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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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05-01-2012 дата публикации

Biosensor coated with electroactive polymer layer demonstrating bending behavior

Номер: US20120004522A1

Автор: Jang-Hyun Youn, Seon-Jeong Kim, Sun Ill Kim

Принадлежит: Industry University Cooperation Foundation IUCF HYU

Disclosed is a biosensor coated with an electroactive polymer layer demonstrating a bending behavior, more specifically a biosensor including an electroactive polymer layer coated on the surface of a bioreceptor and an electrode connected to the electroactive polymer layer. When an electrical stimulation is applied to the electrode, the electroactive polymer layer shows a bending behavior and thus the surface of the bioreceptor can be exposed to an analyte to allow a concentration analysis of the analyte. When used as an implantable biosensor, the disclosed biosensor may have a substantially increased life span since the bioreceptor can be selectively exposed to the analyte.

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Номер записи: 1

12-01-2012 дата публикации

Method for distributing contact information between applications

Номер: US20120009902A2

Автор: Jon Peterson, Peter Davis, Webb Dryfoos

Принадлежит: Individual

A method and system for distributing contacting information between applications is provided. The system preferably uses an ENUM-type protocol and a middleware tool kit to associate telephone numbers to other identifying information, such as e-mail addresses or URLs for web sites. The system enables the associated contacting information to be shared across multiple applications that may be implemented on a computer or a mobile telephony device. Information is shared only after verification that a requester is authorized to receive the requested contacting information.

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Номер записи: 2

02-02-2012 дата публикации

System, method and apparatus for performing real-time virtual medical examinations

Номер: US20120029303A1

Автор: Fawzi Shaya

Принадлежит: Fawzi Shaya

Disclosed herein is a method for permitting a real-time virtual medical examination using a patient device and at least one diagnostic device including receiving, at the patient device, a signal transmitted from the at least one diagnostic device; generating diagnostic information based on the received signal; encrypting the diagnostic information; establishing communication over a network between the patient device and a first remote server; establishing a video conferencing session via a second remote server; and transmitting the encrypted diagnostic information to the first remote server.

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Номер записи: 3

16-02-2012 дата публикации

Devices and methods for respiratory variation monitoring by measurement of respiratory volumes, motion and variability

Номер: US20120041279A1

Автор: Alexander Mattfolk, Alexander Panasyuk, Anita Karcz, Arvil Nagpal, Charles Jahnke, James F. Toy, IV, Jenny E. Freeman, Michael Lalli, Nathaniel Steiger, Roman Bokhenik, Svetlana V. Panasyuk

Принадлежит: Respiratory Motion Inc

This invention is directed to devices and methods for assessing a patient. The devices have at least one impedance measuring element functionally connected to a programmable element, programmed to analyze an impedance measurement, and to provide an assessment of at least one respiratory parameter of the patient. Preferably the device includes electronics which aid in calibration, signal acquisition, conditioning, and filtering.

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Номер записи: 4

15-03-2012 дата публикации

Measuring Instrument for Determining the Tissue Alcohol Concentration

Номер: US20120062879A1

Автор: Hartmut Spennemann, Ulrich Kallmann

Принадлежит: ROBERT BOSCH GMBH

A measuring instrument for determining the concentration of components in the body tissue by reflection spectroscopy is disclosed. In order, inter alia, to increase the functional reliability in the case of vibrations, the measuring instrument includes a diode laser with at least one laser diode and a waveguide structure, which has an external resonator, with a wavelength selective element, for each laser diode. In the process, the radiation generated by a laser diode is coupleable into the waveguide structure and the corresponding resonator and once again decoupleable from the resonator and the waveguide structure. Moreover, a corresponding method and a motor vehicle equipped therewith are disclosed.

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Номер записи: 5

22-03-2012 дата публикации

Electrochemical sensors

Номер: US20120067724A1

Автор: Carolyn R. Kahn, Elicia Wong, Vern Norviel

Принадлежит: Sensor Innovations Inc

Described herein are substrates, sensors and systems related to measuring the concentration of an analyte such as hydrogen ion in a sample. Redox active moieties whose reduction and/or oxidation potentials are sensitive to the presence of an analyte are immobilized onto a surface of an electrode. Immobilized redox active moieties whose reduction and/or oxidation potential are insensitive to the analyte can be used for reference. Voltammetric measurements made using such modified surfaces can accurately determine the presence and/or concentrations of analytes in a sample of interest. The electrochemical sensors of the invention are robust and can be made so as not to require calibration or recalibration.

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Номер записи: 6

22-03-2012 дата публикации

System and method for physiological monitoring

Номер: US20120071731A1

Автор: Janell M. Gottesman

Принадлежит: Individual

Apparatus, systems, and methods for monitoring a sensor module mounted in a sensor platform, wherein the sensor platform includes an adhesive side and a pocket, wherein the pocket is designed to receive the sensor module, to facilitate sensing by the sensor module of physiological attributes, and to allow insertion and removal of the sensor device from the pocket.

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Номер записи: 7

29-03-2012 дата публикации

Apparatus And Methods For Wireless Communication Via Electrical Pulses Conducted By The Interstitial Tissues Of The Body For An Active Implantable Medical Device

Номер: US20120078322A1

Автор: Ashutosh Ghidiyal, Renzo Dal Molin

Принадлежит: SORIN CRM SAS

An active implantable medical device having wireless communication of data via electrical pulses conducted by the interstitial tissues of the body. This device ( 12, 14 ) includes a pair of electrodes ( 22, 24 ) and generates pulse trains consisting of a series of electrical pulses applied to the electrodes. The pulse train is modulated by digital information (data) that is produced by the device. A regulated current or voltage source ( 42 ) is used to generate ( 44, 48 ) current or voltage pulses to form the pulse train. Each current or voltage pulse is a biphasic pulse comprising a positive and negative alternation. The biphasic current or voltage modulated by the digital information, is injected between the electrodes ( 22, 24 ) and wirelessly communicated.

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Номер записи: 8

12-04-2012 дата публикации

Analyte Monitoring Devices and Methods

Номер: US20120088995A1

Автор: Benjamin Jay Feldman, Jean-Pierre Cole, Martin J. Fennell, Theodore John Kunich, Udo Hoss, Zenghe Liu

Принадлежит: Abbott Diabetes Care Inc

Methods and devices for providing application specific integrated circuit architecture for a two electrode analyte sensor or a three electrode analyte sensor are provided. Systems and kits employing the same are also provided.

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Номер записи: 9

10-05-2012 дата публикации

Remote medical device alarm

Номер: US20120112903A1

Автор: Richard A. Rattanni, Shane S. Volpe, Thomas E. Kaib

Принадлежит: Zoll Medical Corp

A remote alarm for use with a wearable medical device. The remote alarm is configured to receive alarms, voice messages and prompts issued by the wearable medical device and to repeat those alarms, voice messages and prompts in a manner that can more easily be perceived by a patient wearing the wearable medical device or a bystander. The remote alarm can be configured to receive a communication from the wearable medical device, and in response, to identify one or more messages to be provided to the patient or a bystander. The messages may be provided audibly, visually, tactilely or combinations thereof. The remote alarm may further be configured to take certain actions depending upon the content of the communication, such as sending a telephone message to alert emergency personnel to the identity, location and medical condition of the patient, or sending an email.

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Номер записи: 10

17-05-2012 дата публикации

Hospital bed with nurse call system interface unit

Номер: US20120119890A1

Автор: Carl W. Riley, Christopher A. Mathura, Irvin J. Vanderpohl, James Maurice Allen, Keith A. Huster, Patricia Anne Glidewell, Richard J. Schuman, Williams F. Collins, Jr.

Принадлежит: Individual

A system for use in a healthcare facility having a nurse call system with a nurse call computer located remotely from patient rooms is provided. The system includes a hospital bed having communication circuitry configured for communicating data from the hospital bed. An interface unit is spaced from the hospital bed. The interface unit has a first connector to which the hospital bed couples via a wired connection, a second connector which is communicatively coupled to the nurse call system, and circuitry comprising a third connector for connection to an external device.

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Номер записи: 11

07-06-2012 дата публикации

Movement Monitoring Device For Action Sports, And Associated Methods

Номер: US20120143514A1

Автор: Adrian F. Larkin, Burl W. Amsbury, Curtis A. Vock, Perry Youngs

Принадлежит: PhatRat Tech LLC

A movement monitoring device (MMD) for action sports has a detector for sensing motion associated with action sports, a processor for processing data from the detector to determine one or more movement metrics, and a communications port for wirelessly relaying the movement metrics to a remote location. A method collects motion data within action sports, including: detecting motion of a person or object engaged in action sports; determining one or more events associated with the motion; and wirelessly relaying the events to a remote network. One MMD for action sports is formed within a cell phone having a detector for sensing motion associated with action sports and a processor for processing data from the detector to determine one or more movement metrics for (a) display to a person using carrying the cell phone during action sports or (b) relaying the movement metrics to an external network for review by others.

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Номер записи: 12

14-06-2012 дата публикации

Physiological data acquisition utilizing vibrational identification

Номер: US20120146795A1

Автор: Gubbi Umesh Renukanand, Kenneth Margon

Принадлежит: Gubbi Umesh Renukanand, Kenneth Margon

The present invention utilizes an accelerometer (included within a wireless physiology monitoring device or as part of a separate device such as, but not limited to a smartphone, e.g., iPhone, or other mobile device) to link a patient with a separate medical data acquisition device such as a weight scale or a blood pressure monitor in order to collect and transmit a range of medical data associated with the user. The medical data acquisition device includes a vibration source for emitting a vibration at a predetermined or random frequency. When the acquisition device is activated, a vibration is transmitted from the through the patient and is detected by the accelerometer. The accelerometer then measures the particular frequency of vibration and transmits this information to a centralized monitoring unit (CMU). Based on the measured frequency, the CMU is able to know that the same patient wearing/holding the device is also the same patient using the data acquisition device. The vibration source may revolve through a number of predetermined frequencies (as determined on its own or instructed via the CMU) or simply generate a random frequency.

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Номер записи: 13

26-07-2012 дата публикации

System and method for endoluminal and translumenal therapy

Номер: US20120191079A1

Автор: David C. Lundmark, Farzad Soleimani, Frederic H. Moll

Принадлежит: Hansen Medical Inc

A system for conducting a denervation of the neural plexus adjacent the renal artery of a patient comprises a first elongate member operatively coupled to a testing element, a second elongate member having a distal portion coupled to an ablative element, and a controller configured to: activate an ablative element to selectively denervate a portion of the neural plexus which is positioned adjacent the ablative element; monitor a level of a compound in blood sampled from the testing element of the first elongate member; and modulate the activation of the ablative element based at least in part upon the level of renin monitored using the testing element.

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Номер записи: 14

02-08-2012 дата публикации

Apparatus and methods for monitoring physiological data during environmental interference

Номер: US20120197093A1

Автор: Eric Douglas Romesburg, Jesse Berkley Tucker, Joseph Norman Morris, Michael Edward Aumer, Steven Francis Leboeuf

Принадлежит: Individual

Apparatus and methods for attenuating environmental interference are described. A wearable monitoring apparatus includes a housing configured to be attached to the body of a subject and a sensor module that includes an energy emitter that directs energy at a target region of the subject, a detector that detects an energy response signal—or physiological condition—from the subject, a filter that removes time-varying environmental interference from the energy response signal, and at least one processor that controls operations of the energy emitter, detector, and filter.

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Номер записи: 15

13-09-2012 дата публикации

Bodily fluid composition analyzer with disposable cassette

Номер: US20120232362A1

Автор: James R. Braig, Jennifer H. Gable, Kenneth I. Li, Mark Wechsler, PENG Zheng, Richard Keenan

Принадлежит: Optiscan Biomedical Corp

Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

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Номер записи: 16

13-09-2012 дата публикации

Methods & systems to determine multi-parameter managed alarm hierarchy during patient monitoring

Номер: US20120232416A1

Автор: Jeffrey Jay Gilham, William Gregory Downs

Принадлежит: Spacelabs Healthcare LLC

The present specification discloses systems and methods of patient monitoring in which multiple sensors are used to detect physiological parameters and the data from those sensors are correlated to determine if an alarm should, or should not, be issued, thereby resulting in more precise alarms and fewer false alarms. Electrocardiogram readings can be combined with invasive blood pressure, non-invasive blood pressure, and/or pulse oximetry measurements to provide a more accurate picture of pulse activity and patient respiration. In addition, the monitoring system can also use an accelerometer or heart valve auscultation to further improve accuracy.

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Номер записи: 17

27-09-2012 дата публикации

Sensor Calibration

Номер: US20120240656A1

Автор: Barry Crane, Ian Francis, Robert Perkins, William Paterson

Принадлежит: Glysure Ltd

A sensor kit comprising a sensor for detecting an analyte, a sensor housing and a calibration chamber. The calibration chamber comprises a first compartment containing a first calibration solution and a second compartment containing a source of the analyte to be detected. A dividing material is located between the first and second compartments enabling them to be mixed on breakage or removal of the dividing material. Further compartment(s) containing further source(s) of the analyte may optionally be provided. Calibration can carried out by (a) taking a reading of the analyte concentration of the first calibration solution, (b) mixing the contents of the first and second compartments by breaking or removing the dividing material, and (c) taking a reading of the analyte concentration of the resulting mixture. Steps (b) and (c) can be repeated for further compartment(s) to provide further reading(s) if desired.

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Номер записи: 18

04-10-2012 дата публикации

Transdermal systems, devices, and methods for biological analysis

Номер: US20120252046A1

Автор: Jiangfeng Fei, Narasinha Parasnis, Swetha Chinnayelka

Принадлежит: Bayer HealthCare LLC

A transdermal test sensor includes a test chamber including a liquid, a reagent system in contact with the liquid, a housing containing the liquid, and a semipermeable membrane. The housing includes an opening, the semipermeable membrane is connected to the housing and covers the opening, and the housing and the semipermeable membrane enclose the liquid and the reagent system. The transdermal test sensor also includes an analyzer in communication with the liquid. When porated tissue is contacted with the semipermeable membrane and sufficient time is allowed for a fluid sample to traverse the porated tissue and for an analyte in the fluid sample to enter the liquid in the transdermal sensor through the semipermeable membrane, a change in at least one optical property or at least one electrical property of the liquid is detected. The change detected is then correlated with the analyte concentration in the fluid sample.

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Номер записи: 19

11-10-2012 дата публикации

Transdermal systems, devices, and methods to optically analyze an analyte

Номер: US20120258467A1

Автор: Paul Ripley, Swetha Chinnayelka

Принадлежит: Bayer HealthCare LLC

The invention provides transdermal optical analysis systems, test sensors, methods, and kits for determining the presence and/or concentration of at least one analyte in a fluid sample. The system includes a transdermal test sensor including an aqueous material including at least one analyte selective reagent and at least one optically active moiety. The optical system preferably uses fluorescent spectroscopy to correlate fluorescent emission or adsorption from a dye with the analyte concentration of the sample. An optical light source and/or detector may be housed with the aqueous material in a housing or external to the housing of the aqueous material.

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Номер записи: 20

11-10-2012 дата публикации

Ambulatory physiological monitoring with remote analysis

Номер: US20120259233A1

Автор: Eric K. Y. Chan, Harold Strandquist

Принадлежит: Individual

Applicants have disclosed a wireless method for remotely monitoring the physiological status of ambulatory patients by using at least one “cloud” server. Physiological data, including ECG data, is collected by a device worn by a patient and then wirelessly transmitted (e.g., via a cell phone) to the server(s). Remote processing of electrocardiograms (“ECG”) is achieved, in part, by data streaming packet lengths acquired over no less than 3 seconds—3 seconds is typically equivalent to about 3 cardiac cycles (heartbeats)—to provide the quickest response time by clinicians to try to save a heart patient's life. Other types of physiological data are monitored by the device, so medical help can be obtained when needed. In this manner, any sudden onset of vicissitudes in a patient's well being may be detected and transmitted to the care-giver and patient in near real-time.

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Номер записи: 21

18-10-2012 дата публикации

Advanced analyte sensor calibration and error detection

Номер: US20120265037A1

Автор: Daiting Rong, Peter C. Simpson, Sebastian Böhm

Принадлежит: Dexcom Inc

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

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Номер записи: 22

25-10-2012 дата публикации

Determining Analyte Concentrations in Biological Fluids with Abnormal Output Detection

Номер: US20120271559A1

Автор: Christine D. Nelson, Huan-Ping Wu, Scott Carpenter

Принадлежит: Bayer HealthCare LLC

A biosensor has an abnormal output detection system that determines whether an output signal from the redox reaction of an analyte has a normal or abnormal shape or configuration. The abnormal output detection system improves the accuracy and precision of the biosensor in determining whether an output signal has a shape or configuration that may not provide an accurate and/or precise analysis of a biological fluid. The biosensor generates an output signal in response to the redox reaction of the analyte. The biosensor normalizes the output signal and compares the normalized output signal with one or more control limits. The biosensor may generate an error signal when the normalized output signal is not within the control limits.

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Номер записи: 23

22-11-2012 дата публикации

Manufacturing electrochemical sensor module

Номер: US20120291254A1

Автор: James L. Say

Принадлежит: Individual

Certain processes for manufacturing an electrochemical sensor module include assembly first and second housing portions of sensor modules; dispensing a sensor fiber across multiple first housing portions; joining the first and second housing portions; and separating the sensor modules by cutting the sensor fiber.

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Номер записи: 24

22-11-2012 дата публикации

Method for preparing a catheter assembly including a sensing element having an adhesive backing

Номер: US20120291943A1

Автор: Kenneth M. Curry

Принадлежит: Edwards Lifesciences Corp

The present invention is directed to a sensing element that comprises a flexible substrate having first and second opposite surfaces; at least one sensor disposed on the first surface of the flexible substrate; an adhesive layer substantially covering the second surface of the flexible substrate; and a release liner releasably adhered to the adhesive layer so that upon removal of the release liner the adhesive layer is exposed for securing the sensing element to the catheter. The release liner permits the sensing element to be positioned at a desired location within the catheter after which the release liner can be removed to expose the adhesive layer. The adhesive layer can then be used to attach and secure the sensing element at a desired location on the catheter. As a result, the need for additional adhesives can be reduced or eliminated.

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Номер записи: 25

29-11-2012 дата публикации

Optical thromboelastography system and method for evaluation of blood coagulation metrics

Номер: US20120301967A1

Автор: Seemantini K. Nadkarni

Принадлежит: General Hospital Corp

Device, method, and computer program product for determining a material parameter of a blood coagulation cascade based on parameters of light diffused at a biofluid sample. In one example, the biofluid sample includes a blood sample. Laser light scattered by the sample is collected by the optical system in reflection and/or transmission mode. An image of the sample in so collected light is formed, and data representing fluctuations of laser speckle intensity with is processed to derive numerical descriptors associated with blood coagulation and fibrinolysis. In a specific case, such numerical descriptors are derived based on temporal dynamic of a viscoelastic characteristic of the blood sample.

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Номер записи: 26

29-11-2012 дата публикации

Biometric healthcare data system

Номер: US20120302841A1

Автор: Rudolph J. Liedtke, Timothy W. Coressel

Принадлежит: TELSANO HEALTH

A biometric healthcare data system has biometric data collection stations and a network management system. Each station has several biometric data measurement devices including a bioelectrical impedance analysis system. Each station has a gateway that connects to the devices and that connects the station through the internet to the network management system. The network management system has a communications manager that tracks the stations, a content manager that provides content to the stations and a data manager that retrieves and stores data from the data collection stations.

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Номер записи: 27

13-12-2012 дата публикации

Power management in a data-capable strapband

Номер: US20120316471A1

Автор: Hosain Sadequr RAHMAN, II Max Everett Utter, Jeremiah Robison, Michael Edward Smith Luna, Richard Lee DRYSDALE, Scott Fullam, Thomas Alan Donaldson, Travis Austin BOGARD

Принадлежит: AliphCom LLC

Embodiments of the invention relates generally to electrical and electronic hardware, computer software, wired and wireless network communications, and computing devices, and more specifically to structures and techniques for managing power generation, power consumption, and other power-related functions in a data-capable strapband. Embodiments relate to a wearable band including sensors, a controller coupled to the sensors, an energy storage device, a power port configured to receive power and control signals, and a power manager. The power manager includes at least a transitory power manager configured to control an application of power to one or more components of the wearable band in one or more power modes. The band can be configured as a wearable communications device and sensor platform.

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Номер записи: 28

20-12-2012 дата публикации

Systems and methods for replacing signal artifacts in a glucose sensor data stream

Номер: US20120323100A1

Автор: Aarthi Mahalingam, Apurv Kamath, James H. Brauker, Ying Li

Принадлежит: Dexcom Inc

Systems and methods for minimizing or eliminating transient non-glucose related signal noise due to non-glucose rate limiting phenomenon such as interfering species, ischemia, pH changes, temperatures changes, known or unknown sources of mechanical, electrical and/or biochemical noise, and the like. The system monitors a data stream from a glucose sensor and detects signal artifacts that have higher amplitude than electronic or diffusion-related system noise. The system processes some or the entire data stream continually or intermittently based at least in part on whether the signal artifact event has occurred.

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Номер записи: 29

07-03-2013 дата публикации

Vacuum delivery extractor

Номер: US20130060259A1

Автор: Gadi Porat

Принадлежит: ASSOCIATION FOR PUBLIC HEALTH

A delivery extractor for use with a suction source and at least one monitor in vacuum assisted deliveries. The extractor comprises a cup-shaped element and a tubular stem joined to the cup-shaped element and in pneumatic communication with the suction source. The extractor also includes at least one noninvasive sensor positioned on a sensor support so as to continuously contact the scalp of a fetus when the head of the fetus is positioned in the cup-shaped element. The sensor support is depressible within the cup-shaped element. The at least one sensor is in communication with the monitor(s) which monitors at least one physiological indicator of the well-being of the fetus during its transit through the birth canal. In other cases, the aforementioned noninvasive sensor(s) detects direct waves while other noninvasive sensors positioned on the rim of the cup-shaped element detect surface waves related to the same phenomenon.

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Номер записи: 30

21-03-2013 дата публикации

Portable monitoring devices and methods of operating same

Номер: US20130073254A1

Автор: Eric Nathan Friedman, James Park, Shelten Gee Jao Yuen

Принадлежит: Fitbit LLC

The present inventions, in one aspect, are directed to a portable activity monitoring device to calculate a number of stairs or flights of stairs traversed by a user, the monitoring device comprising (i) a housing having a physical size and shape that is adapted to couple to the body of the user, (ii) an altitude sensor, disposed in the housing, to detect a change in altitude of the user and, in response thereto, to generate data which is representative of the change in altitude of the user, and (iii) processing circuitry, disposed in the housing and coupled to the motion sensor and the altitude sensor, to calculate a number of stairs or flights of stairs traversed by the user using the data which is representative of a change in altitude of the user.

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Номер записи: 31

28-03-2013 дата публикации

DETECTION OF OVARIAN CANCER

Номер: US20130078319A1

Автор: Levine Douglas A.

Принадлежит: Memorial Sloan-Kettering Cancer Center

Among other things, the present disclosure provides a method including the steps of: obtaining a uterine sample; and detecting and/or characterizing in the uterine sample an ovarian cancer biomarker (e.g., CA125). 1. A method comprising steps of:obtaining a uterine sample; andmeasuring in the uterine sample an ovarian cancer biomarker level.2. The method of claim 1 , wherein the ovarian cancer biomarker is CA-125.3. The method of claim 1 , wherein the ovarian cancer biomarker is selected from the group consisting of HE4 claim 1 , mesothelin claim 1 , and YKL-40.4. The method of claim 1 , wherein the step of obtaining comprises obtaining a uterine wash sample.5. The method of claim 1 , wherein the step of obtaining comprises obtaining a sample in vivo.6. The method of claim 5 , wherein the step of measuring occurs in vivo.7. The method of claim 6 , wherein the step of obtaining and the step of measuring are performed via a bio-sensing device implanted in vivo.8. The method of claim 7 , further comprising transmitting a signal from the bio-sensing device to a remote sensor claim 7 , the signal corresponding to data obtained during the step of measuring.9. The method of claim 1 , further comprising adjusting a therapy based on data obtained during the step of measuring.10. The method of claim 1 , further comprising repeatedly performing the step of measuring.11. The method of claim 10 , further comprising adjusting a therapy based on data obtained during the step of repeatedly performing the step of measuring.12. The method of claim 1 , wherein the step of measuring comprises determining that the biomarker is present at a level higher than a reference level.13. The method of claim 12 , wherein the reference level is correlated with presence or absence of cancer.14. The method of claim 12 , wherein the reference level is correlated with absence or presence of cancer at a particular stage.15. The method of claim 1 , wherein the step of measuring comprises determining ...

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Номер записи: 32

04-04-2013 дата публикации

APPARATUS AND METHOD FOR MEASURING A TISSUE ANALYTE SUCH AS BILIRUBIN USING THE BREWSTER'S ANGLE

Номер: US20130085351A1

Автор: Kudavelly Srinivas Rao, Meijer Eduard Johannes

Принадлежит: KONINKLIJKE PHILPS ELECTRONICS N.V.

A tissue analyte measuring device () includes a light source () structured to emit unpolarized light toward the skin surface of a subject, and a detector assembly () configured to receive light reflected the skin surface of the subject and the transcutaneous tissues of the subject, the detector assembly including a polarizing filter () and a number of light detector subassemblies (). The polarizing filter is structured to filter out s-polarized light and pass only p-polarized light to light detector subassemblies. The light source is structured and positioned to emit the unpolarized light in a manner wherein the unpolarized light will exit the measuring device at a predetermined angle with respect to a normal to a light emitting plane of the measuring device, wherein the predetermined angle is an angle (the Brewster's angle) at which only s-polarized light will be reflected by the skin surface when the unpolarized light is incident thereon. 12. A tissue analyte measuring device () , comprising:{'b': 4', '6, 'a light source () structured and positioned to emit unpolarized light toward a skin surface () of a subject when the measuring device is positioned adjacent to the skin surface; and'}{'b': 8', '12', '14, 'a detector assembly () configured to receive light reflected from the subject including light reflected by the skin surface of the subject and by transcutaneous tissues of the subject, the detector assembly including a polarizing filter () and a number of light detector subassemblies (), the polarizing filter being structured to filter out s-polarized light and pass only p-polarized light to the number of light detector subassemblies.'}27. The measuring device according to claim 1 , wherein the light source is structured and positioned to emit the unpolarized light in a manner wherein the unpolarized light will exit the measuring device at a predetermined angle with respect to a normal to a light emitting plane () of the measuring device claim 1 , the light ...

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Номер записи: 33

04-04-2013 дата публикации

Haemodynamic monitoring device

Номер: US20130085357A1

Автор: Martin Peterreins, Stephan Joeken, Wolfgang Huber

Принадлежит: Individual

A relation is formed between an n-tuple having n components and formed at a first point in time and at least one other n-tuple having n components formed at at least one corresponding later point in time, wherein n is a natural number equal to or greater than 1, and the components comprise at least one derived parameter and/or one read-in data value. If this relationship satisfies a predetermined calibration criterion, a calibration signal is triggered and is displayed, and/or automatically triggers a recalibration of the haemodynamic monitoring device. For example, the pulse contour cardiac output PCCO is derived from the arterial pressure curve as the constituent component of a 1-tuple. As long as this differs from the reference cardiac output CO Ref by less than a predefined threshold value, for example 101 or 15% of the reference cardiac output, parameter determination continues without initiating a new calibration. On the other hand, if the deviation exceeds PCCO-CO ref I, the calibration signal is triggered.

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Номер записи: 34

04-04-2013 дата публикации

Methods for Analyte Monitoring Management and Analyte Measurement Data Management, and Articles of Manufacture Related Thereto

Номер: US20130085358A1

Автор: Nathan C. CROUTHER, Timothy C. Dunn

Принадлежит: Abbott Diabetes Care Inc

Generally, methods of analyte monitoring management, and articles of manufacturing related thereto, are provided. The methods include receiving analyte measurement data and analyzing the analyte measurement data for health related parameters. Recommendations are determined for creating or modifying a treatment program based on the analysis, and provided within a user-interface that enables a user to create or modify the treatment program. Further, generally, methods of for managing analyte measurement data, and articles of manufacturing related thereto, are provided. The methods include receiving analyte measurement data that represent data collected over a time period, and analyzing the analyte measurement data for analyte episodes within that time period. Threshold based episodes and/or rate-of-change based episodes may be determined.

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Номер записи: 35

11-04-2013 дата публикации

SYSTEMS, DEVICES, AND METHODS INCLUDING PARAMAGNETIC OSCILLATION, ROTATION, AND TRANSLATION OF HEMOZOIN ASYMMETRIC NANOPARTICLES IN RESPONSE TO DARK-FIELD OR RHEINBERG DETECTION OF THE PRESENCE OF HEMOZOIN

Номер: US20130090535A1

Автор: Hegg Michael C., Horning Matthew P., JR. Lowell L., Kare Jordin T., Myhrvold Nathan P., Tegreene Clarence T., Wilson Benjamin K., Wood

Принадлежит: TOKITAE LLC

Systems, devices, and methods are described for providing a monitor/treatment device configured to, for example, detect hemozoin, as well as to monitor or treat a malarial infection. 111.-. (canceled)12. A method , comprising:generating a comparison between (a) a detected scattering profile information associated with a plurality of target regions within a biological tissue interrogated by a dark-field interrogation stimulus in the presence of a magnetic field stimulus and (b) reference hemozoin dark field scattering information; andmagnetically perturbing hemozoin nanoparticles in the biological tissue based in part on the comparison.13. The method of claim 12 , wherein generating the comparison includes comparing claim 12 , using circuitry claim 12 , a detected scattering profile associated with a plurality of target regions within a biological subject interrogated by a multiplexed dark-field interrogation stimulus in the presence of a magnetic field stimulus and reference hemozoin dark field scattering information.14. The method of claim 12 , further comprising:generating a comparison, using circuitry, between a detected scattering profile obtained using a Rheinberg illumination configuration in the presence of a magnetic field stimulus and reference hemozoin Rheinberg illumination spectral information.15. The method of claim 12 , wherein magnetically perturbing the hemozoin nanoparticles in a biological tissue includes applying a magnetic field stimulus of a character and for a duration sufficient to cause the hemozoin nanoparticles in a biological tissue to affect the integrity of a digestive food vacuole of a malaria parasite.16. The method of claim 12 , wherein magnetically perturbing the hemozoin nanoparticles in a biological tissue includes applying an alternating magnetic field stimulus of a character and for a duration sufficient to cause the hemozoin nanoparticles in a biological tissue to rupture a membrane of a digestive food vacuole of a malaria ...

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Номер записи: 36

11-04-2013 дата публикации

DEVICE FOR CLAMPING A HOSE LINE FOR DETERMINING THE CONCENTRATION OF A BLOOD CONSTITUENT

Номер: US20130090540A1

Автор: Kaiser Martin, Koehler Reinhard, Mueller Carsten, ZHANG Wei

Принадлежит:

A device for clamping a hose line for determining the concentration of a constituent of blood in a hose line, in particular in the hose line of an extracorporeal blood circuit of an extracorporeal blood treatment apparatus, includes a clamping unit with two receiving elements and an electric motor-driven actuation mechanism. Actuation mechanism is constituted such that, when a clamping force is applied, the first and second receiving element can be moved from a position releasing the hose line into a position clamping the hose line. Moreover, the device comprises an unlocking mechanism which is constituted such that, by actuating an unlocking element, the actuation mechanism in the position clamping the hose line can be decoupled from electromotive drive. Unlocking mechanism makes it possible for the receiving elements to be transferred easily and rapidly by hand from the position clamping the hose line into the position releasing the hose line. 1. A device for clamping a hose line for determining a concentration of a constituent of blood in a hose line of an extracorporeal blood circuit of an extracorporeal blood treatment apparatus , comprising:a clamping unit which comprises first and second receiving elements for clamping the hose line;a measurement unit for coupling electromagnetic radiation through the hose line into the blood and measuring the electromagnetic radiation emerging through the hose line from the blood,wherein the clamping unit comprises an actuation mechanism and an electromotive drive for the actuation mechanism, wherein the actuation mechanism is constituted such that, when a clamping force is applied, the first and second receiving elements move from a position releasing the hose line into a position clamping the hose line, andwherein the clamping unit comprises an unlocking mechanism, which is constituted such that, by actuating an unlocking element, the actuation mechanism in the position clamping the hose line is decoupled from the ...

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Номер записи: 37

11-04-2013 дата публикации

AUTOMATED RENAL EVALUATION SYSTEMS AND METHODS USING MRI IMAGE DATA

Номер: US20130090548A1

Автор: Edwards Matthew Stevens, Hamilton Craig Alan, Hundley William Gregory, Rocco Michael Vito

Принадлежит: Wake Forest University Health Sciences

Renal screening systems include a circuit configured to electronically analyze MRI image data of a subject to evaluate renal function and generate a renal-risk report for a plurality of different therapeutic agents based on renal responses to test doses of each of the agents. 1. A renal evaluation system , comprising:a circuit comprising at least one processor configured to: (i) segment cortical and medullary regions of different MRI kidney image slices of a respective patient into defined sub-segments for volume analysis and associate borders of the defined sub-segments with a respective color; (ii) assess oxygenation and perfusion in the defined sub-segments before and after one or more agents are administered to a respective patient; and (iii) generate a color coded image of abdominal fat adjacent a respective kidney of a patient; andat least one display in communication with the circuit configured to display the color coded image of abdominal fat of a patient and at least one image slice of a segmented kidney with defined sub-segments with color borders.2. The system of claim 1 , wherein the defined sub-segments include a total kidney volume claim 1 , a medulla volume claim 1 , and a renal sinus volume claim 1 , and wherein the circuit is configured to analyze each kidney image slice having a slice thickness between about 3 mm to about 20 mm claim 1 , to calculate a cortical volume as equal to total kidney volume minus medulla volume and to calculate a medullary volume as equal to the medulla volume minus the renal sinus volume claim 1 , and wherein the circuit is configured to evaluate whether blood flow changes in response to administered agents preserve or alter renal cortex to medullary volume ratios.3. The system of claim 1 , wherein the circuit is configured to calculate blood flow and percent stenosis of at least one renal artery.4. The system of claim 1 , wherein the circuit is configured to identify whether the patient is likely to benefit or likely not ...

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Номер записи: 38

11-04-2013 дата публикации

COMPONENT AND METHOD FOR ASSEMBLING AN IMPLANT ARRANGEMENT

Номер: US20130090732A1

Автор: DUDA Georg, HELLER Markus

Принадлежит: Synthes USA, LLC

The invention refers to a component for arrangement at an implant as well as a method for the assembling of an implant arrangement. The component comprises a basic component, at least one sensor arranged in the basic component for the detection of a measurement variable and for the generation of measuring data for the detected measurement variable, a telemetry device arranged in the basic component for transmitting and receiving data and a data transmission connection between the at least one sensor device and the telemetry device for the transmission of data between the at least one sensor device and the telemetry device, whereby the data comprise the measuring data. At the basic component, assembly means for mounting the basic component in an implant recess are formed. 120-. (canceled)21. A component for an arrangement at an implant , comprising:a sensor detecting a measurement variable and generating measuring data corresponding to the detected measurement variable;a telemetry device transmitting data;a data transmission connection between the sensor and the telemetry device for the transmission of the measuring data therebetween; andan assembly arrangement detachably mounting the component in an implant recess of the implant wherein the component is configured to be insertable through an implant recess of an implant positioned over a target portion of a bone so that the opening is seated over an outer periphery of the target portion of the bone.22. The component of claim 21 , wherein the assembly arrangement comprises a threaded section configured to be screwed into the implant recess.23. The component of claim 21 , wherein the component comprises a head part and an elongated base part.24. The component of claim 23 , wherein the assembly arrangement comprises a lateral projection extending radially out of the elongated base part claim 23 , the lateral projection being dimensioned to engage a bone-contacting side of the implant such that the component is ...

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Номер записи: 39

18-04-2013 дата публикации

OPTICAL SENSOR DEVICE AND IMAGE PROCESSING UNIT FOR MEASURING CHEMICAL CONCENTRATIONS, CHEMICAL SATURATIONS AND BIOPHYSICAL PARAMETERS

Номер: US20130094730A1

Автор: Segman Yosef

Принадлежит: CNOGA HOLDINGS LTD.

Optical sensor devices, image processing devices, methods and computer readable code computer-readable storage media for detecting biophysical parameters, chemical concentrations, chemical saturations and blood count. In some embodiments, the image processing device receives a live still or video electronic image. Exemplary physiological parameters include but are not limited to a pulse rate, blood pressure, glucose, stroke volume of internal or external tissue (e.g. skin). A biophysical or physiological property is not limited to a cardiovascular or liver or the kidneys or to a cardiovascular disorder or to a pulmonary disorder. Exemplary chemical concentrations or saturation includes but not limited to a pH level, a glucose level, a urea nitrogen level, a CO2 concentration or saturation, or a oxygen concentration or saturation. In some embodiments the parameters are detected from a food or a beverage such as an alcohol, a dairy product, wine, a baked good, a fruit or a vegetable. 1. An image processing device for obtaining biophysical information about a mammalian subject , said image processing device comprising:an image receiving unit for receiving a video electronic color image of a first tissue of the mammalian subject, the electronic color image comprising spatial temporal per pixel information for a color space of a first visible color, spatial temporal per pixel information for a color space of a second visible color and spatial temporal per pixel information for a color space of a third visible color, the electronic color image derived from light reflected from and/or traversing the first tissue, the light incident from a continuous or discontinuous, filtered or unfiltered, natural or artificial, light source and having a wavelength between near UV and near IR; andan image processing unit for electronically processing said image by transforming per pixel information for the first, second and third visible colors to transformed per pixel information for the ...

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Номер записи: 40

18-04-2013 дата публикации

SYSTEM, METHOD AND ARTICLE FOR NORMALIZATION AND ENHANCEMENT OF TISSUE IMAGES

Номер: US20130096392A1

Автор: Adams Bruce

Принадлежит: CERNOVAL, INC.

In medical imaging, a fiducial marker facilitates tissue image correlation that allows for image analysis, normalization and correction of the optical exposure and spectral and spatial distribution in order to compensate for the surface reflections, sub surface tissue interactions and spatial orientation of the excitation and imaging axes to the subject tissue. Using a cross comparison, clinicians can model tissue image data in different forms in order to reference and compare data from various spectral components and or from different images. This may enhance human interpretation between images including the variations between images even when the spectral, spatial and optical conditions or the image resolution or sensitivity are compromised. Such may be used to assess cosmetic, moisturizing, therapeutic materials and treatments. 129.-. (canceled)30. A system for use in tissue analysis , the system comprising:at least one processor; andat least one nontransitory storage medium that stores processor executable instructions which when executed cause the at least one processor to:compare an appearance of at least one shape of at least a first fiducial marker in a first digital image of a portion of a tissue to at least one defined actual shape of the fiducial marker;compare an appearance of each of a plurality of sections of the fiducial marker in the first digital image to respective ones of defined sections of the fiducial marker including a number of tissue phantoms each having a respective spectral characteristic that matches a respective spectral characteristic of tissue of a type represented in the first digital image; andat least one of correlate, normalize, or correct at least the first digital image, based at least in part on the comparisons.31. The system of wherein the fiducial marker includes a scatter layer that overlies at least some of the tissue phantoms and which simulates an optical character of the type of tissue represented in the first digital ...

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Номер записи: 41

18-04-2013 дата публикации

DEVICE FOR MONITORING AND/OR IMPROVING THE EFFICIENCY OF PHYSICAL TRAINING

Номер: US20130096396A1

Автор: Riedel Matthias

Принадлежит: SONY CORPORATION

A device for monitoring the efficiency of physical training in a human or animal includes a millimeter wave generator that generates millimeter wave radiation and a millimeter wave antenna that emits millimeter waves generated by the millimeter wave generator in a predetermined direction. The device includes a coupling element that couples the millimeter wave antenna to the millimeter wave generator and that transmits the millimeter wave radiation to the millimeter wave antenna. The device also includes a reference element that intermittently receives millimeter wave radiation from the millimeter wave antenna and a detector that detects millimeter wave radiation and produces a first data stream. The device further includes a processing unit that receives the first data stream and generates a signal indicating development of a body lactate level over time and an output device indicating the development of the body lactate level over time, to a user. 1. A device for monitoring and/or improving the efficiency of physical training in a human or animal , comprising:at least one millimeter wave generator that generates millimeter wave radiation,at least one millimeter wave antenna that emits millimeter waves generated by said millimeter wave generator in a predetermined direction,at least one coupling element that couples said millimeter wave antenna to said millimeter wave generator and that transmits said millimeter wave radiation generated by said millimeter wave generator to said millimeter wave antenna,at least one reference element, whereby said at least one reference element at least intermittently receives millimeter wave radiation from said millimeter wave antenna,at least one detector that detects millimeter wave radiation and produces a first data stream,a processing unit that receives said first data stream from said at least one detector and generates a signal indicating a development of a body lactate level over time, andan output device indicating said ...

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Номер записи: 42

18-04-2013 дата публикации

MONITORING SYSTEM FOR CARDIAC SURGICAL OPERATIONS WITH CARDIOPULMONARY BYPASS

Номер: US20130096398A1

Автор: Ranucci Marco

Принадлежит: Sorin Group Italia, S.r.l.

A monitoring system for cardiac operations with cardiopulmonary bypass comprising: a processor operatively connected to a heart-lung machine; a pump flow detecting device connected to a pump of the heart-lung machine to continuously measure the pump flow value and send it to the processor; a hematocrit reading device inserted inside the arterial or venous line of the heart-lung machine to continuously measure the blood hematocrit value and to send it to the processor; a data input device to allow the operator to manually input data regarding the arterial oxygen saturation and the arterial oxygen tension; computing means integrated in the processor to compute the oxygen delivery value on the basis of the measured pump flow, the measured hematocrit value, the preset value of arterial oxygen saturation, and the preset value of arterial oxygen tension; and a display connected to the processor to display in real-time the computed oxygen delivery value. 1. A method of monitoring a patient's parameters during a cardiac operation with cardiopulmonary bypass and a heart-lung machine , the method comprising:detecting a pump flow (Qp) value from a pump of the heart-lung machine;detecting a hematocrit (HCT) value from the arterial or venous line of the heart-lung machine;obtaining an arterial oxygen saturation (Sat(a)) value derived from an arterial blood of the patient;obtaining an arterial oxygen tension (PaO2) value derived from the arterial blood of the patient;calculating an oxygen delivery (DO2) value;calculating a carbon dioxide production (VCO2) value; anddisplaying a comparison of the DO2 value and the VCO2 value.2. The method of claim 1 , further comprising calculating a hemoglobin (Hb) value from the HCT value.3. The method of claim 2 , further comprising calculating an arterial oxygen content (CaO2) value from the Hb value claim 2 , the Sat(a) value and the PaO2 value.4. The method of claim 2 , further comprising calculating the DO2 value from the pump flow rate Qp ...

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Номер записи: 43

18-04-2013 дата публикации

System for In Vivo Biosensing Based on the Optical Response of Electronic Polymers

Номер: US20130096406A1

Автор: Arthur J. Epstein, Louis R. Nemzer

Принадлежит: Ohio State University

A system for continuous in vivo biosensing of specific analyte molecule concentrations based on the dynamic optical properties of electronic polymers is disclosed. The biosensor system includes at least one implant member subcutaneously exposed to the interstitial fluid of the subject, and a reader member at least temporarily positioned over the implant member to probe it with light of specific wavelengths through the skin. The system has many potential applications, including the real-time monitoring of blood glucose levels in diabetics as a method to supplement or replace conventional capillary blood testing.

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Номер записи: 44

18-04-2013 дата публикации

METHOD TO DETERMINE SODIUM VALUES DESCRIBING THE CONTENT OF 23NA+, AND LOCAL COIL FOR USE IN SUCH A METHOD

Номер: US20130096415A1

Автор: Cavallaro Alexander, Linz Peter, Niendorf Thoralf, RENZ Wolfgang, Ruff Jan, Santoro Davide, Titze Jens, UDER Michael

Принадлежит:

In a method to determine at least one sodium value describing the 23Na+ content in at least one region of interest in a target region in the body of a patient, at least one sodium image data set of the target region is acquired with a magnetic resonance imaging device using sodium-23 imaging, the sodium image data set including image data dependent on the occurrence of sodium. The at least one region of interest is defined for which the sodium value is to be determined in the sodium image data set. The sodium value is determined by comparison of the image data in the region of interest with reference image data of at least one subject with a defined 23Na+ content, the reference image data having been acquired with the same sequence. A local coil can be used to implement the method that has a phantom integrated therein that allows the sodium image data set and the reference image data to be acquired together. 1. A method to determine at least one sodium value describing 23N+ content in at least one region of interest in a target region in the body of a patient , comprising:operating a magnetic resonance data acquisition unit with a sequence configured for sodium-23 imaging sequence to acquire at least one sodium image data set of a target region of the body of a patient in the magnetic resonance data acquisition unit, said at least one sodium image data set comprising image data dependent on a presence of sodium in said target region;in a computerized processor, defining at least one region of interest for which a sodium value is to be determined in said sodium image data set; andproviding said processor with reference image data also acquired using said sequence configured for sodium-23 imaging sequence and, in said processor, determining said sodium value by comparing image data in said at least one sodium image data set, that represent a region of interest within said target region, with said reference image data.2. A method as claimed in comprising generating ...

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Номер записи: 45

25-04-2013 дата публикации

IMPLANTABLE SENSOR DEVICE AND SYSTEM

Номер: US20130102858A1

Автор: Hill Rolf, Persson Torbjorn, Stegfeldt Olof

Принадлежит: ST. JUDE MEDICAL AB

The implantable medical device for measuring pressure is disclosed. The implantable medical device is connectable to a medical lead and comprises an outer sheath and a helically shaped needle arranged at the outer sheath. A pressure sensing body having a distal part is movably arranged in the outer sheath. The pressure sensing body is arranged such that the distal part is located within the outer sheath in an initial state of the pressure sensing body, wherein the pressure sensing body is arranged to be advanced from the initial state to protrude from the outer sheath and such that it is at least partially surrounded by the helically shaped needle; and a pressure sensor arranged at or adjacent to the distal part of the pressure sensing body for sensing pressure. 115-. (canceled)16. An implantable medical device for measuring pressure connectable to a medical lead , comprising:an outer sheath;a helically shaped needle arranged at said outer sheath;a pressure sensing body having a distal part and being movably arranged in said outer sheath, said pressure sensing body being arranged such that said distal part is located within said outer sheath in an initial state of said pressure sensing body, wherein said pressure sensing body is arranged to be advanced from said initial state to protrude from said outer sheath such that it is at least partially surrounded by said helically shaped needle; anda pressure sensor arranged at or adjacent to said distal part of said pressure sensing body for sensing pressure.17. The implantable medical device according to claim 16 , wherein said helically shaped needle is fixed at said outer sheath or at a distal element fitted in a distal opening of said outer sheath.18. The implantable medical device according to claim 17 , wherein said distal element comprises a through hole arranged such that said pressure sensing body can be advanced through said through hole.19. The implantable medical device for measuring pressure connectable to a ...

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Номер записи: 46

25-04-2013 дата публикации

Systems and Methods for Visualizing Ablated Tissue

Номер: US20130102862A1

Автор: Kay Matthew W., Mercader Marco A., Sarvazyan Narine

Принадлежит: The George Washington University

Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera. 1. A system for imaging tissue comprising:a catheter having an expandable balloon at a distal end;an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native reduced nicotinamide adenine dinucleotide (NADH) in the tissue; andan imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.2. The system of further comprising an ablation device for ablating the tissue.3. The system of claim 1 , wherein the tissue being treated is heart tissue.4. The system of further comprising a display system connected to the camera for generating an image of the illuminated tissue based on the detected NADH fluorescence.5. The system of claim 4 , wherein in the image tissue that was effected by a treatment is illustrated as having less fluorescence than tissue not affected by the treatment6. The system of further comprising a dichroic mirror and a plurality of filters for conditioning light from the light source and light reflected by the tissue.7. A system for imaging tissue comprising:a catheter system configured to position an illumination device and an imaging device in proximity to a tissue;an ablation device ...

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Номер записи: 47

02-05-2013 дата публикации

Simultaneous acquisition of biometric data and nucleic acid

Номер: US20130106568A1

Автор: Lori Hennessy, Michael Harrold, Robert Lagace

Принадлежит: Life Technologies Corp

Disclosed are devices and methods for collection and analyzing biological samples containing nucleic acid in conjunction with collecting at least one ridge and valley signature of a test subject, while keeping the sample and signature associated with each other. Such devices and methods are used in forensic, human identification, screening, and access control technologies to rapidly process an individual's identity or determine the identity of an individual.

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Номер записи: 48

02-05-2013 дата публикации

MEDICAL SENSOR AND TECHNIQUE FOR USING THE SAME

Номер: US20130109936A1

Автор: Baker, Bowman Bruce R., JR. Clark R., Mannheimer Paul D., Middleman Lee M.

Принадлежит: COVIDIEN LP

In an embodiment, a sensor may be adapted to provide information related to its position on a patient's tissue. The sensor may include tissue contact sensors which may relay a signal related to the proper placement of the sensor relative to the tissue of a patient. Such a sensor may be useful for providing information to a clinician regarding the location of the sensor in relation to the skin of a patient in order to provide improved measurements. 1. A system comprising:a sensor body;an emitter and a detector disposed adjacent the sensor body; anda tissue contact sensor disposed adjacent the sensor body, wherein the tissue contact sensor comprises a temperature sensor configured to measure a temperature; anda processor coupled to the tissue contact sensor configured to determine whether the sensor is on a tissue of a patient based, at least in part, on the measured temperature.2. The system of claim 1 , wherein the temperature sensor comprises a thermistor.3. The system of claim 1 , wherein the processor is configured to compare the measured temperature to a threshold value to determine whether the sensor is on the tissue of the patient.4. The system of claim 3 , wherein the threshold value comprises a clinically determined average skin surface temperature.5. The system of claim 1 , wherein the tissue contact sensor comprises a second temperature sensor configured to measure an ambient temperature.6. The system of claim 5 , wherein the processor is configured to determine whether the sensor is on the tissue of the patient based claim 5 , at least in part claim 5 , on a difference between the measured temperature and the measured ambient temperature.7. A pulse oximetry system comprising:a pulse oximetry monitor comprising a processor; and a sensor body;', 'an emitter and a detector disposed adjacent the sensor body; and', 'a tissue contact sensor disposed adjacent the sensor body, wherein the tissue contact sensor comprises a temperature sensor configured to provide ...

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Номер записи: 49

02-05-2013 дата публикации

Biological information processing method and device, recording medium and program

Номер: US20130110409A1

Автор: Kazuhiro Sakurada

Принадлежит: Sony Corp

Provided is a biological information processing method and a device, a recording medium and a program that are able to predict and control changes in the state of an organism. The expression level of molecules in an organism is measured over a specific time interval; the measured time-series data is divided into a periodic component, an environmental stimulus response component and a baseline component; constant regions of the time-series data are identified from variations in the baseline component or from the amplitude or periodic variations of the periodic component; and causal relation between the identified constant regions is identified. The relation between the external environment and variations in the internal environment is identified and from the identified causal relation between the constant regions, changes in the state of the organism are inferred.

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Номер записи: 50

09-05-2013 дата публикации

Sample cell for fluid analysis system

Номер: US20130114068A1

Автор: Eugene Lim, Roger Tong

Принадлежит: Optiscan Biomedical Corp

Systems and method are disclosed for determining a concentration of an analyte (e.g., glucose) in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A centrifuge motor can spin the sample cell to separate the fluid into a plurality of components (plasma, red blood cells, etc.). A particular component of the fluid (e.g., plasma) may be positioned at a sample portion of the sample cell after centrifuging such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a cuvette that has two window pieces sandwiched between two clamshell pieces, and where the sample portion of the sample cell is defined by a gap between the window pieces.

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Номер записи: 51

09-05-2013 дата публикации

APPARATUS, SYSTEM, AND METHOD FOR SEIZURE SYMPTOM DETECTION

Номер: US20130116514A1

Автор: Kroner Barbara, Pitruzzello Ann, Shorey Jamie, Strube David C.

Принадлежит: Research Triangle Institute

An apparatus, system, and method are disclosed for detecting seizure symptoms in an individual . A sensor module receives physiological data for an individual from one or more sensors , such as a heart activity sensor. A feature detection module detects a predefined feature in the physiological data. The predefined feature is associated with a seizure or another medical condition. An alert module broadcasts an alert in response to the feature detection module detecting the predefined feature 1. An apparatus to detect seizure symptoms , the apparatus comprising:a sensor module that receives heart activity data for an individual from a heart activity sensor;a feature detection module that detects a predefined feature in the heart activity data, the predefined feature associated with a seizure; andan alert module that broadcasts an alert in response to the feature detection module detecting the predefined feature.2. The apparatus of claim 1 , further comprising a confirmation feature module that detects one or more additional predefined features associated with a seizure in additional data for the individual from one or more additional sensors claim 1 , wherein the sensor module receives the additional data from the one or more additional sensors and wherein the alert module broadcasts the alert in response to the confirmation feature module detecting the one or more additional predefined features.3. The apparatus of claim 2 , wherein the one or more additional sensors include a respiration sensor and the one or more additional predefined features comprise one or more of a predefined increase in an integrated respiration waveform claim 2 , a predefined increase in respiration amplitude claim 2 , a predefined change in respiration rate claim 2 , a breath of at least a predefined duration claim 2 , a breath of at least a predefined amplitude claim 2 , a breath of at least a predefined volume claim 2 , and a predefined change in a period of a respiration interval.4. The ...

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Номер записи: 52

09-05-2013 дата публикации

Holder and light measurement device employing same

Номер: US20130116521A1

Автор: Akihiro Ishikawa, Haruhide Udagawa, Satoru Kohno, Takashi Amita, Yoshihiro Inoue, Yoshinori Masuda

Принадлежит: Shimadzu Corp

Provided is a holder which comprises at least two probe mount portions into which a light-transmitting probe for emitting light from the tip thereof or a light-receiving probe for receiving light through the tip thereof is inserted from above and is to be put on the head of a subject, the holder being characterized by further comprising: a linear backbone portion that extends in a first direction that is perpendicular to the above-described direction from above; and at least two linear branch portions that extend in a second direction that is perpendicular to the above-described direction from above and is different from the first direction, wherein the lower end portions of the probe mount portions protrude from the lower surface of the backbone portion or a branch portion and are tapered.

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Номер записи: 53

16-05-2013 дата публикации

Systems and methods for determining physiological parameters using measured analyte values

Номер: US20130123592A1

Автор: Peter Rule

Принадлежит: Optiscan Biomedical Corp

Systems and methods for determining a physiological parameter in a patient are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a fluid sample received from a patient, a medical sensor configured to measure second analyte data in the patient, and a processor configured to receive the first analyte data and the second analyte data and to determine a physiological parameter based at least in part on the first analyte data and the second analyte data. In certain such embodiments, the medical sensor may be a pulse oximeter, and the physiological parameter may include a cardiovascular parameter including, for example, cardiac output.

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Номер записи: 54

23-05-2013 дата публикации

Methods and systems for in vivo clinical data measurement of analytes

Номер: US20130131470A1

Автор: Jeffrey Galinkin, Keith Hoffman, Uwe Christians

Принадлежит: University of Colorado

The present invention provides apparatuses, systems, and methods for real-time measuring of analytes in a biological fluid sample of a subject. In particular, the present invention provides a combination of micro-dialysis catheter, a micro-volume pump, and a spectrometer device that are operatively connected to one another to provide real-time measurement of analytes in a biological fluid sample of a subject.

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Номер записи: 55

23-05-2013 дата публикации

Non-invasive ocular monitoring

Номер: US20130131472A1

Автор: Naresh Menon

Принадлежит: CHROMOLOGIC LLC

A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light.

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Номер записи: 56

23-05-2013 дата публикации

PHOTOPLETHYSMOGRAPHY DEVICE AND METHOD

Номер: US20130131475A1

Автор: Eisen Leon, Fine Ilya, Kamisnky Alexander

Принадлежит:

A system and method for measuring one or more light-absorption related blood analyte concentration parameters of a mammalian subject, is disclosed. In some embodiments, the system comprises: a) a photoplethysmography (PPG) device configured to effect a PPG measurement by illuminating skin of the subject with at least two distinct wavelengths of light and determining relative absorbance at each of the wavelengths; b) a dynamic light scattering measurement (DLS) device configured to effect a DLS measurement of the subject to rheologically measure a pulse parameter of the subject; and c) electronic circuitry configured to: i) temporally correlating the results of the PPG and DLS measurements; and ii) accordance with the temporal correlation between the PPG and DLS measurements, assessing value(s) of the one or more light-absorption related blood analyte concentration parameter(s). 1. A method of measuring one or more light-absorption related blood analyte concentration parameters of a mammalian subject , the method comprising:a) effecting a photoplethysmography (PPG) measurement of the subject by illuminating skin of the subject with at least two distinct wavelengths of light and determining relative absorbance at each of the wavelengths;b) effecting a dynamic light scattering measurement (DLS) of the subject to rheologically measure a pulse parameter of the subject;c) temporally correlating the results of the PPG and DLS measurements; andd) in accordance with the temporal correlation between the PPG and DLS measurements, assessing value(s) of the one or more light-absorption related blood analyte concentration parameter(s).2. The method of wherein the blood analyte concentration parameter is selected from the group consisting of a blood oxihemoglobin concentration parameter claim 1 , a blood carboxyhemoglobin concentration parameter and an arteriovenous oxygen difference (AV difference) parameter.3. The method of wherein temporal correlating and/or value assessing ...

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Номер записи: 57

23-05-2013 дата публикации

PULSE OXIMETRY SYSTEM

Номер: US20130131477A1

Автор: Abdalkhani Arman, Siu Stanley C.

Принадлежит: Oneeros, Inc.

Systems and methods for estimating a saturation level of oxygen in hemoglobin (SpO2) are provided. In some aspects, a system includes a detector module configured to receive an oximeter output signal indicative of light absorption in a patient. The oximeter output signal alternates between infrared light components and red light components, and includes a first portion obtained at least partly during switching from at least one of the infrared components to at least one of the red components. The oximeter output signal also includes a second portion obtained at least partly during switching from at least one of the red components to at least one of the infrared components. The system also includes a processing module configured to estimate an SpO2 of the patient as a ratio between (i) a time derivative of the first portion and (ii) a time derivative of the second portion. 1. A system , for estimating a saturation level of oxygen in hemoglobin (SpO) , comprising: a first portion obtained at least partly during switching from at least one of the infrared components to at least one of the red components; and', 'a second portion obtained at least partly during switching from at least one of the red components to at least one of the infrared components; and, 'a detector module configured to receive an oximeter output signal indicative of light absorption in a patient, the oximeter output signal alternating between infrared light components and red light components and comprising{'sub': '2', 'a processing module configured to estimate an SpOof the patient as a ratio between (i) a time derivative of the first portion and (ii) a time derivative of the second portion.'}2. The system of claim 1 , wherein the oximeter output signal alternates between the infrared light components and the red light components according to a predetermined frequency.3. The system of claim 2 , wherein the time derivative of the first portion is with respect to a switching time duration claim 2 , ...

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Номер записи: 58

30-05-2013 дата публикации

SYSTEM FOR THE EARLY DETECTION OF LIFE-THREATENING CONDITIONS OF PERSONS

Номер: US20130137941A1

Автор: Schardey Anne

Принадлежит:

The invention relates to a system for the early detection of life-threatening conditions of persons, wherein such risks exist, for example, due to a preceding operation. The system detects a plurality of vital parameters depending on the person to be monitored by means of a detector unit that is subsequently evaluated by an evaluation logic using a neuronal network. Individual parameters that exceed thresholds and constellations of parameters that represent a critical health condition of the person are displayed in different forms by means of a display device, depending on the risk. Said risk is determined in that the probability of the presence of a health anomaly is first determined and then evaluated. 1. A system that detects early a life-threatening condition of a person , comprising:a detector unit that records a plurality of vital parameters, wherein the detector unit optionally comprises a measuring sensor, computing unit, and an interface;an evaluation logic, which assigns a predefined condition to each vital parameter, and which assesses a probability of a health anomaly as a function of the assigned conditions; anda display device which displays the assessment.2. The system of claim 1 , wherein the evaluation logic generates claim 1 , based on the recorded parameters and assigned conditions claim 1 , taking into consideration their variation in time claim 1 , an instruction on how to deal with a momentary condition of the person.3. The system of claim 2 , wherein the instruction is displayed at least partly by the display device.4. The system of claim 1 , wherein the evaluation logic comprises a neuronal network.5. The system of claim 1 , wherein the detector unit records at least one of the vital parameters at a predefined time interval.6. The system of claim 1 , wherein the evaluation logic comprises a fuzzy logic algorithm.7. The system of claim 4 , wherein the neuronal network is trainable by incorporating individual medical data of the person.8. The ...

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Номер записи: 59

30-05-2013 дата публикации

Signal Processing Method, Signal Processing Apparatus, and Pulse Photometer Using the Same

Номер: US20130137948A1

Автор: Yarita Masaru

Принадлежит: Nihon Kohden Corporation

A method of processing first and second signals obtained by measuring a medium, to obtain a pulse wave signal and an artifact signal which are separated, includes: separating vectors of the first and second signals by using a separation matrix into a vector of the pulse wave signal and a vector of the artifact signal, the separation matrix including a norm ratio of a stable zone of the pulse wave signal and a compensated norm ratio of an artifact zone. 1. A method of processing first and second signals obtained by measuring a medium , to obtain a pulse wave signal and an artifact signal which are separated , the method comprising:separating vectors of the first and second signals by using a separation matrix into a vector of the pulse wave signal and a vector of the artifact signal, the separation matrix including a norm ratio of a stable zone of the pulse wave signal and a compensated norm ratio of an artifact zone.3. The method according to claim 1 , wherein a moving average process with a predetermined number of points is performed on the pulse wave signal.4. A biological signal processing apparatus comprising:a measuring unit measuring the first and second signals; and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a processing unit processing the first and second signals by using the method according to .'}5. A pulse photometer including the biological signal processing apparatus according to claim 4 , and calculating at least one of an oxygen saturation of arterial blood claim 4 , a dyshemoglobin concentration claim 4 , and dye concentration injected in the blood claim 4 ,wherein the first and second signals are electric signals into which lights obtained by causing two kinds of light beams, which are emitted from a light emitter and which have different wavelengths, to be transmitted through or reflected from living tissue corresponding to the medium are converted, andwherein a component of the artifact signal is removed by using the compensated norm ratio ...

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Номер записи: 60

30-05-2013 дата публикации

Skin Permeation Device for Analyte Sensing or Transdermal Drug Delivery

Номер: US20130137951A1

Автор: Debashis Ghosh, HAN Chuang, James P. Hurley, Juan P. Eslava, Keith Krystyniak, Scott C. Kellogg

Принадлежит: Echo Therapeutics Inc

Devices, systems, kits and methods for increasing the skin's permeability controlled by measured skin electrical parameter are described herein. They may be used for transdermal drug delivery and/or analyte extraction or measurement. The controlled abrasion device contains (i) a hand piece, (ii) an abrasive tip, (iii) a feedback control mechanism, (iv) two or more electrodes, and (v) an electrical motor. Preferably the feedback control mechanism is an internal feedback control mechanism. In this embodiment, the abrasive tip contains two electrodes, i.e. both the source electrode and the return electrode. In another embodiment, the feedback control mechanism is an external feedback control. In the preferred embodiment for external feedback control, the device contains a co-axial or concentric arrangement of the two electrodes. In this embodiment, the abrasive tip contains the source electrode and the return electrode is located at the proximal end of the hand piece. The abrasive tip can be made of any material with a surface that can abrade skin. The material can be conductive or non-conductive. The controlled abrasion device may be provided in a kit, where the kit contains the device, one or more abrasive tips, optionally with a wetting fluid. The method for increasing the skin's permeability requires applying the controlled abrasion device to a portion of the skin's surface for a short period of time. The desired level of skin impedance, and thus the resulting permeability of the treated site, can be set at a predetermined value. Alternatively, the level of skin impedance can be selected based on the desired level of skin integrity, the subject's sensation of discomfort, or the duration of the application. The device contains a control mechanism which uses an appropriate algorithm or signal processing on the conductivity information provided by the electrodes to determine when the desired level of skin permeability has been reached. Once the desired ...

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Номер записи: 61

30-05-2013 дата публикации

Delivering and/or receiving fluids

Номер: US20130138058A9

Автор: A. David Boccuti, Christopher J. Morse, Donald E. Chickering, III, Greg Fisher, Javier Gonzalez-Zugasti, Maisam Dadgar, Mark Michelman, Ramin Haghgooie, Richard L. Miller, Scott James, Shawn Davis

Принадлежит: Seventh Sense Biosystems Inc

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

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Номер записи: 62

06-06-2013 дата публикации

NMR SYSTEMS FOR IN VIVO DETECTION OF ANALYTES

Номер: US20130144134A1

Автор: Berry David A., Lee W. David

Принадлежит: T2 Biosystems, Inc.

This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response. 1. A nuclear magnetic resonance system for assessing the presence or concentration of an analyte contained in a body fluid of a mammal in-vivo , the system comprising:(a) a sensor suitable for partial or complete implantation within the mammal's body, the sensor comprising structure defining a sample volume and a port, the sample volume containing magnetic particles, and the port allowing the analyte to enter the sample volume and preventing, partly or completely, the magnetic particles from leaving the sample volume, the extent of aggregation of the magnetic particles being indicative of the presence or concentration of the analyte in the sample volume;(b) a reader for disposition outside the mammal's body, the reader providing results based on sensor indication of presence or concentration of the analyte in the sample volume;(c) a magnet or magnetic field generator;(d) a radiofrequency coil for applying a radiofrequency pulse sequence to the sample volume in the presence of a magnetic field provided by the magnet or magnetic field generator; and(e) means for determining the position of the sensor within the mammal's body.2. The system of claim 1 , wherein the radiofrequency coil acts as a sensing radiofrequency coil and an excitation radiofrequency coil.3. The system of claim 1 , wherein the sensor comprises the radiofrequency coil of (d) or a further radiofrequency coil.4. The system of claim 1 , wherein the reader comprises the radiofrequency coil of (d) or a ...

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Номер записи: 63

06-06-2013 дата публикации

METHOD AND SYSTEM FOR NON-INVASIVELY MONITORING BIOLOGICAL OR BIOCHEMICAL PARAMETERS OF INDIVIDUAL

Номер: US20130144137A1

Автор: BARELLY Revital, Belkin Michael, BIEDERMAN Yevgeny, Garcia Javier, MARGALIT Israel, MICO Vicente, Zalevsky Zeev

Принадлежит:

A system and method are presented for use in monitoring one or more conditions of a subject's body. The system includes a control unit which includes an input port for receiving image data, a memory utility, and a processor utility. The image data is indicative of data measured by a pixel detector array and is in the form of a sequence of speckle patterns generated by a portion of the subject's body in response to illumination thereof by coherent light according to a certain sampling time pattern. The memory utility stores one or more predetermined models, the model comprising data indicative of a relation between one or more measurable parameters and one or more conditions of the subject's body. The processor utility is configured and operable for processing the image data to determine one or more corresponding body conditions; and generating output data indicative of the corresponding body conditions. 1. A system for use in monitoring one or more conditions of a subject's body , the system comprising a control unit comprising:an input port for receiving image data measured by a pixel detector array and being in the form of a sequence of speckle patterns generated by a portion of the subject's body in response to illumination thereof by coherent light according to a certain sampling time pattern;a memory utility for storing one or more predetermined models, the model comprising data indicative of a relation between one or more measurable parameters and one or more conditions of the subject's body; and processing the image data and determining a spatial correlation function between successive speckle patterns in the sequence, and determining a time varying spatial correlation function in the form of a time-varying function of at least one feature of the correlation function, the time-varying spatial correlation function being indicative of a change of the speckle pattern over time;', 'selecting at least one parameter of the time-varying spatial correlation function, ...

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Номер записи: 64

06-06-2013 дата публикации

SLEEP APNEA DETECTION SYSTEM

Номер: US20130144190A1

Автор: Bennet Kevin E., Bruce Charles J., Friedman Paul A., Somers Virend K.

Принадлежит: Mayo Foundation for Medical Education and Research

This document provides methods and materials (e.g., systems) related to assessing sleep conditions (e.g., sleep apnea). 1. A method for assessing sleep of a human in a normal sleep environment , wherein said method comprises:(a) detecting audible sounds from said human in said normal sleep environment using a mobile electronic device having a sound sensor, and(b) determining whether said audible sounds are indicative of normal sleep or a disorder present in said human.28-. (canceled)9. The method of claim 1 , wherein said audible sounds comprise snoring sounds of said human claim 1 , and said determining step comprises determining that said audible sounds are indicative of normal sleep.10. (canceled)11. The method of claim 1 , wherein said audible sounds comprise snoring sounds of said human claim 1 , and said determining step comprises determining that said audible sounds are indicative of said disorder.1214-. (canceled)15. The method of claim 11 , wherein said method comprises informing said human via said mobile device that said human has said disorder.16. The method of claim 1 , wherein said audible sounds comprise snoring sounds of said human claim 1 , and said determining step comprises determining that said audible sounds are indicative of sleep apnea.17. The method of claim 16 , wherein said method comprises informing said human via said mobile device that said human has sleep apnea.18. The method of claim 1 , wherein said audible sounds comprise snores of said human claim 1 , and said determining step comprises assessing the amplitude of said snores claim 1 , the interval between said snores claim 1 , the frequency composition of snores claim 1 , or the duration of snores.19. The method of claim 1 , wherein said audible sounds comprise snores of said human claim 1 , and said determining step comprises assessing the amplitude of said snores claim 1 , the interval between said snores claim 1 , the frequency composition of snores claim 1 , and the duration of ...

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Номер записи: 65

06-06-2013 дата публикации

IMPLANTABLE WIRELESS SENSOR SYSTEMS

Номер: US20130144379A1

Автор: Baranowski Jacek Rysard, Goetzinger David Joseph, Najafi Nader

Принадлежит: Integrated Sensing Systems, Inc.

In some embodiments, a cardiac monitoring system includes multiple sensors configured for implantation in a cardiovascular system of a user. Each sensor includes a sensing unit configured to be disposed in sensory communication with the location for measuring a biological parameter in the at least one heart chamber. The sensing unit is also configured to generate a sensory signal associated with the biological parameter. Each sensor also includes a wireless transceiver configured to receive the sensory signal from the sensing unit. The wireless transceiver is further configured to wirelessly transmit the sensory signal to an external processing device disposed outside a body of the user. The external processing device monitors, based on the sensory signal received from at least two sensors from the plurality of sensors, cardiac health associated with at least one of an implanted device or a surgery. 1. A cardiac monitoring system , comprising: a sensing unit configured to be disposed in sensory communication with a location in the cardiovascular system for measuring a biological parameter in the location, said sensing unit configured to generate a sensory signal associated with the biological parameter; and', 'a wireless transceiver configured to receive the sensory signal from the sensing unit and configured to wirelessly transmit the sensory signal to an external processing device disposed outside a body of the user,, 'a plurality of sensors configured for implantation in a cardiovascular system of a user, each sensor from the plurality of sensors includingsuch that the external processing device monitors, based on the sensory signal received from at least two sensors from the plurality of sensors, cardiac health associated with at least one of an implanted device or a surgery.2. The system of claim 1 , wherein the location for each sensor from the plurality of sensors includes at least one of a heart chamber claim 1 , a heart wall claim 1 , a vein claim 1 , or an ...

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Номер записи: 66

13-06-2013 дата публикации

Apparatus and program for evaluating biological function

Номер: US20130150687A1

Автор: Kato Toshinori

Принадлежит:

An apparatus and a program are provided which are capable of simultaneously measuring, evaluating, imaging and displaying the biological function of sites with different biological functions, such as the brain and the muscle, different parts of the brain or different muscle locations, using near-infrared spectroscopy. In an apparatus for evaluating biological function K, physiological indices, including parameters derived from changes in deoxyhemoglobin concentration and changes in oxyhemoglobin concentration, are calculated by a calculating part of a controller. To measure simultaneously, evaluate, image and display the biological functions of sites with different biological function, such as the brain and the muscle, different parts of the brain or different muscle locations, these physiological indices from different sites of the living body are adjusted in such a way that they can be compared with each other by the calculating part and displayed by a display part. 1. An apparatus for evaluating biological function that is an apparatus for evaluating biological function having a plurality of living body probes for irradiating light to and receiving emitted light from a plurality of sites with different biological functions of a living body , and an apparatus body for entering light information detected by means of said plurality of living body probes and performing calculation , control and memory operations , and utilizing the near-infrared spectroscopy method , wherein said plurality of sites of said living body with different biological functions include at least a brain site and a muscle site , wherein said apparatus body comprising:a calculating part for calculating amounts of change in oxyhemoglobin concentration and amounts of change in deoxyhemoglobin concentration and/or physiological indices including a variety of parameters derived from the relationships between them, based on light information from said plurality of living body probes;an adjusting ...

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Номер записи: 67

13-06-2013 дата публикации

INTUITIVE PRESENTATION OF VENTILATION EFFECTIVENESS

Номер: US20130150734A1

Автор: Brewer Lara, Goerges Matthias, Orr Joseph Allen, Westenskow Dwayne Ronald

Принадлежит: KONINKLIJKE PHILIPS ELECTRONICS N.V.

Ventilation information may be presented. Output signals may be received that convey information related to one or more breathing parameters of a subject receiving assisted or controlled mechanical ventilation. Based at least in part on the received output signals, volumetric components of a tidal volume of the subject may be determined. The volumetric components may include an alveolar dead space, an effective alveolar tidal volume, and/or other volumetric components. The alveolar dead space is the volume of inspired gas that occupies alveoli but does not take part in oxygen exchange in the lungs of the subject. The effective alveolar tidal volume is the volume of inspired gas that takes part in oxygen exchange in the lungs of the subject. A visual representation that textually or graphically represents the tidal volume, and/or textually or graphically represents the volumetric components separately from each other may be presented via a user interface. 1. A method for presenting ventilation information , the method comprising:receiving output signals conveying information related to one or more breathing parameters of a subject being mechanically ventilated;determining, based on the received output signals, volumetric components of a tidal volume of the subject, the volumetric components including (i) an alveolar dead space, and (ii) an effective alveolar tidal volume, the alveolar dead space being the volume of inspired gas that occupies alveoli but does not take part in oxygen exchange in the lungs of the subject, and the effective alveolar tidal volume being the volume of inspired gas that takes part in oxygen exchange in the lungs of the subject; andpresenting, via a user interface, a visual representation least a portion of a human respiratory system (i) that provides updated ventilation information in an ongoing manner and (ii) that textually or graphically represents the tidal volume and the volumetric components in a manner which makes analysis of (ii)(a) ...

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Номер записи: 68

13-06-2013 дата публикации

Personal items network, and associated methods

Номер: US20130151699A1

Автор: Adrian F. Larkin, Burl W. Amsbury, Curtis A. Vock, Paul Jonjak, Perry Youngs

Принадлежит: Apple Inc

A personal items network, comprising a plurality of items, each item having a wireless communications port for coupling in network with every other item, each item having a processor for determining if any other item in the network is no longer linked to the item, each item having an indicator for informing a user that an item has left the network, wherein a user may locate lost items. A method for locating lost personal items, comprising: linking at least two personal items together on a network; and depositing one or both of time and location information in an unlost item when one of the items is lost out of network.

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Номер записи: 69

20-06-2013 дата публикации

Activity Monitoring Systems and Methods of Operating Same

Номер: US20130158369A1

Автор: Friedman Eric Nathan, Park James, Yuen Shelten Gee Jao

Принадлежит: Fitbit, Inc.

The present inventions, in one aspect, is an activity monitoring system comprising a fixture having size/shape adapted to couple to a location on the user's body and a particular signature; and a portable monitoring device adapted to detect the fixture's particular signature. The monitoring device includes a housing that is adapted to engage the fixture; an activity sensor, disposed in the housing, to detect activity of the user and to generate data which is representative of the activity of the user; and processing circuitry, disposed in the housing, to calculate an activity-related quantity of the user, wherein the processing circuitry determines the monitoring device is engaging the fixture by detecting the fixture's particular signature and calculates the activity-related quantity. 1. An activity monitoring system comprising:a plurality of fixtures, wherein each fixture includes a physical size and shape that is adapted to couple to an associated location on the body of the user; a housing to separately and physically engage each fixture;', 'an activity sensor, disposed in the housing, to detect activity of the user and, in response thereto, to generate data which is representative of the activity of the user; and', automatically determines a particular fixture of the plurality of fixtures is physically engaging the portable monitoring device, and', 'calculates at least one activity-related quantity of the user which is associated with the particular fixture., 'processing circuitry, disposed in the housing and coupled to the activity sensor, to calculate one or more activity-related quantities of the user using the data which is representative of the activity of the user, wherein the processing circuitry], 'a portable monitoring device adapted to separately and physically engage each fixture of the plurality of fixtures, the portable monitoring device including2. The activity monitoring system of wherein:at least one fixture of the plurality of fixtures includes ...

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Номер записи: 70

20-06-2013 дата публикации

IONIC BARRIER FOR FLOATING GATE IN VIVO BIOSENSORS

Номер: US20130158378A1

Автор: Berger Paul R., Ramesh Anisha

Принадлежит: The Ohio State University

An ion-sensitive sensor includes a dielectric layer comprising AlOhaving a functionalized surface configured to bond with an analyte. The ion-sensitive sensor is immersed in an electrolytic solution containing a concentration of alkali ions. An electrode is arranged to apply an electric potential to the functionalized surface of the ion-sensitive sensor. In some embodiments the ion-sensitive sensor is an ion-sensitive silicon FET. In some embodiments the ion-sensitive sensor is an ion-sensitive polymer FET. In some embodiments, the electrode comprises a perforated gate metal layer disposed on the gate dielectric layer of an ion-sensitive FET, and the functionalized surface is disposed in openings of the perforated gate metal layer. In some embodiments the dielectric layer comprises a multi-layer dielectric stack including at least one AlOlayer. In some embodiments the dielectric layer is deposited by atomic layer deposition (ALD). 1. A system comprising:{'sub': 2', '3, 'an ion-sensitive sensor that includes a dielectric layer including AlO;'}an electrolytic solution in which the ion-sensitive sensor is immersed, the electrolytic solution containing a concentration of alkali ions, a surface of the dielectric layer of the ion-sensitive sensor being in contact with the electrolytic solution; andan electrode arranged to apply an electric potential to the surface of the dielectric layer in contact with the electrolytic solution.2. The system of claim 1 , wherein the surface of the dielectric layer in contact with the electrolytic solution is a functionalized surface configured to bond with an analyte.3. The system of claim 2 , wherein the ion-sensitive sensor is an ion-sensitive silicon field effect transistor (FET) and the dielectric layer in contact with the electrolytic solution is the gate dielectric layer of the ion-sensitive silicon FET.4. The system of claim 3 , wherein the electrode comprises a perforated gate metal layer disposed on the gate dielectric layer of ...

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Номер записи: 71

27-06-2013 дата публикации

Fluid injection and safety system

Номер: US20130160532A1

Автор: Eugene Lim, Gil Rivas, Jeffrey T. Chiou, Michael Butler

Принадлежит: Optiscan Biomedical Corp

Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port.

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Номер записи: 72

27-06-2013 дата публикации

Analyte Sensor

Номер: US20130165756A1

Автор: Brister Mark, Kamath Apurv U., Simpson Peter C.

Принадлежит: DexCom, Inc.

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. 1. A method for measuring an analyte in a host , comprising:exposing a continuous analyte detection system to a sample, wherein the continuous analyte detection system comprises a continuous analyte sensor configured for contact with a sample from a circulatory system of a host in vivo and configured to generate a first signal associated with a test analyte and a second signal associated with a reference analyte, and a reference sensor configured to generate a reference signal associated with the reference analyte;receiving the first signal, the second signal, and the reference signal;calculating a calibration factor associated with a sensitivity of the continuous analyte sensor; andcalibrating the first signal, wherein calibrating comprises using the calibration factor.2. The method of claim 1 , wherein the exposing step further comprises simultaneously exposing the continuous analyte sensor and the reference sensor to the sample.3. The method of claim 1 , wherein the receiving step further comprises receiving the first signal from a first working electrode disposed under an enzymatic portion of a membrane system.4. The method of claim 3 , wherein the receiving step further comprises receiving the second signal from the first working electrode.5. The method of claim 3 , wherein the receiving step further comprises receiving the second signal from a second working electrode disposed under the membrane system.7. The method of claim 5 , wherein the receiving step further comprises receiving a non-analyte-related signal from a third working electrode disposed under a non-enzymatic portion of the membrane system.8. The method of claim 1 , wherein ...

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Номер записи: 73

27-06-2013 дата публикации

Noninvasive detection of meconium in amniotic fluid

Номер: US20130165816A1

Автор: Gideon Mor

Принадлежит: Individual

Meconium stained amniotic fluid can indicate intrauterine fetal distress. The invention provides a system and method for detecting meconium in released amniotic fluid in pregnant women, including a collection body such as a hygienic pad, having a meconium detector. This invention is designed to be employed mainly by a lay person at home; it also may provide possible etiologies for fetal distress.

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Номер записи: 74

04-07-2013 дата публикации

Emergency Medical Diagnosis and Communications Device

Номер: US20130172689A1

Автор: Dossas Vasilios D., Dy Lady C., Kraft Clifford H.

Принадлежит:

A portable emergency medical device capable of communicating with a remote location preferably as a cellular telephone that can measure one or more human vital parameters such as pulse rate, body temperature, skin moisture, blood pressure, ECG or blood chemistry and can receive symptoms from a user either by voice recognition or by keypad and can provide an expert medical diagnosis. The device can store a complete medical history for one or more users and can use an expert system to make the diagnosis. The device can make an emergency medical call either on command or automatically requesting help and optionally supplying medical information and/or GPS location information. 1. A personal medical diagnosis apparatus comprising:a cellular telephone module including a processor and memory;a medical expert system disposed in said memory and executable on said processor;a medical probe that measures at least one human medical parameter, said probe being in data communication with said medical expert system; andan input device, including a keyboard and circuitry through which the medical expert system receives symptom data;the expert system receiving imputed symptom data and at least one medical parameter and making a medical diagnosis.2. The personal medical diagnosis apparatus of further comprising a GPS receiver in communication with said processor claim 1 , wherein said processor is adopted to report a geographic location of said medical diagnosis apparatus to a remote station.3. The personal medical diagnosis apparatus of further comprising a housing wherein said medical probe is at least one of:a blood pressure sensor in or deployable from said housing;a pulse rate sensor in or deployable from said housing;a body temperature sensor in or deployable from said housing, or;an ECG interface in or deployable from said housing.4. The personal medical diagnosis apparatus of further comprising a housing wherein said medical probe is at least one of:a blood pressure sensor ...

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Номер записи: 75

04-07-2013 дата публикации

Health monitoring appliance

Номер: US20130172691A1

Автор: Bao Tran

Принадлежит: Individual

A heart monitoring system for a person includes one or more wireless nodes forming a wireless network; a wearable body sensor having a wireless transceiver adapted to communicate with the one or more wireless nodes.

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Номер записи: 76

04-07-2013 дата публикации

SWALLOWABLE CAPSULE FOR MONITORING A CONDITION

Номер: US20130172694A1

Автор: SHIMIZU Jeff, ZOU Hans

Принадлежит:

A swallowable capsule () is provided with a drug reservoir () and at least one sensor (). The drug reservoir () is arranged to hold a pharmaceutical composite. A wall () of the drug reservoir () comprises at least one opening for allowing fluid from the surroundings of the capsule () to enter the drug reservoir () and for allowing dissolved drug or liberated particles of the pharmaceutical composite to enter the surroundings of the capsule (). The at least one sensor () is provided for monitoring a condition of the surroundings of the capsule (). 110. A swallowable capsule () , comprising:{'b': 18', '12', '10', '18', '10, 'a drug reservoir () for holding a pharmaceutical composite, with a wall () comprising at least one opening for allowing fluid from the surroundings of the capsule () to enter the drug reservoir () and for allowing dissolved drug or liberated particles of the pharmaceutical composite to enter the surroundings of the capsule (), and'}{'b': 13', '10, 'at least one sensor () for monitoring a condition of the surroundings of the capsule ().'}210181018. A swallowable capsule () as claimed in claim 1 , wherein the drug reservoir () can be opened or detached from the capsule () in order to allow placement of the pharmaceutical composite in the reservoir ().310181212. A swallowable capsule () as claimed in claim 1 , wherein the drug reservoir () comprises a meshed wall () claim 1 , the meshed wall () comprising the at least one opening.41012. A swallowable capsule () as claimed in claim 3 , wherein the meshed wall () is injection molded.51012. A swallowable capsule () as claimed in claim 3 , wherein the meshed wall () comprises meshed metal wires.61013. As swallowable capsule () as claimed in claim 1 , wherein the sensor () is capable of providing time-stamped data.7101513. A swallowable capsule () as claimed in claim 1 , further comprising a transmitter () coupled to the sensor () for transmitting sensor information regarding the monitored condition to an ...

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Номер записи: 77

04-07-2013 дата публикации

DEVICES AND METHODS FOR BODY FLUID SAMPLING AND ANALYSIS

Номер: US20130172698A1

Автор: Bloom Daniel R., Escutia Raul, Hu Charles, Larkin John F., Reynolds Paul D., Tomasco Michael F., Vivolo Joseph A., Wiard Richard M.

Принадлежит: Intuity Medical, Inc.

Described here are meters and methods for sampling, transporting, and/or analyzing a fluid sample. The meters may include a meter housing and a cartridge. In some instances, the meter may include a tower which may engage one or more portions of a cartridge. The meter housing may include an imaging system, which may or may not be included in the tower. The cartridge may include one or more sampling arrangements, which may be configured to collect a fluid sample from a sampling site. A sampling arrangement may include a skin-penetration member, a hub, and a quantification member. 1. An integrated body fluid sampling meter comprising:a meter housing comprising a light source and a first detector; anda disposable cartridge insertable into the meter housing and comprising a plurality of cells, wherein each cell has a first wall comprising a viewing window and a second wall comprising a light-blocking covering,wherein one of the plurality of cells is positionable between the light source and the first detector.2. The meter of wherein the disposable cartridge is rotatable within the meter housing.3. The meter of wherein the meter is configured to initiate an indexing protocol upon insertion of the disposable cartridge into the meter housing claim 2 , wherein the integrity of each cell is checked.4. The meter of further comprising a processor claim 3 , and wherein the processor is configured to index each cell as either available or used during the indexing protocol.5. The meter of wherein the meter housing comprises a contact pad and wherein the disposable cartridge is movable between a testing position claim 4 , where an available cell is aligned with the contact pad claim 4 , and a standby position claim 4 , where each of the plurality of cells is out of alignment with the contact pad.6. The meter of wherein the light-blocking covering is a foil seal.7. The meter of wherein the meter housing comprises a punch for puncturing the foil seal.8. The meter of wherein the ...

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Номер записи: 78

04-07-2013 дата публикации

Multiple wavelength sensor emitters

Номер: US20130172701A1

Автор: Ammar AI-Ali, David Dalke, Marcelo Lamego, Mohamed Diab, Robert Smith

Принадлежит: Cercacor Laboratories Inc

A physiological sensor has light emitting sources, each activated by addressing at least one row and at least one column of an electrical grid. The light emitting sources are capable of transmitting light of multiple wavelengths and a detector is responsive to the transmitted light after attenuation by body tissue.

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Номер записи: 79

04-07-2013 дата публикации

Systems And Methods For Using Photoplethysmography In The Administration Of Narcotic Reversal Agents

Номер: US20130172759A1

Автор: Dennis Donn M., Melker Richard J.

Принадлежит:

Provided according to embodiments of the present invention are methods of monitoring and treating respiratory depression that include securing a photoplethysmography (PPG) sensor to a central source site of an individual; administering a central nervous system (CNS) depressant to the individual; processing PPG signals front the PPG sensor with a computer in communication with the PPG sensor; and administering a narcotic reversal agent to the individual if the PPG signals or a physiological parameter derived therefrom are outside a preset value range. Related systems are also described. 1. A method of monitoring and treating respiratory depression comprising:securing a photoplethysmography (PPG) sensor to a central source site of an individual;administering a central nervous system (CNS) depressant to the individual;processing PPG signals from the PPG sensor with a controller in communication with the PPG sensor; andadministering a narcotic reversal agent to the individual if the PPG signals or a physiological parameter derived therefrom are outside a preset value range.2. The method of claim 1 , wherein the narcotic reversal agent is administered to the individual if a respiration rate of the individual is outside the preset value range.3. The method of claim 1 , wherein the narcotic reversal agent is administered to the individual if a respiratory effort of the individual is outside the preset value range.4. The method of claim 1 , wherein the narcotic reversal agent is naloxone.5. The method of claim 1 , further comprising securing to the individual an additional sensor configured to determine at least one parameter selected from respiration rate claim 1 , end-tidal carbon dioxide content claim 1 , blood pressure claim 1 , heart rate and heart rate variability.6. The method of claim 5 , wherein the narcotic reversal agent is administered if (a) the PPG signals or a physiological parameter derived therefrom are outside a first preset value range; and (b) a ...

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Номер записи: 80

11-07-2013 дата публикации

FUNCTIONAL BRAIN IMAGING FOR DETECTING AND ASSESSING DECEPTION AND CONCEALED RECOGNITION, AND COGNITIVE/EMOTIONAL RESPONSE TO INFORMATION

Номер: US20130178733A1

Автор: Langleben Daniel D.

Принадлежит:

This invention provides method and system for measuring changes in the brain activity of an individual by functional brain imaging methods for investigative purposes, e.g., detecting and assessing whether an individual is being truthful or deceptive, and/or whether an individual has a prior knowledge of a certain face or object. The invention combines recent progress in medical brain imaging, computing and neuroscience to produce an accurate and objective method of detection of deception and concealed prior knowledge based on an automated analysis of the direct measurements of brain activity. Applying the paradigm developed from the deception model, and applying it to an individual viewing media information (e.g., audiovisual messages or movies, or announcements), the data is used to interpret the effect of the information on that individual. This permits the effective manipulation of the content of the media segments to achieve maximal desired impact in target populations or on specific individuals. 1. A computer-implemented method to objectively determine if an individual is providing a deceptive response to an inquiry , comprising:a. obtaining functional magnetic resonance image (fMRI) data of at least one cortical portion of the individual's brain in response to a test inquiry to acquire structural data reflecting at least one parameter of regional neuronal activity in the cortical portion(s) of the individual's brain, wherein the cortical portion of the individual's brain is selected from the group consisting of a left lateral prefrontal cortex, anterior cingulated cortex, orbitofrontal cortex, premotor cortex, parietal cortex, left medial frontal gyri, right medial frontal gyri, bilateral superior frontal gyri, and left orbital gyri, wherein the parameter(s) optionally is(are) increased cerebral blood flow and/or a change in proportion of oxygenated hemoglobin associated with increased metabolic activity of brain cells within such portion(s) of the individual' ...

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Номер записи: 81

18-07-2013 дата публикации

Monitoring system for sudden infant death syndrome for blind and deaf parents

Номер: US20130181833A1

Автор: Salah Abdullah Al-Ali

Принадлежит: Individual

A monitoring system for sudden infant death syndrome alerts parents, including parents who are blind and deaf, of changes in their infant's health condition. The system comprises three parts: a portable monitoring and warning control unit, a sensor bracelet that would be placed around the infant's wrist and an alarm bracelet for blind and deaf parents. The infant sensor bracelet comprises multiple sensors and a microphone and transceiver to receive and transmit data to a portable control monitoring unit. A similar system is provided for blind and deaf parents. The vibration alarm units each have Braille characters printed in the top to enable a blind person to identify the vibration alarm. A portable monitoring and warning control unit comprises at least a transceiver to communicate with the bracelets and a processing control unit to collect data and compare it with thresholds/acceptable ranges.

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Номер записи: 82

18-07-2013 дата публикации

Sensor Arrangement for Detecting Muscle Activity for the Control of Technical Equipment

Номер: US20130184539A1

Автор: Klaus Buchenrieder, Stefan Herrmann

Принадлежит: RSL STEEPER GROUP Ltd

A sensor arrangement for detecting muscle activity for the control of technical equipment. When in use the arrangement covers a region of the skin surface of a user, to provide a signal indicative of muscle activity in a limited region for subsequent processing. The arrangement has at least one double-differential myoelectric sensor, together with at least one near-infrared sensor. These are for simultaneous or time-delayed derivation of (a) myoelectric activity and (b) the value of a parameter of the blood (for example the blood oxygen content or the relative quantity of haemoglobin) respectively, in the muscle, the muscles or the tissue under the arrangement.

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Номер записи: 83

18-07-2013 дата публикации

Method and System for Providing an Integrated Analyte Sensor Insertion Device and Data Processing Unit

Номер: US20130184542A1

Автор: Stafford Gary Ashley

Принадлежит: ABBOTT DIABETES CARE INC.

Method and apparatus for providing an integrated analyte sensor and data processing unit assembly is provided. 1. An apparatus , comprising: a housing;', 'a data processing unit disposed in the housing;', 'an introducer disposed within the housing and including a first portion having a sharp distal end configured for piercing through a skin layer, wherein the first portion of the introducer is retained within the housing after piercing through the skin layer; and', wherein the first portion of the analyte sensor is configured for transcutaneous placement so as to be in fluid contact with an interstitial fluid;', 'wherein the second portion of the analyte sensor is in electrical contact with the data processing unit prior to transcutaneous placement of the first portion of the analyte sensor; and', 'wherein the housing, the data processing unit and the introducer are assembled to form the disposable assembly, and the data processing unit includes an aperture through which the introducer is removable., 'an analyte sensor including a first portion and a second portion, the first portion of the analyte sensor coupled to the first portion of the introducer, and the second portion of the analyte sensor coupled to the data processing unit;'}], 'a disposable assembly including2. The apparatus of further including an adhesive layer provided on a lower surface of the data processing unit claim 1 , wherein the adhesive layer is configured to removably attach the housing to the skin surface.3. The apparatus of claim 2 , wherein the adhesive layer includes a removable protective layer.4. The apparatus of wherein the first portion of the introducer includes a sharp tip for piercing through the skin layer claim 1 , wherein when the sharp tip is pierced through the skin layer claim 1 , the first portion of the analyte sensor is transcutaneously placed under the skin layer and in fluid contact with the interstitial fluid.5. The apparatus of wherein the introducer is configured to ...

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Номер записи: 84

25-07-2013 дата публикации

Scanning Optoacoustic Imaging System with High Resolution and Improved Signal Collection Efficiency

Номер: US20130190594A1

Автор: Conjusteau Andre, Oraevsky Alexander A., Tsyboulski Dmitri

Принадлежит:

Provided herein are scanning, high-resolution optoacoustic imaging systems or microscopes. Generally, the system/microscope comprises subsystems for scanning a tissue or object therein with a wavelength of electromagnetic energy, such as optical energy, collecting and detecting ultrasonic waves produced when the tissue or object absorbs the incident wavelength and converting the same to an electrical signal, and for processing, analyzing and displaying the electrical signal as a digital image. Specifically, the system/microscope utilizes an off-axis parabolic reflector with a high numerical aperture value for deep tissue visualization. Also, provided is a method for collecting volumetric image data voxel-by-voxel within a subject utilizing the imaging system or microscope. A series of voxels within the scanned tissue produces detectable ultrasonic waves that are collected by the off-axis parabolic reflector and processed as described as a high-resolution image of the tissue or object therein. 1. A scanning three dimensional optoacoustic imaging system , comprising:a) an electromagnetic energy delivery subsystem having a source of electronmagnetic energy deliverable to an object of interest in a subject;b) an ultrasound collection subsystem comprising an off-axis parabolic reflector disposed in a focusable relationship with a voxel of the object of interest that received the electromagnetic energy, said voxel generating detectable ultrasonic waves;c) an ultrasound detection subsystem comprising at least one ultrawide-band ultrasonic transducer configured to convert the detectable ultrasonic waves to an electrical signal;d) a scanning subsystem disposed in movable relationship to the ultrasound collection subsystem and ultrasound detection subsystem;e) an electronic subsystem comprising analog amplification, analog-to-digital conversion and digital signal processing components configured for acquisition and digital conversion of the electrical signals; andf) a ...

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Номер записи: 85

01-08-2013 дата публикации

SYSTEMS AND METHODS USING BIOMARKER PANEL DATA

Номер: US20130196870A1

Автор: Meyer Timothy E., Seth Milan, Spinale Francis G., Stolen Craig M., Wold Nicholas David

Принадлежит:

Embodiments of the disclosure are related to systems and methods for utilizing biomarker panel data and related medical devices and methods, amongst other things. An embodiment can include a method of screening patients. The method can include quantifying levels of one or more of a panel of biomarkers in a biological sample of a patient. The method can further include analyzing the quantified levels. In some embodiments, the panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4. In an embodiment, the disclosure can include a method of diagnosing a patient. The method can include quantifying levels of one or more of a panel of biomarkers in a biological sample of a patient. The method can further include diagnosing the patient based at least in part on the quantified levels. In some embodiments, the panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4. Other embodiments are also included herein. 1. A method of screening patients:quantifying levels of one or more of a panel of biomarkers in a biological sample of a patient; andanalyzing the quantified levels;wherein the panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4.2. The method of claim 1 , wherein analyzing the quantified levels includes determining whether the patient is at risk for experiencing heart failure decompensation.3. The method of claim 1 , wherein analyzing the quantified levels includes determining whether the patient is at risk for rapid decline in clinical symptoms of heart failure.4. The method of claim 1 , wherein analyzing the quantified levels includes determining whether the patient is at risk for adverse ventricular remodeling.5. The method of claim 1 , ...

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Номер записи: 86

01-08-2013 дата публикации

Flexible Electrode for Detecting Changes in Temperature, Humidity, and Sodium Ion Concentration in Sweat

Номер: US20130197319A1

Автор: Blasdel Nathaniel Jacob, Monty Chelsea N., Wujcik Evan K.

Принадлежит: THE UNIVERSITY OF AKRON

The present invention includes a flexible sensor suitable for contact with skin comprising: a nanocomposite; and a top layer; where the sensor provides in-situ detection in sweat or other aqueous body fluids at the skin surface of at least one physiological parameter selected from the group consisting of a physiological salt component, temperature, moisture, humidity, or combinations thereof. The present invention further includes a method of fabricating a flexible sensor suitable for contact with skin comprising: electrospinning at least one polyamide-producing monomer to form a non-conductive polyamide substrate; attaching at least one plurality of conductive nanoscale attachments, wherein the nanoscale attachments are selected from nanotubes, nanoparticles, or combinations thereof, to form an intermediate layer; and functionalizing the intermediate layer to form a top layer. 2. The flexible sensor of where the nanocomposite further comprises a substrate and an intermediate layer.3. The flexible sensor of claim 2 , where the substrate is non-conductive.4. The flexible sensor of claim 2 , where the substrate is a polyamide.5. The flexible sensor of claim 4 , where the polyamide is nylon-6.6. The flexible sensor of claim 2 , where the substrate is a fabric claim 2 , scrim claim 2 , sock claim 2 , mat claim 2 , scaffold claim 2 , or textile.7. The flexible sensor of claim 2 , where the substrate is formed by electrospinning.8. The flexible sensor of claim 2 , where the intermediate layer is conductive.9. The flexible sensor of claim 2 , where the intermediate layer is ceramic.10. The flexible sensor of claim 2 , where the intermediate layer is carbon.11. The flexible sensor of claim 2 , where the intermediate layer is graphene.12. The flexible sensor of claim 2 , where the intermediate layer comprises nanoparticles claim 2 , nanofibers claim 2 , nanotubes claim 2 , or combinations thereof.13. The flexible sensor of claim 11 , where the nanotubes are multi-walled ...

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Номер записи: 87

01-08-2013 дата публикации

ULTRASONIC DIGITAL COMMUNICATION OF BIOLOGICAL PARAMETERS

Номер: US20130197320A1

Автор: Albert David E., Barnett Kim Norman, Lewis James J., Satchwell Bruce Richard

Принадлежит:

Medical sensing devices and systems that transmit digital data from a first device via an ultrasonic digital modem to a receiver such as a smartphone. Methods of transmitting digital biological data by ultrasound are also described. 1. A medical sensing device for detecting a biological parameter , determining a digital representation of the biological parameter , and ultrasonically transmitting the digital representation of the biological parameters as an inaudible sound transmission , the device comprising:a sensor for detecting a biological parameter from a subject;a processor configured to receive the biological parameter, determine a representative value from the biological parameter, and digitally encode the representative value as a digital ultrasound signal, wherein the digital ultrasound signal is encoded using a first frequency corresponding to digital zero and a second frequency corresponding to digital 1, wherein the first and second frequencies are each greater than 17 kHz, further wherein the digital ultrasound signal includes a header portion and a data portion; andan ultrasonic transducer comprising an ultrasound emitter for transmitting the digital ultrasound signal, wherein the processor is configured to drive the ultrasonic transducer to emit the digital ultrasound signal from the ultrasound emitter.2. The device of claim 1 , wherein the sensor is configured to detect one or more of:temperature, glucose, pulse oxygenation, or blood pressure.3. The device of claim 1 , wherein there processor is a microprocessor.4. The device of claim 1 , wherein the first frequency is approximately 18.5 kHz and the second frequency is approximately 19.5 kHz.5. The device of claim 1 , wherein the processor is configured to digitally encode the digital ultrasound signal at 10 cycles per bit.6. The device of claim 1 , wherein the processor is configured to digitally encode the digital ultrasound signal at 200 bytes/second.7. The device of claim 1 , wherein the ...

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Номер записи: 88

01-08-2013 дата публикации

Compositions And Methods For Measurement of Analytes

Номер: US20130197326A1

Автор: CLARK Heather A., DUBACH John Matthew, Gleason Karen K., OZAYDIN-INCE Gozde

Принадлежит: NORTHEASTERN UNIVERSITY

Disclosed herein are compositions comprising an oblong optode sensing agent. The oblong optode sensing agent comprises a core and a semipermeable membrane, wherein the core comprises one or more sensors configured to bind to an analyte. In addition, methods of making and detecting the oblong optode sensing agents are disclosed. 1. An oblong optode sensing agent , the oblong optode sensing agent comprising a core and a semipermeable membrane , wherein the core comprises one or more sensors configured to bind to an analyte.2. The optode sensing agent of claim 1 , wherein the one or more sensors covalently bind to the analyte.3. The optode sensing agent of claim 1 , wherein the one or more sensors are fluorescent sensors.4. The optode sensing agent of claim 2 , wherein the analyte is selected from the group consisting of electrolytes claim 2 , salts claim 2 , hormones claim 2 , steroids claim 2 , small molecules claim 2 , drugs claim 2 , and saccharides.5. The optode sensing agent of claim 1 , wherein the core further comprises a polymer.6. The optode sensing agent of claim 1 , wherein the semipermeable membrane comprises a hydrogel.7. The optode sensing agent of claim 5 , wherein the semipermeable membrane comprises a biocompatible hydrogel.8. The optode sensing agent of claim 1 , wherein the semipermeable membrane is permeable to analyte and impermeable to the one or more sensors.9. The optode sensing agent of claim 5 , wherein the core comprises one or more polymers selected from the group consisting of polyvinyl chloride claim 5 , polylactic co-glycolic acid claim 5 , methacrylate claim 5 , and polycaprolactone10. The optode sensing agent of claim 1 , wherein the optode sensing agent has a circular cross-section.11. The optode sensing agent of claim 1 , wherein the optode sensing agent has a rectangular shape.12. The optode sensing agent of claim 10 , wherein the optode sensing agent has a length of about 40 μm to about 60 μm.13. The optode sensing agent of claim ...

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Номер записи: 89

01-08-2013 дата публикации

TISSUE IMPLANTABLE SENSOR WITH HERMETICALLY SEALED HOUSING

Номер: US20130197332A1

Автор: Catlin Mark B., Choi William J., Chu Payton C., Lin Joe T., Lucisano Joseph Y., Routh Timothy L., Wallner Thomas G.

Принадлежит:

A tissue-implantable sensor for measurement of solutes in fluids and gases, such as oxygen and glucose, is provided. The sensor includes: i) a detector array including at least one detector; ii) a telemetry transmission portal; iii) an electrical power source; and iv) circuitry electrically connected to the detector array including signal processing means for determining an analyte level, such as glucose level, in a body fluid contacting the detectors. The sensor components are disposed in a hermetically sealed housing having a size and shape suitable for comfortable, safe, and unobtrusive subcutaneous implantation allowing for in vivo detection and long term monitoring of tissue glucose concentrations by wireless telemetry. 1. An implantable analyte sensor , comprising:a) a biocompatible hermetically sealed housing having a size and shape suitable for implantation in the body;b) a detector array comprising at least one detector and a membrane layer;c) an electrical power source;d) circuitry operatively connected to the detector array comprising functionality for accurately processing detector signals; ande) a telemetry transmission portal for stably transmitting processed detector signals to an external receiver outside of a body when implanted subcutaneously,wherein c) and d) are disposed within the housing and b) and e) are disposed within or upon the housing.2. The sensor of claim 1 , wherein the detector array comprises at least two detectors.3. The sensor of claim 2 , wherein the detector array comprises between two and eighteen detectors.4. The sensor of claim 2 , wherein the detectors are arranged in a radial pattern.5. The sensor of claim 2 , wherein the detectors comprise electrochemical detectors that utilize at least one counter electrode.6. The sensor of claim 5 , wherein the electrolyte layers of at least two of the detectors have no common aqueous or ionic connection.7. The sensor of claim 6 , wherein the at least two of the detectors utilize separate ...

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Номер записи: 90

01-08-2013 дата публикации

BIODETECTOR

Номер: US20130197334A1

Автор: Niestroj Robert, Weber Ekkehardt

Принадлежит: GILUPI GMBH

The invention concerns a Biodetector with a functionalised surface for isolating molecules or cells from the human body. In order to improve a Biodetector of the type mentioned above such that the functionalised surface of the Biodetector or there upon enriched molecules or cells are exposed to a lower abrasion, and the biocompatibility of the Biodetector is improved, the Biodetector is designed to remove a fluid from the human body and absorb it into an inner space of the Biodetector, wherein the functionalised surface is oriented to the inner space of the Biodetector. 1. Biodetector with comprising:a functionalised surface for isolation of molecules or cells from a human body, wherein the Biodetector is configured to remove a fluid from the human body, and to absorb it into an inner space of the Biodetector, wherein the functionalised surface is oriented to the inner space of the Biodetector.2. Biodetector according to claim 1 , wherein the functionalised surface is at least partially occupied with detection molecules.3. Biodetector according to claim 2 , wherein the detection molecule includes antibodies claim 2 , selected from a group consisting of monoclonal antibodies claim 2 , chimeric antibodies claim 2 , humanized antibodies claim 2 , antibody fragments or amino acid structures and amino acid sequences claim 2 , nucleic acid structures and nucleic acid sequences claim 2 , carbohydrate structures claim 2 , and synthetic structures.4. Biodetector according to claim 2 , wherein the detection molecules are of non-human origin.5. Biodetector according to claim 1 , wherein the detection molecules are connected and oriented to the functionalised surface.6. Biodetector according to claim 1 , wherein the detection molecules are covalently attached to the functionalised surface.7. Biodetector according to claim 1 , wherein the Biodetector has a fluid removable section claim 1 , which satisfies at least one of the following requirements:a. The fluid removal section ...

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Номер записи: 91

01-08-2013 дата публикации

Heart Age Assessment

Номер: US20130197374A1

Автор: Cobain Mark Robert

Принадлежит: CONOPCO, INC., D/B/A UNILEVER

An automated method of determining a measure of a subject's heart age comprising the steps of: prompting a user for a plurality of inputs, each relating to an attribute of the subject, each attribute defining one or more of a demographic status of the subject, a lifestyle status of the subject, a physical condition of the subject and a medical history of the subject; receiving, from the user, a plurality of said inputs; determining from said received inputs, a set of parameters for which input data has been received as input from the user; selecting a heart age calculation algorithm from a predetermined set of heart age calculation algorithms according to said set of parameters; and calculating a heart age for the subject according to the selected algorithm; and providing as output said calculated heart age. 122-. (canceled)23. An automated method of estimating blood lipid levels of a subject , said method carried out on a computer system and comprising the automated steps of:a) receiving a plurality of data values, each relating to an attribute of the subject, each attribute defining one or more of a demographic status of the subject, a lifestyle status of the subject, a physical condition of the subject and a medical history of the subject, the data values not including any quantitative measure of a cholesterol level of the subject, said data values either provided by the user through a user input device of the computer system or transferred electronically from another device;b) calculating a CVD risk for the subject based on said data values using a first algorithm stored in a database on the computer system;c) determining one or a range of possible total cholesterol levels and HDL cholesterol levels for the subject consistent with the calculated first CVD risk by comparison of the first CVD risk with statistical average CVD risk as a function of measured total and HDL cholesterol levels in a population;d) determining a statistical average total cholesterol level ...

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Номер записи: 92

08-08-2013 дата публикации

SENSORS FOR DETECTING SUBSTANCES IN BODILY FLUIDS

Номер: US20130202721A1

Автор: Silver James H.

Принадлежит:

A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed. 1. An apparatus for measuring nitrite in blood of a human or animal subject , the apparatus comprising:a housing, at least a portion of which is configured for placement in a blood vessel of the subject;a size-exclusion filter within the housing, configured to allow nitrite ions to pass through the filter and impede passage of particles having a molecular weight greater than about 60 kD through the filter;a nitrite reduction agent within the housing, configured to reduce nitrite ions to nitric oxide; anda nitric oxide electrode within the housing for measuring nitric oxide.2. The apparatus of claim 1 , wherein the housing comprises a needle configured for advancement into a blood vessel of the subject.3. The apparatus of claim 1 , wherein the filter is configured to allow nitrite molecules to pass through the filter.4. The apparatus of claim 1 , wherein the filter is configured to exclude hemoglobin and erythrocytes.5. The apparatus of claim 1 , further comprising a vacuum source coupled with the housing claim 1 , configured to improve flux through the filter.6. The apparatus of claim 1 , wherein the filter comprises a membrane comprising a material selected from the group consisting of polycarbonate claim 1 , polysulfone claim 1 , polyethersulfone claim 1 , polyarylethersulfone claim 1 , polyurethane claim 1 , polyacrylonitrile claim 1 , regenerated cellulose claim 1 , mixed cellulose ester claim 1 , polyester claim 1 , Nylon claim 1 , poly(vinylidene ...

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Номер записи: 93

08-08-2013 дата публикации

PATIENT SUPPORTING DEVICE, TREATMENT APPARATUS WITH A PATIENT SUPPORTING DEVICE AND CORRESPONDING METHOD FOR CONTROLLING AND/OR REGULATING A MEDICAL TREATMENT DEVICE

Номер: US20130204098A1

Автор: Chamney Paul, MOISSL Ulrich, Wabel Peter, Wieskotten Sebastian

Принадлежит: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH

The subject matter is a patient supporting device for supporting a patient during a medical treatment, in particular a dialysis treatment, and a treatment apparatus with such a patient supporting device, and a corresponding method for controlling and/or regulating a medical treatment device, in particular a dialysis device, using such a patient supporting device. 1. Patient supporting device for supporting a patient [ ["a device for coupling a measurement signal into the patient's body and", "a device for coupling an electrical measurement value thereby generated in the patient's body out of the patient's body,"], 'wherein this apparatus comprises'}, 'wherein via this interface the data correlated with the electrical measurement value can be transmitted to the medical treatment device, by means of which the medical treatment device can be controlled and/or regulated.', 'and an interface for connecting to a medical treatment device,'}], "with an apparatus for carrying out a bioimpedance measurement on a patient's body,"}2. Patient supporting device according to claim 1 , characterized in thatthe medical treatment device is a dialysis device.3. Patient supporting device according to claim 1 , characterized in thatthe apparatus for carrying out a bioimpedance measurement comprises a device for determining the patient's weight.4. Patient supporting device according to claim 1 , characterized in that the apparatus for carrying out a bioimpedance measurement comprises at least two electrodes for contacting the patient's body for coupling the measurement signal into the patient's body (=coupling-in electrodes) claim 1 , preferably by impressing a measurement current into the patient's body claim 1 , andat least two electrodes for contacting the patient's body for coupling the electrical measurement value generated by the measurement signal in the patient's body out of the patient's body (=coupling-out electrodes), preferably by capturing a change in potential generated by ...

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Номер записи: 94

08-08-2013 дата публикации

WIRELESS ELECTRODE ARRANGEMENT AND METHOD FOR PATIENT MONITORING VIA ELECTROCARDIOGRAPHY

Номер: US20130204100A1

Автор: Acquista Angelo Joseph

Принадлежит: Wireless Live D/B/A Peerbridge Health

A system including a plurality of wireless sensors for monitoring one or more parameters of a subject is provided. The wireless sensors can be attachable to or implantable in the subject and form a network. The sensors can include a sensing component configured to detect a signal corresponding to at least one condition of the subject. The sensors further can include a communication component configured to wirelessly transmit the detected signal to at least another of the plurality of wireless sensors, and wirelessly receive a signal transmitted from at least one of the remaining sensors in the network. 1. A system for monitoring one or more hemodynamic parameters of a subject , comprising: a sensing component configured to detect a signal corresponding to at least one hemodynamic condition of the subject;', wirelessly transmit the detected signal to at least one of the plurality of wireless sensors, and', 'wirelessly receive a signal transmitted from at least one of the remaining sensors in the network., 'a communication component configured to], 'a plurality of wireless sensors attachable to or implantable in the subject and forming a network, each sensor comprising2. The system of claim 1 , wherein the network is a mesh network.3. The system of claim 1 , wherein the hemodynamic parameters include one or more of pulse oximetry claim 1 , oxygen saturation claim 1 , oxyhemoglobin saturation claim 1 , blood glucose level claim 1 , blood pressure claim 1 , blood velocity claim 1 , blood flow rate claim 1 , respiratory rate claim 1 , pulse rate claim 1 , COlevel claim 1 , drug concentration claim 1 , blood protein concentration claim 1 , heart rate claim 1 , heart rhythm claim 1 , heart rate variability claim 1 , organic or inorganic substance concentration claim 1 , cardiac activity claim 1 , cardiac output claim 1 , pH levels claim 1 , pathogens and galvanic skin response.4. The system of claim 1 , wherein each of the plurality of wireless sensors further comprises:a ...

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Номер записи: 95

15-08-2013 дата публикации

CONFIGURABLE PATIENT MONITORING SYSTEM

Номер: US20130211214A1

Автор: Olsen Gregory A.

Принадлежит: CERCACOR LABORATORIES, INC.

A patient monitoring system can display one or more configurable health monitors on a configurable user interface. The health indicators are configured to display a physiological signal from a patient. The patient monitoring system can calculate ranges of values for the health indicator that correspond to a status of the patient. The health indicators can display different outputs based on the value of the physiological signal. 1. A patient monitoring system , comprising:at least one physiological sensor including a first and second light emitter and a detector, wherein the physiological sensor is configured to measure at least one physiological signal from a patient;at least one health indicator, wherein the health indicator is configured to display a signal value based upon the at least one physiological signal; receive patient information;', 'calculate a first range of values for the at least one health indicator based at least in part on the patient information, wherein the first range of values corresponds to a first range of physiological signals from the patient, wherein the first range of values corresponds to a first patient condition;', 'calculate a second range of values for the at least one health indicator based at least in part on the patient information, wherein the second range of values corresponds to a second range of physiological signals from the patient, wherein the second range of values corresponds to an second patient condition; and, 'a processorwherein the at least one health indicator is configured to display a first output when the signal value is within the first range of values; andwherein the at least one health indicator is configured to display a second output when the signal value is within the second range of values.2. The patient monitoring system of claim 1 , wherein the first patient condition is a healthy condition.3. The patient monitoring system of claim 1 , wherein the first patient condition is an unhealthy condition.4. The ...

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Номер записи: 96

15-08-2013 дата публикации

ENDOSCOPE SYSTEM, PROCESSOR DEVICE THEREOF, AND IMAGE PRODUCING METHOD

Номер: US20130211217A1

Автор: IIDA Takayuki, SAITO Takaaki, Yamaguchi Hiroshi

Принадлежит: FUJIFILM Corporation

First and second white light is generated by excitations of phosphors with first and second laser beams having center wavelengths of 473 nm and 445 nm, respectively. The first and second white light is applied, in respective frames, sequentially to a region of interest in a subject. A color image sensor images the region of interest in the each frame. Based on a shift amount, calculated from green signals of first and second frames, between images, an image of a blue signal of the first frame is moved to be aligned with an image of a green signal and an image of a red signal of the second frame. After the alignment, an oxygen saturation image representing an oxygen saturation level of hemoglobin in blood is produced from the blue signal of the first frame and green and red signals of the second frame, and displayed on a display. 1. An endoscope system comprising:a lighting section for applying at least first illumination light and second illumination, light, in respective frames, to a region of interest, a wavelength range of the first illumination light being different from a wavelength range of the second illumination light, the region of interest including a blood vessel;an image signal acquisition section having a color image sensor with an array of pixels of at least three primary colors, the image signal acquisition section imaging the region of interest in the each frame, the image signal acquisition section imaging the region of interest illuminated with the first illumination light to acquire three color signals of a first frame, the image signal acquisition section imaging the region of interest illuminated with the second illumination light to acquire three color signals of a second frame;a shift amount calculator for calculating a shift amount between an image of the first frame and an image of the second frame based on the color signals of same color;a registration section for aligning images of predetermined color signals, used for calculating an ...

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Номер записи: 97

15-08-2013 дата публикации

Method and System for Differential Diagnosis of Chronic Schizophrenia and Chronic Alcoholism

Номер: US20130211227A1

Автор: Panchalingam Kenagasabai, Pettegrew Jay W.

Принадлежит:

Biomarker diagnosis of chronic schizophrenia in the presence of cognitive impairment is confirmed when Phosphocreatine (PCr) levels are increased, compared to normal levels, in both the left and right prefrontal cortices of the brain, with increased PCr specifically also in the left basal ganglia and also reduced NA/Crin the left superior temporal region of the brain. Biomarker differential diagnosis is also taught for chronic alcoholism (with or without cognitive impairment) and for chronic schizophrenia even when cognitive impairment is absent. 1. A method for the differential diagnosis of chronic schizophrenia or chronic alcoholism , comprising imaging the brain of a subject in need of diagnosis for the markers PCr , NA/Cr , and sPDE and determining any increase or decrease in the presence of said markers compared to normal levels in specified anatomic areas of the brain , and outputting the results of the imaging as one or more files or images to be viewed by a user.2. The method according to claim 1 , wherein after quantifying PCr claim 1 , NA/Crand sPDE claim 1 , a determination that (1) PCr levels are increased claim 1 , compared to normal levels claim 1 , in both the left and right prefrontal cortices of the brain claim 1 , together with increased (2) PCr specifically also in the left basal ganglia and also (3) reduced NA/Crin the left superior temporal region of the brain claim 1 , together confirm a differential diagnosis of chronic schizophrenia when cognitive impairment is present.3. The method according to claim 1 , wherein after quantifying PCr claim 1 , NA/Crand sPDE claim 1 , a determination that (1) phosphocreatine (PCr) levels are increased in the right basal ganglia claim 1 , with (2) reduced NA/Crin all three of: (a) the left basal ganglia; (b) the right occipital cortex; and (c) the left centrum semiovale claim 1 , together with (3) reduced sPDE in the right inferior parietal and the right centrum semiovale claim 1 , together confirm a ...

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Номер записи: 98

15-08-2013 дата публикации

REFLECTION-DETECTOR SENSOR POSITION INDICATOR

Номер: US20130211264A1

Автор: Lamego Marcelo

Принадлежит: MASIMO CORPORATION

A reflection-detector sensor position indicator comprises emitters that transmit light having a plurality of wavelengths. A detector outputs a sensor signal. At least one reflection detector outputs at least one sensor position signal. An attachment assembly attaches the emitters, the detector and the reflection detector onto a tissue site. A sensor-on condition indicates that the attachment assembly has positioned the emitters generally centered over a fingernail, the detector on a fingertip opposite the fingernail and the reflection detector over the fingernail. The sensor signal, in the sensor-on condition, is at least substantially responsive to the emitter transmitted light after attenuation by pulsatile blood flow perfused within a fingernail bed underneath the fingernail. The sensor position signal, in the sensor-on condition, is at least substantially responsive to the emitter transmitted light after reflection off of the fingernail. 1. An optical sensor configured to provide an indication of a physiological parameter comprising:a plurality of emitters that transmit light having a plurality of wavelengths;a detector that outputs a sensor signal, the sensor signal is at least substantially responsive to the emitter transmitted light after attenuation by pulsatile blood flow perfused within a fingernail bed underneath the fingernail; andat least one reflection detector that outputs at least one sensor position signal, the sensor position signal including a sensor-on condition indicating that the attachment assembly has positioned the emitters generally centered over a fingernail, the detector on a fingertip opposite the fingernail and the at least one reflection detector over the fingernail, the at least one sensor position signal, in the sensor-on condition, is at least substantially responsive to the emitter transmitted light after reflection off of the fingernail.an attachment assembly that attaches the emitters, the detector and the at least one reflection ...

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Номер записи: 99

29-08-2013 дата публикации

IMPLANTABLE MEDICAL DEVICE

Номер: US20130225947A1

Автор: Blomqvist Andreas

Принадлежит: ST. JUDE MEDICAL AB

An implantable medical device comprising a coronary perfusion measurement unit is adapted to measure and determine parameters related to coronary perfusion of heart tissue. The parameters include time periods and perfusion magnitudes. The coronary perfusion measurement unit is configured to determine a time period T related to a perfusion event of a coronary vessel and including includes a reperfusion time period, where a perfusion event is defined as a decrease of coronary perfusion followed by reperfusion, and to generate a time period signal in dependence thereto. The implantable medical device further comprises a coronary flow calculation unit that is adapted to receive the time period signal and that is adapted to process the time period and to generate an ischemia risk indicating index I in dependence of the time period. 1. An implantable medical device comprising:a coronary perfusion measurement unit adapted to measure and determine parameters related to coronary perfusion of heart tissue, the parameters including time periods and perfusion magnitudes, wherein the coronary perfusion measurement unit is configured to determine a time period T related to a perfusion event of a coronary vessel and includes a reperfusion time period, wherein the perfusion event is defined as a decrease of coronary perfusion followed by reperfusion, and wherein the coronary perfusion measurement unit is configured to generate a time period signal in dependence thereto; anda coronary flow calculation unit adapted to receive the time period signal and adapted to process the time period and generate an ischemia risk indicating index I in dependence of the time period.2. The implantable medical device according to claim 1 , wherein the time period T is determined as the time period that starts when the perfusion magnitude is at its minimum and ends when the perfusion magnitude is back to an initial perfusion level.3. The implantable medical device according to claim 1 , wherein the ...

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Номер записи: 100