21-03-2019 дата публикации
Номер: US20190083443A1
Принадлежит:
Provided in the present invention are ingenol compounds and a use thereof in preparing an anti-HIV latency drug. In particular, provided in the present invention is a use of ingenol compounds and pharmaceutically acceptable salts thereof for preparing a drug for: (a) intervening with HIV viral latency; (b) activating an HIV virus that has been integrated into mammalian genomes; and/or (c) inducing the expression of the dormant HIV provirus in infected cells. The compounds of the present invention may also be used in combination with antiretroviral drugs to accelerate the removal of latent viral reservoirs. 1. (canceled)69.-. (canceled)11. The method of claim 5 , wherein the method further comprises the step of activating a latent HIV virus.12. The method of claim 5 , wherein the method further comprises the step of inhibiting and/or killing a latent HIV virus. The present invention relates to the field of the medicine, in particular, to ingenol compounds and use thereof in anti-HIV latency treatment.Acquired immunodeficiency syndrome (AIDS) is a contagious disease that seriously endangers people's life and health caused by HIV infection. According to WHO statistics, there are more than 40 million AIDS patients worldwide, with 5 million new patients each year, while about 3 million deaths each year. At present, the main clinical treatment of AIDS is Highly active antiretroviral therapy (HAART), which not only effectively controls HIV replication, but also rebuilds the immune function of AIDS patients, thereby opening the door of hope for the treatment of AIDS. People have hoped that HAART can completely eliminate HIV in vivo, thereby achieving the goal of completely curing AIDS. However, subsequent practice has shown that although HAART can inhibit viral replication in patients at the largest extent, and reduce plasma viral load to levels not detected by conventional detection methods, there are still viruses in the infected body. Once drug treatment is stopped, the ...
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