Budesonide aerosol preparation with hydrofluoroalkane used as propellant
The invention discloses a budesonide aerosol. The aerosol comprises budesonide, granular drugs of physiologically acceptable salt and solvate of the budesonide and a hydrofluoroalkane propellant; optionally, the aerosol does not contain a surfactant basically; and optionally, the aerosol does not contain a co-solvent with the polarity higher than that of the propellant basically. Experimental results indicate that the aerosol is a medical aerosol good in stability. 1. Budesonide aerosol, which comprises: Budesonide and its physiologically acceptable salt of the micronised and solvolyte particulate drug; Propellant hydrofluoroalkanes; The basic and higher than the propellant does not contain the polarity of the polarity of the co-solvent, or containing surface-active agent; Wherein the micronized particulate medicament aerosol of the 0.01-5% W/W; 90% W/W of the particulate medicament is less than the diameter of the 5 m, 50% W/W of the particulate medicament is less than the diameter of the 3 m. 2. If the right of the aerosol, wherein the micronized particulate medicament aerosol of the 0.01-3% w/w. 3. Aerosol according to Claim 1, wherein by the airstream grinding particulate medicament. 4. Aerosol according to Claim 1, wherein the propellant is 1, 1, 1, 2-tetrafluoroethane or 1, 1, 1, 2, 3, 3, 3- seven fluorine are positive propane or mixtures thereof. 5. Budesonide aerosol, is prepared from the following components: The aerosol of the 0.01-5% W/W of the budesonide and its physiologically acceptable salt of the micronised and solvolyte particulate drug; Propellant hydrofluoroalkanes and; Wherein 90% W/W of the particulate medicament is less than the diameter of the 5 m, 50% W/W of the particulate medicament is less than the diameter of the 3 m. 6. Budesonide aerosol, is prepared from the following components: The aerosol of the 0.01-5% W/W of the budesonide and its physiologically acceptable salt of the micronised and solvolyte particulate drug; Propellant hydrofluoroalkanes; Preparation of not more than and 1% W/W of a surfactant; Wherein 90% W/W of the particulate medicament is less than the diameter of the 5 m, 50% W/W of the particulate medicament is less than the diameter of the 3 m. 7. Budesonide aerosol, is prepared from the following components: The aerosol of the 0.01-5% W/W of the budesonide and its physiologically acceptable salt of the micronised and solvolyte particulate drug; Propellant hydrofluoroalkanes; Is not greater than and propellant 0.5% W/W the polarity of the polarity of the co-solvent is higher than the propellant; Wherein 90% W/W of the particulate medicament is less than the diameter of the 5 m, 50% W/W of the particulate medicament is less than the diameter of the 3 m. 8. To 7 a according to Claim 5 of the aerosol, wherein the aerosol of accounts for 0.01-3% W/W of the budesonide and its physiologically acceptable salt of the micronised and solvolyte particulate drug. 9. Comprising -8 a in the aerosol can of aerosol according to Claim 1, which comprises a can bear the aerosol vapor pressure of the container, the container is provided with a metering valve nozzle, the nozzle has a diameter of 0.2-0.6 mm. 10. The aerosol canister according to Claim 9, which comprises a can bear the aerosol vapor pressure of the container, the container is provided with a metering valve nozzle, the nozzle has a diameter of 0.3-0.5 mm.