIM INTERNATIONAL GMBH. Дата публикации: 2018-03-27.

Novel octahydrothienoquinoline derivative, pharmaceutical composition comprising derivative, and use of these

Номер патента: NZ615293A. Автор: Kiyoshi Kasai,Toshihiro Nishimura,Yasunori Ueno,Masako Yoshida,Hirotaka Teranishi. Владелец: Kissei Pharmaceutical. Дата публикации: 2014-08-29.

N-cyclopropyl-n-piperidinyl-amides, pharmaceutical compositions containing them and uses thereof

Номер патента: US20160159784A1. Автор: Frank Himmelsbach,Matthias Eckhardt,Elke Langkopf,Nicole Harriott,Neil J. Ashweek,Bernd Nosse. Владелец: BOEHRINGER INGELHEIM INTERNATIONAL GMBH. Дата публикации: 2016-06-09.

4-[(4-methyl-1-piperazinyl)-methyl]-n-{4-methyl-3[[4-(1-oxido-3-pyridinyl)-2-pyrimidinyl]-amino]-phenyl}-benzamide,pharmaceutical compositions comprising it and use thereof for the preparation of a pharmaceutical composition for the treatment of a proliferative disorder

Номер патента: IL208399A. Автор: . Владелец: NOVARTIS AG. Дата публикации: 2013-02-28.

4-[(-methyl-4-oxido-1-piperazinyl)-methyl]-n-{4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]-amino]-phenyl}-benzamide,pharmaceutical compositions comprising it and use thereof for the preparation of medicaments for the treatment of a proliferative disorder

Номер патента: IL208399A0. Автор: . Владелец: NOVARTIS AG. Дата публикации: 2010-12-30.

4-[(4-methyl-4-oxido-1-piperazinyl)-methyl]-n-{4-methyl-3[[4-(3-pyridinyl)-2-pyrimidinyl]-amino]-phenyl}-benzamide, pharmaceutical compositions comprising it and use thereof for the preparation of medicaments for the treatment of a proliferative disorder

Номер патента: IL162979A. Автор: . Владелец: NOVARTIS AG. Дата публикации: 2010-12-30.

Carbamate / urea derived compounds, histamine h3 receptor inhibitors; preparation procedure; intermediate compound; pharmaceutical composition; pharmaceutical combination; and use in the treatment of narcolepsy.

Номер патента: CL2015000056A1. Автор: Yves Auberson,Dario Braga,Xiaoyang Wang,Mark Gary Bock,Stephanie Kay Dodd,Stefano Luca Giaffreda,Marco Curzi,Thomas J Troxler,Xuechun Zhang,Haiynag Jiang,Piort Karpinski,Tielin Wang. Владелец: NOVARTIS AG. Дата публикации: 2015-03-20.

Compounds derived from (4,4'-biphenylbis (1h-imidazol-4,2-diyl) -2,1-pyrrolidindiyl ((1s) -1 - ((2r, 6r) -2,4-dimethyltetrahydro-2h-pyran -4-yl) -2-oxo-2,1-ethanediyl))) dimethyl biscarbamate, vhc inhibitors; intermediary compounds; pharmaceutical composition; pharmaceutical combination; and use to treat a vhc infection.

Номер патента: CL2013002241A1. Автор: Makonen Belema,Gan Wang,Omar D Lopez,John A Bender,Jonh F Kadow. Владелец: Bristol Myers Squibb Co. Дата публикации: 2013-12-13.

Pyrrole-type compounds and uses thereof for treating viral infections

Номер патента: AU2021393753A1. Автор: Jacky Vonderscher,Benoit de Chassey,Frédéric MIEGE,Laurene Meyniel-Schicklin. Владелец: Enyo Pharma SA. Дата публикации: 2023-06-22.

Pyrrole-type compounds and uses thereof for treating viral infections

Номер патента: US20240002370A1. Автор: Jacky Vonderscher,Benoit de Chassey,Frédéric MIEGE,Laurene Meyniel-Schicklin. Владелец: Enyo Pharma SA. Дата публикации: 2024-01-04.

Pyrrole-type compounds and uses thereof for treating viral infections

Номер патента: AU2021393753A9. Автор: Jacky Vonderscher,Benoit de Chassey,Frédéric MIEGE,Laurene Meyniel-Schicklin. Владелец: Enyo Pharma SA. Дата публикации: 2024-10-10.

N-cyclopropyl-n-piperidinyl-amide derivatives, pharmaceutical compositions containing them and uses thereof

Номер патента: US20140031369A1. Автор: Frank Himmelsbach,Elke Langkopf,Nicole Harriott,Neil J. Ashweek. Владелец: Neurocrine Biosciences Inc. Дата публикации: 2014-01-30.

Pyrrole-type compounds and uses thereof for treating viral infections

Номер патента: WO2022117697A1. Автор: Jacky Vonderscher,Benoit de Chassey,Frédéric MIEGE,Laurene Meyniel-Schicklin. Владелец: Enyo Pharma. Дата публикации: 2022-06-09.

Pyrrole-type compounds and uses thereof for treating viral infections

Номер патента: EP4255901A1. Автор: Jacky Vonderscher,Benoit de Chassey,Frédéric MIEGE,Laurene Meyniel-Schicklin. Владелец: Enyo Pharma SA. Дата публикации: 2023-10-11.

Pyrrole-type compounds and uses thereof for treating viral infections

Номер патента: CA3199560A1. Автор: Jacky Vonderscher,Benoit de Chassey,Frédéric MIEGE,Laurene Meyniel-Schicklin. Владелец: Enyo Pharma SA. Дата публикации: 2022-06-09.

Ethyl-3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1- methyl-1h-benzimidazol-5-carbonyl)-pyridine-2-yl-amino]-propionic acid ethyl ester methane sulphonate in crystalline form ii, pharmaceutical composition comprising it and uses thereof for preparing pharmaceutical compositions which are suitable for the post-operative prophylaxis of deep vein thrombosis and the prevention of stroke and process for the preparation thereof

Номер патента: IL173885A. Автор: . Владелец: Boehringer Ingelheim Int. Дата публикации: 2015-04-30.

N-CYCLOPROPYL-N-PIPERIDINYL-AMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES THEREOF

Номер патента: US20140031369A1. Автор: Himmelsbach Frank,LANGKOPF Elke,ASHWEEK Neil J.,HARRIOTT Nicole. Владелец: . Дата публикации: 2014-01-30.

Fgfr4 inhibitor, pharmaceutical composition comprising it and use thereof

Номер патента: IL266659B. Автор: . Владелец: Guangdong Zhongsheng Pharmaceutical Co Ltd. Дата публикации: 2022-01-01.

1-aza-3-heteroaryl-azulene derivatives, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments

Номер патента: IL213019A. Автор: . Владелец: Ind Tech Res Inst. Дата публикации: 2014-07-31.

Paroxetine salts, process for their preparation, pharmaceutical compositions comprising these and uses thereof

Номер патента: DK199900554A. Автор: Andrew Simon Craig,Ward Neal,Jones Alan David,O'keeffe Deidre. Владелец: Smithkline Beecham Plc. Дата публикации: 2000-01-03.

Acyl-hydrazone and oxadiazole compounds, pharmaceutical compositions containing same and uses thereof

Номер патента: RU2664327C2. Автор: Рикарду Жозе НУНЭШ,Алессандра МАСКАРЕЛЛУ,Розенду Аугусту ЮНЭШ,Таиза Регина СТУМПФ,Паулу Сезар ЛЕАЛ,Жозе Андрэш ЮНЭШ,ДЕ СОЗА МЕЛУ Каролина ПЕРЕЙРА,Рафаэль Ренатину КАНЕВАРОЛУ,ШИАРАДИА Луиз ДОМЕНЕГИНИ,СИЛВЕЙРА Андре БОРТОЛИНИ,Анжелу Брунелли Альбертони ЛАРАНЖЕЙРА. Владелец: Сентро Инфантил Де Инвестигасоис Эматоложикас Др. Домингос А.Болдрини. Дата публикации: 2018-08-16.

Tricyclic compounds, pharmaceutical composition containing them and using them for treating immunological and oncological compounds

Номер патента: RU2545023C2. Автор: Лу ВАН,Кент Д. СТЮАРТ,Мария А. АРДЖИРИАДИ,Кристин Е. ФРЭНК,Грир А. УОЛЛЕЙС,Анна М. ЭРИКССОН,Кевин Р. ВОЛЛЕР,Дэвид Дж. КОЛДЕРВУД,Майкл ФРИДМАН,Эрик Р. ГОДКЕН,Натан С. ДЖОЗЕФСОН,Бицинь С. ЛИ,Майкл Дж. МОРЫТКО,Джеффри В. ВОСС,Нейл УИШАРТ,Брайан А. ФИАМЕНГО,Дон М. ДЖОРДЖ. Владелец: Эббви Инк.. Дата публикации: 2015-03-27.

Tricyclic compounds, pharmaceutical composition containing them and using them for treating immunological and oncological compounds

Номер патента: RU2545023C9. Автор: Лу ВАН,Кент Д. СТЮАРТ,Мария А. АРДЖИРИАДИ,Кристин Е. ФРЭНК,Грир А. УОЛЛЕЙС,Анна М. ЭРИКССОН,Кевин Р. ВОЛЛЕР,Дэвид Дж. КОЛДЕРВУД,Майкл ФРИДМАН,Эрик Р. ГОДКЕН,Натан С. ДЖОЗЕФСОН,Бицинь С. ЛИ,Майкл Дж. МОРЫТКО,Джеффри В. ВОСС,Нейл УИШАРТ,Брайан А. ФИАМЕНГО,Дон М. ДЖОРДЖ. Владелец: Эббви Инк.. Дата публикации: 2016-06-20.

Aromatic heterocyclic compound, pharmaceutical composition containing same, and use thereof

Номер патента: AU2022334383A1. Автор: Qing Lin,Jun Mo,Qiaojun HE,Qinjie WENG,Wenwen Nie,Binhui CHEN,Minjie GE. Владелец: Hang Zhou Yuhong Pharmatech Co Ltd. Дата публикации: 2024-02-22.

Substituted 8-sulphonyl-2,3,4,5-tetrahydro-1h-gamma-carbolines, ligands, pharmaceutical composition, synthesis method and use thereof

Номер патента: RU2404180C1. Автор: Александр Васильевич Иващенко,Николай Филиппович Савчук,Андрей Александрович Иващенко,Володимир Михайлович Кисиль,Олег Дмитриевич Митькин. Владелец: Алла Хем, Ллс. Дата публикации: 2010-11-20.

Aromatic heterocyclic compound, pharmaceutical composition containing same, and use thereof

Номер патента: EP4385993A1. Автор: Qing Lin,Jun Mo,Qiaojun HE,Qinjie WENG,Wenwen Nie,Binhui CHEN,Minjie GE. Владелец: Hang Zhou Yuhong Pharmatech Co Ltd. Дата публикации: 2024-06-19.

Pyrimido-isoquinolin-quinone derivative compounds, and pharmaceutically acceptable salts, isomers and tautomers thereof; pharmaceutical composition; preparation method; and use thereof in the treatment of diseases caused by bacteria and multidrug-resistant bacteria

Номер патента: US20190367505A1. Автор: Juan Andrés ANDRADES LAGOS,Javier Andrés CAMPANINI SALINAS,David Reinaldo Vásquez Velásquez. Владелец: Universidad De Chile. Дата публикации: 2019-12-05.

Cocrystal of piperacillin sodium and sulbactam sodium and preparation method thereof, as well as pharmaceutical compositions containing same and uses thereof

Номер патента: US09499565B2. Автор: Jing Li,Haiyong Wang. Владелец: BEIJING XINTIANYU TECHNOLOGY DEVELOPMENT CO LTD. Дата публикации: 2016-11-22.

Composition and methods of use of novel phenylalanine small organic compounds to directly modulate pcsk9 protein activity

Номер патента: EP3337497A1. Автор: Anjali Pandey,Thomas E. Barta,Simeon Bowers,Kyle D. MONROE,Michael M. MUEHLEMANN,Jonathan William Bourne. Владелец: Portola Pharmaceuticals LLC. Дата публикации: 2018-06-27.

Rapalogs, pharmaceutical compositions, preparation methods and uses thereof

Номер патента: CA2737355C. Автор: Jian Ding,Fajun Nan,Jianping Zuo,Min Gu,Yangming Zhang,Linghua Meng,Na Yang,Linqian Yu. Владелец: Shanghai Institute of Materia Medica of CAS. Дата публикации: 2015-01-13.

Heterocycle-benzoic acid derivatives, pharmaceutical compositions comprising them and uses thereof

Номер патента: IL178709A. Автор: . Владелец: Vantia Ltd. Дата публикации: 2016-09-29.

Tetrahydropyrrole compound, preparation method therefor, pharmaceutical composition containing same, and use thereof

Номер патента: CA3091555A1. Автор: Zhen Luo,Zhu DANG,Christine Jue CAI,Liugang WANG,Dan BAO. Владелец: Mediconns (shanghai) Biopharmaceutical Co Ltd. Дата публикации: 2019-07-04.

Receptor inhibitor, pharmaceutical composition comprising same, and use thereof

Номер патента: CA3094001C. Автор: Xiang Li,Hongjun Wang,Huai HUANG,Yanping Zhao,Yuanyuan JIANG,Yeming Wang,Liying Zhou,Ning SHAO,Fengping XIAO,Zhenguang ZOU,Fajie LI. Владелец: Beijing Tide Pharmaceutical Co Ltd. Дата публикации: 2024-01-23.

Receptor inhibitor, pharmaceutical composition comprising same, and use thereof

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ACIDS 2, 3, 4, 5-TETRAHYDRO. 1H. [1,4] -BENZODIAZEPINA-3-HYDROXAMICS AND PHARMACEUTICAL COMPOSITION CONTAINING THEM AND USE OF SUCH COMPOUNDS TO PREPARE A MEDICINAL PRODUCT.

Номер патента: AR017230A1. Автор: . Владелец: American Cyanamid Co. Дата публикации: 2001-08-22.

Antibiotic Compounds, Pharmaceutical Formulations Thereof And Methods And Uses Therefor

Номер патента: US20180312493A1. Автор: Tom Han Hsiao HSIEH,Alexander Laurence MANDEL,Robert Norman Young,Nag Sharwan Kumar,James Brian JAQUITH,Jason Samuel TAN,Fahimeh S. SHIDMOOSSAVEE,Edith Mary Dullaghan. Владелец: CENTRE FOR DRUG RESEARCH AND DEVELOPMENT. Дата публикации: 2018-11-01.

Quinoline and naphthyridine derivatives and salts thereof, processes for their preparation, pharmaceutical compositions containing them and use thereof as medicaments

Номер патента: IL128994A. Автор: . Владелец: Zeneca Pharma SA. Дата публикации: 2004-12-15.

Parp-1 degradation agent and use thereof

Номер патента: AU2022373697A1. Автор: Yao Li,Chen Zhang,Yan Yu,Lei Chen,Gang Hu,Haodong WANG,Hao Yao,Pingming Tang,Pangke Yan,Tiancheng HE,Pengxin GENG,Linyong FANG. Владелец: Xizang Haisco Pharmaceutical Co Ltd. Дата публикации: 2024-05-30.

COMPOUND, PHARMACEUTICAL COMPOSITION, COMBINATION, PRODUCT, AND USE OF A COMPOUND

Номер патента: BR112015026830B1. Автор: Patrick René Angibaud,Virginie Sophie Poncelet,Lieven Meerpoel,Isabelle Noelle Constance Pilatte,Olivier Alexis Georges Querolle. Владелец: ASTEX THERAPEUTICS LIMITED. Дата публикации: 2022-11-16.

Pyrrolo[2,3-d]pyrimidine-7 -yl-containing sulfamate compounds, pharmaceutical compositions comprising them and uses thereof

Номер патента: IL193141A. Автор: . Владелец: Millennium Pharm Inc. Дата публикации: 2017-10-31.

compound, pharmaceutical composition, method for treating disorders, use of compounds, drug, method for selecting inhibitors with small molecules of pcsk9 and small molecules

Номер патента: BR112012007241A2. Автор: Pingali Harikishore,Makadia Pankaj,R Jain Makul,V M Sairam Kalapatapu V. Владелец: Cadila Healthcare Ltd Soc Indiana. Дата публикации: 2019-09-24.

Bicyclosubstituted azopyrazolone derivatives salts, method for preparing and using them

Номер патента: RU2538977C2. Автор: Пэн Чо ТАН,Ицянь ЧЭНЬ,Хунбо ФЭЙ,Хэцзюнь ЛУ. Владелец: Шанхай Хэнжуй Фармасьютикал Со., Лтд.. Дата публикации: 2015-01-10.

Parp-1 degradation agent and use thereof

Номер патента: CA3235698A1. Автор: Yao Li,Chen Zhang,Yan Yu,Lei Chen,Gang Hu,Haodong WANG,Hao Yao,Pingming Tang,Pangke Yan,Tiancheng HE,Pengxin GENG,Linyong FANG. Владелец: Xizang Haisco Pharmaceutical Co Ltd. Дата публикации: 2023-04-27.

11-piperazinyl-dibenzo[b,f][1,4]oxazepine compounds, process for the preparation thereof, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments

Номер патента: IL200250A. Автор: . Владелец: Andaman Therapeutics Inc. Дата публикации: 2014-12-31.

Polymorph of 4-[2-[4-[1-(2-ethoxyethyl)-1h-benzimidazole-2-yl]-1-piperidinyl]ethyl]-alpha, alpha-dimethyl-benzeneacetic acid, process for producing it, pharmaceutical compositions containing it and use thereof

Номер патента: HU0500241A2. Автор: Aurelio Orjales Venero,Ramon Mosquera Pestana,Maria Luisa Lucero De Pablo,Maravillas Bordell Martín,Gonzalo Canal Mori,Haydée Blanco Fuente,Victor Rubio Royo. Владелец: Faes Farma, S.A.. Дата публикации: 2005-06-28.

Hydroxymethyl pyrrolidines, pharmaceutical compositions comprising same and use thereof for preparation of medicaments

Номер патента: IL208215A. Автор: . Владелец: Merck Sharp & Dohme. Дата публикации: 2014-04-30.

Cyclohexylamine derivatives having beta2 adrenergic and m3 muscarinic modulating activities, pharmaceutical compositions comprising them and use thereof in the manufacture of medicaments

Номер патента: IL222538A. Автор: . Владелец: Almirall SA. Дата публикации: 2015-11-30.

Pyridine derivative inhibiting RAF kinase and vascular endothelial growth factor receptor, method for preparing same, pharmaceutical composition containing same, and use thereof

Номер патента: US10844062B2. Автор: Jong Min Kim,Sung Pyo Hong,Sung Hye Kim,Hee Jong Shin,Min Hyo Ki,Soon Kil Ahn,Hyun Tae Kim,Hyoung Min Cho,Jae Woong LEE,Jeong Ho Joo,Ho Seok Kwon,Sung Hyun Kang,Eui Hwan Cho,Keun Kuk Lee,Yong Bin Park. Владелец: BAMICHEM Co Ltd. Дата публикации: 2020-11-24.

Fused ring compound, pharmaceutical composition containing same, and use of fused ring compound

Номер патента: AU2023254280A1. Автор: Lin Chen,Yingfu Li,Guoqing ZHUO,Zhiquan SONG,Junfeng REN,Guanfeng LIU,Xiancai WU,Chenguang Yuan,Shai LI,Shoubing YI. Владелец: Shenzhen Hyperway Pharmaceuticals Co Ltd. Дата публикации: 2024-09-12.

Thienopyridazine compounds, preparing them, pharmaceutical compositions containing them, and using them

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Novel octahydropyridoquinazoline derivative, pharmaceutical composition containing same, and uses for said deriavative and composition

Номер патента: US20150315183A1. Автор: Kiyoshi Kasai,Toshihiro Nishimura,Yasunori Ueno,Masako Yoshida. Владелец: Kissei Pharmaceutical Co Ltd. Дата публикации: 2015-11-05.

C-aryl glycosid derivatives, pharmaceutical composition, preparation process and uses thereof

Номер патента: US09914724B2. Автор: Pei Wang,Heping Yang,Daxin Gao. Владелец: Shanghai de Novo Pharmatech Co Ltd. Дата публикации: 2018-03-13.

Aniline derivative, pharmaceutical composition containing same, and use thereof

Номер патента: US09718771B2. Автор: Tetsuya Nakamura,Hitoshi Inoue,Kohsuke Ohno,Yusuke Ohsawa. Владелец: Kissei Pharmaceutical Co Ltd. Дата публикации: 2017-08-01.

Tetrahydroisoquinoline compound, preparation method therefor, pharmaceutical composition containing same, and use thereof

Номер патента: CA3090598C. Автор: Xu Han,HONG Liu,Heng Li,Wei Tang,Fenghua Zhu,Hualiang Jiang,Kaixian Chen,Yechun Xu,Tiantian CHEN,Guangyu DONG,Chunlan Feng,Xianglei ZHANG,Zhanni GU,Wuyan CHEN. Владелец: Shanghai Institute of Materia Medica of CAS. Дата публикации: 2024-01-09.

Bis[thio-hydrazide amide] derivatives, pharmaceutical compositions comprising them and uses thereof for the manufacture of medicaments to enhance the anti-cancer activity of paclitaxel or of a paclitaxel analog

Номер патента: IL159773A. Автор: . Владелец: Synta Pharmaceuticals Corp. Дата публикации: 2011-11-30.

Substituted pyrazine compound, pharmaceutical composition comprising same, and use thereof

Номер патента: EP4169913A4. Автор: Yu Yang,Lei Yi,Jingyi Wang,Shoujun Chen,Qian Liu,Qiang Tian,Hongmei SONG,Huiping Chen,Liqiang Song,Taijin Wang,Yong Ge. Владелец: Sichuan Kelun Biotech Biopharmaceutical Co Ltd. Дата публикации: 2024-10-30.

Substituted pyrazine compound, pharmaceutical composition comprising same, and use thereof

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SUBSTITUTED BICYCLE DERIVATIVES OF CARBOXAMIDA AND UREA, PHARMACEUTICAL COMPOSITIONS CONTAINING THEMSELVES AND USE OF THEM IN THE TREATMENT OF PAIN, ALZHEIMER AND OTHER AFFECTIONS OF THE CENTRAL NERVOUS SYSTEM, AS WELL AS ALSO DISEASES AND DISEASES

Номер патента: AR083816A1. Автор: Frank Robert Dr,Christoph Thomas Dr,Frormann Sven Dr. Владелец: GRUENENTHAL GmbH. Дата публикации: 2013-03-27.

PIRAZOL DERIVATIVE COMPOUNDS, 5-HT2A RECEIVER MODULATORS; PHARMACEUTICAL COMPOSITION; PREPARATION PROCEDURE; AND USE OF THE COMPOUND FOR THE TREATMENT OF CORONARY ARTERIOPATIA, INFARTO MIOCARDICO, ANGINA, SOUND DISORDER, ASTHMA, REDUCE

Номер патента: CL2007002859A1. Автор: Yifeng Cherrier Martin C Xiong. Владелец: Arena Pharm Inc. Дата публикации: 2008-06-06.

Thiohydantoins, process for their preparation, pharmaceutical compositions containing them and use thereof for preparation of pharmaceutical compositions

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Quinazoline derivatives process for their preparation their use and pharmaceutical compositions containing them

Номер патента: IL107678A. Автор: . Владелец: Zeneca Ltd. Дата публикации: 1999-03-12.

Certain substituted caprolactams, pharmaceutical compositions containing them and their use in treating tumors

Номер патента: CA2347773C. Автор: Kenneth Walter Bair,Frederick Ray Kinder Jr.,Richard William Versace,Christopher Turchik Jagoe,Sompong Wattanasin. Владелец: NOVARTIS AG. Дата публикации: 2009-03-10.

Azabicycloalkanes, pharmaceutical composition containing them, and use thereof as ccr5 modulators

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Substituted imidazoles and thiazoles, pharmaceutical composition containing them and use thereof

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Substituted indolinones, method for their production, pharmaceutical composition containing them and use thereof

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Indole derivatives, pharmaceutical compositions comprising them and use thereof for the manufacture of a medicament for the treatment of diseases associated with over activity of osteoclasts

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DERIVATIVES OF REPLACED PYRIMIDINS, ITS PREPARATION PROCEDURE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THE USE OF THEM FOR THE PREPARATION OF MEDICINES

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PIRIDONS REPLACED AS POLI (ADP-RIBOSA) -POLIMERASA (PARP) INHIBITORS, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THE USE OF THE SAME FOR THE TREATMENT OF CARDIOVASCULAR DISORDERS AND THE CENTRAL NERVOUS SYSTEM.

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Compounds that are CB2 Receptor Agonists, Pharmaceutical Compositions Containing Them, and Therapeutic Use of the Compounds

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Boronated metal-phthalocyanines, process for their preparation, pharmaceutical compositions comprising them and use thereof

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Composition and methods of use of tetrahydroisoquinoline small molecules to bind and modulate PCSK9 protein activity

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compounds, processes for their manufacture, pharmaceutical compositions comprising them and uses thereof

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Pharmaceutical compositions containing ipidacrine and use thereof to treat potency disorders and other sexual activity disorders

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Receptor inhibitor, pharmaceutical composition comprising same, and use thereof

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Delta and epsilon crystal forms of imatinib mesylate, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for therapy

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Cocrystal of piperacillin sodium and sulbactam sodium and preparation method thereof, as well as pharmaceutical compositions containing same and uses thereof

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Tetrahydropyrrole compound, preparation method therefor, pharmaceutical composition containing same, and use thereof

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8-azoniabicyclo[3,2,1]octane derivatives, pharmaceutical compositions comprising them and use thereof in the manufacture of medicamentes for the treatment of a muscarinic acetylcholine receptor mediated disease

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Pharmaceutical Compositions Containing Ipidacrine and Use Thereof to Treat Potency Disorders and Other Sexual Activity Disorders

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Selective allosteric inhibitors of epidermal growth factor receptor mutants, pharmaceutical compositions comprising them and use thereof

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Oxapenem - 3 - carboxylic acid, pharmaceutical compositions containing it and uses thereof

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Crystalline forms of celecoxib, pharmaceutical composition comprising the same, the use of the same for the preparation of drug and the method for the preparation of the same.

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CONTRACEPTIVE PEPTIDES DERIVED FROM THE VENOM OF THE SPIDER Latrodectus mirabilis, NUCLEOTIDE SEQUENCES TO TRANSFORM A MICROORGANISM TO PRODUCE SAID PEPTIDES; METHODS TO OBTAIN THE PEPTIDES; PHARMACEUTICAL COMPOSITIONS CONTAINING THEREOF AND USE THEREOF

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Conjugate of a single domain antibody, a saponin and an effector molecule, pharmaceutical composition comprising the same, therapeutic use of said pharmaceutical composition

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Contraceptive peptides derived from the venom of the spider Latrodectus mirabilis, nucleotide sequences to transform a microorganism to produce said peptides; methods to obtain the peptides; pharmaceutical compositions containing thereof and use thereof

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Pharmaceutical composition of pembrolizumab and use thereof

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Compositions and methods for use of recombinant t cell receptors against claudin 6

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Compositions and methods of use of alpha-1 antitrypsin fusion polypeptides

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Compositions and methods of use of targeting peptides against placenta and adipose tissues

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Compositions and methods of use of oncolytic virus like vesicles

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Anti-vegf-anti-pd-l1 bispecific antibody, pharmaceutical composition of same, and uses thereof

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Compositions and methods for use of bioactive agents derived from sulfated and sulfonated amino acids

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Compositions and methods for use of recombinant t cell receptors for direct recognition of tumor antigen

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Compositions and methods for use of recombinant t cell receptors against claudin 6

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Compositions and method of use of mutant ace2 decoy variants

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Novel chroman-2-one derivatives and use thereof as monoamine neuromediator reuptake inhibitors

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Certain substituted caprolactam carbonates and ethers, pharmaceutical compositions containing them and their use in treating tumors

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Benzenesulfonanilide derived compounds; pharmaceutical composition comprising them; and use in the treatment of diseases of the central nervous system, cognitive dysfunctions, schizophrenia, addictive diseases, Alzheimer's disease or obesity.

Номер патента: CL2008003232A1. Автор: Turner,ZHANG,Unger,Lange,Wicke,Braje,Haupt,Drescher,Mezler,Wernet W,Mayrer,Jongen-Relo,Bespalov. Владелец: Abbott Gmbh & Co Kg. Дата публикации: 2009-11-27.

Cyclic amine compounds, pharmaceutical compositions containing them and the use of the compounds for the manufacture of a drug especially senile dementia

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Novel quinoline derivatives and uses thereof

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Programmed cell necrosis inhibitor, preparation method therefor, and use thereof

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Programmed cell necrosis inhibitor, preparation method therefor, and use thereof

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SUBSTITUTED (PYRIDINYLAMINO)-BENZISOXAZOLES AND BENZO[b]THIOPHENES, PROCESS OF THEIR PREPARATION, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND USE OF THESE COMPOUNDS

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RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF

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4-OXO-6-AMINOMETHYL-QUINAZOLINE DERIVATIVES, PROCEDURES FOR THE PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION INCLUDING THEM AND USING THEM FOR THE TREATMENT OF TUMORS

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Indoles active as modulators of nicotinic acetylcholin receptor subtype alpha-7, pharmaceutical compositions comprising them and use thereof in the manufacture of medicaments for the treatment of psychotic disorders

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Compounds derived from spirocyclic heterocycles substituted by substituted quinazoline-linked ethers; pharmaceutical composition; pharmaceutical combination; and use in the treatment of lung and respiratory diseases, autoimmune disease, allergic diseases and cancer, among others.

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N - (2 - arylethyl) benzylamines, pharmaceutical compositions comprising them and uses thereof for the manufacture of a medicament for treating disorders associated with the 5-ht6 receptor

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Substituted isoquinoline derived compounds; nk3 antagonist; pharmaceutical composition comprising it; and use in the treatment of diseases such as psychosis, schizophrenia, Alzheimer's, Parkinson's, among others.

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Derivatives of N-(arylsulfonyl)-beta-amino acids comprising a aminomethyl group, preparation method thereof, pharmaceutical compositions containing same and the use of them

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GLUCOKINASE ACTIVATING COMPOUNDS CONTAINING REPLACED HYDANTOIN, A PROCEDURE FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS, PROCEDURES FOR THEIR PREPARATION, USE OF THE SAME FOR THE PREPARATION OF MEDICINES

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The bis-aryl compound, the pharmaceutical composition containing it and the use of the compound for the preparation of a medicine acting as a potassium channel blocker

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Novel imidazopyrimidine compound and uses thereof

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Novel hydroxy-ester derivatives, a method for production thereof and pharmaceutical compositions containing them

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HOMOGENEOUS CRYSTALLINE POLYMORPHES OF N - (3 - ETHYLFENYL) CHLORHYDRATE - 6, 7 - BIS (2 - METOXIETOXI) - 4 QUINAZOLINAMINE; PHARMACEUTICAL COMPOSITIONS FORMULATED WITH SUCH POLYMORPHES; USE OF THE SAME IN THE PREPARATION OF SUCH COMPOSITIONS; PROCESS FOR THE PREPARATION OF POLYMORPH B

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Antimicrobial compounds, pharmaceutical compositions comprising them and uses thereof

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Bivalent compounds, conjugates and uses thereof

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Bivalent compounds, conjugates and uses thereof

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Aniline derivative, pharmaceutical composition containing same, and use thereof

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Cannabis compositions and methods

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Cannabis compositions and methods

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Cannabis compositions and methods

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Amide derivative and preparation method therefore and use thereof in medicine

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Amide derivative and preparation method therefore and use thereof in medicine

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Thienopyrimidine compound, preparation method thereof, pharmaceutical composition and application thereof

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Compositions and methods for cancer treatment

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Bicyclic urea kinase inhibitors and uses thereof

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NOVEL OCTAHYDROPYRIDOQUINAZOLINE DERIVATIVE, PHARMACEUTICAL COMPOSITION CONTAINING SAME, AND USES FOR SAID DERIAVATIVE AND COMPOSITION

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Thienopyrimidine derivatives, process for their preparation, pharmaceutical compositions containing them and their use in the treatment of conditions involving a defect in apoptosis

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Quinazoline derivatives, pharmaceutical compositions containing them and use thereof in the manufacture of medicaments useful for treating or preventing flaviviridae infection

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C- ARYL GLYCOSID DERIVATIVES, PHARMACEUTICAL COMPOSITION, PREPARATION PROCESS AND USES THEREOF

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Novel aniline derivative, pharmaceutical composition containing same, and use thereof

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Crystalline forms of trametinib and solvate thereof, preparation method therefor, pharmaceutical composition comprising same and use thereof

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Sphaelactone derivatives, their pharmaceutical compositions, preparation methods and uses

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AMINO ALCOHOL DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USE THEREOF

Номер патента: DE602004014727D1. Автор: Junichi Kobayashi,Tetsuya Nakamura,Takehiro Ishikawa,Tetsuro Tamai,Hideyuki Muranaka,Tatsuhiro Kondo,Yuichiro Kai,Tomonaga Ozawa,Satoshi Akahane,Ritsu Suzuki. Владелец: Kissei Pharmaceutical Co Ltd. Дата публикации: 2008-08-14.

Novel thyroid hormone receptor ligands, pharmaceutical compositions containing them, and uses thereof

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Dihydro-oxazolobenzodiazepinone derivatives, processes for their perparation , pharmaceutical compositions comprising them and uses thereof

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aziridinyl-eptiolone analog conjugate, pharmaceutical compositions comprising them and uses thereof

Номер патента: BRPI0712165A2. Автор: D. Vite Gregory,Inc Endocyte,Y. Lee Francis,Paul Leamon Christopher,Radoslavov Vlahov Iontcho. Владелец: BRISTOL-MYERS SQUIBB COMPANY. Дата публикации: 2012-02-14.

Compounds derived from indolizine; preparation procedure; pharmaceutical compositions containing them and use in the treatment of cancer.

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P2X3 and/or P2X2/3 receptor antagonists, pharmaceutical compositions containing them, and uses thereof

Номер патента: CN113924293A. Автор: 刘亚男,王红军,赵焰平,周丽莹,王业明. Владелец: Beijing Tide Pharmaceutical Co Ltd. Дата публикации: 2022-01-11.

Quinoline derivative, and pharmaceutical composition, preparation method and use thereof

Номер патента: WO2017049711A1. Автор: 张茹玲. Владелец: 上海海聚生物科技有限公司. Дата публикации: 2017-03-30.

Substituted pyrrolopyrimidine CDK inhibitor, pharmaceutical composition containing same and use thereof

Номер патента: TW201734018A. Автор: BO LIU,Hong Luo,Mei Liu,Yong Peng,Kun-Cheng Chen,shu-long Wang,xi-jie Liu,Yuan-Dong Hu,yong-xin Han,shan-chun Wang,hong-jiang Xu. Владелец: Lianyungang Runzhong Pharmaceutical Co Ltd. Дата публикации: 2017-10-01.

3- (1-chlorophenyl) -7-oxo-6- [4- (2-oxo-1 (2h) pyridinyl) phenyl] -4,5,6,7-tetrahydro-1h-pyrazolo [3,4-c ] pyridine-3-carboxamide and 3- (1-hydroxy-1-methyl-ethyl) -1- (a-methoxy-phenyl) -6- [4- (2-oxo-2h-pyridin-1-yl) - phenyl] -1,4,5,6-tetrahydro-pyrazolo [3,4-c] pyridin-7-one; pharmaceutical composition; Pharmaceutical combination and use in the treatment of a thromboembolic disorder

Номер патента: CL2008002717A1. Автор: HAN Wei,Li Yun-Long,J Pinto Donald,J Orwat Michael,L Quan Mimi,X Qiao Jennifer,y s lam Patrick,Stephanie. Владелец: Bristol Myers Squibb Pharma Company. Дата публикации: 2009-01-09.

Sulfonamide derivatives, process for their preparation, pharmaceutical compositions comprising them and use thereof for the manufacture of a medicament having beta2 agonist activity

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DERIVATIVES OF INHIBITING HETEROCICLIC AZAINDOLS OF JAK-3 QUINASAS, AURORA A AND ROCK, PHARMACEUTICAL COMPOSITIONS CONTAINING THEMSELVES AND THE USE OF THE SAME IN THE TREATMENT OF CENTRAL NERVOUS SYSTEMS AND IMMUNIC AND ALLERGIC DISORDERS.

Номер патента: AR079749A2. Автор: Jeremy Green,Hayley Binch,Alex Aronov,Luc Farmer,Michael Mortimore,Daniel Robinson,Dean Boyall,Simon Everitt,David J Lauffer,Randy S Bethiel,Jean-Damien Charrier,Francesco G Salituro,Francoise Pierard,John J Court,Jon H Come,Edmund M Harrington,Damien Fraysee. Владелец: Vertex Pharma. Дата публикации: 2012-02-15.

Compositions and methods for use of cannabinoids for neuroprotection

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Compositions and methods for use of cannabinoids for neuroprotection

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Compositions and methods for use of cannabinoids for neuroprotection

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New (acyloxymethyl)acrylamide esters, pharmaceutical composition containing them, and using them as thioredoxin - thioredoxin-reductase system inhibitors

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14$g(b)-H-STEROLS, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM AND USE OF THESE DERIVATIVES FOR THE PREPARATION OF MEIOSIS REGULATING MEDICAMENTS

Номер патента: EP1177205A1. Автор: HENRY Laurent,Christa Hegele-Hartung,Thorsten Blume,Joachim Kuhnke,Peter Esperling,Monika Lessl. Владелец: Schering AG. Дата публикации: 2002-02-06.

Acyloxyalkyl carbamate prodrugs of tranexamic acid, pharmaceutical compositions comprising them and uses thereof

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Butenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them and use for the treatment of dyslipidaemia, atherosclerosis and diabetes

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Antibody-tlr agonist conjugates, methods and uses thereof

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Derivatives of imidazole as inhibitors of prenyl transferase, pharmaceutical composition and methods for treatment based on thereof

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Derivatives of purinic and pyrimidinic antiviral agents and use thereof as potent anticancer agents

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DHA esters and use thereof in treatment and prevention of cardiovascular disease

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Compounds derived from pyrido [4,3-b] -indole fused, cathepsin k inhibitors; pharmaceutical composition; preparation procedure; and use of the compound in the treatment of diseases such as osteoporosis, osteoarthritis, rheumatoid arthritis and bone metastatic diseases, among others.

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SUBSTITUTED PYRROLOPYRIMIDINE CDK INHIBITOR, PHARMACEUTICAL COMPOSITION CONTAINING SAME AND USE THEREOF

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PYRIMIDO-ISOQUINOLIN-QUINONE DERIVATIVE COMPOUNDS, AND PHARMACEUTICALLY ACCEPTABLE SALTS, ISOMERS AND TAUTOMERS THEREOF; PHARMACEUTICAL COMPOSITION; PREPARATION METHOD; AND USE THEREOF IN THE TREATMENT OF DISEASES CAUSED BY BACTERIA AND MULTIDRUG-RESISTANT BACTERIA

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Novel benzoxazine benzimidazol derivatives, pharmaceutical composition comprising same, and use thereof

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Aminoalcohol derivatives, pharmaceutical compositions containing them, and uses thereof

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Compounds derived from 2-amino-chromen-4-one; pharmaceutical composition comprising it; and use in the treatment of a disease that is alleviated by inhibition of DNA-dependent protein kinase (DNA-pk), such as cancer.

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Phenyl-piperazine derivatives as serotonin reuptake inhibitors, pharmaceutical compositions containing them and use thereof

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Pharmaceutical compositions and methods of use of highly lipophilic sulfhydryl compounds

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? Dihydrobenzofuranyl-piperidinyl, aza-dihydrobenzofuranylpiperidinyl and diaza-dihydrobenzofuranyl-piperidinyl derivatives, pharmaceutical compositions containing them and uses thereof?

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2-Cyano-3-hydroxy-propenamide, a process for its preparation, pharmaceutical compositions containing it and uses thereof as medicaments

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Compounds derived from n - [(2s) -5- (oxy-substituted) -2,3-dihydro-1h-inden-2-yl] -2-propanesulfonamide; pharmaceutical composition comprising it; and use to treat or prevent a disease caused by a reduction or imbalance of glutamate receptor function, such as schizophrenia.

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Pharmaceutical compositions and methods of use of highly lipophilic sulfhydryl compounds

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Benzonaphthyridines, pharmaceutical composition containing them and use

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Alkoxy alkyl carbamates from imidazo(1,2-a)pyridines, their preparation process and pharmaceutical composition containing them and use

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Compounds derived from cyclobutanoamino acids, modulators of s1p receptors; pharmaceutical composition; preparation procedure; and use in the treatment of arthritis, autoimmune diseases, type I diabetes, chronic obstructive pulmonary disease, among others.

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Quinolinyl derivatives, method for preparing same, pharmaceutic compositions containing same, and use thereof as hypoglycemiant and hypolipemiant agents

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PIRROLOPIRIDINE COMPOUNDS REPLACED INHIBITORS OF KINASES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES IN THE TREATMENT OF CANCER

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3,7-dihydropurine-2,6-dione derivatives, processes for their preparation, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments

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Novel farnesyl transferase inhibitors, preparation, pharmaceutical compositions containing them and use for preparing medicines

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Derivatives of 4-piperazin-1-yl-4-benzo[b]thiophene, process for their preparation, pharmaceutical compositions comprising same and use thereof in the manufacture of medicaments for the treatment of central nervous system disorders

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Fused acridine derivative and pharmaceutical composition, preparation method and use thereof

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Substituted morpholine and thiomorpholine derivatives, pharmaceutical composition based thereon and use thereof for the preparation of medicament for the treatment of a disorder or disease of the central nervous system

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N-substituted 2-cyanopyrrolidines, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for treating conditions mediated by dpp-iv inhibition

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Compounds with nootropic action, their preparation, pharmaceutical compositions containing them, and use thereof

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3-Amino-1,2-propane diols, process for their preparation, pharmaceutical compositions containing them and use thereof.

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Crystal modification of 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole- 4-carboxamide, pharmaceutical compositions containing it and use thereof

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DERIVATIVES OF PIRAZOL [4,3-D] TIAZOL, METHOD OF PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND USES AS ANTI-BANGEOUS AGENTS

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Aminoalcohol derivatives, pharmaceutical compositions containing them, and uses thereof

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Monoester compound, pharmaceutical composition it containing, and use of this compound

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compound of pyridine substituted with heterocyclic ring and phosphonoxymethyl group or a salt thereof, pharmaceutical composition comprising them and use of them to treat a fungal disease

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Il-13 binding construct comprising at least one antibody single domain (dab) grafted onto a monoclonal antibody (mabdab); polynucleotide and host cell; procedure to prepare the construction; pharmaceutical composition comprising it and used to treat cancer or inflammatory diseases.

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Substituted benzoyl-guanidine derivatives, process for producing them, pharmaceutical compositions containing them and the use of the compds.

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Substituted benzoyl-guanidine derivatives, process for producing them, pharmaceutical compositions containing them and the use of the compds.

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Kokumi flavour compounds and use

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Kokumi flavour compounds and use

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Pharmaceutical composition containing bromocryptine and use of same for acquired immunodeficiency states

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Combinations comprising a signal transduction inhibitor and an epothilone derivative, pharmaceutical compositions comprising them and use thereof in the preparation of medicaments for delay of progression or treatment of proliferative diseases

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Compositions and methods of use of ritonavir for treating hcv

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Compositions and methods for use of eflornithine and derivatives and analogs thereof to treat cancers, including gliomas

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Stabilized biopolymer composition, their manufacture and use

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Methods for reprogramming cells and uses thereof

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Pharmaceutical composition containing lysozyme and use thereof

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Pharmaceutical composition comprising plasminogen and uses thereof

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Sirna targeting angiotensinogen and pharmaceutical use of sirna

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Sirna targeting angiotensinogen and pharmaceutical use of sirna

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Methods for reprogramming cells and uses thereof

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Whey protein hydrolyzate, process for its preparation, pharmaceutical composition, food product and use.

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Pharmaceutical composition containing lysozyme and use thereof

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Use of a silica xerogel for the preparation of a slow release delivery device, the delivery device, pharmaceutical composition comprising it, and the use of silica xerogel for the preparation of a delivery device for administration of a biologically active agent

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Use of microrna mimics to inhibit or treat liver disease

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Compositions and methods of use of phorbol esters

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Combination of palmitoylethanolamide and equisetum, food, nutraceutical and/or pharmaceutical compositions containing it, and use thereof in the prevention and treatment of osteoporosis

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