11-02-2016 дата публикации
Номер: US20160038496A1
Принадлежит:
Described herein is the Bruton's tyrosine kinase (Btk) inhibitor 1-((R)-3-(4-amino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidin-1-yl)prop-2-en-1-one, including novel pharmaceutical formulations thereof. Also disclosed are pharmaceutical compositions that include the Btk inhibitor, as well as methods of using the Btk inhibitor, alone or in combination with other therapeutic agents, for the treatment of autoimmune diseases or conditions, heteroimmune diseases or conditions, cancer, including lymphoma, and inflammatory diseases or conditions. 2. The pharmaceutical composition of claim 1 , wherein the solid dispersed ibrutinib is a spray-dried ibrutinib composition.3. The pharmaceutical composition of claim 2 , wherein the spray-dried ibrutinib composition comprises ibrutinib dispersed into one or more solubility enhancers.4. The pharmaceutical composition of claim 3 , wherein the solubility enhancer is a polymer matrix; and the polymer matrix comprises one or more polymers.5. The pharmaceutical composition of claim 4 , wherein the spray-dried ibrutinib composition comprises 1-90% w/w ibrutinib dispersed into the polymer matrix.6. The pharmaceutical composition claim 4 , wherein the polymer in the polymer matrix is a linear polymer claim 4 , a cross-linked polymer claim 4 , a co-polymer claim 4 , a graft polymer; or any combination thereof.7. The pharmaceutical composition of claim 4 , wherein the polymer has a molecular weight in a range of about 2 claim 4 ,000 to about 500 claim 4 ,000 daltons claim 4 , about 100 claim 4 ,000 to about 200 claim 4 ,000 daltons claim 4 , about 200 claim 4 ,000 to about 300 claim 4 ,000 daltons claim 4 , or about 400 claim 4 ,000 to about 500 claim 4 ,000 daltons.8. A solid dispersion formulation comprising a solid dispersion pharmaceutical composition according to claim 1 , and a pharmaceutically acceptable carrier.9. The solid dispersion formulation of claim 8 , wherein the solid dispersion formulation is in a form of ...
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