18-12-2014 дата публикации
Номер: US20140370101A1
This invention relates to a 2,2′,6,6′-tetraisopropyl-4,4′-biphenol lipid microsphere preparation having 2,2′,6,6′-tetraisopropyl-4,4′-biphenol as its active ingredient and formed into said lipid microsphere preparation with common medically used injection-grade oil, emulsifier, and injection-grade water. 110-. (canceled)11. A 2 ,2′ ,6 ,6′-tetraisopropyl-4 ,4′-biphenol lipid microsphere preparation for use in intravenous injections , wherein every 100 ml of said preparation comprises 0.1 to 0.3 weight % of 2 ,2′ ,6 ,6′-tetraisopropyl-4 ,4′-biphenol , 10 to 30 weight % of soybean oil , 1 to 1.5 weight % of injection-grade egg lecithin , 0.5 to 1 weight % of vitamin E , 0.01 to 1 weight % of sodium hydroxide , 0.1 to 2.5 weight % of glycerin , 0.01 to 1 weight % of EDTA , and the remaining being injection-grade water; and wherein the average particle size is 150 nm to 300 nm.121. A method for preparing the 2 ,2′ ,6 ,6′-tetraisopropyl-4 ,4′-biphenol lipid microsphere preparation of claim for use in intravenous injections , comprising the steps of:1) Dissolving appropriate amounts of injection-grade egg lecithin and vitamin E completely in injection-grade soybean oil under a nitrogen atmosphere in a 70° C. water bath before adding 2,2′,6,6′-tetraisopropyl-4,4′-biphenol, with heat and stirring for dissolution, to obtain an oil phase;2) Dissolving appropriate amounts of glycerin and EDTA in injection-grade water, with stirring, to obtain an aqueous phase;3) Adding said oil phase slowly to said aqueous phase while shearing under nitrogen at 10000 r for 5 minutes to obtain a preliminary emulsion, and adjusting the pH to around 8.0 with NaOH; and4) Homogenizing said preliminary emulsion 5 to 8 times under a pressure of 800 to 900 bar before filtering with a microporous membrane filter, flushing with nitrogen, sealing and autoclaving at 115° C. to obtain said lipid microsphere preparation. This invention relates to 2,2′,6,6′-tetraisopropyl-4,4′-biphenol lipid microsphere ...
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