Acaricide compositions.

The present invention relates to compositions which born aeari&j° and '"' ^ d-ably tlon" nsec treating 1° literi® and ancillary objects.

Allergies S the dust to a domestic~orennent does various forms, in particular asthma, also promulgated eyes and infections:

the skin. It has been established by many authors_{the n} such allergies UEs " have dug in many cases by certain moths and that beneficial effects could be obtained R.S. their eradication followed SROs preventive treatment to prevent.. return. It is well known one derivatives certain species of moths such · - ;·℮ the dermatophagoîdes, species culinae, pteronyssinus, glycyphagurdomest-to-ieusoarus * and wax are insensitive to insecticidal ordinary unterstanding pyréihrines and ddT. p-R-against them are believed sensitive comfortable subclass Acari aids such " UEs benzyl benzoate is widely used for the control of mange and the like.

In this case. benzyl benzoate is carried as an emulsion in the oru, where it is soluble, and the emulsion is. applied to the skin of the

™ thine^J '.

Such moths live and replicate frequently in bedding, for example, sheets, mattress and blankets and also in the house dust and various coatings. Found as frequently'd "ns to the nests of birds and by suites in the feathers and skin, TDC mammals and birds" ue in the products made therefrom. It would be orofitable treat these bedding and objects attachments for killing mites YES there come, or at least to prevent stay on the replicate. An inherent difficulty to treatment with benzyl benzoate is due to the fact unterstanding this product, although does not less than 320 °c boiling is more value so as apppreciable at room temperature. This evaporation is olur is high because of the temperature increase when the bedding is occupies, ainai bare in areas of hot climate. Accordingly, the, the RAR given protective product is temporary since it disnareît rarrar.ide have being evaporated "

There are comrositiona BARE to non-volatile •'? the benzoate^{the R} * i such benzyl or® that affected is described in the English Patent no. 1,368 ôd7 YES includes the addition year benzyl benzoate glycol polyalkylèno nonvolatile or a nonvolatile ILO ether ester. NC has ^ referee polyethlene glycols of molecular ooids survrior to P 000 because they mix at a higher temperature than the body and at ' are neither tacky nor. hygroexpansivity scopic. It is " pporu the I ' ^ oortant of avoiding the use of liquid carriers YES would have given an impression of moisture into the bedding. However, these eonraosition " have various disadvantages:

the R>

the j! a) the elyeols polyallcyiene are soluble in water W + - by ¹ j. decry, they are susceptible to mildew with perspiration from the L i * j 1 ·οοοη ™ χ + γ ¾ bed. Onln PEs "⁴ ' cause transfer of the glyeol derivative, the wishing or direction;^{1, 1} benzyl benzoate, away from the sleeping person could, for example at the T " e-di>

^! 5|rvtaUs!. or. its contact with clothing or skin.

b) interface with glyeol; polyslkylene are known oou "

be transcutaneous agents, the benaoat " benzyl is suitable for absorption through the skin of a person... 1 it comes into contact therewith.

c) benzoate and the glycol polyslkylene benzyls, especially 10!; those of high molecular weight, are not very soluble in each other, the j - - nor nor "^{the n} uRs obtaining a solution suitable for aerosol or bath, j is used; two-phase mixtures comprising a cosolvent. Of the j to obtain solutions having the desired degree of viscosity is used cosolvents

volatile YES poses a problem OD optionally inflamma - TDC toxicity

5^ ^! centric during preparation and/or use in aerosols.

d) dilution of 1 'active ingredient means naturally' is^: should appliauer a larger volume the OD. resulting composition for

. the ob + en5vraêrae the acaricidal effect. This is undesirable, because of the increase of the cost involved, and also due to the fact that the compositions have a j 20 tends to make the wet bedding, especially when they are used I ^ ntities · ΐ·ηηΛ℮ρ at 7"

An object of the present invention is to provide compositions acarieides where the evaporation rate benzoate

ii

i-benzyl © is delayed but which avoids the disadvantages mentioned above.

! : - 5f to 50 mainly 10%to 25 weight weight benzoate! the I benzyl mfiis practically insoluble in water at 37 °0. Esters of

The present invention provides a non-- miticidal composition

Aqueous■coprising 4u benzyl benzoate with 5% to 100 %, preferably

'* acids comprise oils suitable flush fixed natural nonvols patterned tiles such status quo 1' todayThe soybean, corn oil and sunflower oil " T-also of other mono -, bis -, and poly-ssthers monomeric alcohols and anhydrides thereof comprising glycerol, sorbitol, sorbitan® T-

; isopropyls alcohol with fatty acids including myrietioue,

$5 isopropyl. The eother fatty acid may be solid or liquid follow the ISS

! even! ticks, TDC oleïquoa linoleic stearic, such as œyristate

exlp ' °rces₀ There can be mentioned as erthors glycerol fatty acid of ' déri votive such that lo ηΐοηορ· - · Imitate, monoatéarie, distearate and oleate.

l \ α

! Il - surprisingly bare the evaporation rate of the benzoate benzyie! either significantly decreased immediately by the presence of amounts

I-j-; relatively small ester of a fatty acid..

I measurement composition may contain other conventional ingredients, 3!! such bare antioxidants and condoms, in amounts commonly understood. ! f

;, Which had been at the beginning that the compositions of the invention rendraiènt bedding wet and would thus lower than the compositions based on glycols th nolyalkylene, whether they were used at the concentrations neeess. for killing the mites. To do it

^: iDs. however not been so. Benzyl benzoate and the esthor fatty acid appear to act ynergétiquement 3, so not requiring less [benzyl benzoate to achieved acarieide given. The garments^: may appear to be slightly smoother after treatment than before, in

the I * 4¹ moisture that gives the cooling of moist objects. Thus, the designed - some circumstances. Hate no absorption or evaporation

the I ' centrations acaricidal benzyl benzoate can be applied without I-jrendre the sheets or other too wet. The present benzyl benzoate:; cannot be truly detected only by a slight odor.

Y₍ Condoms antifungal can be incorporated to reduce or eliminate the i20 fumigattesaspergilius, other known cause of asthma, ; the preferred|hydroxybenzoates, for example hydroxybenzoate of I¹¹butule or benzyl, District Supervisor a concentration of 0.1 % k. 2.0 %, especially 0.5 %■'•by weight. fleci is a high level. The fact that the level of the condom

j25; delayed, generally hydrophobic, this invention makes it even the j'i. surprising in that the activity of such compositions against the j||antifungal must be so high in the glycol benzoate

¹ ■moths woit increased by the retarder rather than decreased.

The compositions of this invention can be made in

; l a form suitable for the application. For aerosol spray, '30 it' composition may, be dissolved in a volatile solvent and comprising a propellant such as■depositing nitride, carbon dioxide, of 1 * hydrecarbone, or fluoroearbone,

i-optionally, RRUs retarder can be mixed with benzyl benzoate and put under uresrion without using a solvent is created by adding

3 $simply a propellant such that the propellant mix dichlorodifluodifluoromethmy or give the vaporization pressure required.

the I

j. optionally, a system - to - 1 brand of direct οη ℮℮ * "the O" ' a réeioi " s|squeeze oeut be used, in which the propellant supplied! lR1 pressure! the SERS physically contacting the ccuposition vaporized. The L? a formulation¹ a developed except aerosol can be performed following methods known T-j as c°tt e converter material.

j-I-optionally, a mixture Group⁵ of. benqyle benzoate and a retarder moves be - DR is on a mattress or - "' Other surface by mechanical means of atomization. , reverse speed. a solution in which bed sheets or other must be quenched, the composition of the invention 1c lueut be dissolved in a volatile solvent, preferably IDA is case

!_V.jtres flammable, for example chloroform or tetrachloromethane.

|; le° soaked sheets may be placed under a stream of hot air.

Optionally, the. sheets may be deceived in a solution the JDE benzyl benzoate and a liquid or solid liquid plus a retarder 19■as the solution obtained is sufficiently fluid to permit imjnersion the fitted sheet, followed by the evaporation of excess solution by being jégou + tert is pressed with compression rollers or other means to provide the required weight jsimilaires solution of benzyl benzoate (per unit area of the sheet,

£0 the compositions of this invention and their solutions, which should be sufficiently flowable to non-aqueous^WITH be applied to be June bedding or other hardware, preferably contain 20 to 90 % benzyl benzoate by weight © essentially, of 1 to 45 % by weight of ester £5Ji in *fatty acid, and 0 to 79 % by weight of a volatile organic solvent. Solutions of the compositions of this invention may be eette." fold-to-uées

Uniformly and to promptly read bedding or other mcmc.i-to-érirux οη· - · a® any suitable method, such as by spraying or P®-R-curling ORR EBU. 3' 1 is ponseillé apply the solution, an EAR excmule C-rlmrlrnge or by spraying, during manufacturing of the material. Treated générélemsnt norΧ ζ ™ 1 ¾ mattress, 30! the? blankets, sheets and goat skins in 1 ·ο vaporize " make it advisable equipment as oou: AuHcomut in uilli? - - cyle URs fortpourcentage retarder solidifying and dispersing all donations. crumb powder suitable such - unterstanding talc or aérosilo (ru-to-5.ro silica). The treatment may be performed on only importing -~mtéviel had?•••sugaralcohols.

35 [are likely to grow or become rervo-to-ôuiro "

the R

The rate of apulicf-activation depends on many. V-naked title of '■■drink "

jLes sheets treated with 0.29 Ξ to 25 g per meter C.® rré OD bensc - benzyl - Te.

the I

rVôs are fatal 1^cyle ■"■ < •■- n-the" was "IOL>" chock of impaired® 25 p/m2

'^ t-benzo © " -' R-R-benzyl ^ the CDRs; * AP n^{the R} the EFI - would provide a ' th the upper I-et - l * q +<- * - X of application of 5 g/m2 to 15 p/ra2 appear to donation ER a compromise^:

|acceptable carrier between the one hand and the cost. other Requlations period 5 RFees. With metcri-to-rOnc thick, such; the covers and the bare peatcî of

|;. goat different amounts of T-applic: ion which may be useful, while bare

; with the mattresses and pillows of O: willwill linuera still other rate,

the j:, the skilled worker will not of HD ' to-ioulté determining best

^{1, 1} rate of benzoatanolicntlon © benzyl © in any circumstance, particular 10, and these levels will be general-to-©nt wm2 of around 50 to the I? / m2.

The nature of the material to be treated does not league account■nouf'ierticn ^ 1. The compositions OD are effective on any textile material used commonly for example cotton, !*■■wool, polyamide and polyester.

15 The II appears to unterstanding mites are killed by the contact ore

¹ ^ hysiciue with benzyl® benzoate liouide or solid, and - not by contact with the steam. It is then preferable to remove at least the larger

_; heap mites before 1' application on the bedding compositions of this ;. present invention. Applying OD OD-benzyl benzoate and © onto bedding rlérlé.ià infested ' 20 a. a small effect, since the nites are capable of causing asthma in both dead unterstanding life,

Follow the preferred method, the mites living or dead are then removed from the bed and bedding material by removing all ICAs objects that

:•' can be removed such as sheets and blankets and easily washed 25¹ in a washing machine completely normal. The pillow is changed preferably for a foam pillow or terylin © to avoid^; dust concentration OD splendid Mito grams within feathers of a pillow VBE1■'■read, the ïiwtoin; ;, and log nearby surfaces are clean " VOCs ν·η its¹ ' iR-*^J ; orR, printing to draw attention partieuliorenont surfaces under

1 corrector the V ' bu + one derivatives do of the m? talc and the seams. this is done both bare ïïnc, either

V - 1 by Joe ···℮ ··· 3, either the piece of sheet YES is located on the mattress is with the content of an aerosol or a vaporizer hr dwarf, or DR is' P-impregnated is placed on the mattress.

Of the TESTA GCIM-to-UEs with OD 1m bedding treated benzoate

35; benzylo gold 'senco of retarder has shown that someone the j-supported very MEN and unterstanding hardware? .' stored characteristics " ITs been effective in preventing're-infoetntioî '. the n? R of dust mites.

I-I-

the I

!

In ^ se^Q illustrated by examples l°s?, in lexcuels Tg 1 IS are expressed in weight "

j is a suitable solution for trerroer © and leak through roller

' compressor for impregnating the fabric hangs-nt and the manufacture:

1 share geleol (mark clistésratemonr - glyceryl)

1 pant of corn oil

10! parts of benzyl benzoate "

Example 2

Suitable solution for a vaporizer using a hand pump such rvcanic unterstanding with A. R." d:

1 geleol from

9 parts of sunflower oil

50 parts of benzyl benzoate.

Aerosol for application on a tissue surface:

OA parts of benzyl benzoate

8 parts by oil " board

25 parts of propellant 12"

_; S at low pressure home vaporizer

. 50 Shares benzyl benzoate

LC myristote|10 shares' isopropyl

74 parts by propellant 114.

'Pure' MB ' Solutiesmpô. ^. ^ ith fufilled. industrial:

1 share myri? isopropyl-Tate

5 parts of benzyl benzoate "

Example 6

Comparison studies have been undertaken on the rate of evapo -

! intake benzyl benzoate,

a) alone

b) in the presence of 20 by weight of glyceryl monostéarte'd® " test .'d '. erappration... ¾ 30 °c zu piecet-volume ventilation

Benzoate

benzyl alone

The benzoate OD

ylbenzyl © + 20 ?• of

manortrente of

"•lyc ' ryle

The ex7 env

debt experiment was made to compare the efficacy of bensoate'd " OCRT^T the L^{the n} the pure® ith two compositions according to the invention yard destruction cbmestioue dust mites.

The compositions tested, were 9.ï

A pure benzyl benzoate and Qn

10 B shares benzyls OD benzoate

2 glyceryl monodistéamte shares

0. 10 against high bensyle benzoate

7 shares of isopropylsrayristate

Tests were conducted with a moth dermatophogoïdesfarinas<from - the I ' a laboratory colony, mites were preserved meat dog comminuted and under the best conditions to 25° g and relative humidity © 80 D. %. The techniques described non-HellerHoupt and Busrine (j pieces. The MED " rats. 1974, 11? 551552). The three compositions were, tested at 8 different levels. ^ enreyist has greatly accelerated mortality Cures * exposing? 4 hours, Leo mortalities were compared to di "willwill ffra" iin0S standard and analyzed with a computer the LOS GDLs - 7600

experience! States obtained were the suivantr;

Ppthe mthe Posît^- ' o-n-adsl " has (flush / ^ BJECTIVES from adipocytesredetermination. average η: n-℮ρ Η.rR-D.monosaccharide 260 I-30,261

B. 217" 20,225

Grams of O/O T of OJ 2 °3.

L-<=digit VLD 99? 9 is ^ ^ - ΐο ν a cough death - '¹lté of 99"^Q ■">specific conditions: - pleat: * I-cipher is small, more 1 - composition thereof. " gold + eliç, it I^{the R,} t-frat swans of ^ - CIRs ηκ compositions B and G feels all 1st two more lethal " ou the b * ^ willwill rront of. pure besæyle? H or © each contains only EEP r3 -^F. of the R/H ^ baasoete ' yl.