COSMETIC COMPOSITION FOR IMPROVING SCALP HEALTH, AND METHOD OF PREPARING SAME

08-12-2017 дата публикации
Номер:
KR1020170135442A
Принадлежит:
Контакты:
Номер заявки: 00-16-102067375
Дата заявки: 31-05-2016

[1]

The present invention refers to, the amount of sebum secretion by the scalp hair is optimized to's number can be grown in the environment as well as hair enhancement and growth can be activated by growth factor, can be improving the skin health of the scalp cosmetic composition comprising the same and manufacturing method are disclosed.

[2]

The surface of the body covering the scalp where hair is growing and the cranial plugs can be of skin tissue, external physical irritation and chemical changes impact protecting the inside of herbicides, hair follicle and rich nerve distribution and more compact than other skin blood vessel, in the scalp hair is oxygen supply for supplying oxygen to the vasculature [...] microspheres can be grown in the nutrient environment number [...] substrate.

[3]

The stoma such harmful substances and also to in-vivo scalp, skin keratin and TiO2 sebum blended if UV rays to generate wherein the tapered pores prevents inflammation scalp hair is to be coated. In addition, other skin covered with scalp hair is vulnerable to the bacteria and high humidity.

[4]

The sebum secretion amount being suitable for a healthy and resilient, which is furthermore characterized scalp color clear transparent, the generation of the scalp door number dry scalp, oily scalp, sensitive scalp, scalp-dandruff, scalp hair scalp-appearing in the form such as can be such number is equal to scalp-door. Door-type of scalp under number heat such as disclosed.

[5]

First, as dry scalp normal keratinization of action is not visible features which make the scalp skin aging is thickened. Oil, which is free to radiance [phwu three [phwu three very much drying water balance at the second step. In addition to removing hair keratin or impaired blood circulation to the skin and to induce the stacked disapproval.

[6]

In addition, stores and illustration and keratin is entangled with a sebum is oily scalp scalp sebum secretion of a condition to scalp dandruff, pin pores exudate from the coating to the tip of the same effective toxin administration to a hair causing growth of hair also other.

[7]

The sensitivity to capillary blood vessel extending from the exterior is provided as a sensitive scalp scalp irritation or even it picks, a weak heating phenomenon serves to be inserted into each other. Carbostyril derivatives for scalp surface, inflammation and elongate capillary vessel can be visible to identify hair is very elongated disclosed.

[8]

Removing the hyperplasia of cancer-dandruff scalp dandruff accompanied itch and stacked, and are divided into dry shampoo resistance shampoo. Through the resulting dry shampoo a scalp dry to form and can be described, the oily dandruff sebum keratin is a clinging type etc..

[9]

Hair scalp hair scalp hair is best life period which does not at the time of being-of said substrate. Temporarily attaching hair when hair is started while uncovering the scalp hair leads to represent a red ton tapered anti-microbial substantially free from such features.

[10]

In particular, the age group of 50 hair to hair for example 20 ∼ 30 to Young layer after a stage to recent considered him off and reporting the increase in population, related industry about 6 million female person according to one or more hair distress ∼ 7 parts per million population occupies 3 parts per million in name and a secrete number indicate female hair etc..

[11]

This is stress generally typical hair, shampoo or mousse excess use, permanent or dyeing and dryer by using hair with hair, removing the unbalance of a sebum secretion, male hormone action excess snow, excess sebum secretion hypothesis, blood circulation failure snow, peroxide, etc. scalp bacteria degradation snow, due to high heat a serious illness, ingestion of anticancer number and various anti thyroid number, administration of oral contraceptive use, the unbalance of a nutrition, ingestion of food, genetic factors or the like is cited.

[12]

Male and female hair somewhat even differences which, in the case of male alopecia, 95% based on genetic predisposition attributed at least two male hormone excess secretion. The same male hormone testosterone (Testosterone) was secreted in vivo specifically described specific enzyme (DHT: Dihydro-a Testosterone) converted into material that the magnetron d high draw reel [su toss reel which, testosterone is activated if the milk two or three guns coming into contact discoloration of active male hormone DHT (Hair Follicle Dermal Papilla Cell) changes into a substrate. The, DHT concentration becomes lower than the water-soluble relative hair follicle while shrinking catalyzed progress quickly are disclosed.

[13]

While, even in the case of female hormone secreted female alopecia caused major DHT acting hair follicle destruction and female had but a relatively DHT billion number of action to other.

[14]

It number method whereby such topical application, oral dosage number, health food, gene surgery, hair transplant surgery method such as a dry gas is circulated is alternative medicinal and without intending to be limited, according to the treatment method or material is deemed satisfactory cladding having a known, such hair prevention, for spraying of hair growth or hair cosmetic composition to improve with use of commercially available number and number but when existing data transmitted to the scalp is in many cases used as when is mainly composed of chemicals if the maxims. In the case of hair which has been subjected in addition said FDA approval number body caused by unbalance of improvement when applied whereby reduced sexual or allergy, depression, such as local inflammation in an unexpected and applied through the risk disclosed.

[15]

Said as described, this is hair of various disclosed. Chick lesions can be due to cope with etc. [hyel travel gear defile or pressing down if not as nutritional material number, or physiological material causing a fault due to the excessively accumulated in the event of abnormalities of scalp osmotic of homeostasis, cell death or more hair follicle cycle of the mold, excess sebum secretion by keratinocytes, waste to scalp environment deterioration, bacteria etc. and a grammatical function according to deterioration of the final result and reason for too many hair scalp function to progress because only one door number not solve hair is improved airs. The various cause hair can improve the efficacy of synergistic effect and the plate and relieving spraying such that composite to 10sup16.

[16]

Publicized patent number 2016 - 0054087 call (2016. 05. 16 Disclosure) in skin-irritation, hair growth promoting hair growth promoting effect and oil pen hit [pheyp tie [tu connector containing the same relates to cosmetic composition, specifically cafe [...] pen hit [pheyp tie [tu skin-irritation by chemical coupling kite deficiency, and promoting hair growth to a cafe hair cosmetic composition containing the same growth promoting effect by oil pen hit [pheyp tie [tu and in number to 1.

[17]

Registration patent number 1541533 call (2015. 08. 28 Publication of registration) extract in pleuropterus multflorus, resin extract, extract, IGF-a 1 (Insulin like Growth Factor provided 1), PDGF (Platelet derived growth factor) and MSM (Methyl Sufonyl Methane) further including a composite composition including active ingredient loss prevention, growth promoting, dandruff cosmetic composition to be scalp inflammation when generating billion number number.

[18]

However, such known in the case of the peptide and/or growth factor protein component contained in said cosmetic composition in the case of skin penetration scanning substantially preventing or spraying satisfactory improvement hair according to the handful.

[19]

Publicized patent number 2016 - 0054087 call (2016. 05. 16 Disclosure)Registration patent number 1541533 call (2015. 08. 28 Publication of registration)

[20]

The present invention refers to, excess sebum secretion by keratinocytes, waste to scalp environment deterioration, due to cope with nutritional material number [hyel travel gear defile can be supplied as inability of such number that can be caused by various scalp hair to prevent door through sebum secretion can be grown in the scalp hair is optimized and number [...] environment, hair growth and temperature so that the scalp where hair through activate health improvement efficacy [...] number as well as broadcast receiver.

[21]

In order to achieve a purpose of the present invention such as described above the scalp cosmetic composition for improving health, insulin-like growth factor (Insulin like Growth Factor provided 1), thymosin beta - 4 (Thymosin β 4) and oligopeptide comprising, the N - terminal amino acid is glycine (Glycine) and said oligopeptide, preferably a 10 - 15 amino acid length.

[22]

Insulin-like growth factor 100 parts by weight of said, thymosin beta 4 17 - 67 - 8 - 25 parts by weight parts by weight of oligopeptides can be, said insulin-like growth factor, thymosin beta 4 - oligomer compound is formed on the surface of the peptide can be stabilized.

[23]

the carrier, polymer (macromolecule), fine aggregate (microassembly), microparticles (microparticle), microspheres (microsphere), nano opening (nanosphere), liposome (liposome), emulsion (emulsion) or a combination thereof can be used.

[24]

Said cosmetic composition, so as to maintain the homeostasis of the inside and outside of a scalp cells [...][...] (hexose), polyhydric alcohol (polyhydric alcohol) and electrolyte compound is preferably further including including composite buffer, said composite buffer is, [...] 7 - 28 wt %, 2 - 8 wt % polyhydric alcohol, electrolyte compound 0. 23 - 1. 559 Wt % and from the others in that it is composed, said [...], polyhydric alcohol, electrolyte and not larger than the sum of 100 wt %.

[25]

Said cosmetic composition solution, suspension, emulsion, paste, gel, cream, lotion, powder, oil, soap, cleansing foam, shampoo, rinse, treatment, number type selected from the group consisting of wax and spray may have.

[26]

On the other hand, other embodiment forms of the present invention, N - terminal amino acid is glycine (Glycine) and, 10 - 15 amino acid peptide in the oligonucleotides having length number tank; said oligopeptide, insulin-like growth factor and thymosin beta 4 - number bath mixture by mixing step; and said mixture five first class, number surfactants, moisturizing number, conditioning number, anti-oxidation number, number more, growing number, number adjusting pH, buffer number, selected from the group consisting of colored number and with clause [lyo than the cosmetic composition step number bath; the scalp health for improving cosmetic composition including number can be high pressure liquid coolant.

[27]

In said mixing, an organic phase, an aqueous phase and a surfactant in a solvent mixed number said oligopeptide, insulin-like growth factor and thymosin beta - 4 after homogenization under high pressure is included, the central preferably, more preferably [...] (hexose), including polyhydric alcohol (polyhydric alcohol) and electrolyte compound than the composite buffer can be mixing.

[28]

The oligopeptides of the present invention can be grown in the sebum secreted by the scalp hair is number in the environment as well as improving circulation in scalp hair-growth promoting hair follicle activity through the base through a left is activated growth factor by spraying through improving hair prevention of loss prevention effect can be achieved.

[29]

In particular, peptide compositions of the present invention provide a high degree of safety and stability than oligopeptides existing condition for high absorbency of the scalp health improving effect on the skin as well as exhibits.

[30]

In addition, said insulin-like growth factor (Insulin like Growth Factor provided 1), thymosin beta - 4 (Thymosin β 4) formed on the surface of the form by inclusion and oligopeptides, free scalp irritation, by action at a high concentration is extracted be scalp through the scalp health improvement.

[31]

In a preferred embodiment through prior to detailed hereinafter of the present invention, the specification and claim terms or word range is not being interpreted and in defining or a pre-conventional sense, to meet the technical idea of the present invention should be interpreted semantics and general outline found each other.

[32]

The entire specification, any components that "comprising" when any portion, particularly the opposite substrate [...] number but without other components further can include other components which means that the other.

[33]

"Number 1", "number 2" to distinguish from other components such as components for the one term, these terms in rights by time is not with each other. For example, components can be termed component number 2 number 1, number 2 of the elements can be similarly designated number 1 component.

[34]

Each steps for facilitating the descriptor is identified as being used in identification code into a second code sequence but is described, it is apparent that providing language translators each steps in a particular order based on the specified order not or more can be embodiment differently. I.e., each step is equal to the specified order may be embodiment may be in the order of substantially simultaneously and the opposite embodiment embodiment may be disclosed.

[35]

The specification "hair" in the area where the source section are turned as it grows in all body, hair is I components in skin is "growth", "hair" is hair is normally should be present in an irradiation device may can be hair is means, such as the scalp means from falling out and consonant, hair or scalp hair is varied in attaching the "hair loss prevention prevention" means that the inner stop or can be attenuated.

[36]

[37]

In the scalp cosmetic composition for improving health and manufacturing method of the present invention hereinafter transmissions take with respect to the broadcast receiver.

[38]

First, the scalp cosmetic composition of the present invention for improving health, insulin-like growth factor (Insulin like Growth Factor provided 1), thymosin beta - 4 (Thymosin β 4) and oligo peptides can be a.

[39]

N - terminal amino acid is glycine (Glycine) 10 - 15 amino acid in said oligopeptide the length can be the range of, preferably glycine (Gly) (Ala) to N - terminal amino acid is alanine, valine (Val), leucine (Leu), leucine (lle) isocyanate, threonine (Thr), serine (Ser), cysteine (Sys), methionine (Met), aspartic acid (Asp), asparagine (Asn), glutamic acid (Glu), glutamine (Gln), lysine (Lys), arginine (Arg), histidine (His), phenylalanine (Phe), tyrosine (Tyr), tryptophan (Trp) or proline (Pro) 10 - 15 are successively selected in conjunction selected a preferred amino acid may be in the form disclosed.

[40]

In one example, said oligopeptide is Gly-a Gln-a Gln-a Lys-a Arg provided Ser-a Asp provided Arg a-Leu-a Asn-a Leu-a Ser-a Arg, Gly-a His-a Lys-a Gly-a Gin a-Leu-a Tyr-a Val a-Gln-a Len, Gly-a Gln-a Gln-a Lys-a Asp-a Val-a Tyr-a Val a-Gln-a Leu-a Tyr, Gly-a Glu-a Gln-a Lys-a Asp-a Val-a Tyr-a Val a-Gln-a Leu-a Tyr, Gly-a Gln-a Lys-a Gly-a His-a Lys-a Asp provided Val a-Leu-a Tyr, Gly-a His-a Lys-a Lys-a Lys-a Gly-a His-a Lys-a Gly-a His, Gly-a His-a Lys-a Lys-a Gly-a His-a Lys-a Lys-a Lys-a Gly-a His-a Lys-a Asp provided Val, Gly-a His-a Lys-a Gly-a His-a Lys-a Asp provided Val a-Gln-a Leu-a Tyr, Gly-a His-a Lys-a Lys-a Gly-a His-a Lys-a Glu-a Gln-a Arg-a Tyr-a Val or non-Gln-a Leu-a Tyr Gly-a His-a Lys-a Gly-a His-a Lys-a Lys-a Lys-a Gly-a His-a Lys as, and sequentially be a selected peptide sequentially coupled into amino acids.

[41]

Thus, the amino acid glycine (Gly) included in the cosmetic composition of the present invention starts with a peptide nucleic acid N - and, if predetermined amino acid glycine said predetermined 9 - 14 are sequentially engaged form which a user without using specifically defined, this aspect of the present invention cosmetic compositions and method, can be appropriately selected according to the state of health of the user or is used preferably.

[42]

More preferably said oligopeptides can be employed in the form of salt, this compound during final separation and positive number in an appropriate group or amino group as made by reacting, for example acid addition salt acetate, adipate, alginate, citrate, aspartate, benzoate, benzenesulfonate, bisulphate, butyrate, camphorsulfonate rate, adhesive paste sulfonate, d writing base nose four [thu, preparing phosphate, hemi alkylsulfate, heptanoate, process hexanoate, formate, fumarate, hydrochloride, hydro bromide, hydro iodide, 2 - hydroxy ethane sulfonate, lactate, maleate, mesh [thil sulfonate, methane sulfonate, me [phu opinion gun four [thu, nicotinate, 2 - naphthalene sulfonate, oxalate, pamoate, [...], it ladles, opinion pay [thu, 3 - phenyl propionate, peak rate, pivalate, propionate, succinate, tartrate, with oh reel [thu production, trifluoro acetate, phosphate, glutamate, bicarbonate, but it will be a fortune car roh a [thu and para - [...], limited to are not correct.

[43]

In addition, examples of said acid addition salt can be used to form hydrochloric acid, hydrobromic acid, sulfuric acid and phosphoric acid such as an inorganic acid and oxalic acid, maleic acid, succinic acid and citric acid can be a an organic acid such as, limited to are not correct.

[44]

Preferably oligopeptides of the present invention can be in the form of tree being composed of acetate salt or acetate salt using oligopeptides.

[45]

In addition, the scalp cosmetic composition of the present invention for improving health and thymosin beta 4 - insulin-like growth factor included in the scalp hair through circulation-improving agent to promote growth by preventing hair through hair follicle activity or strengthened, and hair growth may affect skin tissue growth in 2000.

[46]

Bone, muscle, nerve, vascular, to form tissues such as damage cells as well as cell death billion number known to help playback of insulin-like growth factor (Insulin like Growth Factor-a 1) is involved in generation of new tissue formation as well as cells serve as growth hormone may help improve band pulse excimer laser capable, preferably by adjusting the hair follicle growth data in a keratinous cell growth and maintain can be preventing growth of hair.

[47]

Said thymosin beta - 4 has been found from bovine year 1981 (Thymosin β 4) is reactivated, which are combined to a molecular weight of 43 amino acid 4,982 Da, the theoretical isoelectric point 5. 1 72 As a weakly acidic proteins known. In addition, glutamine acid like lysine residue 72 amino acid does not present, all voice charge least the aspartic and two glutamic acid 11, both [...] arginine acid residues and 9 pieces, said thymosin beta - 4 of the secondary structure of spiral structure 2 including a virtual 2 that known.

[48]

The thymosin beta - 4 cells and moving of the differentiation is important modulators executes, the recovery of a known angiogenesis and wound is extracted changed, by increasing the size and distribution of the size of the hair follicle and hair vessel (hair vessel) by can be hair-growth promoting.

[49]

The scalp cosmetic composition of the present invention for improving health insulin-like growth factor 100 parts by weight, thymosin beta 4 67 - 17 - 8 - 25 parts by weight parts by weight of oligopeptides can, said content range through scalp hair growth and activate oligopeptides is growth factor in improving circulation as well as enhance the activate hair follicle, sebum secretion amount by the optimal environment for growing number hair is to be repeated is drawn through the experiments provided, fit range when said scalp and hair growth, according to spraying cannot be obtained or a content amount from the apparent effect cannot exceed.

[50]

In addition, the scalp cosmetic composition of the present invention for improving health mentioned growth factor is insulin-like growth factor and said thymosin beta 4 - in addition to or improving the skin health of scalp hair growth and promoting hair growth, preventing hair can be epidermal growth factor (Eepidermal growth factor, EGF), transforming growth factor (Transforming growth factor-a a, TGF-a a) - a, - b transgenic growth factor (Transforming growth factor-a b, TGF-a b), fibroblast growth factor -2 (Basic fibroblast growth factor, bFGF), growth factor (Keratinocyte Growth Factor, KGF), stem cells growth factor (Stem Cell Factor, SCF), platelet derived growth factor (Platelet derived growth factor, PDGF), vascular endothelial growth factor (Vascular endothelial Growth Factor, VEGF) and basic fibroblast growth factor (basic Fibroblast Growth Factor, bFGF) in appropriately selected from the group consisting of needed can be further comprising, oligopeptides of the present invention activate the board growth and such growth factors most suitable scalp hair growth can be resin and maintaining.

[51]

Preferably keratinous cells involved in differentiation and regulate production and a new hair growth, as well as act as modulators important interaction between immortalized epithelial - of manufacture produced from cell damage and protect hair cells that can prevent a keratinocyte growth factor (Keratinocyte Growth Factor, KGF), plasma of capillary and promoting the movement of division and increasing the protein transmembrane, as well as hair vessel involved in angiogenesis new vascular maintenance by increasing the size and distribution of the size of the hair follicle and (hair vessel) by improving hair to promote growth vascular endothelial growth factor (Vascular endothelial Growth Factor, VEGF), collagen, elastin synthesis of basic fibroblast growth factor increase hair growth can be, more preferably said cell growth factor 70 - 100 parts by weight of 100 parts by weight of insulin-like growth factor, 80 - 120 parts by weight of basic fibroblast growth factor 70 - 130 parts by weight of a vascular endothelial growth factor can be.

[52]

Said insulin-like growth factor, thymosin beta 4 - oligomer compound is formed on the surface of the peptide emulsion base is included in the present invention cosmetic composition stabilized state only wishes to obtain 106. morning fair number effect can be achieved. Preferably polymer (macromolecule), fine aggregate (microassembly), microparticles (microparticle), microspheres (microsphere), nano opening (nanosphere), liposome (liposome), emulsion (emulsion) or a combination thereof formed on the surface of said insulin-like growth factor, thymosin beta - 4 and oligopeptides inclusion by the form, as well as effects due to emulsion base the scalp can impart higher effect in scalp thereby improving absorption rate can be achieved.

[53]

The scalp cosmetic composition of the present invention for improving health balance of energy used by the inside and outside of scalp cells [...] won monosaccharide effectively allowed to penetrate into the dermis to promote blood flow as well as neurotransmitter secretion in scalp by [wan axial misfortune could aid in spraying can be further improved.

[54]

Said electrolyte compound generally used in cosmetic composition as well as inorganic absorbency of scalp skin allergic reactions and stimulation supply when for example it is possible to specifically defined user without using enabled, preferably sodium chloride, potassium chloride, calcium chloride and sodium sulfate can be more preferably comprising at least one of sodium chloride 0. 1 - 1 Wt %, calcium chloride 0. 01 - 0. 055 Wt %, calcium chloride 0. 01 - 0. 034 Wt % and sodium sulfate 0. 11 - 0. 47 Wt % can be comprising.

[55]

Said electrolyte compound such as sodium chloride is an osmotic cells to 0. Preferably said 1 wt % 1 wt % hereinafter which cover an osmotic [...] rather by a difference inside and outside of the cells when collapsed and balance can be exacerbated by spraying, said sodium chloride ion salt is generated by 0. Less than 1 wt % when said composite buffer included in case the cell can be used within cells of secondary surfactant [...] is constructed as a nutrient for the efficiency of active transport number thereof can not energized.

[56]

Said electrolyte compound is ionized from potassium chloride potassium cells present, one number contained in a number of high density and high concentrated sodium ions and electrical equilibrium cell external misfortune cation by maintaining a fixed relationship of one active transport and plays an important role, external misfortune of inositol phospholipids in cell plasma membrane calcium ion diaryl [...] acid number to activate keratinocyte proliferation of induced by generating a protein kinase or can. In addition, sodium sulfate and sodium bicarbonate buffer to generate said by inducing a diuretic effect in vivo in lines on [...] capable of maintaining air pressure of homeostasis.

[57]

The, said electrolyte compound from which maintains the homeostasis of the body included in vivo linear body and since the scalp surface and epidermis allergenic response in the power generation [...] appearing when a maintain equilibrium plasma membrane material transport [...] said surfactant composition as well as the drawer as well as oxygen, protein, lipid and other saccharides by improving the efficiency of the scalp hair health and enables the supply can be prevent.

[58]

Said [...] (hexose) with 6 carbon atoms as D - monosaccharide is glucose (D non-glucose), glow five [su [...] D - D - (D non-gulose) (D non-mannose), galactose (D provided glalctose) D -, D - (D provided idose) without deterioration, with mask five [su D - (D non-talose), D - (D non-allose) with egg five [su, the [thu which it will know food D - (D non-altrose), D - fructose (D-a fructose), D - and L - (L-a sorbose) the small [pu see the [su another family toe five [su (D non-tagatose) can be selected from the group consisting of one or more, preferably D - glucose (D non-glucose) and D - by weight of fructose (D-a fructose) can.

[59]

This external misfortune layer because of the movement of the scalp cells in said D - fructose cellular into cells and to dispose of used energy, due to the osmotic pressure of times said D - glucose (D-a glucose) for passage cells of 2 step hereinafter by, intracellular nutritional source number ball so that hair growth is extracted be. In addition, present and an epidermal surface scalp bacteria, in particular fluid flows through the scalp health improving hair growth of dermatophytes help be is set up.

[60]

This [...] 7 - 28 wt % preferably incorporated in said composite buffer, said desired effect and when the target is to the number of copied [...] having low metal content, content when content according to the output greater than increasing the effect as well as increased viscosity exceeds showing division of the user in use oily feeling, that excels in, feeling of use can be heavy feeling may cause a decrease in disclosed.

[61]

Said proved polyhydric alcohol (25 °C) solid shape, generally obtained by reducing a carbonyl group of saccharides can be preferably maltitol, sorbitol, erythritol is expense, mannitol, arabitol, it will go, [lak the mote [thol, xylitol, processes for the preparation of at least one or more from the group consisting of [...] and inositol can be selected.

[62]

More preferably cosmetic composition that excels in excellent feeling of use without feeling when a stiffer and/or sorbitol and [...] [heyk cow five [su and using said cell energy can be absorbed in the scalp with hair is processed used could help as well as simultaneously involved in nucleic acid biosynthesis of even by clause ketone by improving lipid metabolism due to said scalp skin and epidermis help can be preventing hair cells.

[63]

The polyhydric alcohol may be included in said [wan axial misfortune to said 2 - 8 wt %, this effect cannot be obtained when expected amount less than 2 wt % and, when spraying the composition of the present invention viscosity index of greater than 8 wt % for improving user included in use that excels in or hair cosmetic composition when applied to a weighed hair is perceived feeling of use may cause a decrease in disclosed.

[64]

The scalp cosmetic composition of the present invention for improving health aspects and method further comprises other ingredients used according can be e.g., sterilization number, antiseptic number, growing number, more number, fixed number, number excipients, colored number, stabilizing number, number adjusting pH, buffer number, number of appearing (tonicity agent), for number, anti-oxidation number, an ultraviolet number, determining deposition prevention number, vesicle number, a number is formed by the adhesive and bad number is cited.

[65]

Said sterilization number is not one specifically number, can be appropriately selected according to the purpose. For example, it cuts well the nose [nyum chloride (benzalkonium chloride), folds of the cationic surface-active agents such as cetylpyridinium chloride (cetylpyridinium chloride) number [...] chloride (benzethonium chloride) and number flow tides.

[66]

Preserving said number is not one specifically number, can be appropriately selected according to the purpose. For example, p - hydroxy benzoate ester (p a-hydroxybenzoate esters), butanol (chlorobutanol) and the [ley which will grow it will doze (clesol) pin is chloro.

[67]

Growing said number, bar and more particularly number number number is not one, can be appropriately selected according to the purpose, for example, starch, dextrin, cellulose, methyl cellulose, ethyl cellulose, carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, carboxymethyl starch, or jellies, sodium alginate, ammonium alginate, alginic acid propylene glycol ester, guar gum, locust bean gum, gum arabic, ammunition gum, gelatin, car number in, polyvinyl alcohol, polyethylene oxide, polyethylene glycol, ethylene/propylene block polymer, sodium polyacrylate and poly [...] 2000. They can be used alone or in combination of at least one of 2.

[68]

Coupling said number is not one specifically number, can be appropriately selected according to the purpose, for example, water, ethanol, propanol, stage syrup, glucose solution, starch solution, gelatin solution, carboxymethyl cellulose, hydroxypropyl cellulose, hydroxypropyl starch, methyl cellulose, ethyl cellulose, shellac, calcium phosphate and poly [...] 2000.

[69]

Said colored number is not one specifically number, can be appropriately selected according to the purpose, for example, be titanium oxide and iron oxide.

[70]

Stabilizing said number is not one specifically number, can be appropriately selected according to the purpose. For example, coating space [thu (tragacanth), your big black (gum Arabic), gelatin (gelatin), soddy [...] fatigue snow pit (sodium pyrosulfite), EDTA, the pin is of cholesterol (thioglycolic acid) thio the glycol [lik it buys [...] (thiolactic acid).

[71]

Adjusting said number and said pH buffer number is not one specifically number, can be appropriately selected according to the purpose. For example, soddy [...] citrate, acetate and soddy [...] soddy [...] phosphate flow tides.

[72]

In order to specially number is not one of said number, can be appropriately selected according to the purpose. For example, chloride and glucose soddy [...] flow tides.

[73]

In addition, the contemporary improving and anti-against stress such as the scalp to stabilize and effect further includes a number can be added perfume, said perfume is added number menthol (menthol), bender oil (lavandin oil), this year when it will see nonuse (bisabolol), sorbitol (sorbitol), and selected from the group consisting of not more than 1 with [cu oil (rose hip oil) can be a, the number one are not disclosed.

[74]

Illustratively said menthol (menthol) is the scalp scalp blood circulation aids in place and the cool stream pro-acts, said bender has been imparted to simultaneously place the psychosomatic condition of oil (lavandin oil) ointment effective for treating damaged as well as the scalp skin regeneration flow tides and other industrial applications.

[75]

Adding said clause [lyo number is 0. 01 - 0. 03 Parts by weight of an preferably, 0. 01 Parts by weight of less than skin effect or the effect of the adsorption fixing plate and anti-case can be, 0. 03 Parts by weight if so can be scalp causes stimulation.

[76]

The cosmetic composition of the present invention art even number can be any number type typically number bath tank, preferably solution, suspension, emulsion, paste, gel, cream, lotion, powder, oil, soap, cleansing foam, shampoo, rinse, treatment, selected from the group consisting of wax and spray-number but the number can be bath is not limited.

[77]

More preferably the scalp cosmetic composition of the present invention for improving health number type paste, cream or if it is a gel animal oil, include esters of fatty acids, wax, paraffin, starch, space [thu coating, cellulose derivative, polyethylene glycol, silicon, bentonite, silica, talc or zinc oxide can be further, number type this powder or spray when the lactose, talc, silica, aluminium hydroxide, calcium silicate or polyamide powder is further included can be, in particular spray case additionally chloro [...], propane/butane or dimethyl ether can be further such as to expel the projectile.

[78]

Cosmetic composition with a solvent solution or emulsion of the present invention when the number type, number or number and device for solubilized is further included, is water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1, 3 - butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters flow tides.

[79]

Cosmetic composition of the present invention case number type suspension water, such as ethanol or propylene glycol liquid dilution number, box-ethoxylated alcohol, polyoxyethylene sorbitol esters and polyoxyethylene sorbitan ester such as suspension number, microcrystalline cellulose, aluminum meta [...], bentonite, agar or coating can be further includes space [thu and the like.

[80]

In addition, the scalp cosmetic composition of the present invention for improving health applied cosmetic compositions will generally comprise regions which may, i.e. scalp hair growth as well as requiring one end where or if can be applied. For example, trauma scarring due to turning on or administrates the site is a simple beauty effect to hair in a broad forehead or M type forehead, eyelashes or eyebrows and atrichosis can be used in the state of the loop.

[81]

An object of the present invention applied cosmetic composition include hair, hair ([...]), (wool, ige) eyebrows, eyelashes (wool, concubine wool), plot (wool), axillary turn, breast turn, [...], such as leg turn hair can be included.

[82]

[83]

On the other hand, other embodiment forms of the present invention, cosmetic composition for spraying the composition as improved manufacturing method, N - terminal amino acid is glycine (Glycine) and, 10 - 15 amino acid peptide in the oligonucleotides having length number tank; said oligopeptide, insulin-like growth factor and thymosin beta 4 - number bath mixture by mixing step; and said mixture five first class, number surfactants, moisturizing number, conditioning number, anti-oxidation number, number thickening, growing number, number adjusting pH, buffer number, number and with clause [lyo selected from the group consisting of colored cosmetic composition than the step number bath; can be a.

[84]

Said step of tank number oligopeptides, generally peptide synthesis method of a user without using enabled preferably rotates back specifically defined solid polymer synthesis can be heparin using peptide synthesis method, said method of acid or base sensitive functional groups through oligopeptides prepared by the number can be protected by α - amino group. At this time amino acid protecting group is peptide condensation reaction conditions and must have stable properties, without breaking or any chiral center extending peptide chain containing therein the possible properties without wetting ability for hereinafter [...] number must have other.

[85]

The, flue [...] (Fmoc) protecting group suitable useful 9 -, t - butoxy neel car step (Boc), benzyl neel jade hour car step (Cbz), biphenyl isopropyl - oxy neel car step, t - oh neel wheat jade hour car step, ISO neel step [lu neel jade hour car step, (α, α) - 3, 5 - dimethyl - [...], O - knit with phenyl opinion phenyl, such as 2 - cyano - t - butyl neel jade hour car step can be, in addition of the present invention with other known protecting group are available in a range this purpose nitrile 2000.

[86]

Oligonucleotides of the present invention most preferably 9 - (Fmoc) protecting group include amino acids used in peptide synthesis using flue [...] saver is provided can be.

[87]

In particular, in the case of amino acid residues include the oligopeptides of the present invention include N - methyl glutamic acid protector, and t - butyl (t-a Bu); when lysine, t - butoxy neel car step and (Boc); in the case of serine, 7t - butyl (t-a Bu) and; when threonine and the lot [ley five which will know [nin, t - butyl (t-a Bu) and; when cis lymphocytes, tree cefuroxime (Trt) but preferably, this not the limited to the present invention.

[88]

Solid phase peptide synthesis method in said, can be attached to C - terminal amino acid also relates to the solid support or resin. Useful for a suitable solid support include stepwise condensation - said synthesis reagents and reaction conditions used medium insoluble inert reaction deprotected material is preferably, for example, link or links it cuts the qualitative drill amine resin (rink amid MBHA resin) amide 4 - methyl amide (rink amid) implementation being.

[89]

In particular, a preferred solid support is commercially available from Novabiochem Corporation C - amide end against the autologous amyloidogenic polypeptides can be 4 - methyl amide link it cuts the qualitative drill amine resin.

[90]

C - end amide (amide) is dichloro methane, N - methyl pyridone (NMP) in a solvent such as DMF at a temperature of 10 °C to 50 °C or, preferably 30 °C in temperature condition, 4 - dimethylamino pyridine (DMAP) 1 to 24 hours, at the time of it cuts trillion trees oh it will doze 1 - hydroxy (HOBt), N - methylmorpholine (NMM), benzotriazole - 1 - yloxy - tris (dimethylamino) phosphonium hexafluoro phosphate (BOP) or bis - (2 - oxo - 3 - oxa neel the d it will doze) phosphine chloride (BOPCI) under the presence or absence of N, N'- the claw between d [heyk the thread car body already the [tu (DCC), N, N' - dee small pro the car body which will bloom already (DIC), [O - (7 - aza - 1 - yl Α [...] tip) - 1, 1, 3, 3 - tetra the methyl rain and dew [nyum it buys [phul in base gun [su pay [thu] (HATU) or O - benzotriazole - 1 - yl - N, N, N', N' - tetra (HBTU) activate carboxylic acid to the methyl rain and dew [nyum it buys [phul base oro gun [su pay [thu through condensation resin or solid support can be condensation (coupling, coupling).

[91]

When it cuts the qualitative drill amine methyl 4 - amide linkage solid support resin, Fmoc amino acid C - functional group is preferred as a protecting end before condensation class 2 amine solution, preferably 20% piperidine DMF solution when used in excess is used substrate. Said deprotected 4 - (2 ', 4' - dimethoxyphenyl - Fmoc - aminomethyl) lung stipend city oh set oh america ethyl resin desired amino acid condensation reagents are used preferably for the ADC adapted N - methylmorpholine (NMM) DMF to protected amino acid in a solvent, 1 - hydroxy at the time of it cuts trillion trees oh it will doze (HOBt) and O - (7 - aza - 1 - yl non) - 1, 1, 3, 3 - tetra the methyl rain and dew [nyum it buys [phul base oro gun [su pay [thu] (HATU), O - benzotriazole - 1 - yl - N, N, N', N' - tetra (HBTU) the methyl rain and dew [nyum it buys [phul base oro gun [su pay [thu, N, the claw between d [heyk the thread car body already the [tu N'- (DCC) or N, N' - dee small pro the car body which will bloom already the [tu (DIC) condensation reaction reagent such as oxide inclusion content.

[92]

In the present invention performed consecutive amino acids in the art widely known condensation associated directly manually or using an automatic peptide synthesizer can. In a preferred synthesis reaction conditions include Fmoc protected glycine monomer group class 2 amine solution, preferably piperidine deprotected by treatment, excess solvent washing with the desired condensation and sufficiently to protected amino acid are then added to each another 3 - 7 times molar excess, preferably DMF by reaction to proceed in a solvent, N - terminal amino acid is glycine (Glycine) number in oligopeptides can be high pressure liquid coolant.

[93]

Synthesis of oligopeptides of the present invention solid resin using the last step oligopeptides 1 continuously or want from a resin and manipulation of a stand-alone and the corresponding amino acid residue of at least one number oligopeptides respectively protecting groups can be deprotected. The wetting ability and number of oligopeptides present protector of deprotected resin moiety generally resin - coupling between the peptide cocktail reagent for cutting conditions include, e.g., styrene thermoplastic rubber (TFA), tree this cow pro the thread column which will bloom (TIS), it knows it will doze thio, d mote this year (EDT) dichloro ethane or methane mixed cocktail solution to act as a processing can be achieved.

[94]

The thus obtained mixed solution is kept in cold storage d ethyl ether by processing a precipitate excess solvent capable of generating disclosed. Centrifuging the precipitate obtained than completely precipitating the excess styrene thermoplastic rubber, tree this cow pro the thread column which will bloom, thio it knows it will doze, like number 1 and 2 or a narrow drain by a stand-alone more procedure d mote this year primary and solidify the precipitate can be achieved.

[95]

In this case, fully deprotected oligopeptide salts are water and mixed solvent and performance liquid chromatography (HPLC) acetaldehyde knight reel solvent phase can be separated using positive number. Separation using oligomeric peptide solution provides long-positive number completely concentrated followed by drying to obtain solid oligopeptides can be.

[96]

The above mentioned manufacturing method obtained by said solid N - terminal amino acid is glycine (Glycine) and, 10 - 15 amino acid peptide thymosin beta 4 - insulin-like growth factor and oligonucleotides having length mixture further includes mixing step, mixing temperature after 30 - 90 °C phase number surfactants, including water and organic phases solvent prepared by the number number surfactants by mixing said oligopeptide, insulin-like growth factor and thymosin beta - 4 is included mechanical stresses by homogenization under high pressure in 50 - 2000 bar formed on the surface by said oligopeptide, which number is in the form of insulin-like growth factor and thymosin beta - 4 emulsion can be bath inclusion, and cooling the same number can be high pressure liquid coolant mixture.

[97]

In which said [...] (hexose), including polyhydric alcohol (polyhydric alcohol) and electrolyte compound further comprises a composite buffer can be, essential component said mixture said oligopeptide, insulin-like growth factor, thymosin beta - 4 and composite buffer in addition to the other components according to the intended use without difficulty one skilled compound can be suitably selected.

[98]

Preferably five first class, number surfactants, moisturizing number, conditioning number, anti-oxidation number, number more, growing number, number adjusting pH, buffer number, selected from the group consisting of colored number and with clause [lyo than the cosmetic composition of the present invention a number bath and subjected to a high pressure liquid coolant spraying the composition for cosmetic composition number can be improved.

[99]

[100]

In hereinafter, example of the present invention embodiment herein disclosed. However of the present invention hereinafter preferred embodiment example has the category is limited to, a specification of the present invention if one skilled within the rights of the content several modified shape embodiment can.

[101]

[102]

[Attainments number]

[103]

Oligopeptide Number bath

[104]

Purchased from Novabiochem corporation 2 a-chlorotrityl chloride resin (per g 0. 6Mmol loaded resin) automatic peptide synthesizer in the briefcase. 15 Ml of DMF 5 minutes then sufficiently reacts (sweeling) into a resin solvent, adding 15 ml DMF solution (w/v) piperidine 20% piperidine DMF solution after stirring (shaking) number and a stand-alone, 15 ml of DMF solvent and 15 ml of MC after washing using a solvent, a solvent was 15 ml MC is performed again.

[105]

Fmoc-a gly provided OH 0. 5 Mmol, 1 a-O - benzotriazole - N, N, N'N' - 2 the methyl rain and dew [ni bud [heyk it buys [phul base oro phosphoric acid (1 a-O-a Benzotriazole-a N, N, N', N' - tetramethyluronium, HBTU) 0. 5Mmol, N, N - die isopropyl ethylene amine (N, N non-diisopropylethylamine, DIEA) 0. 5 Mmol anhydrous DMF 20 ml for 1 to 4 minutes with respect to the activated. After 30 minutes mixing resin and activated solution and conducting the binding reaction. 20 Ml MC and 20 ml DMF (piperidine) piperidine 20% DMF liver after cleaning the melting resin to 40 seconds by Fmoc protecting the number been stand-alone.

[106]

After washing the resin again thereafter predetermined order Fmoc protection of amino acid amino acid (Fmoc-a Gln (Trt), Fmoc-a Gln (Trt), Fmoc-a Lys (Boc), Fmoc-a Arg (Pbf), Fmoc-a Ser (tBu), Fmoc-a Asp (OtBu), Fmoc-a Arg (Pbf), Fmoc-a Leu, Fmoc-a Asn (Trt), Fmoc-a Leu, Fmoc-a Ser (tBu), Fmoc-a Arg (Pbf) order) for sequentially input to allow reaction behind the wafer, then full amino acid sequence of synthesis is complete, unreacted amine is contained in 10 minutes (shaking) using acetic acid anhydride and base mote [tin this DMF was stirred.

[107]

Unreacted amine is 2 - (9H-a fluoren provided 9 a-yl) ethylcarbamated for protected by 2 - (9H-a fluoren provided 9 a-yl) ethylcarbamate a-O-a succinimide by reacting 10 minutes using, resin mixture is added 20 ml MC 40 seconds and 20 ml DMF using cleaning-gate.

[108]

Omission solution [2% TFA (Trifluroacetic acid), trisopropylsilane 2%] having a marked Serial number [...] often after a phase 2 after maintaining the reaction time and has, by filtering and screening resin, applying more than one ether cold precipitation obtained oligopeptides derived after drying.

[109]

The oligopeptide obtained using 10% - 90% acetonitrile/25 - 35 ml/min flow rate over 100 minutes C provided 18 column of concentration of water gradient solvent system using phase HPLC using was a positive number.

[110]

[111]

[Experiment example 1]

[112]

Of oligopeptides Stability

[113]

In the body of the oligopeptides prepared by the number attainments said number in order to identify human keratinocyte cell line HaCaT stability using a scalp irritation cytotoxic skin by whether therefrom.

[114]

The HaCaT cell lines used to test said 37 °C, when the cultured in 95% CO2 incubator, culture vessel 85 - 90% of the visible area of the unneeded culture degree, then desorbs coefficient trypsin treatment cells, 5 × 103 cells/cm2 passaging to him. Cell culture is 10% Fetal Bovine Serum (FBS, GIBCO, Cat. No. , 26140 - 079, USA) and 100 U/Ml penicillin, 100 micro g/Ml streptomycin and added with Dulbecco's Modified Eagle Medium (DMEM, GIBCO, Cat. No. 11995 - 065, USA) was used. The 75 T-a flask are excellently (NUNC, Cat. No. 156499, Danmark) 0.50 to, cytotoxic test order 24 well plate (NUNC, Cat. No. , 142475, Danmark) test method was used.

[115]

5 × 103 cells/well in a 24 well plate using the index by hemacytometer human keratinocyte same after dividing it. In DMEM containing 10% FBS by 40 - 50% of the surface area of the culture vessel are cultured in the culturing time 48, 50 ppm respectively said oligopeptides, the FBS-a free DMEM containing 100 ppm 24 by replacing him as further time. Culture nor post-incubation 3 - (4, 5 a-dimethylthiazol-a 2 a-yl) - 2, 5 a-diphenyl tetrazolium bromide (MTT, Sigma M5655, USA) solution (2. 5 Mg/Ml) adding a 50 micro l him as further time 3. Then, has surpassed its full cell culture, dimethyl sulfoxide (DMSO, Sigma D2650, USA) per each well of 200 micro l processing 200 micro l been rapidly, by 100 (ELISA) and transferred to 96 well micro l takes 570 nm were measured absorbance in Enzyme provided Linked Immunosorbent Assay.

[116]

With reference to the strength of absorption showed cytotoxic extent using pure water to 1 the table in a display data is shown.

[117]

[118]

Cell toxicity effect (%)
Control (pure water)100
50 Ppm oligopeptides93
100 Ppm oligopeptides81

[119]

[120]

Said residual results of table 1, 5 × 103 cells per culture vessel by 40 - 50% of the surface area of the initial culture Well cultured in 50 ppm oligopeptides prepared by the number stored in said number attainments, regulated by adding 100 ppm compared cytotoxic is free has been identified. This, in the method of using rollers oligopeptides prepared by the number number attainments cytotoxic scalp irritation caused into each capable of.

[121]

[122]

[2 Attainments number]

[123]

Cosmetic Composition number bath

[124]

In oligopeptides prepared by the number said number attainments, insulin-like growth factor and thymosin beta - 4, [...] (hexose), polyhydric alcohol (polyhydric alcohol) and electrolyte compound including composite buffer, other ingredients such as for table 2 parts by weight of a cosmetic composition number was high pressure liquid coolant.

[125]

More specifically to other components may be mixed together, form a single phase by heating it to a high pressure liquid coolant 80 °C after number, 55 °C in oligo peptides, insulin-like growth factor, thymosin beta - 4 and composite buffer mixed with 1000 bar 3 times to cool high-pressure emulsifying device in the embodiment 1 - 3 and comparison example 1 - 4 processes information for cosmetic composition which number was a high pressure liquid coolant.

[126]

Comparison example 1Comparison example 2Comparison example 3Comparison example 4In the embodiment 1In the embodiment 2In the embodiment 3
Oligo peptides0. 762. 62-1. 860. 811. 862. 45
Insulin-like growth factor (IGF-a 1)10. 010. 010. 010. 010. 010. 010. 0
Thymosin beta - 4 (Thymosin β 4)4. 984. 984. 984. 981. 734. 986. 70
Composite buffer[...]D - fructose0. 140. 140. 14-0. 140. 140. 14
D - glucose0. 080. 080. 08-0. 080. 080. 08
Polyhydric alcoholSorbitol0. 060. 060. 06-0. 060. 060. 06
Electrolyte compound0. 00350. 00350. 0035-0. 00350. 00350. 0035
Remaining water0. 71650. 71650. 71651. 000. 71650. 71650. 7165
Other ingredientsCarbomer0. 0160. 0160. 0160. 0160. 0160. 0160. 016
A high pressure0. 0160. 0160. 0160. 0160. 0160. 0160. 016
Lung stipendiary hour ethanol0. 30. 30. 30. 30. 30. 30. 3
Menthol0. 010. 010. 010. 010. 010. 010. 01
Not secure pin number -60 hydrogel [...] castor oil0. 030. 030. 030. 030. 030. 030. 03
Be positive numberThe remainder of theThe remainder of theThe remainder of theThe remainder of theThe remainder of theThe remainder of theThe remainder of the

[127]

(Unit: total 100 G Reference)

[128]

[129]

[Experimental example 2]

[130]

Cosmetic Composition Sclerite absorptance Evaluation

[131]

2 Attainments in hair cosmetic composition prepared by the number of said number for transdermal absorption test was embodiment effects. Hair-less cavy percutaneous absorption skin to a test object 1 cm square2 Area dividing each sample after 0. 5 Weighing one gram to 4 times 30 minutes after tape stripping method not being available for processing the concrete mortar over his database. The surface of the skin after HPLC analysis was amino group content concentration percent by weight solvent. The result is shown in the table 3.

[132]

The high pressure liquid coolant to said number of comparison example 5 is identical to the number 2 attainments manufacturing method in the embodiment 2, without the use of high pressure liquid coolant by mixing high-pressure emulsifying device polysulphones with yellowness index to his number.

[133]

[134]

Comparison example 1Comparison example 2Comparison example 3Comparison example 4Comparison example 5In the embodiment 1In the embodiment 2In the embodiment 3
1 Times61. 248. 573. 167. 175. 851. 649. 547. 9
2 Times37. 133. 123. 137. 223. 030. 831. 233. 7
3 Times11. 017. 76. 79. 37. 017. 919. 020. 1
4 Times3. 49. 91. 12. 70. 015. 116. 717. 9

[135]

Experiment result, comparison example 1, 3 - 5 number of oligopeptides of the present invention to skin surface growth factor exists primarily in type and skin penetration does not occur the lower electrode and to selectively, in particular in the case of comparison example 5 were the lower substantially skin penetration does not occur.

[136]

While, in the embodiment 1 - 3 and comparison example 2 number of skin penetration occurs most into been can be ascertained in type release has occurred.

[137]

I.e., oligopeptides and insulin-like growth factor of the present invention, a preferred content like thymosin beta - 4 after mixing, cosmetic composition of the present invention in wall body by inclusion by making sure that the morning fair skin absorption of substantially elevated number were.

[138]

[139]

[Experiment example 3]

[140]

Cosmetic composition (the composition) functional evaluation

[141]

2 Attainments said number for identifying the composition of cosmetic composition prepared by the number in each said in the embodiment 1 - 3 and comparison example 3 months 1 - 5 together male and female adult [...] 50 name to a test object to be paid for smooth tracking therefrom.

[142]

[143]

Going, hair has been madeEven though the change free useIt recovers, hair had beenThe presence of hair are improved
Comparison example 18/5012/5021/509/50
Comparison example 21/503/5020/5026/50
Comparison example 312/5012/5023/503/50
Comparison example 410/5013/5025/502/50
Comparison example 59/5022/5014/505/50
In the embodiment 11/505/509/5035/50
In the embodiment 20/506/507/5037/50
In the embodiment 30/502/5010/5038/50

[144]

[145]

Said residual results of table 4, in the embodiment 1 - 3 of example serves to assist in the evaluation of hair as compared to 1 - 5 is also used for hepatocytes compared to [...] month can be.

[146]

While, in the case of example 2 compared to the highest oligopeptides content in aid assessment that is lower than the lower electrode in the embodiment 1 - 3 as well as improving hair rather, spraying or other specific frequency in use with a relatively good use feeling weighed aspect the composition is evaluated evaluation but was improved.

[147]

[148]

[Experiment example 4]

[149]

The oligopeptides The Cosmetic Composition (the composition) functional evaluation

[150]

In the embodiment 2 prepared by the number in said number on attainments, manufacturing method identical to said in the embodiment 2It becomes trillion number, Gly-a His-a Lys-a Gly-a Gin a-Leu-a Tyr-a Val a-Gln-a Len oligonucleotides having sequence peptide including in the embodiment 4, Gly-a His-a Lys-a Lys-a Gly-a His-a Lys-a Glu-a Gln-a Arg-a Tyr-a Val oligonucleotides having sequence peptide including embodiment using non-Gln-a Leu-a Tyr example 5 50 3 months each adult male and female [...] name for identifying the composition target trace and the composition therefrom.

[151]

Going, hair has been madeEven though the change free useIt recovers, hair had beenThe presence of hair are improved
In the embodiment 20/502/5010/5038/50
In the embodiment 40/503/5011/5036/50
In the embodiment 50/501/5010/5039/50

[152]

[153]

Said residual results of table 5, in the case of hair in the embodiment 4 and 5 in comparison with that in the embodiment 2 in aid to improve assessment were detected large not to confirm it.

[154]

[155]

, the scalp cosmetic composition of the present invention for improving health in the sebum secreted by the scalp hair is number can be grown in the environment as well as in improving circulation through the base of the hair follicle activity through scalp hair-growth promoting hair growth factor is prevention of hair left activate card, it is possible to used in stimulating and scalp, the scalp hair loss preventive action through the lower electrode at a high concentration is extracted be health improvement.



[1]

The present invention relates to a cosmetic composition which can improve scalp health by creating the optimal environment for hair to grow through controlling the secretion amount of sebum on the scalp, and by activating growth factors capable of promoting strengthening and growth of hair; and to a method of preparing the same. Specifically, oligopeptides contained in the cosmetic composition have the effects of improving scalp health and preventing hair loss by creating the environment for hair to grow through controlling sebum secreted on the scalp; by promoting hair growth through improving blood circulation in the scalp; and by strengthening the hair through activation of hair follicles, thereby activating growth factors that are effective in preventing hair loss. Particularly, the oligopeptides of the present invention are safer and more stable to use, have higher skin absorption than pre-existing peptide compositions, and thus show excellent effects of improving scalp health.

[2]

COPYRIGHT KIPO 2018



Insulin-like growth factor (Insulin like Growth Factor provided 1), thymosin beta - 4 (Thymosin β 4) and oligopeptide comprising, said oligopeptide (Glycine) and the N - terminal amino acid is glycine, 10 - 15 characterized in that the amino acid length, the scalp cosmetic composition for improving health.

According to Claim 1, insulin-like growth factor 100 parts by weight of said, thymosin beta 4 17 - 67 - 8 - 25 parts by weight parts by weight of the oligopeptides characterized, the scalp cosmetic composition for improving health.

According to Claim 1, said insulin-like growth factor, thymosin beta - 4 formed on the surface of the peptide may be stabilized in oligomer compound is characterized, the scalp cosmetic composition for improving health.

According to Claim 3, the carrier, polymer (macromolecule), fine aggregate (microassembly), microparticles (microparticle), microspheres (microsphere), nano opening (nanosphere), liposome (liposome), characterized in that the emulsion (emulsion) or combinations thereof, the scalp cosmetic composition for improving health.

According to Claim 1, so as to maintain the homeostasis of the inside and outside of a scalp cells [...][...] (hexose), including polyhydric alcohol (polyhydric alcohol) and electrolyte compound including a composite buffer characterized, the scalp cosmetic composition for improving health.

According to Claim 5, said composite buffer is, [...] 7 - 28 wt %, 2 - 8 wt % polyhydric alcohol, electrolyte compound 0. 23 - 1. 559 Wt % and from the others in that it is composed, said [...], polyhydric alcohol, electrolyte and water does not exceed the sum 100 wt % characterized, the scalp cosmetic composition for improving health.

According to one of Claim 1 to Claim 6, said cosmetic composition solution, suspension, emulsion, paste, gel, cream, lotion, powder, oil, soap, cleansing foam, shampoo, rinse, treatment, selected from the group consisting of wax and spray atomizing characterized having number type, the scalp cosmetic composition for improving health.

N - terminal amino acid is glycine (Glycine) and, 10 - 15 amino acid peptide in the oligonucleotides having length number tank; said oligopeptide, insulin-like growth factor and thymosin beta 4 - number bath mixture by mixing step; and said mixture five first class, number surfactants, moisturizing number, conditioning number, anti-oxidation number, number more, growing number, number adjusting pH, buffer number, selected from the group consisting of colored number and with clause [lyo than the cosmetic composition step number bath; including a, manufacturing method for improving health scalp cosmetic composition.

According to Claim 8, in said mixing, an organic phase, an aqueous phase and a surfactant in a solvent mixed number said oligopeptide, insulin-like growth factor and thymosin beta - 4 after homogenization under high pressure is included, characterized by cooling, manufacturing method for improving health scalp cosmetic composition.

According to Claim 8, in said mixing, [...] (hexose), polyhydric alcohol (polyhydric alcohol) and electrolyte compound characterized including composite buffer than the mixing, the scalp health cosmetic composition for improving manufacturing method.