ИЗМЕРЕНИЕ ТЕМПЕРАТУРЫ МОЧЕВОГО ПУЗЫРЯ ДЛЯ ВЫСОКОИНТЕНСИВНОГО СФОКУСИРОВАННОГО УЛЬТРАЗВУКА

FIELD: medicine.SUBSTANCE: group of inventions relates to medical equipment, namely to body temperature measurement means when performing high-intensity focused ultrasonic action. Medical instrument comprises high-intensity focused ultrasonic system for ultrasonic action on target area inside subject, light source for excitation of heat-sensitive fluorescent dye, wherein the light source is configured to be connected to the urinary catheter fiber optic cable, a light sensor for measuring fluorescence emitted by the heat-sensitive fluorescent dye, wherein the light sensor is configured to be connected to the fiber optic cable, the fluorescent dye container and the pumping system configured to be connected to the urinary catheter, wherein the pumping system is further connected to the fluorescent dye container and is configured to be pumped from the fluorescent dye container to the distal end of the urinary catheter, memory for storing computer-executable instructions and a processor for managing the medical instrument, wherein execution of computer-executable instructions causes processor to receive ultrasound exposure plan to target area, measure fluorescence using light sensor, calculating bladder temperature using fluorescence, and generating ultrasonic exposure commands using an ultrasound exposure plan and urinary bladder temperature, wherein the ultrasonic action commands are intended to control a high-intensity focused ultrasonic system for ultrasonic action on the target area. Device is equipped with a machine-readable carrier storing a computer program product containing computer-executable instructions for execution by a processor controlling a medical instrument.EFFECT: use of inventions makes it possible to increase efficiency of body temperature measurement, which is compatible with HIFU.13 cl, 9 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 686 294 C1 (51) МПК A61N 7/02 (2006.01) G01K 11/32 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ ( ...

СПОСОБ И СИСТЕМЫ ДЛЯ ФОРМИРОВАНИЯ ИЗОБРАЖЕНИЙ В КОГЕРЕНТНОМ ИЗЛУЧЕНИИ И УПРАВЛЕНИЯ С ОБРАТНОЙ СВЯЗЬЮ ДЛЯ МОДИФИКАЦИИ МАТЕРИАЛОВ

Suction stabilized epicardial ablation devices

Method and apparatus for treating soft tissue injury

An apparatus for the treatment of a soft tissue injury (eg a soft tissue injury that may be the cause, or contributes to, acute or chronic pain such. as sciatica) comprising; a thermal imaging arrangement to scan, a least a portion of a patient to provide a thermal image; a processing arrangement to review the thermal image to determine a point or region of thermal anomaly on the patient; a laser treatment device to provide a laser beam (eg for low-level laser treatment); and a guidance arrangement for the laser treatment device to guide the laser beam to the point or region of thermal anomaly on the patient as determined by the processing arrangement; to thereby treat the patient.

Compositions and methods for targeted thermomodulation

COMPOSITIONS AND METHODS FOR TARGETED THERMOMODULATION Provided are nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans.

PHOTO-THERMAL TARGETED TREATMENT SYSTEM WITH INTEGRATED PRE-CONDITIONING, AND AUTOMATIC TRIGGERING OF PHOTO-THERMAL TARGETED TREATMENT VIA MEASUREMENT OF SKIN SURFACE TEMPERATURE AND ASSOCIATED METHODS

A photo-thermal targeted treatment system for damaging a target embedded in a medium includes a controller and a photo -thermal treatment unit including a light source. The controller is configured for administering a treatment protocol using the light source at a preset power setting and a preset pulse timing setting. Also, a method for automatically initiating a treatment protocol using a photo -thermal targeted treatment system includes administering a cooling mechanism at a treatment location, monitoring a skin surface temperature at the treatment location and, when the skin surface temperature reaches a preset threshold, automatically initiating the photo-thermal treatment protocol. Further, a method for automatically terminating a treatment protocol using includes, during administration of the treatment protocol at a treatment area, monitoring a skin surface temperature at the treatment location, and when the skin surface temperature reaches a preset threshold, automatically terminating ...

COMPOSITIONS AND METHODS FOR TARGETED THERMOMODULATION

A topical cosmetic composition for use in cosmetic, diagnostic and therapeutic procedures wherein the composition comprises a cosmetically acceptable carrier and a plurality of plasmonic nanoparticles in an amount effective to induce thermomodulation in a target tissue region with which the composition is topically contacted.

SYSTEM FOR TREATING UNWANTED TISSUE

The invention may be applied to selectively heat a diseased area in the lung while minimizing heating to the healthy area and surrounding tissue. This can be done by exposing the lung to an electromagnetic field causing dielectric or eddy current heating. The invention is particularly useful for treating emphysema as the diseased areas in emphysema patients have reduced blood flow. The diseased area will heat up rapidly while the healthy tissue will be cooled by the blood flow. This is particularly effective for treating emphysema because of the low mass of the lungs and the high blood flow. To avoid heating of surrounding organs the direction of the electromagnetic energy may be switched in a way it always passes through lungs but only intermittently passes through adjacent organs.

Microwave-shielded tissue sensor probe

The invention discloses a microwave-shielded tissue sensor probe. A tissue sensor probe and corresponding electromagnetic surgical ablation system are disclosed. The system includes an ablation probe operatively coupled to a generator, a controller operatively coupled to the generator, and a tissue sensor probe operatively coupled to the controller. The tissue sensor probe includes an electrically-conductive enclosure configured to shield a temperature sensor from electromagnetic radiation produced by the ablation probe. At least a portion of the electrically-conductive enclosure is made of a high thermal-conductivity material. A material of high thermal-conductivity is disposed in the electrically-conductive enclosure in thermal association with the thermally-conductive material of the electrically-conductive enclosure. The temperature sensor is disposed in the material of high thermal conductivity so as to electrically isolate the temperature sensor from the enclosure. The temperature ...

DEVICES AND METHODS FOR SHAPING THERAPY IN FLUID ENHANCED ABLATION

Devices and methods for shaping an ablation treatment volume formed in fluid enhanced ablation therapy are provided. The devices and methods disclosed herein utilize the interaction of fluids to create ablation treatment volumes having a variety of shapes. In one embodiment, a method for forming an ablation treatment volume having a desired shape includes delivering therapeutic energy to tissue to form an ablation treatment volume and simultaneously delivering a first fluid and a second fluid to the tissue. The first and second fluids can convect the therapeutic energy in a desired direction such that the ablation treatment volume has a desired shape.

SYSTEMS, DEVICES AND METHODS FOR PERFORMING MEDICAL PROCEDURES IN THE INTESTINE

A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat at least one of non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).

SYSTEMS AND METHODS FOR MRI-GUIDED INTERSTITIAL THERMAL THERAPY

A method for magnetic resonance imaging (MRI)-guided interstitial thermal therapy includes receiving MRI data for tissue of a patient, generating an apparent diffusion coefficient (ADC) map from the MM data, identifying a target site for thermal therapy based on the ADC map, wherein the target site is identified based on an area on the ADC map with a lowest ADC value, planning the thermal therapy for the target site including identifying localized areas of the target site to be ablated first during delivery of the thermal therapy, activating a laser to deliver the thermal therapy using a laser fiber, and monitoring progress of the thermal therapy using MR thermometry.

FLUID-ASSISTED MEDICAL DEVICES, SYSTEMS AND METHODS

Surgical devices for treating tissue are provided. Also provided are systems for treating tissue and methods of treating tissue. An exemplary surgical device has a handle (20), a shaft (17) extending from the handle having a distal end, and an electrode tip (25) having an electrode surface with at least a portion of the electrode tip extending distally beyond the distal end of the shaft. In one embodiment, preferably the protion of the electrode tip extending distally beyond the distal end of the shaft comprises a cone shaped portion. The device also has a fluid passage being connectable to a fluid source and at least one fluid outlet opening in fluid communication with the fluid passage.

Skin treatment apparatus

Skin treatment apparatus comprising: a microwave source (10 figure 6); and applicator 20 for mounting over a region of skin, the applicator 20 comprising: an energy delivery structure 15a; a microwave feed structure 15. Wherein the apparatus is controllable to deliver the microwave energy such that there is an induced thermal profile in the region of the skin, the profile having a maximum temperature at a predetermined distance beneath the surface of the skin. The applicator structure may receive a cooling medium and microwave frequency electromagnetic energy, which provide a combined treatment effect that results in heating or ablation in a zone beneath the skin surface. The applicator may be a waveguide (e.g. waveguide horn antenna) with internal shielding configured to provide a substantially uniform heating effect. The applicator may include a thermal camera to monitor treatment.

BIOMEDICAL RECONDUCTING ELECTRODE WITH THERMOCHROMER LAYER

Polymers, thermochromic agents, and/or hydrogel compositions and apparatus, Including products embodying the same, and methods and processes for making same

Polymers, hydrogels, and thermochromic agents, including products embodying them, methods of using them, and processes for making them. In certain embodiments, temperature therapy packs which utilize thermochromic agents integrated into solid, semi-solid, or liquid hydrogels. In preferred (but optional) embodiments, the thermochromic agents are integrated into the composition used as the temperature exchange material of the therapy pack. In certain other embodiments, methods of using the thermochromic integrated temperature exchange materials, or processes for manufacturing such thermochromic integrated temperature exchange materials and/or methods or processes for manufacturing or using thermal packs embodying such materials. In certain particularly preferred embodiments, novel polymer compositions and/or processes for making polymers, which improve product durability or longevity and/or which improve use cycles or usage times.

Methods and devices for heating fluid in fluid enhanced ablation therapy

Devices and methods for efficiently and reproducibly heating fluid for use in fluid enhanced ablation are disclosed herein. In one embodiment, an ablation device is provided having an elongate body, at least one wire extending through an inner lumen of the elongate body, and at least one spacer disposed within the inner lumen. The at least one wire extends through the at least one spacer such that the at least one spacer is effective to maintain an adjacent portion of the at least one wire in a substantially fixed geometric relationship with the inner lumen, thereby preventing electrical shorts and providing for the consistent and uniform heating of fluid flowing through the inner lumen of the elongate body.

TEMPERATURE SENSING APPARATUS FOR USE WITH A PHOTO-THERMAL TARGETED TREATMENT SYSTEM AND ASSOCIATED METHODS

A temperature measurement system for measuring a temperature of a measured surface includes: 1) a first temperature sensor; and 2) a reference surface including a second temperature sensor integrated therein. The first temperature sensor includes a field of view simultaneously covering both at least a portion of the measured surface and at least a portion of the reference surface, thus is configured for simultaneously taking a first measurement of both the portion of the measured surface and the portion of the reference surface. The first measurement of the reference surface taken by the first temperature sensor is compared to a second measurement taken by the second temperature sensor for use in calibrating the first temperature sensor.

MICROWAVE-SHIELDED TISSUE SENSOR PROBE

A tissue sensor probe and corresponding electromagnetic surgical ablation system are disclosed. The system includes an ablation probe operatively coupled to a generator, a controller operatively coupled to the generator, and a tissue sensor probe operatively coupled to the controller. The tissue sensor probe includes an electrically-conductive enclosure configured to shield a temperature sensor from electromagnetic radiation produced by the ablation probe. At least a portion of the electrically-conductive enclosure is made of a high thermal-conductivity material. A material of high thermal-conductivity is disposed in the electrically-conductive enclosure in thermal association with the thermally-conductive material of the electrically-conductive enclosure. The temperature sensor is disposed in the material of high thermal conductivity so as to electrically isolate the temperature sensor from the enclosure. The temperature sensor provides tissue temperature to the controller, which monitors ...

COMPOSITIONS AND METHODS FOR TARGETED THERMOMODULATION

A topical cosmetic composition for use in cosmetic, diagnostic and therapeutic procedures wherein the composition comprises a cosmetically acceptable carrier and a plurality of plasmonic nanoparticles in an amount effective to induce thermomodulation in a target tissue region with which the composition is topically contacted.

PROCESSING DEVICE DERMATOLIQUE

Un dispositif (1) de traitement dermatologique comprenant une tête laser (2) apte à tirer un faisceau laser (3) en direction d'une zone cible (4) de la peau (5) d'un patient, un pyromètre (6) apte à mesurer la température (T) de la peau (5) au niveau de ladite zone cible (4), un minuteur (7) apte à mesurer la durée (D) du tir du laser, et un moyen de pilotage (8) apte à sélectivement activer ou désactiver un tir laser, où le moyen de pilotage (8) est configuré pour désactiver le tir laser lorsque la durée (D) du tir atteint un seuil de durée en secondes (Sd) tel que déterminé par une fonction affine de la forme Sd=(To-T)/C, avec T étant la température (T) mesurée de la peau, To une température objective, et C un coefficient d'échauffement moyen de la peau.

APPARATUS AND METHODS FOR CARDIAC ABLATION

An adjustable surgical clamp including one or more ablation elements creates a circular lesion in a first operating mode and a linear lesion in a second operating mode. A “box” lesion surrounding all four pulmonary veins may be formed by using the clamp to create two complimentary C-shaped lesions about pairs of the veins. A thermochromic liquid crystal strip that changes color at a tissue-ablating threshold temperature may be mounted on the surgical clamp to monitor temperature of the ablated tissue. Two microwave antennae may be positioned on the jaws of the clamp relative to each other to produce a combined substantially uniform field of tissue-ablating energy between the jaws.

METHODS AND DEVICES FOR HEATING FLUID IN FLUID ENHANCED ABLATION THERAPY

Devices and methods for efficiently and reproducibly heating fluid for use in fluid enhanced ablation are disclosed herein. In one embodiment, an ablation device is provided having an elongate body, at least one wire extending through an inner lumen of the elongate body, and at least one spacer disposed within the inner lumen. The at least one wire extends through the at least one spacer such that the at least one spacer is effective to maintain an adjacent portion of the at least one wire in a substantially fixed geometric relationship with the inner lumen, thereby preventing electrical shorts and providing for the consistent and uniform heating of fluid flowing through the inner lumen of the elongate body.

TEMPERATURE INDICATING ELECTROSURGICAL APPARATUS AND METHODS

Systems, apparatus, and methods for monitoring temperature at a region near a surgical site during a procedure. A temperature-indicating element of an electrosurgical device comprises an indicator composition adapted to undergo a change in appearance in response to a pre-defined temperature range. The change in appearance of the temperature-indicating element indicates to the operator of the device a temperature condition at the working end of the device.

Fluid-assisted medical devices, systems and methods

Surgical devices for treating tissue are provided. Also provided are systems for treating tissue and methods of treating tissue. An exemplary surgical device has a handle, a shaft extending from the handle having a distal end, and an electrode tip having an electrode surface with at least a portion of the electrode tip extending distally beyond the distal end of the shaft. In one embodiment, preferably the portion of the electrode tip extending distally beyond the distal end of the shaft comprises a cone shaped portion. The device also has a fluid passage being connectable to a fluid source and at least one fluid outlet opening in fluid communication with the fluid passage.

Anatomical phantom for simulated laser ablation procedures

Methods and devices for controlling ablation therapy

Devices and methods for controlling ablation therapy are provided herein. In one embodiment, an ablation device is provided that includes an elongate body having proximal and distal ends, and an inner lumen extending therethrough. The inner lumen can be configured to receive fluid therein and to deliver fluid to the distal end of the elongate body. The device can also include an ablation element positioned at a distal end of the elongate body that is configured to heat surrounding tissue, and a heater element disposed within the inner lumen adjacent to a distal end of thereof, the heater element being configured to heat fluid flowing through the inner lumen.

ROBOT-ASSISTED LASER SURGICAL SYSTEM

A system for working biological tissue, the system comprising: a tool comprising a laser operable to perform at least one action of work; positioning means for positioning the tool relative to the biological tissue to perform the at least one action of work; a controller; storage storing electronic program instructions for controlling the controller; and an input means; wherein the controller is operable, under control of the electronic program instructions, to: receive input via the input means; process the input and, on the basis of the processing, control the positioning means and the tool to work the biological tissue.

SYSTEM FOR OUT OF BORE FOCAL LASER THERAPY

The present invention provides methods of determining cancer margins indicating the location and breadth of treatment necessary for the elimination of cancerous tissue during focal laser therapy. The present invention also provides systems and devices for focal laser therapy, and methods for using the same. The present invention does not rely on MRI thermometry, improving accuracy of treatment while also reducing treatment time and cost.

SPECIFIC ABSORPTION RATE MEASUREMENT AND ENERGY-DELIVERY DEVICE CHARACTERIZATION USING THERMAL PHANTOM AND IMAGE ANALYSIS

A method of directing energy to tissue includes the initial step of positioning an energy applicator for delivery of energy to tissue. The energy applicator is operably associated with an electrosurgical power generating source. The method includes the steps of determining one or more operating parameters associated with the electrosurgical power generating source based on specific absorption rate data associated with the energy applicator, and transmitting energy from the electrosurgical power generating source through the energy applicator to tissue.

SYSTEM FOR OUT OF BORE FOCAL LASER THERAPY

REUSABLE PHANTOM

An embodiment of the present invention relates to a phantom for determining temperature changes, the phantom characterized by being produced with material having heat-sensitive material mixed therein, the heat-sensitive material changing color according to temperature changes, and thus the present invention has the benefit of providing a phantom which is reusable, in addition to allowing rapid and accurate examination of temperature changes due to energy emitted from a medical device.

ARTHROSCOPIC SURGICAL TEMPERATURE CONTROL SYSTEM

An arthroscopic surgical temperature control system and method able to monitor and control the temperature within a surgical site during arthroscopic ablation procedures in order to prevent tissue damage is provided.

Fluid assisted medical devices, fluid delivery systems and controllers for such devices, and methods

Medical devices, methods and systems for treating tissue are provided. An exemplary system comprises a fluid from a fluid from a fluid source at a fluid flow rate, a surgical device which provides power and the fluid to the tissue and a control mechanism which changes a fluid flow rate provided from the surgical device and changes a power level provided from the surgical device. The fluid flow rate changes between at least two-zero flow rates and the power level changes between at least two non-zero levels. An exemplary method comprises providing a fluid from a fluid source at a fluid flow rate, providing a surgical device which provides power and the fluid to the tissue, and changing the fluid flow rate of fluid provided from the surgical device with a change in power level provided from the surgical device.

METHOD AND DEVICES FOR COAGULATION OF TISSUE

Methods and devices described herein facilitate improved treatment of body organs.

Cooling systems for energy delivery devices

A reservoir for supplying a cooling fluid to a medical ablation probe includes a wall defining a chamber therein, an outlet fluid port and an inlet fluid port each in fluid communication with the chamber, cooling fluid disposed within the chamber, and a thermochromic material thermally coupled to the cooling fluid. The thermochromic material is configured to exhibit a first color when the cooling fluid is below a threshold temperature, and a second color when the cooling fluid is above the threshold temperature.

LIQUID DELIVERY SYSTEM AND CONTROL FOR ELECTRICALSURGICAL DEVICES

Polymers, thermochromic agents, and/or hydrogel compositions and apparatus, including products embodying the same, and methods and processes for making same

Polymers, hydrogels, and thermochromic agents, including products embodying them, methods of using them, and processes for making them. In certain embodiments, temperature therapy packs which utilize thermochromic agents integrated into solid, semi-solid, or liquid hydrogels. In preferred (but optional) embodiments, the thermochromic agents are integrated into the composition used as the temperature exchange material of the therapy pack. In certain other embodiments, methods of using the thermochromic integrated temperature exchange materials, or processes for manufacturing such thermochromic integrated temperature exchange materials and/or methods or processes for manufacturing or using thermal packs embodying such materials. In certain particularly preferred embodiments, novel polymer compositions and/or processes for making polymers, which improve product durability or longevity and/or which improve use cycles or usage times.

Fluid-assisted medical devices, systems and methods

Devices and methods for remote temperature monitoring in fluid enhanced ablation therapy

Devices and methods for monitoring the temperature of tissue at various locations in a treatment volume during fluid enhanced ablation therapy are provided. In one embodiment, an ablation device is provided having an elongate body, at least one ablation element, and at least one temperature sensor. The elongate body includes a proximal and distal end, an inner lumen, and at least one outlet port to allow fluid to be delivered to tissue surrounding the elongate body. The at least one ablation element is configured to heat tissue surrounding the at least one ablation element. The at least one temperature sensor can be positioned a distance away from the at least one ablation element and can be effective to output a measured temperature of tissue spaced a distance apart from the at least one ablation element such that the measured temperature indicates whether tissue is being heating to a therapeutic level.

Compositions and methods for targeted thermomodulation

COMPOSITIONS AND METHODS FOR TARGETED THERMOMODULATION Provided are nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans.

Systems and methods facilitating application of an appropriate thermal dosage in microwave ablation procedures

Provided in accordance with the present disclosure is a microwave ablation system including a microwave ablation probe configured to deliver energy to a target volume of tissue during an ablation procedure, at least one temperature sensor configured to determine a temperature of the target volume of tissue at a plurality of points in time during the ablation procedure, and a computing device operably coupled to the microwave ablation probe and the at least one temperature sensor. The computing device includes a processor and a memory storing instructions, which causes the computing device to load a temperature accumulation profile corresponding to the target volume of tissue, and dynamically control the microwave ablation probe in accordance with the temperature of the target volume of tissue at each of the points in time such that the temperature of the target volume of tissue follows the temperature accumulation profile during the ablation procedure.

METHOD AND APPARATUS FOR TREATING SOFT TISSUE INJURY

An apparatus for the treatment of a soft tissue injury (eg a soft tissue injury that may be the cause, or contributes to, acute or chronic pain such. as sciatica) comprising; a thermal imaging arrangement to scan, a least a portion of a patient to provide a thermal image; a processing arrangement to review the thermal image to determine a point or region of thermal anomaly on the patient; a laser treatment device to provide a laser beam (eg for low-level laser treatment); and a guidance arrangement for the laser treatment device to guide the laser beam to the point or region of thermal anomaly on the patient as determined by the processing arrangement; to thereby treat the patient.

COMBINED GALVANIC AND PULSED OPTICAL ENERGY FOR DEPILATION

A method for photothermolysis that includes applying galvanic current energy to skin at an area of a hair follicle and applying pulsed optical energy to the skin at the area of the hair follicle at an energy level and duration so as to cause thermal destruction of a hair papilla.

COMBINED GALVANIC AND PULSED OPTICAL ENERGY FOR DEPILATION

A method for photothermolysis that includes applying galvanic current energy to skin at an area of a hair follicle and applying pulsed optical energy to the skin at the area of the hair follicle at an energy level and duration so as to cause thermal destruction of a hair papilla.

TRANSDUCER

An embodiment of the present invention relates to a transducer comprising heat-sensitive material, in or near the area of contact with the body, the optical characteristics of which vary according to temperature changes, thereby allowing rapid and accurate examination of the temperature of the transducer without interfering with the ultrasound transmission during treatment, and thus a treatment can be safely administered by preventing damage from happening to a biosurface or the skin.

FLUID DELIVERY SYSTEM AND CONTROLLER FOR ELECTROSURGICAL DEVICES

The invention provides a system for treating tissue that includes a power measurement device, a flow rate controller coupled to the power measurement device, and an electrosurgical device configured and arranged to provide radio frequency power and conductive fluid to the tissue, wherein the flow rate controller is configured and arranged to modify a flow rate of the conductive fluid to the tissue, based on signals from the power measurement device. The invention also provides methods and devices for modifying flow rate of conductive fluid to tissue based on measurement of radio frequency power delivered to the tissue.

FLUID-ASSISTED MEDICAL DEVICES, SYSTEMS AND METHODS

Surgical devices for treating tissue are provided. Also provided are systems for treating tissue and methods of treating tissue. An exemplary surgical device has a handle, a fluid passage connectable to a fluid source, a tip portion and a distal end. The tip portion can simultaneously provide RF power and conductive fluid to tissue. The tip portion includes an electrode having a domed portion having a domed surface and a cylindrical portion having a cylindrical surface. The domed portion is located distal to the cylindrical portion and occupies at least a portion of the distal end of the surgical device. The device includes a fluid outlet opening in fluid communication with the fluid passage, the fluid outlet opening configured to provide the conductive fluid to a surface of the electrode proximal to the distal end surface of the surgical device.

Suction stabilized epicardial ablation devices

A suction assisted ablation device having a support surface, suction elements disposed adjacent the support surface, at least one electrode and at least one suction conduit is provided. The device may further include fluid openings, which allow fluid to irrigate target tissue and aid in ablation. A method for ablating tissue using suction is also provided.

Electrosurgical jaw structure for controlled energy delivery

A working end of a surgical instrument that carries first and second jaws for delivering energy to tissue. In a preferred embodiment, at least one jaw of the working end defines a tissue-engagement plane that contacts the targeted tissue. The cross-section of the engagement plane reveals that it defines a surface conductive portion that overlies a variably resistive matrix of a temperature-sensitive resistive material or a pressure-sensitive resistive material. An interior of the jaw carries a conductive material or electrode that is coupled to an Rf source and controller. In an exemplary embodiment, the variably resistive matrix can comprise a positive temperature coefficient (PTC) material, such as a ceramic, that is engineered to exhibit a dramatically increasing resistance (i.e., several orders of magnitude) above a specific temperature of the material. In use, the engagement plane will apply active Rf energy to captured tissue until the point in time that the variably resistive matrix ...

Fluid-assisted medical devices, systems and methods

Surgical devices, systems and methods for treating tissue are provided. Also provided are systems for treating tissue and methods of treating tissue. An exemplary surgical device comprises a handle (20a) having a proximal end and a distal end; a shaft extending distally beyond the distal end of the handle, the shaft having a proximal end and a distal end; an electrode tip (45), at least a portion of the electrode tip extending distally beyond the distal end of the shaft, the electrode tip extending distally beyond the distal end of the shaft comprising a spherical end surface portion (25) and a cylindrical side surface portion, the spherical end surface portion located distal to the cylindrical side surface portion and comprising at least a portion of the distal end surface of the surgical device; and a fluid passage directed to provide a fluid towards the cylindrical side portion of the electrode tip.

ARTHROSCOPIC SURGICAL TEMPERATURE CONTROL SYSTEM

Compositions and methods for targeted thermomodulation

Provided are nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans.

Methods and devices for controlling ablation therapy

Devices and methods for controlling ablation therapy are provided herein. In one embodiment, an ablation device is provided that includes an elongate body having proximal and distal ends, and an inner lumen extending therethrough. The inner lumen can be configured to receive fluid therein and to deliver fluid to the distal end of the elongate body. The device can also include an ablation element positioned at a distal end of the elongate body that is configured to heat surrounding tissue, and a heater element disposed within the inner lumen adjacent to a distal end of thereof, the heater element being configured to heat fluid flowing through the inner lumen.

Compositions and methods for targeted thermomodulation

COMPOSITIONS AND METHODS FOR TARGETED THERMOMODULATION Provided are nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans.

SYSTEMS AND METHODS FOR RADIOMETRICALLY MEASURING TEMPERATURE AND DETECTING TISSUE CONTACT PRIOR TO AND DURING TISSUE ABLATION

Illustrative embodiments provide systems and methods for radiometrically measuring temperature and detecting tissue contact during ablation. An interface module includes a first input/output (I/O) port for receiving radiometer and thermocouple signals from an integrated catheter tip (ICT) that includes a radiometer; a second I/O port for receiving ablative energy from an electrosurgical generator; a temperature display; a patient relay; a computer-readable medium storing radiometer and thermocouple parameters and instructions for causing the processor to: calculate a temperature adjacent to the ICT based on the radiometer and thermocouple signals and the parameters; causing the temperature display to display the calculated temperature; closing the patient relay to pass ablative energy from the second to the first I/O port; determining whether the ICT is in contact with tissue based on the radiometer signal. An output device indicates whether the ICT is determined to be in contact with the ...

SPECIFIC ABSORPTION RATE MEASUREMENT AND ENERGY-DELIVERY DEVICE CHARACTERIZATION USING IMAGE ANALYSIS

A method of controlling output of an electrosurgical power generating source includes the steps of receiving image data including tissue temperature information of a target tissue volume, calculating a specific absorption rate as a function of the tissue temperature information from the image data, and determining one or more operating parameters associated with the electrosurgical power generating source based on the calculated specific absorption rate.

FLUID ASSISTED MEDICAL DEVICES, FLUID DELIVERY SYSTEMS AND CONTROLLERS FOR SUCH DEVICES, AND METHODS

Medical devices, methods and systems for treating tissue are provided. An exemplary system comprises a fluid from a fluid from a fluid source at a fluid flow rate, a surgical device which provides power and the fluid to the tissue and a control mechanism which changes a fluid flow rate provided from the surgical device and changes a power level provided from the surgical device. The fluid flow rate changes between at least two-zero flow rates and the power level changes between at least two non-zero levels. An exemplary method comprises providing a fluid from a fluid source at a fluid flow rate, providing a surgical device which provides power and the fluid to the tissue, and changing the fluid flow rate of fluid provided from the surgical device with a change in power level provided from the surgical device.

Thermal treatment of acne with metal nanoparticles in surfactant containing solutions

Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. in particular, embodiments of thermal treatment of acne with metal nanoparticles in surfactant containing solutions are disclosed.

IDENTIFICATION SYSTEM FOR MEDICAL DEVICES

A system and method of use thereof are disclosed, the system including a treatment source, such as an electrosurgical generator and a plurality of treatment devices operable to be coupled to the treatment source, one or more of the treatment devices being associated with one or more device identifiers which can be, for example, physically present on the device or contained in device software.

Patent RU2019122333A3

Methods and devices for use of degassed fluids with fluid enhanced ablation devices

Devices, systems, and methods for degassing fluid prior to applying fluid to a treatment site during ablation therapy are provided. In one embodiment, an ablation system can include an elongate body, an ablation element, a heating assembly, and a fluid source. Fluid in the fluid 5 source can be at least partially degassed prior to being provided as part of the system, or, in some embodiments, a degassing apparatus can be provided that can be configured to degas fluid within the system prior to applying the fluid to the treatment site. The degassing apparatus can include one or more gas- permeable and fluid-impermeable tubes disposed therein, which can allow gas to be removed from fluid passing through the apparatus. Other exemplary devices, systems, and 10 methods are also provided.

Polymers, thermochromic agents, and/or hydrogel compositions and apparatus, including products embodying the same, and methods and processes for making same

Polymers, hydrogels, and thermochromic agents, including products embodying them, methods of using them, and processes for making them. In certain embodiments, temperature therapy packs which utilize thermochromic agents integrated into solid, semi-solid, or liquid hydrogels. In preferred (but optional) embodiments, the thermochromic agents are integrated into the composition used as the temperature exchange material of the therapy pack. In certain other embodiments, methods of using the thermochromic integrated temperature exchange materials, or processes for manufacturing such thermochromic integrated temperature exchange materials and/or methods or processes for manufacturing or using thermal packs embodying such materials. In certain particularly preferred embodiments, novel polymer compositions and/or processes for making polymers, which improve product durability or longevity and/or which improve use cycles or usage times.

SYSTEMS AND METHODS FACILITATING APPLICATION OF AN APPROPRIATE THERMAL DOSAGE IN MICROWAVE ABLATION PROCEDURES

Provided in accordance with the present disclosure is a microwave ablation system including a microwave ablation probe configured to deliver energy to a target volume of tissue during an ablation procedure, at least one temperature sensor configured to determine a temperature of the target volume of tissue at a plurality of points in time during the ablation procedure, and a computing device operably coupled to the microwave ablation probe and the at least one temperature sensor. The computing device includes a processor and a memory storing instructions, which causes the computing device to load a temperature accumulation profile corresponding to the target volume of tissue, and dynamically control the microwave ablation probe in accordance with the temperature of the target volume of tissue at each of the points in time such that the temperature of the target volume of tissue follows the temperature accumulation profile during the ablation procedure.

Thermosensitive optical probe

BIOMEDICAL RETURN ELECTRODE HAVING THERMOCHROMIC LAYER

A biomedical return electrode for electrosurgery or radiofrequency (RF), a biomedical electrode pad (100), a system (300), and a method of treating tissue using a biomedical return electrode are disclosed. The biomedical return electrode comprises an electrode conductor (114) for receiving electrical energy from tissue via a return path, and a thermochromic liquid crystal (TLC) layer (116) coupled to the conductor (114). The TLC layer (116) changes colour at one or more sites dependent upon the conductor temperature at each site. The TLC layer (116) changes colour in a predetermined range of temperatures from about 40°C to about 50°C to alert an operator about the risk of a burn occurring. The biomedical electrode pad (100) comprises at least one such biomedical return electrode and a conductive body (112) to form a contact with tissue. The system (300) comprises an apparatus for delivering electrical energy to tissue and such a biomedical electrode pad (100). The system (300) may optionally ...

THERAPEUTIC GUIDANCE COMPUTE NODE CONTROLLER

The various examples of the present disclosure are directed towards a multi-physics controller that can predict and monitor ablation procedures. In some examples of the present disclosure, fat saturation images can be used to create custom microwave ablation bioelectric/biothermal models. In some examples of the present disclosure, a deformation correction methodology can be used. Thereby, microwave and mechanics computational models can forecast therapeutic delivery intraoperatively while correcting for deformation.

DEVICE AND METHOD FOR ABLATION OF CARDIAC TISSUE

Systems and methods facilitating application of an appropriate thermal dosage in microwave ablation procedures

Provided in accordance with the present disclosure is a microwave ablation system including a microwave ablation probe configured to deliver energy to a target volume of tissue during an ablation procedure, at least one temperature sensor configured to determine a temperature of the target volume of tissue at a plurality of points in time during the ablation procedure, and a computing device operably coupled to the microwave ablation probe and the at least one temperature sensor. The computing device includes a processor and a memory storing instructions, which causes the computing device to load a temperature accumulation profile corresponding to the target volume of tissue, and dynamically control the microwave ablation probe in accordance with the temperature of the target volume of tissue at each of the points in time such that the temperature of the target volume of tissue follows the temperature accumulation profile during the ablation procedure.

METHODS AND SYSTEMS FOR COHERENT IMAGING AND FEEDBACK CONTROL FOR MODIFICATION OF MATERIALS

Methods and systems are provided for using optical interferometry in the context of material modification processes such as surgical laser, sintering, and welding applications. An imaging optical source that produces imaging light. A feedback controller controls at least one processing parameter of the material modification process based on an interferometry output generated using the imaging light. A method of processing interferograms is provided based on homodyne filtering. A method of generating a record of a material modification process using an interferometry output is provided.

ANATOMICAL PHANTOM FOR SIMULATED LASER ABLATION PROCEDURES

Disclosed herein are physiological phantoms incorporating properties of tissue that respond to laser ablation to replicate a real laser ablation procedure. The materials include waxes, polymers, thermochromic polymer blends or hydrogels, temperature sensitive hydrogels, and photodegradable hydrogels. The materials may mimic tissue as part of the tissue phantom not only in their feel and movement but also in any one or combination of their chemical, physical, mechanical, optical response to a laser ablation application. They may mimic the directionality, density, optical absorption, heat transmittance, heat conductance properties, electrochemical properties, thermochemical properties, and elasticity of the anatomical tissues they may be replicating. The laser ablation responsive materials may change properties such that they provide a measure of the success of a medical procedure.

Reusable Phantom

FLUID-ASSISTED MEDICAL DEVICES, SYSTEMS AND METHODS

A surgical device comprises a tip portion (14) including first and second jaws (16a, 16b) each having a tissue grasping surface, at least one of the jaws being movable toward the other. The tissue grasping surface of each jaw includes an electrically insulative surface. The device also includes first and second electrodes connectable to an RF generator. One of the electrode surfaces is located on one of the jaws separated from one edge of the tissue grasping surface, and the other of the electrode surfaces is located on one or the other of the jaws separated from the other edge of the tissue grasping surface. The device also includes at least one fluid passage.

TUMOR ABLATION SYSTEM

A system for use in tumor ablation. The tumor ablation system includes a microwave antenna which has a channel along the length thereof. There are two ports proximate the proximal end of the microwave antenna. The first port is an energy port configured to connect the antenna to an energy source. The second port is a fluid port configured to connect the channel to a fluid delivery mechanism. The system also includes an inflatable balloon configured to be attached to a distal end of the antenna. The channel permits fluid access from the fluid port to an interior of the balloon for inflation thereof.

Devices and methods for shaping therapy in fluid enhanced ablation

Devices and methods for shaping an ablation treatment volume formed in fluid enhanced ablation therapy are provided. The devices and methods disclosed herein utilize the interaction of fluids to create ablation treatment volumes having a variety of shapes. In one embodiment, a method for forming an ablation treatment volume having a desired shape includes delivering therapeutic energy to tissue to form an ablation treatment volume and simultaneously delivering a first fluid and a second fluid to the tissue. The first and second fluids can convect the therapeutic energy in a desired direction such that the ablation treatment volume has a desired shape.

Fluid-assisted medical devices, systems and methods

Surgical devices, systems and methods for treating tissue. An exemplary surgical device comprises a tip portion including first and second jaws each having a tissue grasping surface, at least one of the jaws being movable toward the other jaw. The tissue grasping surface of each jaw has includes an electrically insulative surface. The device also includes first and second electrodes connectable to different terminals of an RF generator to generate electrical current flow therebetween, with each of the electrodes having an electrode surface. One of the electrode surfaces is located on one of the jaws separated from one edge of the tissue grasping surface, and the other of the electrode surfaces is located on one or the other of the jaws separated from the other edge of the tissue grasping surface. The device also includes at least one fluid passage being connectable to a fluid source.

ARTHROSCOPIC SURGICAL TEMPERATURE CONTROL SYSTEM

SYSTEM AND METHOD FOR CORRELATING PROTON RESONANCE FREQUENCY THERMOMETRY WITH TISSUE TEMPERATURES

Methods and devices for use of degassed fluids with fluid enhanced ablation devices

Devices, systems, and methods for degassing fluid prior to applying fluid to a treatment site during ablation therapy are provided. In one embodiment, an ablation system can include an elongate body, an ablation element, a heating assembly, and a fluid source. Fluid in the fluid source can be at least partially degassed prior to being provided as part of the system, or, in some embodiments, a degassing apparatus can be provided that can be configured to degas fluid within the system prior to applying the fluid to the treatment site. The degassing apparatus can include one or more gas- permeable and fluid-impermeable tubes disposed therein, which can allow gas to be removed from fluid passing through the apparatus. Other exemplary devices, systems, and methods are also provided.

POLYMERS, THERMOCHROMIC AGENTS,AND/OR HYDROGEL COMPOSITIONS AND APPARATUS, INCLUDING PRODUCTS EMBODYING THE SAME, AND METHODS AND PROCESSES FOR MAKING SAME

MEDICAL SYSTEMS WITH A TEMPERATURE SENSOR OR A TEMPERATURE MEASURING APPARATUS

In order to provide a temperature sensor or a temperature measuring apparatus having a temperature sensor, which enables direct temperature measurement, in particular even during treatment, in particular even with HF surgical devices, it is proposed that the temperature sensor comprises a sensor element with a medium which can be excited to luminescence, in particular fluorescence, and an optical waveguide which is optically connected to the sensor element and is intended to supply light to the medium at an excitation wavelength and/or to pick up and conduct light at a luminescence wavelength of the medium which can be excited to luminescence.

Suction stabilized epicardial ablation devices

A suction assisted ablation device having a support surface, suction elements disposed adjacent the support surface, at least one electrode and at least one suction conduit is provided. The device may further include fluid openings, which allow fluid to irrigate target tissue and aid in ablation. A method for ablating tissue using suction is also provided.

Suction stabilized epicardial ablation devices

A suction assisted ablation device having a support surface, suction elements disposed adjacent the support surface, at least one electrode and at least one suction conduit is provided. The device may further include fluid openings, which allow fluid to irrigate target tissue and aid in ablation. A method for ablating tissue using suction is also provided.

Specific Absorption Rate Measurement and Energy-Delivery Device Characterization Using Image Analysis

A method of controlling output of an electrosurgical power generating source includes the steps of receiving image data including tissue temperature information of a target tissue volume, calculating a specific absorption rate as a function of the tissue temperature information from the image data, and determining one or more operating parameters associated with the electrosurgical power generating source based on the calculated specific absorption rate.

Specific Absorption Rate Measurement and Energy-Delivery Device Characterization Using Thermal Phantom and Image Analysis

A method of directing energy to tissue includes the initial step of positioning an energy applicator for delivery of energy to tissue. The energy applicator is operably associated with an electrosurgical power generating source. The method includes the steps of determining one or more operating parameters associated with the electrosurgical power generating source based on specific absorption rate data associated with the energy applicator, and transmitting energy from the electrosurgical power generating source through the energy applicator to tissue.

Device and method for ablation of cardiac tissue

Methods for delivering precise amounts of fluid into cardiac tissue for the purpose of facilitating ablation of the tissue along a desired lesion line. One method injects fluid through a hollow needle. The injected fluid can be a highly conductive fluid injected in conjunction with radiofrequency ablation to create an ablative virtual electrode. The injected conductive fluid can provide deeper and narrower conduction paths and resulting lesions. Radiofrequency ablation can be performed at the same time as the fluid injection, using the injection device as an electrode, or subsequent to the fluid injection, using a separate device. In some methods, the injected fluid is a protective fluid, injected to protect tissue adjacent to the desired lesion line. Fluid delivery can be endocardial, epicardial, and epicardial on a beating heart. The present methods find one use in performing maze procedures to treat atrial fibrillation.

Anatomical phantom for simulated laser ablation procedures

Disclosed herein are physiological phantoms incorporating properties of tissue that respond to laser ablation to replicate a real laser ablation procedure. The materials include waxes, polymers, thermochromic polymer blends or hydrogels, temperature sensitive hydrogels, and photodegradable hydrogels. The materials may mimic tissue as part of the tissue phantom not only in their feel and movement but also in any one or combination of their chemical, physical, mechanical, optical response to a laser ablation application. They may mimic the directionality, density, optical absorption, heat transmittance, heat conductance properties, electrochemical properties, thermochemical properties, and elasticity of the anatomical tissues they may be replicating. The laser ablation responsive materials may change properties such that they provide a measure of the success of a medical procedure.

Devices and methods for shaping therapy in fluid enhanced ablation

Devices and methods for shaping an ablation treatment volume formed in fluid enhanced ablation therapy are provided. The devices and methods disclosed herein utilize the interaction of fluids to create ablation treatment volumes having a variety of shapes. In one embodiment, a method for forming an ablation treatment volume having a desired shape includes delivering therapeutic energy to tissue to form an ablation treatment volume and simultaneously delivering a first fluid and a second fluid to the tissue. The first and second fluids can convect the therapeutic energy in a desired direction such that the ablation treatment volume has a desired shape.

Methods and devices for heating fluid in fluid enhanced ablation therapy

Devices and methods for efficiently and reproducibly heating fluid for use in fluid enhanced ablation are disclosed herein. In one embodiment, an ablation device is provided having an elongate body, at least one wire extending through an inner lumen of the elongate body, and at least one spacer disposed within the inner lumen. The at least one wire extends through the at least one spacer such that the at least one spacer is effective to maintain an adjacent portion of the at least one wire in a substantially fixed geometric relationship with the inner lumen, thereby preventing electrical shorts and providing for the consistent and uniform heating of fluid flowing through the inner lumen of the elongate body.

Surgical laser treatment temperature monitoring

A surgical laser system includes a laser source configured to generate laser energy, a laser fiber optically coupled to the laser source and configured to discharge the laser energy and collect electromagnetic energy feedback from a treatment site, a photodetector configured to generate an output signal in response to the electromagnetic energy collected from the treatment site, a display, and a controller configured to produce an image or indication about the temperature at the treatment site on the display based on the output signal.

Specific absorption rate measurement and energy-delivery device characterization using image analysis

SPECIFIC ABSORPTION RATE MEASUREMENT AND ENERGY DELIVERY DEVICE CHARACTERIZATION USING IMAGE Abstract A method of controlling output of an electrosurgical power generating source includes the steps of receiving image data (2230) including tissue temperature information of a target tissue volume, calculating a specific absorption rate as a function of the tissue temperature information from the image data (2260), and determining one or tO more operating parameters associated with the electrosurgical power generating source based on the calculated specific absorption rate (2270). r2210 POSITION AN ENERGY APPLICATOR FOR DELIVER OF ENERGY TO A TARGET TISSUE VOLUME _IF r2220 TRANSMIT ENERGY FROM AN ENERGY SOURCE THROUGH THE ENERGY APPLICATOR TO THE TARGET TISSUE VOLUME IF_ r2230 ACQUIRE IMAGE DATA INCLUDING TISSUE TEMPERATURE INFORMATION OF THE TARGET TISSUE VOLUME BY IMAGING THE TARGET TISSUE VOLUME USING ONE OR MORE IMAGING MODALITIES STORE THE IMAGE DATA IN DICOM 22503 FORMAT IN A PACS DATABASE ...

Methods and devices for heating fluid enhanced ablation therapy

Devices and methods for efficiently and reproducibly heating fluid for use in fluid enhanced ablation are disclosed herein. In one embodiment, an ablation device is provided having an elongate body, at least one wire extending through an inner lumen of the elongate body, and at least one spacer disposed within the inner lumen. The at least one wire extends through the at least one spacer such that the at least one spacer is effective to maintain an adjacent portion of the at least one wire in a substantially fixed geometric relationship with the inner lumen, thereby preventing electrical shorts and providing for the consistent and uniform heating of fluid flowing through the inner lumen of the elongate body.

METHOD AND SYSTEM FOR CONCURRENT PHOTOTHERMAL ABLATION AND INTERSTITIAL PHOTODYNAMIC THERAPY

The present disclosure provides a method and a system for treating a tissue using photodynamic therapy (PDT). A photosensitizer is administered to the tissue and one or more optical fibers are placed in the tissue. A treatment light is applied to the tissue by way of the one or more optical fibers. A temperature of the tissue is measured during application of the treatment light, and a fluence rate of the treatment light is modified based on the temperature of the tissue. For example, the fluence rate may be modified to be lower if the temperature of the tissue is higher than a predetermined threshold.

DISPOSITIF DE TRAITEMENT DERMATOLOGIQUE

Un dispositif (1) de traitement dermatologique comprenant une tête laser (2) apte à tirer un faisceau laser (3) en direction d'une zone cible (4) de la peau (5) d'un patient, un pyromètre (6) apte à mesurer la température (T) de la peau (5) au niveau de ladite zone cible (4), un minuteur (7) apte à mesurer la durée (D) du tir du laser, et un moyen de pilotage (8) apte à sélectivement activer ou désactiver un tir laser, où le moyen de pilotage (8) est configuré pour désactiver le tir laser lorsque la durée (D) du tir atteint un seuil de durée en secondes (Sd) tel que déterminé par une fonction affine de la forme Sd=(To-T)/C, avec T étant la température (T) mesurée de la peau, To une température objective, et C un coefficient d'échauffement moyen de la peau.

sistema de tratamento com foco foto-térmico com pré-condicionamento integrado e acionamento automático de tratamento com foco foto-térmico através de medição da temperatura da superfície da pele e métodos associados

DEVICE AND METHOD FOR ABLATION OF CARDIAC TISSUE

TRANSMURAL SUBSURFACE INTERROGATION AND ABLATION

Transmural subsurface interrogation and ablation apparatus and methods are described where tissue to be ablated is monitored while under direct visualization for tissue parameters (e.g., temperature and impedance) prior to, during, or after ablation. Such a system may include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to the tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid can be pumped into the imaging hood until the fluid displaces any blood leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. An ablation probe and one or more interrogation needles having sensors are advanced into the tissue to be ablated and monitored. Alternatively, a combined ablation and interrogation probe may be used.

Temperature indicating electrosurgical apparatus and methods

Systems, apparatus, and methods for monitoring temperature at a region near a surgical site during a procedure. A temperature-indicating element of an electrosurgical device comprises an indicator composition adapted to undergo a change in appearance in response to a pre-defined temperature range. The change in appearance of the temperature-indicating element indicates to the operator of the device a temperature condition at the working end of the device.

DEVICES AND METHODS FOR REMOTE TEMPERATURE MONITORING IN FLUID ENHANCED ABLATION THERAPY

Devices and methods for monitoring the temperature of tissue at various locations in a treatment volume during fluid enhanced ablation therapy are provided. In one embodiment, an ablation device is provided having an elongate body, at least one ablation element, and at least one temperature sensor. The elongate body includes a proximal and distal end, an inner lumen, and at least one outlet port to allow fluid to be delivered to tissue surrounding the elongate body. The at least one ablation element is configured to heat tissue surrounding the at least one ablation element. The at least one temperature sensor can be positioned a distance away from the at least one ablation element and can be effective to output a measured temperature of tissue spaced a distance apart from the at least one ablation element such that the measured temperature indicates whether tissue is being heating to a therapeutic level.

Apparatus and methods for cardiac ablation

An adjustable surgical clamp including one or more ablation elements creates a circular lesion in a first operating mode and a linear lesion in a second operating mode. A "box" lesion surrounding all four pulmonary veins may be formed by using the clamp to create two complimentary C-shaped lesions about pairs of the veins. A thermochromic liquid crystal strip that changes color at a tissue-ablating threshold temperature may be mounted on the surgical clamp to monitor temperature of the ablated tissue. Two microwave antennae may be positioned on the jaws of the clamp relative to each other to produce a combined substantially uniform field of tissue-ablating energy between the jaws.

Thermal treatment of a pilosebaceous unit with metal nanoparticles in surfactant containing solutions

Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. In particular, embodiments of thermal treatment of a pilosebaceous unit with metal nanoparticles in surfactant containing solutions are disclosed.

Dermatological treatment device

The invention relates to a dermatological treatment device ( 1 ) including a laser head ( 2 ) capable of shooting a laser beam ( 3 ) towards a target region ( 4 ) of the skin ( 5 ) of a patient, a pyrometer ( 6 ) capable of measuring the temperature (T) of the skin ( 5 ) in said target region ( 4 ), a timer ( 7 ) capable of measuring the duration (D) of the laser shot, and a control means ( 8 ) capable of selectively activating or deactivating a laser shot, the control means ( 8 ) being configured to deactivate the laser shot when the duration (D) of the shot reaches a duration threshold in seconds (Sd) as determined by a linear function in the form Sd=(To−T)/C, where T is the measured temperature (T) of the skin, To is a target temperature, and C is an average heating coefficient of the skin.

IRRIGATED ABLATION ELECTRODE ASSEMBLY HAVING OFF-CENTER IRRIGATION PASSAGEWAY

An irrigated ablation catheter includes a shaft and an electrode assembly affixed to a distal end of the shaft. The distal electrode assembly includes a manifold and an ablation electrode affixed together and extending along a center axis. The electrode has a distal irrigation passageway extending therethrough to an opening at a distal tip of the electrode. The opening of the irrigation passageway is offset in distance from the center axis, and allows a thermal sensor such as a thermocouple to be located in a sensor cavity in the electrode on or near the center axis. One variation involves providing a pair of distal irrigation passageways through the electrode where both of the openings of the passageways are offset from the center axis. The thermal sensor in this variation is located in the sensor cavity substantially on the center axis. 125.-. (canceled)26. A distal assembly of an irrigated ablation catheter , comprising:a manifold and an ablation electrode extending along a central axis;a temperature sensor disposed in the electrode configured to produce a temperature signal indicative of a temperature value of the electrode;the manifold comprising a distribution cavity, wherein the manifold is configured for connection to a distal end of a shaft of the catheter, and wherein a longitudinal axis of at least a portion of the distribution cavity is offset in distance from the central axis by a first amount of offset;the ablation electrode including a first irrigation passageway.27. The assembly of wherein the thermal sensor and the ablation electrode are configured to be thermally insulated from the first irrigation passageway.28. The assembly of wherein the temperature sensor comprises one of a thermocouple and a thermistor.29. The assembly of wherein the first irrigation passageway comprises a first opening at a distal tip of the electrode.30. The assembly of wherein the manifold includes a main body having the distribution cavity in communication with an inlet ...

METHODS AND DEVICES FOR HEATING FLUID IN FLUID ENHANCED ABLATION THERAPY

Devices and methods for efficiently and reproducibly heating fluid for use in fluid enhanced ablation are disclosed herein. In one embodiment, an ablation device is provided having an elongate body, at least one wire extending through an inner lumen of the elongate body, and at least one spacer disposed within the inner lumen. The at least one wire extends through the at least one spacer such that the at least one spacer is effective to maintain an adjacent portion of the at least one wire in a substantially fixed geometric relationship with the inner lumen, thereby preventing electrical shorts and providing for the consistent and uniform heating of fluid flowing through the inner lumen of the elongate body. 1. An ablation device , comprising: proximal and distal ends,', 'an inner lumen extending through the elongate body, and', 'at least one outlet port formed in the elongate body configured to deliver fluid to tissue surrounding the elongate body;, 'an elongate body having'}at least one wire extending through the inner lumen, the at least one wire being configured to heat fluid flowing through the inner lumen; andat least one spacer disposed within the inner lumen, the at least one wire extending through the at least one spacer such that the at least one spacer is effective to maintain an adjacent portion of the at least one wire in a substantially fixed geometric relationship with the inner lumen.2. The ablation device of claim 1 , further comprising an ablation element disposed along a length of the elongate body adjacent to the at least one outlet port claim 1 , the ablation element being configured to heat tissue surrounding the ablation element when the elongate body is inserted into tissue.3. The ablation device of claim 2 , wherein the at least one wire and the at least one spacer are positioned proximal of the ablation element.4. The ablation device of claim 1 , wherein the at least one spacer comprises a first spacer positioned at a proximal end of a ...

METHODS AND DEVICES FOR CONTROLLING ABLATION THERAPY

Devices and methods for controlling ablation therapy are provided herein. In one embodiment, an ablation device is provided that includes an elongate body having proximal and distal ends, and an inner lumen extending therethrough. The inner lumen can be configured to receive fluid therein and to deliver fluid to the distal end of the elongate body. The device can also include an ablation element positioned at a distal end of the elongate body that is configured to heat surrounding tissue, and a heater element disposed within the inner lumen adjacent to a distal end of thereof, the heater element being configured to heat fluid flowing through the inner lumen. 1. An ablation device , comprising:an elongate body having proximal and distal ends, and an inner lumen extending therethrough, the inner lumen being configured to receive fluid therein and to deliver fluid to the distal end of the elongate body;an ablation element positioned at the distal end of the elongate body, the ablation element being configured to heat surrounding tissue; anda heater element disposed within the inner lumen adjacent to the distal end of the elongate body, the heater element being configured to heat fluid flowing through the inner lumen.2. The device of claim 1 , wherein the inner lumen includes a delivery lumen configured to deliver fluid from the proximal end to the distal end of the elongate body claim 1 , and a return lumen configured to receive fluid delivered to the distal end of the elongate body and to return the fluid to the proximal end of the elongate body.3. The device of claim 1 , wherein the elongate body includes one or more outlet ports formed through a sidewall thereof adjacent to the distal end thereof claim 1 , the outlet ports being configured to allow fluid to flow from the inner lumen and into surrounding tissue.4. The device of claim 1 , further comprising a temperature sensor disposed on a distal end of the ablation element.5. The device of claim 1 , further ...

SYSTEMS, DEVICES AND METHODS FOR PERFORMING MEDICAL PROCEDURES IN THE INTESTINE

A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat at least one of non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH). 1. A method for performing a medical procedure in an intestine of a patient , comprising:selecting a patient diagnosed with at least one of non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH);providing a system comprising:a catheter for insertion into the intestine, the catheter comprising:an elongate shaft comprising a distal portion; anda functional assembly positioned on the shaft distal portion and comprising at least one treatment element;introducing the catheter into the patient diagnosed with at least one of NAFLD or NASH; andtreating target tissue with the at least one treatment element, wherein the target tissue comprises mucosal tissue of the patient's small intestine;wherein the medical procedure is configured to treat the at least one of NAFLD or NASH.2. The method according to claim 1 , wherein the medical procedure is further configured to treat insulin resistance.3. The method according to claim 1 , wherein the medical procedure is further configured to treat a disease or disorder selected from the group consisting. of: Type 2 diabetes; Type 1 diabetes; “Double diabetes”; gestational diabetes; hyperglycemia; pre-diabetes; impaired glucose tolerance; insulin resistance; and combinations thereof.4. The method according to claim 1 , ...

SYSTEMS, DEVICES AND METHODS FOR PERFORMING MEDICAL PROCEDURES IN THE INTESTINE

A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat polycystic ovarian syndrome (PCOS). 1. A method for treating a patient diagnosed as having polycystic ovarian syndrome , said method comprising:treating a target mucosal tissue of the patient's small intestine to modify at least one of nutrient absorption by the target mucosal tissue, hormonal signaling from the target mucosal tissue, or secretions of the target tissue, wherein the treatment is configured to treat polycystic ovarian syndrome.2. The method according to claim 1 , wherein the medical procedure is further configured to treat insulin resistance.3. The method according to claim 1 , wherein the medical procedure is further configured to treat a disease or disorder selected from the group consisting of: Type 2 diabetes;Type 1 diabetes; “Double diabetes”; gestational diabetes; hyperglycemia; pre-diabetes; impaired glucose tolerance; insulin resistance; and combinations thereof.4. The method according to claim 1 , wherein treatment is performed with a system comprising:a catheter for insertion into the intestine, the catheter comprising:an elongate shaft comprising a distal portion;a functional assembly positioned on the shaft distal portion and comprising at least one treatment element; anda console operably attached to the functional assembly, and wherein the console comprises one or more variable console parameters used to control the functional assembly;and wherein ...

Disposable Fluid Circuit with Thermochromic Indicator

A system of temperature measurement and control in which temperature of the medical fluid being conveyed through a medical device is indirectly measured and controlled via sensed color change of an of an inexpensive injected molded or extruded thermochromic flow chamber. 1. A dialysis tubing set comprising:at least one fluid line configured to connect a dialysis fluid source and a pump of a dialysis machine; anda flow chamber connected to the at least one fluid line, the flow chamber having a thermochromic material configured to change color when exposed to a specified temperature range.2. The dialysis tubing set of claim 1 , wherein the thermochromic material is configured to remain visible to a user.3. The dialysis tubing set of claim 1 , wherein configured to be aligned with an optical sensor of a dialysis machine.4. The dialysis tubing set of claim 3 , wherein the optical sensor is a color sensor.5. The dialysis tubing of claim 1 , wherein the thermochromic material comprises at least two thermochromic elements each configured to change color at a different temperature.6. The dialysis tubing set of claim 5 , wherein each thermochromic element is positioned on a different side of the flow chamber.7. The dialysis tubing set of claim 6 , wherein a first thermochromic component is positioned above a second thermochromic component.8. The dialysis tubing set of claim 1 , wherein the thermochromic material is configured as an insert and is positioned within the at least one fluid line.9. The dialysis tubing set of claim 8 , wherein the at least one fluid line comprises a first fluid path through a central channel of the insert and a second fluid path between the insert and the at least one fluid line.10. The dialysis tubing set of claim 1 , wherein the specified temperature range is between 35-39° C.11. The dialysis tubing set of claim 1 , wherein the thermochromic material is positioned along an external surface of the flow chamber.12. A dialysis cassette comprising:a ...

Handpiece for treatment, treatment device including handpiece, and treatment method using treatment device

A handpiece for treatment according to an embodiment of the present invention comprises: a housing having at least one through-hole formed in the tip end thereof; an insertion part that passes through the surface of tissue and is inserted into the tissue in a state in which at least a portion thereof is exposed through the through-hole; and a cooling channel for providing a cooling gas that is supplied to the surface of the tissue through the through-hole.

Fluid-assisted medical devices, systems and methods

Surgical devices, systems and methods for treating tissue are provided. Also provided are systems for treating tissue and methods of treating tissue. An exemplary surgical device comprises a handle ( 20 a ) having a proximal end and a distal end; a shaft extending distally beyond the distal end of the handle, the shaft having a proximal end and a distal end; an electrode tip ( 45 ), at least a portion of the electrode tip extending distally beyond the distal end of the shaft, the electrode tip extending distally beyond the distal end of the shaft comprising a spherical end surface portion ( 25 ) and a cylindrical side surface portion, the spherical end surface portion located distal to the cylindrical side surface portion and comprising at least a portion of the distal end surface of the surgical device; and a fluid passage directed to provide a fluid towards the cylindrical side portion of the electrode tip.

Bladder temperature measurement for high intensity focused ultrasound

The invention provides for a medical instrument ( 100 ) comprising: a high intensity focused ultrasound system ( 122 ) for sonicating a target region ( 139 ) within a subject ( 118 ); a light source ( 158 ) for exciting a temperature sensitive fluorescent dye, wherein the light source is configured for coupling to an optical fiber cable ( 148 ) of a urinary catheter ( 140 ); a light source ( 160 ) for measuring fluorescence ( 190 ) emitted by the temperature sensitive fluorescent dye, wherein the light source is configured for coupling to the optical fiber cable; a memory ( 178 ) for storing machine executable instructions ( 180 ); and a processor ( 174 ) for controlling the medical instrument. Execution of the machine executable instructions cause the processor to: receive ( 200 ) a sonication plan ( 188 ) descriptive of a sonication of the target region; measure ( 202 ) the fluorescence using the light sensor; calculate ( 204 ) a bladder temperature ( 192 ) using the fluorescence; and generate ( 206 ) sonication commands ( 194 ) using the sonication plan and the bladder temperature, wherein the sonication commands are adapted for controlling the high intensity focused ultrasound system to sonicate the target region.

Thermal treatment of a pilosebaceous unit with coated metal nanoparticles

Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. In particular, embodiments of thermal treatment of a pilosebaceous unit with coated metal nanoparticles are disclosed.

Polymers, Thermochromic Agents, And/Or Hydrogel Compositions And Apparatus, Including Products Embodying The Same, And Methods And Processes For Making Same

Polymers, hydrogels, and thermochromic agents, including products embodying them, methods of using them, and processes for making them. In certain embodiments, temperature therapy packs which utilize thermochromic agents integrated into solid, semi-solid, or liquid hydrogels. In preferred (but optional) embodiments, the thermochromic agents are integrated into the composition used as the temperature exchange material of the therapy pack. In certain other embodiments, methods of using the thermochromic integrated temperature exchange materials, or processes for manufacturing such thermochromic integrated temperature exchange materials and/or methods or processes for manufacturing or using thermal packs embodying such materials. In certain particularly preferred embodiments, novel polymer compositions and/or processes for making polymers, which improve product durability or longevity and/or which improve use cycles or usage times.

METHOD AND DEVICES FOR COAGULATION OF TISSUE

Methods and devices described herein facilitate improved treatment of body organs. 1positioning a first medical treatment device adjacent to the first tissue surface;forming a first portion of the treatment pattern along the first tissue surface using the medical treatment device such that the first portion of the treatment pattern is incomplete;positioning a second medical device having at least one energy source adjacent to the second tissue surface;applying energy adjacent to the second tissue surface using the energy source;identifying a location of the energy source through the target tissue from the first tissue surface to locate the second medical device; andrepositioning the second medical device on the second tissue surface in response to the location of the first portion of the treatment pattern and using the second medical device to form a second portion of the treatment pattern on the second tissue surface to complete the treatment pattern.. A method of creating a treatment pattern in a target tissue, where the target tissue comprises a first tissue surface and a second tissue surface, where the second tissue surface is on an opposite side of the first tissue surface, the method comprising: This application is a continuation of U.S. patent application Ser. No. 13/541,580 filed Jul. 3, 2012, which is a continuation of U.S. patent application Ser. No. 12/685,596 filed Jan. 11, 2010, which is a non-provisional of U.S. Provisional Application No. 61/143,688 filed Jan. 9, 2009 entitled “Minimally Invasive Lesion Pattern and Dissecting Instruments Utilizing Endocardial and Epicardial Lesions”. The above filings are hereby incorporated by reference in its entirety.Methods and devices are disclosed herein for therapeutically treating tissue. In one example, the devices and methods are suitable for minimally invasive surgery. More particularly, methods and devices described herein permit creating an ablation pattern on an organ while reducing excessive trauma to ...

TEMPERATURE INDICATOR FOR FIBER CONNECTORS AND METHODS REGARDING SAME

A medical laser fiber for receiving laser light and outputting the laser light to a location determined by a user, the fiber including a connector at a first end, and a laser output at a second end, and an indicator located on the connector, the indicator visually changing when a temperature of the connector is above a temperature threshold.

Ablation systems, probes, and methods for reducing radiation from an ablation probe into the environment

The ablation systems, ablation probes, and corresponding methods according to the present disclosure reduce or eliminate energy radiating from an ablation probe into the environment. Some ablation probes include a retractable sheath that shields at least the radiating portion of the ablation probe. The retractable sheath and/or the ablation probe may include conduits through which a fluid may flow to shield the radiating portion and to drive the retractable sheath to an extended state. Other ablation probes include apertures defined in the probe walls through which the fluid can flow to expand a balloon surrounding the radiating portion. Yet other ablation probes include a thermal indicator to indicate the temperature of the ablation probe to a user. The ablation systems include fluid circuits and associated mechanical controls for varying the contents and/or flow rate of the fluid provided to the radiating portion of the ablation probe.

Polymers, thermochromic agents, and/or hydrogel compositions and apparatus, including products embodying the same, and methods and processes for making same

Polymers, hydrogels, and thermochromic agents, including products embodying them, methods of using them, and processes for making them. In certain embodiments, temperature therapy packs which utilize thermochromic agents integrated into solid, semi-solid, or liquid hydrogels. In preferred (but optional) embodiments, the thermochromic agents are integrated into the composition used as the temperature exchange material of the therapy pack. In certain other embodiments, methods of using the thermochromic integrated temperature exchange materials, or processes for manufacturing such thermochromic integrated temperature exchange materials and/or methods or processes for manufacturing or using thermal packs embodying such materials. In certain particularly preferred embodiments, novel polymer compositions and/or processes for making polymers, which improve product durability or longevity and/or which improve use cycles or usage times.

DEVICES AND METHODS FOR SHAPING THERAPY IN FLUID ENHANCED ABLATION

Devices and methods for shaping an ablation treatment volume formed in fluid enhanced ablation therapy are provided. The devices and methods disclosed herein utilize the interaction of fluids to create ablation treatment volumes having a variety of shapes. In one embodiment, a method for forming an ablation treatment volume having a desired shape includes delivering therapeutic energy to tissue to form an ablation treatment volume and simultaneously delivering a first fluid and a second fluid to the tissue. The first and second fluids can convect the therapeutic energy in a desired direction such that the ablation treatment volume has a desired shape. 1. A method for forming an ablation treatment volume in tissue having a desired shape , comprising:delivering therapeutic energy to tissue to form an ablation treatment volume in the tissue; andsimultaneously delivering a first fluid and a second fluid to the tissue, the first and second fluids convecting the therapeutic energy in a desired direction such that the ablation treatment volume has a desired shape.2. The method of claim 1 , wherein the first and second fluids are delivered at different temperatures.3. The method of claim 1 , wherein the first and second fluids are delivered through one or more elongate bodies inserted into the tissue.4. The method of claim 1 , further comprising adjusting any of a fluid flow rate and a fluid temperature for any of the first fluid and the second fluid to further shape the ablation treatment volume.5. The method of claim 1 , further comprising adjusting a level of therapeutic energy delivered to the tissue to further shape the ablation treatment volume.6. The method of claim 1 , wherein delivering therapeutic energy to tissue comprises activating an ablation element configured to transmit electrical energy into the tissue.7. The method of claim 1 , wherein the first fluid is delivered from first and second opposed longitudinal portions of an inner lumen of an elongate body ...

Methods and devices for heating fluid in fluid enhanced ablation therapy

Devices and methods for efficiently and reproducibly heating fluid for use in fluid enhanced ablation are disclosed herein. In one embodiment, an ablation device is provided having an elongate body, at least one wire extending through an inner lumen of the elongate body, and at least one spacer disposed within the inner lumen. The at least one wire extends through the at least one spacer such that the at least one spacer is effective to maintain an adjacent portion of the at least one wire in a substantially fixed geometric relationship with the inner lumen, thereby preventing electrical shorts and providing for the consistent and uniform heating of fluid flowing through the inner lumen of the elongate body.

Heat exchange systems for robotic surgical systems

Various cooling systems are disclosed for a robotic surgical system that comprises a robotic arm and an end effector movable by the robotic arm. A cooling assembly can comprise a first enclosure within a sterile environment and a second enclosure external to the sterile environment. The first enclosure can be fluidically isolated from the sterile environment. The first enclosure can comprises or house a motor configured to actuate the end effector in the sterile environment. The first enclosure and the second enclosure can be thermally and fluidically coupled to transfer thermal energy from the motor housed within the first enclosure.

Visual electrode ablation systems

Visual electrode ablation systems are described herein which include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. An electric current may be passed through the fluid such that it passes directly to the tissue region being imaged and the electrical energy is conducted through the fluid without the need for a separate ablation probe or instrument to ablate the tissue being viewed.

Topical cosmetic or pharmaceutical composition

Topische kosmetische oder pharmazeutische Zusammensetzung, umfassend einen kosmetisch verträglichen Träger, und eine Vielzahl von plasmonischen Nanopartikeln in einer Menge von 109 bis 1018 Nanopartikeln pro Milliliter der Zusammensetzung, wobei die plasmonischen Nanopartikel Silber oder Gold umfassen, wobei die plasmonischen Nanopartikel Laser-Anregung mit Wellenlängen von etwa 755 nm, mit Wellenlängen im Bereich von etwa 800 bis 810 nm oder mit Wellenlängen von etwa 1064 nm optisch absorbieren, und wobei die plasmonischen Nanopartikel eine hydrophile oder aliphatische Beschichtung umfassen, wobei die Beschichtung nicht wesentlich an die Haut eines Säugers adsorbiert, und wobei die Beschichtung aus Polyethylenglykol, Siliziumdioxid, oder Polystyrol ausgewählt ist. A topical cosmetic or pharmaceutical composition comprising a cosmetically acceptable carrier, and a plurality of plasmonic nanoparticles in an amount of 109 to 1018 nanoparticles per milliliter of the composition, wherein the plasmonic nanoparticles comprise silver or gold, wherein the plasmonic nanoparticles excite laser excitation at wavelengths of about 755 nm, with wavelengths in the range of about 800 to 810 nm or at wavelengths of about 1064 nm, and wherein the plasmonic nanoparticles comprise a hydrophilic or aliphatic coating, wherein the coating does not substantially adsorb to the skin of a mammal, and wherein the coating is selected from polyethylene glycol, silica, or polystyrene.

Determination process and forecast control with feedback dosimetry using measurement of skin surface temperature and correct methods

FIELD: medical technology. SUBSTANCE: inventions relates to medical technology. Determination of a suitable set of parameters for the operation of a radiation source in a photothermal targeted therapy system for targeted action on a chromophore embedded in a medium is disclosed. Before using the therapy protocol, the following is carried out: 1) applying at least one laser pulse from a radiation source with a preset power level at the location to be treated, the preset power level being below a known damage threshold; 2) measuring the temperature of the skin surface at the location to be treated after application of the at least one laser pulse; 3) evaluation of the relationship between the parameters of the radiation source and the temperature of the skin surface; and 4) defining a safe operating range for the radiation source to prevent thermal damage to the environment at the location to be treated, provided that the chromophore is effectively targeted when the therapy protocol is applied. EFFECT: photothermal targeted therapy improvement. 15 cl, 8 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 765 091 C1 (51) МПК A61B 18/20 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61B 18/20 (2021.08) (21)(22) Заявка: 2021114363, 21.10.2019 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): ЭККЬЮР ЭКНИ, ИНК. (US) Дата регистрации: 25.01.2022 Приоритет(ы): (30) Конвенционный приоритет: 26.11.2018 US 62/771,523; 22.10.2018 US 62/749,104 (45) Опубликовано: 25.01.2022 Бюл. № 3 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 24.05.2021 (86) Заявка PCT: 2 7 6 5 0 9 1 (56) Список документов, цитированных в отчете о поиске: US 20140121631 A1, 01.05.2014. US 20130178916 A1, 11.07.2013. RU 2620357 C2, 24.05.2017. EP 2499985 A1, 19.09.2012. US 20140371736 A1, 18.12.2014. R U 21.10.2019 (72) Автор(ы): ХОФВАНДЕР, Хенрик (HU) 2 7 6 5 0 9 1 R U C 1 C 1 US 2019/057209 (21.10.2019) (87) ...

System for photothermal targeted therapy with integrated pre-conditioning and automatic initiation of photothermal targeted therapy by measuring the skin surface temperature, and corresponding methods

FIELD: medical equipment. SUBSTANCE: system for photothermal targeted therapy for damaging a target object embedded in the environment includes a controller and a photothermal therapy unit including a radiation source. The controller is configured to apply a therapy protocol using the radiation source with a preset power setting parameter and a preset pulse synchronisation setting parameter. Method for automatically initiating a therapy protocol using the system for photothermal targeted therapy includes applying a cooling mechanism at the therapy site, monitoring the temperature of the skin surface at the therapy site, and automatically initiating the photothermal therapy protocol when the temperature of the skin surface reaches a predetermined threshold. Method for automatically completing a therapy protocol includes monitoring the temperature of the skin surface at the therapy site in the process of applying the therapy protocol in the therapy area, and automatically completing the therapy protocol when the temperature of the skin surface reaches a predetermined threshold. EFFECT: ensured targeted photothermal therapy by means of the system. 18 cl, 8 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 770 556 C1 (51) МПК A61N 5/06 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61N 5/06 (2022.01) (21)(22) Заявка: 2020142818, 10.06.2019 (24) Дата начала отсчета срока действия патента: Дата регистрации: 18.04.2022 R U 10.06.2019 (72) Автор(ы): ФРАНЧЕСКИНА, Чезаре, Плинио (IT), ТАЛЬЯФЕРРИ, Марко (IT), ТАНГЕТТИ, Эмиль, А. (US), КАННОНЕ, Фабио (IT) (73) Патентообладатель(и): КВАНТА СИСТЕМ С.П.А. (IT) (56) Список документов, цитированных в отчете о поиске: US 2004005349 A1, 08.01.2004. US 2011160712 A1, 30.06.2011. RU 2635477 C2, 13.11.2017. RU 120008 U1, 10.09.2012. RU 137201 U1, 10.02.2014. RU 130846 U1, 10.08.2013. RU 55292 U1, 10.08.2006. US 2014121631 A1, 01.05.2014. 08.06.2018 US 62/682,597; 15.10.2018 US 62/ ...

用于靶向热调节的组合物和方法

提供了用于诸如人的哺乳动物的美容、诊断和治疗应用的纳米颗粒和制剂。

流体配給システム及び電気外科用器具コントローラ

本発明は組織を処置するためのシステムを提供するものであって、それに含まれるのは、出力測定装置、その出力測定装置と組み合わせた流量コントローラ、及び、その組織にラジオ周波数出力及び導電性流体を供給するために構成された電気外科用器具であり、ここでこの流量コントローラは、出力測定装置からの信号に基づいて、導電性流体の組織への流量を変更できるよう、構成される。本発明はまた、組織に加えられるラジオ周波数出力の測定に基づいて、導電性流体の組織への流量を変更させるための方法と器具を提供する。

A Handpiece for treatment, AN TREATMENT APPARATUS AND A METHOD FOR CONTROLLING THAT

본 발명의 실시예에 따른 치료용 핸드피스는, 선단에 적어도 하나의 관통홀이 형성된 하우징, 상기 관통홀을 통해 적어도 일부가 노출된 상태에서 조직 표면을 관통하여 조직 내부로 삽입되는 삽입부 및 상기 관통홀을 통해 상기 조직 표면으로 공급되는 냉각 가스를 제공하는 냉각 채널을 포함한다. The handpiece for treatment according to an embodiment of the present invention includes a housing having at least one through hole formed at a tip end, an insertion part that penetrates the tissue surface and is inserted into the tissue when at least a portion is exposed through the through hole, and the It includes a cooling channel for providing a cooling gas supplied to the tissue surface through the through hole.

使用皮肤表面温度测量和相关联方法的剂量测定的确定过程和预测闭环控制

公开了一种用于确定合适的参数集合的方法，所述合适的参数集合用于操作用于靶向包埋在介质中的发色团的光热靶向治疗系统内的光源。所述方法包括，在施用治疗方案之前：1）以预设功率水平向待治疗的位置施用来自光源的至少一个激光脉冲，预设功率水平在已知损伤阈值以下；2）在施用所述至少一个激光脉冲之后，测量待治疗位置处的皮肤表面温度；3）估计用于操作光源的参数和皮肤表面温度之间的关系；以及4）限定用于操作光源的参数的安全操作范围，以便避免对待治疗的位置处的介质的热损伤，同时在施用治疗方案中仍然有效地靶向发色团。

Fluid-assisted medical devices, systems and methods

Surgical devices for treating tissue are provided. Also provided are systems for treating tissue and methods of treating tissue. An exemplary surgical device has a handle, a fluid passage connectable to a fluid source, a tip portion and a distal end. The tip portion can simultaneously provide RF power and conductive fluid to tissue. The tip portion includes an electrode having a domed portion having a domed surface and a cylindrical portion having a cylindrical surface. The domed portion is located distal to the cylindrical portion and occupies at least a portion of the distal end of the surgical device. The device includes a fluid outlet opening in fluid communication with the fluid passage, the fluid outlet opening configured to provide the conductive fluid to a surface of the electrode proximal to the distal end surface of the surgical device.

Fluid-assisted medical devices, systems and methods

A medical device (5) is provided which comprises a catheter tube having a distal end and a lumen, and configured to assist in applying tamponage to a bleeding source in a gastrointestinal tract when flexed. A catheter tip having a catheter tip outer surface is assembled with the tube adjacent the distal end of the tube. The catheter tip comprises a probe body comprising an electrically insulative material, at least one electrode pair located on the probe body which comprises a first electrode spaced from a second electrode, and a fluid distribution manifold to direct a fluid from inside the probe body towards the tip outer surface. The manifold comprises a central passage within the probe body and a plurality of lateral passages which extend from the central passage towards the tip outer surface. An extendable injection needle is housed within the central passage to provide treatment to tissue.

Aesthetic method of biological structure treatment by magnetic field

In combined methods for treating a patient using time-varying magnetic field, treatment methods combine various approaches for aesthetic treatment. A magnetic field generating device is placed proximate to a body region of the patient. The magnetic field generating device generates a time-varying magnetic field with a magnetic flux density in a range of 0.5 to 7 Tesla. The time-varying magnetic field is applied to the body region of the patient in order to cause a contraction of a muscle within the body region. A second therapy may be used by applying one or more of optical waves, radio frequency waves, mechanical waves, negative or positive pressure or heat to the body region of the patient.

Fluid-assisted medical devices, systems and methods

Surgical devices, systems and methods for treating tissue are provided. An exemplary surgical device comprises a tip portion including first and second jaws each having a tissue grasping surface, at least one of the jaws being movable toward the other jaw. The tissue grasping surface of each jaw has includes an electrically insulative surface. The device also includes first and second electrodes connectable to different terminals of an RF generator to generate electrical current flow therebetween, with each of the electrodes having an electrode surface. One of the electrode surfaces is located on one of the jaws separated from one edge of the tissue grasping surface, and the other of the electrode surfaces is located on one or the other of the jaws separated from the other edge of the tissue grasping surface. The device also includes at least one fluid passage being connectable to a fluid source.

Seal & cut electrosurgical instrument

An electrosurgical instrument has a handle and a body which position and close a jaw about a tissue site for simultaneously cutting and sealing relatively large tissue structures. The jaw includes an electrosurgical cutting member, which may be a blade or wire, against which tissue is biased along a cut line, and a clamping assembly that clamps a region adjacent to or surrounding the cut line. The clamping assembly includes sealing electrodes for heating the region and welding tissue along the side of the cut as the cutter parts the tissue. The clamping assembly preferably has first and second clamping jaws extending in parallel to grip the tissue as tension is released by the cut, allowing dependable and complete sealing of the cut ends over an extended time while the tissue is immobilized. Sealing electrodes formed of thermally conductive material may be covered by a thinner coating or thermally non-impeding or heat transfer cover, which preferably includes a material to assure biocompatibility and prevent sticking. The handle, body and jaw may be configured in the shape of a hemostat to allow simple positioning, or may be configured with an elongated body and a mechanism that operates the jaw through a stationary or telescoping handle for endosurgical use through a small incision. The blade may extend entirely to the tip, or the clamp assembly may extend forward of the blade. An energy ratio input element may attach to an energy source to apportion electrosurgical energy between the cutting member and the sealing electrodes. The element may include a pair of transformers, or a transformer with a split secondary or a tapped secondary winding, with the primary configured for connection to the output of an RF scalpel drive console. The windings of the transformer match impedances and power requirements of the different cutting and sealing electrodes to coordinate effective tissue sealing and welding with the cutting operation.

Method and apparatus for carrying out the controlled heating of tissue in the region of dermis

Implant apparatus and method for effecting a controlled heating of tissue within the region of dermis of skin. The heater implants are configured with a thermally insulative generally flat support functioning as a thermal barrier. One surface of this thermal barrier carries one or more electrodes within a radiofrequency excitable circuit as well as an associated temperature sensing circuit. The implants are located within heating channels at the interface between skin dermis and the next adjacent subcutaneous tissue layer such that the electrodes are contactable with the lower region of dermis. During therapy a conformal heat sink is positioned against the skin above the implants and a slight tamponade is applied through the heat sink to assure uniform dermis contact with electrode surfaces. An adjuvant may be employed to infiltrate dermis to significantly lower the thermal threshold transition temperature for dermis or dermis component shrinkage.

Method and apparatus for controlling ablation

本发明提供了用于控制消融治疗的装置和方法。在一个实施例中，本发明提供了一种消融装置，所述消融装置包括细长本体，所述细长本体具有近端和远端、以及延伸通过其中的内部管腔。所述内部管腔可被构造以便在其中接收流体并将流体输送至所述细长本体的所述远端。所述装置还可包括消融元件，所述消融元件被定位在所述细长本体的远端处，所述消融元件被构造以便对周围组织进行加热，和被设置在所述内部管腔内与所述细长本体的远端相邻的位置处的加热器元件，所述加热器元件被构造以便对流动通过所述内部管腔的流体进行加热。

Fluid-assisted medical device, system and method

Systems, devices and methods for performing medical procedures in the intestine

A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat polycystic ovarian syndrome (PCOS).

Device and method for needle-less interstitial injection of fluid for ablation of cardiac tissue

Methods and apparatus for delivering precise amounts of fluid under pressure into cardiac tissue for the purpose of facilitating ablation of the tissue along a desired lesion line. One method injects fluid under pressure through a discharge orifice in a needle-less injection device. The injected fluid can be a cytotoxic fluid and/or a highly conductive fluid injected in conjunction with radio frequency ablation to create an ablative virtual electrode. The injected fluid can provide deeper and narrower conduction paths and resulting lesions. Radio frequency ablation can be performed at the same time as the fluid injection, using the injection device as an electrode, or subsequent to the fluid injection, using a separate device. In some methods, the injected fluid is a protective fluid, injected to protect tissue adjacent to the desired lesion line. Fluid delivery can be endocardial, epicardial, and epicardial on a beating heart. The present methods find one use in performing maze procedures to treat atrial fibrillation.

Electrosurgical jaw structure for controlled energy delivery

A working end of a surgical instrument that carries first and second jaws for delivering energy to tissue. In a preferred embodiment, at least one jaw of the working end defines a tissue-engagement plane that contacts the targeted tissue. The cross-section of the engagement plane reveals that it defines a surface conductive portion that overlies a variably resistive matrix of a temperature-sensitive resistive material or a pressure-sensitive resistive material. An interior of the jaw carries a conductive material or electrode that is coupled to an Rf source and controller. In an exemplary embodiment, the variably resistive matrix can comprise a positive temperature coefficient (PTC) material, such as a ceramic, that is engineered to exhibit a dramatically increasing resistance (i.e., several orders of magnitude) above a specific temperature of the material.

Arthroscopic surgical temperature control system

An arthroscopic surgical temperature control system and method able to monitor and control the temperature within a surgical site during arthroscopic ablation procedures in order to prevent tissue damage is provided.

Fluid assisted medical devices, fluid delivery systems and controllers for such devices, and methods

Medical devices, methods and systems for treating tissue are provided. An exemplary system comprises a fluid from a fluid source (24a) at a fluid flow rate, a surgical device (5a) which provides power and the fluid to the tissue and a control mechanism which changes a fluid flow rate provided from the surgical device and changes a power level provided from the surgical device. The fluid flow rate changes between at least two non-zero levels. An exemplary method comprises providing a fluid from a fluid source at a fluid flow rate, providing a surgical device which provides power and the fluid to the tissue, and changing the fluid flow rate of fluid provided from the surgical device with a change in power level provided from the surgical device.

Electrosurgical jaw structure for controlled energy delivery

A working end of a surgical instrument that carries first and second jaws for delivering energy to tissue. In a preferred embodiment, at least one jaw of the working end defines a tissue-engagement plane that contacts the targeted tissue. The cross-section of the engagement plane reveals that it defines a surface conductive portion that overlies a variably resistive matrix of a temperature-sensitive resistive material or a pressure-sensitive resistive material. An interior of the jaw carries a conductive material or electrode that is coupled to an Rf source and controller. In an exemplary embodiment, the variably resistive matrix can comprise a positive temperature coefficient (PTC) material, such as a ceramic, that is engineered to exhibit a dramatically increasing resistance (i.e., several orders of magnitude) above a specific temperature of the material. In use, the engagement plane will apply active Rf energy to captured tissue until the point in time that the variably resistive matrix is heated to its selected switching range. Thereafter, current flow from the conductive electrode through the engagement surface will be terminated due to the exponential increase in the resistance of variably resistive matrix to provide instant and automatic reduction of Rf energy application. Further, the variably resistive matrix can effectively function as a resistive electrode to thereafter conduct thermal energy to the engaged tissue volume. Thus, the jaw structure can automatically modulate the application of energy to tissue between active Rf heating and passive conductive heating of captured tissue to maintain a target temperature level.

Electrosurgical working end with replaceable cartridges

An electrosurgical medical device and method for creating thermal welds in engaged tissue that carries the electrosurgical components in a disposable cartridge. The instrument also can carry a blade member in a disposable cartridge, thus making the instrument system inexpensive to use. In another embodiment, the electrical leads of the cartridge have a surface coating of a thermochromic material to provide the physician with a visual indicator of operational parameters when applying energy to tissue.

Electrosurgical instrument and method of use

An electrosurgical medical device and method for creating thermal welds in engaged tissue. In one embodiment, at least one jaw of the instrument defines a tissue engagement plane carrying a variable resistive body of a positive temperature coefficient material that has a selected decreased electrical conductance at each selected increased temperature thereof over a targeted treatment range. The variable resistive body can be engineered to bracket a targeted thermal treatment range, for example about 60° C. to 80° C., at which tissue welding can be accomplished. In one mode of operation, the engagement plane will automatically modulate and spatially localize ohmic heating within the engaged tissue from Rf energy application across micron-scale portions of the engagement surface. In another mode of operation, a variable resistive body will focus conductive heating in a selected portion of the engagement surface.

Electrosurgical instrument and method

An electrosurgical instrument and method for treating varicose veins. In one embodiment, an elongate catheter has a distal working end that carries an electrosurgical energy delivery surface comprising at least one electrode with a positive temperature coefficient of resistance (PTCR) surface and/or an electrode with a pressure sensitive variable resistance to provide a smart surface for controlling Rf current flow at the interface of electrosurgical surface and the tissue. The electrode surface then can limit or modulate Rf energy delivery through the surface in response to the temperature of the surface or the engagement pressure of the surface against the engaged tissue. In operation, the smart electrosurgical surface prevents arcing at the electrode-tissue interface, and thus controls ohmic heating to prevent tissue desiccation, charring and emboli formation.

Arthroscopic surgical temperature control system

An arthroscopic surgical temperature control system and method able to monitor and control the temperature within a surgical site during arthroscopic ablation procedures in order to prevent tissue damage is provided.

Devices and methods for shaping therapy in fluid enhanced ablation

유체 강화 절제 요법에서 형성된 절제 치료 용적을 성형하기 위한 장치들 및 방법들이 제공된다. 본원에 개시된 장치들 및 방법들은 다양한 형상을 갖는 절제 치료 용적을 형성하기 위하여 유체의 상호작용을 활용한다. 하나의 실시예에서, 원하는 형상을 갖는 절제 치료 용적을 형성하기 위한 방법은 절제 치료 용적을 형성하기 위하여 치료적 에너지를 조직으로 전달하고, 제1 유체 및 제2 유체를 상기 조직으로 동시에 전달하는 것을 포함한다. 제1 및 제2 유체는 절제 치료 용적이 원하는 형상을 갖도록 치료적 에너지를 원하는 방향으로 대류 순환시킬 수 있다. Devices and methods are provided for shaping an ablation treatment volume formed in a fluid enhanced ablation therapy. The devices and methods disclosed herein utilize the interaction of fluids to form ablative treatment volumes having various shapes. In one embodiment, the method for forming an ablation treatment volume having a desired shape comprises transferring therapeutic energy to a tissue to form an ablation treatment volume, and simultaneously transferring a first fluid and a second fluid to the tissue. Include. The first and second fluids can convectively circulate therapeutic energy in a desired direction so that the ablation treatment volume has a desired shape.

Apparatus and method for carrying out remote temperature monitoring in the enhanced ablation of fluid

本发明提供了用于在流体增强型消融治疗过程中在处理体积空间内的多个位置处监控组织的温度的装置和方法。在一个实施例中，本发明提供了一种消融装置，所述消融装置具有细长本体、至少一个消融元件和至少一个温度传感器。所述细长本体包括近端和远端、内部管腔和至少一个出口端口，以便允许流体被输送至所述细长本体周围的组织。所述至少一个消融元件被构造以便对所述至少一个消融元件周围的组织进行加热。所述至少一个温度传感器可被定位在与所述至少一个消融元件相隔一定距离的位置处，且所述至少一个温度传感器可在与所述至少一个消融元件相隔一定距离的情况下有效地输出所述组织的测量温度，从而使得所述测量温度表示出所述组织是否被加热至治疗水平。

Method and apparatus for heating fluid in fluid enhanced ablation therapy

本发明披露了用于对流体增强型消融所使用的流体进行高效且再现性地加热的装置和方法。在一个实施例中，本发明提供了一种消融装置，所述消融装置具有细长本体、延伸通过所述细长本体的内部管腔的至少一根金属丝、和被设置在所述内部管腔内的至少一个间隔件。所述至少一根金属丝延伸通过所述至少一个间隔件，从而使得所述至少一个间隔件有效地保持所述至少一根金属丝的相邻部分使其与所述内部管腔呈大体上固定的几何关系，由此防止产生短路且使得可对流动通过所述细长本体的所述内部管腔的流体进行一致且均匀地加热。

Suction stabilized epicardial ablation devices

A suction assisted ablation device having a support surface, suction elements disposed adjacent the support surface, at least one electrode and at least one suction conduit is provided. The device may further include fluid openings, which allow fluid to irrigate target tissue and aid in ablation. A method for ablating tissue using suction is also provided.

Visual electrode ablation systems

Visual electrode ablation systems are described herein which include a deployment catheter and an attached imaging hood deployable into an expanded configuration. In use, the imaging hood is placed against or adjacent to a region of tissue to be imaged in a body lumen that is normally filled with an opaque bodily fluid such as blood. A translucent or transparent fluid, such as saline, can be pumped into the imaging hood until the fluid displaces any blood, thereby leaving a clear region of tissue to be imaged via an imaging element in the deployment catheter. An electric current may be passed through the fluid such that it passes directly to the tissue region being imaged and the electrical energy is conducted through the fluid without the need for a separate ablation probe or instrument to ablate the tissue being viewed.

Devices for thrombus dispersal

Methods and devices for controlling ablation therapy

本发明提供了用于控制消融治疗的装置和方法。在一个实施例中，本发明提供了一种消融装置，所述消融装置包括细长本体，所述细长本体具有近端和远端、以及延伸通过其中的内部管腔。所述内部管腔可被构造以便在其中接收流体并将流体输送至所述细长本体的所述远端。所述装置还可包括消融元件，所述消融元件被定位在所述细长本体的远端处，所述消融元件被构造以便对周围组织进行加热，和被设置在所述内部管腔内与所述细长本体的远端相邻的位置处的加热器元件，所述加热器元件被构造以便对流动通过所述内部管腔的流体进行加热。

Medical instrument with thermochromic or piezochromic surface indicators

Medical devices and methods for creating creating thermal welds in engaged tissue or fastening tissue. In one embodiment, surface portions of the jaws carry thermochromic or piezochromic materials to provide the physician with visual indications of operational parameters when applying energy to tissue. In another embodiment, the thermochromic or piezochromic materials are carried at the working end of a probe used in athroscopy to provide the physician with needed information concerning engagement of the tissue-engaging surface with the targeted tissue. In one embodiment, the chromic materials can be combined with a tissue-engaging surface that comprises a conductive-resistive matrix of a conductively-doped non-conductive elastomer.

Surgical instrument with feedback at end effector

An apparatus for operating on tissue includes a body, a lip in communication with the body, and at least one electrode also in communication with the body. The body is able to mechanically couple with a portion of an end effector, which may be controlled by a user through a handpiece. The lip is configured to grip a portion of the end effector. The at least one electrode is configured to provide sufficient electrical energy to weld at least a portion of tissue. In some versions, a temperature sensitive material may be positioned on a portion of the end effector. Additionally, in some versions, the handpiece of the end effector may comprise feedback features able to convey information to the user.

Method and systems for generating images in coherent radiation and controlling with feedback for modifying materials

Изобретение относится к способам и системам для формирования изображений в когерентном излучении и управления с обратной связью для модификации материалов и может быть использовано в процессах модификации материалов, таких как лазерная хирургия, спекание и сварка. Источник пучка для обработки материала выдает пучок для обработки материала, который подается в место расположения материала в процессе модификации материала. Оптический источник для формирования изображений выдает световое излучение для формирования изображения. Оптический интерферометр выдает выходной сигнал интерферометрии с использованием по меньшей мере компонента светового излучения для формирования изображения, которое поступает к образцу. Входной сигнал интерферометрии основывается на сравнении по меньшей мере одной длины оптического пути к образцу и другой длины оптического пути. Контроллер с обратной связью управляет по меньшей мере одним параметром обработки процесса модификации материала на основании выходного сигнала интерферометрии. Процесс модификации материала выбирают из спекания, сварки и пайки или их сочетания. Способ включает обработку интерферограмм на основании гомодинной фильтрации, генерирование записи процесса модификации материала с использованием выходного сигнала интерферометрии. В результате обеспечивается высокое качество модификации материалов за счет повышения точности управления процессом. 2 н. и 25 з.п. ф-лы, 2 табл., 48 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 760 694 C2 (51) МПК B23K 26/03 (2006.01) B23K 26/06 (2014.01) B23K 26/144 (2014.01) B23K 26/20 (2014.01) B23K 26/342 (2014.01) B23K 26/38 (2014.01) ФЕДЕРАЛЬНАЯ СЛУЖБА B33Y 10/00 (2015.01) ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ G01B 9/02 (2006.01) (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК B23K 26/20 (2021.08); B23K 26/342 (2021.08); B23K 26/38 (2021.08); B33Y 10/00 (2021.08); G01B 9/02 (2021.08) (21)(22) Заявка: 2019122333, 18.01.2018 18.01.2018 Дата регистрации: Приоритет(ы): (30) Конвенционный приоритет: 18.01. ...

System and method convenient for applying thermal dose appropriate in microwave ablation program

根据本公开提供了一种微波消融系统，其包括：微波消融探针，其被配置成在消融程序期间将能量输送到组织的目标体积；至少一个温度传感器，其被配置成在消融程序期间在多个时间点处确定组织的目标体积的温度；以及计算装置，其可操作地耦合到所述微波消融探针和所述至少一个温度传感器。所述计算装置包括处理器和存储指令的存储器，所述指令使计算装置加载与组织的目标体积相对应的温度累积曲线，并根据组织的目标体积在每个时间点处的温度动态地控制微波消融探针，使得组织的目标体积的温度在消融程序期间遵循温度累积曲线。

Methods and Devices for Use of Degassed Fluids with FLUID Enhanced ABLATION DEVICES

본 발명은 절제 치료법 과정에서 치료 부위에 유체를 적용하기 이전에 유체로부터 가스를 제거하기 위한 장치들, 시스템들 및 방법들을 제공한다. 한 가지 구체예에서, 절제 시스템은 길쭉한 본체, 절제 부재, 가열 어셈블리, 및 유체 공급원을 포함할 수 있다. 유체 공급원 중의 유체는 시스템의 일부로서 제공되기 이전에 최소한 부분적으로 가스제거될 수 있거나, 일부 구체예들의 경우 상기 치료 부위에 유체를 적용하기 이전에 시스템 내에서 유체로부터 가스를 제거하도록 구성된 가스제거 장치가 제공될 수 있다. 가스제거 장치는 그 내부에 배치되어 있는 하나 이상의 기체-투과성이면서 유체-불투과성인 튜브를 포함하여 기체가 상기 장치를 통해 흐르는 유체로부터 제거되는 것을 허용할 수 있다. 다른 예시적 장치들, 시스템들 및 방법들이 또한 제공된다. The present invention provides devices, systems, and methods for removing gas from a fluid prior to applying the fluid to a treatment site in the course of an ablation therapy. In one embodiment, the ablation system can include an elongated body, an ablation member, a heating assembly, and a fluid source. The degassing device may be at least partially degassed before being provided as part of the system, or in some embodiments configured to remove gas from the fluid within the system prior to applying the fluid to the treatment site. May be provided. The degassing device may include one or more gas-permeable and fluid-impermeable tubes disposed therein to allow gas to be removed from the fluid flowing through the device. Other example devices, systems, and methods are also provided.

Dermatological laser systems and methods for treatment of tissue with poor chromophore selectivity

Dermatological systems and methods for providing a therapeutic laser treatment of tissue having poor chromophore selectivity using a laser source having a grating element to provide laser light having reduced linewidth. In some embodiments, the linewidth is reduced by at least half compared to the linewidth that would be provided in a system without the grating filter element. The linewidth may be reduced in some cases to 500 GHz or less, 300 GHz or less, or 200 Hz or less.

Compositions and methods for targeted thermomodulation

Methods and devices for heating fluid in fluid enhanced ablation therapy

본 발명은 유체 증강 절제에서 사용하기 위한 유체를 효율적이고 재생가능하게 가열하는 장치 및 방법에 관한 것이다. 한 가지 구체예에 따르면, 길쭉한 본체, 상기 길쭉한 본체의 내부 루멘을 관통해 뻗어 있는 하나 이상의 와이어, 및 상기 내부 루멘 내부에 배치된 하나 이상의 스페이서를 포함하는 절제 장치가 제공된다. 상기 하나 이상의 와이어는 상기 하나 이상의 스페이서를 관통하여 뻗어 있어, 상기 하나 이상의 스페이서가 상기 하나 이상의 와이어의 인접 부분이 상기 내부 루멘과 실질적으로 고정된 기하학적 관계를 효과적으로 유지시킴으로써, 누전을 방지하고 상기 길쭉한 본체의 내부 루멘을 통해 흐르는 유체를 일정하고 균일하게 가열하게 된다. The present invention relates to an apparatus and method for efficiently and reproducibly heating a fluid for use in fluid reinforcement ablation. According to one embodiment, an ablation apparatus is provided that includes an elongated body, one or more wires extending through an inner lumen of the elongated body, and one or more spacers disposed inside the inner lumen. The one or more wires extend through the one or more spacers, such that the one or more spacers effectively maintain a geometric relationship in which adjacent portions of the one or more wires are substantially fixed with the inner lumen, thereby preventing short circuits and the elongated body. The fluid flowing through the inner lumen of the is heated uniformly and uniformly.

A system for treating unwanted tissue

Compositions and methods for targeted thermomodulation

Automated therapy of a three-dimensional tissue region

In an embodiment, a method for effecting thermal therapy using an in vivo probe includes positioning the probe in a volume in a patient, identifying an irregularly shaped three-dimensional region of interest and automatically applying thermal therapy to the region using the probe. Applying thermal therapy may include identifying a first emission level at a first rotational angle based in part on a depth of a radial portion of the region in the direction of probe emission, activating emission of the probe, causing rotation of the probe to a next rotational angle, identifying a next emission level at the next rotational angle based in part on a depth of a radial portion of the region in the direction of probe emission, activating emission to deliver therapeutic energy, and repeating rotation and emission until therapeutic energy has been delivered to the volume.

Method and system for coherent imaging and the feedback control for material modification

提供了在例如手术激光、烧结和焊接应用的材料改性工艺的背景下使用光学干涉测量法的方法和系统。一种产生成像光的成像光源。反馈控制器基于使用成像光产生的干涉测量输出来控制材料改性工艺的至少一个加工参数。提供了一种基于零差滤波的处理干涉图的方法。提供了一种使用干涉测量输出生成材料改性工艺的记录的方法。

Thermal treatment of the skin surface with metal nanoparticles in surfactant containing solutions

Treatment of skin tissue with photoactive materials and light, such as nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans. In particular, embodiments of thermal treatment of the skin surface with metal nanoparticles in surfactant containing solutions are disclosed.

Devices and methods for shaping therapy in fluid enhanced ablation

本发明提供了形成于流体增强消融治疗中用于塑形消融处理体积的装置和方法。本文所公开的装置和方法利用流体的相互作用以产生具有各种形状的消融处理体积。在一个实施例中，一种用于形成具有期望形状的消融处理体积的方法，包括输送治疗能至组织以形成消融处理体积并且同时输送第一流体和第二流体至组织。第一和第二流体可沿期望的方向对流传递治疗能使得消融处理体积具有期望的形状。

Methods and devices for use of degassed fluids with fluid enhanced ablation devices

Compositions and methods for targeted thermomodulation

A topical cosmetic composition for use in cosmetic, diagnostic and therapeutic procedures wherein the composition comprises a cosmetically acceptable carrier and a plurality of plasmonic nanoparticles in an amount effective to induce thermomodulation in a target tissue region with which the composition is topically contacted.

Polymers, thermochromic agents, and/or hydrogel compositions and apparatus, including products embodying the same, and methods and processes for making same

EXTRACTION-STABILIZED EPICARDIAL ABLATION DEVICES

Determination process and predictive closed-loop control of dosimetry using measurement of skin surface temperature and associated methods

매질에 매립된 색소포를 타겟팅하기 위해 광열 타겟 치료 시스템 내에서 광원을 동작시키기 위한 적절한 한 세트의 파라미터들을 결정하기 위한 방법이 개시된다. 방법은, 치료 프로토콜의 시행 전에: 1) 미리 설정된 전력 레벨에서 광원으로부터의 적어도 하나의 레이저 펄스를 치료될 위치에 시행하는 단계 ― 미리 설정된 전력 레벨은 알려진 손상 임계치 미만임 ― ; 2) 적어도 하나의 레이저 펄스의 시행 다음에, 치료될 위치에서 피부 표면 온도를 측정하는 단계; 3) 광원을 동작시키기 위한 파라미터들과 피부 표면 온도 사이의 관계를 추정하는 단계; 및 4) 치료 프로토콜을 시행할 때, 색소포를 효과적으로 여전히 타겟팅하면서, 치료될 위치에서 매질에 대한 열 손상을 피하기 위해, 광원을 동작시키기 위한 파라미터들에 대한 안전한 동작 범위를 정의하는 단계를 포함한다. A method for determining an appropriate set of parameters for operating a light source within a photothermal target therapy system to target chromatophores embedded in a medium is disclosed. The method includes, prior to implementation of the treatment protocol: 1) applying at least one laser pulse from a light source at a preset power level to the location to be treated, wherein the preset power level is below a known damage threshold; 2) following the administration of at least one laser pulse, measuring the skin surface temperature at the location to be treated; 3) estimating the relationship between the parameters for operating the light source and the skin surface temperature; and 4) defining safe operating ranges for parameters for operating the light source to avoid thermal damage to the medium at the location to be treated, while effectively still targeting the chromatophores when implementing the treatment protocol. .

Methods and devices for use of degassed fluids with fluid enhanced ablation devices

Devices, systems, and methods for degassing fluid prior to applying fluid to a treatment site during ablation therapy are provided. In one embodiment, an ablation system can include an elongate body, an ablation element, a heating assembly, and a fluid source. Fluid in the fluid source can be at least partially degassed prior to being provided as part of the system, or, in some embodiments, a degassing apparatus can be provided that can be configured to degas fluid within the system prior to applying the fluid to the treatment site. The degassing apparatus can include one or more gas-permeable and fluid-impermeable tubes disposed therein, which can allow gas to be removed from fluid passing through the apparatus. Other exemplary devices, systems, and methods are also provided.

Method and apparatus for treating soft tissue injury

System for out of bore focal laser therapy

The present invention provides methods of determining cancer margins indicating the location and breadth of treatment necessary for the elimination of cancerous tissue during focal laser therapy. The present invention also provides systems and devices for focal laser therapy, and methods for using the same. The present invention does not rely on MRI thermometry, improving accuracy of treatment while also reducing treatment time and cost.

Methods and devices for heating fluid enhanced ablation therapy

Devices and methods for efficiently and reproducibly heating fluid for use in fluid enhanced ablation are disclosed herein. In one embodiment, an ablation device is provided having an elongate body, at least one wire extending through an inner lumen of the elongate body, and at least one spacer disposed within the inner lumen. The at least one wire extends through the at least one spacer such that the at least one spacer is effective to maintain an adjacent portion of the at least one wire in a substantially fixed geometric relationship with the inner lumen, thereby preventing electrical shorts and providing for the consistent and uniform heating of fluid flowing through the inner lumen of the elongate body.

Robot-assisted laser surgery system

一种用于处理生物组织的系统，所述系统包括：工具，其包括可操作以执行至少一个处理动作的激光器；定位构件，其用于相对于所述生物组织定位所述工具以执行所述至少一个处理动作；控制器；存储装置，其存储用于控制所述控制器的电子程序指令；以及输入构件；其中所述控制器可在所述电子程序指令的控制下操作以：经由所述输入构件接收输入；处理所述输入，且基于所述处理，控制所述定位构件和所述工具来处理所述生物组织。

Bipolar electrosurgical features for targeted hemostasis

An apparatus is configured to operate on tissue. The apparatus includes an end effector with an upper jaw and a lower jaw. The upper jaw is configured to pivot relative to the lower jaw. The apparatus also includes an electrode cap coupled to either the upper or lower jaw. The electrode cap includes a first electrode surface configured at a first polarity and a second electrode surface configured at a second polarity. The second polarity is opposite to the first polarity. The electrode cap is configured to be applied to tissue such that the electrode cap is operable to deliver bipolar RF energy to the tissue. The electrode cap may be used to selectively weld bleeding tissue in a localized fashion, without having to place the tissue between the jaws, and without having to use an instrument separate from the jaws.

Method and apparatus for carrying out the controlled heating of tissue in the region of dermis

A handheld device for performing a treatment operation on skin

According to an aspect, there is provided a handheld device ( 2 ) for applying energy pulses to skin ( 17 ) of a subject to perform a treatment operation as the handheld device is moved across the skin, the handheld device comprising: an aperture ( 6 ) that is to be placed adjacent to the skin; at least one energy source ( 8 ) for generating an energy pulse and for providing the energy pulse through the aperture to perform the treatment operation on 5 skin adjacent the aperture, wherein the at least one energy source has a minimum pulse repetition period following the generation of an energy pulse before a subsequent energy pulse can be generated; a first skin property sensor ( 14 ) for measuring a skin property and for outputting a first measurement signal representing measurements of the skin property at a first sensing position ( 24 ), wherein the skin property is a property that changes in response to the application of an energy pulse to the skin, and wherein the first sensing position is in front of the aperture relative to an intended motion direction of the handheld device over the skin; a second skin property sensor ( 16 ) for measuring the skin property and for outputting a second measurement signal representing measurements of the skin property at a second sensing position ( 26 ), wherein the second sensing position is behind the aperture relative to the intended motion direction; a memory unit ( 56 ); and a control unit ( 10 ) that is coupled to the at least one energy source to control the generation of energy pulses by the at least one energy source, and coupled to the first skin property sensor and the second skin property sensor to obtain the first measurement signal and the second measurement signal, wherein the control unit is configured to store a profile of at least the first measurement signal in the memory unit; wherein the control unit is further configured to, when the handheld device is moving in the intended motion direction over the skin: ...

Bladder temperature measurement for high intensity focused ultrasound

Methods and systems for blocking neural activity in an organ of a subject, preferably in the small intestine or the duodenum

Compositions and methods for targeted thermomodulation

COMPOSITIONS AND METHODS FOR TARGETED THERMOMODULATION Provided are nanoparticles and formulations which are useful for cosmetic, diagnostic and therapeutic applications to mammals such as humans.

Systems, devices, and methods for optically clearing tissue

Fluid assisted medical devices, fluid delivery systems and controllers for such devices, and methods

Ablation system

Systems, devices, and methods for optically clearing tissue

Embodiments of the present disclosure provides systems, devices, and methods for non-invasively modifying, maintaining, or controlling local tissue optical properties. Methods and devices of the disclosure may be used for optically clearing tissue, for example, for diagnostic and/or therapeutic purposes. A method of optically clearing a tissue may comprise contacting the tissue with an optical clearing device having a base, an array of pins fixed to one side of the base, a brim fixed to the base, an inlet port in the base, an exit port in the base, and a handpiece interface tab fixed to the side of the base opposite the array of pins, applying a mechanical force to the tissue, and illuminating said tissue with at least one wavelength of light through the optical clearing device. A method may further comprise controlling the temperature of the tissue illuminated.

Thermochromic polyacrylamide tissue phantom and its use for evaluation of ablation therapies

A polyacrylamide tissue phantom embedded with multi-formulated thermochromic liquid crystals for use in the evaluation of RF ablation therapies is provided. The tissue phantom approximates the properties of biological tissue, and therefore provides a suitable substitute for use in testing the effects of RF and other energy-emitting devices on biological tissue. Also provided is a system for using the tissue phantom in the evaluation of RF therapies.

Systems, devices and methods for performing medical procedures in the intestine

A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat polycystic ovarian syndrome (PCOS).

Guided thrombus dispersal catheter

Catheter systems of the invention involve guided and informed dissolution of occlusions in blood vessels. According to certain aspects, a catheter system of the invention includes an elongate body defining a first lumen and comprising a distal portion, an inner member configured for insertion into the first lumen, the inner member comprising an energy source configured to deliver therapeutic energy to a treatment site, and an imaging assembly located at the distal portion of the elongate body. In some embodiments, the catheter system includes a functional flow sensor in addition to or as an alternative to the imaging assembly.

Surgical laser system

A thulium fiber laser system can be used to treat tissues based on the ability for quick changes between laser pulses. For example, to treat stones in a tissue, a long pulse having low peak power can be used to create bubbles in front of the stone (calculi), then follow a series of shorter pulses and higher peak power can be used to break the stone. The sequence can be repeated to maintain large bubble formation, with the long pulse characteristics changed to accommodate for the changes in the tissue. A fluorescent sensing assembly can be used to detect the tissue conditions for selecting the conditions of the thulium fiber laser.

Skin treatment apparatus and method

A method and system for aesthetic skin treatment. The system includes a treatment energy source for generating a treatment beam and a treatment beam deflecting mechanism configured to direct the treatment beam to a treated skin area. One or more video cameras configured to capture a treated skin area and communicate captured treated skin area image to a processor. Based on a captured treated skin area the processor constructs a three-dimensional representation of the captured skin area and controls a treatment energy beam deflecting mechanism to deflect the treatment energy beam to follow the three-dimensional representation of the captured skin area.