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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 3947. Отображено 100.

12-01-2012 дата публикации

Energy based devices and methods for treatment of patent foramen ovale

Номер: US20120010608A1

Автор: Dan Francis, Hanson S. Gifford, Iii, Jose Alejandro, Kenneth Horne, Mark E. Deem, William Malecki

Принадлежит: Terumo Corp

Methods and apparatus for treatment of patent foramen ovale (PFO) provide for applying energy to tissues adjacent the PFO with a catheter device to substantially close the PFO acutely. Apparatus generally includes a catheter device having at least one energy transmission member at or near its distal end configured to apply energy to PFO tissues to acutely, substantially close the PFO. Applied energy may be monopolar or bipolar radiofrequency energy or any other suitable energy, such as laser, microwave, ultrasound, resistive heating or the like. Some embodiments of a catheter device fuirther include one or more tissue apposition members near the distal end for helping bring PFO tissues together, such as a PFO covering member, a vacuum applying member and/or the like. PFO closure via energy-based approaches of the invention may help prevent stroke, treat migraine headache, and possibly treat or prevent other medical conditions.

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Номер записи: 1

22-03-2012 дата публикации

Tissue ablation with irreversible electroporation

Номер: US20120071874A1

Автор: Boris Rubinsky, Rafael Davalos

Принадлежит: UNIVERSITY OF CALIFORNIA

A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable.

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Номер записи: 2

03-05-2012 дата публикации

High-frequency electroporation for cancer therapy

Номер: US20120109122A1

Автор: Christopher B. ARENA, Michael B. Sano, Rafael V. Davalos

Принадлежит: Virginia Polytechnic Institute and State University

The present invention relates to the field of biomedical engineering and medical treatment of diseases and disorders. Methods, devices, and systems for in vivo treatment of cell proliferative disorders are provided. In embodiments, the methods comprise the delivery of high-frequency bursts of bipolar pulses to achieve the desired modality of cell death. More specifically, embodiments of the invention relate to a device and method for destroying aberrant cells, including tumor tissues, using high-frequency, bipolar electrical pulses having a burst width on the order of microseconds and duration of single polarity on the microsecond to nanosecond scale. In embodiments, the methods rely on conventional electroporation with adjuvant drugs or irreversible electroporation to cause cell death in treated tumors. The invention can be used to treat solid tumors, such as brain tumors.

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Номер записи: 3

30-08-2012 дата публикации

Electrical ablation devices and methods

Номер: US20120221002A1

Автор: David N. Plescia, Gary L. Long, Gregory J. Bakos

Принадлежит: Ethicon Endo Surgery Inc

An ablation apparatus may generally comprise an elongated body having a proximal end and a distal end and a non-conductive tip at the distal end, a conductive sheath at least partially surrounding a portion of the elongated body intermediate the proximal end and the tip, and an electrical conductor electrically connected to the conductive sheath. The ablation apparatus may comprise a first electrode having a first diameter and a plurality of second electrodes each having a second diameter, wherein the first diameter is greater than the second diameter. Methods of using the ablation apparatus are also described.

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Номер записи: 4

04-10-2012 дата публикации

Reducing risk of complications associated with tissue ablation

Номер: US20120253188A1

Автор: George A. HOLLAND

Принадлежит: UNIVERSITY OF ROCHESTER

Methods and systems are described that reduce risks of hematologic, metabolic, and renal complications in a mammal, such as a human, undergoing tissue ablation. One such method includes inserting a probe into a mammal and ablating abnormal tissue in the mammal by emitting a first amount of energy from the probe. In some embodiments, after emitting the first amount of energy, a method can include denaturing proteins released from cells in the abnormal tissue by emitting a second amount of energy from at least one of the first probe or a second probe inserted into the mammal. Furthermore, some embodiments can be implemented such that during or after the emitting the energy from a probe, a composition is administered to the mammal in an effective amount to denature proteins released from cells in the abnormal tissue.

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Номер записи: 5

04-10-2012 дата публикации

Surgical Devices And Methods of Use Thereof

Номер: US20120253343A1

Автор: Brian M. Conley, Michael E. McClurken, Roger D. Greeley

Принадлежит: MEDTRONIC ADVANCED ENERGY LLC

The invention provides surgical devices and methods to treat tissue. In one device embodiment, the invention comprises a bipolar electrosurgical device to treat tissue in a presence of radio frequency power and a fluid provided simultaneously from a distal portion of the device, with the device comprising a disc shaped distal end. In one method embodiment, the invention comprises a method of treating tissue having a blood vessel during spine surgery, with the method comprising pressing a portion of the blood vessel against a supporting spine structure with a surgical device to provide a compressed portion of the blood vessel, and heating the compressed portion of the blood vessel with the surgical device sufficiently to inhibit a blood flow through the vessel after the surgical device is removed from the blood vessel.

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Номер записи: 6

22-11-2012 дата публикации

Device for non-thermal, electrically-induced closure of blood vessels by occlusion

Номер: US20120296330A1

Автор: Alexander B. Vankov, Daniel V. Palanker

Принадлежит: Leland Stanford Junior University

Devices for the non-thermal, electrically-induced temporary or permanent closure of blood vessels. The subject devices employ pulsed electrical energy according to a defined regime to effect controlled occlusion of targeted blood vessels without hating the vessel and with minimal damage to adjacent tissue. The extent of vessel closure, i.e., temporary (vasoconstriction) or permanent (thrombosis), is controlled based on the manipulation of various parameters of the electrical stimulation regime as well as the configuration of the electrodes used to apply the regime.

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Номер записи: 7

31-01-2013 дата публикации

Intracardiac tools and methods for delivery of electroporation therapies

Номер: US20130030430A1

Автор: Jordon D. Honeck, Mark T. Stewart

Принадлежит: MEDTRONIC ABLATION FRONTIERS LLC

A medical system, including a medical device having a plurality of deployable arms, and at least one electrode on at least one of the plurality of arms; and an electric signal generator in communication with the medical device, the electric signal generator programmed to deliver pulsed energy to the medical device sufficient to induce irreversible electroporation ablation.

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Номер записи: 8

14-02-2013 дата публикации

Drive mechanism for articulation of a surgical instrument

Номер: US20130041403A1

Автор: Eric Jones, James S. Cunningham, Marc Spinali

Принадлежит: COVIDIEN LP

A surgical instrument includes a housing, an end effector and an elongated shaft extending therebetween. The elongated shaft includes a distal portion that is movable between aligned and articulated configurations. A pair of drive cables extends through the elongated shaft and is coupled to the distal portion such that reciprocal longitudinal motion of the drive cables induces movement of the distal portion between the aligned and articulated configurations. An articulation drive mechanism is operable to induce reciprocal longitudinal motion of the drive cables. The drive mechanism includes an actuator and a pair of torsion members that are rotatable about two distinct axes in response to movement of the actuator. A respective follower is operatively coupled to each torsion member to translate in a respective longitudinal direction in response to rotation of the torsion members, and each follower is coupled to a respective drive cable to impart translational motion thereto.

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Номер записи: 9

28-02-2013 дата публикации

Surgical cutting and fastening device with descendible second trigger arrangement

Номер: US20130053831A1

Автор: Foster B. Stulen, Gregory W. Johnson, Jason L. Harris, Jeffrey S. Swayze, Prasanna Malaviya

Принадлежит: Ethicon Endo Surgery Inc

A nested trigger assembly for a surgical instrument may generally comprise a first trigger and a second trigger, wherein the first trigger and the second trigger are movable together on a first stroke of the nested trigger assembly, wherein the second trigger is configured to be biased away from the first trigger after the first stroke and before a second stroke, and wherein the second trigger is configured to be moved toward to the first trigger during the second stroke. A surgical instrument may generally comprise a shaft comprising a proximal end and a distal end, a handle extending from the proximal end, wherein the handle comprises a gripping portion, and a nested trigger assembly extending from the handle. The nested trigger assemble may comprise one of a separable trigger assembly and a divisible trigger assembly.

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Номер записи: 10

02-05-2013 дата публикации

Cryogenic balloon device with radiofrequency tip

Номер: US20130110098A1

Автор: Jean-Pierre Lalonde

Принадлежит: MEDTRONIC CRYOCATH LP

An intravascular ablation device, including a flexible elongate body; an expandable element positioned on the elongate body; a radiofrequency or electroporation treatment segment located distally of the expandable element; a cryogenic coolant source in fluid communication with an interior of the expandable element; and a radiofrequency or electroporation energy source in communication with the radiofrequency or electroporation treatment segment.

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Номер записи: 11

30-05-2013 дата публикации

Electrosurgical radio frequency energy transmission medium

Номер: US20130138098A1

Автор: James H. Orszulak

Принадлежит: Covidien AG

A system and method for transmitting electrosurgical energy from a generator to an electrosurgical instrument are provided. The electrosurgical system includes a generator adapted to generate electrosurgical energy for treating tissue. The generator includes one or more active output terminals which supply energy to the tissue. The active output terminals are operatively connected to one or more supply lines. The generator also includes one or more return output terminal which returns energy from the tissue. The return output terminals are operatively connected to at least one return line. The system also includes an electrosurgical instrument operatively connected to the one or more supply lines and one or more return electrodes operatively connected to one or more return lines. The system further includes an electrosurgical cable including one or more supply lines and one or more return lines. The one or more supply lines and one or more return lines are wound in a double helix fashion such that the electrical field along the cable is mitigated along the length thereof.

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Номер записи: 12

07-11-2013 дата публикации

Inductively heated multi-mode surgical tool

Номер: US20130296838A1

Автор: David McNally, Kim Manwaring

Принадлежит: Domain Surgical Inc

Thermal, Electrosurgical and Mechanical modalities may be combined in a surgical tool. Potentially damaging effects in a first modality may be minimized by using a secondary modality. In one example, thermal hemostasis may thus help electrosurgical applications avoid the adverse tissue effects associated with hemostatic monopolar electrosurgical waveforms while retaining the benefits of using incising waveforms.

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Номер записи: 13

19-12-2013 дата публикации

Rf sealing instrument

Номер: US20130338660A1

Автор: Christoph Rothweiler, Patrick Heizmann

Принадлежит: Aesculap AG

A bipolar RF sealing instrument includes two instrument branches which are movable relative to one another at least to an open and a closed position, and an instrument handle with two handle units, each associated with a respective instrument branch and coupled for manually operating the instrument branches and for applying to the instrument branches a predetermined closing force at the closed position, a first of the two instrument branches having a terminal for an external RF generator and the second instrument branch adapted to be electrically coupled via an instrument-internal power contact with the first instrument branch. The power contact may be a spring contact for contact closure at a closure position. In addition or alternatively, an instrument-internal control switch is present and only activated when the predetermined closing force is reached, to enable the supply of electric current from an external RF generator to the instrument branch(es).

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Номер записи: 14

02-01-2014 дата публикации

Surgical end effector jaw and electrode configurations

Номер: US20140005640A1

Автор: Chester O. Baxter, III, David C. Yates, Frederick E. Shelton, IV, Jerome R. Morgan

Принадлежит: Ethicon Endo Surgery Inc

A surgical end effector may comprise first and second jaw members. The second jaw member may comprise an offset proximal supply electrode that is positioned to contact an opposing member of the first jaw member when the first and second jaw members are in the closed position. The second jaw member may also comprise a distal supply electrode that is positioned distal of the offset proximal electrode and is aligned with a conductive surface of the first jaw member when the first and second jaw members are in the closed position. When the first and second jaw members are in the closed position, the proximal supply electrode may be in contact with the opposing member and the distal supply electrode is not in contact with the conductive surface of the first jaw member.

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Номер записи: 15

09-01-2014 дата публикации

Apparatus and method for gastric bypass surgery

Номер: US20140012248A1

Автор: Robert L. Wilcox, Stefan Josef Matthias Kraemer, Thomas James Clement

Принадлежит: Individual

A medical treatment device includes an elongate member having an internal volume, a proximal end, and a distal end, the internal volume extending from the proximal end to the distal end. The medical treatment device further includes a first coupler and a second coupler, the first coupler and the second coupler coupled to the internal volume of the elongate member; a first joining member and a second joining member, the first joining member coupled to the first coupler and the second joining member coupled to the second coupler. The first joining member is configured to attach to a first biological matter location, and the second joining member is configured to attach to a second biological matter location, the second location being distal to the first location. The second coupler is configured for manipulation to align relative the first coupler such that the second biological matter location relocates adjacent the first biological matter location. The first joining member and the second joining member are configured to join the first biological matter location to the second biological matter location.

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Номер записи: 16

23-01-2014 дата публикации

Medical system and method of use

Номер: US20140025057A1

Автор: John H. Shadduck, Michael Hoey

Принадлежит: Tsunami MedTech LLC

An instrument and method for applying thermal energy to targeted tissue. An instrument and method for tissue thermotherapy. In one embodiment, a method includes providing a vapor source comprising a pump configured for providing a flow of liquid media from a liquid media source into a vaporization chamber having a heating mechanism, actuating the pump to provide the liquid into the vaporization chamber, applying energy from the heating mechanism to convert a substantially water liquid media into a minimum water vapor level for causing an intended effect in tissue. For examples such levels can comprise at least 60% water vapor, at least 70% water vapor, at least 80% water vapor or at least 90% water vapor for causing an intended effect in tissue.

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Номер записи: 17

20-02-2014 дата публикации

Methods for promoting wound healing

Номер: US20140052216A1

Автор: David N. Plescia, Gary L. Long, Gregory J. Bakos, Peter K. Shires

Принадлежит: Ethicon Endo Surgery Inc

A method for promoting wound healing at a wound site includes subjecting the wound site to electrical pulses to promote wound healing during at least one of the stages of wound healing. The method may further include closing the wound site by sutures or staples prior to and or after applying the electrical pulses that promote wound healing.

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Номер записи: 18

20-03-2014 дата публикации

Methods and apparatus for renal neuromodulation

Номер: US20140081259A1

Автор: Denise Zarins, Douglas Sutton, Erik Thai, Hanson Gifford, III, Howard R. Levin, Mark E. Deem, Mark Gelfand

Принадлежит: Medtronic Ardian Luxembourg SARL

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

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Номер записи: 19

07-01-2016 дата публикации

ELECTROSURGICAL SYSTEM

Номер: US20160000495A1

Автор: Albrecht Jeremy, Durant Dan, Elliott Patrick, Gorin Igor, Hudson Kevin, Jacobs Hank, JOHNSON GARY, Kowalski Jerry, Linville-Engler Benjamin, LOGAN Michael, Matthews Thomas, McFarland Daniel, Nguyen Duy, Sabarad Jagdish, Tiberia Lou, Whitlock Michael

Принадлежит:

An electrosurgical generator arranged to supply radio frequency (RF) energy to fuse tissue is provided. The generator is arranged to supply RF energy through a removably coupled electrosurgical instrument to fuse tissue grasped by the instrument. The generator monitors a phase angle of the supplied RF energy and adjusts or terminates the supplied RF energy based on the monitored phase angle in comparison to predetermined thresholds and conditions to optimally fuse the tissue. The electrosurgical instrument conducts radio frequency energy to fuse tissue captured between the jaws and a blade to mechanically cut tissue between the jaws. A conductive post positioned on the jaw adjacent to the blade 1. An electrosurgical system comprising:an electrosurgical instrument arranged to grasp and fuse tissue using radio frequency (RF) energy; andan electrosurgical generator connectable to the electrosurgical instrument and configured to supply the RF energy through the electrosurgical instrument, the generator comprising:an RF amplifier to supply RF energy through the electrosurgical instrument; anda controller arranged to monitor a phase angle of the supplied RF energy, the controller signaling the RF amplifier to adjust voltage of the supplied RF energy when the monitored phase angle is equal to a predefined phase value or starts decreasing.2. The system of wherein the predefined phase value is zero degrees.3. The system of wherein the adjustment of voltage by the RF amplifier comprises the RF amplifier decreasing the voltage of the supplied RF energy.4. The system of wherein the adjustment of voltage by the RF amplifier comprises the RF amplifier maintaining the voltage of the supplied RF energy at its current voltage level.5. The system of wherein the adjustment of voltage by the RF amplifier comprises the RF amplifier setting the voltage of the supplied RF energy to a predetermined voltage.6. The system of wherein the controller determines a second predefined phase value ...

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Номер записи: 20

07-01-2021 дата публикации

System, method and computer-accessible medium for in-vivo tissue ablation and/or damage

Номер: US20210000527A1

Автор: Govindarajan Srimathveeravalli, Stephen Barnett SOLOMON

Принадлежит: Memorial Sloan Kettering Cancer Center

Systems, methods and computer-accessible mediums can be provided that can establish particular parameters for electric pulses based on a characteristic(s) of the tissue(s), and control an application of the electric pulses to tissue(s) for a plurality of automatically controlled and separated time periods to ablate the tissue(s) through mediation of membrane potential and through inducing the cells through a plurality of charge-discharge cycles such that an electroporation of a majority of the tissue(s) is prevented or reduced.

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Номер записи: 21

11-01-2018 дата публикации

ENDOVASCULAR PLASMA TREATMENT DEVICE AND METHOD OF USE

Номер: US20180008335A1

Автор: Delaney Kevin L.

Принадлежит: ANGIODYNAMICS, INC.

A device and method for treating a hollow anatomical structure using matter in a plasma state. Device includes a tubular delivery device comprising a tubular body, a hub, and a distal end, wherein the tubular body device having a longitudinal fluid delivery channel and an exit port near the distal end. Device also contains a container having pre-plasma matter being operatively coupled to the hub, at least one energy-emitting element operatively coupled near the distal end of the tubular delivery device. The energy-emitting element is operatively connected to energy source. 1. An endoluminal treatment system comprising:a container, the container being filled with pre-plasma material;an energy source; and a proximal end and a distal end;', 'a hub situated at the proximal end, the hub connected to the container; and', 'at least one energy emitting element near the distal end of the catheter and a catheter lumen, the at least one energy emitting element connected to the energy source., 'a catheter comprising2. The system of claim 1 , wherein plasma is created from pre-plasma matter by activating the energy emitting element.3. The system of claim 2 , wherein the pre-plasma is in a fluid state.4. The system of claim 3 , wherein the pre-plasma comprises a saline.5. The system of claim 1 , wherein the at least one energy emitting element comprises a radiofrequency electrode.6. The system of claim 1 , wherein the at least one energy emitting element comprises an electroporation electrode.7. The system of claim 1 , wherein the at least one energy emitting element comprises a microwave antenna.8. The system of claim 2 , wherein the plasma comprises low-level thermal plasma.9. An endoluminal treatment system comprising:an energy source;a container, the container being filled with pre-plasma material and having at least one energy emitting element, the at least one energy emitting element connected to the energy source; and a proximal end and a distal end;', 'a fluid delivery ...

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Номер записи: 22

10-01-2019 дата публикации

Low Power Tissue Sealing Device and Method

Номер: US20190008576A1

Автор: Helfer Joel, Kennedy Jenifer, Ross David, Schechter David, Schmaltz Dale

Принадлежит:

An electrosurgical instrument has a power supply operatively coupled to an end effector. The end effector has a pair of jaws for effectuating an action on tissue positioned therebetween. The power supply is configured to input a first signal and a second signal to a buck-boost converter. The buck-boost converter is configured to transmit an output to an H-bridge circuit. The H-bridge circuit is configured to pass a signal to a resonant LC transformer circuit. The power supply is configured to transmit a power signal. The pair of jaws are operatively coupled to the power supply to receive the power signal, the power having no more than 80 Volts RMS, and less than 2 Amps RMS. The power is configured to seal the tissue positioned between the pair of jaws in 3 seconds or less. 1. An electrosurgical instrument , comprising:a power supply operatively coupled to an end effector,the end effector having a pair of jaws for effectuating an action on tissue positioned therebetween,the power supply configured to input a first signal and a second signal to a buck-boost converter, the buck-boost converter configured to transmit an output to an H-bridge circuit, the H-bridge circuit configured to pass a signal to a resonant LC transformer circuit, the power supply configured to transmit a power signal; andthe pair of jaws operatively coupled to the power supply to receive the power signal, the power having no more than 80 Volts RMS, and less than 2 Amps RMS, the power configured to seal the tissue positioned between the pair of jaws in 3 seconds or less.2. The instrument of claim 1 , wherein:the pair of jaws are configured to compress the tissue to a thickness of 0.005 inches or less.3. The instrument of claim 1 , wherein:the resonant LC transformer circuit comprises includes a capacitor, an inductor, and a transformer, wherein the transformer is a 1:9 transformer.4. The instrument of claim 1 , wherein:the power has 1.5 Amps or less.5. The instrument of claim 1 , wherein:the pair ...

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Номер записи: 23

03-02-2022 дата публикации

CONTROLLING IRREVERSIBLE ELECTROPORATION ABLATION USING A FOCAL CATHETER HAVING CONTACT-FORCE AND TEMPERATURE SENSORS

Номер: US20220031386A1

Автор: Altmann Andres Claudio, Govari Assaf

Принадлежит:

A catheter includes an insertion tube, first and second electrodes, and a contact-force sensor. The insertion tube is configured to insert the catheter into a patient body. The first and second electrodes are coupled to a distal-end of the catheter at a predefined distance from one another, and are configured to: (i) receive, via the insertion tube, one or more irreversible electroporation (IRE) pulses, and (ii) apply the IRE pulses, between the first and second electrodes, to tissue of the patient body. The contact-force sensor is disposed between the first and second electrodes and is configured to produce an electrical signal indicative of a contact force applied between the distal-end and the tissue. 1. A catheter , comprising:an insertion tube, which is configured to insert the catheter into a patient body;first and second electrodes, which are coupled to a distal-end of the catheter at a predefined distance from one another, and are configured to: (i) receive, via the insertion tube, one or more irreversible electroporation (IRE) pulses, and (ii) apply the IRE pulses, between the first and second electrodes, to tissue of the patient body; anda contact-force sensor, which is disposed between the first and second electrodes and is configured to produce an electrical signal indicative of a contact force applied between the distal-end and the tissue.2. The catheter according to claim 1 , and comprising a processor claim 1 , which is configured claim 1 , based on the electrical signal received from the contact-force sensor claim 1 , to control a supply of the one or more IRE pulses to the first and second electrodes.3. The catheter according to claim 2 , and comprising at least a temperature sensor claim 2 , which is coupled to the distal-end claim 2 , and is configured to produce a temperature signal claim 2 , indicative of a measured temperature of at least one of the distal-end and the tissue.4. The catheter according to claim 3 , wherein the temperature sensor ...

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Номер записи: 24

03-02-2022 дата публикации

Cautious irreversible-electroporation (ire) protocol for avoiding bubble generation

Номер: US20220031387A1

Автор: Assaf Govari

Принадлежит: Biosense Webster Israel Ltd

An irreversible electroporation (IRE) includes setting an initial IRE protocol for applying IRE pulses by electrodes of a catheter placed in contact with tissue in an organ. A notification is issued to a user upon determining that the initial IRE protocol is expected to cause bubbles in blood. In response to the notification, user input is received from the user, that selects between the initial IRE protocol and an alternative protocol that is not expected to cause the bubbles. The IRE pulses are applied according to the initial IRE protocol or the alternative IRE protocol, depending on the user input.

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Номер записи: 25

18-01-2018 дата публикации

CATHETERS AND METHODS FOR INTRACARDIAC ELECTRICAL MAPPING

Номер: US20180014883A1

Автор: GROVES Regina E., Knight Joseph Allen, LASKE Timothy G.

Принадлежит:

A method and system capable of identifying ectopic foci, rotors, or conduction pathways involved in reentrant arrhythmias within cardiac tissue, and then treating identified ectopic foci, rotors, and/or pathways with either lethal or sub-lethal temperatures. The system includes a medical device having one or more mapping elements and one or more treatment elements, and a computer programmable to identify ectopic foci and rotors based at least in part on signals received from the one or more mapping elements at one or more locations. 1. A method of locating and treating a source or pathway of electrical conduction within cardiac tissue , the method comprising:(a) positioning one or more mapping elements affixed to a distal end of medical device in contact with cardiac tissue at a first position, the medical device being in communication with a control system including a computer having a display and programmable to execute algorithms, the cardiac tissue being composed of cells;(b) executing computer algorithms to determine directional and morphological features of the electrical conduction of interest based at least in part on signals received by the computer from the one or more mapping elements at the first position;(c) displaying on the computer display a suggested second position at which the one or more mapping elements should be placed in contact with the cardiac tissue;(d) repositioning the one or more mapping elements at the second position;(e) executing computer algorithms to determine directional and morphological features of the electrical conduction of interest based at least in part on signals received by the computer from the one or more mapping elements at the second position;(f) repeating steps (a)-(e) until a source or pathway of the electrical conduction of interest is located; and(g) activating one or more treatment elements in contact with the cardiac tissue cells to treat the cells at a non-lethal temperature and disrupt the source or pathway of ...

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Номер записи: 26

21-01-2021 дата публикации

Ablation lesion quality

Номер: US20210015549A1

Автор: Ali Haghighi-Mood, Richard Jonathan Cohen

Принадлежит: Sirona Medical Technologies Inc

Improved ablation procedures and exemplary catheters for use with such procedures are provided. In one example, high quality homogenous lesions with well-defined borders can be created by introducing into a patient body a catheter that includes an electrode that is mounted on a distal end of the catheter, positioning the electrode to be in contact with tissue to be ablated such that at least 65 percent of an exposed distal surface area of the electrode is in contact with the tissue to be ablated, and applying electrical energy to the electrode sufficient to create an ablation lesion in the tissue.

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Номер записи: 27

10-02-2022 дата публикации

Intravascular arterial to venous anastomosis and tissue welding catheter

Номер: US20220039854A1

Автор: Brad M. Kellerman, David K. Wrolstad, David Trottingwolf Aldridge, Gene Reu, Jeffrey E. Hull, Mark A. Ritchart

Принадлежит: Avenu Medical Inc

A method of creating an AV fistula between adjacent first and second vessels includes inserting a guidewire from the first vessel into the second vessel. Inserting a catheter including a proximal member and a distal member over the guidewire such that a distal tip of the distal member comes into contact with a selected anastomosis site. Moving the distal member and the proximal member together to clamp tissue surrounding the aperture between the distal face of the proximal member and a proximal face on the distal member. Applying energy to an active heating member on the proximal member to cut and form the aperture, and to weld the edges thereof in order to create a desired fistula between the two vessels. Using a passive heating member disposed on the distal member to create a heating gradient across a tissue contacting surface of the distal member.

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Номер записи: 28

25-01-2018 дата публикации

Surgical Devices Having Controlled Tissue Cutting and Sealing

Номер: US20180021562A1

Автор: Hibner John A., Houser Kevin L., Strobl Geoffrey S., Yates David C.

Принадлежит: Ethicon LLC

Various surgical devices and methods are provided for monitoring and regulating tissue compression and cutting to improve tissue effect. In general, these devices include a handle portion, an elongate shaft, and an effector disposed at a distal end of the shaft and configured to engage tissue. In one embodiment, one or more sensors can be positioned at various locations on the device and can determine a force applied to tissue engaged by the end effector. When the force exceeds a threshold, a notification signal can be issued to a user. In another embodiment, a sensor can determine an amount of current moving between jaws of the end effector and a controller can slow a speed of the cutting element when the sensed current exceeds a threshold amount. 1. A surgical device , comprising:a proximal handle portion;an elongate shaft extending distally from the proximal handle portion;an end effector having first and second jaws coupled to a distal end of the elongate shaft, the first jaw including a first electrode element, and the second jaw including a second electrode element;an actuator configured to be actuated by a user and thereby cause a motor to provide power to move a cutting element at a speed along the end effector to cut tissue engaged between the first and second jaws;a sensor configured to sense current moving between the first and second electrode elements during the movement of the cutting element; anda controller configured to decrease the speed of the cutting element when the sensed current exceeds a threshold amount such that the cutting element continues moving along the end effector at a slower speed.2. The device of claim 1 , wherein the controller is configured to decrease the speed of the cutting element by causing a speed of the motor to decrease.3. The device of claim 1 , wherein the actuator is configured to control opening and closing of the first and second jaws.4. The device of claim 1 , wherein the first and second electrodes are configured ...

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Номер записи: 29

25-01-2018 дата публикации

Methods and Apparatus for Multi-Vessel Renal Neuromodulation

Номер: US20180021574A1

Автор: Zarins Denise

Принадлежит:

Methods and apparatus are provided for multi-vessel neuromodulation, e.g., via a pulsed electric field. Such multi-vessel neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, the multi-vessel neuromodulation is applied to neural fibers that contribute to renal function. Such multi-vessel neuromodulation optionally may be performed bilaterally. 132-. (canceled)33. A method of assessing efficacy of a renal neuromodulation procedure in a human patient , the method comprising:determining a baseline level of one or more biomarkers in plasma or urine collected from the patient;attenuating neural traffic along a renal nerve of the patient via energy delivery from an intravascularly-positioned neuromodulation assembly;determining a post-neuromodulation level for the biomarker(s) in plasma or urine collected from the human patient; andcomparing the post-neuromodulation level to the baseline level,wherein the neuromodulation procedure is classified as at least partially successful if the post-neuromodulation level differs from the baseline level.34. The method of wherein the one or more biomarkers includes a catecholamine.35. The method of wherein the one or more biomarkers includes norepinephrine.36. The method of wherein the one or more biomarkers includes norepinephrine in urine collected from the human patient.37. The method of wherein:determining a baseline level of one or more biomarkers includes determining a baseline level of one or more catecholamines in urine collected from the human patient; anddetermining a post-neuromodulation level for the biomarker(s) includes determining a post-neuromodulation level of the one or more catecholamines in urine collected from the human patient.38. The method of wherein the one or more ...

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Номер записи: 30

24-01-2019 дата публикации

APPARATUS AND METHODS OF INDUCING WEIGHT LOSS USING BLOOD FLOW CONTROL

Номер: US20190021890A1

Автор: Asirvatham Samuel J., Bingener-Casey Juliane, Bruce Charles J., Buttar Navtej S., Farrugia Gianrico, Friedman Paul A., Levy Michael J., Rajan Elizabeth, Wong Kee Song Louis-Michel

Принадлежит:

Methods and apparatus for inducing weight loss using blood flow control are described herein. The apparatus and methods operate by controlling blood flow to the stomach and/or small bowel. 112-. (canceled)13. A method of inducing weight loss , the method comprising reducing blood flow to the gastrointestinal tract by ablating one or more blood vessels that supply the stomach and/or small bowel to limit dilation of the blood vessels to increase flow after the ablating.14. A method according to claim 13 , wherein the ablating is configured to cause fibrosis of the one or more blood vessels that supply the stomach and/or small bowel claim 13 , wherein the fibrosis limits dilation of the blood vessels to increase flow.1518-. (canceled)19. A system for inducing weight loss claim 13 , the system comprising:a controller operably connected to one or more input devices, wherein the controller is configured to determine that a patient is ingesting food; andone or more blood flow constriction devices operably connected to the controller, the one or more blood flow constriction devices configured to reduce blood flow to the gastrointestinal tract.20. A system according to claim 19 , wherein the one or more input devices comprise one or more of: a sensor configured to detect distention and/or increased pressure in a stomach claim 19 , a sensor configured to detect swallowing claim 19 , and a sensor configured to detect flow into a stomach.21. A system according to claim 19 , wherein the one or more input devices comprise a direct input device actuated by a patient to provide a signal to the controller that food is being ingested.22. A system according to claim 19 , wherein the one or more blood flow constriction devices comprises a device configured to mechanically constrict one or more blood vessels that supply the stomach and/or small bowel.23. A system according to claim 19 , wherein the one or more blood flow constriction devices comprises a device configured to cool an ...

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Номер записи: 31

24-01-2019 дата публикации

Methods and Devices for Stimulating an Immune Response Using Nanosecond Pulsed Electric Fields

Номер: US20190022141A1

Автор: Athos Brian G., Berridge Jon, Kreis Mark P., Lui Kaying, Lum Joanne, Mallon Zachary R., Nuccitelli Pamela S., Nuccitelli Richard Lee

Принадлежит: Pulse Biosciences, Inc.

Nanosecond pulsed electric field (nsPEF) treatments of a tumor are adjusted based on a size and type of the tumor to stimulate an immune response against the tumor and other tumors in the subject. Calreticulin expression on tumor cells can be detected to confirm treatment. An immune response biomarker can be measured, and further nsPEF treatments can be performed if needed to stimulate or further stimulate the immune response. Cancers that have metastasized may be treated by directly treating a tumor that is most accessible. The treatment can be combined with CD47-blocking antibodies, doxorubicin, CTLA-4-blocking antibodies, and/or PD-1-blocking antibodies. Electrical characteristics of nsPEF treatments can be based on the size, type, and/or strength of tumors and/or a quantity of tumors in the subject. 1. A method for stimulating an immune response to a disease in a subject , the method comprising:determining a target treatment energy based on a size and a type of a tumor in the subject;selecting or allowing selection of a number of pulses, an amplitude of at least 10 kilovolts per centimeter, or a pulse length of between 0.1 nanoseconds and 1000 nanoseconds for sub-microsecond pulsed electric fields based on the determined target treatment energy; andapplying to the tumor, using a plurality of electrodes positioned in or around the tumor or a portion thereof, the sub-microsecond pulsed electric fields having the selected number of pulses, the selected amplitude, or the selected pulse length.2. The method of further comprising:adjusting the target treatment energy based on a comparison of a measured immune response biomarker before the applying and a measured immune response biomarker after the applying in a sample of the subject;determining a new number of pulses, a new amplitude, or a new pulse length based on the adjusted target treatment energy; and 'applying to the tumor, using the plurality of electrodes, sub-microsecond pulsed electric fields based on the ...

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Номер записи: 32

28-01-2021 дата публикации

FOURIER ANALYSIS SPECTROSCOPY FOR MONITORING TISSUE IMPEDANCE CHANGES AND TREATMENT OUTCOME DURING ELECTROPORATION-BASED-THERAPIES

Номер: US20210023362A1

Автор: ARENA Christopher B., Bhonsle Suyashree, Davalos Rafael V., EPSHTEYN LUCY, Lorenzo Melvin F., White Natalie

Принадлежит:

Electroporation-based therapies (EBTs) employ high voltage pulsed electric fields (PEFs) to permeabilize tumor tissue, resulting in changes in passive electrical properties detectable using electrical impedance spectroscopy (EIS). Currently, commercial potentiostats for EIS are limited by impedance spectrum acquisition time (˜10 s); this timeframe is much larger than pulse periods used with EBTs (˜1 s). Fourier Analysis SpecTroscopy (FAST) is introduced as a methodology for monitoring tissue inter-burst impedance (diagnostic FAST) and intra-burst impedance (therapeutic FAST) during EBTs. FAST is a rapid-capture (<<1 s) technique which enables monitoring of inter-burst and intra-burst impedance during EBTs in real-time. FAST identified a frequency which delineates thermal effects from electroporation effects in measured impedance. Significance: FAST demonstrates the potential to perform EIS, in addition to intra-burst impedance spectroscopy, using existing pulse generator topologies. 1. A method for monitoring administration of electrical pulses comprising:administering a plurality of electrical pulses to a material or a tissue;obtaining an impedance measurement or an impedance spectrum relating to the material or tissue;identifying any change in impedance relative to a reference impedance measurement; andmonitoring the administering to determine if a desired endpoint is reached as indicated by the change in impedance, and i) adjusting one or more parameters of, ii) stopping, iii) halting, and/or iv) continuing the administering based on the monitoring.2. The method of claim 1 , wherein the endpoint for electroporation is a point during the administering where the electroporation no longer contributes to any change in impedance.3. The method of claim 1 , wherein the reference impedance measurement is:a prior low-frequency impedance measurement or spectrum; ora reference high-frequency impedance measurement or spectrum.4. The method of claim 3 , wherein the endpoint ...

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Номер записи: 33

01-02-2018 дата публикации

CRYOGENIC BALLOON DEVICE WITH ELECTROPORATION TREATMENT REGION

Номер: US20180028252A1

Автор: LALONDE Jean-Pierre

Принадлежит:

An intravascular ablation device, including a flexible elongate body; an expandable element positioned on the elongate body; a radiofrequency or electroporation treatment segment located distally of the expandable element; a cryogenic coolant source in fluid communication with an interior of the expandable element; and a radiofrequency or electroporation energy source in communication with the radiofrequency or electroporation treatment segment. 1. A method of treating tissue , the method comprising: an elongate catheter body having a proximal portion and a distal portion;', 'an expandable first treatment region coupled to the distal portion of the elongate catheter body; and', 'a second treatment region coupled to the distal portion of the catheter body at a location that is distal to the cryogenic treatment region and defines an outer surface and a distal tip of the medical device;, 'positining a medical device proximate a first tissue area, the medical device includingactivating the expandable first treatment region to create a first treatment pattern in the first tissue area;deactivating the expandable first treatment region;repositioning the medical device such that the second treatment region is proximate a second tissue area; andactivating the second treatment region to treat a second treatment pattern in the second tissue area, the second treatment pattern being different than the first treatment pattern.2. The method of claim 1 , wherein the second treatment region is at least one of a radiofrequency treatment region and an electroporation treatment region.3. The method of claim 1 , wherein the second treatment region includes at least one electrode.4. The method of claim 3 , wherein the second treatment region is an electroporation treatment region.5. The method of claim 4 , further comprising a power source in communication with the at least one electrode and being configured to transmit electrical pulses claim 4 , activation of the second treatment ...

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Номер записи: 34

01-02-2018 дата публикации

Device and method for assisting in tissue ablation

Номер: US20180028261A1

Автор: Gladys Tsz Ling Chan, Junbo LI, Nick Qiu, Thomas Shu Yin Tang, Yinan Chen

Принадлежит: Koninklijke Philips NV

The embodiments disclose a device, method and system for assisting in the determination of one or more ablation regions for covering a target region to be ablated. The device comprises a processor configured to receive vascular structure information of vessels inside the target region and derive a parametric map for the target region based on the received vascular structure information, each value in the parametric map indicating a metric of a corresponding voxel of the target region to be inside the one or more ablation regions. The parametric map serves to assist in the determination of the one or more ablation regions.

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Номер записи: 35

17-02-2022 дата публикации

BALLOON PROBE FOR IRREVERSIBLE ELECTROPORATION

Номер: US20220047325A1

Автор: Adawi Eid, Auerbach Shmuel, Ziv-Ari Morris

Принадлежит:

An apparatus includes a shaft, configured for insertion into a body of a subject, an inflatable balloon coupled to a distal end of the shaft, and a plurality of electrodes coupled to a distal portion of the balloon that is perpendicular to a longitudinal axis of the distal end of the shaft when the balloon is inflated. Other embodiments are also described. 1. Apparatus for irreversible electroporation , the apparatus comprising:a shaft, configured for insertion into a body of a subject;an inflatable balloon coupled to a distal end of the shaft; anda plurality of electrodes coupled to a distal portion of the balloon that is perpendicular to a longitudinal axis of the distal end of the shaft when the balloon is inflated.2. The apparatus according to claim 1 , wherein the distal portion of the balloon is perpendicular to the longitudinal axis of the distal end of the shaft by virtue of an angle between (i) the longitudinal axis of the distal end of the shaft and (ii) a normal line to the distal portion of the balloon at any point on the distal portion of the balloon being less than 30 degrees.3. The apparatus according to claim 1 , wherein the electrodes are arranged in a grid.4. The apparatus according to claim 1 , wherein the shaft extends through the balloon and is coupled to the distal portion of the balloon.5. The apparatus according to claim 1 , further comprising at least one support rod proximally coupled to the shaft and distally coupled to the distal portion of the balloon.6. The apparatus according to claim 1 , wherein an area of the distal portion of the balloon is at least 10 mm.7. The apparatus according to claim 1 , wherein the balloon comprises a distal surface comprising the distal portion of the balloon.8. The apparatus according to claim 7 , wherein the distal surface has a circular perimeter.9. The apparatus according to claim 7 , further comprising one or more sensors coupled to the distal surface.10. A method for performing irreversible ...

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Номер записи: 36

17-02-2022 дата публикации

Applying Bipolar Ablation Energy Between Shorted Electrode Groups

Номер: US20220047326A1

Автор: Andres Claudio Altmann, Assaf Govari

Принадлежит: Biosense Webster Israel Ltd

A system includes a catheter, a switching assembly, and a processor. The catheter including an expandable frame, which is coupled to a distal end of the catheter, and multiple electrodes, which are disposed on the expandable frame in a radial geometry. The switching assembly is electrically connected to the catheter, and is configured to electrically short between selected ones of the electrodes. The processor is configured, for first and second disjoint groups of the electrodes, to control the switching assembly to electrically short the electrodes within each of the first and second groups, for applying one or more bipolar ablation energy between the first and second groups when the electrodes are placed in contact with a target tissue of the organ.

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Номер записи: 37

31-01-2019 дата публикации

Expandable elements for delivery of electric fields

Номер: US20190030328A1

Автор: Brian T. HOWARD, Mark T. Stewart

Принадлежит: MEDTRONIC INC

A method, system, and device for electroporation. A system may include a medical device with a plurality of electrodes borne on an expandable element and an energy generator in communication with the electrodes. The energy generator may have processing circuitry configured to selectively deliver electroporation energy to at least one of the electrodes. The processing circuitry may determine whether an alert condition is present and, if so, cease the delivery of electroporation energy to one or more electrodes identified as the cause of the alert condition and/or prevent the delivery of electroporation energy to the one or more electrodes identified as the cause of the alert condition. The energy generator may also be configured to deliver electroporation energy in a sequence of a plurality of energy delivery patterns to enhance lesion formation.

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Номер записи: 38

04-02-2021 дата публикации

Methods of Sterilization and Treating Infection Using Irreversible Electroporation

Номер: US20210030463A1

Автор: Robert Pearson

Принадлежит: Angiodynamics Inc

A method for treating an infection using irreversible electroporation is presented. The method includes providing an ablation device that has at least one electrode and inserting the ablation device into a target tissue of a patient. The tissue at least partially surrounds the implanted medical device. The outer surface of the medical device is at least partially covered by infectious cells. The method also involves positioning at least one electrode in or near the implanted medical device and delivering electrical pulses to or near the implanted medical device sufficient to irreversibly electroporate the infectious cells.

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Номер записи: 39

04-02-2021 дата публикации

Catheters, catheter systems, and methods for puncturing through a tissue structure and ablating a tissue region

Номер: US20210031020A1

Автор: Steven Richard Mickelsen

Принадлежит: University of Iowa Research Foundation UIRF

A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. The ablation catheter can include electrodes positioned within a central portion. The ablation catheter is positioned such that the central portion of a flexible shaft at least partially surrounds the selected tissue region. Each electrode of the ablation catheter can be activated independently to apply ablative energy to the selected tissue region. The ablation catheter can employ high impedance structures to change the current density at specific points. Methods of puncturing through a tissue structure using the percutaneous catheter system are disclosed. Also disclosed are methods for ablating a selected tissue region using the ablation catheter.

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Номер записи: 40

07-02-2019 дата публикации

Ablation check pulse routine and integration for electroporation

Номер: US20190038171A1

Автор: Brian T. HOWARD

Принадлежит: MEDTRONIC INC

Devices, systems, and methods relating to a low-voltage, pre-treatment pulse routine for evaluating a potential for non-target tissue damage from the delivery of energy, such as electroporation energy to an area of target tissue. In one embodiment, a medical system includes a medical device having a treatment element; and a control unit in communication with the medical device, the control unit being configured to: deliver a low-voltage, pre-treatment pulse routine through the treatment element to an area of target tissue; determine whether the low-voltage, pre-treatment pulse routine has a stimulation effect on an area of non-target tissue; and deliver an ablation energy routine through the treatment element to the area of target tissue when the control unit determines that the low-voltage, pre-treatment pulse routine does not have a stimulation effect on the area of non-target tissue.

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Номер записи: 41

07-02-2019 дата публикации

Instrument For Therapeutically Cytotoxically Ablating Parathyroidal Tissue Within A Parathyroid Gland

Номер: US20190038334A1

Автор: Schwartz Alan N.

Принадлежит:

An instrument for therapeutically cytotoxically ablating parathyroidal tissue is disclosed. A substance is capable of transforming the parathyroid gland from overproduction of parathyroid hormone when the substance's quantity exceeds a set amount, and is capable of transforming the parathyroid gland from overproduction only when activated by application of sufficient units of an electromagnetic energy having a frequency ranging from 400 THz to 30 PHz when the substance's quantity is below the set amount. A delivery device is operable to introduce the substance into the parathyroidal tissue and to quantitatively limit the quantity to below the set amount. An energy device is operable to apply units of the electromagnetic energy after the substance has been introduced. A sensor is operable to monitor the activation of the substance as the electromagnetic energy is applied. The energy device is further operable to modulate applying the electromagnetic energy when the substance has been activated. 1. An instrument for therapeutically cytotoxically ablating parathyroidal tissue within a parathyroid gland , comprising:a substance capable of cytotoxic ablation of a parathyroid gland of a living human, wherein the substance alone is capable of transforming the parathyroid gland from overproduction to non-overproduction of parathyroid hormone when a quantity of the substance exceeds a set amount, and the substance is capable of transforming the parathyroid gland from overproduction to non-overproduction of the parathyroid hormone only when activated in the parathyroidal tissue by application of sufficient units of an electromagnetic energy having a frequency ranging from 400 THz to 30 PHz when the quantity of the substance is below the set amount;a substance delivery device operable to introduce the substance into the parathyroidal tissue and to quantitatively limit the quantity of the substance being introduced to below the set amount;an electromagnetic energy treatment ...

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Номер записи: 42

07-02-2019 дата публикации

ELECTROMANIPULATION OF CELLS AND OTHER BIOLOGICAL TISSUES BY PULSEDELECTRIC FIELDS AT ELEVATED TEMPERATURES

Номер: US20190038337A1

Автор: Beebe Stephen P., CAMP James, DONATE Amy, Heller Richard, SCHOENBACH Karl H., Xiao Shu

Принадлежит:

Systems and methods for treatment of a biological tissues including target tissues and other tissues. The method includes elevating a temperature of the target tissues above a physiological temperature of the biological tissues to treatment temperature, and generating an electric field extending through at least a portion of the target tissues using a pre-defined sequence of short voltage pulses applied between at least two electrodes. In the method, the treatment temperature is maintained during the generating. Further, the pre-defined sequence is selected such that a magnitude of the electric field generated is sufficient to induce electromanipulation in the portion of the target tissues without substantially elevating of the temperature of the portion of the target tissues above the treatment temperature. 121-. (canceled)22. A method for treatment of biological tissues comprising a target tissue , comprising:causing a temperature of the target tissue to be elevated and maintained at a treatment temperature range which is above a physiological temperature of the biological tissues and at or below about 47° C.;generating, during the causing, an electric field extending through at least a portion of the target tissue using a pre-defined sequence of short duration voltage pulses applied between at least two electrodes; andsynchronizing maintaining of the treatment temperature range to overlap with applying the pre-defined sequence of short duration voltage pulses, andwherein the pre-defined sequence of short duration voltage pulses is selected such that a magnitude of the electric field is configured to deliver an electrical energy sufficient to induce cell death in the portion of the target tissue at the treatment temperature range and that is lower than a specific electrical energy sufficient to induce cell death in the portion of the target tissue at or below the physiological temperature.23. The method of claim 22 , wherein the treatment temperature range is ...

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Номер записи: 43

07-02-2019 дата публикации

TISSUE ABLATION AND MONITORING THEREOF

Номер: US20190038350A1

Автор: Claude John P., SALAHIEH Amr, SAUL Tom

Принадлежит:

An ablation catheter including an elongate shaft, an inflatable balloon positioned at a distal region of the elongate shaft, a first ablation electrode disposed outside of and carried by an outer surface of the inflatable balloon, a first ultrasound transducer disposed outside of the inflatable balloon, and a flexible circuit. The flexible circuit includes a first conductor and a second conductor and is disposed outside of and carried by the outer surface of the inflatable balloon. The first conductor is in electrical communication with the first ablation electrode, and the second conductor in electrical communication with the first ultrasound transducer. 1. An ablation catheter , comprising:an elongate shaft;an inflatable balloon positioned at a distal region of the elongate shaft;a first ablation electrode disposed outside of and carried by an outer surface of the inflatable balloon;a first ultrasound transducer disposed outside of the inflatable balloon; anda flexible circuit, including a first conductor and a second conductor, disposed outside of and carried by the outer surface of the inflatable balloon, the first conductor in electrical communication with the first ablation electrode, and the second conductor in electrical communication with the first ultrasound transducer.2. The ablation catheter of claim 1 , wherein the first ultrasound transducer is positioned within a periphery of the first ablation electrode.3. The ablation catheter of claim 1 , wherein the first ultrasound transducer is disposed under the first ablation electrode.4. The ablation catheter of claim 1 , wherein the first ultrasound transducer is an ultrasound receiver.5. The ablation catheter of claim 1 , wherein the first ultrasound transducer is an ultrasound emitter.6. The ablation catheter of claim 1 , wherein the first ultrasound transducer is at least partially surrounded by an insulation layer.6. The ablation catheter of claim 1 , further comprising:a second ultrasound transducer ...

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Номер записи: 44

06-02-2020 дата публикации

APPLIANCE FOR CONVEYING A CATHETER, LIGHT GUIDE OR CABLE IN A CONTROLLED MANNER

Номер: US20200038106A1

Автор: PIEPER Karl, SCHMUCK Thilo

Принадлежит:

The device serves for the controlled conveying of a cable. The device has a housing, having a cover plate, on which are externally mounted a drive wheel and contact wheel which can be radially pressed onto the drive wheel, between which the cable can be clamped. The cable can be conveyed by means of the drive wheel being driven by a drive unit in the interior of the housing. The rotational motion of the drive wheel is guided through a stationary light barrier by means of a counting disc, running synchronously therewith and having radial slots or holes in the circumferential area, for determining the motion and rotational speed of the drive wheel. The cover plate and the housing can be sterilized. The drive unit in the interior of the housing is not sterilizable, yet is completely enclosed by the sterilized housing and cover plate. 112.-. (canceled)13. A device for the controlled conveying of a cable in the form of a catheter having a light guide or a glass fiber or of an electric cable or of a cable-like tubelet , the device comprising: a drive wheel and a contact wheel which can be pressed radially onto the drive wheel , between which the cable to be conveyed can be clamped , so that it is conveyable by the drive of the drive wheel of a drive unit having an appurtenant control unit , and electronic controls and the rotational motion and rotational speed of the drive wheel are measurable by means of a measuring device ,wherein the apparatus is designed in three parts, having firstly a cover plate which can be sterilized to at least 180° C. and on which are externally mounted the drive wheel and the contact wheel outside which can be radially pressed onto said drive wheel, secondly a non-sterilizable drive unit having an electronic control, an electric motor, a reduction gear and a power supply, and thirdly a box-shaped housing which can be sterilized to at least 180° C. and into which the drive unit can be completely inserted and can be closed sterilely with the ...

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Номер записи: 45

15-02-2018 дата публикации

ELECTROSURGICAL (RF) MEDICAL INSTRUMENTS FOR CUTTING AND COAGULATING TISSUE

Номер: US20180042658A1

Автор: Aronhalt Taylor W., Baxter, Houser Kevin L., Hunt John V., III Chester O., IV Frederick E., Mallow Jennifer M., Shelton, Strobl Geoffrey S., Worrell Barry C., Yates David C.

Принадлежит:

An electrosurgical device is disclosed. The electrosurgical device includes a handle, a shaft extending distally from the handle, and an end effector coupled to a distal end of the shaft. The end effector comprises a first electrode and a second electrode. The second electrode includes a first position and a second position. The second electrode is configured to move from the first position to the second position when a force is applied to the end effector by a tissue section. The first electrode and the second electrode define a treatment area when the second electrode is in the second position. 1. An electrosurgical instrument comprising:a pencil-grip handle;a shaft coupled to the pencil grip handle; and a body;', 'a source electrode; and', 'one or more return electrodes,, 'an end effector coupled to the shaft, wherein the end effector compriseswherein the source electrode and the one or more return electrodes are configured to provide an electrosurgical signal to a tissue.2. The electrosurgical instrument of claim 1 , wherein the electrosurgical signal comprises a radio frequency (RF) signal.3. The electrosurgical instrument of claim 1 , wherein the pencil-grip handle comprises a power source and is cordless.4. The electrosurgical instrument of claim 1 , wherein the source electrode is disposed on a center portion of the body and the one or more return electrodes are disposed on a lateral portion of the body.5. The electrosurgical instrument of claim 1 , wherein the body defines an oval shape.6. The electrosurgical instrument of claim 1 , wherein the one or more return electrodes each comprise a first return electrode and a second return electrode.7. The electrosurgical instrument of claim 6 , further comprising an electrosurgical generator coupled to the end effector claim 6 , wherein the electrosurgical generator is configured to produce the electrosurgical signal comprising a first phase claim 6 , a second phase claim 6 , and a third phase claim 6 , wherein ...

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Номер записи: 46

15-02-2018 дата публикации

ELECTROSURGICAL SYSTEM ENERGY SOURCE

Номер: US20180042661A1

Автор: Bakos Gregory J., Long Gary L., Plescia David N.

Принадлежит:

An energy source for use with an electrosurgical system is disclosed. In one embodiment, the energy source includes a power supply, one or more capacitors coupled to the power supply, and a switching component coupled to the one or more capacitors. The switching component is configured to output pulses of a biphasic waveform. The pulses are capable of treating undesired tissue by inducing a change in voltage potential across cell membranes of a plurality of cells in the undesired tissue to promote non-thermal cell death in the plurality of cells. The pulses are also capable of treating the undesired tissue with no or minimal muscle contractions in patient tissue within reach of the biphasic waveform during treatment of the undesired tissue. 124-. (canceled)25. An electrosurgical system , comprising:an energy source; anda plurality of electrodes, wherein each of the plurality of electrodes is coupled to the energy source, and wherein each of the plurality of electrodes is positionable for electrical contact with target tissue;wherein the energy source is configured to deliver, via the plurality of electrodes, a plurality of pulses of biphasic radio frequency (RF) waveform to the target tissue, wherein the biphasic RF waveform operates at a fundamental frequency greater than that which electrically stimulates muscular cells, and wherein the plurality of pulses induce non-thermal cell death in the target tissue without a measurable stimulation in muscular tissue exposed to the biphasic RF waveform.26. The electrosurgical system of claim 25 , wherein the plurality of electrodes comprises at least two electrodes.27. The electrosurgical system of claim 25 , wherein the energy source comprises an alternating current waveform generator.28. The electrosurgical system of claim 25 , wherein the biphasic RF waveform operates at the fundamental frequency of about 330 KHz to about 900 KHz and a peak-to-peak voltage amplitude of about 200 VAC to about 12 claim 25 ,000 VAC.29. The ...

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Номер записи: 47

15-02-2018 дата публикации

METHODS AND APPARATUS FOR SELECTIVE TISSUE ABLATION

Номер: US20180042674A1

Автор: Mickelsen Steven Richard

Принадлежит:

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes. 120-. (canceled)21. A method , comprising:identifying, via a selection module of an electrode controller, a plurality of anode/cathode pairs from a plurality of electrodes of a multi-electrode catheter, the multi-electrode catheter configured to be disposed about a portion of a heart, at least one anode/cathode pair including at least one anode electrode and at least one cathode electrode;conveying a pacing signal to a pacing lead configured to be operatively coupled to the heart;receiving, at a feedback module of the electrode controller, an electrocardiograph signal associated with a function of the heart; anddelivering, via a pulse delivery module of the electrode controller, a pulsed voltage waveform to the plurality of anode/cathode pairs according to a sequential pattern, the pulsed voltage waveform including a pre-polarizing pulse followed by a polarizing pulse, the pre-polarizing pulse being generated by utilizing voltage spikes generated from switching on a discharge of a capacitor bank.22. The method of claim 21 , wherein the identifying is based on an input ...

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Номер записи: 48

15-02-2018 дата публикации

METHODS AND APPARATUS FOR MULTI-CATHETER TISSUE ABLATION

Номер: US20180042675A1

Автор: Long Gary L.

Принадлежит:

Catheter systems, tools and methods are disclosed for the selective and rapid application of DC voltage to drive irreversible electroporation, with the system controller configurable to apply voltages to an independently selected subsets of electrodes, such that voltages of one polarity are applied to a multiplicity of electrodes on a first medical device and voltages of the opposite polarity to a multiplicity of electrodes on a second medical device. The first and second medical devices can be epicardial catheters positioned such that their opposing distal tips are approximately aligned and whose segments with electrodes collectively wrap around the pulmonary veins. 116-. (canceled)17. A method , comprising:identifying, via a selection module of an electrode controller, a plurality of anode/cathode pairs, each anode selected in the plurality of anode/cathode pairs being only in a first plurality of electrodes of a first multi-electrode catheter, each cathode selected in the plurality of anode/cathode pairs being only in a second plurality of electrodes of a second multi-electrode catheter, the first multi-electrode catheter and the second multi-electrode catheter configured to collectively surround a portion of a heart;conveying a pacing signal to a pacing lead configured to be operatively coupled to the heart;delivering, via a pulse delivery module of the electrode controller, a first output signal having a first polarity to each anode selected; anddelivering, via the pulse delivery module, a second output signal having a second polarity opposite the first polarity to each cathode selected, the first output signal and the second output signal being delivered according to a sequential pattern.18. The method of claim 17 , wherein the identifying is based on an input received from an input/output module of the electrode controller.19. The method of claim 17 , further comprising:computing an impedance between at least one anode electrode in the first plurality of ...

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Номер записи: 49

14-02-2019 дата публикации

TISSUE ABLATION WITH IRREVERSIBLE ELECTROPORATION

Номер: US20190046255A1

Автор: Davalos Rafael, Rubinsky Boris

Принадлежит: The Regents of the University of California

A new method for the ablation of undesirable tissue such as cells of a cancerous or non-cancerous tumor is disclosed. It involves the placement of electrodes into or near the vicinity of the undesirable tissue through the application of electrical pulses causing irreversible electroporation of the cells throughout the entire area of the undesirable tissue. The electric pulses irreversibly permeate the cell membranes, thereby invoking cell death. The irreversibly permeabilized cells are left in situ and are removed by the body immune system. The amount of tissue ablation achievable through the use of irreversible electroporation without inducing thermal damage is considerable. 1. A method of ablating tissue cells , comprising the steps of:placing one or more electrodes near the tissue cells;applying a set of electrical pulses through the one or more electrodes, the set of electrical pulses comprised of at least one individual pulse having a pulse length of no more than 100 microseconds, the set of electrical pulses is applied in an amount sufficient to induce irreversible electroporation of the tissue cells but is insufficient to induce thermal damage to substantially all of the tissue cells such that the tissue cells are ablated by irreversible electroporation.2. The method of claim 1 , wherein the set of electrical pulses are applied for a duration in a range of from about 5 microseconds to about 62 seconds.3. The method of claim 1 , wherein at least one individual pulse of the applied set of electrical pulses has a pulse length of no more than 5 microseconds.4. The method of claim 1 , wherein at least 15 individual pulses are applied.5. The method of claim 1 , wherein at least 8 pulses are applied claim 1 , each of the 8 pulses have a pulse length up to 100 microseconds.6. The method of claim 1 , wherein the applied set of electrical pulses produce a voltage gradient up to 8000 volt/cm.7. The method of claim 1 , wherein a first electrode is placed at about 5 mm to ...

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Номер записи: 50

25-02-2016 дата публикации

Medical instrument electrically energized using drive cables

Номер: US20160051318A1

Автор: Richard D. Gresham, Scott E. Manzo, William A. Burbank

Принадлежит: Intuitive Surgical Operations Inc

An electrically energized medical instrument uses one or more drive cables to both actuate mechanical components of a wrist mechanism or an effector and to electrically energize the effector. Electrical isolation can be achieved using an insulating main tube through which drive cables extend from a backend mechanism to the effector, an insulating end cover that leaves only the desired portions of the effector exposed, and one or more seals to prevent electrically conductive liquid from entering the main tube. Component count and cost may be further reduced using a pair of pulleys that are shared by four drive cables.

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Номер записи: 51

25-02-2021 дата публикации

ENHANCED TREATMENT VOLUME AND SELECTIVE ABLATION USING ELECTROPORATION WITH ADJUVANT CALCIUM

Номер: US20210052882A1

Автор: Davalos Rafael V., Wasson Elisa M.

Принадлежит:

High-frequency irreversible electroporation (H-FIRE) is an electroporation-based therapy used to ablate cancerous tissue. Treatment consists of delivering short pulses in a series of bursts. Reducing pulse duration leads to reduced treatment volumes compared to traditional IRE, therefore larger voltages are typically applied to generate ablations comparable in size. Administration of adjuvant calcium enhances ablation area in vitro for H-FIRE treatments of several pulse durations. Furthermore, H-FIRE treatment delivered with CaClresults in cell death thresholds higher than that of H-FIRE without calcium and comparable to IRE thresholds without calcium. Quantifying the reversible electroporation threshold revealed that CaClenhances the permeabilization of cells compared to a NaCl control. H-FIRE treatment with calcium enhances the IRE to thermal cell death ratio, thereby also enhancing the positive immune response from treatment. 1. A method of treating tissue comprising:applying a plurality of electrical pulses to a tissue region; andexposing the tissue region to one or more agent;wherein the applying of the electrical pulses is performed in a manner sufficient to treat cells of the tissue region with high-frequency irreversible electroporation (H-FIRE); andwherein the agent is capable of protecting cells from, enhancing or increasing, and/or inhibiting, decreasing, or limiting, one or more effects of the H-FIRE.2. The method of claim 1 , wherein one or more of the effects of the H-FIRE is chosen from cell death; quick cell death on the order of seconds or minutes; slow cell death on the order of hours claim 1 , days claim 1 , weeks claim 1 , months or years; apoptosis; necrosis; heat; thermal effects; cell membrane permeabilization; inflammatory response; blood brain barrier disruption; transient blood brain barrier disruption; permanent damage; transient damage; immune response; a reversible electroporation zone and combinations thereof.3. The method of claim 1 , ...

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Номер записи: 52

10-03-2022 дата публикации

IRE Ablation Systems and Protocols Using a Basket Catheter

Номер: US20220071694A1

Автор: Andres Claudio Altmann, Assaf Govari, Lilah Marziano, Yuri Shamis

Принадлежит: Biosense Webster Israel Ltd

A medical apparatus includes a probe, including an insertion tube configured for insertion into a body cavity of a patient and a basket assembly, which has a proximal end that is connected distally to the insertion tube and includes a plurality of resilient spines, which are configured to bow radially outward around a longitudinal axis of the basket assembly and are conjoined at a distal end of the basket assembly. A plurality of electrodes are configured to contact tissue in the body cavity and include radial electrodes disposed on the spines and an axial electrode disposed on the longitudinal axis of the basket assembly. An electrical signal generator is configured to apply to the electrodes, including the axial electrode, pulses having an amplitude sufficient to cause irreversible electroporation (IRE) in the tissue contacted by the electrodes.

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Номер записи: 53

10-03-2022 дата публикации

Electroporation for obesity or diabetes treatment

Номер: US20220071700A1

Автор: Barham K. ABU DAYYEH, Christopher V. DESIMONE, Samuel J. Asirvatham

Принадлежит: Mayo Foundation for Medical Education and Research

Endolumenal devices and methods can be used for the treatment of health conditions including obesity and diabetes. In some embodiments, the methods and systems provided herein can cause weight loss or control diabetes by reducing the caloric absorption of an individual. For example, this document provides several devices and methods for treating obesity and diabetes by using electroporation to modulate the duodenal mucosa. In addition, this document provides devices and methods for bypassing portions of the gastrointestinal tract to reduce nutritional uptake.

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Номер записи: 54

04-03-2021 дата публикации

ENDOSCOPIC ULTRASOUND ELECTROPORATION

Номер: US20210059759A1

Автор: ABU DAYYEH Barham K., Asirvatham Samuel J.

Принадлежит: Mayo Foundation for Medical Education and Research

Cystic lesions can be treated by electroporation. For example, this document describes methods and devices for endoscopic ultrasound-guided ablation of cystic lesions using a needle for electroporation. 1. A method of performing electroporation , the method comprising:inserting a needle into a working channel of an endoscope;advancing the needle such that a distal end portion of the needle emerges from the working channel;inserting the distal end portion of the needle into a cyst using endoscopic ultrasound guidance;removing a first fluid from the cyst via a first aperture defined by the distal end portion of the needle;injecting a second fluid into the cyst; andgenerating an electrical field via an electrode on the distal end portion of the needle, wherein the electrical field is conducted by the second fluid to cause non-thermal electroporation of cells of the cyst.2. The method of claim 1 , further comprising inflating a balloon located on the distal end portion of the needle claim 1 , wherein the electrode is located on an outer surface of a wall of the balloon claim 1 , wherein the second fluid is injected into the cyst via a second aperture defined by a wall of the balloon claim 1 , and wherein the balloon is inflated using the second fluid or a gas.35.-. (canceled)6. The method of claim 1 , wherein the second fluid is injected into the cyst via at least one of: (i) the first aperture and (ii) a second aperture defined by the distal end portion of the needle.7. The method of claim 6 , further comprising injecting a chemotherapeutic agent into the cyst via at least one of the first aperture or the second aperture claim 6 , wherein the chemotherapeutic agent causes chemoelectroablation of the cyst.8. The method of claim 6 , further comprising injecting a photosensitizing agent into the cyst via at least one of the first aperture or the second aperture claim 6 , wherein the photosensitizing agent causes enhanced claim 6 , limited claim 6 , and target ablation of ...

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Номер записи: 55

02-03-2017 дата публикации

ULTRASONIC SURGICAL INSTRUMENT WITH ROTATABLE ACTUATION LEVERS AND MECHANICAL LOCKOUT

Номер: US20170056051A1

Автор: Dickerson Benjamin D., Faller Craig N.

Принадлежит:

An ultrasonic instrument includes a body, an actuation assembly, a shaft assembly, an ultrasonic blade, and a mechanical lockout. The body is configured to receive an ultrasonic transducer. The actuation assembly includes an activation lever that is configured to move from a first activation position toward the longitudinal axis to a second activation position. The activation lever is oriented obliquely relative the longitudinal axis in the second activation position. The shaft assembly includes an acoustic waveguide. The ultrasonic blade is in acoustic communication with the acoustic waveguide. The activation lever is operable to trigger ultrasonic activation of the ultrasonic blade by moving to the second activation position. The mechanical lockout is operable to selectively restrict movement of the first activation lever to the second activation position. 1. An ultrasonic instrument comprising:(a) a body, wherein the body defines a longitudinal axis, wherein the body is configured to receive an ultrasonic transducer;(b) an actuation assembly, wherein the actuation assembly comprises a first activation lever, wherein the first activation lever is configured to move from a first activation position toward the longitudinal axis to a second activation position, wherein the first activation lever is oriented obliquely relative the longitudinal axis in the second activation position;(c) a shaft assembly, wherein the shaft assembly comprises an acoustic waveguide;(d) an ultrasonic blade, wherein the ultrasonic blade is in acoustic communication with the acoustic waveguide, wherein the first activation lever is operable to trigger ultrasonic activation of the ultrasonic blade by moving to the second activation position; and(e) a mechanical lockout, wherein the mechanical lockout is operable to selectively restrict movement of the first activation lever to the second activation position.2. The ultrasonic instrument of claim 1 , further comprising a control circuit ...

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Номер записи: 56

15-05-2014 дата публикации

System and method for electrical stimulation of the lumbar vertebral column

Номер: US20140135876A1

Автор: John D. LIPANI

Принадлежит: Individual

Disclosed methods and devices treat lower back pain from degenerated or injured intervertebral discs. Electrodes connected to a pulse generator deliver electrical impulses to nerves located within the posterior longitudinal ligament and posterior annulus fibrosus of lumbar intervertebral discs. Percutaneous and paddle leads containing the electrodes are disclosed. The percutaneous lead, designed to prevent inappropriate stimulation of the thecal sac, is inserted in the anterior epidural space using a special cannula and lead blank. Paddle leads are configured individually for implantation in each patient. The electrical stimulation may reduce back pain reversibly, with or without the simultaneous use of non-thermal irreversible electroporation. If such stimulation is unsuccessful, nerves in the ligament or annulus fibrosus may then be injured therapeutically without repositioning the lead, using impulses that result in heating, wherein a thermal insulator covers the thecal sac, thereby shielding nerves within the thecal sac from potential heat damage.

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Номер записи: 57

20-02-2020 дата публикации

ELECTRODE INTRODUCER DEVICE

Номер: US20200054874A1

Автор: Gehl Karen Julie, Videbaek Karsten

Принадлежит:

A method of generating an electric field in a target region of a patient includes inserting a set of electrodes having respective distal ends enclosed within a single elongate introducer shaft having a distal tip, into the vicinity of the target region; extending at least a pair of the electrodes to an extended position such that the electrode distal ends are deflected away from a longitudinal axis of the shaft in such a way that at least one planar projection taken in a plane perpendicular to the longitudinal axis of a distance between a pair of distal ends of the electrodes is larger than a maximal extent of a cross-section of the introducer shaft, the cross-section taken in a plane perpendicular to the a longitudinal axis at a distal end of the introducer shaft; and applying one or more electric pulses to the target tissue through the electrodes. 139-. (canceled)40. An electroporation device comprisinga handle section;an elongate introducer shaft connected to said handle section, said introducer shaft having a distal tip; and{'b': 1', '2, 'a set of electrodes having respective distal ends, each electrode being slidably arranged within said introducer shaft and said tip from a retracted position, where said distal ends are enclosed within said introducer shaft, to an exposed position, where said distal ends extend from said distal tip; wherein said electrode distal ends are deflectable away from a longitudinal axis (L) of said shaft when deployed/extended to their extended position, such that at least one planar projection taken in a plane perpendicular to said longitudinal axis (L) of a distance (D) between a pair of distal ends of said electrodes is larger than a maximal extent (D) of a cross-section of said introducer shaft, said cross-section taken in a plane perpendicular to said longitudinal axis (L) at a distal end of said introducer shaft,'}wherein the deflection of said distal ends of said electrodes, when in their extended position, is provided by a ...

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Номер записи: 58

28-02-2019 дата публикации

ELECTROPORATION DELIVERY SYSTEMS AND METHODS OF USING ELECTROPORATION DELIVERY SYSTEMS

Номер: US20190060632A1

Автор: Asirvatham Samuel J., Gruba Sarah M., Kapa Suraj, Killu Ammar M., Naksuk Niyada, Pagoria Douglas D., Rohl James P., Witt Chance M.

Принадлежит:

The present disclosure relates generally to electroporation systems and utilizing algorithms for electroporation pulse delivery including a patient's EKG/EGM monitoring. In some embodiments, an electroporation delivery system may include an electrocardiogram operatively connected to a processing device and a memory. One or more sensors may be operatively connected to the electrocardiogram for measuring electrical activity QRS complex of a patient's heart. One or more electrodes for treatment may be disposed in, at, or near the patient's heart, the one or more electrodes operatively connected to a pulse delivery mechanism. The electroporation delivery system may be configured to determine whether an electroporation pulse is deliverable to a patient based on the electrocardiogram. 1. An electroporation delivery system , comprising:an electrocardiogram operatively connected to a processing device and a memory;one or more sensors operatively connected to the electrocardiogram for measuring electrical activity QRS complex of a patient's heart; andone or more electrodes for treatment in, at, or near the patient's heart, the one or more electrodes operatively connected to a pulse delivery mechanism;wherein the electroporation delivery system is configured to determine whether an electroporation pulse is deliverable to a patient based on the electrocardiogram.2. The electroporation delivery system according to claim 1 , wherein the processing device is configured to execute the following steps:measuring and averaging approximately 30 initial heartbeat durations of the patient's heart;calculating a rolling average by averaging a series of four heartbeat durations; andcomparing the rolling average to the averaged initial heartbeat durations including a standard deviation;wherein if the rolling average is equal to the average initial heartbeat durations within the standard deviation, delivering the electroporation pulse during a fifth heartbeat duration following the averaged ...

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Номер записи: 59

17-03-2022 дата публикации

Methods and apparatus for modifying or killing cells by manipulating the cell membrane charging time

Номер: US20220080192A1

Автор: Christopher FESMIRE, Michael Benjamin Sano, Ross A. PETRELLA

Принадлежит: North Carolina State University

A method of treatment includes modifying and/or killing cells by changing the cell membrane charging time to make the cells more susceptible to the influence of electric fields. The method may further include inserting one or more electrodes into tissue, acquiring a temperature of the tissue, delivering electrical energy to the tissue by electrical pulses, determining a rate of energy delivery of the electrical energy such that the temperature rises above a first critical temperature but remains below a second critical temperature, and delivering the electrical energy until a specific dose is achieved.

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Номер записи: 60

09-03-2017 дата публикации

Methods and apparatus for selective tissue ablation

Номер: US20170065339A1

Автор: Steven R. MICKELSEN

Принадлежит: Farapulse Inc

Catheter systems and methods for the selective and rapid application of DC voltage to drive irreversible electroporation are disclosed herein. In some embodiments, an apparatus includes a voltage pulse generator and an electrode controller. The voltage pulse generator is configured to produce a pulsed voltage waveform. The electrode controller is configured to be operably coupled to the voltage pulse generator and a medical device including a series of electrodes. The electrode controller includes a selection module and a pulse delivery module. The selection module is configured to select a subset of electrodes from the series of electrodes. The selection module is configured identify at least one electrode as an anode and at least one electrode as a cathode. The pulse delivery module is configured to deliver an output signal associated with the pulsed voltage waveform to the subset of electrodes.

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Номер записи: 61

15-03-2018 дата публикации

System and Methods for Irreversible Electroporation with Thermally Controlled Electrodes

Номер: US20180071014A1

Автор: Goldberg Nahum S., NEAL Robert, Single Gordon

Принадлежит:

A treatment device and method for delivering electrical pulses capable of creating irreversible electroporation. The system may include a bipolar probe with open or closed perfusion with the purpose of controlling the electrical conductivity rise to eliminate electrical arcing, without significantly altering the electric field distribution and treatment zone. This invention may include perfusion together with the delivery of specific or customized pulse parameters to achieve clinically acceptable ablation sizes using a bipolar probe with while reducing the overall risk of arcing or system failure. 1. A medical device for ablating tissue cells in a treatment region by irreversible electroporation without thermally damaging the tissue cells , comprising:a temperature: controlled perfusate;an electrode probe having a perfusate channel for receiving the temperature controlling perfusate and at least two electrodes adapted to apply irreversible electroporation (IRE) pulses to the tissue cells in the treatment region;a control device for controlling the IRE pulses to the at least two electrodes and operable to provide the temperature controlling perfusate to the perfusate channel of the probe to maintain the temperature of the tissue cells between 20 degrees Celsius and 50 degrees Celsius.2. The medical device of claim 1 , wherein the temperature controlling perfusate controls an electrical conductivity rise in the tissue cells sufficiently to eliminate electrical arcing claim 1 , but without significantly altering the electric field distribution in the treatment zone.3. The medical device of claim 1 , wherein the control device provides the temperature controlling perfusate to the perfusate channel to maintain the temperature of the tissue cells at between 30 degrees Celsius and 45 degrees Celsius.4. The medical device of claim 1 , wherein the electrode probe includes a temperature sensor that measures the temperature of the tissue cells and the control circuit adjusts ...

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Номер записи: 62

07-03-2019 дата публикации

IMMUNOTHERAPEUTIC METHODS USING IRREVERSIBLE ELECTROPORATION

Номер: US20190069945A1

Автор: Davalos Rafael V., Garcia Paulo A., Rossmeisl John H.

Принадлежит:

Methods for treating tissue with irreversible electroporation and immunotherapy are described. The methods include placing a probe in tissue within a human body, wherein the probe has at least a first electrode, applying a plurality of electrical pulses through the first electrode and a second electrode, causing irreversible electroporation (IRE) of the tissue within a target ablation zone, and administering one or more exogenous agents into the tissue within the target ablation zone or to the human, thereby stimulating or otherwise modulating an immune system response within the body. 120-. (canceled)21. A method for treating tissue comprising:placing a probe in tissue within a human body, wherein the probe has at least a first electrode;applying a plurality of monophasic electrical pulses through the first electrode and a second electrode, wherein the monophasic electrical pulses have a pulse length of between 10 microseconds-100 microseconds; andcausing irreversible electroporation (IRE) of cells of the tissue within a first zone, and in an amount sufficient to promote an immune response by way of immune cells that respond to tissue injury resulting from the IRE.22. The method of claim 21 , wherein the monophasic electrical pulses are applied such that there is a delay between two adjacent pulses and create a voltage gradient of at least 500 v/cm.23. The method of claim 21 , wherein the monophasic electrical pulses are applied as a pulse train comprising bursts of pulses with a delay between one or more bursts.24. The method of claim 21 , wherein the immune response is promoted by immune cells present in the first zone claim 21 , which is a target ablation zone.25. The method of claim 21 , wherein the immune response is promoted by immune cells present in a second zone claim 21 , wherein the second zone is disposed beyond the first zone.26. The method of claim 21 , wherein the immune response is promoted by immune cells present in the first zone and a second zone ...

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Номер записи: 63

07-03-2019 дата публикации

SYSTEMS, DEVICES, AND METHODS FOR FOCAL ABLATION

Номер: US20190069950A1

Автор: LONG Gary, PAGEARD Jean-Luc, VISWANATHAN Raju, ZINGELER Allan

Принадлежит: Farapulse, Inc.

Systems, devices, and methods for electroporation ablation therapy are disclosed, with the device including a set of splines coupled to a catheter for medical ablation therapy. Each spline of the set of splines may include a set of electrodes formed on that spline. The set of splines may be configured for translation to transition between a first configuration and a second configuration. 186.-. (canceled)87. An apparatus , comprising:a catheter defining a longitudinal axis;a distal portion;a plurality of electrodes; a set of electrodes from the plurality of electrodes formed on that spline, each set of electrodes including (1) a distal electrode such that the set of splines includes a set of distal electrodes and (2) a proximal electrode such that the set of splines includes a set of proximal electrodes;', 'a proximal end coupled to a distal end of the catheter, the distal end coupled to the distal portion;, 'a set of splines, each spline of the set of splines including a first configuration in which the set of splines are approximately parallel to the longitudinal axis; and', 'a second configuration in which a distal portion of each spline of the set of splines is bowed radially outward from the longitudinal axis., 'the set of splines configured for translation along the longitudinal axis to transition between88. The apparatus of claim 87 , wherein the distal electrode and the proximal electrode formed on each spline from the set of splines are configured to be activated with opposite electrical polarities to generate energy for ablating tissue.89. The apparatus of claim 88 , wherein the set of distal electrodes are collectively configured as an anode and the set of proximal electrodes are collectively configured as a cathode claim 88 , to act as an anode-cathode pair for generating the energy for ablating tissue.90. The apparatus of claim 87 , wherein claim 87 , when the set of splines are in the second configuration claim 87 , at least one electrode from the set ...

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Номер записи: 64

16-03-2017 дата публикации

Surgical system for connecting body tissue

Номер: US20170071666A1

Автор: Anton Keller, Christoph Rothweiler, Dieter Weisshaupt

Принадлежит: Aesculap AG

A surgical system for connecting body tissue is provided. The surgical system includes a surgical instrument having two tool elements movable relative to each other, each of which comprises a high-frequency electrode. The high-frequency electrodes, in an approach position of the tool elements, define a minimum distance from each other, lying opposite each other and facing each other. The instrument has a shaft at the distal end of which at least a first one of the tool elements is arranged or formed. A second tool element is movable from an operating position, in which it is adapted for movement into the approach position, into a removal position and/or vice versa. A surface area of a perpendicular projection of the second tool element onto a projection plane extending perpendicularly to a shaft direction in a region of the second tool element is smaller in the removal position than in the operating position.

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Номер записи: 65

05-03-2020 дата публикации

Ablation catheters

Номер: US20200069364A1

Автор: Amr Salahieh, Brian D. Brandt, Emma LEPAK, John P. Claude, Jonah Lepak, Tom Saul

Принадлежит: Individual

Cardiac tissue ablation catheters including an inflatable and flexible toroidal or spherically shaped balloon disposed at a distal region of an elongate member, a flexible circuit carried by an outer surface of the balloon, the flexible circuit including, a plurality of flexible branches conforming to the radially outer surface of the balloon, each of the plurality of flexible branches including a substrate, a conductive trace carried by the substrate, and an ablation electrode carried by the substrate, the ablation electrode in electrical communication with the conductive trace, and an elongate shaft comprising a guidewire lumen extending in the elongate member and extending from a proximal region of the inflatable balloon to distal region of the inflatable balloon and being disposed within the inflatable balloon, wherein a distal region of the elongate shaft is secured directly or indirectly to the distal region of the inflatable balloon.

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Номер записи: 66

05-03-2020 дата публикации

Tissue Joiner

Номер: US20200069369A1

Автор: Tohru Tani

Принадлежит: Micron Shiga Inc

Developed is a tissue joining device for endoscopic surgery, which can be used in NOTES, or the like. As a result of intensive studies carried out to solve the problem described above, the inventors of the present invention have conceived of two tissue joining device having quite novel structures and completed the present invention.

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Номер записи: 67

19-03-2015 дата публикации

Electrosurgical (rf) medical instruments for cutting and coagulating tissue

Номер: US20150080891A1

Автор: Barry C. Worrell, Chester O. Baxter, III, David C. Yates, Frederick E. Shelton, IV, Geoffrey S. Strobl, Jennifer M. Mallow, John V. Hunt, Kevin L. Houser, Taylor W. Aronhalt

Принадлежит: Ethicon Endo Surgery Inc

An electrosurgical device is disclosed. The electrosurgical device includes a handle, a shaft extending distally from the handle, and an end effector coupled to a distal end of the shaft. The end effector comprises a first electrode and a second electrode. The second electrode includes a first position and a second position. The second electrode is configured to move from the first position to the second position when a force is applied to the end effector by a tissue section. The first electrode and the second electrode define a treatment area when the second electrode is in the second position.

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Номер записи: 68

05-06-2014 дата публикации

Method of destroying tissue cells by electroporation

Номер: US20140155977A1

Автор: Ali Jaafar, Victor Chornenky

Принадлежит: Angiodynamics Inc

An apparatus and method for performing non-invasive treatment of the human face and body by electroporation in lieu of cosmetic surgery is provided. The apparatus comprises a high voltage pulse generator and an applicator having two or more electrodes in close mechanical and electrical contact with the patient's skin for applying the pulses to the patient's skin. The applicator may consist of two pieces with one electrode having a sharp tip and another having a flat surface. High voltage pulses delivered to the electrodes create at the tip of the sharp electrode an electric field high enough to cause death of relatively large subcutaneous fat cells by electroporation. Moving the electrode tip along the skin creates a line of necrotic subcutaneous fat cells, which later are metabolized by the body. Multiple applications of the electrode along predetermined lines on the face or neck create shrinkage of the skin and the subcutaneous fat volume underlying the treated area.

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Номер записи: 69

22-03-2018 дата публикации

ELECTROSURGICAL SYSTEM WITH SELECTIVE CONTROL OF ACTIVE AND RETURN ELECTRODES

Номер: US20180078302A1

Автор: Cadouri Hadar, Tetzlaff Philip M.

Принадлежит:

Electrosurgical system with selective control of active and return electrodes. At least some of the illustrative embodiments are systems comprising an electrosurgical wand and an electrosurgical controller. The wand comprises a non-conductive outer surface, at least three electrodes disposed on a distal end of the wand, and at least three electrical leads extending from a proximal end of the wand (one electrical lead electrically coupled to each electrode). The controller comprises a voltage generator and a control circuit coupled between the voltage generator and the electrodes of the wand. The control circuit is configured to: selectively electrically couple the active terminal singly and in combination to the electrodes of the wand; and selectively electrically couple the return terminal singly and in combination to electrodes of the wand. 1. A system comprising:an electrosurgical wand having a non-conductive support member and at least three electrodes, each of the at least electrodes having an individual electrical lead electrically coupled thereto, the electrical leads extending to a proximal end of the wand; and wherein a first electrode of the at least three electrodes protrudes from the end of the non-conductive support member, and at least a second and third electrode of the at least three electrodes are disposed on a side surface of the non-conductive support member; and a controller connector coupled to the electrical leads;', 'a voltage generator configured to generate voltage of varying amplitude, the voltage generator having an active terminal and a return terminal; and', 'a control circuit coupled between the controller connector and the voltage generator;', 'the control circuit configured to selectively electrically couple both the active terminal singly or in combination to any of the at least three electrodes and selectively electrically couple the return terminal singly or in combination to any remaining electrodes of the at least three ...

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Номер записи: 70

22-03-2018 дата публикации

Methods and Apparatus for Bilateral Renal Neuromodulation

Номер: US20180078758A1

Автор: Deem Mark, Gelfand Mark, GIFFORD, III Hanson, Levin Howard R., Sutton Douglas, Zarins Denise

Принадлежит:

Methods and apparatus are provided for bilateral renal neuromodulation, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney. 154-. (canceled)55. A method for treatment of a hypertensive human patient , the method comprising:intravascularly positioning a catheter within a first renal artery associated with a first kidney of the patient;ablating renal nerves along the first renal artery via first ultrasound energy from the catheter;intravascularly positioning the catheter within a second renal artery associated with a second kidney of the patient; andablating renal nerves along the second renal artery via second ultrasound energy from the catheter,wherein ablating renal nerves along the first renal artery and ablating renal nerves along the second renal artery results in a therapeutically beneficial reduction in blood pressure of the hypertensive patient.56. The method of claim 55 , further comprising removing the catheter from the patient after delivering the first and second ultrasound energy to conclude the procedure.57. The method of wherein the first ultrasound energy is the same as the second ultrasound energy.58. The method of wherein the first ultrasound energy and ...

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Номер записи: 71

31-03-2022 дата публикации

PRETREATMENT WAVEFORM FOR IRREVERSIBLE ELECTROPORATION

Номер: US20220096151A1

Автор: Shuros Allan Charles

Принадлежит:

An electroporation ablation system for treating targeted tissue in a patient. The electroporation ablation system including an ablation catheter and an electroporation generator. The ablation catheter including a handle, a shaft having a distal end, and catheter electrodes situated at the distal end of the shaft and spatially arranged to generate electric fields in the targeted tissue in response to electrical pulses. The electroporation generator operatively coupled to the catheter electrodes and configured to deliver the electrical pulses in an irreversible electroporation pulse sequence that includes a preconditioning pulse sequence and an electroporation pulse sequence to one or more catheter electrodes. Wherein the preconditioning pulse sequence includes preconditioning electrical pulses configured to cause electrolysis near the targeted tissue and tetanizing skeletal muscle stimulation in the patient. 1. An electroporation ablation system for treating targeted tissue in a patient , the electroporation ablation system comprising: a handle;', 'a shaft having a distal end; and', 'catheter electrodes situated at the distal end of the shaft and spatially arranged to generate electric fields in the targeted tissue in response to electrical pulses; and, 'an ablation catheter includingan electroporation generator operatively coupled to the catheter electrodes and configured to deliver the electrical pulses in an irreversible electroporation pulse sequence that includes a preconditioning pulse sequence and an electroporation pulse sequence to one or more catheter electrodes,wherein the preconditioning pulse sequence includes preconditioning electrical pulses configured to cause electrolysis near the targeted tissue and tetanizing skeletal muscle stimulation in the patient.2. The electroporation ablation system of claim 1 , comprising a surface patch electrode attached to the patient and configured to generate electric fields in the patient in response to the electrical ...

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Номер записи: 72

12-03-2020 дата публикации

Method for controlling a modular energy system user interface

Номер: US20200078106A1

Автор: Andrew W. CARROLL, Eitan T. Wiener, Gregory J. Bakos, James M. Vachon, Jeffrey L. Aldridge, Joshua Henderson, Joshua P. Morgan

Принадлежит: Ethicon LLC

A method for controlling a user interface of a modular energy system. The modular energy system comprises a header module and a display screen on which the user interface is displayed. The modular energy system can detect attachment of a first module thereto, control the user interface to display one or more first user interface elements corresponding to the first module, detect attachment of a second module to the modular energy system, control the user interface to resize the one or more first user interface elements to accommodate display of one or more second user interface elements corresponding to the second module, and control the user interface to display the one or more second user interface elements. The various UI elements can correspond to the particular module type that is being connected to the modular energy system.

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Номер записи: 73

12-03-2020 дата публикации

Energy module for drivig multiple energy modalities through a port

Номер: US20200078117A1

Автор: Andrew W. CARROLL, Eitan T. Wiener, James R. Hoch, Jeffrey L. Aldridge, John B. Schulte, John E. Hein, Joshua Henderson, Joshua P. Morgan, Ryan M. Asher

Принадлежит: Ethicon LLC, Plexus Corp

An energy module connectable to a surgical instrument is disclosed. The energy module can include a circuit, which can include a first amplifier and a second amplifier coupled to a port of the energy module to which a surgical instrument is connectable. The first amplifier can be configured to generate a first drive signal at a first frequency range and the second amplifier can be configured to generate a second drive signal at a second frequency range. The circuit can be configured to control the amplifiers to deliver the first drive signal, the second drive signal, and/or a combination of the first and second drive signals to a surgical instrument connected to the port.

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Номер записи: 74

12-03-2020 дата публикации

ULTRASONIC SURGICAL INSTRUMENT CLAMP ARM WITH SNAP-ON CLAMP PAD

Номер: US20200078610A1

Автор: Asher Ryan M., Boehm Laura A., Denzinger Kristen G., Dickerson Benjamin D., Grubbs Nathan D., Loch Collin J., Prenger Daniel J.

Принадлежит:

An apparatus for operating on tissue includes a body, a shaft assembly, and an end effector. The shaft assembly extends distally from the body and includes an acoustic waveguide. The waveguide is configured to acoustically couple with an ultrasonic transducer. The end effector includes an ultrasonic blade, a clamp arm, and a clamp pad. The blade is in acoustic communication with the waveguide. The clamp arm is configured to pivot about a first pivot point toward and away from the ultrasonic blade and includes a coupling feature. The clamp pad is selectively attachable to the blade to acoustically isolate the clamp arm from the ultrasonic blade. The coupling feature of the clamp arm is configured to provide a snap fit between the clamp pad and the clamp arm and thereby permit manipulation of the clamp pad for removal of the clamp pad from the clamp arm. 120-. (canceled)21. An ultrasonic instrument for operating on tissue , comprising: (i) a first body,', '(ii) a second body configured to translate relative to the first body,', '(iii) a first coupling feature associated with the first body,', '(iv) a second coupling feature associated with the second body such that the second coupling feature is configured to translate relative to the first coupling feature, and', '(v) an acoustic waveguide;, '(a) a shaft assembly, comprising(b) an ultrasonic blade extending distally from the acoustic waveguide, wherein the ultrasonic blade is in acoustic communication with the acoustic waveguide; and(c) a clamp arm assembly configured to rotate relative to the first body and the second body between a first rotational position and a second rotational position, wherein the clamp arm assembly comprises a first complementary coupling feature and a second complementary coupling feature, wherein the first complementary coupling feature and the second complementary coupling feature are respectively decoupled from the first coupling feature and the second coupling feature in the first ...

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Номер записи: 75

29-03-2018 дата публикации

Systems, devices, and methods for delivery of pulsed electric field ablative energy to endocardial tissue

Номер: US20180085160A1

Автор: Gary Long, Jean-Luc Pageard, Raju Viswanathan

Принадлежит: Farapulse Inc

Systems, devices, and methods for electroporation ablation therapy are disclosed, with the system including a pulse waveform signal generator for medical ablation therapy, and an endocardial ablation device includes at least one electrode for ablation pulse delivery to tissue. The signal generator may deliver voltage pulses to the ablation device in the form of a pulse waveform. The system may include a cardiac stimulator for generation of pacing signals and for sequenced delivery of pulse waveforms in synchrony with the pacing signal.

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Номер записи: 76

21-03-2019 дата публикации

Techniques for Controlling an Irreversible Electroporation System

Номер: US20190083169A1

Автор: II Robert E., Neal, Single Gordon, Warden David

Принадлежит: ANGIODYNAMICS, INC.

An improved user interface system for an irreversible electroporation (IRE) system is provided. User interfaces are provided that dynamically display information provided by an operator or provided by the IRE system during setup, planning, and implementation stages of an IRE procedure in a more intuitive and efficient manner. As a result of being provided the user interfaces described herein, operators can plan and implement more effective IRE procedures to the benefit of a patient. 1. An irreversible electroporation (IRE) system , comprising:a processor operable with a memory and a display device;one or more input devices;an input signal receiver operable on the processor to receive one or more input signals from the one or more input devices; and a pulse parameters table for textual display of numerical values indicating a voltage, a pulse length, a number of pulses, and a distance for an active probe pair of a user selected probe array, the pulse parameter table further indicating a polarity of the active probe pair; and', 'a probe placement grid for graphical display of the user selected probe array in relation to a lesion zone and a target ablation zone, each probe of the user selected probe array comprising a probe grid icon and a probe number, the active probe pair of the user selected probe array indicated by a dashed line connecting the probe grid icons of the active probe pair, the polarity of the active probe pair indicated by an arrow of the dashed line pointing to a negative probe of the active probe pair, the distance between the active probe pair indicated by a distance value positioned over the dashed line and by a spacing between the probe grid icons of the active probe pair., 'a display controller operable on the processor to receive input information from the input signal receiver and to retrieve user interface information from the memory based upon the input information for display of a user interface on the display device, the user interface ...

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Номер записи: 77

05-05-2022 дата публикации

Profile parameter selection algorithm for electroporation

Номер: US20220133389A1

Автор: Brian T. HOWARD, John Vandanacker, Mark T. Stewart, Steven J. Fraasch

Принадлежит: MEDTRONIC INC

A method of determining a pulsed field ablation waveform parameter for creating a desired lesion characteristic in cardiac tissue. The method of provides an electrosurgical generator configured to deliver electroporation pulses, the generator configured to: load predetermined waveform parameters (y i ); load predetermined modeling data (x i ); accept entry of a user inputted desired lesion characteristic (u i ); and determine at least one corresponding pulsed field ablation waveform parameter based on (u i ), (y i ); and (x i ).

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Номер записи: 78

05-05-2022 дата публикации

Systems and methods for ablation using non-adjacent bipoles

Номер: US20220133403A1

Автор: Boyce Moon, Eric Olson

Принадлежит: St Jude Medical Cardiology Division Inc

Systems and methods for ablating tissue are provided. An ablation system includes a catheter having a plurality of electrodes, and a controller coupled to the catheter. The controller is configured to select at least one pair of non-adjacent electrodes of the plurality of electrodes, and sequentially apply bipolar stimulation using the at least one selected pair of non-adjacent electrodes.

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Номер записи: 79

05-05-2022 дата публикации

Method and apparatus for rapid and selective transurethral tissue ablation

Номер: US20220133405A1

Автор: Steven R. MICKELSEN

Принадлежит: Boston Scientific Scimed Inc, Farapulse Inc

Catheter systems, tools and methods are disclosed for the selective and rapid application of DC voltage pulses to drive irreversible electroporation for minimally invasive transurethral prostate ablation. In one embodiment, a switch unit is used to modulate and apply voltage pulses from a cardiac defibrillator, while in another, the system controller can be configured to apply voltages to an independently selected multiplicity or subsets of electrodes. Devices are disclosed for more effective DC voltage application including the infusion of cooled fluid to elevate the irreversible electroporation threshold of urethral wall tissue and to selectively ablate regions of prostate tissue alone.

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Номер записи: 80

05-04-2018 дата публикации

CATHETERS, CATHETER SYSTEMS, AND METHODS FOR PUNCTURING THROUGH A TISSUE STRUCTURE AND ABLATING A TISSUE REGION

Номер: US20180093088A1

Автор: Mickelsen Steven Richard

Принадлежит:

A percutaneous catheter system for use within the human body and an ablation catheter for ablating a selected tissue region within the body of a subject. The percutaneous catheter system can include two catheters that are operatively coupled to one another by magnetic coupling through a tissue structure. The ablation catheter can include electrodes positioned within a central portion. The ablation catheter is positioned such that the central portion of a flexible shaft at least partially surrounds the selected tissue region. Each electrode of the ablation catheter can be activated independently to apply ablative energy to the selected tissue region. The ablation catheter can employ high impedance structures to change the current density at specific points. Methods of puncturing through a tissue structure using the percutaneous catheter system are disclosed. Also disclosed are methods for ablating a selected tissue region using the ablation catheter. 1. A method , comprising:positioning a catheter external to a heart of a subject, such that a central portion of the catheter at least partially encircles the left pulmonary veins and the right pulmonary veins of the heart, the central portion of the catheter including a set of electrodes; anddelivering electrical energy to at least a portion of the left atrium of the heart using two or more electrodes of the set of electrodes, the portion of the left atrium including: a first wall portion of the left atrium; the endocardial space of the left atrium; and a second wall portion of the left atrium.2. The method of claim 1 , the delivering the electrical energy including ablating tissue in the first wall portion and the second wall portion of the left atrium to create a lesion.3. The method of claim 1 , the delivering the electrical energy including ablating tissue in the portion of the left atrium to create a circumferential lesion in the wall of the left atrium without repositioning the catheter.4. The method of claim 1 , ...

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Номер записи: 81

28-03-2019 дата публикации

MEDICAL INSTRUMENT ELECTRICALLY ENERGIZED USING DRIVE CABLES

Номер: US20190090940A1

Автор: Burbank William A., Gresham Richard D., MANZO Scott E.

Принадлежит: INTUITIVE SURGICAL OPERATIONS, INC.

An electrically energized medical instrument uses one or more drive cables to both actuate mechanical components of a wrist mechanism or an effector and to electrically energize the effector. Electrical isolation can be achieved using an insulating main tube through which drive cables extend from a backend mechanism to the effector, an insulating end cover that leaves only the desired portions of the effector exposed, and one or more seals to prevent electrically conductive liquid from entering the main tube. Component count and cost may be further reduced using a pair of pulleys that are shared by four drive cables. 1. A medical instrument , comprising:a main tube comprising a proximal end and a distal end;an effector comprising a first portion and a second portion, the effector being movably coupled to the distal end of the main tube, and the first portion of the effector comprising an electrically conductive component;a first cable having a proximal end portion and a distal end portion, the first cable extending through the main tube, the distal end portion of the first cable being coupled to the first portion of the effector, the first cable being electrically conductive, and an electrically conductive path being established between the first cable and the electrically conductive component;a second cable having a proximal end portion and a distal end portion, the second cable extending through the main tube, and the distal end portion of the second cable being coupled to the second portion of the effector; anda backend mechanism comprising a transmission and an electrical system, the backend mechanism being coupled to the proximal end of the main tube, the proximal end portion of the first cable and the proximal end portion of the second cable both being coupled to the transmission, the transmission being operable to actuate the effector via the first cable and the second cable, the electrical system being electrically coupled to at least the proximal end ...

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Номер записи: 82

28-03-2019 дата публикации

Methods and apparatus for intravascularly-induced neuromodulation

Номер: US20190090943A1

Автор: Benjamin J. Clark, Denise Zarins, Erik Thai, Nicolas Zadno

Принадлежит: Medtronic Ardian Luxembourg SARL

Methods and apparatus are provided for intravascularly-induced neuromodulation using a pulsed electric field, e.g., to effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, changes in cytokine upregulation, etc., in target neural fibers. In some embodiments, the intravascular PEF system comprises a catheter having a pair of bipolar electrodes for delivering the PEF, with a first electrode positioned on a first side of an impedance-altering element and a second electrode positioned on an opposing side of the impedance-altering element. A length of the electrodes, as well as a separation distance between the first and second electrodes, may be specified such that, with the impedance-altering element deployed in a manner that locally increases impedance within a patient's vessel, e.g., with the impedance-altering element deployed into contact with the vessel wall at a treatment site within the patient's vasculature, a magnitude of applied voltage delivered across the bipolar electrodes necessary to achieve desired neuromodulation is reduced relative to an intravascular PEF system having similarly spaced electrodes but no (or an undeployed) impedance-altering element. In a preferred embodiment, the impedance-altering element comprises an inflatable balloon configured to locally increase impedance within a patient's vasculature. The methods and apparatus of the present invention may be used to modulate a neural fiber that contributes to renal function.

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Номер записи: 83

28-03-2019 дата публикации

Methods and Apparatus for Monopolar Renal Neuromodulation

Номер: US20190090944A1

Автор: Denise Zarins, Hanson Gifford, III, Howard R. Levin, Mark Deem, Mark Gelfand, Nicolas Zadno

Принадлежит: Medtronic Ardian Luxembourg SARL

Methods and apparatus are provided for monopolar neuromodulation, e.g., via a pulsed electric field. Such monopolar neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, monopolar neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such monopolar neuromodulation is performed bilaterally.

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Номер записи: 84

26-03-2020 дата публикации

METHODS OF REDUCING ADVERSE EFFECTS OF NON-THERMAL ABLATION

Номер: US20200093541A9

Автор: Davalos Rafael V., Garcia Paulo A., II Robert E., Neal, Robertson John L., Rossmeisl John H.

Принадлежит:

The present invention provides systems, methods, and devices for electroporation-based therapies (EBTs). Embodiments provide patient-specific treatment protocols derived by the numerical modeling of 3D reconstructions of target tissue from images taken of the tissue, and optionally accounting for one or more of physical constraints or dynamic tissue properties. The present invention further relates to systems, methods, and devices for delivering bipolar electric pulses for irreversible electroporation exhibiting reduced or no damage to tissue typically associated with an EBT-induced excessive charge delivered to the tissue. 117-. (canceled)18. A method of reducing adverse effects of irreversible electroporation comprising administering electrical pulses through electrodes to tissue in a manner which causes irreversible electroporation of the tissue but minimizes electrical charge build up on the electrodes , or minimizes charge delivered to the tissue , or both.19. The method of claim 18 , wherein the adverse effects are one or more of thermal damage of the tissue claim 18 , electrochemical effects claim 18 , or electrolysis.20. The method of claim 19 , wherein the electrical pulses comprise a series of unipolar or bipolar pulses with a net charge of zero.21. The method of claim 20 , wherein the net charge of zero is achieved by a change in potential direction between each pulse claim 20 , or a change in potential direction within each pulse.22. The method of claim 20 , wherein the electrical pulses together comprise a pulse protocol comprising a train of unipolar pulses followed by a train of unipolar pulses of opposite polarity claim 20 , or a train of bipolar pulses claim 20 , or simultaneous unipolar pulses of opposite polarity claim 20 , or simultaneous unipolar pulses of opposite polarity which are offset from one another by a desired amount claim 20 , or a combination of protocols.23. The method of claim 22 , wherein the electrical pulses have a waveform ...

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Номер записи: 85

04-04-2019 дата публикации

CONTROLLED IRREVERSIBLE ELECTROPORATION

Номер: US20190099214A1

Автор: Daniels Charlotte, Rubinsky Boris

Принадлежит:

Electrical pulses are applied to tissue in a manner which destroys targeted cells such as cancerous cells while sparing non-targeted cells such as nerve cells. The electrical pulses are controlled within ranges for voltage, wattage and duration of application. Multiple pulses or groups of pulses may be applied to obtain a desired result while maintaining any temperature increase below a level which destroys cells. 120.-. (canceled)21. A method comprising the steps of:identifying cells to be ablated in a target area, wherein the target area comprises heterogenous tissue comprising nerve tissue surrounded by myelin layers;selecting a size, shape, or relative position of a first electrode and a second electrode;placing the first electrode and the second electrode in the target area; andapplying electrical pulses between the first electrode and the second electrode in an amount which compensates for tissue heterogeneity, and is sufficient to irreversibly electroporate the cells in the target area; wherein voltage, wattage and duration of the electrical pulses are maintained within ranges which avoid thermal damage to nerve tissue and the cells in the target area.22. The method of claim 21 , wherein the myelin layers insulate the nerve tissue from thermal damage.23. The method of claim 21 , further comprising:monitoring temperature of the heterogeneous tissue and adjusting the electrical pulses to maintain the temperature at 50° C. or less for a period of time that avoids thermal damage to cells of the heterogeneous tissue.24. The method of claim 21 , further comprising:infusing a material into the heterogenous tissue prior to applying the electrical pulses.25. The method of claim 24 , wherein the material is a chemotherapeutic agent.26. The method of claim 24 , wherein the material is an imaging agent.27. The method of claim 21 , wherein the first electrode and the second electrode are substantially circular in shape; andwherein the first and second electrodes are ...

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Номер записи: 86

02-06-2022 дата публикации

INTRACARDIAC TOOLS AND METHODS FOR DELIVERY OF ELECTROPORATION THERAPIES

Номер: US20220168043A1

Автор: HONECK Jordon D., STEWART Mark T.

Принадлежит:

A medical device comprising an elongate body having a proximal portion, a distal portion, a distal end, a longitudinal axis, and a radius, a plurality of deployable arms, the deployable arms being movably coupled to the elongate body, and at least one arm from the plurality of deployable arms having at least one electrically conductive surface. The plurality of deployable arms being movable from a collapsed configuration to an expanded configuration. In the collapsed configuration, the plurality of deployable arms are approximately parallel to the longitudinal axis. In the expanded configuration, the at least one electrically conductive surface is distal facing and is positioned radially from the longitudinal axis by a distance that is greater than the radius of the elongate body. 1. A medical device comprising:an elongate body having a proximal portion, a distal portion, a distal end, a longitudinal axis, and a radius;a plurality of deployable arms, the deployable arms being movably coupled to the elongate body; andat least one arm from the plurality of deployable arms having at least one electrically conductive surface, the plurality of deployable arms being movable from a collapsed configuration to an expanded configuration, wherein in the collapsed configuration the plurality of deployable arms are approximately parallel to the longitudinal axis, and wherein in the expanded configuration the at least one electrically conductive surface is distal facing and is positioned radially from the longitudinal axis by a distance that is greater than the radius of the elongate body.2. The medical device of claim 1 , wherein the plurality of deployable arms comprises five deployable arms.3. The medical device of claim 1 , further comprising a shaft claim 1 , the shaft being at least partially disposed within a portion of the elongate body claim 1 , the shaft being slidably and rotatably moveable with respect to the elongate body.4. The medical device of claim 3 , wherein ...

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Номер записи: 87

20-04-2017 дата публикации

Apparatus and methods of inducing weight loss using blood flow control

Номер: US20170105860A1

Автор: Charles J. Bruce, Elizabeth Rajan, Gianrico Farrugia, Juliane Bingener-Casey, Louis-Michel Wong Kee Song, Michael J. Levy, Navtej S. Buttar, Paul A. Friedman, Samuel J. Asirvatham

Принадлежит: Mayo Foundation for Medical Education and Research

Methods and apparatus for inducing weight loss using blood flow control are described herein. The apparatus and methods operate by controlling blood flow to the stomach and/or small bowel.

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Номер записи: 88

03-07-2014 дата публикации

Methods, apparatus, and systems for tissue dissection and modification

Номер: US20140188111A1

Автор: Paul Joseph Weber

Принадлежит: TDM SURGITECH Inc

Methods, apparatus and systems for tissue dissection and modification are disclosed herein. A method for tissue dissection and modification may comprise inserting a tissue dissecting and modifying wand (TDM) through an incision in a patient's body. The TDM may comprise a tip having a plurality of protrusions with lysing segments positioned between the protrusions to dissect and/or modify tissue. The TDM may also comprise an energy window positioned on top of the TDM that is configured to deliver energy to modify tissues. After separating tissue using the lysing segment(s) to define a target region, the energy window may be activated and moved around within the target region to modify tissues. In some implementations, the energy window may be activated prior to and/or during dissection of the tissue such that the tissue is separated while tissue is modified within the target region.

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Номер записи: 89

29-04-2021 дата публикации

ELECTROPORATION SYSTEMS AND CATHETERS FOR ELECTROPORATION SYSTEMS

Номер: US20210121228A1

Автор: Byrd Israel

Принадлежит:

The present disclosure provides catheters for electroporation systems. One catheter includes a plurality of catheter electrodes disposed along a portion of a distal end of the electroporation catheter. The plurality of catheter electrodes includes a plurality of first type catheter electrodes adapted for use with an electroporation generator during an electroporation procedure and a plurality of second type catheter electrodes adapted for use with an electroporation generator during an electroporation procedure and for use with a diagnostic subsystem. The plurality of first type catheter electrodes is positioned at a distal end of the electroporation catheter. Each second type catheter electrode is adjacent another second type catheter electrode. 1. An electroporation catheter comprising: a plurality of first type catheter electrodes adapted for use with an electroporation generator during an electroporation procedure; and', 'a plurality of second type catheter electrodes adapted for use with an electroporation generator during an electroporation procedure and for use with a diagnostic subsystem, wherein each second type catheter electrode is adjacent another second type catheter electrode., 'a plurality of catheter electrodes disposed along a portion of a distal end of the electroporation catheter, the plurality of catheter electrodes comprising2. The electroporation catheter of claim 1 , wherein adjacent second type catheter electrodes form a pair of second type catheter electrodes claim 1 , and the first type catheter electrodes and pairs of second type catheter electrodes are alternately positioned along the portion of the electroporation catheter with every first type catheter electrode adjacent at least one pair of second type catheter electrodes.3. The electroporation catheter of claim 2 , wherein each pair of second type catheter electrodes is positioned between two first type catheter electrodes.4. The electroporation catheter of claim 1 , wherein each ...

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Номер записи: 90

11-04-2019 дата публикации

ELECTROSURGICAL SYSTEM

Номер: US20190105096A1

Автор: Albrecht Jeremy, Durant Dan, Elliott Patrick, Gorin Igor, Hudson Kevin, Jacobs Hank, JOHNSON GARY, Kowalski Gerald, Linville-Engler Benjamin, LOGAN Michael, Matthews Thomas, McFarland Daniel, Nguyen Duy, Sabarad Jagdish, Tiberia Lou, Whitlock Michael

Принадлежит:

An electrosurgical generator arranged to supply radio frequency (RF) energy to fuse tissue is provided. The generator is arranged to supply RF energy through a removably coupled electrosurgical instrument to fuse tissue grasped by the instrument. The generator monitors a phase angle of the supplied RF energy and adjusts or terminates the supplied RF energy based on the monitored phase angle in comparison to predetermined thresholds and conditions to optimally fuse the tissue. The electrosurgical instrument conducts radio frequency energy to fuse tissue captured between the jaws and a blade to mechanically cut tissue between the jaws. A conductive post positioned on the jaw adjacent to the blade 1. An electrosurgical system comprising:an electrosurgical instrument arranged to grasp and fuse tissue using radio frequency (RF) energy; andan electrosurgical generator connectable to the electrosurgical instrument and configured to supply the RF energy through the electrosurgical instrument, the generator comprising:an RF amplifier arranged to supply RF energy through the electrosurgical instrument in which voltage of the supplied RF energy is applied in a ramping fashion and subsequently held constant.2. The system of wherein the voltage of the supplied RF energy is held constant at a predetermined voltage.3. The system of further comprising a controller arranged to monitor a phase angle of the supplied RF energy claim 2 , the controller signals the RF amplifier to terminate the supply of RF energy when the monitored phase angle is less than a predefined phase value.4. The system of wherein the predefined phase value is less than zero degrees.5. The system of wherein the voltage of the supplied RF energy applied in a ramping fashion starts from a voltage being 25 percent of a predefined voltage setting to a voltage being 80 percent of the predefined voltage setting.6. The system of wherein the voltage of the supplied RF energy is held constant at its current voltage level ...

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Номер записи: 91

11-04-2019 дата публикации

SYSTEMS AND METHODS FOR OCULAR LASER SURGERY AND THERAPEUTIC TREATMENTS

Номер: US20190105200A1

Автор: Hipsley AnnMarie

Принадлежит:

Systems, devices and methods are provided to deliver microporation medical treatments to improve biomechanics, wherein the system includes a laser for generating a beam of laser radiation on a treatment-axis not aligned with a patient's visual-axis, operable for use in subsurface ablative medical treatments to create an array pattern of micropores that improves biomechanics. The array pattern of micropores is at least one of a radial pattern, a spiral pattern, a phyllotactic pattern, or an asymmetric pattern. 1. A system for delivering microporation medical treatments to improve biomechanics , the system comprising:a laser for generating a beam of laser radiation on a treatment-axis not aligned with a patient's visual-axis, operable for use in subsurface ablative medical treatments to create an array pattern of micropores that improves biomechanics;a housing;a controller within the housing, in communication with the laser and operable to control dosimetry of the beam of laser radiation in application to a target tissue;a lens operable to focus the beam of laser radiation onto a target tissue;an automated off-axis subsurface anatomy tracking, measuring, and avoidance system; andwherein the array pattern of micropores is at least one of a radial pattern, a spiral pattern, a phyllotactic pattern, or an asymmetric pattern.2. The system of claim 1 , wherein the array pattern of micropores is a spiral pattern of an Archimedean spiral claim 1 , a Euler spiral claim 1 , a Fermat's spiral claim 1 , a hyperbolic spiral claim 1 , a lituus claim 1 , a logarithmic spiral claim 1 , a Fibonacci spiral claim 1 , a golden spiral claim 1 , or combinations thereof.3. The system of claim 1 , wherein the array pattern of micropores has a controlled asymmetry.4. The system of claim 3 , wherein the controlled asymmetry is an at least partial rotational asymmetry about the center of the array pattern.5. The system of claim 1 , wherein the array pattern of micropores has a controlled ...

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Номер записи: 92

09-06-2022 дата публикации

Radio-frequency ablation and direct current electroporation catheters

Номер: US20220175445A1

Автор: Derek C. Sutermeister, Salome A. Gonzalez, Troy T. Tegg

Принадлежит: St Jude Medical Cardiology Division Inc

Aspects of the present disclosure are directed to flexible catheters for both electrophysiology mapping and ablation using a high-density array of electrodes. These catheters may be used to detect electrophysiological characteristics of tissue in contact with the electrodes, and conduct monopolar and bipolar ablations of the tissue.

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Номер записи: 93

26-04-2018 дата публикации

System and Method for Targeted Delivery of Therapeutic Agents to Tissue

Номер: US20180110964A1

Автор: Hammond Jeffrey, Weadock Kevin

Принадлежит:

Novel systems for and methods of delivering therapeutic agents to target tissues are disclosed. The method of delivering a therapeutic agent to a target tissue involves identifying a target tissue via an imaging modality and then using a guidewire capable of anchoring in tissue to advance a cannula to the target tissue. The guidewire and novel cannula configurations enable rapid and repeated treatments of the target tissue without the need for subsequent imaging. The cannula is coupled to a source of ultrasound, radiation, radiofrequency energy, or chemotherapeutic agents which can then be delivered to from the cannula the target tissue. The system and method can be used to treat tumors that are small or surgically inoperable. In addition, the system can be used to treat lymphatic tissue that may contain metastases from the tumors. 118-. (canceled)19. A method of treating tumor cells in lymphatic tissue , the method comprising;identifying a tumor via an imaging modality;providing a needle having a distal end and a proximal end and a lumen;inserting the needle into a patient so that its distal end is proximate a tumor;inserting a guidewire having a proximal end and a distal end through the lumen of the needle;advancing the guidewire in the lumen so that its distal end is positioned proximate the tumor;removing the needle from the patient;providing a cannula having a proximal end and a distal end and at least two lumens;inserting the proximal end of the guidewire into one of the lumens of the cannula and advancing the cannula over the guidewire until the distal end of the cannula is proximate the tumor but not within a blood vessel;coupling one of the lumens on the proximal end of the cannula to a source of therapeutic agent; and,delivering the therapeutic agent to the target tissue so as to enable local lymphatic vessels to absorb the therapeutic agent.2021-. (canceled)22. The method of claim 19 , wherein the imaging modality is selected from the group consisting of ...

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Номер записи: 94

09-04-2020 дата публикации

System and method for prostate treatment under local anesthesia

Номер: US20200108222A1

Автор: Fernando J. BIANCO

Принадлежит: Smartblate LLC

A system and method for prostate cancer treatment under local anesthesia includes creating a superficial skin and subcutaneous block in a perineal area of a patient by administering a first anesthetizing agent; creating a deep nerve block under ultrasound guidance by administering a second anesthetizing agent, the second anesthetizing agent infiltrating cavernosal nerve bundle tissue and periprostatic space; and ablating prostate tissue. The office-based method, statistical models and computer generated treatment plans identify and ablate prostate tissue containing cancer through or via the perineum while preserving prostate function, and critical anatomical structures. Multiple technologies are integrated and processed to deliver a safe treatment procedure, under local anesthesia by integrating the information of magnetic resonance imaging and planning the ablative treatment using algorithms that ensure maximal precision in both killing cancerous tissue and preserving healthy tissue along with its corresponding function.

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Номер записи: 95

03-05-2018 дата публикации

MEDICAL INSTRUMENT ELECTRICALLY ENERGIZED USING DRIVE CABLES

Номер: US20180116708A1

Автор: Burbank William A., Gresham Richard D., MANZO Scott E.

Принадлежит: INTUITIVE SURGICAL OPERATIONS, INC.

An electrically energized medical instrument uses one or more drive cables to both actuate mechanical components of a wrist mechanism or an effector and to electrically energize the effector. Electrical isolation can be achieved using an insulating main tube through which drive cables extend from a backend mechanism to the effector, an insulating end cover that leaves only the desired portions of the effector exposed, and one or more seals to prevent electrically conductive liquid from entering the main tube. Component count and cost may be further reduced using a pair of pulleys that are shared by four drive cables. 130.-. (canceled)31. An apparatus , comprising:a first link coupled to an instrument shaft;a second link having a proximal end portion and a distal end portion, the proximal end portion coupled to the first link, the second link rotatable relative to the first link about a first axis, the distal end portion of the second link coupled to a tool member, the tool member rotatable relative to the second link about a second axis;a pulley coupled to the second link and configured to rotate about the first axis; anda cable having a coupling portion coupled to the tool member, the tool member rotatable relative to the second link about the second axis when the cable is moved, the cable spaced apart from the pulley when the second link is in a first orientation relative to the first link, the cable wrapped about a portion of the pulley when the second link is in a second orientation relative to the first link.32. The apparatus of claim 31 , wherein the pulley rotates with the movement of the cable when the second link is in the second orientation relative to the first link.33. The apparatus of claim 31 , wherein the cable slides on a guide surface of the second link when the second link is in the first orientation relative to the first link to cause rotation of the tool member.34. The apparatus of claim 31 , wherein:the first link is a proximal clevis;the second ...

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Номер записи: 96

03-05-2018 дата публикации

Methods of Sterilization and Treating Infection Using Irreversible Electroporation

Номер: US20180116710A1

Автор: Pearson Robert

Принадлежит: ANGIODYNAMICS, INC.

A method for treating an infection using irreversible electroporation is presented. The method includes providing an ablation device that has at least one electrode and inserting the ablation device into a target tissue of a patient. The tissue at least partially surrounds the implanted medical device. The outer surface of the medical device is at least partially covered by infectious cells. The method also involves positioning at least one electrode in or near the implanted medical device and delivering electrical pulses to or near the implanted medical device sufficient to irreversibly electroporate the infectious cells. 1. A method of treating an infection in patient , wherein the method comprises:providing an ablation device, wherein the device comprises at least one electrode;inserting the ablation device into a target tissue of the patient, wherein the tissue at least partially surrounds an implanted medical device, and wherein the outer surface of the medical device is at least partially covered by infectious cells;positioning the at least one electrode in or near the implanted medical device; anddelivering electrical pulses to or near the implanted medical device sufficient to irreversibly electroporate the infectious cells.2. The method of claim 1 , wherein the implanted medical device is selected from the group comprising: a catheter claim 1 , an artificial cartilaginous implant claim 1 , a pacemaker claim 1 , an implantable port claim 1 , a stent claim 1 , orthopedic prosthetic claim 1 , PICC claim 1 , implantable valve claim 1 , spinal implant claim 1 , tooth implant claim 1 , and a filter.3Staphylococcus epidermidis, Escherichia coli, Staphylococcus aureus, Streptococcus Mutans, Streptococcus Mitus, Streptococcus SalivariusEnterobacter Aerogenes.. The method of claim 1 , wherein the infectious cells comprise bacterial cells selected from the group comprising bacteremia claim 1 , claim 1 , and4. A method of sterilizing an infected implanted medical ...

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Номер записи: 97

07-05-2015 дата публикации

Ocular cross-linking system and method for sealing corneal wounds

Номер: US20150126921A1

Автор: Raymond A. Hartman, Roy S. Rubinfeld, Sandy T. Feldman

Принадлежит: CXL Ophthalmics LLC

Wounds in the eye following surgery or injury are sealed by soaking the area with a riboflavin solution containing iodide ion and irradiating the wound area with UVA radiation in a selected wavelength range for a selected time period to promote cross-linking of tissue between opposite surfaces of the wound or between the incised wound surfaces and a graft or implant.

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Номер записи: 98

07-05-2015 дата публикации

Coaxial dual function probe and method of use

Номер: US20150126922A1

Автор: Jeffrey R. Willis

Принадлежит: Angiodynamics Inc

An energy delivery probe for use in tissue ablation and method of use is presented. The energy delivery device has at least a first energy delivery member and a second energy delivery member that have handle members positioned along a longitudinal axis, each handle member having a proximal and distal end. The distal end of the first handle member is releasably coupled to the proximal end of the second handle member and a portion of each member is defined in a coaxially surrounding relationship to each other along the longitudinal axis. The method of using the probe involves identifying a tissue to be ablated, providing the energy delivery probe, inserting at least a portion of the energy delivery probe into the identified tissue, delivering electrical energy through the energy delivery probe to the identified tissue, and ablating the identified tissue such that at least a first ablation zone is formed.

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Номер записи: 99

10-05-2018 дата публикации

IRREVERSIBLE ELECTROPORATION USING TISSUE VASCULATURE TO TREAT ABERRANT CELL MASSES OR CREATE TISSUE SCAFFOLDS

Номер: US20180125565A1

Автор: Davalos Rafael V., Garcia Paulo A., Neal Robert E., Robertson John L., Sano Michael B.

Принадлежит:

The present invention relates to the field of medical treatment of diseases and disorders, as well as the field of biomedical engineering. Embodiments of the invention relate to the delivery of Irreversible Electroporation (IRE) through the vasculature of organs to treat tumors embedded deep within the tissue or organ, or to decellularize organs to produce a scaffold from existing animal tissue with the existing vasculature intact. In particular, methods of administering non-thermal irreversible electroporation (IRE) in vivo are provided for the treatment of tumors located in vascularized tissues and organs. Embodiments of the invention further provide scaffolds and tissues from natural sources created using IRE ex vivo to remove cellular debris, maximize recellularization potential, and minimize foreign body immune response. The engineered tissues can be used in methods of treating subjects, such as those in need of tissue replacement or augmentation. 12-. (canceled)3. A device for ablating target tissue cells comprising:a first electrode adapted for insertion into a blood vessel associated with the target tissue cells and adapted to be in contact with fluid inside the blood vessel; anda voltage source adapted to apply a plurality of electrical pulses to the first electrode so as to deliver ablation energy to the target tissue cells using the fluid inside the blood vessel as an electrical conduit.4. The device of claim 3 , wherein the voltage source is adapted to generate the plurality of electrical pulses in an amount sufficient to ablate the target tissue cells by irreversible electroporation (IRE).5. The device of claim 3 , wherein the voltage source is adapted to generate the plurality of radio frequency (RF) pulses in an amount sufficient to thermally ablate the target tissue cells.6. The device of claim 3 , wherein the first electrode is a wire electrode having an exposed portion adapted to be in contact with the fluid inside the blood vessel.7. The device of ...

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Номер записи: 100