Preparation of factor IX

A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IXa, and/or degraded factor IX peptides. The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.

Preparation of pasteurized human plasminogen

This invention relates to a method for producing a plasminogen preparation which has been pasteurized to produce a hepatitis safe injectable plasminogen. The method comprises: adding to an aqueous solution of plasminogen the protective agent of methyl lysine ester, or ethyl lysine ester or a hydrochloride salt thereof which has antifibrinolytic acitivity to thereby attach the agent to plasminogen and form a modified plasminogen; and subjecting the resulting modified agent to a heat treatment of at least 60° C. for at least 10 hours. Further, the protective agent may be separated from the modified plasminogen by affinity chromatography.

Preparation of factor IX

A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IXa, and/or degraded factor IX peptides. The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.

Multi-functional exercising device

A multi-functional exercising machine includes a main structure, a jogging device, a rowing device, a stationary bicycle, a pulling spring, a shelf, a stand, a chair, and a pull-up bar. The stand is attached to the main structure while standing on the jogging device. The chair or the pull-up bar is attachable to the stand.

Method of providing power to an integrated circuit

A CMOS integrated circuit assembly for providing reduced power supply and ground inductances has a first conducting layer which is formed over an insulating layer formed on top of the integrated-circuit chip. The first conducting layer is connected to wire bond pads which are wirebonded to a package. This first conducting layer forms a single, low-inductance conductor for a VDD supply voltage and extends over a substantial area so that it has an inductance significantly less than the inductance of a conventional conductor. A second conducting layer is forms a low-inductance VSS conductor. Power can be selectively distributed through conductive layers of this to provide power supply isolation between selected circuits of the integrated circuit.

Preparation of factor ix

A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IX a, and/or degraded Factor IX peptides. The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.

Preparation of factor ix

A novel method of protecting blood coagulation factor IX from proteases during purification or storage is disclosed. High concentrations of one or more water soluble organic or inorganic salts are used to stabilize factor IX, contained within blood plasma-derived solutions, or contained within solutions derived from other sources, against conversion to clinically unacceptable peptide structures such as factor IX a, and/or degraded Factor IX peptides. The technique is useful in stabilizing intermediate purity factor IX preparations during purification, and in maintaining the integrity of purified factor IX during long term storage. Stable high specific activity factor IX preparations are also disclosed.

Improvement in a process to purify and preserve factor IX derived from human blood plasma or other source, processes for the preparation of a therapeutic composition, and to stabilize factor IX, partially purified aqueous factor IX solution, therapeutic composition and process to treat disease christmas

Herstellung von faktor-ix

Esterový polymér, polymérna lubrikačná kompozícia

Ester polymer, polymeric lubricating composition containing said polymer and its use

Polyesterová pryskyřice a její pouľití pro lubrikaci skleněných vláken

Polyesterov prysky°ice, kter m molekulovou hmotnost v t ne 1000, p°i em obsahuje adukt Michaelovy adice vytvo°en² reakc aminoalkylalkoxysilanu obecn ho vzorce (I), ve kter m R.sup.O.n. znamen alkylovou skupinu, kterou je methylov , ethylov , propylov nebo butylov skupina, arylovou skupinu, kterou je fenylov , naftylov nebo tolylov skupina nebo benzylovou skupinu, R.sup.1.n. a R.sup.2.n. mohou b²t stejn nebo rozd ln , p°i em znamenaj atom vod ku, alkylovou skupinu, kterou je methylov , ethylov nebo propylov skupina nebo benzylovou skupinu, X znamen hydrolyzovatelnou skupinu, y je 0 nebo 1, v je cel slo od 2 do 6, w je cel slo od 2 do 6, z je 0, 1 nebo 2, a konjugovan ethylenicky nenasycen polyesterov prysky°ice obsahuj c segment polyalkylenglykolov ho °et zce, p°i em polyesterov prysky°ice byla silylov na pr m rn alespo 0,5 molem a maxim ln p ti moly aminoalkylalkoxysilanu na mol polyesterov prysky°ice. Pou it t to polyesterov prysky°ice pro lubrikac\