Malaria immunogen and vaccine
30-06-2003 дата публикации
Номер:
AP2003002751A0
Автор: BIRKETT ASHLEY J, BIRKETT ASHLEY J.
Принадлежит: Apovia Inc
Контакты:
Номер заявки: 27-00-200351
Дата заявки: 16-08-2001
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid protein (IIBc) is disclosed that contains an immunogen for inducing the production of antibodies to malarial proteins. An immunogenic malarial epitope is expressed between residues 78 and 79 of the IIBc immunogenic loop sequence the chimer preferably contains a malaria-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.