COMPOSITION CONTAINING CHLOROGENIC ACID FOR PREVENTING OR TREATING GASTROESOPHAGEAL REFLUX DISEASE

09-08-2012 дата публикации
Номер:
WO2012105798A2
Принадлежит: 성균관대학교 산학협력단
Контакты:
Номер заявки: KR07-00-201246
Дата заявки: 31-01-2012



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The present invention relates to a pharmaceutical composition for preventing or treating gastroesophageal reflux disease and to a food composition for preventing or treating gastroesophageal flux disease, which contain chlorogenic acid, the pharmaceutically acceptable salts thereof, or derivatives thereof. The present invention also relates to a method for preventing or treating gastroesophageal reflux disease comprising a step of administrating said pharmaceutical composition to an entity, and to the use of chlorogenic acid, the pharmaceutically acceptable salts thereof, or derivatives thereof. According to the present invention, chlorogenic acid, the pharmaceutically acceptable salts thereof, or derivatives thereof may reduce the area of lesions in the esophagus caused by the reflux of the contents of the stomach or duodenum to the esophagus, without changing the pH level in the stomach, and may reduce histological changes of inflammatory cells, and therefore may be valuably used in preventing or treating gastroesophageal reflux disease with no side effects.

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