ОФТАЛЬМОЛОГИЧЕСКИЕ ЛИНЗЫ С СИСТЕМОЙ КОНТРОЛЯ ВАСКУЛЯРИЗАЦИИ СЕТЧАТКИ

Группа изобретений относится к области медицины. Устройство офтальмологической линзы с энергообеспечением и с системой контроля васкуляризации сетчатки содержит: несущую вставку, содержащую переднюю и заднюю криволинейные дугообразные поверхности, причем передняя криволинейная и задняя криволинейные дугообразные поверхности формируют полость, способную содержать источник энергии, имеющий размеры в соответствии с площадью внутри полости, причем источник энергии электрически соединен и способен обеспечивать энергией микропьезоэлектрический элемент с электронной схемой обратной связи и контроллером, причем контроллер содержит вычислительный процессор, осуществляющий цифровую связь с цифровым устройством хранения данных, и причем в цифровом устройстве хранения данных хранится программный код; передатчик, находящийся в логической связи с процессором, а также в логической связи с сетью передачи данных, причем программное обеспечение выполняется по запросу и позволяет процессору: принимать данные ...

СИСТЕМА И РУЧНОЙ ЗОНД ДЛЯ НЕИНВАЗИВНОГО АНАЛИЗА В РЕЖИМЕ РЕАЛЬНОГО ВРЕМЕНИ ТКАНЕЙ ТЕЛА

Группа изобретений относится к анализу и обнаружению тканей тела с помощью ядерного магнитного резонанса (ЯМР). Система для неинвазивного анализа ткани содержит неферромагнитный ручной зонд, выполненный с возможностью установления различия между нервами, мышцами и кровеносными сосудами. Источник магнитного поля в зонде возбуждает однородное неизменяемое во времени магнитное поле в пределах объема ткани и содержит катушку индуктивности, которая принимает сигналы ВЧ-возбуждения в конкретном диапазоне частот, относящемся к напряженности магнитного поля, таким образом генерируя сигналы возбуждения, проходящие перпендикулярно направлению линий магнитного поля, и намагничивая срез живой ткани, характеризующийся глубиной и толщиной, обусловленными напряженностью поля, при этом только живая ткань в каждом срезе генерирует отклик на сигналы ядерного спинового эха. Блок управления генерирует временные шаблоны сигналов возбуждения и получает данные, характеризующие сигналы ядерного спинового эха, ...

УСТРОЙСТВО, СИСТЕМА ВИЗУАЛИЗАЦИИ И СПОСОБ КОРРЕКЦИИ МЕДИЦИНСКОГО ИЗОБРАЖЕНИЯ МОЛОЧНОЙ ЖЕЛЕЗЫ

Группа изобретений относится к устройству и способу для коррекции медицинского изображения молочной железы, а также к системе визуализации. Устройство для коррекции медицинского изображения молочной железы содержит блок ввода медицинского изображения, потенциально демонстрирующего искусственные деформации молочной железы, блок ввода отсканированного изображения, изображающего молочную железу в заданном положении субъекта и содержащего информацию о поверхности молочной железы, блок моделирования для формирования смоделированного медицинского изображения молочной железы, при этом смоделированное медицинское изображение изображает молочную железу в том же заданном положении субъекта, что и отсканированное изображение, и представляет поверхность молочной железы поверхностной сеткой, а блок моделирования выполнен с возможностью формирования смоделированного медицинского изображения молочной железы на основе волюметрической биомеханической модели, материальные параметры которой изменяемы для ...

ПРЕДСТАВЛЕНИЕ МУЛЬТИМОДАЛЬНЫХ ПОДМНОЖЕСТВ НА ОСНОВЕ ЛОКАЛЬНОЙ ВИЗУАЛИЗАЦИИ

Изобретение относится к области визуализации данных. Технический результат – обеспечение улучшенной визуализации внутренних частей тела путем отображения визуальных характеристик для разных участков части тела. Способ отображения визуальных характеристик включает этапы, на которых: получают первый набор биометрических данных первой модальности для первого участка части тела; определяют первые визуальные характеристики на основе первого набора биометрических данных; получают второй набор биометрических данных второй модальности для второго участка части тела, при этом второй участок части тела представляет собой подмножество первого участка части тела; определяют вторые визуальные характеристики на основе второго набора биометрических данных; предоставляют на дисплей первый вид, включающий первый участок части тела, отображаемый с первыми визуальными характеристиками, и второй вид, включающий второй участок части тела, отображенный со вторыми визуальными характеристиками, при этом второй ...

УСТРОЙСТВО И СПОСОБ ТЕРМИЧЕСКОГО ФОРМИРОВАНИЯ ИЗОБРАЖЕНИЙ ЧАСТИ ТЕЛА ЖИВОГО МЛЕКОПИТАЮЩЕГО

Группа изобретений относится к медицинской технике. Устройство для получения тепловых изображений части тела живого млекопитающего содержит поверхностную структуру накопления тепловой энергии для контакта с указанной частью тела, термодатчик для получения тепловых изображений, отражающих накопление тепловой энергии по меньшей мере на части указанной поверхностной структуры накопления тепловой энергии в регистрационном режиме работы указанного устройства, модуль передачи тепловой энергии для передачи тепловой энергии в указанную поверхностную структуру накопления тепловой энергии для ее приведения к опорной температуре в калибровочном режиме работы указанного устройства. Схема управления выполнена с возможностью контроля наличия части тела на указанной поверхностной структуре накопления тепловой энергии и управления передачей тепловой энергии модулем передачи тепловой энергии в калибровочном режиме при наличии части тела на поверхностной структуре накопления тепловой энергии для ограничения ...

СИСТЕМА И СПОСОБ ДЛЯ ОБНАРУЖЕНИЯ ГАЛИТОЗА

System zum patientenspezifischen Modellieren von Blutfluss

System zum Bestimmen von kardiovaskulären Informationen für einen Patienten, wobei das System Folgendes umfasst: wenigstens ein Computersystem, das konfiguriert ist, um: patientenspezifische Daten bezüglich einer Geometrie einer anatomischen Struktur des Patienten zu empfangen, wobei die anatomische Struktur wenigstens einen Abschnitt einer Mehrzahl an Koronararterien, die von einer Aorta ausgehen, beinhaltet; basierend auf den patientenspezifischen Daten ein dreidimensionales Modell zu erzeugen, das einen ersten Abschnitt der anatomischen Struktur repräsentiert, wobei der erste Abschnitt der anatomischen Struktur wenigstens den Abschnitt der Mehrzahl an Koronararterien beinhaltet; wenigstens teilweise basierend auf einer Masse oder einem Volumen des Myokardgewebes ein physikbasiertes Modell bezüglich einer Blutflusseigenschaft im ersten Abschnitt der anatomischen Struktur zu erzeugen; und wenigstens teilweise basierend auf dem dreidimensionalen Modell und dem physikbasierten Modell eine ...

Apparatus and method for detecting a presence of cancer

A diagnostic apparatus (20) and method for detecting a presence of breast cancer in a patient disposed in a testing position. The diagnostic apparatus (20) includes a housing (44) and a camera assembly (58) that is supported by the housing (44) for recording images of the breasts of the patient. A rail (76) is supported by and extends from the housing (44) and terminates at a pair of rail ends (80). A trolley (88) interconnects the camera assembly (58) and the rail (76) and is slideable along said rail (76) for providing movement of the camera assembly (58) along the rail (76) between the rail ends (80) for allowing the camera assembly (58) to consecutively record images at different positions along the rail (76) and to capture images of the lymph nodes when the camera assembly (58) is disposed adjacent to the rail ends (80) in alignment with the sides of the breasts of the patient ...

Ocular assessment

OPEN EQUIPMENT FOR THE MAGNETIC RESONANCE PICTURE GIVING

A METHOD FOR GENERATING FEMORAL X-RAY FILMS BASED ON DEEP LEARNING AND DIGITAL RECONSTRUCTION OF RADIOLOGICAL IMAGE

The invention provides a method for generating femoral X-ray films based on deep learning and digital reconstruction of radiological images, which comprises the following steps: performing deep multi-task regression through a three-dimensional convolution neural network model, automatically extracting CT slices containing trochanter and femoral medial and lateral condyles, segmenting images of femoral trochanter medial and lateral condyles by using a conditional generation antagonistic neural network, performing three-dimensional surface reconstruction on the two areas, calculating the vertices of trochanter and femoral medial and lateral condyles by calculating Gaussian curvature, After calculating the angle between the plane of three points and the horizontal plane, the final angle that needs to be rotated and corrected is obtained. By digitally reconstructing the radiological image, the X ray film analog image at the best position is obtained, replacing the film image used by the traditional ...

A method and system for cosmetic recommendations

There is provided a cosmetic method for scoring and assigning codes for a person's skin. The cosmetic method involves dividing a person's skin into a plurality of zones; evaluating zones predetermined skin characteristics in each zone; scoring the zones on a predetermined scale of scores for each predetermined skin characteristic based on the evaluation; determining a collective score wherein the scores for each zone for the predetermined skin characteristic is combined; and assigning a skin status quo code by utilising the collective score for each predetermined skin characteristic.

System and method for imaging the reflectance of a substrate

The present application discloses a system and method for the comprehensive monitoring of the microcirculation in order to assess the ultimate efficacy of the cardiovascular system in delivering adequate amounts of oxygen to the organ cells. The system utilizes reflectance avoidance by reflectance filtering, such as OPS imaging or Mainstream Dark Field imaging, or by Sidestream Dark Field imaging, which utilizes external direct light on the tip of the light guide to achieve reflectance avoidance whereby incident and reflected light do not travel down the same pathway. The system can combine reflectance avoidance with other imaging modalities to provide information regarding perfusion, oxygen saturation and oxygen availability, The system can image the reflectance of a substrate and may include a light source, a light transport body configured to project light from the light source to an examination substrate and transmit light reflected by the examination substrate, and an analysis section ...

Methods and compounds for the diagnosis and treatment of

The present invention provides for methods for use in the diagnosis and prognosis of cancer. The invention further provides to binding agents and kits for us e.g., in such methods. The present invention further relates to compositions, methods of making said compositions and methods of using the same, including use in the treatment and diagnosis of cancer, including lung, lymphoma, liver, thyroid and bladder cancer. Compositions of the present invention useful in the treatment of cancer include antisense and small inhibitory RNAs (siRNA).

Method of deriving threshold values for identifying melanonychia striata

A method of deriving threshold values for identifying melanonychia striata includes: a first step of regarding a colour image of melanonychia striata as a three-dimensional vector whereof the components are the RGB parameters of each pixel, and finding the angle made by this three-dimensional vector with a reference vector; a second step of finding the probability of occurrence of pixels having an angle found in the first step; and a third step of finding a parameter threshold value that makes it possible to identify malignancy/benignity of melanonychia striata from the probability of occurrence found in the second step.

Automated renal evaluation systems and methods using MRI image data

Renal screening systems include a circuit configured to electronically analyze MRI image data of a subject to evaluate renal function and generate a renal-risk report for a plurality of different therapeutic agents based on renal responses to test doses of each of the agents.

Method and system for patient-specific modeling of blood flow

C:\Users\kll\AppData\Local\Temp12713 IDAOBAFC.DOCX-22 12/2015 Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Membrane-based foot imaging apparatus including a camera for monitoring foot positioning

A foot imaging apparatus includes a support structure and a flexible membrane suspended from the support structure and configured to receive a foot thereon. The apparatus also includes a three-dimensional imager located under the flexible membrane and configured to acquire a topographical plantar image of the foot on the flexible membrane. The apparatus further includes a monitoring unit for monitoring a monitored region in order to evaluate a positioning of the foot on the flexible membrane. The monitoring unit includes a camera having a field of view, and at least one light deflector arranged to deflect light from the monitored region into the field of view of the camera. The camera acquires a monitoring image of the monitored region after deflection by the at least one light deflector. The monitoring image contains information about the positioning of the foot on the flexible membrane. A foot imaging method is also provided.

Method and system for patient-specific modeling of blood flow

Abstract A system for determining cardiovascular information for a patient, the system comprising: at least one computer system configured to: receive patient specific data regarding a geometry of an anatomical structure of the patient; create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, the three-dimensional model representing at least one fluid flow inlet and at least one fluid flow outlet; create at least one boundary condition model representing fluid flow through at least one of the at least one inlet or the at least one outlet, based at least in part on modeling a condition of hyperemia; and determine first information regarding a blood flow characteristic within the anatomical structure of the patient based on the three dimensional model and the at least one boundary condition model. cCD Co co VC C C) C) f I co C, Loij 0~ u~ EtIt C3oI ...

AN ARTIFICIAL INTELLIGENCE BASED SYSTEM FOR DETECTION OF COVID INFLUENCE ON HUMAN SKIN

AN ARTIFICIAL INTELLIGENCE BASED SYSTEM FOR DETECTION OF COVID INFLUENCE ON HUMAN SKIN The present invention relates to an artificial intelligence based system for detection of covid influence on human skin. The developed system comprises of reading RGB images from the patient, pre-processing of acquired images, segmentation of processed images and developing active contour images characterized in that said pre-processing method comprises of Gaussian and Median filters, segmentation method comprises of generating histograms using Hue, Saturation and Value factors in a numerical computing environment. AWASIdadW fill * .a W4 mi 4 Fiur I accupepuain fs f n pepe muwaI.SidV * I I *auaio 4si rUu fa aw o ai u n Gasilerm fmehl-mvlehI oi * S I * E tkadhueiuwion 4ofHu. atro a nd VH~alueI P* sMn adi A ctveae"u iwwmlhivsi ftaedge Figure12 ...

SYSTEM AND METHOD FOR IMAGING THE REFLECTANCE OF A SUBSTRATE

The present application discloses a system and method for the comprehensive monitoring of the microcirculation in order to assess the ultimate efficacy of the cardiovascular system in delivering adequate amounts of oxygen to the organ cells. The system utilizes reflectance avoidance by reflectance filtering, such as OPS imaging or Mainstream Dark Field imaging, or by Sidestream Dark Field imaging, which utilizes external direct light on the tip of the light guide to achieve reflectance avoidance whereby incident and reflected light do not travel down the same pathway. The system can combine reflectance avoidance with other imaging modalities to provide information regarding perfusion, oxygen saturation and oxygen availability, The system can image the reflectance of a substrate and may include a light source, a light transport body configured to project light from the light source to an examination substrate and transmit light reflected by the examination substrate, and an analysis section ...

MEMBRANE-BASED FOOT IMAGING APPARATUS INCLUDING A CAMERA FOR MONITORING FOOT POSITIONING

A foot imaging apparatus includes a support structure and a flexible membrane suspended from the support structure and configured to receive a foot thereon. The apparatus also includes a three-dimensional imager located under the flexible membrane and configured to acquire a topographical plantar image of the foot on the flexible membrane. The apparatus further includes a monitoring unit for monitoring a monitored region in order to evaluate a positioning of the foot on the flexible membrane. The monitoring unit includes a camera having a field of view, and at least one light deflector arranged to deflect light from the monitored region into the field of view of the camera. The camera acquires a monitoring image of the monitored region after deflection by the at least one light deflector. The monitoring image contains information about the positioning of the foot on the flexible membrane. A foot imaging method is also provided.

"DIAGNOSING REFLUX DISEASE"

ABSTRACT A method (100) and system (1) for diagnosing reflux disease in an individual (3). The method (100) comprises: administering (110) an oral dose (17) of tracer in to the individual; capturing )120), with a single photon emission computed tomography (SPECT) scanner (5), data representative of multiple image frames (21) of the individual in areas of interest (23) that include the pharynx (25) and oesophagus (27), wherein the data representative of multiple image frames (21) are captured over time after administration of the oral dose; and determining (130) one or more trend(s) in tracer activity over time in the areas of interest (23) based on the data representative of multiple image frames (21),wherein the trend(s) in tracer activity over time is indicative of a reflux disease.

METHOD AND APPARATUS FOR PROVIDING A QUANTITATIVE VOLUMETRIC MAP OF AN ORGAN OR AN ASSESSMENT OF ORGAN HEALTH

A method of providing a quantitative volumetric assessment of organ health or a quantitative map of an organ. The method comprises obtaining a volumetric map of organ health comprising information defining a state of tissue health across at least part of an organ, receiving an input defining at least one organ section, determining an assessment organ volume based at least partly on the at least one defined organ section, calculating an organ-viability measure for the assessment organ volume based at least partly on information within the volumetric map defining the state of tissue health across the organ volume, and outputting an indication of the organ-viability measure.

BIOMECHANICAL DEVICE FOR MEASURING VESSELS AND FOR VOLUMETRIC ANALYSIS OF LIMBS

L'invention concerne un système non vulnérant de caractérisation biomorphologique d'un membre humain (110) comprenant un dispositif de mesures géométriques et volumétriques (100) comprenant : - une pluralité de systèmes d'acquisition d'images tridimensionnelles (131-137) agencés pour imager ledit membre (110), - un cadre articulé et motorisé (120), agencé pour positionner et déplacer au moins une partie de la pluralité de systèmes d'acquisition (131-137) de manière périphérique audit membre (110), - un dispositif de traitement des données géométriques et volumétriques, agencé pour représenter les données d'acquisition sous la forme d'une pluralité de points présentant un jeu de coordonnées dans un référentiel tridimensionnel, - un dispositif de mesures biomécaniques comprenant un porte-sonde (200) agencé pour relier solidairement au moins une sonde échographique (210) pour imager le système vasculaire relatif audit membre (110) et un capteur de force (220) agencé pour mesurer la pression ...

SYSTEMS AND METHODS FOR ANATOMY-BASED REGISTRATION OF MEDICAL IMAGES ACQUIRED WITH DIFFERENT IMAGING MODALITIES

Systems and methods for co-registering medical images obtained with different imaging modalities are provided. For instance, images obtained with x-ray imaging, such as x-ray computed tomography ("CT"), can be co-registered with images obtained with magnetic resonance imaging ("MRI"). The different imaging modalities generate images that have different visualization characteristics for tissues; thus, in general, co- registration is accomplished by identifying different anatomical features in the different images and then utilizing a known spatial relationship between those anatomical features to co-register the different images.

SPINAL CORD FUNCTION ASSESSMENT

A device, system and methods are described for stimulating multiple dermatones on a body in accordance with a stimulation pattern. Magnetic resonance images are captured during the application of the stimulation pattern and the captured images are processed. The images are processed using information about the applied stimulation pattern to assess spinal cord function.

혈관 불안정 질환의 치료 및 예방 방법

... 템폴, 콜레칼시페롤, 이들의 유도체, 이들의 약학적으로 허용 가능한 염, 또는 이들의 조합을 투여함으로써 대뇌 해면 기형(cerebral cavernous malformation, CCM)과 같은 혈관 불안정 질환을 치료하고 예방하기 위한 방법이 개시된다. 적어도 하나의 대뇌 해면 기형(CCM) 병변을 갖거나 CCM 병변이 발생할 위험이 있는 환자에서 CCM 병변의 수를 감소시키기 위한 방법이 개시된다. 적어도 하나의 대뇌 해면 기형(CCM) 병변을 갖거나 CCM 병변이 발생할 위험이 있는 환자에서 CCM 병변의 수의 성장률을 감소시키기 위한 감소시키기 위한 방법이 개시된다. 적어도 하나의 대뇌 해면 기형(CCM) 병변을 갖는 환자에서 CCM의 징후 또는 증상을 예방하거나 치료하기 위한 방법이 개시된다. 적어도 하나의 대뇌 해면 기형(CCM) 병변을 갖거나 CCM 병변이 발생할 위험이 있는 환자에서 뇌혈관 염증을 감소시키거나, 뇌혈관 투과성을 감소시키거나, 또는 이 둘을 감소시키기 위한 방법이 개시된다. 대뇌 해면 기형(CCM) 병변을 갖거나 CCM 병변이 발생할 위험이 있는 환자에서 뇌혈관 건강을 개선시키기 위한 방법이 개시된다.

SYSTEM, IMAGING SUITE, AND METHOD FOR USING AN ELECTRO-PNEUMATIC INSUFFLATOR FOR MAGNETIC RESONANCE IMAGING

Embodiments of the invention provide a system and method for using an electro-pneumatic insufflator for magnetic resonance imaging, such as for virtual colonoscopy. Embodiments of the invention further provide a MRI imaging suite and a method for distension of a body part to be imaged. As an alternative to the complete redesign of an electro-magnetic insufflator, embodiments of the current invention utilize a standard electro-pneumatic insufflator that operates in a location impervious to electromagnetic radiation using an electromagnetically inactive connection tube.

APPARATUS AND METHOD FOR DETECTION, QUANTIFICATION AND CLASSIFICATION OF EPIDERMAL LESIONS

An apparatus for recording skin lesions on a patient comprises an apparatus for acquiring images and a control and processing unit connected to the apparatus so as to acquire and process a plurality of images of the patient positioned in different angular positions with respect to the apparatus. The control and processing unit comprises a processing block which receives at its input the plurality of images acquired by the apparatus and provides at its output a two-dimensional image obtained as a planar development of a three-dimensional image of the patient calculated in the processing block from the plurality of images acquired. By means of extraction of characteristics indicative of the lesions from the two-dimensional image it is possible to classify the lesions in an automatic or semi-automatic manner. A method for electronically recording skin lesions on a patient is also described.

Method for non-contrast enhanced magnetic resonance angiography

A method for non-contrast enhanced magnetic resonance angiography (MRA) that has a short scan time and is insensitive to patient motion is provided. More particularly, the method provides significant arterial conspicuity and substantial venous signal suppression. A two-dimensional single shot acquisition is employed and timed to occur a specific time period after the occurrence of an R-wave in a contemporaneously recorded electrocardiogram. In this manner, k-space data is acquired that is substantially insensitive to variations in arterial flow velocity, or heart rate, and that further substantially suppresses unwanted venous signal in a prescribed imaging slice.

Scanned laser vein contrast enhancer

The present invention is a Miniature Vein Enhancer that includes a Miniature Projection Head. The Miniature Projection Head may be operated in one of three modes, AFM, DBM, and RTM. The Miniature Projection Head of the present invention projects an image of the veins of a patient, which aids the practitioner in pinpointing a vein for an intravenous drip, blood test, and the like. The Miniature projection head may have a cavity for a power source or it may have a power source located in a body portion of the Miniature Vein Enhancer. The Miniature Vein Enhancer may be attached to one of several improved needle protectors, or the Miniature Vein Enhancer may be attached to a body similar to a flashlight for hand held use. The Miniature Vein Enhancer of the present invention may also be attached to a magnifying glass, a flat panel display, and the like.

SMART DEVICE AND SYSTEM FOR TREATMENT OF GASTRIC REFLUX

A smart device that monitors the condition of the lower esophagus by means of cameras, pH sensors, and other biometric sensors. The device may be equipped with movable arms that facilitate the collection of tissue biopsies from the esophagus as well as a reservoir that contains a medicament such as an antacid or other medicament useful for treating GERD. Data from the cameras and sensors may be transmitted and processed outside of the body and used to diagnose and treat esophageal disorders and can provide early detection of esophageal cancer or to treat GERD.

METHOD FOR RECOGNIZING A GESTURE AND AN ELECTRONIC DEVICE THEREOF

To recognize a gesture and control a function in an electronic device, an operating method of an electronic device includes the operations of detecting a change of a Radio Frequency (RF) signal emitted into a body using an RF sensor, determining a gesture corresponding to the RF signal based on reference data corresponding to the gesture, and executing a function of the electronic device corresponding to the determined gesture.

Systems, methods, and computer-readable media for gene and genetic variant prioritization

Systems, methods, and computer-readable media are disclosed for performing image processing in connection with phenotypic analysis. For example, at least one processor may be configured to receive electronic numerical information corresponding to pixels reflective of at least one external soft tissue image of an individual and access geographically dispersed genetic information stored in a database. The geographically dispersed genetic information may include numerical data that correlates anomalies in pixels in soft tissue images of a plurality of geographically dispersed individuals to specific genes or to specific genetic variants. The at least one processor may also be configured to compare the electronic numerical information for the individual with the numerical data of the geographically dispersed genetic information stored in a database, to determine at least a likelihood that the individual has a specific genetic variant, and prioritize, based on the comparison, one or more genetic ...

Biometric information input apparatus and biometric information input method

A biometric information input apparatus includes an image capturing section configured to obtain a captured image of a biological object; a pliable part detecting section configured to detect whether there is a pliable part on a surface of the biological object by obtaining a distance to the surface of the biological object from the captured image and comparing the obtained distance with a predetermined distance to be compared set beforehand; and an extracting section configured to extract biometric information from the captured image if the pliable part is not detected by the pliable part detecting section.

IMAGE PROCESSING AND PATIENT-SPECIFIC MODELING OF BLOOD FLOW

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

SUBJECT INFORMATION ACQUISITION APPARATUS

A subject information acquisition apparatus includes an electromechanical conversion element which receives an elastic wave generated by irradiating with an electromagnetic wave an object in a subject and converts the received elastic wave into an electric signal; a moving device moves the electromechanical conversion element; a signal processing device calculates an image value based on the electric signal. The moving device moves the electromechanical conversion element from a first position to a second position, the electromechanical conversion element receives the elastic wave at the first position and converts the received elastic wave into a first electric signal, and receives the elastic wave at the second position and converts the received elastic wave into a second electric signal; when the electromechanical conversion element is situated at the second position, the signal processing device calculates a first image value at a specified position inside the subject based on the first ...

SYSTEM AND METHOD FOR AUTOMATIC START TIME ADJUSTMENT IN MULTI-PHASE SCANNING

An MR apparatus creating a timeline suitable for data acquisition in several temporal phases. The MR apparatus including a method for creating a timeline TL2 having a scan time of TS1 based on a reference timeline TL0 having a scan time of TS. The method setting start points in time of scans SC1, SC3 and SC4 in the timeline TL2 to the same points in time as those in the reference timeline TL0, respectively. The method also setting the start point in time of the scan SC2 in the timeline TL2 to a sum of the scan time TS1 and a delay time TD1 with respect to the scan SC1 in the timeline TL2.

IMAGE PROCESSING APPARATUS, IMAGE PROCESSING METHOD, AND NON-TRANSITORY COMPUTER-READABLE STORAGE MEDIUM

An image processing apparatus acquires a plurality of pieces of first image data generated using volume data that is based on acoustic waves, extracts feature points from a plurality of pieces of the first image data, sets an unnecessary region to one or a plurality of pieces of the first image data using a distribution of the extracted feature points, reduces pixel values of the unnecessary region in one or a plurality of pieces of the first image data to which the unnecessary region has been set, and generates second image data using one or a plurality of pieces of the first image data in which the pixel values of the unnecessary region have been reduced and one or a plurality of pieces of the first image data in which the unnecessary region is not included.

TISSUE SIMILARITY MAPPING

A method is disclosed including: receiving a time resolved series of magnetic resonance (MR) images of an imaged region of a subject; processing the images to generate comparison data by comparing a temporal behavior of a reference region of the MR images to at least one other region of the MR images; an generating an output based on the comparison data. The method may be applied in a variety of contexts, including perfusion weighted imaging, determination of T2*, and other time series functions.

SYSTEMS AND METHODS FOR DETECTING INTRACRANIAL PRESSURE AND VOLUME

It has been discovered that even mild changes in cerebrospinal fluid (CSF) pressure or intracranial pressure (ICP) can be detected immediately as evidenced by distortions in the ONS surface structure. Further, the changes in the ONS persist after the CSF pressure has returned to normal. The stability of ONS distortions provides a means of detecting transient changes in brain pressure even when the use of the diagnostic ultrasound is delayed. One embodiment provides systems and methods for detecting or diagnosing brain injury by detecting distortions or deformations of the ONS, preferably using ultrasound.

COMPOSITIONS AND METHODS FOR MONITORING THE TREATMENT OF BREAST DISORDERS

Disclosed herein are systems, media, and methods for processing and aligning breast images and uses thereof. The processes disclosed herein may be used to diagnose, predict, and monitor the status or outcome of breast density masking, and breast cancer in a subject, and methods of treating the same.

METHODS AND SYSTEMS FOR CONTINUOUS MEASUREMENT OF ANOMALIES FOR DYSMORPHOLOGY ANALYSIS

Computer-assisted methods for assisting in anomaly identification relating to a dysmorphology analysis comprise retrieving and/or generating a sequence of progressively changing images that depict morphing of at least a subject's first physical feature, between at least a first state representing an identification of a first anomaly relating to a dysmorphology and a second state representing lack of the identification of the first anomaly. The number of images in the sequence is selected to provide a substantially continuous transition between the first and second states. The retrieved and/or generated images are displayed on a display of a processing device, and a user interface on the processing device is provided for a user to make an image selection, which can then be used to determine identification or lack of identification of the anomaly.

СИСТЕМА НАВИГАЦИИ ДЛЯ МЕДИЦИНСКИХ ИЗОБРАЖЕНИЙ

Изобретение относится к навигации для медицинских изображений. Технический результат заключается в обеспечении возможности навигации в интерактивном режиме по набору изображений срезов. Такой результат достигается тем, что обеспечивают возможность переключения из статического режима просмотра в режим навигации на основе команд навигации, принимаемых из пользовательского устройства ввода, которое выполнено с возможностью его управления пользователем, дисплейный процессор выполнен с возможностью формирования в статическом режиме просмотра выходного изображения, содержащего одно изображение среза из набора изображений срезов и дополнительно выполнен с возможностью замены в режиме навигации упомянутого одного изображения среза в выходном изображении посредством объемного рендеринга блока объема изображений, причем блок содержит более одного изображения среза. 5 н. и 8 з.п. ф-лы, 24 ил.

СПОСОБЫ ОЦЕНКИ СООТВЕТСТВИЯ НОРМЕ БИОЛОГИЧЕСКОЙ ТКАНИ

Группа изобретений относится к медицинской технике, а именно к средствам электромагнитного биозондирования и биовизуализации. Портативная система содержит портативный блок управления, подключенный к блоку управления ручной зонд, распространяющий генерируемое блоком управления электромагнитное поле, при этом зонд можно перемещать вокруг биологического объекта и помещать внутрь объекта, во время работы зонд измеряет создаваемое электромагнитное поле, рассеянное и/или отраженное биологическим объектом, и блок слежения, который фиксирует положение ручного зонда, причем блок слежения является внутренним устройством в портативном блоке управления. Способ оценки функционального и/или патологического состояния биологической ткани содержит генерацию электромагнитного сигнала, при этом данный электромагнитный сигнал является первым сигналом, передачу по меньшей мере части первого сигнала от портативного блока управления на ручной зонд с проводным подключением, излучение посредством ручного зонда ...

Способ и устройство для выбора области диагностики и система диагностики для определения эластичности

Группа изобретений относится к медицине и представлена способом, устройством выбора области диагностики и системой определения эластичности. Способ включает разделение визуализирующей информации о тканях органа, которую необходимо определить во множестве подобластей диагностики, и расчет характеристического параметра информации о тканях органа в пределах подобласти диагностики. А также определение граничной области тканей органа в соответствии с визуализирующей информацией о тканях органа, которые необходимо идентифицировать, и определение области диагностики тканей органа в соответствии с граничной областью тканей органа и заранее заданным условием для характеристического параметра. Устройство содержит: блок разделения области, блок расчета характеристического параметра, блок распознавания граничной области и блок определения области диагностики. Система содержит: устройство получения информации, устройство визуализации изображения, устройство настройки датчика и отображающее устройство ...

СВЯЗЫВАНИЕ ОТЧЕТА / ИЗОБРАЖЕНИЯ

СПОСОБ И СИСТЕМА ДЛЯ БЫСТРОЙ РЕКОНСТРУКЦИИ ИЗОБРАЖЕНИЯ МРТ ИЗ НЕДОСЕМПЛИРОВАННЫХ ДАННЫХ

Изобретение относится к обработке медицинских изображений. Техническим результатом является сокращение времени реконструкции изображения МРТ из недосемплированных данных. Способ включает в себя: получение недосемплированного спектра в k-пространстве, инициализацию несемплированных позиций в k-пространстве начальным приближением, многополосное разложение первоначально реконструированного спектра на ряд отдельных спектров, выполнение реконструкции с использованием словаря изображений, соответствующих разложенным полосам, и объединение реконструированных изображений для получения результирующего целевого изображения, причем инициализацию реализуют посредством регуляризации l-нормы, и реконструкцию с использованием словаря вычисляют посредством чередования разреженной аппроксимации и восстановления измеренных частот. 2 н. и 16 з.п. ф-лы, 5 ил.

ПРИБОР И СПОСОБ ДИАГНОСТИКИ РАКОВОГО ЗАБОЛЕВАНИЯ

System zum patientenspezifischen Modellieren von Blutfluss

System zum Ermöglichen der Bewertung einer Koronararterie eines Patienten basierend auf einem berechneten fraktionellen Flussreservewert, wobei das System Folgendes umfasst: wenigstens ein Computersystem, das konfiguriert ist, um: auf einem digitalen Anzeigegerät ein dreidimensionales Modell wenigstens eines Teils mehrerer Koronararterien, die von einer Aorta des Patienten abzweigen, anzuzeigen; auf dem Anzeigegerät eine erste fraktionelle Flussreserve anzuzeigen, die vom Computersystem für wenigstens eine der Koronararterien in dem dreidimensionalen Modell berechnet wurde; eine Eingabe hinsichtlich eines Behandlungsplans für die wenigstens eine der Koronararterien zu empfangen, wobei der Behandlungsplan ein Erweitern eines durch die wenigstens eine der Koronararterien definierten Lumens beinhaltet; und eine zweite fraktionelle Flussreserve für die wenigstens eine der Koronararterien zu berechnen und auf dem Anzeigegerät anzuzeigen, wobei das Berechnen der zweiten fraktionellen Flussreserve ...

Anschließen von Spulen an ein MR-Gerät

MR-Gerät (2, 20), aufweisend- eine Patientenliege (2) mit mindestens einem ersten Geräteanschluss (12) zum Anschließen einer anterior positionierten MR-Spule (4) und- mit mindestens einem zweiten Geräteanschluss (14) zum Anschließen einer posterior positionierten MR-Spule (5), und aufweisend- einen Speicher, in dem mindestens ein Satz von Coilfile-Parametern für die anterior positionierte MR-Spule (4) und ein Satz von Coilfile-Parametern für die posterior positionierte MR-Spule (5) gespeichert sind, wobei- die beiden Geräteanschlüsse (12, 14) unterschiedlich ausgebildet sind, wobei- das MR-Gerät (2) dazu eingerichtet ist, über den ersten Geräteanschluss (12) eine Kennung der anterior positionierten MR-Spule (4) auszulesen und über den zweiten Geräteanschluss (14) eine Kennung der posterior positionierten MR-Spule (5) auszulesen, wobei- das MR-Gerät (2, 20) dazu eingerichtet ist, von der anterior positionierten MR-Spule (4) stammende MR-Signale mittels eines Satzes von Coilfile-Parametern ...

Radiomic signature of adipose

A method of calculating a radiomic signature for characterising a region of interest comprising adipose tissue. Values of a plurality of radiomic features in the region of interest are calculated from medical imaging data, and the values of the plurality of radiomic features are then used to calculate the radiomic signature. The signature may be indicative of adipose tissue dysfunction of an individual. A dataset of radiomic features may be created from medical imaging data from a first group of individuals or patients identified as having adipose tissue dysfunction, and a second group of individuals or patients identified as not having adipose tissue dysfunction. The radiomic signature may be calculated from the radiomic features of the second group of individuals. The radiomic signature may provide a measure of texture in the region of interest of adipose tissue. The radiomic signature may be calculated using machine learning algorithms. The medical imaging data may be Computed Tomography ...

Systems and methods for segmentation and measurement of a skin abnormality

Determination of spectral filters for spectral imaging

Radiomic signature of adipose

Methods and systems for multi view pose estimation using digital computational tomography

The present invention discloses several methods related to intra-body navigation of a radiopaque instrument through natural body cavities. One of the methods discloses the pose estimation of the imaging device using multiple images of radiopaque instrument acquired in the different poses of imaging device and previously acquired imaging. The other method resolves the radiopaque instrument localization ambiguity using several approaches, such as radiopaque markers and instrument trajectory tracking.

Method and system for patient-specific modeling of blood flow

C:\Users\kIl\AppData\Locl\Temp12713_1 DAOBAFC.DOCX-22 12 2015 Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Methods of treating and preventing vascular instability diseases

Methods are disclosed for treating and preventing vascular instability diseases, such as cerebral cavernous malformation, by the administration of tempol, cholecalciferol, derivatives thereof, pharmaceutically-acceptable salts thereof, or combinations thereof. Methods are disclosed for reducing the number of cerebral cavernous malformation (CCM) lesions in a patient having, or at risk of developing, at least one CCM lesion. Methods are disclosed for reducing the growth rate of the number of cerebral cavernous malformation (CCM) lesions in a patient having, or at risk of developing, at least one CCM lesion. Method are disclosed for preventing or treating a sign or symptom of cerebral cavernous malformation (CCM) in a patient with at least one CCM lesion. Methods are disclosed for decreasing cerebrovascular inflammation, reducing cerebrovascular permeability, or both, in a patient having, or at risk of developing, a cerebral cavernous malformation (CCM) lesion. Methods are disclosed for improving ...

Systems and methods for visualizing ablated tissue

Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter (1601) having a distal end and a proximal end; an inflatable balloon (1603) disposed about the distal end of the catheter (1601); and an optical housing (1803) extending from the distal end of the catheter (1601) into the balloon (1603), the optical housing (1803) being configured to position inside the balloon (1603) a light source (1805) for illuminating a tissue outside the balloon (1603) and a camera (1804) for imaging the illuminated tissue.

Method and system for patient-specific modeling of blood flow

C:\Users\kll\AppData\Local\Temp12713 IDAOBAFC.DOCX-22 12/2015 Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Systems And Methods For Visualizing Ablated Tissue

Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue comprising: a catheter (1601) having a distal end and a proximal end; an inflatable balloon (1603) disposed about the distal end of the catheter (1601); and an optical housing (1803) extending from the distal end of the catheter (1601) into the balloon (1603), the optical housing (1803) being configured to position inside the balloon (1603) a light source (1805) for illuminating a tissue outside the balloon (1603) and a camera (1804) for imaging the illuminated tissue. Figure 16 ...

Inexpensive Nail-fold Capillaroscopy for Early Detection of Cardio-Metabolic Disease

Our Invention "Inexpensive Nail-fold Capillaroscopy for Early Detection of Cardio-Metabolic Disease" is a Diabetes has become one of the major healthcare challenge in India. According to International Diabetes Federation (IDF), there are 77 million diabetic people in India. This makes the prevalence of disease as high as 8.9%. Moreover, this number is only for reported case. The early detection of the disease is key as the comorbidities increases with the progression of the disease. Some of the complications associated with diabetes as retinopathy, neuropathy, nephropathy, cardiovascular disease, and diabetic foot. This make it imperative to design an inexpensive non-invasive method for early detection of the cardio-metabolic disease. The approach used for early detection of diabetes like Diabetic Retinal Screening (DRS) are prohibitive in cost. The tool proposed in this study uses Nail-fold Capillaroscopy for early detection of the vascular complications. The tool proposed in this proposal ...

OPHTHALMIC LENS WITH RETINAL VASCULARIZATION MONITORING SYSTEM

The present invention relates to an ophthalmic device with a retinal vascularization monitoring system and associated methods. In some embodiments, the ophthalmic device can be a contact lens with a retinal vascularization monitoring system that can be used to monitor temporal changes of a pulsating vessel forming part of the retinal vascularization. Further, the retinal vascularization monitoring system may include elements for delivering a signal, including an audible and/or visual message, to the user that can be useful for identifying abnormal conditions such as a cardiac failure without delay. The audible and/or visual messages can be signals communicated to the user using one or both of the ophthalmic device and a wireless device in communication with the ophthalmic device. Fig._1B 1of8 ...

DIAGNOSTIC SUPPORT PROGRAM

Provided is a diagnostic support program that can display the movement of an area that changes shape with each respiration element that includes all or part of an inhale or an exhale. The program includes: processing in which a plurality of frame images are acquired from a database that stores images; processing in which the period of a respiration element that includes all or part of an inhale or an exhale is specified on the basis of the pixels in a specific area of the frame images; processing in which a lung field is detected on the basis of the specified period of the respiration element; processing in which the detected lung field is partitioned into a plurality of block areas, and the change in the block areas of the frame images are calculated; processing in which a Fourier transform is performed on the change in the block areas of the frame images; processing in which, of the spectra obtained after the Fourier transform, the spectra that are within a fixed band that includes the ...

METHOD AND SYSTEM FOR PATIENT-SPECIFIC MODELING OF BLOOD FLOW

ANALYTIC MORPHOMICS: HIGH SPEED MEDICAL IMAGE AUTOMATED ANALYSIS METHOD

A computer-implemented method is provided for anatomically indexing a subject. The method includes: receiving image scan data representing a volume of a subject, where the image scan data is comprised of a plurality of image slices of the subject and includes at least a portion of a vertebral column of the subject; identifying the vertebral canal of the vertebral column of the subject in the image scan data; determining a plurality of markers for the vertebral column, where each marker is indicative of a different vertebral body of the vertebral column and includes its location in the image scan data defined in a coordinate system, such that the plurality of markers define a vertebral level coordinate system; and storing each marker along with its location in a database. The markers can subsequently be used to reference other anatomical components of the subject across different image scans.

SKIN DIAGNOSTIC AND IMAGE PROCESSING SYSTEMS, APPARATUS AND ARTICLES

Skin diagnostic techniques employed in conjunction with image processing techniques. For example, a user information module captures a user skin image. A graphical user interface enables selection of a skin-related application from a plurality of skin-related applications. A processor determines user skin image data from the user skin image, and identifies one or more sets of skin image data in the skin image database that correspond to the user skin image data based on one or more parameters specified by the skin-related application. The processor applies at least one image processing filter that corresponds to the one or more identified sets of skin image data from the skin image database to the user skin image to generate a simulated user skin image. An output display displays the simulated user skin image.

SYSTEMS AND METHODS FOR PORTABLE MAGNETIC RESONANCE MEASUREMENTS OF LUNG PROPERTIES

A portable magnetic resonance (MR) system for quantitatively measuring properties of a subject's lungs, such as regional ventilation and lung density, is provided. The portable MR system includes a magnet, radio frequency (RF) coil assembly, and spectrometer system. The magnet can be positioned near the subject's chest. The magnetic field of the magnet substantially homogeneous in a region-of-interest located at a distance from the surface of the magnet that localizes the region-of-interest in the subject's lung. The RF coil assembly includes one or more RF coils that are sized to be positioned near the subject's chest, and receives MR signals from the region-of-interest. The spectrometer system controls the RF coil assembly and computes from the acquired MR signals, a quantitative metric indicative of a characteristic of the subject's lung in the region-of-interest. An active noise cancellation system is provided so RF shielding of the portable MR system is not required.

Method and system for patient-specific modeling of blood flow

METHOD AND APPARUTUS FOR GENERATEING EXCITATION PULSE, EXCITING SPINS WITHIN VESSEL, AND ANGIOGRAPHY

The invention relates to a method for generating an HF excitation pulse together with a gradient curve to excite an arbitrarily shaped volume with a magnetic resonance system. The method includes the steps that a volume segment is prepared in which the volume is situated, such that only spins within the volume yield an MR signal portion in the subsequent detection of an MR signal. An MR signal is collected from the volume segment along a trajectory of k-space. At least one gradient for scanning k-space along the trajectory is switched during the collection. The HF excitation pulse is generated corresponding to the MR signal collected in a temporally inverted manner, and the gradient curve is generated corresponding to the temporally inverted curve of the at least one gradient to scan k-space.

Tissue similarity mapping

A method is disclosed including: receiving a time resolved series of magnetic resonance (MR) images of an imaged region of a subject; processing the images to generate comparison data by comparing a temporal behavior of a reference region of the MR images to at least one other region of the MR images; an generating an output based on the comparison data. The method may be applied in a variety of contexts, including perfusion weighted imaging, determination of T2*, and other time series functions.

METHOD OF CHARACTERIZING THE HUMAN CUTANEOUS RAISED

La présente invention concerne un procédé de caractérisation du relief cutané humain, notamment des signes liés au vieillissement cutané, comportant l'étape consistant à traiter une acquisition de données représentatives du relief cutané d'un individu à un instant donné, de façon à : - identifier au moins un objet caractéristique de ce relief, - mémoriser au moins une information permettant de reconnaître individuellement le ou les objets ainsi identifiés lors du traitement d'une nouvelle acquisition effectuée à un instant ultérieur, et - permettre de quantifier une évolution d'au moins un descripteur de ce ou ces objets, par comparaison des données entre les acquisitions.

환자별 혈류 모델링 방법 및 시스템

... 본 발명의 환자의 심혈관 정보를 결정하기 위한 시스템에 관한 것으로, 상기 시스템은 적어도 하나의 컴퓨터 시스템을 포함하며, 상기 적어도 하나의 컴퓨터 시스템은, 환자 심장의 기하 형태에 관한 환자별 데이터를 수신하도록 구성되고, 환자별 데이터에 기초하여 환자 심장의 적어도 일부분을 나타내는 3차원 모델을 생성하도록 구성되며, 환자 심장의 혈류 특성에 관한 물리학-기반 모델을 생성하도록 구성되고, 상기 3차원 모델 및 물리학-기반 모델에 기초하여 상기 환자 심장 내의 분획 혈류 예비력(FFR: Fractional Flow Reserve)을 결정하도록 구성된다.

METHODS AND COMPOUNDS FOR THE DIAGNOSIS AND TREATMENT OF

심부전을 평가하기 위한 장치 및 방법

... 다양한 실시 예에 따르면, 심부전을 평가하기 위한 장치는 사용자의 이미지 데이터를 캡쳐하도록 구성된 이미지 센서와, 사용자에 대한 센서 데이터를 캡쳐하도록 구성된 센서와, 이미지 데이터 및 센서 데이터를 저장하도록 구성된 메모리와, 상기 이미지 센서, 상기 센서 및 상기 메모리에 결합된 프로세서를 포함한다. 상기 프로세서는 센서 데이터에 기반하여 사용자에 관한 생물학적 상태를 검출하고, 생물학적 상태를 검출함에 대응하여 사용자의 이미지 데이터를 획득하고, 이미지 데이터로부터 사용자의 심장 건강에 대한 시각적 특성을 검출하고, 시각적 특정을 검출함에 대응하여, 사용자에 대한 심부전 정보를 제공하도록 구성된다.

IMAGING AND DIAGNOSTIC METHODS, SYSTEMS, AND COMPUTER-READABLE MEDIA

One aspect of the present subject matter provides an imaging method including: receiving a trigger signal; after a period substantially equal to a trigger delay minus an inversion delay, applying a non-selective inversion radiofrequency pulse to a region of interest followed by a slice- selective reinversion radiofrequency pulse to a slice of the region of interest of a subject; and after lapse of the trigger delay commenced at the cardiac cycle signal, acquiring a plurality of time-resolved images of the slice of the region of interest from an imaging device.

System and method for intraoperative video processing

A monitoring method and system for providing visual enhancements during a medical procedure is described. The method includes capturing current visual information of a site during the medical procedure in real time, storing at least a portion of the captured visual information as stored visual information, identifying a feature of interest in at least one of the current visual information and the stored visual information; generating feedback data associated with the feature of interest, and displaying a virtual representation of the feedback data overlaid on the current visual information.

Visual-Assisted Insertion Device

A visual-assisted insertion device for ensuring accurate and repeatable needle insertion into the human body regardless of skill or training. A user of the visual-assisted insertion device may accurately perform inter-organ needle insertion by determining a desired needle-insertion point on an ultrasound display screen, wherein the insertion point and angle of the needle is automatically calculated and mechanically adjusted to correspond to the desired needle-insertion point. Accordingly, unsuccessful inter-organ needle insertion is minimized through a handheld, visual-assisted insertion device which simplifies the inter-organ needle insertion process.

Quantitative prostate cancer imaging with magnetic resonance fingerprinting (MRF)

Example embodiments associated with characterizing a sample using NMR fingerprinting are described. One example NMR apparatus includes an NMR logic that repetitively and variably samples a (k, t, E) space associated with an object to acquire a set of NMR signals that are associated with different points in the (k, t, E) space. Sampling is performed with t and/or E varying in a non-constant way. The NMR apparatus may also include a signal logic that produces an NMR signal evolution from the NMR signals and a characterization logic that characterizes a tissue in the object as a result of comparing acquired signals to reference signals. Example embodiments facilitate distinguishing prostate cancer tissue from normal peripheral zone tissue based on quantitative data acquired using NMR fingerprinting in combination with apparent diffusion co-efficient (ADC) values or perfusion values acquired using DWI-MRI or DCE-MRI.

Apparatus and method for processing physiological signal

A physiological signal processing apparatus and a method for the same. The physiological signal processing apparatus includes a first light-emitting element, a second light-emitting element, a light control module, an image sensing module and an analyzing module. The light control module is capable of controlling the first light-emitting element to emit a first light beam and the second light-emitting element to emit a second light beam on a light guide panel for a finger to touch. The image sensing module is capable of sensing the first light beam and the second light beam reflected by the light guide panel and acquiring an image signal of the finger. The analyzing module is capable of analyzing the image signal extracted by the first light beam to acquire a first physiological signal and analyzing the image signal extracted by the second light beam to acquire a second physiological signal.

Method for imaging a site of arthritis in an animal

The present disclosure demonstrates that a nanovesicle comprising a membrane-associated lysosomal protein (saposin C; “SapC”) incorporated into a phospholipid has a high fusogenic affinity for phosphatidylserine-rich domains on the surfaces of target cell membranes. It is believed that the nanovesicles target surface exposed phosphatidylserine on the membranes of cells associated with arthritis, allowing for detection of local tissue damage associated with arthritis. In plasma membranes, phosphatidylserine is normally present only on the inner leaflet but is “flipped” to the outer leaflet upon the presence of cell damage. Incorporation of the fluorophore in the nanovesicles allows for the in vivo visualization of the fluorophore in targeted tissue and provides a technique to detect and evaluate the onset and progression of arthritic disease in an animal. Furthermore, the use of the nanovesicle in optical imaging methods provides great promise for analyzing events occurring early in the ...

Diagnosis using a digital oral device

A system and method for instant tongue sampling and diagnosis includes acquiring a plurality of tongue images from a plurality of digital oral devices, and a current health conditions, building a diagnosis framework for diagnosing a current health condition of a user by: i) analyzing the collected tongue images with a visual recognition engine to determine tongue characteristics of each tongue captured in the tongue images, and ii) correlating the tongue characteristics with the current health condition, identifying tongue characteristics from a received image of the tongue using the visual image recognition engine, applying the diagnosis framework to the tongue characteristics of the tongue to diagnosis the current health condition of the user, and modifying a graphical user interface of the digital oral device to display a custom health report indicative of the current health condition of the user, in response to applying the diagnosis framework.

IMPLANT PLACEMENT METHOD WITH FEEDBACK

Methods for performing orthopaedic surgical procedures including generating scan data from the intra-operatives scans and comparing the scan data to a surgical plan are disclosed. The scan data and other feedback data are used to validate the position and orientation of orthopaedic prosthetic component implanted in a body of the patient.

MRI IMAGE FUSION METHODS AND USES THEREOF

A method for fusing a pre-operative MRI prostate image to an intra-operative TRUS or CT prostate image according to a least-cost affine transformation of the MRI contour onto the TRUS or CT contour, with smooth non-linear warping adjustment. MRI and CT processing may be performed as a pre-operational procedure for increased efficiency, while TRUS may be performed concurrent with a surgical procedure.

Registration device, checking device, program, and data structure

There is proposed a registration apparatus, a verification apparatus, and a program capable of improving authentication accuracy and an identification data structure capable of improving reliability. A blood vessel line included in an image is divided into a plurality of partial lines on the basis of end points and a diverging point of the blood vessel line. Coefficients of terms corresponding to degrees included in a polynomial equation for an n-th order curve representing each of the partial lines are extracted. Data including points at both ends of each of the partial lines and the coefficients is generated.

Eye tracking system with biometric identification

A method for measuring eye tracking in a patient and capturing ocular biometric identifying information from the patient may involve: displaying a video to the patient on a stimulus screen of an eye tracking and biometric identification system; tracking movement of the patient's eyes during display of the video via an eye tracking camera of the eye tracking and biometric identification system; capturing ocular biometric identifying information from the patient with an ocular biometric capture device of the eye tracking and biometric identification system; generating, with a computer processor of the eye tracking and biometric identification system, a score representing an ability of the patient's eyes to track the video; and confirming, with the computer processor, an identity of the patient, based on the captured ocular biometric identifying information.

DENTAL IMPLANT METHOD AND APPARATUS

A method of manufacturing a dental implant wherein the resulting dental implant closely corresponds to or matches the size and shape of the extracted tooth. Generally stated, the method comprises the steps of (i) three dimensionally mapping the size and shape of the crown and root of a tooth to be extracted and (ii) using said mapping to manufacture a dental implant to correspond to the size and the shape of said crown and root of the tooth to be extracted. Further, the resulting dental implant may comprise a number of anti-migratory structural features that function to better secure the dental implant to the patient.

Device with Optical Heart Rate Sensor and Corresponding Methods

An electronic device includes an image capture device that can be an always on image capture device. The electronic device includes one or more processors operable with the image capture device and a wireless communication circuit operable with the one or more processors. The one or more processors determine, from images of a face and torso of a user of the electronic device captured by the image capture device, that a heartrate of the user of the electronic device increases by a predetermined threshold above a resting level heartrate of the user of the electronic device. In response, the one or more processors cause the wireless communication circuit to transmit a climate adjustment request to a climate control device.

Camera having transdermal optical imaging function

A camera having blood optical imaging function, comprising: a lens, an image sensor, a main control module, a blood optical imaging algorithm module and an IP network interface module; the lens is located at the image acquiring position of the camera; the output end of the image sensor are in electric connection with input ends of the main control module and the blood optical imaging algorithm module, respectively; the main control module is in electric connection with the blood optical imaging algorithm module and the IP network interface module, respectively. The blood optical imaging algorithm is directly applied to the camera, so that the algorithm module can directly acquire original RGB data from the sensor, improving the accuracy of detection and the quality of blood vessel imaging, and achieving remote detection of the blood optical images of a face, while detecting the blood optical images of a moving face.

METHODS AND SYSTEMS FOR IMAGE SYNCHRONIZATION

One or more devices, systems, methods, and storage mediums for performing image synchronization using one or more imaging modalities are provided herein. Examples of applications include imaging, evaluating and diagnosing biological objects, such as, but not limited to, for Gastro-intestinal, cardio and/or ophthalmic applications, and being obtained via one or more optical instruments, such as, but not limited to, optical probes, catheters, capsules and needles (e.g., a biopsy needle). Devices, systems, methods, and storage mediums may include or involve a method, such as, but not limited to, for performing image synchronization.

СВЯЗЫВАНИЕ ОТЧЕТА / ИЗОБРАЖЕНИЯ

Изобретение относится к связыванию медицинского отчета и изображения, ссылку на которое он содержит. Технический результат заключается в уменьшении затрат времени на составление отчетов в работе отделения лучевой диагностики. Такой результат достигается за счет того, что способ включает визуальное отображение медицинского отчета в электронном виде, который содержит ссылку на набор изображений в электронном виде, извлечение ссылок на набор изображений в электронном виде из медицинского отчета в электронном виде; связывание медицинского отчета в электронном виде с набором изображений в электронном виде путем определения ткани на каждом изображении из набора изображений в электронном виде, на которых было выполнено измерение; извлечения описания, связанного с изображениями, на которых было выполнено измерение; и выявления изображений в электронном виде, на которых имеется измеренное значение; и визуальное отображение выявленных изображений со ссылками и описанием. 3 н. и 12 з.п. ф-лы, 9 ил ...

Способ измерения ликворо-краниального индекса на основе математической модели

Изобретение относится к медицине, а именно к реаниматологии и интенсивной терапии, и может быть использовано при лечении панкреонекроза. Способ включает проведение компьютерной и/или магнитно-резонансной томографии для определения ширины боковых желудочков и 3 желудочка. Величина ЛКИ определяется по математической модели расчета в зависимости от величины N по формуле ЛКИ=0,50102*N, где ЛКИ - ликворо-краниальный индекс, N – показатель, равный сумме ширины боковых желудочков и третьего желудочка, мм. Способ обеспечивает получение максимально приближенного к анатомическим особенностям расчета ЛКИ за счет проводимых измерений. 2 ил., 2 табл., 1 пр.

Способ и устройство для выбора области диагностики и система диагностики для определения эластичности

Имплантат, имеющий форму, адаптированную для прикрепления его к структуре костной ткани, содержащий основание, и связанный с ним способ его изготовления

Группа изобретений относится к медицине. Имплантат для прикрепления к кости с опорной конструкцией, создаваемый на основе данных конкретного пациента содержит по меньшей мере один крепежный участок. Крепежный участок покрывает внешнюю структуру костной ткани и предназначен для прикрепления к кости. Основания для приема протеза непосредственно или с помощью промежуточной части выступают из опорной конструкции. Основания являются целостными едиными компонентами опорной конструкции. Имплантат имеет участки, фиксирующие форму кости, которые окружают кость, и они выполнены в геометрической конфигурации и геометрически выровнены таким образом, что на кости создается местоположение для фиксации формы, и таким образом, что местоположение создает устойчивое опорное положение имплантата на кости. Способ изготовления имплантата содержит этап захвата данных конкретного пациента посредством МРТ и/или КТ, создающий опорную конструкцию и/или основание на основе данных конкретного пациента посредством ...

СПОСОБЫ ЛЕЧЕНИЯ И ПРОФИЛАКТИКИ РАЗВИТИЯ ЦЕРЕБРОВАСКУЛЯРНЫХ ЗАБОЛЕВАНИЙ

Systems and methods for anatomy-based registration of medical images acquired with different imaging modalities

Systems, Methods and Computer-Accessible Medium Which Provide Microscopic Images of at Least One Anatomical Structure at a Particular Resolution

Exemplary embodiments of apparatus, systems and methods can be provided for providing at least one electro-magnetic radiation to at least one sample. For example, a plurality of wave-guiding arrangements can be provided which are configured to (i) provide the electro-magnetic radiation(s), and (ii) at a point of emission of each of the wave guiding arrangements, cause a phase of each of the electro-magnetic radiation(s) to have a predetermined value. The exemplary apparatus can be part of a probe. Further the exemplary apparatus can include an interferometric arrangement provided in communication with the probe and/or be part of the probe.

Photobiological measuring device and analyzing method

A photobiological measuring device has a computing unit generating an unwanted component removal observation signal by removing the signal corresponding to the unwanted component from an observation signal. The computing unit is provided with: a mixing matrix making unit for separating observation signals into the products of a mixing matrix and independent component signals through independent component analysis; a power spectrum computing unit generating transformed independent component signals, which are functions of frequency and intensity, by Fourier transforming the independent component signals, which are functions of time and intensity, and computing power spectra in predetermined frequency bands of transformed independent component signals; and an unwanted component signal determining unit detecting the independent component signal corresponding to the unwanted component from among the independent component signals by comparing the power spectrum in a predetermined frequency band of each transformed independent component signal with a threshold.

Brain information output apparatus, robot, and brain information output method

A brain information output apparatus includes an intention determination information storage unit in which two or more pieces of intention determination information can be stored, with each intention determination information including a pair of an intention identifier, and a learning feature amount group including one or more feature amounts extracted from second learning data that is obtained by converting first learning data into intracerebral brain activity data, the first leaning data being acquired from the outside of the cranium of a user when the user performs a trial according to one intention; a first brain activity data acquiring unit that acquires first brain activity data from the outside of the cranium of a user; a second brain activity data acquiring unit that converts the first brain activity data to intracerebral brain activity data, and acquires second brain activity data; a feature amount group acquiring unit that acquires, from the second brain activity data, an input feature amount group including one or more feature amounts; an intention identifier acquiring unit that acquires an intention identifier corresponding to the input feature amount group based on the two or more pieces of intention determination information; and an intention identifier output unit that outputs the intention identifier.

Method and System For Patient-Specific Modeling of Blood Flow

Embodiments include a system for planning treatment for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of an anatomical structure of the patient, create a three-dimensional model representing at least a portion of the anatomical structure of the patient based on the patient-specific data, and determine a first fractional flow reserve within the anatomical structure of the patient based on the three-dimensional model and information regarding a physiological condition of the patient. The at least one computer system may be further configured to receive input from a user regarding a plan of treatment, modify the physiological condition of the patient based on the received input, and determine a second fractional flow reserve within the anatomical structure of the patient based on the modified physiological condition of the patient.

Arrangement and method for influencing and/or detecting magnetic particles

The present invention relates to an arrangement and a method for influencing and/or detecting magnetic particles in a region of action, in particular for monitoring of intra-cerebral or intra-cranial bleeding using Magnetic Particle Imaging (MPI). A common coupling unit per coil of a coil array is provided for coupling all signals for generating the magnetic fields to the set of common coils. Further, the same coils are used for acquiring detection signals. In this way a small scanner can be built that can be left permanently or can be provided periodically to the patient, in particular for bleeding monitoring.

Workstations with circuits for generating images of global injury

Physician interactive workstations with global voxel distribution visualization may also include one or more of a 3-D color scale image of a population of voxel in target regions, organs or systems. The workstation may be configured to evaluate intensity or other measures of voxels of patient images associated with tissue for early detection of a global injury.

Camera for detecting driver's state

The present invention provides a camera for detecting a driver's drowsiness state, which can increase the number of pixels in an image of a driver's eye even when using an image sensor having the same number of pixels as a conventional camera instead of a high definition camera. The camera of the present invention is, thus, capable of determining whether the driver's eyes are open or closed. The camera for detecting the driver's state according to the present invention includes a cylindrical lens mounted in front of the camera configured so as to enlarge an image in the vertical direction, a convex lens located in the rear of the cylindrical lens, an image sensor for taking an image of a driver's face formed by the cylindrical lens and the convex lens, and an image processor for extracting an eye area from the image of the driver's face and determining whether the driver's eyes are open or closed.

Magnetic resonance imaging apparatus and magnetic resonance imaging method

According to one embodiment, a MRI apparatus includes an acquisition unit, a reference section information calculating unit, a positioning unit and an imaging unit. The acquisition unit acquires frames of section image data including a heart from an object with use of magnetic resonance. The reference section information calculating unit calculates spatial positional information of a reference section of the heart based on the frames of the section image data. The positioning unit displays a reference section image of the heart on a display unit and performs positioning of an imaging part for imaging through the displayed reference section image of the heart. The reference section image is calculated from the frames of the section image data based on the positional information of the reference section. The imaging unit images the imaging part set by the positioning.

Optogenetic magnetic resonance imaging

Disclosed herein are systems and methods involving the use of magnetic resonance imaging and optogenetic neural stimulation. Aspects of the disclosure include modifying a target neural cell population in a first region of a brain to express light-responsive molecules. Using a light pulse, the light-responsive molecules in the target neural cell population are stimulated. Multiple regions of the brain are scanned via magnetic resonance imaging. The scans allow for observation of a neural reaction in response to the stimulation in at least one of the multiple regions of the brain.

Reagents and methods for modulating cone photoreceptor activity

The present invention provides reagents and methods for modulating cone photoreceptor activity, and devices for assessment of cone photoreceptor activity.

Image forming method and optical coherence tomograph apparatus using optical coherence tomography

An image forming method uses an optical coherence tomography as to an optical axis direction of plural pieces of image information of an object. First image information of an object is obtained at a first focus with respect to an optical axis direction to then object. A focusing position is changed by dynamic focusing from the first focus to a second focus along the optical axis. The second image information of the object is obtained at the second focus. A third image information, tomography image information of the object and including a tomography image of the first focus or the second focus, is obtained by Fourier domain optical coherence tomography. A tomography image or a three-dimensional image of the object is formed in positional relation, in the optical axis direction, between the first image information and the second image information using the third image information.

Automatic quantitative vessel analysis

Apparatus and methods are described for use with an image of blood vessels of a subject. In response to a user designating a single point on the image (a) a target portion of a blood vessel is automatically identified in the vicinity of the designated point, and (b) quantitative vessel analysis is performed on the target portion of the blood vessel. An output is generated based upon the quantitative vessel analysis. Other embodiments are also described.

Oral optical diagnosing apparatus and operating method thereof

An oral optical diagnosing apparatus and operating method are disclosed. The oral optical diagnosing apparatus includes a positioning module, an optical sensing module, a processing module, and a display module. After the positioning module selects a region to be diagnosed in a mouth, the optical sensing module will perform optical sensing on the region to be diagnosed to obtain optical information related to the region to be diagnosed. The processing module is used to analyze the optical information to generate an optical diagnosed result. The display module is used to display the optical diagnosed result.

Optical measurement system, portable optical measurement device used therein, and rehabilitation planning method using same

An optical measurement system having a main and a portable optical measurement devices. The portable optical measurement device is provided with a second case portable by the subject, C second light sending means for illuminating the subject, D second light receiving means receiving light emitted from the subject, a second holder worn on the head of the subject and having at least (C+D) through holes therein, a control unit acquiring measurement data relating to a brain activity while controlling the second light sending and receiving means, and a communication unit communicating with the main optical measurement device, that (C+D)>(A+B) is satisfied, and that the communication unit of the portable optical measurement device transmits the measurement data acquired by the control unit of the portable optical measurement device to the main optical measurement device.

System and Method of High-Frame Rate, Time-Resolved, Three-Dimensional Magnetic Resonance Angiograpy

A system and method for generating time-resolved 3D medical images of a subject includes acquiring a time series of two-dimensional (2D) data sets from a portion of the subject using a magnetic resonance imaging (MRI) system and reconstructing the time series of 2D data sets into a 2D time series of images of the subject having a given frame rate. The process also includes acquiring a time-independent, 3D volume of the portion of the subject and combining the 2D time series of images of the subject with the time-independent 3D volume of the subject to generate a set of time-dependent 3D volume images of the portion of the subject at the given frame rate.

Method and system for patient-specific modeling of blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

Method and system for patient-specific modeling of blood flow

Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.

NEURAL PROBE WITH OPTICAL STIMULATION CAPABILITY

A neural probe is disclosed for optically stimulating or silencing neurons and recording electrical responses to the stimulus. Using patterning techniques, an integral optical waveguide may be fabricated on the probe for transmitting neuron-affecting light from a light source to a probe tip. The probe tip may include one or more electrodes to receive electrical responses from stimulated neurons for recording or further processing. According to various embodiments, the disclosed neural probes may utilize multiple light sources simultaneously, switch between multiple light sources, or utilize a single light source to stimulate or silence multiple neuron locations simultaneously via multiple probe tips or via multiple light-emitting sites located along the length of the probe. Neural probes are thereby provided that have sufficient spatial resolution to accurately target, stimulate, and record the reaction of neurons, or as few as a single neuron, utilizing a slim, compact structure. 1. A neural probe , comprising:a probe body;a shank extending from the probe body to a tip;a light source for providing neuron-affecting light at said tip; andone or more recording electrodes attached to said tip for receiving electrical responses to the neuron-affecting light.2. A neural probe as defined in claim 1 , further comprising an optical waveguide extending from a source end at the probe body to an emitting end near said tip claim 1 , wherein the light source is in communication with the source end and the neuron-affecting light is provided at the tip by the emitting end.3. A neural probe as defined in claim 2 , wherein the light source comprises a fiber optic having a first end in communication with an external light source and a second end abutting the source end of the optical waveguide.4. A neural probe as defined in claim 2 , wherein the fiber optic and the optical waveguide each have an as-clad cross-sectional area claim 2 , and there is at least an order of magnitude ...

AUTOMATED RENAL EVALUATION SYSTEMS AND METHODS USING MRI IMAGE DATA

Renal screening systems include a circuit configured to electronically analyze MRI image data of a subject to evaluate renal function and generate a renal-risk report for a plurality of different therapeutic agents based on renal responses to test doses of each of the agents. 1. A renal evaluation system , comprising:a circuit comprising at least one processor configured to: (i) segment cortical and medullary regions of different MRI kidney image slices of a respective patient into defined sub-segments for volume analysis and associate borders of the defined sub-segments with a respective color; (ii) assess oxygenation and perfusion in the defined sub-segments before and after one or more agents are administered to a respective patient; and (iii) generate a color coded image of abdominal fat adjacent a respective kidney of a patient; andat least one display in communication with the circuit configured to display the color coded image of abdominal fat of a patient and at least one image slice of a segmented kidney with defined sub-segments with color borders.2. The system of claim 1 , wherein the defined sub-segments include a total kidney volume claim 1 , a medulla volume claim 1 , and a renal sinus volume claim 1 , and wherein the circuit is configured to analyze each kidney image slice having a slice thickness between about 3 mm to about 20 mm claim 1 , to calculate a cortical volume as equal to total kidney volume minus medulla volume and to calculate a medullary volume as equal to the medulla volume minus the renal sinus volume claim 1 , and wherein the circuit is configured to evaluate whether blood flow changes in response to administered agents preserve or alter renal cortex to medullary volume ratios.3. The system of claim 1 , wherein the circuit is configured to calculate blood flow and percent stenosis of at least one renal artery.4. The system of claim 1 , wherein the circuit is configured to identify whether the patient is likely to benefit or likely not ...

MAGNETIC RESONANCE IMAGING APPARATUS AND MAGNETIC RESONANCE IMAGING METHOD

A magnetic resonance imaging apparatus includes a collecting unit, a specifying unit, an acquiring unit and a calculating unit. The collecting unit collects a plurality of fluid images that are images of a fluid traveling though a subject. The specifying unit specifies a distance traveled by the fluid by using a difference image between a reference image that is one of the fluid images and each fluid image. The acquiring unit acquires an elapsed time corresponding to the traveled distance from pulse sequence information that is used to collect the fluid images. The calculating unit calculates a flow velocity of the fluid by dividing the traveled distance by the elapsed time. 1. A magnetic resonance imaging apparatus comprising:a collecting unit configured to collect a plurality of fluid images that are images of a fluid traveling through a subject;a specifying unit configured to specify a distance traveled by the fluid by using a difference image between a reference image that is one of the fluid images and each fluid image;an acquiring unit configured to acquire an elapsed time corresponding to the traveled distance from pulse sequence information that is used to collect the fluid images; anda calculating unit configured to calculate a flow velocity of the fluid by dividing the traveled distance by the elapsed time.2. The magnetic resonance imaging apparatus according to claim 1 , wherein the acquiring unit acquires the elapsed time corresponding to the traveled distance in accordance with a method of filling a k space used to generate the fluid images.3. The magnetic resonance imaging apparatus according to claim 2 , wherein the acquiring unit acquires claim 2 , as the elapsed time claim 2 , a BBTI (black-blood time to inversion) time from the pulse sequence information in a case of centric ordering in which phase encodes are arrayed from the center of the k space and the acquiring unit acquires claim 2 , as the elapsed time claim 2 , a value obtained from the ...

MAGNETIC RESONANCE IMAGING APPARATUS AND MAGNETIC RESONANCE IMAGING METHOD

A magnetic resonance imaging apparatus according to an exemplary embodiment includes a determining unit and an imaging unit. When a fluid traveling through a subject is imaged for multiple times at different phases, the determining unit determines a period on the time axis within which imaging is performed at intervals satisfying a predetermined temporal resolution. The imaging unit performs imaging for multiple times by the temporal resolution within the period. 1. A magnetic resonance imaging apparatus comprising:a determining unit configured to, when a fluid traveling through a subject is imaged for multiple times at different phases, determine a period on a time axis within which imaging is performed at intervals satisfying a predetermined temporal resolution; andan imaging unit configured to perform imaging for multiple times by the temporal resolution within the period.2. The magnetic resonance imaging apparatus according to claim 1 , wherein the determining unit performs pre-imaging for multiple times at intervals by a low temporal resolution below the predetermined temporal resolution over a whole period covering the period and claim 1 , on the basis of a plurality of images collected by the pre-imaging claim 1 , determines the period on the time axis within which imaging is performed at the intervals satisfying the predetermined temporal resolution.3. The magnetic resonance imaging apparatus according to claim 1 , further comprising a play controller configured to successively play the images claim 1 , which are collected by the imaging by the imaging unit for the multiple times claim 1 , in time series.4. The magnetic resonance imaging apparatus according to claim 2 , whereinthe determining unit performs, as the pre-imaging for the multiple times, ECG-Prep imaging to collect a plurality of images at different cardiac phases while changing a delay from a synchronization signal, displays on a display the images collected by the ECG-Prep imaging or a ...

SYSTEM, IMAGING SUITE, AND METHOD FOR USING AN ELECTRO-PNEUMATIC INSUFFLATOR FOR MAGNETIC RESONANCE IMAGING

Embodiments of the invention provide a system and method for using an electro-pneumatic insufflator for magnetic resonance imaging, such as for virtual colonoscopy. Embodiments of the invention further provide a MRI imaging suite and a method for distension of a body part to be imaged. As an alternative to the complete redesign of an electro-magnetic insufflator, embodiments of the current invention utilize a standard electro-pneumatic insufflator that operates in a location impervious to electromagnetic radiation using an electromagnetically inactive connection tube. 1. A magnetic resonance imaging (MRI) suite for performing MRI scanning of one or more organs requiring distention , the MRI suite comprising:a separate shielded area having a shield that substantially blocks magnetic and radio frequency (RF) radiation,an area outside the shielded area,an MRI scanner, and an electro-pneumatic insufflator, at least one container coupled to the insufflator and comprising a distension medium, and', 'an electromagnetically inactive connection tube coupled to the insufflator and comprising an insertion tip configured to be inserted into the rectum of the patient, the electromagnetically inactive connection tube configured to convey the distension medium from the insufflator and into the GI tract of the patient via the insertion tip, and, 'a system for distending at least a portion of the GI tract of a patient, the system comprisingwherein the insufflator is located in the area outside the shielded area, the MRI scanner is located in the separate shielded area, and the electromagnetically inactive connection tube extends through the shield, and wherein one end of the electromagnetically inactive connection tube is attached to the electro-pneumatic insufflator and is located in the area outside the shielded area, and the opposite end of the electromagnetically inactive connection tube including the insertion tip is located in the separate shielded area.2. The MRI suite of ...

MRI-Guided Medical Interventional Systems and Methods

An MRI-guided interventional system includes a trajectory guide frame for guiding an interventional device with respect to a patient in an MRI-guided procedure and including a base, a platform, a targeting cannula, and a stabilizer mechanism. The platform is mounted on the base and includes a support table and a moving plate that is translatable relative to the support table and the base along a translational axis. The targeting cannula is mounted on the moving plate for movement therewith and includes an elongate guide bore defining a trajectory axis. The stabilizer mechanism is operable to selectively control movement between the support table and the moving plate to stabilize a position of the targeting cannula with respect to the base. The frame is operable to translate the moving plate along the translational axis relative to the base to position the trajectory axis. The translational axis is transverse to the trajectory axis. 1. An MRI-guided interventional system for use with a body of patient and an interventional device , the system including: a base having a patient access aperture therein, wherein the base is configured to be secured to the body of the patient;', 'a platform mounted on the base and including a support table and a moving plate that is translatable relative to the support table and the base along a translational axis;', 'a targeting cannula mounted on the moving plate for movement therewith relative to the support table and the base, the targeting cannula including an elongate guide bore therethrough, the guide bore defining a trajectory axis and being configured to guide placement of the interventional device in vivo; and', 'a stabilizer mechanism operable to selectively control movement between the support table and the moving plate to stabilize a position of the targeting cannula with respect to the base;', 'wherein the trajectory guide frame is operable to translate the moving plate and thereby the targeting cannula along the ...

Modeling of pharmaceutical propagation

A method of delivering a contrast enhancing fluid to a patient using an injector system, including: determining at least one patient transfer function for the patient based upon data specific to the patient, the at least one patient transfer function providing a time enhancement output for a given input; determining a desired time enhancement output; using the at least one patient transfer function to determine an injection procedure input; and controlling the injector system at least in part on the basis of the determined injection procedure input.

Biological photometric device and biological photometry method using same

The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.

Holder and light measurement device employing same

Provided is a holder which comprises at least two probe mount portions into which a light-transmitting probe for emitting light from the tip thereof or a light-receiving probe for receiving light through the tip thereof is inserted from above and is to be put on the head of a subject, the holder being characterized by further comprising: a linear backbone portion that extends in a first direction that is perpendicular to the above-described direction from above; and at least two linear branch portions that extend in a second direction that is perpendicular to the above-described direction from above and is different from the first direction, wherein the lower end portions of the probe mount portions protrude from the lower surface of the backbone portion or a branch portion and are tapered.

SYSTEM FOR IDENTIFYING THE LOCATION OF A DEVICE WITHIN A PATIENT'S BODY IN ORDER TO LOCATE THE FOSSA OVALIS FOR TRANS-SEPTAL PROCEDURES

A system and method for identifying the location of a medical device within a patient's body may be used to localize the fossa ovalis for trans-septal procedures. The systems and methods measure light reflected by tissues encountered by an optical array. An optical array detects characteristic wavelengths of tissues that are different distances from the optical array. The reflectance of different wavelengths of light at different distances from an optical array may be used to identify the types of tissue encountered, including oxygenated blood in the left atrium as detected from the right atrium through the fossa ovalis. 1. A medical device for identifying the location of a medical device within a patient's body comprising:an intravascular catheter;an optical array comprising a light emitter and a plurality of receivers for detecting reflected light, wherein two or more of the plurality of receivers are each positioned at different distances from the emitter; anda spectrometer in communication with the emitter and the plurality of receivers.2. The medical device of claim 1 , wherein the optical array further comprises a face plate claim 1 , wherein the emitter and each of the plurality of receivers are located on the face plate.3. The medical device of claim 1 , wherein the catheter further comprises a lumen and the face plate is annular and surrounds an opening to the lumen at a distal region of the catheter.4. The medical device of claim 3 , wherein the catheter has a longitudinal axis and the annular face plate lies in a plane that is substantially orthogonal to the longitudinal axis of the catheter.5. The medical device of claim 4 , wherein the emitter and plurality of receivers are positioned radially around the lumen on the face plate.6. The medical device of claim 5 , wherein the plurality of receivers comprises at least a first receiver claim 5 , a second receiver claim 5 , and a third receiver.7. The medical device of claim 6 , wherein the first receiver ...

SYSTEMS AND METHODS FOR DETECTION AND PREDICTION OF BRAIN DISORDERS BASED ON NEURAL NETWORK INTERACTION

Systems and methods obtain functional connectivity data in the whole brain to detect and predict brain disorders. This whole brain data is regionalized and then manipulated to derive functional connectivity data sets that can be used to show measured functional connectivity changes. This whole brain data may also be analyzed to determine changes in functional activity in both increased and decreased neural network connectivity. By identifying and then quantifying the functional connectivity differences between healthy and diseased subjects, a classification for individual subjects can be made. 1. A system for classifying the brain of a subject into a class based on presence or progression or lack of a brain disorder , the system comprising:a processor operable to access time course image data from memory, the processor programmed to perform the steps ofa) acquiring with a medical imaging system time course image data from the brain of the subject;b) determining a functional connectivity in the brain of the subject between at least a set of functional regions of interest, from the time course image data acquired in step a);c) comparing the functional connectivity in the brain of the subject measured in step b) with at least one class classifier, the class classifier including an increased functional connectivity at the at least a set of functional regions of interest and/or a decreased functional connectivity at the at least a set of functional regions of interest; andd) classifying the subject into at least one class based on step c).2. The system as recited in in which the at least a set of functional regions of interest comprises at least a pair of functional regions of interest.3. The system as recited in in which the at least one class classifier is derived by detecting corresponding changes between different classes in training data.4. The system as recited in in which the functional regions of interest correlates to neurological functional regions claim 1 , ...

Mri-guided devices and mri-guided interventional systems that can track and generate dynamic visualizations of the devices in near real time

An MRI-guided medical device includes an elongated sheath, an elongated dilator, and an elongated needle. The sheath has a distal end, an opposite proximal end, and a central lumen extending between the proximal and distal ends. The sheath comprises MRI-compatible material and includes a tracking member located adjacent to the sheath distal end that is visible in an MRI image. The dilator comprises MRI-compatible material and is movably disposed within the sheath lumen. A distal end of the dilator is configured to extend outwardly from the sheath distal end and dilator includes at least one tracking member that is visible in an MRI image. The needle is movably disposed within the dilator lumen and is movable between stored and operative positions relative to the dilator. An RF shield may be coaxially disposed within the elongated sheath so as to surround a portion of the sheath central lumen.

Measurement of Anaplerotic Flux by Hyperpolarization Transfer

Methods and composition for metabolic imaging are provided. For example, in certain aspects, methods for hyperpolarization transfer combined with hyperpolarization are provided. Furthermore, the invention provides methods for detecting magnetic resonance signals for biological processes such as anaplerosis.

MRI-GUIDED DEVICES AND MRI-GUIDED INTERVENTIONAL SYSTEMS THAT CAN TRACK AND GENERATE DYNAMIC VISUALIZATIONS OF THE DEVICES IN NEAR REAL TIME

An MRI-compatible catheter includes an elongated flexible shaft having opposite distal and proximal end portions. A handle is attached to the proximal end portion and includes an actuator in communication with the shaft distal end portion that is configured to articulate the shaft distal end portion. The distal end portion of the shaft may include an ablation tip and includes at least one RF tracking coil positioned adjacent the ablation tip that is electrically connected to an MRI scanner. The at least one RF tracking coil is electrically connected to a circuit that reduces coupling when the at least one RF tracking coil is exposed to an MRI environment. Each RF tracking coil is a 1-10 turn solenoid coil, and has a length along the longitudinal direction of the catheter of between about 0.25 mm and about 4 mm. 1. An MRI-compatible catheter , comprising:an elongated flexible shaft having a distal end portion and an opposite proximal end portion, wherein at least a portion of the flexible shaft is sized and configured to enter a patient during an MRI-guided medical procedure;an electrical connector interface attached to the shaft and configured to be in electrical communication with an MRI scanner;at least one RF tracking coil positioned adjacent the flexible shaft distal end portion, wherein the at least one tracking coil includes a conductive lead extending between the at least one RF tracking coil and the electrical connector interface and is configured to electrically connect the at least one tracking coil to an MRI scanner; andan ablation tip at the flexible shaft distal end portion, wherein an RF conductor extends longitudinally within the shaft to the electrical connector interface and connects the ablation tip to an RF generator.2. The device of claim 1 , further comprising a handle attached to the shaft proximal end portion claim 1 , and wherein the handle comprises a circuit electrically connected to the at least one RF tracking coil claim 1 , wherein the ...

METHOD AND MAGNETIC RESONANCE APPARATUS TO MEASURE STRUCTURES OF THE HUMAN BRAIN

In a method to measure characteristic structure sizes of the human brain, which structure sizes can be used as biomarkers for a diagnosis of Alzheimer's, using a magnetic resonance device, manual and/or automatic localization of the hippocampus takes place in a preliminary magnetic resonance acquisition, followed by selection of at least one measurement axis that proceeds through the hippocampus. For each selected measurement axis, magnetic resonance data are acquired for a longitudinal, in particular rod-shaped, acquisition region proceeding along the measurement axis. Determination of the spatially resolved structure sizes is implemented from the magnetic resonance data. 1. A method to measure a characteristic size of an anatomical structure of a human brain , comprising:operating a magnetic resonance (MR) data acquisition unit to obtain a preliminary magnetic resonance data set of a human brain in which the hippocampus is represented;using a processor, localizing the hippocampus in said preliminary magnetic resonance data set;using said processor, selecting at least one measurement axis that proceeds through the hippocampus;for each selected measurement axis, operating said MR data acquisition unit to acquire diagnostic magnetic resonance data from a longitudinal acquisition region of the brain, said longitudinal acquisition region comprising a longitudinal extent along said measurement axis and having an extent perpendicular to said longitudinal extent that is substantially shorter than said longitudinal extent; andusing said processor, determining a spatially-resolved structural size of a structure represented in said MR data acquired from said acquisition region that is a biomarker for diagnosis of a presence of Alzheimer's disease.2. A method as claimed in comprising automatically claim 1 , in said processor claim 1 , localizing the hippocampus in said preliminary magnetic resonance data set.3. A method as claimed in comprising automatically claim 1 , in said ...

SYSTEM AND METHOD FOR TASK-LESS MAPPING OF BRAIN ACTIVITY

A computing device for use in a system for mapping brain activity of a subject includes a processor. The processor is programmed to select a plurality of measurements of brain activity that is representative of at least one parameter of a brain of the subject during a resting state. Moreover, the processor is programmed to compare at least one data point from each of the measurements with a corresponding data point from a previously acquired data set from at least one other subject. The processor is also programmed to produce at least one map for each of the measurements based on the comparison of the resting state data point and the corresponding previously acquired data point. The processor may also be programmed to categorize the brain activity in a plurality of networks in the brain based on the map. 1. A computing device for use in a system for task-less mapping of brain activity of a subject , the computing device comprising a processor programmed to:select a plurality of measurements of brain activity that is representative of at least one parameter of a brain of the subject during a resting state;compare at least one data point from each of the plurality of measurements with a corresponding data point from a previously acquired data set from at least one other subject;produce at least one map for each of the plurality of measurements based on the comparison of the at least one resting state data point and the corresponding previously acquired data point; andcategorize the brain activity in a plurality of networks in the brain based on the at least one map.2. A computing device in accordance with claim 1 , wherein the processor is programmed to select a plurality of voxels from an image of the brain.3. A computing device in accordance with claim 1 , further comprising a communication interface coupled to the processor and configured to receive at least one signal representative of the plurality of measurements of the brain activity.4. A computing device in ...

PLANNING SYSTEM FOR TARGETING TISSUE STRUCTURES WITH ULTRASOUND

The disclosed subject matter provides systems and methods for targeting tissue structures and applying ultrasound thereto. A method according to the disclosed subject matter for targeting a tissue structure using corresponding tissue structure image data includes inputting the tissue structure image data into a targeting simulator, determining acoustic properties of the tissue structure from the corresponding tissue structure image data, and utilizing the determined acoustic properties to align a simulated transducer with the tissue structure such that the tissue structure is targeted. The method can further include acquiring the tissue structure image data, aligning the image data with an atlas of a body structure encompassing the tissue structure and/or selecting parameters of the simulated transducer such that a focal region of an ultrasound wave generated by the simulated transducer targets the tissue structure. 1. A method for targeting a tissue structure using corresponding tissue structure image data , comprising:receiving the tissue structure image data into a targeting simulator;determining one or more acoustic properties of the tissue structure from the corresponding tissue structure image data; andutilizing the determined one or more acoustic properties to align a simulated transducer with the tissue structure such that the tissue structure is targeted.2. The method of claim 1 , further comprising acquiring the tissue structure image data.3. The method of claim 2 , wherein the acquiring comprises acquiring a CT scan of at least the tissue structure.4. The method of claim 2 , wherein the acquiring comprises acquiring an MRI of at least the tissue structure.5. The method of claim 1 , further comprising aligning the tissue structure image data with an atlas of a body structure encompassing the tissue structure.6. The method of claim 1 , further comprising selecting parameters of the simulated transducer such that a focal region of an ultrasound wave ...

MRI-GUIDED CATHETERS

An MRI-compatible catheter that reduces localized heating due to MR scanner-induced currents includes an elongated flexible shaft having a distal end portion and an opposite proximal end portion. A handle is attached to the proximal end portion and includes an electrical connector interface configured to be in electrical communication with an MRI scanner. One or more RF tracking coils are positioned adjacent the distal end portion of the shaft. Each RF tracking coil includes a conductive lead, such as a coaxial cable, that extends between the RF tracking coil and the electrical connector interface and electrically connects the RF tracking coil to an MRI scanner. In some embodiments of the present invention, the conductive lead has a length sufficient to define an odd harmonic/multiple of a quarter wavelength of the operational frequency of the MRI Scanner, and/or includes a series of pre-formed back and forth segments along its length. 1. An MRI-compatible catheter , comprising:an elongated flexible shaft having a distal end portion, and an opposite proximal end portion;an electrical connector interface configured to be in electrical communication with an MRI scanner; andat least one RF tracking coil positioned adjacent the distal end portion of the flexible shaft, wherein the at least one tracking coil includes a conductive lead extending between the at least one RF tracking coil and the electrical connector interface and configured to electrically connect the at least one tracking coil to the MRI scanner, and wherein the conductive lead includes a series of pre-formed back and forth segments along its length.2. The catheter of claim 1 , wherein the conductive lead is a coaxial cable.3. The catheter of claim 1 , wherein the at least one RF tracking coil comprises a plurality of tracking coils claim 1 , each attached to a separate conductive lead claim 1 , and wherein each conductive lead includes a series of back and forth segments along its length.4. The catheter ...

SYSTEMS AND METHODS FOR BREAST IMAGING

Systems and methods for breast imaging are provided. One includes a gantry, a first nuclear medicine detector mounted to the gantry and having a multi-bore collimator coupled thereto, and a second nuclear medicine detector mounted to the gantry and having a multi-bore collimator coupled thereto. The first and second nuclear medicine detectors are configured to be independently titled with respect to a breast therebetween. 1. A breast imaging system comprising:a gantry;a first nuclear medicine detector mounted to the gantry and having a multi-bore collimator coupled thereto; anda second nuclear medicine detector mounted to the gantry and having a multi-bore collimator coupled thereto, wherein the first and second nuclear medicine detectors are configured to be independently titled with respect to a breast therebetween.2. The breast imaging system of claim 1 , wherein the first and second nuclear medicine detectors are configured to be titled transverse to the breast.3. The breast imaging system of claim 1 , wherein the first and second nuclear medicine detectors are configured to be titled one of towards or away from the breast in a plane perpendicular to a front of the breast.4. The breast imaging system of claim 1 , wherein the collimators are multi-bore claim 1 , parallel-hole collimators.5. The breast imaging system of claim 1 , wherein the collimators are multi-bore claim 1 , slanted-hole collimators.6. The breast imaging system of claim 5 , wherein the slanted-hole collimators are slanted obliquely to each other.7. The breast imaging system of claim 5 , wherein the slant angle for the bores of the collimator coupled to the first nuclear medicine detector is different than the slant angle of the bores of the collimator coupled to the second nuclear medicine detector.8. The breast imaging system of claim 1 , further comprising a biopsy device claim 1 , wherein the first and second nuclear medicine detectors are configured to titled such that a distance between ...

Method and system for automatically setting a landmark for brain scans

A method, system and apparatus for automatically setting a landmark for brain scans are described. In one embodiment, a method for medical image processing is described. The method comprises obtaining, by an imaging device, at least one image of a head of a subject. In addition, the method also comprises identifying, by a computer-based system, a reference feature in the at least one image associated with the head. The method also comprises automatically setting, by the computer-based system, a landmark based, at least in part, upon the reference feature.

SMALL TISSUE PROPERTY CHANGE DETECTION IN MAGNETIC RESONANCE GUIDED INTERVENTION

Small tissue property change detection is provided for magnetic resonance (MR) guided intervention. T1 changes from before and after treatment are compared. The comparison identifies locations of possible change. The comparison is performed for different times, one before and one after a zero-crossing of a signal intensity time curve. Due to the characteristics of the T1 mapping, common locations from the different times will have reversed contrast. Clustering and this reversal are used to distinguish the treatment region from noise. 1. A method for small tissue property change detection in magnetic resonance (MR) guided intervention , the method comprising:acquiring, with an MR scanner, a MR intensity curve of tissue response over time in response to an inversion pulse;determining, with a processor, a first time before a zero crossing of the MR intensity curve and a second time after the zero crossing;identifying first locations from a comparison of an MR T1 map for the first time from before the MR guided intervention to an MR T1 map for the first time from after therapy in the MR guided intervention;identifying second locations from a comparison of an MR T1 map for the second time from before the MR guided intervention to an MR T1 map for the second time from after therapy in the MR guided intervention;locating tissue common to the first and second locations and with a reversed contrast for the first time as compared to the second time; andgenerating an image indicating the common tissue.2. The method of wherein acquiring the MR intensity curve comprises:acquiring frames of data in a series of inversion recovery scanning before the MR guided intervention; andsampling the intensities from the frames of data.3. The method of wherein acquiring the frames of data comprises acquiring with a Look-Locker scan.4. The method of wherein the MR T1 maps from before and after the MR guided intervention are selected from frames of data representing a slice of the tissue claim ...

X-ray imaging apparatus, medical image processing apparatus and x-ray imaging method

According to one embodiment, an X-ray imaging apparatus includes an angle acquisition unit and an imaging unit. The angle acquisition unit is configured to acquire an inclined angle of an aorta of an object on a reference image. The imaging unit is configured to display an X-ray image with rotating an angle so as to make a travel direction of the aorta to be a horizontal direction, a vertical direction or a predetermined direction corresponding to a craft. The angle is rotated based on the inclined angle of the aorta.

MULTI-MODAL IMAGING OF BLOOD FLOW

The application features methods, devices, and systems for measuring blood flow in a subject. The computer-implemented methods include receiving functional magnetic resonance imaging (fMRI) data that provides information on at least one of volume or oxygenation of blood at one or more locations in a body over a first predetermined length of time. The methods also include receiving near-infrared spectroscopic (NIRS) imaging or measurement data representing at least one of blood concentration or oxygenation at a first portion of the body over a second predetermined length of time. The methods further include deriving, from the fMRI data corresponding to a second portion of the body, a time varying data set representing changes in blood oxygenation or volume or both blood oxygenation and volume at the second portion over the first predetermined length of time and determining, by a computing device, a time delay and a value of a similarity metric corresponding to a part of the spectroscopic imaging data that most closely matches the time varying data set. The time delay represents a difference between a first time in which blood flows from a third portion in the body to the first portion and a second time in which blood flows to the second portion from the third portion. The value of the similarity metric represents an amount of blood at the second portion. An estimate of a characteristic of at least one of blood flow or blood volume in the second portion at a given time is determined based on the time delay and the value of the similarity metric. 136-. (canceled)37. A computer-implemented method for measuring at least one of blood flow or volume in a subject , the method comprising:receiving functional magnetic resonance imaging (fMRI) data that provides information on at least one of volume or oxygenation of blood at one or more locations in a body over a first predetermined length of time;receiving spectroscopic measurement data representing at least one of blood ...

MAGNETIC RESONANCE IMAGING APPARATUS

A magnetic resonance imaging apparatus includes a magnet having two poles and a wall connecting the poles; the poles delimiting a patient-imaging space; and a table which is slidably connected to one of the two poles between the two poles and which table extends substantially parallel to the two poles; a drive for displacing the table relative to the magnet; a lock for locking the table in a selected position relative to the magnet; a drive for rotating the magnet about the axis; the table connected to the magnet such that the table rotates with the magnet when the magnet rotates about the axis; the magnet and the table being rotatable from a position in which the poles and the table are horizontal to a position in which the table and the poles are vertical. 1. A magnetic resonance imaging apparatus , comprising:a magnet having a two opposite and spaced apart poles and a column or wall transverse to the poles and connecting the poles;the poles defining two opposite walls delimiting a patient-imaging space, the two opposite walls extending along substantially parallel planes which are substantially perpendicular to a vertical plane;the magnet being supported rotatably along a central horizontal axis of the transverse wall or column, the central horizontal axis of the transverse wall or column thereby defining an axis of rotation passing between the two poles of the magnet;a drive provided for rotating the magnet about the axis;a patient positioning table being connected to the magnet such that the table rotates with the magnet when the magnet rotates about said axis of rotation;the magnet and the table being rotatable from a position in which the poles and the table are substantially horizontal to a position in which the table and the poles are substantially vertical, and vice versa; andthe rotation of the table and the magnet are locked together by a lock.2. The magnetic resonance imaging apparatus according to in which the magnet generates a static magnetic field ...

METHOD OF DESIGNING ORTHOPEDIC IMPLANTS USING IN VIVO DATA

A reconfigurable orthopedic implant trial comprising: (a) a first orthopedic component; (b) a second orthopedic component that includes a second sensor on a second articulating surface thereof, the second orthopedic component configured to removably mount to the first orthopedic component; (c) a third orthopedic component that includes a third sensor on a third articulating; surface thereof, the third orthopedic component configured to removably mount to the first orthopedic component, where the second sensor and the third sensor are configured to generate kinematic data. 19-. (canceled)10. A reconfigurable orthopedic implant trial comprising:a first orthopedic component;a second orthopedic component that includes a second sensor on a second articulating surface thereof, the second orthopedic component configured to removably mount to the first orthopedic component;a third orthopedic component that includes a third sensor on a third articulating surface thereof, the third orthopedic component configured to removable mount to the first orthopedic component;wherein the second sensor and the third sensor are configured to generate kinematic data.11. The reconfigurable orthopedic implant trial of claim 10 , wherein:the first orthopedic component comprises at least one of a tibial tray and a tibial tray insert;the second orthopedic component includes a first tibial post; andthe third orthopedic component includes a second tibial post;the first tibial post differs from the second tibial post in at least one of size, shape, and material composition.12. The reconfigurable orthopedic implant trial of claim 10 , wherein:the first orthopedic component comprises at least one of a tibial tray and a tibial tray insert;the second orthopedic component includes a first condyle receiver; andthe third orthopedic component includes a second condyle receiver.1317-. (canceled)18. The reconfigurable orthopedic implant trial of claim 10 , wherein:the first orthopedic component that ...

System and Method for Detecting, Recording, and Treating Persons with Traumatic Brain Injury

A system and method for detecting information related to traumatic brain injury is presented, comprising a skull cap, adapted to be worn by an individual, and a sensor array coupled to the skull cap. The sensor array comprises one or more multi-axial accelerometers, adapted to measure linear, rotational, and/or angular forces, one or more gyroscopes, and a sensor array computer, coupled to the accelerometers and gyroscopes, including a processor for receiving data from the accelerometers and gyroscopes pertaining to the individual's vital, and a memory for storing data. The sensor array computer is adapted to compare the data to historical data for the individual to determine if a traumatic brain injury has occurred, wherein the historical data includes information relating to the frequency of injuries to the individual's head over a given time period, and to calculate acceleration from linear forces. The headgear preferably comprises a plurality of layers. 1. A system for detecting information related to traumatic brain injury comprising:a skull cap, adapted to be worn by the individual; one or more multi-axial accelerometers, adapted to measure linear, rotational, and/or angular forces;', 'one or more gyroscopes;', a processor for receiving data, including from said one or more accelerometers and said one or more gyroscopes, pertaining to vital signs of the individual; and', 'a memory for storing said data;, 'a sensor array computer, coupled to said one or more accelerometers and said one or more gyroscopes, including], 'a sensor array coupled to said skull cap comprisingwherein said sensor array computer is adapted to compare said data to historical data for the individual stored in said sensor array memory to determine if a traumatic brain injury has occurred; andwherein said historical data includes information relating to the frequency of injuries to the individual's head over a given time period.2. The system as claimed in claim 1 , wherein said sensor array ...

Apparatus and program for evaluating biological function

An apparatus and a program are provided which are capable of simultaneously measuring, evaluating, imaging and displaying the biological function of sites with different biological functions, such as the brain and the muscle, different parts of the brain or different muscle locations, using near-infrared spectroscopy. In an apparatus for evaluating biological function K, physiological indices, including parameters derived from changes in deoxyhemoglobin concentration and changes in oxyhemoglobin concentration, are calculated by a calculating part of a controller. To measure simultaneously, evaluate, image and display the biological functions of sites with different biological function, such as the brain and the muscle, different parts of the brain or different muscle locations, these physiological indices from different sites of the living body are adjusted in such a way that they can be compared with each other by the calculating part and displayed by a display part. 1. An apparatus for evaluating biological function that is an apparatus for evaluating biological function having a plurality of living body probes for irradiating light to and receiving emitted light from a plurality of sites with different biological functions of a living body , and an apparatus body for entering light information detected by means of said plurality of living body probes and performing calculation , control and memory operations , and utilizing the near-infrared spectroscopy method , wherein said plurality of sites of said living body with different biological functions include at least a brain site and a muscle site , wherein said apparatus body comprising:a calculating part for calculating amounts of change in oxyhemoglobin concentration and amounts of change in deoxyhemoglobin concentration and/or physiological indices including a variety of parameters derived from the relationships between them, based on light information from said plurality of living body probes;an adjusting ...

MAGNETIC FIELD MEASURING APPARATUS AND CELL ARRAY

A magnetic field measuring apparatus includes a cell array which includes plural cells different in size of detection surface through which a magnetic flux passes when the cells are arranged in a magnetic field of a measurement object, a medium which is enclosed inside each of the plural cells and rotates a light polarization plane according to an intensity of the magnetic field, an irradiator to irradiate a light to the detection surface of each of the cells, and a detector to detect a rotation angle of a polarization plane of the light passing through each of the cells. 1. A magnetic field measuring apparatus comprising:a cell array which includes a plurality of cells different in size of detection surface through which a magnetic flux passes when the cells are arranged in a magnetic field of a measurement object;a medium which is enclosed inside each of the plurality of cells and rotates a light polarization plane according to an intensity of the magnetic field;an irradiator to irradiate a light to the detection surface of each of the cells; anda detector to detect a rotation angle of a polarization plane of the light passing through each of the cells.2. The magnetic field measuring apparatus according to claim 1 , wherein the plurality of cells includes first cells and second cells having larger detection surfaces than the first cells claim 1 , and the first cells are arranged at a higher density than the second cells.3. The magnetic field measuring apparatus according to claim 2 , wherein the plurality of cells are arranged to cover a generation source of the magnetic field of the measurement object from a plurality of directions.4. The magnetic field measuring apparatus according to claim 3 , whereinthe generation source is a heart of a subject, andthe first cells included in the plurality of cells are arranged on a front surface side of the subject.5. The magnetic field measuring apparatus according to claim 4 , wherein the second cells among the plurality of ...

COMPARTMENTAL ANALSYS SYSTEM, COMPARTMENTAL ANALYSIS METHOD, COMPARTMENT ANALYZER, PROGRAM, AND RECORDING MEDIUM

One object of the present invention is to perform compartmental analysis of the dynamics of a tracer in the brain, and the present invention provides a compartmental analysis system including a measurement apparatus that measures the strength of an electromagnetic wave from a tracer and a compartmental analyzer that performs compartmental analysis of the dynamics of the tracer in the brain on the basis of the strength of the electromagnetic wave, wherein the compartmental analyzer includes a rate constant calculation unit that calculates a rate constant when the tracer moves between compartments on the basis of the strength of an electromagnetic wave in a first compartment corresponding to the cerebral blood vessel in the brain or an input function in the first compartment, the strength of an electromagnetic wave in a second compartment corresponding to the brain tissue in the brain, and the strength of an electromagnetic wave in a third compartment corresponding to the cerebral sulcus or cerebral ventricle in the brain. 1. A compartmental analysis system that performs compartmental analysis of dynamics of a tracer in a brain , including:a measurement apparatus that measures a strength of an electromagnetic wave from the tracer in the brain; anda compartmental analyzer that performs compartmental analysis of dynamics of the tracer in the brain on the basis of the strength of the electromagnetic wave from the tracer in the brain measured by the measurement apparatus,wherein the compartmental analyzer includes a rate constant calculation unit that calculates a rate constant when the tracer moves between the compartments on the basis of a strength of an electromagnetic wave in a first compartment corresponding to a cerebral blood vessel in the brain measured by the measurement apparatus or an input function in the first compartment, a strength of an electromagnetic wave in a second compartment corresponding to brain tissue in the brain measured by the measurement ...

METHOD FOR DETECTING HEMATOMA, PORTABLE DETECTION AND DISCRIMINATION DEVICE AND RELATED SYSTEMS AND APPARATUSES

Featured are methods, apparatus and devices for detecting a hematoma in tissue of a patient. In one aspect, such a method includes emitting near infrared light continuously into the tissue from a non-stationary near infrared light emitter and continuously monitoring the tissue using a non-stationary probe so as to continuously detect reflected light. The near infrared light is emitted at two distances from a brain of the patient, so the emitted light penetrates to two different depths. Such a method also includes applying a ratiometric analysis to the reflected light to distinguish a border between normal tissue and tissue exhibiting blood accumulation. 1. A method for detecting a hematoma , comprising the step(s) of:emitting near infrared light and directing the emitted light towards tissue of a patient;measuring reflected light corresponding to two depths of penetration;obtaining a ratiometric measure of the reflected light corresponding to the two depths of penetration;determining from the obtained ratiometric measure at least the presence of a blood event, the blood event being representative of a blood-tissue injury.2. The method of claim 1 , further comprising the step(s) of:moving an emitter of the near infrared light and a reflected light detection section for detecting the reflected light along an external surface of the tissue; andperforming said steps of emitting, measuring and determining during said step of moving.3. The method of claim 1 , wherein said ratiometric measure is representative of a ratio of densities representing the reflected light of the two penetration depths.4. The method of claim 3 , wherein said determining includes evaluating the ratiometric measure to distinguish between normal tissue and tissue exhibiting blood accumulation.5. The method of claim 1 , wherein the blood event is at least one of an intracranial arachnoid hemorrhage a subdural hematoma or an epidural hematoma.6. The method of claim 1 , further comprising the step(s) ...

MAPPING SYSTEM AND METHOD FOR MEDICAL PROCEDURES

A system and method for mapping interluminal structures includes an elongated flexible instrument (). An optical shape sensing device () is disposed within the flexible instrument and is configured to determine a shape of the flexible instrument relative to a reference. The shape sensing device is configured to collect information based on its configuration to map an interluminal structure during a procedure. An imaging enabled ablation device () is mounted at or near a distal end portion of the flexible instrument. 1. A system for mapping interluminal structures , comprising:{'b': '102', 'an elongated flexible instrument ();'}{'b': 152', '154, 'an optical shape sensing device (, ) disposed within the flexible instrument and configured to determine a shape of the flexible instrument relative to a reference, the shape sensing device configured to collect information based on its configuration to map an interluminal structure during a procedure; and'}{'b': '117', 'an imaging enabled ablation device () mounted at or near a distal end portion of the flexible instrument.'}2152154154. The system as recited in claim 1 , wherein the optical shape sensing device includes an optical fiber () having at least one of Fiber Bragg Gratings (FBGs) () and a Rayleigh scatter interrogation setup () for sensing strain in the fiber.3152154. The system as recited in claim 1 , wherein the optical shape sensing device includes an area of higher sensitivity by including an area with a higher number of optical fibers () having optical strain sensors ().4. The system as recited in claim 1 , wherein the optical shape sensing device includes one of a spiral shape claim 1 , a ring shape and a loop shape.5. The system as recited in claim 1 , wherein the reference includes one of a position on the flexible instrument and an anatomical reference.6102. The system as recited in claim 1 , wherein the flexible instrument () includes one of a catheter and an endoscope.7. A system for mapping ...

Magnetic resonance imaging apparatus, magnetic field adjustment implement for magnetic resonance imaging apparatus, magnetic resonance imaging method, and method of adjusting magnetic field for magnetic resonance imaging apparatus

According to one embodiment, a magnetic field adjustment implement for a magnetic resonance imaging apparatus includes a magnetic field adjustment unit and a placing unit. The magnetic field adjustment unit is configured to improve a uniformity of a static magnetic field formed by a magnet of the magnetic resonance imaging apparatus. The static magnetic field is formed under an influence of a circumstance in a shield room in which the magnet is placed. The magnetic field adjustment is placed outside the magnet. The placing unit is configured to place the magnetic field adjustment unit outside the magnet.

Mri using faster multiplexed echo planar imaging (epi) pulse sequences

An MRI scanner and an MRI method that effectively reduce the inherent difference in timing of TE in the SIR images by using alternating polarity of the slice selective gradient pulse Gs and corresponding alternate polarity in RF phase offset in the excitation pulse. By using alternating polarity selective gradients, the refocusing gradient pulse on the Gs axis can be eliminated between the excitation pulses so that the time spacing between the multiple SIR excitation pulses is reduced, and therefore the time delay between onset of slice signal decay is reduced. This results in an earlier possible TE of the first excited slice, hence less signal decay and higher SNR, and overall the TE of different slices can be more nearly the same.

System and method for monitoring a retail environment using video content analysis with depth sensing

A method and system for monitoring a retail environment by performing video content analysis based on two-dimensional image data and depth data are disclosed. Accuracy in customer actions to provide assistance, change marketing behavior, safety and theft, for example, is increase by analyzing video containing two-dimensional image data and associated depth data. Height data may be obtained from depth data to assist in object detection, object classification (e.g., detection a customer or inventory) and/or event detection.

System and method for video content analysis using depth sensing

A method and system for performing video content analysis based on two-dimensional image data and depth data are disclosed. Video content analysis may be performed on the two-dimensional image data, and then the depth data may be used along with the results of the video content analysis of the two-dimensional data for tracking and event detection.

Apparatus and method for decoding sensory and cognitive information from brain activity

Decoding and reconstructing a subjective perceptual or cognitive experience is described. A first set of brain activity data produced in response to a first brain activity stimulus is acquired from a subject using a brain imaging device and converted into a corresponding set of predicted response values. A second set of brain activity data produced in response to a second brain activity stimulus is acquired from a the subject and decoded using a decoding distribution and the probability the second set of brain activity data corresponds to said predicted response values is determined. The second set of brain activity stimuli is then reconstructed based on the probability of correspondence between the second set of brain activity data and the predicted response values.

SYSTEM AND METHOD FOR PHASE CONTRAST IMAGING WITH IMPROVED EFFICIENCY

A system and method is provided for magnetic resonance angiography (MRA) that includes performing a pulse sequence using the MRI system, the pulse sequence including a phase-based flow encoding to collect a time-series of image data from the portion of the vasculature of the subject and identifying at least a portion of the time series of image data corresponding to a period of reduced flow through the portion of the vasculature. The portion of the time series of image data is subtracted from the time series of image data to create a time series of images of the portion of the vasculature having background tissue surrounding the portion of the vasculature substantially suppressed. 1. A method acquiring a magnetic resonance angiography (MRA) image of a portion of a vasculature of a subject using a magnetic resonance imaging (MRI) system , the method comprising:performing a pulse sequence using the MRI system, the pulse sequence including a phase-based flow encoding to collect a time-series of image data from the portion of the vasculature of the subject;identifying at least a portion of the time series of image data corresponding to a period of reduced flow through the portion of the vasculature; andsubtracting the portion of the time series of image data from the time series of image data to create a time series of images of the portion of the vasculature having background tissue surrounding the portion of the vasculature substantially suppressed.2. The method of wherein identifying at least a portion of the time series of image data includes selecting at least one image frame to create a subtraction image.3. The method of wherein subtracting includes subtracting the subtraction image from each image frame reconstructed from the time series of image data.4. The method of wherein identifying at least a portion of the time series of image data includes selecting multiple image frames and averaging the multiple image frames to create a subtraction image.5. The method ...

Method for producing an electrophysiological map of the heart

Methods and systems for producing an electrophysiological map of a heart of a patient are disclosed. An example method may include determining a target location and an orientation of a catheter tip, confirming that the tip is located at the target location, measuring the heart parameter value at each of the target locations, and superimposing a plurality of representations of the heart parameter value. Confirmation that the tip of the catheter is located at a target location can be accomplished by comparing the current location of the tip with the target location, a corresponding heart parameter value being measured at each of the target locations by a heart parameter sensor, and the representations of the heart parameter value being superimposed on an image of the heart at the target location to produce the electrophysiological map. 1. A method for producing an electrophysiological map of a heart , the method comprising:reconstructing a three-dimensional model of the heart from a plurality of two-dimensional images, wherein a coordinate system of the three-dimensional model is registered with a medical positioning system coordinate system;for each of a plurality of target points within the heart, determining a target point location associated with the three-dimensional model and a respective target probe orientation at which a heart parameter value is to be measured;for each target point, confirming that a probe of a catheter is located at the target point location by comparing a currently detected location of the probe with the respective target point location;for each target point, confirming that the probe is oriented at the probe orientation by comparing the currently detected orientation of the probe with the respective target probe orientation;for each target point, measuring the heart parameter value with a heart parameter sensor; andproducing the electrophysiological map.2. The method according to claim 1 , wherein the coordinate system of the three- ...

MOVING OBJECT CONTOUR EXTRACTION APPARATUS, LEFT VENTRICLE IMAGE SEGMENTATION APPARATUS, MOVING OBJECT CONTOUR EXTRACTION METHOD AND LEFT VENTRICLE IMAGE SEGMENTATION METHOD

According to one embodiment, a moving object contour extraction apparatus includes a contour acquisition unit and a contour correction unit. The contour acquisition unit is configured to acquire a contour of a moving object in each image slice. The contour correction unit is configured to correct the contours of the moving object in image slices of at least one image slice time series based on motion trend information of the moving object in each of a plurality of image slice time series. 1. A moving object contour extraction apparatus for extracting from a three-dimensional image time series contours of a moving object which performs a deforming motion , the three-dimensional image time series comprising a plurality of three-dimensional images acquired at a plurality of time points , each of the three-dimensional images consisting of a plurality of parallel two-dimensional image slices , and the two-dimensional image slices located at the same location in the plurality of three-dimensional images forming an image slice time series , the apparatus comprising:a contour acquisition unit configured to acquire a contour of the moving object in each image slice; anda contour correction unit configured to correct the contours of the moving object in the image slices of at least one image slice time series based on motion trend information of the moving object in each of a plurality of the image slice time series.2. The apparatus according to claim 1 , wherein the contour correction unit comprises:a motion trend determination unit configured to determine motion trend information of the moving object in each image slice time series;a similarity calculation unit configured to calculate a similarity between the motion trend information of the moving object in each image slice time series and reference motion trend information of the moving object; anda correction execution unit configured to correct the contours of the moving object in the image slices of a certain image ...

SYSTEM AND METHOD FOR HOME HEALTH CARE MONITORING

A home health care monitoring method and system are disclosed. In one embodiment, a method includes: capturing a plurality of video sequences from a plurality of respective cameras disposed in different locations within a patient's home, including capturing two-dimensional image data and depth data for each video sequence; defining a plurality of events to monitor associated with the patient, the events including, during a predetermined time period, at least (1) the patient's body being in a particular position for at least a predetermined amount of time; performing depth-enhanced video content analysis on the plurality of video sequences to determine whether the event (1) has occurred. The video content analysis may include: for each of at least two cameras: automatically detecting a human object based on the two-dimensional image data; using the depth data to confirm whether the human object is in the particular position; and based on the confirmation, tracking an amount of time that the human object is in the particular position; and then determining that the event (1) has occurred based on the collective tracked amount of time. 1. A method of monitoring the health of a patient in the patient's home , the method comprising:capturing a plurality of video sequences from a plurality of respective cameras disposed in different locations within the patient's home, including capturing two-dimensional image data and depth data for each video sequence;associating the depth data with the video sequences as metadata;setting a plurality of events to monitor associated with the patient, the events defined to include actions captured from at least two of the plurality of cameras; automatically detecting a potential human object from the video sequences based on the two-dimensional image data;', 'using the depth data to determine a size and position of the potential human object;', 'based on the size of the potential object, confirming that the potential human object is an ...

Biomarkers for acute ischemic stroke

The present invention provides methods and compositions for the diagnosis of acute ischemic stroke. The invention further provides methods and compositions for distinguishing acute ischemic stroke from other forms of stroke and TIAs and “stroke mimic” events. Moreover, methods and compositions are provided to facilitate the treatment of acute ischemic stroke patients.

Dynamic Optoacoustic Angiography of Peripheral Vasculature

Provided herein are systems and methods for dynamic optoacoustic imaging of the peripheral vasculature. The system generally comprises a short pulse laser, a fiberoptic laser light delivery system, and imaging module, a scanning system, and electronics/computer system for system control and three-dimensional and two-dimensional optoacoustic image visualization. A method is provided for optoacoustic imaging of an appendage using the dynamic optoacoustic imaging system where an appendage of a subject is imaged under conditions of normal, maximum and minimum tolerable temperatures and displaying differential anatomical images of peripheral vasculature in the appendage and functional diagnostic parameters as a function of time and temperature. From this data medical conditions of the appendage may be diagnosed. 1. An optoacoustic imaging system for dynamic angiography comprising:means for delivering optical energy to a volume of interest on a subject;means for imaging the volume of interest over a range of temperatures tolerable by the subject; andmeans for producing two- or three-dimensional angiographic images of the volume of interest.2. The optoacoustic imaging system of claim 1 , further comprising means for ultrasound imaging of the volume.3. The optoacoustic imaging system of claim 2 , wherein the ultrasound is electrically generated or laser generated.4. The optoacoustic imaging system of claim 1 , wherein the means for delivering optical energy comprises:a short pulse laser operable at one or more wavelengths; anda fiberoptic delivery system optically connected to the laser.5. The optoacoustic imaging system of claim 4 , wherein the one or more wavelengths comprise the visible and near-infrared spectrum claim 4 , and wherein spectral bands are deliverable in a sequence or toggled.6. The optoacoustic imaging system of claim 4 , wherein the means for imaging the extremity over a range of temperatures comprises: a vessel shaped to receive the volume of interest;', ...

METHODS AND COMPOSITIONS FOR OBJECTIVELY CHARACTERIZING MEDICAL IMAGES

Methods and compositions are provided for objectively characterizing a pathological lesion in a patient. The method comprises: introducing into the patient a contrast enhancing agent; subjecting the patient to at least one of magnetic resonance imaging and computed tomography to obtain an image; and applying a 3-D autocorrelation function to a subdomain of interest of the image to obtain at least one 3-D autocorrelation spectrum. The method may further comprise comparing the at least one 3-D autocorrelation spectrum to a pre-existing 3-D autocorrelation spectrum that is characteristic for the pathological lesion. In one example, the methods and compositions may be useful for identifying and objectively characterizing amyloid plaque deposits characteristic of Alzheimer's Disease. 1. A method for characterizing a pathological lesion in a patient , the method comprising:introducing into the patient a contrast enhancing agent;subjecting the patient to at least one of MRI and CT to obtain an image; andapplying a 3-D autocorrelation function to a subdomain of interest of the image to obtain at least one 3-D autocorrelation spectrum.2. The method of claim 1 , further comprising comparing the at least one 3-D autocorrelation spectrum to a pre-existing 3-D autocorrelation spectrum that is characteristic for the pathological lesion.3. The method of claim 1 , wherein the subjecting comprises subjecting the patient to MRI.4. The method of claim 3 , wherein the contrast enhancing agent comprises: a phospholipid;', 'a phospholipid that is derivatized with a polymer; and', 'cholesterol,', 'wherein the liposomes at least one of encapsulate and chelate gadolinium compounds., 'liposomes, the liposomes comprising5. The method of claim 3 , wherein the contrast enhancing agent comprises: DPPC;', 'Gd-DTPA-BSA;', 'cholesterol; and', 'mPEG2000-DSPE., 'liposomes, the liposomes comprising6. The method of claim 3 , wherein the contrast enhancing agent comprises a GdDTPA chelate derivative ...

Multi-modality compact bore imaging system

A multi-modality imaging system ( 100 ) includes a gantry ( 101 ), including at least first and second imaging modalities ( 102, 104 ) respectively having first and second bores ( 113, 112 ) arranged with respect to each other along a z-axis, and a subject support ( 108 ) that supports a subject for scanning. The gantry is configured to alternately move to a first position at which the subject support extends into the first bore of first imaging modality for scanning an extremity of the subject and to a second position at which the subject support extends into the second bore of second imaging modality for scanning the extremity of the subject.

METHODS AND COMPOUNDS FOR THE DIAGNOSIS AND TREATMENT OF CANCER

The present invention provides for methods for use in the diagnosis and prognosis of cancer. The invention further provides to binding agents and kits for us e.g., in such methods. The present invention further relates to compositions, methods of making said compositions and methods of using the same, including use in the treatment and diagnosis of cancer, including lung, lymphoma, liver, thyroid and bladder cancer. Compositions of the present invention useful in the treatment of cancer include anti-sense and small inhibitory RNAs (siRNA). 2. The method of claim 1 , wherein said cancer is selected from lung claim 1 , lymphoma claim 1 , kidney claim 1 , breast claim 1 , liver claim 1 , bladder and thyroid cancer.36.-. (canceled)76. The method of claim 1 , wherein said cancer is non-small cell lung cancer (NSCLC).8. The method of claim 2 , wherein said lung cancer is small cell lung cancer (SCLC).917.-. (canceled)18. The method of claim 1 , wherein said method comprises the step of imaging the subject's lungs.19. The method of claim 18 , wherein said imaging further comprises the step of performing a chest X-ray claim 18 , computerized tomography (CT) scan claim 18 , magnetic resonance imaging (MRI) scan or positron emission tomography (PET) scan claim 18 , and wherein said imaging alone is insufficient for said diagnosing of cancer.2025.-. (canceled)26. The method of claim 1 , wherein said Ciz1 b-variant polypeptide comprises the amino acid sequence DEEEIEVRSRDIS (SEQ ID NO: 8).27. The method of claim 26 , wherein said Ciz1 b-variant polypeptide comprises the amino acid sequence of SEQ ID NO: 22.28. The method of claim 1 , wherein said biological sample is tissue claim 1 , blood claim 1 , plasma claim 1 , sputum claim 1 , bronchoalveolar lavage claim 1 , bronchoalveolar brushing or urine.2936.-. (canceled)37. The method of claim 1 , wherein said Ciz1 b-variant polypeptide is extracellular.3848.-. (canceled)49. The method of claim 1 , wherein said method further ...

Method and System for Differential Diagnosis of Chronic Schizophrenia and Chronic Alcoholism

Biomarker diagnosis of chronic schizophrenia in the presence of cognitive impairment is confirmed when Phosphocreatine (PCr) levels are increased, compared to normal levels, in both the left and right prefrontal cortices of the brain, with increased PCr specifically also in the left basal ganglia and also reduced NA/Crin the left superior temporal region of the brain. Biomarker differential diagnosis is also taught for chronic alcoholism (with or without cognitive impairment) and for chronic schizophrenia even when cognitive impairment is absent. 1. A method for the differential diagnosis of chronic schizophrenia or chronic alcoholism , comprising imaging the brain of a subject in need of diagnosis for the markers PCr , NA/Cr , and sPDE and determining any increase or decrease in the presence of said markers compared to normal levels in specified anatomic areas of the brain , and outputting the results of the imaging as one or more files or images to be viewed by a user.2. The method according to claim 1 , wherein after quantifying PCr claim 1 , NA/Crand sPDE claim 1 , a determination that (1) PCr levels are increased claim 1 , compared to normal levels claim 1 , in both the left and right prefrontal cortices of the brain claim 1 , together with increased (2) PCr specifically also in the left basal ganglia and also (3) reduced NA/Crin the left superior temporal region of the brain claim 1 , together confirm a differential diagnosis of chronic schizophrenia when cognitive impairment is present.3. The method according to claim 1 , wherein after quantifying PCr claim 1 , NA/Crand sPDE claim 1 , a determination that (1) phosphocreatine (PCr) levels are increased in the right basal ganglia claim 1 , with (2) reduced NA/Crin all three of: (a) the left basal ganglia; (b) the right occipital cortex; and (c) the left centrum semiovale claim 1 , together with (3) reduced sPDE in the right inferior parietal and the right centrum semiovale claim 1 , together confirm a ...

Method and system for modeling and processing fmri image data using a bag-of-words approach

Systems and methods for processing image data are provided. A computer implemented method for processing image data, comprises gathering 4-D image data from a subject, extracting time series data, and spatial and degree data of each voxel of the subject, deriving at least one feature from the time series data, deriving at least one feature from the spatial and degree data, combining the at least one feature from the time series data, and the at least one feature from the spatial and degree data to generate combined data, and inputting the combined data to a classifier, wherein the classifier outputs a classification based on the combined data.

METHODS FOR PHYSIOLOGICAL MONITORING, TRAINING, EXERCISE AND REGULATION

A computer assisted method for treating pain in a subject comprising measuring activity of one or more internal voxels of a brain of said subject associated with pain; communicating instructions to said subject which modulate activity of said voxel; and training said subject to control said internal voxel. 1. A computer assisted method for treating pain in a subject comprising:measuring activity of one or more internal voxels of a brain of said subject associated with pain;communicating instructions to said subject which modulate activity of said voxel; andtraining said subject to control said internal voxel.2. A method according to wherein measuring brain activity is performed by fMRI.3. A method according to wherein the determinations are made in less than 10 seconds relative to when the activity is measured.4. A method according to wherein the determinations are made in less than 1 second relative to when the activity is measured.5. A method according to wherein the determinations are made in less than 0.5 second relative to when the activity is measured.6. A method according to wherein the information is determined while the instrument used for measurement remains positioned about the subject.7. A method according to wherein the activity measurements are made using an apparatus capable of taking measurements from one or more internal voxels without substantial contamination of the measurements by activity from regions intervening between the internal voxels being measured and where the measurement apparatus collects the data.8. A method according to wherein measurements are made from at least 100 separate internal voxels claim 1 , and these measurements are made at a rate of at least once every five seconds.9. A method according to wherein measurements are made from a set of separate internal voxels corresponding to a scan volume including the entire brain.10. A method according to wherein the size of the internal voxels have a total three dimensional volume of ...

METHOD FOR MYOCARDIAL SEGMENT WORK ANALYSIS

The invention relates to medical monitoring apparatuses, methods, and computer programs for determining power or work as a function of time for individual myocardial segments based on strain and pressure measurements. Compared to prior art determinations of determination of mechanical power or work for individual segments, the invention is advantageous as it provides such determination solely from a pressure measurement or estimate and a measurement of strain, preferably by echocardiography, such as speckle tracking ultrasound imaging. This allows a fast, easy and non-invasive determination with high temporal and spatial resolution. A number of indices for segment work can be calculated which can be used as markers for the individual segment function as well as for a selection of patient for CRT. 1. An apparatus for receiving preparing and presenting data related to individual myocardial segment work from tissue strain imaging data , the apparatus comprising:a medical imaging device for non-invasively recording tissue strain imaging data for two or more myocardial segments; and 'calculating mechanical power, P(t), and/or mechanical work, W(t), traces for two or more individual myocardial segments as a function of time for a period comprising the time interval from the beginning of isovolumetric contraction and until the end of isovolumetric relaxation from ventricular tissue strain traces for each of the two or more myocardial segments, and a non-invasively determined pressure trace proportional to a ventricular pressure and in temporal synchrony with the strain traces.', 'an electronic processor capable of215-. (canceled)17. The apparatus according to claim 16 , wherein the mechanical work for segment n claim 16 , W(t) claim 16 , is calculated as:{'br': None, 'i': W', 't', 'P', 't', 'dt′+C, 'sub': n', '0', 'n', '2n, 'sup': 't', '()=∫(′)'}{'sub': '2n', 'wherein t′ is an integration variable and Cis a constant for segment n.'}18. The apparatus according to claim 1 , ...

DEFORMABLE REGISTRATION FOR TISSUE ANALYTICS

A tissue analysis system is disclosed. Tissue analysis systems include sensors that acquire signals originating from a target tissue and representative of a tissue property. A signal converter converts the signals to property measurements. An analysis engine can derive a variation of one tissue property with respect to another property and present the variation within a deformable registration imaging devices. 1. A tissue analysis system , comprising:at least one sensor configured to receive at least one signal representative of a first tissue property and a second tissue property of at least a portion of a target tissue;a signal converter coupled with the at least one sensor and configured to convert the at least one signal into a first property measurement of the first tissue property and a second property measurement of the second tissue property; anda deformable registration imaging device coupled with the signal converter and configured to present an image representative of a variation of the first tissue property relative to the second tissue property dependent on the first property measurement and the second property measurement.2. The system of claim 1 , wherein the at least one sensor comprises a sensor array.3. The system of claim 2 , wherein a first sensor receives a first signal representative of the first tissue property claim 2 , and a second different sensor receives a second signal representative of the second tissue property.4. The system of claim 1 , wherein the second property measurement comprises an observation time.5. The system of claim 4 , wherein the variation comprises a time derivative of the first tissue property with respect to the observation time.6. The system of claim 5 , wherein the time derivative comprises a velocity of the portion of the tissue.7. The system of claim 5 , wherein the time derivative comprises an acceleration of the portion of the tissue.8. The system of claim 5 , wherein the time derivative comprises a higher order ...

SYSTEM AND METHOD FOR CARDIOVASCULAR EXERCISE STRESS MRI

A system and method for cardiovascular exercise stress magnetic resonance using a MR-compatible treadmill. The treadmill is made of non-ferromagnetic materials and has a belt driven by a motor that produces rotational motion from pressurized fluid that is produced by a pump located outside the scan room. The treadmill is adjacent to the MR imager. Patients complete an exercise protocol on the treadmill and are then transferred to the MR imager without leaving the scan room. Images are acquired as quickly as possible post-exercise to more accurately diagnose cardiovascular disease in patients. 125-. (canceled)26. A treadmill system for use with an MR imager located in a scan room , comprising:a treadmill located in the scan room, the treadmill having a belt driven by a motor that produces rotational motion from pressurized fluid; anda pump located outside the scan room, the pump producing pressurized fluid and being operatively connected to the motor.27. The system of claim 26 , wherein the fluid is hydraulic fluid.28. The system of claim 27 , wherein the fluid is water-based.29. The system of claim 26 , wherein the treadmill is entirely made of non-ferromagnetic materials.30. The system of claim 26 , wherein an equipment room is located outside the scan room and the pump is located in the equipment room.31. The system of claim 26 , wherein the treadmill includes a lift cylinder that varies the gradient of the treadmill belt.32. The system of wherein the lift cylinder operates using pressurized fluid.33. The system of claim 26 , wherein the treadmill further includes a motor brake that limits the speed of the treadmill by constricting the flow of fluid and thereby subjecting the motor to back pressure.34. A method of conducting an MR study on a patient in a scan room that contains an MR imager and a treadmill that is adjacent the MR imager claim 26 , that has a belt claim 26 , and that has a motor that drives the belt by producing rotational motion from pressurized ...

Method and System for Diagnosis of Attention Deficit Hyperactivity Disorder from Magnetic Resonance Images

A method and system for automated diagnosis of attention deficit hyperactivity disorder (ADHD) from magnetic resonance images is disclosed. Anatomical features are extracted from a structural magnetic resonance image (MRI) of a patient. Functional features are extracted from a resting-state functional MRI (rsFMRI) series of the patient. An ADHD diagnosis for the patient is determined based on the anatomical features, the functional features, and phenotypic features of the patient using a trained classifier. An ADHD subtype may then be determined for patients diagnosed as ADHD positive using a second trained classifier. 1. A method for automated diagnosis of attention deficit hyperactivity disorder (ADHD) , comprising:extracting anatomical features from a structural magnetic resonance image (MRI) of a patient;extracting functional features from a resting-state functional MRI (rsFMRI) series of the patient; anddetermining an ADHD diagnosis for the patient based on the anatomical features, the functional features, and phenotypic features of the patient using a trained classifier.2. The method of claim 1 , wherein the structural MRI is a T-1 weighted MRI.3. The method of claim 1 , wherein the functional MRI series is a T2-weighted MRI series.4. The method of claim 1 , where the phenotypic features of the patient include age and gender of the patient.5. The method of claim 4 , wherein the phenotypic features of the patient further include handedness claim 4 , verbal IQ claim 4 , and performance IQ of the patient.6. The method of claim 1 , wherein extracting anatomical features from a structural magnetic resonance image (MRI) of a patient comprises:segmenting cortical hemisphere surfaces in the structural MRI; andextracting at least one anatomical feature at each of a plurality of uniformly spaced vertices on each of the cortical hemisphere surfaces.7. The method of claim 6 , wherein extracting at least one anatomical feature at each of a plurality of uniformly spaced ...

Functional integration of virtual prosthesis in a tissue model

Systems and methods of integrating a virtual prosthesis with a tissue model are presented. Tissue characteristics and prosthesis characteristics can be leveraged to construct observable tissue models that present a model of mutual deformation, especially a time-varying mutual deformation, of a tissue and a possible prosthesis. The mutual deformation indicates how the tissue and prosthesis impact each other over time, possibly on a voxel-by-voxel basis based on deformable registration techniques.

METHOD OF PROCESSING THORACIC REFLECTED RADIO INTERROGATION SIGNALS

A method of evaluating or monitoring the medical state of a human subject on the subject includes the steps of: positioning an antenna side of a self-contained radio apparatus for non-invasive, thoracic radio interrogation of a human subject proximally to the heart of the human subject; providing a radio frequency interrogation interference signal from the human subject, the radio frequency interrogation interference signal being low frequency components of reflections of a radio interrogation signal transmitted into the thorax of the subject; and determining with the apparatus on the subject at least at least one stroke volume value of the subject from radio frequency interrogation interference signal generated by the apparatus. 1. A method of electronically evaluating medical state of a human subject in near real time on the subject comprising the steps of:positioning an antenna side of a self-contained radio apparatus for non-invasive, thoracic radio interrogation of a human subject proximally to the heart of the human subject outside the human subject, the apparatus including a radio transmitter operably connected to the antenna and configured to transmit only an unmodulated radio frequency interrogation signal of a predetermined, fixed frequency through the antenna and into the proximally positioned human subject; a radio receiver operably connected to the antenna and configured to capture through the antenna reflections of the radio frequency interrogation signal returned from the human subject; processing circuitry including an electronic processor coupled with the radio receiver and a battery power source powering the apparatus;providing a radio frequency interrogation interference signal from the human subject and the radio receiver to the processing circuitry of the apparatus, the radio frequency interrogation interference signal being low frequency components of reflections of a radio interrogation signal transmitted into the thorax of the human subject ...

TIME VARYING DENSITY OF TISSUES

Systems for providing time varying density signatures of tissues are presented. The time varying density signatures can be calculated based on obtained sensor data reflecting one or more properties (e.g., physical, mechanical, electrical, etc.) of a target tissue. The time varying density signatures can then be used to generate an output where the output indicates how a target tissue's density changes with respect to time, possibly based on first, second, third, or higher order derivatives with respect to time. 1. A system for providing information about a tissue , comprising:a device that provides energy to the tissue;a sensor configured to receive a signal from that tissue that results at least in part from interaction of the energy with the tissue;a signal converter coupled with the sensor that converts the signal to a time varying density signature corresponding to a portion of the tissue; andan output device that produces an output dependent upon the density signature.2. The system of wherein the device is selected from the group consisting of a Magnetic Resonance Imaging (MRI) machine claim 1 , a computerized tomography (CT) machine claim 1 , an ultrasound machine claim 1 , nuclear imaging (e.g. claim 1 , positron emission tomography (PET) claim 1 , single photon emission computer tomography (SPECT) claim 1 , molecular imaging claim 1 , and an x-ray machine.3. The system of wherein the sensor is disposed distally from the tissue.4. The system of wherein the sensor is physically touching the tissue.5. The system of wherein the sensor is configured to selectively receive the signal from the tissue.6. The system of claim 5 , wherein the sensor is configured to selectively receive the signal from an anatomical structure comprising the tissue.7. The system of claim 6 , wherein the anatomical structure is a lung.8. The system of claim 6 , wherein the anatomical structure comprises a fractal property.9. The system of claim 1 , wherein the output device comprises a ...

APPARATUS AND METHOD FOR GENERATING MECHANICAL WAVES INTO LIVING BODIES, SYSTEM AND METHOD FOR MAPPING AN ORGAN OR TISSUE AND SYSTEM AND METHOD FOR CHARACTERISING THE MECHANICAL PROPERTIES OF SAID ORGAN OR TISSUE

A method and apparatus () for vibrating an organ and/or tissue and/or region of a subject's body () without a mechanical transmission to characterize at least one mechanical property of the region and/or tissue and/or organ, the apparatus () includes: elements (-) for generating a pressure wave of a given frequency in a gaseous medium, and waveguide elements () for guiding, in a gaseous medium, the pressure wave from the generating elements (-) to a human or animal body (). Wave guiding in the airways of a human or animal body and tissue displacement mapping, anisotropy, and mechanical property characterizing systems () and methods are also described. 117-. (canceled)18100202. Apparatus () for inducing a mechanical wave in at least one region of the body and/or organ and/or tissue of a human or animal subject () , said apparatus comprising:{'b': '102', 'means () for generating a pressure wave of a given frequency in a gaseous medium, and'}{'b': 104', '202', '3', '102', '202, 'waveguide means () in the form of a transmission tube for guiding, in air or any other gas mixture that may be used to ventilate the human or animal subject () (claim ), said pressure wave from said generating means () to a human or animal body ()'}{'b': 106', '108', '104', '108', '104, "an adaptation hose () arranged on the extremity () of the waveguide () at the human or animal body's side, for adapting this extremity () of the waiveguide () to a surface or a cavity of said body."}19100. The apparatus () according to claim 18 , characterized in that the gaseous medium includes labeled gas for medical imaging claim 18 , like helium-3 or sulfur hexafluoride for MRI.20100. The apparatus () according to claim 18 , characterized in that the means for generating a pressure wave comprise:{'b': '118', 'a loudspeaker (),'}an electromechanical vibrator, ora piezoelectric element.21100104. The apparatus () according to claim 18 , characterized in that the waveguide in the form of a transmission tube is ...

SYSTEMS AND METHODS FOR SIDESSTREAM DARK FIELD IMAGING

The present application discloses systems and methods for the comprehensive monitoring of the microcirculation in order to assess the ultimate efficacy of the cardiovascular system in delivering adequate amounts of oxygen to the organ cells. In some cases, system embodiments may utilize reflectance avoidance by reflectance filtering, such as OPS imaging or Mainstream Dark Field imaging, or by Sidestream Dark Field imaging, which utilizes external direct light on the tip of the light guide to achieve reflectance avoidance whereby incident and reflected light do not travel down the same pathway. 1. A handheld system for sidestream dark field analysis of tissue beneath a tissue surface , comprising:an elongate body portion including an imaging passage extending along a length of the elongate body portion;one or more illumination passages which are disposed radially about the imaging passage within the elongate body portion and which are optically isolated from the imaging passage along an entire length of the imaging passage for surface reflection avoidance or reduction when an examination tip of the elongate body portion is proximate the tissue surface;a plurality of light sources which are disposed in optical communication with the one or more illumination passages and which are configured to project light onto a first tissue site via the one or more illumination passages; andan analysis section optically coupled to the imaging passage and configured to capture data of tissue beneath the tissue surface from a second tissue site different from and adjacent to the first tissue site.2. The system of further comprising at least one isolation surface which is configured to optically isolate an illumination field of the first tissue site from an imaging field of the second tissue site.3. The system of further comprising a disposable detachable cap disposed over a distal portion of the elongate body portion having a distal window configured to allow illumination and imaging ...

METHODS FOR MEASUREMENT AND ANALYSIS OF BRAIN ACTIVITY

A computer assisted method is provided for diagnosing the in condition of a subject associated with particular activation in one or more regions of interest, the method comprising: having the subject perform a behavior or have a perception adapted to selectively activate one or more regions of interest associated with the condition; measuring activity of the one or more regions of interest as the behavior is performed or the subject has the perception; diagnosing the condition associated with the one or more regions of interest based on the activity in response to the behavior or perception; performing an intervention; and repeating this process one or more times including repeating said behavior, said measuring of activity and said diagnosis at a later time; and observing changes between measurements that are associated with said intervention. 1. A computer assisted method is provided for diagnosing a condition of a subject wherein said condition is associated with an activation in one or more regions of interest , said method comprising:having said subject perform a behavior or have a perception adapted to selectively activate said one or more regions of interest associated with said condition;measuring activity of said one or more regions of interest as said behavior is being performed or said subject has the perception;diagnosing said condition associated with said one or more regions of interest based on said activity in response to the behavior or perception;performing an intervention; andrepeating this process one or more times at a later time and observing changes between measurements before and after said intervention.2. A method according to wherein said measuring activity is preformed by fMRI.3. A method according to wherein the measuring activity is made in less than 10 seconds relative to when the activity is measured.4. A method according to wherein said intervention comprises an application of a pharmacological agent.5. A method according to wherein ...

SYSTEM AND METHODS FOR ASSESSING HEART FUNCTION

Systems and methods can be used to provide an indication of heart function, such as an indication of mechanical function or hemodynamics of the heart, based on electrical data. For example, a method for assessing a function of the heart can include determining a time-based electrical characteristic for a plurality of points distributed across a spatial region of the heart. The plurality of points can be grouped into at least two subsets of points based on at least one of a spatial location for the plurality of points or the time-based electrical characteristics for the plurality of points. An indication of synchrony for the heart can be quantified based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points. 1. A method for assessing a function of a patient's heart , comprising:determining a time-based electrical characteristic for a plurality of points corresponding to at least one spatial region of the heart;grouping the plurality of points into at least two subsets of points based on at least one of a spatial location for each of the plurality of points or the time-based electrical characteristic for each of the plurality of points; andquantifying an indication of synchrony for the heart based on relative analysis of the determined time-based electrical characteristic for each of the at least two subsets of points.2. The method of claim 1 , wherein the at least two subsets of points correspond to different chambers of the heart claim 1 , the method further comprising computing an index having at least one value representing synchrony between the different chambers.3. The method of claim 2 , wherein the different chambers of the heart comprise the left ventricle and the right ventricle.4. The method of claim 2 , wherein the quantifying further comprises:computing a first statistical parameter for each of the plurality of points associated with a first chamber of the heart,computing a second ...

System for providing targeted electrical stimulation to tissue

Provided is a system that may be used in delivering targeted electrical stimulation to tissue, such as animal bodily tissue. A system according to the present invention includes a longitudinal stimulation probe that includes a first electrode disposed at a distal tip and a second electrically conductive surface spaced proximally from the first electrode. Another system according to the present invention may include an improved user interface including an improved probe/handle interface including high visibility indication.

SYSTEM, METHOD AND FACILITY FOR REDUCING PEDIATRIC PATIENT ANXIETY DURING MEDICAL DIAGNOSTIC IMAGING PROCEDURES

A facility for performing a medical examination includes a room, a medical imaging system located in the room, and a plurality of elements installed on at least one of the room and the medical imaging system, the elements collectively creating a first theme that forms a physical environment at least partially surrounding a patient, wherein the theme is presented in a manner to reduce the level of patient anxiety and fear experienced by the patient being imaged. A medical imaging system is also described. A method of imaging a patient using the facility, a method of remodeling an existing facility, and a method of determining a theme to be used in a medical facility are also described. 1. A medical imaging facility comprising:a medical imaging unit positioned in an imaging room;an imaging table adapted to move a medical patient with respect to the medical imaging unit; anda plurality of thematic elements installed on the medical imaging unit and the table, the plurality of thematic elements collectively creating a theme that forms a physical environment at least partially surrounding a patient, wherein the theme is presented in a manner to reduce the level of patient anxiety and fear experienced by the patient being imaged;wherein the theme includes an audible component, the audible component utilizing an inherent sound of the medical imaging unit is incorporated therein.2. The medical imaging facility of comprising an audio system positioned within the imaging room and configured to transmit sounds related to the theme that cooperate with the actual sound of the equipment.3. The medical imaging facility of wherein the audio system is configured to enhance the theme by cooperating with the sound of the equipment to resemble one of a roar of a waterfall and a rocket.4. The medical imaging facility of wherein the plurality of thematic elements is partially comprised of a plurality of thematic appliqués and a thematic painted on scheme cooperatively configured to ...

REPRESENTATION OF BLOOD VESSELS AND TISSUE IN THE HEART

A method for representation of blood vessels and/or tissue in a heart of a human or animal body is described, with an imaging method and an assignment method, which allows the assignment to a heart phase of time-resolved images acquired with the imaging method. A mask series with a series of temporally-resolved first images of the heart is acquired, wherein the first images are assigned to a heart phase by the assignment method. A filling series with a series of temporally-resolved second images of the heart is acquired, wherein the second images are assigned to a heart phase by the assignment method. The first and second images assigned to the same heart phase are computed for creating a series of phase-selective subtraction images. The phase-selective subtraction images and/or the second images are computed, taking into account the heart movement for creating temporally and/or spatially-resolved perfusion data of the heart. 1. A method for representing blood vessels and/or tissue of a heart of a human or animal body with an imaging method and an assignment method , which allows assignment of time-resolved images acquired with the imaging method to a heart phase , wherein blood in the blood vessels and/or tissue has two states , wherein the blood in the first state does not comprise a contrast medium , and wherein the blood in the second state comprises a contrast medium , the method comprising:acquiring, by the imaging method, a mask series comprising temporally-resolved first images of the heart, wherein the blood is in the first state, and wherein the first images are assigned to a heart phase by the assignment method;acquiring, by the imaging method, a filling series comprising temporally-resolved second images of the heart, wherein the blood is in the second state and wherein the second images are assigned to the heart phase by the assignment method;computing the first and second temporally-resolved images assigned to the heart phase for creating phase- ...

METHOD AND MAGNETIC RESONANCE SYSTEM FOR FUNCTIONAL MR IMAGING OF A PREDETERMINED VOLUME SEGMENT OF THE BRAIN OF A LIVING EXAMINATION SUBJECT

In a method and a magnetic resonance (MR) system for functional MR imaging of a predetermined volume segment of the brain of a living examination subject, MR data of the predetermined volume segment are acquired, EEG data of the examination subject are acquired with the acquisition of the EEG data taking place simultaneously with the acquisition of the MR data, and the MR data automatically evaluated dependent on the acquired EEG data. 1. A method for functional magnetic resonance (MR) imaging of a predetermined volume segment of the brain of a living examination subject , comprising:operating a magnetic resonance data acquisition unit to acquire MR data from a predetermined volume segment of the brain of a living examination subject;simultaneously with acquisition of said MR data, acquiring EEG data from the examination subject; andproviding said MR data and said EEG data to a computerized processor and, in said processor, automatically evaluating said MR data dependent on said EEG data in order to produce an evaluation result indicative of brain activity of the examination subject, and making said evaluation result available in electronic form at an output of said processor.2. A method as claimed in comprising:in said processor, implementing a spectral analysis of said EEG data; andevaluating said MR data dependent on said spectral analysis.3. A method as claimed in comprising acquiring said MR data and said EEG data simultaneously in multiple claim 1 , successive time slices;in said processor, for each of said time slices, automatically determining a frequency spectrum of the EEG data acquired during the respective time slice, and determining a class for the respective time slice dependent on the frequency spectrum determined for the respective time slice;in said processor, associating MR data acquired during the respective time slice with the class determined for the respective time slice; andin said processor, evaluating MR data of a predetermined class ...

METHOD AND APPARATUS FOR NONINVASIVE QUANTITATIVE DETECTION OF FIBROSIS IN THE HEART

Embodiments provide a noninvasive quantitative method for detecting extent and/or types of fibrosis in the heart. In embodiments, information pertaining to the extent and/or types of fibrosis may aid in the diagnosis of specific cardiac diseases and heart failure and/or may assist in determining suitable treatment options. Embodiments provide methods and apparatuses for determining the extent of fibrosis in viable and nonviable myocardium, which may then be correlated to heart disease and failure. Thus, in an embodiment, a method of screening individuals for the purpose of heart disease or heart failure prevention may be provided using the detection methodology described herein. 1. A method of detecting fibrosis in heart tissue , comprising:selecting a sample of viable or nonviable heart tissue;contacting the sample with an extracellular contrast agent;obtaining with a magnetic resonance imaging device one or more measurements of the contrast uptake of the sample to determine an extent of expansion of extracellular volume in the sample as an indicator of diffuse interstitial and/or replacement fibrosis, wherein obtaining one or more images using magnetic resonance imaging comprises obtaining a plurality of measurements in blood and in the sample, both before and after contact with one or more contrast agents to determine the tissue sample partition coefficient for the extracellular contrast agent.2. The method of claim 1 , wherein contacting the sample with an extracellular contrast agent comprises contacting the sample with a Gadolinium-containing contrast agent.3. The method of claim 1 , wherein contacting the sample with an extracellular contrast agent comprises contacting the sample with gadodiamide.4. The method of claim 1 , wherein contacting the sample with an extracellular contrast agent comprises contacting the sample with an extracellular collagen-binding contrast agent.5. The method of claim 1 , wherein contacting the sample with an extracellular contrast ...

Automatic quantification of asymmetry

An apparatus detects asymmetry in an object, such as a brain. The apparatus includes a processor programmed to fit a three-dimensional image of the object to a preselected shape, such as a standard brain atlas. The processor projects the three-dimensional image of the object to a two-dimensional surface image. The processor compares corresponding mirror image symmetric voxel pairs on the left and right sides of the surface image. The processor generates at least one of an asymmetry map and an asymmetry index based on the deviations in the pixel pairs. The processor can also mask, before the comparison, pixels of the surface image which are asymmetric in a normal brain.

Method and System for 4D Radiological Intervention Guidance (4D-cath)

An imaging method for radiologically guiding an instrument during medical interventions on an object comprising: 1. An imaging method for radiologically guiding an instrument during medical interventions on an object , the method comprising:a) providing a first image of said object followed byb) providing updated images on-the-fly during the intervention to an operator by measuring an undersampled set of projections of said object and reconstructing said updated image based on changes between said first image or an update of said first image and said undersampled set of projections.2. Method according to claim 1 , wherein said imaging method is based on ionizing radiation and the undersampled set of projections is measured with a minimized radiation dose.3. Method according to claim 1 , wherein said first image claim 1 , said update of said first image and said updated images comprise volumetric images of the object.4. Method according to claim 1 , wherein said first image comprises a high-resolution volumetric image of the object claim 1 , which is acquired prior to the intervention claim 1 , optionally based on a fully sampled set of projections claim 1 , or which is provided from a database.5. Method according to claim 1 , wherein said update of said first image encompasses said first image and at least parts of one or more updated images reconstructed in previous runs during the intervention.6. Method according to claim 1 , wherein said update of said first image is a sliding prior defragmenting updated image of previous runs.7. Method according to claim 1 , wherein said undersampled sets of projections measured on-the-fly are stored for a delayed reconstruction of soft tissue contrast.8. Method according to claim 1 , wherein the amount of said changes is determined by forward projecting said first image or said update of the first image according to the projections comprised in the undersampled set of projections giving a set of equivalent projections based on ...

Systems and Methods for Deformation Compensation Using Shape Sensing

A method and medical system for estimating the deformation of an anatomic structure that comprises generating a first model of at least one anatomical passageway from anatomical data describing a patient anatomy and determining a shape of a device positioned within the branched anatomical passageways. The method and medical system also comprise generating a second model of the plurality of branched anatomical passageways by adjusting the first model relative to the determined shape of the device. 1. A method for estimating the deformation of an anatomic structure comprising:generating a first model of at least one anatomical passageway from anatomical data describing a patient anatomy;determining a shape of a device positioned within the branched anatomical passageways; andgenerating a second model of the plurality of branched anatomical passageways by adjusting the first model relative to the determined shape of the device.2. The method of wherein determining a shape of the device includes receiving information from an optical fiber shape sensor.3. The method of wherein determining a shape of the device includes receiving information from an electromagnetic sensor.4. The method of further comprising fitting a sampling of points along the shape of the device to the first model.5. The method of further comprising computing a set of deformation forces and wherein generating a second model further includes adjusting the first model in response to the set of deformation forces.6. The method of further comprising computing a set of restorative forces and wherein generating a second model further includes adjusting the first model in response to the set of restorative forces.7. The method of further comprising computing a set of maintenance forces and wherein generating a second model further includes adjusting the first model in response to the set of maintenance forces.8. The method of further comprising creating a weighted sum of a set of deformation claim 1 , ...

Integration of MRI into Radiation Therapy Treatment

Apparatus for radiation therapy combines a patient table, an MRI and a radiation treatment apparatus mounted in a common treatment room with the MR magnet movable from a position outside a radiation shielded door to an imaging position. An RF-shielded door is movable between a position, separating part of the treatment apparatus from the magnet and an open position allowing access of the patient to the treatment apparatus. In one configuration there is a row of treatment rooms and the magnet is mounted to move along a passageway outside the row of radiation shielded doors of the rooms. 1. Apparatus for radiation therapy of a patient comprising:a patient support table;a patient support table;a magnetic resonance imaging system for acquiring MR images of an imaging volume including the target location of the patient; an MR magnet operable to generate a magnetic field to be applied to the patient, the magnet having a cylindrical bore for surrounding the target location of the patient;', 'an RF transmit coil arrangement for generating an RF pulse in a transmit stage to be applied to the subject to be imaged such that the subject generates an MR signal in response to the magnetic field and the RF pulse applied;', 'a receive coil arrangement for acquiring the MR signal in a receive stage;', 'and a signal processing system for receiving the MR signal for carrying out signal processing by which an image is generated;, 'the imaging system includinga treatment apparatus for applying a radiation therapy to a target location in the patient on the support table;the patient support table and the treatment apparatus being mounted in a treatment room which is radiation shielded and has an opening which includes a radiation shielded door arrangement operable to close the opening;the MR magnet being mounted for movement from a position exterior of the radiation shielded door arrangement into the opening to an imaging position for cooperation with the patient on the patient support ...

Cardiac mri curvilinear tagging

A preparation sequencing system and methods are disclosed for generating curvilinear taglines of altered magnetization in an imaging plane of an NMR image. A preparation sequencing module is disclosed for generating a sinusoidal gradient signal simultaneously with a continuous a radio frequency (RF) signal, wherein the sinusoidal gradient signal is shaped to generate a rotating on-resonance excitation plane such that each point in the imaged target volume is on-resonance at least once in a period corresponding to one full rotation of the excitation plane. The on-resonance excitation plane is configured to simultaneously generate a plurality of curvilinear or circular taglines of altered magnetization in the imaging plane.

Automatic reduction of interfering elements from an image stream of a moving organ

Apparatus and methods are described for imaging a portion of a body of a subject that undergoes a motion cycle. A plurality of image frames of the portion are acquired. The image frames are enhanced with respect to a first given feature of the image frames, by (a) image tracking the image frames with respect to the first given feature, (b) identifying a second given feature in each of the image frames, and (c) in response to the identifying, reducing visibility of the second given feature in the image frames. The image frames that (a) have been image tracked with respect to the first given feature, and (b) have had reduced therein the visibility of the second given feature, are displayed as a stream of image frames. Other embodiments are also described.

NEURONAVIGATION-GUIDED FOCUSED ULTRASOUND SYSTEM AND METHOD THEREOF

The present invention discloses a neuronavigation-guided focused ultrasound system and a method for the same, which are used to guide focused ultrasound energy to a target point. The system of the present invention comprises a focused ultrasound device, a neuronavigation system and a fixture. According to an image of an interested region of an individual, a focus point of the focused ultrasound device, and tracking points provided by the neuronavigation system, the neuronavigation system performs a calibration process and establishes a positional relationship between the focus point and the image of the interested region. Thereby, the neuronavigation system can recognize the focus point and guide focused ultrasound to the target point. 1. A neuronavigation-guided focused ultrasound system , which guides a focused ultrasound energy to a target point , comprisinga focused ultrasound device generating a focus point and delivering said energy to said target point;a neuronavigation system electrically connecting with said focused ultrasound device and including a calibration unit, wherein said calibration unit establishes a positional relationship between said focus point and an image of a interested region of an individual, performs a calibration process on coordinates, and enables said neuronavigation system to recognize said focus point and define said target point; anda fixture fixing said interested region of said individual.2. The neuronavigation-guided focused ultrasound system according to claim 1 , wherein said focused ultrasound device further comprisesa signal generator generating an ultrasonic signal;a signal amplifier electrically connecting with said signal generator and amplifying said ultrasonic signal into said focused ultrasound; andan ultrasonic transducer electrically connecting with said signal amplifier, delivering said focused ultrasound to said target point, wherein a central frequency of said focused ultrasound resonates with said ultrasonic ...

Magneto-motive ultrasound detection of magnetic nanoparticles

Provided herein are systems, methods and compositions for the use of ultrasound for detection of cells and nanoparticles.

System for integrated wound analysis

A system for integrated wound analysis; said system including sensing and image recording elements; sensed data and images of at least a first recording session stored for analysis; said system including a reference system whereby sensing and image recording of any subsequent said recording session substantially repeats sensing and recording of parameters of said first recording session.

Image-Assisted Diagnostic Evaluation

Disclosed herein is a framework for facilitating image-assisted diagnostic evaluation. In accordance with one aspect of the framework, imaging parameters used in acquiring a treatment image of a portion of patient anatomy are automatically recorded during an imaging examination. The treatment image may indicate at least one location of at least one treated site. During a follow-up examination, a follow-up image of the portion of the patient anatomy may be automatically acquired using the recorded imaging parameters. To assist evaluation of treatment results, the treatment image with the indicated location of the treated site may be overlaid over the follow-up image. 1. An imaging system for image-assisted diagnostic evaluation , comprising:an acquisition processor for automatically recording, during an imaging examination, imaging parameters used in acquiring a treatment image of a portion of patient anatomy, wherein the treatment image indicates at least one location of at least one treated site;a memory for storing the imaging parameters; andan image processor for using, during a follow-up examination, the recorded imaging parameters to acquire a follow-up image of the portion of the patient anatomy, and to assist evaluation of treatment results by overlaying the treatment image with the indicated location of the treated site over the follow-up image.2. The system according to claim 1 , wherein the imaging parameters comprise at least one C-arm angulation indicative parameter.3. The system according to claim 1 , wherein the imaging parameters comprise at least one patient support table position indicative parameter.4. The system according to claim 1 , wherein the image processor claim 1 , during the follow-up examination claim 1 , adjusts a C-arm and a patient support table according to the recorded imaging parameters to acquire the follow-up image.5. The system according to claim 1 , wherein the treated site comprises a stem cell injection site.6. The system ...

Holder set and brain function measuring device using same

This holder set is provided with: an optical bioinstrumentation holder which has at least two probe mounting units into which are inserted light-transmitting probes which irradiate light from the tip, or light-receiving probes which receive light from the tip, and which is mounted on the subject's head; and a electroencephalograph holder which has at least one electrode mounting unit into which an EEG electrode is inserted which detects the potential difference with a reference electrode. This optical bioinstrumentation holder is provided with a linear trunk unit extending in a first direction, and at least two linear branches extending in a second direction different from the first direction, and the electroencephalograph holder is provided with a linear trunk unit extending in a first direction, and at least one linear branch extending in the direction opposite to said second direction.

NON-INVASIVE METHODS AND SYSTEMS FOR PRODUCING CARDIAC ELECTROGRAM CHARACTERISTIC MAPS FOR USE WITH CATHETER ABLATION OF VENTRICULAR TACHYCARDIA

A non-invasive method of producing a three-dimensional cardiac electrogram characteristic map for use in catheter ablation of ventricular tachycardia includes receiving left ventricle three-dimensional image data of a patient's heart; segmenting a left ventricle image of the patient's heart based on the left ventricle three-dimensional image data into scar tissue, normal myocardium tissue and left ventricle cavity regions; determining scar tissue thickness and normal myocardium tissue thickness for a plurality of portions of the left ventricle image of the patient's heart; receiving predetermined data that associate a value of at least one electrogram characteristic to each scar tissue thickness and each normal myocardium tissue thickness for the plurality of portions of said left ventricle image of said patient's heart; and generating the three-dimensional cardiac electrogram characteristic map of the at least one electrogram characteristic corresponding to the left ventricle image of the patient's heart based on the predetermined data. 1. A non-invasive method of producing a three-dimensional cardiac electrogram characteristic map for use in catheter ablation of ventricular tachycardia , comprising:receiving left ventricle three-dimensional image data of a patient's heart;segmenting a left ventricle image of said patient's heart based on said left ventricle three-dimensional image data into scar tissue, normal myocardium tissue and left ventricle cavity regions;determining scar tissue thickness and normal myocardium tissue thickness for a plurality of portions of said left ventricle image of said patient's heart;receiving predetermined data that associate a value of at least one electrogram characteristic to each scar tissue thickness and each normal myocardium tissue thickness for said plurality of portions of said left ventricle image of said patient's heart; andgenerating said three-dimensional cardiac electrogram characteristic map of said at least one ...

SYSTEM AND METHODS FOR OPTICAL STIMULATION OF NEURAL TISSUES

The present invention, in one aspect, relates to a system for stimulating neural tissue of a living subject. The system comprises an energy source capable of generating optical energy, a connector having a first end and a second end capable of transmitting optical energy, and a probe operably coupled to the second end of the connector and having an end portion for delivering optical energy to a target neural tissue. In one embodiment, the energy source comprises a tunable laser. 133-. (canceled)34. A method of optically stimulating tissue of a living subject , comprising the step ofdelivering optical energy directly to a target tissue at a distance away from the target tissue for a predetermined time period such that the target tissue receives sufficient optical energy to initiate an electrical response within the target tissues, wherein the optical energy has a wavelength within a range from about 1.2 μm to about 10 μm;receiving, at a sensing electrode placed at the target tissue, an electrical signal of the electrical response; andrecording and processing, at a computing device, the electrical signal received from the sensing electrode.35. The method of claim 34 , further comprising the step of focusing the optical energy on the target tissue so that the target tissue propagates the electrical response.36. The method of claim 35 , wherein focusing the optical energy occurs in an area with a diameter in a range from 10 μm to 1000 μm.37. The method of claim 34 , wherein the optical energy is delivered in a motion to the target tissue.38. (canceled)39. The method of claim 34 , wherein the optical energy is generated by a tunable laser.40. The method of claim 34 , wherein the optical energy is generated by a pulsed infrared laser.41. (canceled)42. (canceled)43. The method of claim 40 , wherein the optical energy is delivered with a repetition rate no more than 1 claim 40 ,000 Hz.44. The method of claim 40 , wherein the optical energy comprises a laser beam with a ...

Method and apparatus for determining blood flow required, method and apparatus for producing blood flow image, and method and apparatus for processing myocardial perfusion image

A method of determining a required blood flow includes obtaining morphological information of a coronary artery in a cardiac image, segmenting the cardiac image into at least one myocardial region based on the morphological information of the coronary artery, and determining a blood flow required for each of the at least one myocardial region.

Device For Detecting and Illuminating Vasculature

A laser based vascular illumination system utilizing a FPGA for detecting vascular positions, processing an image of such vasculature positions, and projecting the image thereof onto the body of a patient.

Fiber optic systems for mri suites and related devices and methods

Fiber optic systems with an MR compatible mouse in an MR scanner room that connects to a fiber optic computer mouse interface that is attached to a fiber optic cable that connects to a USB port of a computer in the MR control room to allow the mouse in the MR scanner room to move a cursor on a monitor in communication with the computer in the control room of an MRI suite during an MRI guided surgical procedure. The fiber optic cable(s) can be routed though a conventional RF wall waveguide and avoids the need for additional holes in the penetration panel for connectors. The fiber optic systems can also include up converters and down converters for providing fiber optic video signals from cameras in the MR scanner room to display video signal on the monitor.

Enhanced fat saturation in myocardial infarction mri

MRI k-space data is acquired for a patient ROI during data acquisition sequences including a nuclear magnetic resonance (NMR) signal readout period using a late gadolinium enhanced (LGE) data acquisition sequence including at least one fat-specific RF NMR magnetization inversion pulse imposed (a) after a water-specific RF NMR magnetization inversion pulse timed to cause a substantial null in NMR magnetization of normal tissue protons near a center of the readout period and (b) before the readout period center, which fat-specific inversion pulse is also timed to cause a substantial null in NMR magnetization of fat tissue protons near the readout period center. The acquired MR image data is reconstructed into a contrast enhanced LGE image of tissues within the ROI but having substantially suppressed normal and fat components therein.

Analytic Morphomics: High Speed Medical Image Automated Analysis Method

A computer-implemented method is provided for anatomically indexing a subject. The method includes: receiving image scan data representing a volume of a subject, where the image scan data is comprised of a plurality of image slices of the subject and includes at least a portion of a vertebral column of the subject; identifying the vertebral canal of the vertebral column of the subject in the image scan data; determining a plurality of markers for the vertebral column, where each marker is indicative of a different vertebral body of the vertebral column and includes its location in the image scan data defined in a coordinate system, such that the plurality of markers define a vertebral level coordinate system; and storing each marker along with its location in a database. The markers can subsequently be used to reference other anatomical components of the subject across different image scans. 1. A computer-implemented method for anatomically indexing a subject , comprising:receiving, by an image processor, image scan data representing a volume of a subject, the image scan data being comprised of a plurality of image slices of the subject and including at least a portion of a vertebral column of the subject, the vertebral column having a vertebral canal and comprised of a plurality of vertebral bodies;identifying, by the image processor, the vertebral canal of the vertebral column of the subject in the image scan data; 'storing, by the image processor, each marker in the plurality of markers along with its location in a database, wherein the image processor is embodied as computer executable instructions executed by a computer processor.', 'determining, by the image processor, a plurality of markers for the vertebral column, each marker in the plurality of markers is indicative of a different vertebral body of the vertebral column and includes its location in the image scan data defined in a first coordinate system, such that the plurality of markers define a ...

System and method for quantifying or imaging pain using electrophysiological measurements

A method for computing a quantitative metric indicative of pain experienced by a subject using an electrophysiological signal detection system is provided. Electrophysiological data are acquired from a subject with the electrophysiological signal detection system. Modulations in the acquired electrophysiological data that are associated with pain experienced by the subject during the acquisition of the electrophysiological data are identified. A quantitative metric indicative of the pain experienced by the subject is computed by processing the identified modulations in the acquired electrophysiological data.