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Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Применить Всего найдено 27. Отображено 27.
20-02-2003 дата публикации

Fusion polypeptides of human serum albumin and a therapeutically active polypeptide

Номер: US20030036172A1
Принадлежит: Aventis Behring L.L.C.

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

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24-01-2006 дата публикации

Methods of treatment with erythropoietin and albumin fusion protein

Номер: US0006989365B2

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

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06-06-2006 дата публикации

Hormone and albumin fusion protein

Номер: US0007056701B2

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

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22-08-2006 дата публикации

Insulin and albumin fusion protein

Номер: US0007094577B2

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

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27-10-2005 дата публикации

Fusion polypeptides of human serum albumin and a therapeutically active polypeptide

Номер: US20050239167A1
Принадлежит: Aventis Behring L.L.C.

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

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06-05-2004 дата публикации

Fusion polypeptides of human serum albumin and a therapeutically active polypeptide

Номер: US20040086976A1
Принадлежит: Aventis Behring L.L.C.

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

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16-05-2000 дата публикации

Preparation of factor IX

Номер: US0006063909A1
Принадлежит: Aventis Behring L.L.C.

A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IXa, and/or degraded factor IX peptides. The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.

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12-03-2008 дата публикации

THERAPEUTIC FRAGMENTS OF VON WILLEBRAND FACTOR

Номер: EP0000833659B1
Принадлежит: Aventis Behring L.L.C.

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18-05-2006 дата публикации

Fusion polypeptides of human serum albumin and a therapeutically active polypeptide

Номер: US20060105429A1
Принадлежит: Aventis Behring L.L.C.

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

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01-05-2003 дата публикации

Fusion polypeptides of human serum albumin and a therapeutically active polypeptide

Номер: US20030082747A1
Принадлежит: Aventis Behring L.L.C.

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

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06-12-2005 дата публикации

Interferon and albumin fusion protein

Номер: US0006972322B2

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

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09-05-2006 дата публикации

G-CSF and albumin fusion protein

Номер: US0007041478B2

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

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28-03-2000 дата публикации

Preparation of factor IX

Номер: US0006043215A1
Принадлежит: Aventis Behring L.L.C.

A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IXa, and/or degraded factor IX peptides. The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.

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17-01-2006 дата публикации

Erythropoietin and albumin fusion protein, nucleic acids, and methods thereof

Номер: US0006987006B2

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

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03-02-2004 дата публикации

Fusion polypeptides of human serum albumin and a therapeutically active polypeptide

Номер: US0006686179B2

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

Подробнее
20-02-2003 дата публикации

Fusion polypeptides of human serum albumin and a therapeutically active polypeptide

Номер: US20030036171A1
Принадлежит: Aventis Behring L.L.C.

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

Подробнее
25-07-2006 дата публикации

Interleukin and albumin fusion protein

Номер: US0007081354B2

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

Подробнее
30-01-2003 дата публикации

Fusion polypeptides of human serum albumin and a therapeutically active polypeptide

Номер: US20030022308A1
Принадлежит: Aventis Behring L.L.C.

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

Подробнее
20-02-2003 дата публикации

Fusion polypeptides of human serum albumin and a therapeutically active polypeptide

Номер: US20030036170A1
Принадлежит: Aventis Behring L.L.C.

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

Подробнее
06-05-2004 дата публикации

Fusion polypeptides of human serum albumin and a therapeutically active polypeptide

Номер: US20040086977A1
Принадлежит: Aventis Behring L.L.C.

Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.

Подробнее
02-09-1992 дата публикации

Preparation of factor ix

Номер: CA2105282A1

A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IX a, and/or degraded Factor IX peptides. The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.

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29-05-1997 дата публикации

Therapeutic fragments of von willebrand factor

Номер: CA2223702A1

Processes for preparing aqueous solutions of cysteine--altered von Willebrand Factor fragment which are substantially free of aggregate and capable of therapeutic use for treating thrombosis are provided. The claimed process comprises providing an aqueous solution of vWF fragment and denaturant and containing undesired contaminants, said solution having an acidic pH; separating said contaminants from said solution by contacting said solution with an affinity chromatography medium to which said vWF fragments adhere; eluting said vWF fragment from said affinity chromatography medium in the presence of the denaturant; and separating the eluted fragment from said denaturant while maintaining the aqueous solution of the fragment at a pH of about 2.5 to less than about 5.5 to increase monomerization of, and decrease aggregation of, said fragment, thereby forming an aqueous solution of vWF fragment which is substantially free of aggregate.

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07-01-1993 дата публикации

Therapeutic fragments of von willebrand factor

Номер: CA2110585A1

An aqueous solution of cysteine-altered von Willebrand Factor fragment which is substantially free of aggregate and capable of therapeutic use for treating thrombosis and a process for preparing such a solution comprising: (A) providing an aqueous solution of the fragment and denaturant; (13) purifying the solution of fragment and denaturant under conditions which promote conversion of aggregated forms of the fragment to the dimeric and/or monomeric forms thereof to provide purified fragment; (C) separating the dissolved; purified fragment from the denaturant while maintaining the aqueous solution of the fragment at a pH of about 2.5 to less than about 5.5 to increase monomerization of, and decrease aggregation of, said purified fragment, thereby forming an aqueous solution of fragment which is substantially free of aggregate.

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05-08-1993 дата публикации

Human serum-albumin, preparation and use thereof

Номер: CA2126356A1

2126356 9315204 PCTABS00163 La présente invention concerne une préparation de sérum-albumine humaine ayant un indice de colorimétrie inférieur à 0,2, résultant de l'expression, dans un hôte eucaryote ou procaryote, d'une séquence d'ADN exogène. The present invention relates to a preparation of human serum albumin having a colorimetric index less than 0.2, resulting from the expression, in a eukaryotic or prokaryotic host, of an exogenous DNA sequence.

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15-03-2008 дата публикации

THERAPEUTISCHE FRAGMENTE DES ßVON WILLEBRANDß FAKTORS

Номер: ATE388722T1
Принадлежит: Aventis Behring L L C

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