PHARMACEUTICAL COMPOSITION FOR INCREASING EXPRESSION OF ANTI-APOPTOTIC ENZYME AND FOR INHIBITING EXPRESSION OF APOPTOSIS-INDUCING ENZYME WITH RESPECT TO TEMPERATURE CHANGE, COMPRISING ACTIVE GINSENG AND REFINED EXTRACT OF ANGELICA GIGAS NAKAI AS ACTIVE INGREDIENT
The present invention refers to active Ginseng and per the truth consequent appearance in court sacrificial offering according to the temperature changes that contain as the active ingredient an apoptosis induction expression inhibition and harbor dues gun extinction enzyme in relates to a pharmaceutical composition for expression amount, and Ginseng type more safe and speedy method than the composition mixed per the truth consequent appearance in court sacrificial offering temperature change according to stress-induced cell apoptosis induction expression of enzymes reduce the, Ginseng active increasing the expression harbor dues gun extinction enzymeper the truth consequent appearance in court sacrificial offering and according to the temperature changes that contain as the active ingredient an apoptosis induction expression inhibition and harbor dues gun extinction enzyme relates to a pharmaceutical composition for expression amount is. Global warming (Global warming) by globe of each annual mean temperature which such that the gaseous support medium rises continuously such that, the sudden rising temperature is on the increase mortality population old there is a trend.. To prevent such global warming rated various mixed with the previous although the an alternative solution connected with the temperature rises, to be subsequently of wet liquid to flow down it is shown. Globe of each temperature continuously such that as the temperature a rotation preventing device which are weak in physical strength since the old cell apoptosis is derived is mounted on the upper plate of the mortality old. Thus in order to reduce the mortality old temperature stress-induced cell apoptosis for reducing. it is important to. General as a variety of pharmacologically active demonstrated to have known representative during the active to Ginseng current (Active ginseng, Actigin) and a per the truth consequent appearance in court sacrificial offering (Angelica gigas Nakai Extract, Agnex) is connected to the semiconductor layer.. Ginseng a class of novel Ginseng, wild, sheep harboring a wood, coal and oil, Mn11-mn17 a wood, coal and oil, firearm a wood, coal and oil, before seven three, Ginseng is to produced by using the same active Ginseng and, when the easy action per the truth consequent appearance in court sacrificial offering as well as enhances the ability exercise. excellent used. per the truth consequent appearance in court sacrificial offering and Ginseng such activity in particular when the co-administration of a greatly enhance the capability exercise may be on a pattern electrode. A current Ginseng active as the per the truth it is a consequent appearance in court sacrificial offering and misfortune mote position[...] having high viscosity by using mixture of temperature change stress-induced cell apoptosis induction in producing a pharmaceutical composition for preventing temperature increases to minimize the error and to induction apoptosis even, harbor dues gun extinction enzyme expression is expected to be increased. Purpose of the invention if layer of an active Ginseng and per the truth consequent appearance in court sacrificial offering using a composition of matter comprising a temperature change according to stress-induced cell apoptosis induction expression of enzymes reduce the, Ginseng active increasing the expression harbor dues gun extinction enzymeper the truth consequent appearance in court sacrificial offering and according to the temperature changes that contain as the active ingredient an apoptosis induction expression inhibition and harbor dues gun extinction enzyme medicinal compositions for expression amount by a rope.. the purposes, active Ginseng and per the truth consequent appearance in court sacrificial offering according to the temperature changes that contain as the active ingredient an apoptosis induction expression inhibition and harbor dues gun extinction enzyme in pharmaceutical compositions for increasing the expression, said active Ginseng current 100 parts by weight to 20 parts by weight said per the truth consequent appearance in court sacrificial offering 5 characterized by controlled by a use for goods is achieved by pharmaceutical compositions. Wherein, said active Ginseng a class of novel in admixture are involved in, said mixture citric acid, salt, [...], magnesium stearic acid, silicon dioxide, mannitol, starch further comprises, said active Ginseng current 1000g 158g citric acid to, salt 114g, [...] 1.99g, 152g magnesium stearic acid, silicon dioxide 76g, 5045g mannitol, starch 5286g for including it is preferred that a. Furthermore, said composition is an oral form [...], said oral [...], granular, formulations, powder type, syrup type, capsule and is chosen from the group consisting of mixing, said 25 to 50 mg/kg oral dose constitutes a [...] it is preferred that a. Constitution of the invention to the second junction portion per the truth consequent appearance in court sacrificial offering and Ginseng active according to a composition of matter comprising a temperature change using according to stress-induced cell apoptosis induction expression of enzymes reduce the, harbor dues gun extinction enzyme capable of increasing the expression of the.. And order of manufacturing method according to an embodiment of the present invention composition also Figure 1 shows a, Also Figure 2 shows a Western blotting for test data of order and, Also 3 and Figure 4 Western blotting by electrophotographic and a graph is indicative of the experiments. Reference to hereinafter drawing per the truth consequent appearance in court sacrificial offering and Ginseng active according to an embodiment of the present invention includes compositions (hereinafter, ' AGS' assembling and welding steps) described a detail the. Active Ginseng current (Active ginseng) a misfortune mote position (Actigin) to obtain high pressure and, after washing the current Ginseng the invention also provides for a heat sterilization and fume pasteurization crossroad.. A class of novel Ginseng wherein Ginseng, wild, sheep harboring a wood, coal and oil, Mn11-mn17 a wood, coal and oil, firearm a wood, coal and oil, before seven three, and Ginseng selected from the group consisting of mixing is preferably not less. The thermal treatment at a temperature of 110 to 125 °C formed 10 to 20 minutes, is repeatedly carried out with 3 to 4 times it is preferable that the. Less than 110 °C temperature heat treatment when heat treatment is not, 125 °C of Ginseng exceeds the can be surface. Perform a heat treatment when in addition the invention also provides for a heat steps 2 when Ginseng is relatively expensive can be having a timer therein of, 5 one time exceeds the cleavage of by-active ingredient a low content of active ingredient connected the address generator assigns addresses. The oxide pattern and the photoresist pattern of a product that is prepared is misfortune mote position (Actigin) emits the light from a light source. per the truth consequent appearance in court sacrificial offering[...] (Angelica gigas Nakai Extract) which means that the (Agnex), form a family of 40 mesh (mesh) hereinafter a per the truth ear the moisture content so that a large amount the method is characterized by drying a 1 to 10%. The moisture content at less than 1% to the outside easy drying, exceeds the 10% at a later step may adversely affect the. Milling which has an agitator comprising a 200 per the truth in ear Angelica gigas Nakai having 100 parts by weight to 500 parts by weight of adding an alcohol to extracts the under succussion occurs the, concentrated under the same per the truth ear misfortune obtain the having high viscosity. The liquid as well as and remaining of part that is fitted with an aperture. per the truth ear misfortune 100 parts by weight alcohol per the truth ear misfortune the reinserted 200 to 500 parts by weight of the major component in the steps of dissolving a -10 to -30 ° C. the composition is left for temporal extent 10. per the truth ear misfortune re-dissolution of alcohol and the movable member is driven by or minor non-main and remaining of alcohol insoluble in and has a present. Leaving temperature sources other than a desired when said end lies above the -10 ° C and different components of and to realize of melting together, main -30 ° C transmitted to temperature than precipitation with impurity can be one pulse. Wherein the principal component per the truth ear misfortune (Decursin) without causing any side effects, drug with decursinol angelate (Decursinol), decursinol angelate (Decursinol angelate) and selected from the group consisting of mixing is preferably not less. 5.0 to and precipitate insoluble in alcohol through of the resulting precipitate is centrifuged to through separation of after removing the supernatant, obtains and makes, the drying by evaporating supernatant, and to obtain concentrate main component. Citrus main such alcohol is previous step dissolved-centrifugal separator-evaporator perform a drying process with a purity 70% or more Angelica gigas Nakai having [...] obtain including the major component. Wherein acid and alcohol are Pharmacopoeia or ethanol ethanol (Ethanol) .most preferably is. The completely misfortune mote position suspended in alcohol, citric acid, salt, [...], magnesium stearic acid, silicon dioxide, is added to this additional and starch to mannitol misfortune mote repose of souls copolymer prepare. [...] to ethanol herein adding [...] suspended, through a stirring same a uniformly mixed to prepare mixture AGS. After, using granules drying the mixture AGS the granules of making and, in 60 °C granules are produced after 10 to 20 temporal extent manners grudge, 2 additionally in 80 °C was very dry or more time. AGS composition mixing [...] / misfortune mote position the thus produced planar metallised textile structure: a buffer. Wherein the AGS which made of oral administration, such oral [...] granular, formulations, powder type, syrup type, capsule type preferably. Oral administration the AGS misfortune mote position made of 100 parts by weight 5 to 20 parts by weight of an [...] combined into a combined flow and is preferably, doses the 25 to 50 mg/kg it is preferred that a. Less than 5 parts by weight when [...][...] which mix effect, 20 parts by weight of well drying exceeds the formed granules in addition do not can be prevent troubles from occurring or the like. In addition when less than 25 mg/kg doses is pharmaceutical efficacy which, do not appear well, exceeds the 50 mg/kg doses of a consumer many. may result in a. < 실시예 1>: AGS manufacturing Active sheep harboring wild 1L ethanol the completely 1000g misfortune mote position suspended in section. 158g citric acid herein, salt 114g, [...] 1.99g, 152g magnesium stearic acid, silicon dioxide 76g, 5045g mannitol, starch 5286g been produced with at misfortune mote repose of souls copolymer by the addition of. A variety of content such components, identified through test that is optimal efficacy is content of. [...] in 72% purity herein 167g to ethanol melt to 100 ml by adding [...]with misfortune mote repose of souls copolymer which is uniformly mixed with through agitation, then granulated by drying the granules using the granules using manufacturing processes and the cost of production. 60 °C granules are produced in drying the 16 time or more, 2 additionally in 80 °C was very dry or more time. < 실시예 2>: Western blotting SD (Spargue dawley rat) shielded experiment divided into group 3 of embodiment the control group and each of the groups is the n bit parallel data inputted the 4 mary (Control), voice the control group (Negative control) the 5 mary, soldiers experiment to experiment (Treatment control) AGS treatment group the 5 mary the embodiment. SPF (Specific pyrogen free) chamber experiment corresponding advertisement based on the shown embodiment, the control group was nonperiodic period available adaptive weeks 1 23 °C temperature, 55% relative humidity in the n bit parallel data inputted growth daytime 5, the control group and voice group experiment the morning the long distance of the afternoon of time after 10 2 32 °C temperature, relative humidity 75% free [...] the embodiment in the n bit parallel data inputted. weeklast week a 5 2 3 the morning both group of time after 10 had to dosage of the long distance of the afternoon. Ideographic is experimentally such constitution: i.e., "straight touch" to 1. 5 week or two, such as an organ, then both [...]mercy killing SD was an aqueous solution of. Also as shown in 2 liver light using a buffer for melting (Lysis buffer) buffer cis lighting reabsorbing homogeneous in 10 minutes after separating the supernatant by centrifuging to produce a high protein analysis of to embodiment 96-well plate it was determined that amount of specific proteins using transition metal. Then SDS-PAGE electrophoretic device of specific proteins using transition metal through Western blotting and separating the transferred protein at the membrane (membrane) antibody 1, for identifying antibody response through (Primary antibody), each of the same after the protein film a control Actin, apoptosis induction enzyme Fas, Bax, Bcl-2 Caspase-3 and-apoptotic enzyme reacted to. Then 2 and wash balloon same antibody (Secondary antibody) confirming each-antibody reaction through also the result is a corresponding advertisement based on the shown 3 and 4 shown in an.. Also decodes a result such as 3 and 4, the control group (CON) 100% of the control group during the analysis in this case high temperatures compared to the to the control group (NC) apoptosis induction enzyme Fas, Bax, 175% respectively Caspase-3,290%, 120% polyisocyanate as a resin curing agent increases, the 90% Bcl-2-apoptotic enzyme levels have shown a resulting. However the speech group processing AGS Fas 60%, Bax 160%, the n bit parallel data inputted second Caspase-3 80% length the Bcl-2 have been increased to 130%. The results indicate that in vivo due to a variation in the weather is AGS apoptosis induction expression of enzymes in a half-the blade portion on the reference face, -apoptotic enzyme for high expression of and increase the survival of the cell, thereby.. , In a temperature according to the climatic caused by changes in reduced mortality included in a weight percent. The present invention relates to a pharmaceutical composition for increasing the expression of anti-apoptotic enzyme and for inhibiting the expression of apoptosis-inducing enzyme with respect to the temperature change, comprising active ginseng and a refined extract of Angelica gigas Nakai as an active ingredient, wherein 5-20 parts by weight of the refined extract of Angelica gigas Nakai are mixed with respect to 100 parts by weight of the active ginseng. Accordingly, provided are effects in increasing the expression of anti-apoptotic enzyme and reducing the expression of apoptosis-inducing enzyme by stress with respect to the temperature change. COPYRIGHT KIPO 2016 Active Ginseng and per the truth consequent appearance in court sacrificial offering according to the temperature changes that contain as the active ingredient an apoptosis induction expression inhibition and harbor dues gun extinction enzyme in pharmaceutical compositions for increasing the expression, said active Ginseng current 100 per the truth consequent appearance in court sacrificial offering said parts by weight 5 to 20 parts by weight pharmaceutical compositions characterized by controlled by a use for goods. According to Claim 1, a class of novel Ginseng active said in admixture are involved in, said mixture citric acid, salt, [...], magnesium stearic acid, silicon dioxide, mannitol, starch to characterized by further including pharmaceutical compositions. According to Claim 2, said mixture, said active Ginseng current 1000g 158g citric acid to, salt 114g, [...] 1.99g, 152g magnesium stearic acid, silicon dioxide 76g, 5045g mannitol, starch 5286g to characterized by including a pharmaceutical compositions. According to Claim 1, said composition is an oral form [...], said oral [...], granular, formulations, powder type, syrup type, capsule and mixing characterized by selected from the group consisting of pharmaceutical compositions. According to Claim 4, said 25 to 50 mg/kg oral dose constitutes a [...] characterized by provided that the pharmaceutical compositions. Group RAT (mary) Temperature (°C) Humidity (%) Dosage The control group 4 23 55 - Voice the control group 5 32 70 - AGS treatment group 5 32 70 AGS
