19-04-2018 дата публикации
Номер: US20180104200A1
Принадлежит:
The present invention provides topical dosages and formulations of lidocaine and pharmaceutically acceptable salts thereof, which are efficacious, chemically stable and physiologically balanced for safety and efficacy, particularly for debridement pain, and increase the duration of pain relief, and thereby provide more effective treatment to chronic open wounds, particularly those in non-mucosal tissue. 1) A method of treating pain comprising applying to an open wound a topical dosage form comprising from 2 to 5% lidocaine , wherein said dosage form releases less than 75% of its lidocaine at 30 minutes and less than 90% of its lidocaine at 60 minutes when tested in a USP Apparatus 1 (paddle) at 50 rpm in 500 ml of an acetic acid/sodium acetate buffer , pH 4.0 at 32° C.2) A method of treating pain in a chronic open wound in non-mucosal tissue in a patient in need thereof , comprising:a) debriding the chronic open wound; i) from 70 to 90 weight parts of water or a mixture of water and a humectant selected from glycerine, glycerol, polyethylene glycol, and combinations thereof;', [{'br': None, 'sub': 2', '2', 'a', '2', '3', 'b', '2', '2', 'a, 'HO—[CH—CH—O]—[CH—CH(CH)—O]—[CH—CH—O]—H'}, 'wherein the ratio of a:b is from 2:1 to 4:1, and the molecular weight of said copolymer is from 9000 to 16000;, 'ii) from 10 to 25 weight parts of a copolymer having the following block structure, 'iii) from 0.1 to 3.0 weight parts of xanthan gum; and', 'iv) from 2.0 to 5.0 weight parts of an anesthetic;, 'b) topically applying to the chronic open wound an ointment or gel comprisingc) applying an occlusive bandage to the chronic open wound;d) removing the occlusive bandage from the chronic open wound; ande) debriding the chronic open wound.3) A method of treating pain in a chronic open wound in non-mucosal tissue , comprising: i) from 70 to 90 weight parts of water or a mixture of water and a humectant selected from glycerine, glycerol, polyethylene glycol, and combinations thereof;', ...
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