НЕИНВАЗИВНОЕ ИЗМЕРЕНИЕ УРОВНЯ БИЛИРУБИНА В КОЖЕ

Изобретение касается способа и устройства для неинвазивного измерения составных элементов ткани, в частности уровня билирубина кожи. Устройство содержит считывающую головку, выполненную с возможностью последовательного излучения нескольких вспышек с различными определенными длинами волн в направлении анализируемой ткани и измерения отраженного света, вычислительное устройство, такое как микропроцессор, выполненное с возможностью вычисления для каждой длины волны количества отраженного света и его приведения к значению, рассчитанному пропорционально идентичному контрольному значению для определенной контрольной длины волны, и компаратор, позволяющий сравнить рассчитанное таким образом значение с таблицей контрольных значений. Изобретение обеспечивает качественный и количественный анализ уровня билирубина в коже без использования сложной аппаратуры. 2 н. и 8 з.п. ф-лы, 7 ил.

МОНИТОРИНГ ТРЕВОЖНОСТИ

Группа изобретений относится к медицинской технике, а именно к средствам мониторинга пациента с уровнем тревожности. Система мониторинга пациента содержит сенсорный модуль, выполненный с возможностью получения данных о пациенте и содержащий пробу на кортизол в слюне для измерения его уровня в слюне или в крови, модуль оценки состояния тревожности пациента по первичным данным и уточненной оценки состояния тревожности пациента на основании дополнительных данных, причем модуль оценки дополнительно выполнен с возможностью определения состояния тревожности пациента на основании уровня кортизола в слюне или уровня кортизола в крови, и модуль индикатора передачи определенного состояния тревожности медицинскому персоналу по обратной связи. Способ мониторинга пациента обеспечивается при работе системы мониторинга. Использование изобретений позволяет расширить арсенал средств мониторинга пациентов с уровнем тревожности. 2 н. и 8 з.п. ф-лы, 2 ил.

УСТРОЙСТВО ДЛЯ НАБЛЮДЕНИЯ, ЗОНД ДЛЯ ИССЛЕДОВАНИЯ И СИСТЕМА НАБЛЮДЕНИЯ

Группа изобретений относится к медицине, а именно к наблюдению за физиологическими параметрами в живом организме. Предложена система, содержащая устройство, причем система содержит первый терминал; устройство для наблюдения; и зонд для исследования физиологических параметров в живом организме, содержащий: щуп для исследования, выполненный с возможностью приема собранного сигнала; соединитель, один конец которого присоединен к щупу для исследования посредством первого провода, а другой конец соединителя имеет второй стык, выполненный с возможностью съемного присоединения к первому стыку устройства для наблюдения; и второй модуль хранения, выполненный с возможностью сохранения идентификатора зонда для исследования и заданного порогового значения, при этом второй модуль хранения представляет собой интегральную схему памяти, при этом щуп для исследования содержит датчик для сбора собранного сигнала, и второй модуль хранения расположен в щупе для исследования, или в соединителе, или между щупом ...

БИОЛОГИЧЕСКИЙ КОНТРОЛЬ В ЭЛЕКТРОННЫХ КУРИТЕЛЬНЫХ ИЗДЕЛИЯХ

Группа изобретений относится к медицинской технике и предназначена для биологического контроля в электронных курительных изделиях. Курительное изделие включает корпус, содержащий мундштук и выполненный с возможностью размещения субстрата, генерирующего никотиносодержащий аэрозоль. Управляющая электроника выполнена с возможностью управления доставкой определенного количества никотиносодержащего аэрозоля из субстрата, генерирующего никотиносодержащий аэрозоль, через мундштук. Курительное изделие дополнительно содержит датчик метаболитов никотина, расположенный в мундштуке и функционально соединенный с управляющей электроникой. Датчик расположен так, что, когда курящий контактирует губами с мундштуком, датчик может обнаружить определенные количество или концентрацию метаболита никотина в слюне курящего. Раскрыта курительная система, использующая курительное изделие и субстрат, генерирующий никотинсодержащий аэрозоль. Изобретения обеспечивают данные, касающиеся количества метаболита никотина ...

УСТРОЙСТВО, СИСТЕМА И СПОСОБ ДЛЯ МОДУЛЬНОГО КОНТРОЛЯ АНАЛИЗИРУЕМОГО ВЕЩЕСТВА

Группа изобретений относится к медицине. Система содержит одноразовый корпус, имеющий отверстие, одноразовые электрические контакты, прокалывающий кожу элемент, измерительный элемент для измерения концентрации анализируемого вещества и соединительный механизм для крепления указанного одноразового корпуса в области прокола; и многоразовый корпус, имеющий многоразовые электрические контакты, источник питания, контроллер, приемопередатчик и механический привод. При соединении многоразового корпуса с одноразовым корпусом происходит электрическое соединение соответствующих многоразовых электрических контактов с одноразовыми электрическими контактами. Механический привод соединен с прокалывающим кожу элементом и измерительным элементом и управляет ими. Контроллер сконфигурирован так, чтобы при приеме сигнала запуска заставлять механический привод прокалывать кожу через указанное отверстие посредством прокалывающего кожу элемента в области прокола, заставлять механический привод перемещать измерительный ...

СТРОБИРОВАННАЯ АМПЕРОМЕТРИЯ

Изобретение относится к области электрохимических методов анализа. Предложена система датчика, устройство и способы для определения концентрации анализируемого вещества в образце. Последовательности стробированных амперометрических импульсов, включающие в себя многочисленные рабочие циклы последовательных возбуждений и релаксаций, обеспечивают более короткое время анализа и/или улучшают точность и/или воспроизводимость анализа. Раскрытые последовательности стробированных амперометрических импульсов могут снижать погрешности анализа, являющиеся результатом гематокритного эффекта, изменения объемов цокольного зазора, неустановившихся режимов, медиаторного фона, недозаполнения, изменений температуры в образце и одиночного набора калибровочных констант. 6 н. и 24 з.п. ф-лы, 3 табл., 11 ил.

НАТЕЛЬНОЕ ИЗМЕРИТЕЛЬНОЕ УСТРОЙСТВО

Нательное измерительное устройство для инвазивного измерения концентрации аналита, в частности глюкозы, относится к медицинской технике. Устройство содержит сенсор для чрескожной установки в ткани пациента, опорную пластину для установки на коже пациента, блок электроники. Сенсор для чрескожной установки в ткани пациента содержит рабочий электрод, противоэлектрод и электрод сравнения. Сенсор выступает из клейкой поверхности опорной пластины. Блок электроники содержит микроконтроллер и токоизмерительный узел. Микроконтроллер имеет управляющий выход, первый аналоговый вход и второй аналоговый вход. Управляющий выход функционально связан с управляющим электродом. Управляющим электродом является рабочий электрод или противоэлектрод. Первый аналоговый вход функционально связан через токоизмерительный узел с измерительным электродом. Измерительным электродом является рабочий электрод или противоэлектрод. Второй аналоговый вход функционально связан с электродом сравнения. Микроконтроллер выполнен ...

НОСИМОЕ НА ТЕЛЕ МЕДИЦИНСКОЕ УСТРОЙСТВО

Группа изобретений относится к медицине. Носимое на теле медицинское устройство, такое как система для мониторирования аналита в физиологической жидкости или устанавливаемый на пластыре насос для введения лекарственного средства в организм пользователя, содержит самоклеящийся гибкий электронный пластырь, приклеиваемый к коже пользователя, способный деформироваться, следуя контуру кожи, и содержит гибкую печатную схему, нанесенную непосредственно на пленочную подложку. Причем носимое на теле медицинское устройство содержит интерфейс пользователя, позволяющий пользователю управлять устройством, а пленочная подложка способна растягиваться по меньшей мере в одном направлении более чем на 20% ее первоначальной длины. Причем передача данных между гибкой печатной схемой и интерфейсом пользователя обеспечивается проводящим текстилем. Способ управления носимым на теле медицинским устройством включает следующие шаги: i) приклеивание к коже пользователя самоклеящегося гибкого электронного пластыря ...

УСТРОЙСТВО ОПРЕДЕЛЕНИЯ СВОЙСТВА ТКАНИ

... 1. Устройство определения свойства ткани для совместной работы с оптическим измерительным устройством для определения свойства ткани, причем ткань (6) содержит эпителий (15) и строму (14) и оптическое измерительное устройство (2) содержит:- блок (2, 7, 8, 9) обеспечения света для обеспечения света (11, 12, 13), освещающего ткань (6), и- блок (4, 10) обнаружения света для обнаружения света (11, 12, 13) от ткани (6), в котором блок (3, 7, 8, 9) обеспечения света и блок (4, 10) обнаружения света выполнены с возможностью формирования первого сигнала, индицирующего свет (11), вызванный влиянием области (R1) эпителия ткани (6), содержащей эпителий (15), второго сигнала, индицирующего свет (12), вызванный влиянием граничной области (R2) ткани (6), содержащей границу между эпителием (15) и стромой (14), и третьего сигнала, индицирующего свет (13), вызванный влиянием области (R3) стромы ткани (6), содержащей строму (14),в котором устройство (16) определения свойства ткани выполнено с возможностью ...

АКТИВНАЯ ДОСТАВКА ЛЕКАРСТВЕННОГО СРЕДСТВА В ЖЕЛУДОЧНО-КИШЕЧНОМ ТРАКТЕ

... 1. Устройство для введения лекарственного средства, включающее принимаемую внутрь капсулу, которая содержит:лекарственное средство, содержащееся в капсуле;чувствительный к окружающей среде механизм, выполненный таким образом, чтобы изменять свое состояние в ответ на положение капсулы в желудочно-кишечном (ЖК) тракте пациента;первый и второй электроды; иуправляющий элемент, выполненный таким образом, чтобы в ответ на изменение состояния чувствительного к окружающей среде механизма облегчать прохождение лекарственного средства через эпителиальный слой ЖК тракта, путем обеспечения подачи первым и вторым электродами серии импульсов с силой тока менее чем приблизительно 10 мА, частотой от 10 до 100 Гц и длительностью импульса от приблизительно 0,5 мс до приблизительно 3 мс.2. Устройство по п.1, отличающееся тем, что ток включает ток силой менее чем приблизительно 7 мА, и тем, что управляющий элемент выполнен таким образом, чтобы обеспечивать подачу первым и вторым электродами серии импульсов ...

УСТРОЙСТВО ДЛЯ ДОМАШНЕГО МОНИТОРИНГА ГЕМАТОЛОГИЧЕСКИХ ПАРАМЕТРОВ ПАЦИЕНТОВ

... 1. Устройство (100) для домашнего мониторинга гематологических параметров пациентов, причем устройство содержит:- счетчик (101) лейкоцитов,- пользовательский интерфейс (102),причем счетчик лейкоцитов выполнен с возможностью приема образцовой пробы крови для определения значения лейкоцитов в принятой образцовой пробе,причем пользовательский интерфейс физически отделен или физически отделим от счетчика лейкоцитов, ипричем пользовательский интерфейс выполнен с возможностью отображения информации, основанной на значении лейкоцитов в принятой образцовой пробе крови, как определено счетчиком (101) лейкоцитов.2. Устройство по п. 1, дополнительно содержащее:- термометр (103), выполненный с возможностью определения значения температуры тела пациента,причем термометр и пользовательский интерфейс выполнены с возможностью предоставления определенного значения температуры тела на пользовательский интерфейс.3. Устройство по п. 2,причем термометр содержит интерфейс, в частности интерфейс Bluetooth, для ...

ИНТЕГРИРОВАННЫЙ ИЗМЕРИТЕЛЬ ДЛЯ ТЕСТИРОВАНИЯ ОБРАЗЦА

... 1. Интегрированный тестирующий образец измеритель, содержащий один модульный корпус, включающий в себя средство прокола, набор элементов привода для ввода в действие средства прокола между выдвинутым положением и отведенным назад положением, картридж с тестирующими полосками, содержащий множество тестирующих полосок, причем каждая полоска имеет принимающую образец область, датчик для анализа образца жидкости, принятого на тестирующую полоску, и устройство подачи тестирующей полоски для выдвижения тестирующих полосок отдельно из картриджа в принимающее образец положение, в котором тестирующая полоска соединена с датчиком, причем измеритель выполнен так, что при использовании, когда он располагается в первом положении на коже пользователя и активирован, средство прокола выполнено с возможностью движения в его выдвинутое положение и отвода назад для образования прокола в коже пользователя, а тестирующая полоска способна выдвигаться из картриджа в принимающее образец положение. 2. Измеритель ...

МЕДИЦИНСКОЕ УСТРОЙСТВО ДЛЯ ЧРЕСКОЖНОГО ВВЕДЕНИЯ ВВОДИМОГО ЭЛЕМЕНТА В ТКАНЬ ОРГАНИЗМА

СИСТЕМА И СПОСОБ ОПРЕДЕЛЕНИЯ КОЛИЧЕСТВЕННОГО ПОКАЗАТЕЛЯ РИСКА ГЕМОДИНАМИЧЕСКОЙ НЕСТАБИЛЬНОСТИ У ПЕДИАТРИЧЕСКИХ СУБЪЕКТОВ

БИОМЕДИЦИНСКИЕ УСТРОЙСТВА ДЛЯ ПЕРЕДАЧИ БИОМЕТРИЧЕСКОЙ ИНФОРМАЦИИ С ВОЗМОЖНОСТЬЮ ОБРАТНОЙ СВЯЗИ

УСТРОЙСТВО ДЛЯ ЛЕЧЕНИЯ ИНДИВИДУУМА СО СНИЖЕННОЙ ФУНКЦИЕЙ СЕРДЦА, ОСТАНОВКОЙ СЕРДЦА, ОСТАНОВКОЙ КРОВООБРАЩЕНИЯ ИЛИ АПОПЛЕКСИЧЕСКИМ УДАРОМ

... 1. Устройство для лечения индивидуума с остановкой сердца или кровообращения или с апоплексическим ударом, содержащее применяемое на индивидууме (Р) средство (ВЕ) взятия крови для взятия по меньшей мере части крови у индивидуума, блок (ВА) анализа, опосредованно или непосредственно связанный со средством взятия крови, для определения и предоставления по меньшей мере одной характеристики крови в виде результата (ВАЕ) анализа крови, исполнительный блок (КЕ), который опосредованно или непосредственно связан с применяемым на индивидууме средством (BR) обратной подачи и выполненный с возможностью передачи вещества индивидууму через средство (BR) обратной подачи, отличающееся тем, что исполнительный блок (КЕ) содержит по меньшей мере один блок (R) резервуара, который создает запас по меньшей мере двух веществ (S, S, …), что предусмотрен скомбинированный с блоком (R) резервуара блок (D) дозирования, который по меньшей мере с учетом результата (ВАЕ) анализа крови, определенного блоком (ВА) анализа ...

СПОСОБ ДЛЯ НЕИНВАЗИВНОГО АНАЛИЗА КОНЦЕНТРАЦИИ ВЕЩЕСТВА В ТЕЛЕ

... 1. Способ для неинвазивного измерения концентрации вещества в теле, содержащий:изменение температуры поверхности тела от одной температуры до второй температуры;затем восстановление первой температуры посредством изменения температуры поверхности тела от второй температуры до первой температуры;измерение первой дозы инфракрасного излучения, поглощаемого или испускаемого телом в первом диапазоне длин волн в заданных интервалах времени во время восстановительного изменения поверхности тела от второй температуры до первой температуры;измерение второй дозы инфракрасного излучения, поглощаемого или испускаемого телом во втором диапазоне длин волн в заданных интервалах времени во время восстановительного изменения поверхности тела от второй температуры до первой температуры;измерение температуры на поверхности тела;измерение температуры окружающей среды;вычисление нормированного параметра отношения на основании первой дозы, второй дозы, температуры поверхности тела и температуры окружающей среды ...

ОБНАРУЖЕНИЕ ИНФЕКЦИИ ПРИ ТЕРАПИИ РАН ПОНИЖЕННЫМ ДАВЛЕНИЕМ

... 1. Способ обнаружения инфекции в ране, вызванной заражающим организмом на участке раны, включающий: ! сбор текучей среды из участка раны, выведенной в ответ на пониженное давление, приложенное к участку раны, и ! осуществление анализа текучей среды, собранной из участка раны, для выявления продукта инфекции, ! причем наличие продукта инфекции указывает на наличие инфекции в ране. ! 2. Способ по п.1, в котором рана содержит ткань, выбранную из группы, состоящей из кожной ткани, костной ткани, хрящей, сухожилий, связок, мышц, нервной ткани, подкожной ткани и жировой ткани. ! 3. Способ по п.1, в котором продукт инфекции представляет собой аденозин-5'-трифосфат (АТФ). ! 4. Способ по п.3, в котором объединяют текучую среду, собранную из участка раны, с люциферазой и люциферином для получения реакции и затем измеряют свет, создаваемый реакцией, для обнаружения АТФ, причем рана является инфицированной, если создаваемый свет выше уровня, создаваемого текучей средой, собранной из раны, которая не ...

МИКРОЧИП И УСТРОЙСТВО ДЛЯ МОНИТОРИНГА КРОВИ

... 1. Микрочип, включающий в себя: ! первый канал, который обеспечивает возможность поступления первой жидкости, выбранной из цельной крови, обогащенной тромбоцитами плазмы, и жидкости из них, обработанных лекарственным средством; ! второй канал, соединенный с первым каналом, который обеспечивает возможность поступления второй жидкости, содержащей реагент, который является реакционноспособным по отношению к указанной первой жидкости; и ! объединенный канал, проходящий от участка соединения первого канала со вторым каналом, ! при этом в указанном объединенном канале предусмотрена секция перемешивания, имеющая перемешивающий якорек для смешения первой жидкости со второй жидкостью. ! 2. Микрочип по п.1, в котором поверхность указанного перемешивающего якорька была подвергнута обработке для ингибирования свертывания крови. ! 3. Микрочип по п.2, в котором указанная обработка для ингибирования свертывания крови представляет собой обработку, в результате которой по меньшей мере поверхность перемешивающего ...

МИКРОЭЛЕКТРОДЫ В ОФТАЛЬМИЧЕСКОМ ЭЛЕКТРОХИМИЧЕСКОМ ДАТЧИКЕ

... 1. Устанавливаемое на глазу устройство, содержащее:прозрачный полимерный материал, имеющий вогнутую поверхность и выпуклую поверхность, причем вогнутая поверхность выполнена съемно устанавливаемой поверх роговичной поверхности, а выпуклая поверхность выполнена совместимой с движением век, когда вогнутая поверхность установлена таким образом;подложку, по меньшей мере частично заделанную внутри полимерного материала;антенну, расположенную на подложке;двухэлектродный электрохимический датчик, расположенный на подложке и включающий в себя:рабочий электрод, имеющий по меньшей мере один размер менее чем 25 микрометров; иэлектрод сравнения, имеющий по меньшей мере в пять раз большую площадь, чем площадь рабочего электрода; иконтроллер, электрически соединенный с электрохимическим датчиком и антенной, причем контроллер выполнен с возможностью: (i) прикладывания напряжения между рабочим электродом и электродом сравнения, достаточного для генерации амперометрического тока, связанного с концентрацией ...

Способ оценки тяжести состояния новорожденных

Изобретение относится к области медицины, а именно к неонатологии, и может быть использовано для оценки степени тяжести состояния новорожденных. Проводят оценку центральной нервной системы, дыхательной системы, сердечно-сосудистой системы, температуры тела, отличающийся тем, что дополнительно оценивают наличие или отсутствие кислородной зависимости, уровня рН и лактата в капиллярной крови. Полученным показателям присваивают баллы от 0 до 2, затем баллы суммируют. И при сумме баллов от 1 до 2 стояние новорожденного оценивают как средней степени тяжести, при сумме баллов от 3 до 8 стояние новорожденного оценивают как тяжелой степени тяжести, при сумме баллов от 9 до 14 стояние новорожденного оценивают как крайне тяжелой степени тяжести. Способ позволяет объективно оценить тяжесть состояния и органной дисфункции у новорожденных и своевременно проводить профилактические мероприятия, что позволит улучшить показатели здоровья и качества жизни таких детей за счет оценки совокупности наиболее значимых ...

An identification system and combined analysis unit comprises using biometric data to provide identification and health analysis of a driver in a road vehicle

An identification system [3] that is connected to an analysis system [2] comprises using biometric information that is generated by an iris scanner or fingerprint scanner, where in addition to identification, the system uses a blood sample or hair sample to provide a health test.

VORRICHTUNG UND VERFAHREN ZUR NICHTINVASIVEN MENGENBESTIMMUNG VON IM BLUT ODER GEWEBE VORLIEGENDEN BESTANDTEILEN

Analysevorrichtung

Eine Analysevorrichtung gemäß einer Ausführungsform der vorliegenden Erfindung umfasst: eine Lichtquellenvorrichtung; einen Bildsensor, der durch Aufnehmen eines Bilds von durch von der Lichtquellenvorrichtung erzeugtes Licht beleuchtetem biologischem Gewebe Farbbilddaten erzeugt; eine Einheit zur Berechnung eines Indikators, die auf der Grundlage der Farbbilddaten einen Indikator X berechnet, der eine Eigenschaftsgröße Q des biologischen Gewebes aufzeigt, und eine Einheit zur Ermittlung einer Eigenschaftsgröße, die auf der Grundlage des Indikators X die Eigenschaftsgröße Q ermittelt. Die Einheit zur Ermittlung einer Eigenschaftsgröße umfasst eine Beitragsberechnungseinheit, die auf der Grundlage von mindestens zwei Farben unter in den Farbbilddaten enthaltenen Einzelfarbbilddaten einen Beitrag C, den Beitrag C der Streuung in einer spektralen Kennlinie des biologischen Gewebes, berechnet. Ebenso ermittelt die Einheit zur Ermittlung einer Eigenschaftsgröße auf der Grundlage des Indikators ...

SYSTEM FÜR DIE PROBENAHME UND ANALYSE IN VIVO

System und Verfahren zum Untersuchen eines Objekts

Verfahren zum Untersuchen eines eine strömende Flüssigkeit enthaltenden Objekts, umfassend: Beleuchten des Objekts mit Meßlicht und Aufnehmen wenigstens einer Sequenz von ersten Bildern des beleuchteten Objekts, wobei eine Belichtungsdauer für eine jede Aufnahme eines Bildes der Sequenz von ersten Bildern kleiner als 1 ms, insbesondere kleiner als 0,1 ms und weiter insbesondere kleiner als 0,03 ms, ist; Auswerten der wenigstens einen Sequenz von ersten Bildern (k = 1, ..., N), indem Pixeln (i, j) in der Sequenz von ersten Bildern (Ik(i, j)), auf die gleiche Orte (x, y) des Objekts abgebildet werden, jeweils ein erster Analysebildwert zugeordnet wird, welcher von zeitlichen Änderungen von Bildwerten (I(t, i, j)) der Pixel (i, j) in der wenigstens einen Sequenz von ersten Bildern (Ik(i, j)) in einem Frequenzbereich oberhalb 1 kHz, insbesondere oberhalb 10 kHz, abhängt, gekennzeichnet durch Auswerten der wenigstens einen Sequenz von ersten Bildern (k = 1, ..., N), indem ferner Pixeln (i, j ...

GERÄT UND VERFAHREN ZUR NICHTINVASIVEN MESSUNG VON BLUTBESTANDTEILEN

Querempfindlichkeitskompensierter Biosensor

Die Erfindung betrifft einen Biosensor (10), insbesondere einen implantierbaren Biosensor, mit einem für wenigstens einen Analyten sensiblen Sensormaterial (60), insbesondere mit einem für wenigstens einen Analyten sensiblen Hydrogel, in einem mit einem Drucksensor (56) gekoppelten Druckmessraum (20), wobei ein im Druckmessraum (20) herrschender Druck durch den Drucksensor (56) bestimmbar ist. Das Sensormaterial (60) ist im Druckmessraum (20) mit einem Kompensationsmaterial (70) gekoppelt, welches einen Zusammenhang zwischen der Temperatur und dem Volumen bzw. dem Druck aufweist, der die temperaturabhängige Druck- bzw. Volumenänderung des Sensormaterials (60) entgegengesetzt ist und eine temperaturbedingte Volumenänderung zumindest teilweise kompensiert.

TRAGBARES SENSORSYSTEM MIT MESSPFLASTER

Die Erfindung betrifft ein tragbares System (S) zur Messung und Überwachung physiologischer Parameter eines Menschen mittels Analyse einer seiner Körperflüssigkeiten, wobei das System (S) folgendes umfasst:- ein Verbrauchsteil (100) in Form eines Messpflasters zum Aufkleben auf die Haut (E), wobei das Messpflaster mit Sensorik (102) ausgestattet ist, die dazu eingerichtet ist, durch Körperflüssigkeitsanalyse Messwerte physiologischer Parameter zu liefern; und- eine am Körper tragbare und zum Dauereinsatz geeignete Ausleseeinheit (200), die dazu eingerichtet ist, die von der Sensorik (102) des Messpflasters gelieferten Messwerte auszulesen und zu überwachen. Die Ausleseeinheit (200) ist ferner dazu eingerichtet, über dem auf der Haut (E) aufgeklebten Messpflaster (100) getragen zu werden und in dieser Position die Messwerte auszulesen und zu überwachen.

Flexible light sources and detectors and applications thereof

Method and device for noninvasive measurement of concentrations of blood components

Method for monitoring of blood components

Foetal blood sampling probe

Fluid sampling apparatus and method

Electrochemical and luminescent sensor structures integrated on common substrate

MICROWAVE APPARATUS AND METHOD FOR MEASURING CONSTITUENT CONCENTRATIONS WITHIN BIOLOGICAL TISSUE

Apparatus for minimally invasively measuring concentrations of constituents contained within a biological tissue structure (80) includes a microwave energy source (10) arranged generate a range of microwave frequencies, a first antenna (70) coupled to the microwave energy source and arranged to transmit at least a portion of the microwave energy into the tissue structure, a second antenna (71) arranged to receive at least a portion of the microwave energy transmitted through the tissue structure, a signal processor (110) arranged to determine the resonant frequency of the received microwave energy, and a data processor arranged to provide an output of the concentration of constituents within the biological tissue according to the determined resonant frequency.

A gum shield configured to detect concussion

A medical device for measuring a concentration of an entity in a digit

A device 700 to measure the concentration of a blood parameter (e.g. glucose) includes a housing into which the digit of a user is received, a non-invasive blood parameter concentration sensor (e.g. optical 727, electromagnetic 725) and a pressure sensor 725 to measure pressure applied by the digit onto the concentration sensor. The housing has a hinge 722, base 720 and lid 721, and the device adjusts the pressure applied to the sensor by the finger dependent on the measured pressure. Blood glucose readings may be taken when the applied finger pressure is within a predetermined range, thus increasing measurement reliability. Alternatively or additionally to using finger pressure measurement, the device may control the volume of blood in the finger using a tourniquet 710, and determine digit orientation for example using a fingerprint sensor 726 (see figs 8-10). Measurements may be suspended until the finger is positioned correctly or an adjustment made to a measurement taken at an incorrect ...

Patches for reverse iontophoresis

Aspirators

An in-line tester 10 comprising a chamber 14 having an inlet 16 for connection to a nasogastric (NG) tube, an outlet 20 for connection to an aspirator and a porous/perforated element 48 separating the inlet from the outlet. The porous/perforated element 48 provided on one side with a liquid-absorbent layer 50 comprising a calorimetric substance adapted to exhibit a colour change in the presence of a target substance indicative of those commonly found in the stomach. The porous/perforated element is also provided on its other side with a hydrophobic layer 52 which, when dry, permits the passage of gases therethrough, but when wetted, prevents their passage. A capnometer 64 is also provided between the porous/perforated element 48 and the outlet 20. In use, air is aspirated into the chamber 14 and its CO2 concentration measured, with the results providing an indication as to whether the air originated in the lungs or the stomach. Liquid is then aspirated into the chamber 14. Given that the ...

Analyte Detection apparatus and method of detecting an analyte

An analyte detection apparatus comprises a radiation source (8, fig 2) for irradiating a sample such as the skin (11, fig 2); and a receiver 10, to receive an optical Raman spectrum of radiation transmitted back from the sample (11, fig 2) in response to the received radiation from the source (8, fig 2). The receiver 10 comprises a plurality of different types of analysis device 181-4 each arranged to receive a selected part of the received optical spectrum transmitted back from the sample (11, fig 2). There may be filtration elements 141-4 to split the energy in dependence on frequency or wavelength and direct selected parts of the spectrum 161-4 to the desired analysis device 18, such that more data may be derived from the most important parts of the spectrum. The analysis devices 18 may include CCD-based and CMOS-based spectrometers, and may have different levels of resolution or signal-to-noise ratio. The apparatus may be used to determine the concentration of an analyte in the blood ...

A monitoring device

A monitoring device comprises monitoring unit 2 having electroanalytical component (3, Fig. 1) and electrical contact 11, and sensor unit 4 (advantageously disposable) having sensor arrangement (5, Fig. 1) and electrical contact (12, Fig. 3). The monitoring unit 2 and sensor unit 4 are held together releasably, and in electrical communication, by a cooperating attachment arrangement, perhaps base plate (8, Fig 2c) and clip mechanism (9, 10, Fig. 2c). The monitoring unit may have casing 6, maybe sealed, comprising recess 7 with walls 20 and 21 having no sharp internal angles; advantageously, this facilitates easy cleaning. Battery charging unit (17, Fig. 5) may instead be inserted into the recess to charge an internal battery via contact 16. The sensor unit may have flow cell(s) (26, Fig. 1) and fluid input and output (22, 23, Fig. 1). The sensor arrangement may comprise electrochemical or optical sensors, and a recognition substrate (enzyme, antibody etc) which binds to the analyte.

Device

An analyte monitoring device 2 for use in contact with the skin 4 comprises a porous membrane 6 comprising an enzyme. Preferably glucose or lactate are detected via a reaction using glucose oxidase or lactate dehydrogenase to yield hydrogen peroxide which is subsequently detected using an electrode 8. Preferably the porous membrane is polyethersulfone or nylon 6, 6 such as Biodyne A or C membrane. Preferably the membrane forms a three dimensional matrix of enzyme having a thickness of less than 300 µm and the average pore size is around 0.3 µm to 0.5 µm. Preferably use of the device is preceded by an additional step such as iontophoresis, ultrasound or microneedle microporation. Methods of use of the device to continuously monitor an analyte such as glucose are disclosed.

Wearable diagnostic device

A device and methods for in vivo monitoring of an individual

A device and methods for in vivo monitoring of an individual

SELECTIVE EXPOSITION OF MINIATURE PROBES WITH INTEGRATED SENSOR ARRAYS FOR CONTINUOUS IN-VIVO DIAGNOSIS

USE OF ULTRAVIOLET, CLOSE-ULTRAVIOLET AND NAHINFRAROT RESONANZRMANSPEKTROSKOPIE ONES AND FLUORESENZSPEKTOSKOPIE FOR FABRIC INVESTIGATION ON SHOCK CONDITION, CRITICAL DISEASES OR OTHER DISEASE CONDITIONS

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

IMPLANTIERBARE AND RE+WITHDRAWABLE SENSOR DEVICE

PROCEDURE FOR THE SEPARATION OF MONOUND MULTIPLE LAYERS OF ORGANOPHOSPHORUND - PHOSPHONIC ACIDS AND THEIR SALTS AS WELL AS THEIR USE

FROM HETERO-CYCLIC NITROGEN ATOMS ABSTENTIONS POLYMERS COMPOSITION BIO SENSOR DIAPHRAGMS

IN VIVO SENSOR MEASUREMENT OF OSMOTIC CHANGES

EQUIPMENT FOR THE MEASUREMENT OF A ANALYTEN IN A BODY FLUID

SYSTEMS AND - PROCEDURES WITH COMBINED INTERNAL TOTAL REFLECTION AND FABRIC ILLUSTRATION

DEVICE AND PROCEDURE FOR NICHTINVASIVEN THE MEASUREMENT OF A LIVING BODY

IMPLANTIERBARES MULTIPLE PARAMETER PERCEPTION SYSTEM AND PROCEDURE

MULTISPEKTRALBIOMETRIESENSOR

MEDICINE PRODUCT FOR THE ANALYTENÜBERWACHUNG AND DRUG DELIVERY

SMALL-VOLUMED SENSOR TO IN-VITRO REGULATION

PROCEDURE AND EQUIPMENT FOR THE SAMPLING AND ANALYSIS OF INTERSTITIAL LIQUID AND FULL BLOOD

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

USE OF ULTRAVIOLET, CLOSE-ULTRAVIOLET AND NAHINFRAROT RESONANZRMANSPEKTROSKOPIE ONES AND FLUORESENZSPEKTOSKOPIE FOR FABRIC INVESTIGATION ON SHOCK CONDITION, CRITICAL DISEASES OR OTHER DISEASE CONDITIONS

USE OF ULTRAVIOLET, CLOSE-ULTRAVIOLET AND NAHINFRAROT RESONANZRMANSPEKTROSKOPIE ONES AND FLUORESENZSPEKTOSKOPIE FOR FABRIC INVESTIGATION ON SHOCK CONDITION, CRITICAL DISEASES OR OTHER DISEASE CONDITIONS

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

USE OF ULTRAVIOLET, CLOSE-ULTRAVIOLET AND NAHINFRAROT RESONANZRMANSPEKTROSKOPIE ONES AND FLUORESENZSPEKTOSKOPIE FOR FABRIC INVESTIGATION ON SHOCK CONDITION, CRITICAL DISEASES OR OTHER DISEASE CONDITIONS

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

USE OF ULTRAVIOLET, CLOSE-ULTRAVIOLET AND NAHINFRAROT RESONANZRMANSPEKTROSKOPIE ONES AND FLUORESENZSPEKTOSKOPIE FOR FABRIC INVESTIGATION ON SHOCK CONDITION, CRITICAL DISEASES OR OTHER DISEASE CONDITIONS

USE OF ULTRAVIOLET, CLOSE-ULTRAVIOLET AND NAHINFRAROT RESONANZRMANSPEKTROSKOPIE ONES AND FLUORESENZSPEKTOSKOPIE FOR FABRIC INVESTIGATION ON SHOCK CONDITION, CRITICAL DISEASES OR OTHER DISEASE CONDITIONS

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

USE OF ULTRAVIOLET, CLOSE-ULTRAVIOLET AND NAHINFRAROT RESONANZRMANSPEKTROSKOPIE ONES AND FLUORESENZSPEKTOSKOPIE FOR FABRIC INVESTIGATION ON SHOCK CONDITION, CRITICAL DISEASES OR OTHER DISEASE CONDITIONS

USE OF ULTRAVIOLET, CLOSE-ULTRAVIOLET AND NAHINFRAROT RESONANZRMANSPEKTROSKOPIE ONES AND FLUORESENZSPEKTOSKOPIE FOR FABRIC INVESTIGATION ON SHOCK CONDITION, CRITICAL DISEASES OR OTHER DISEASE CONDITIONS

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

USE OF ULTRAVIOLET, CLOSE-ULTRAVIOLET AND NAHINFRAROT RESONANZRMANSPEKTROSKOPIE ONES AND FLUORESENZSPEKTOSKOPIE FOR FABRIC INVESTIGATION ON SHOCK CONDITION, CRITICAL DISEASES OR OTHER DISEASE CONDITIONS

USE OF ULTRAVIOLET, CLOSE-ULTRAVIOLET AND NAHINFRAROT RESONANZRMANSPEKTROSKOPIE ONES AND FLUORESENZSPEKTOSKOPIE FOR FABRIC INVESTIGATION ON SHOCK CONDITION, CRITICAL DISEASES OR OTHER DISEASE CONDITIONS

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

EQUIPMENT FOR THE DETERMINATION OF THE DIALYSIS EFFICIENCY

USE OF ULTRAVIOLET, CLOSE-ULTRAVIOLET AND NAHINFRAROT RESONANZRMANSPEKTROSKOPIE ONES AND FLUORESENZSPEKTOSKOPIE FOR FABRIC INVESTIGATION ON SHOCK CONDITION, CRITICAL DISEASES OR OTHER DISEASE CONDITIONS

Analyte test instrument system including data management system

Methods of identifying schizophrenia patients at risk for relapse

The invention provides methods of identifying schizophrenia patients at risk for relapse. The invention also provides methods of early detection of schizophrenic relapse. The disclosed methods use symptom monitoring according to a subset of Positive and Negative Syndrome Scale (PNASS) parameters. The methods of the invention can be used to provide early intervention to decrease or prevent relapse in schizophrenia patients.

System and method for providing alerts optimized for a user

Systems and methods are disclosed that provide smart alerts to users, e.g., alerts to users about diabetic states that are only provided when it makes sense to do so, e.g., when the system can predict or estimate that the user is not already cognitively aware of their current condition, e.g., particularly where the current condition is a diabetic state warranting attention. In this way, the alert or alarm is personalized and made particularly effective for that user. Such systems and methods still alert the user when action is necessary, e.g., a bolus or temporary basal rate change, or provide a response to a missed bolus or a need for correction, but do not alert when action is unnecessary, e.g., if the user is already estimated or predicted to be cognitively aware of the diabetic state warranting attention, or if corrective action was already taken.

Optimizing organic growth using spectrial measurement

A system for measuring a market performance metric of an animal comprising: a sensor unit that detects an emitted spectrum from the animal wherein the sensor unit filters the received emitted spectra to a set of spectral values; and a memory unit that comprises a set of predetermined chemometric data correlated to at least the market performance metric, wherein the memory unit is correlated to the set of spectral values.

Physiological signal monitoring device with an electrostatic-discharge protective mechanism

PHYSIOLOGICAL SIGNAL MONITORING DEVICE WITH AN ELECTROSTATIC-DISCHARGE PROTECTIVE MECHANISM A physiological signal monitoring device includes 5 a base (1) and a transmitter (3). The base (1) is provided with a biosensor (2). The transmitter (3) is removably coupled to the base (1), and includes a casing (31) and an electrostatic-discharge protective unit (39) . The casing (31) has a socket (367) for the 10 biosensor (2) to be removably inserted thereinto. The electrostatic-discharge protective unit (39) is disposed to at least surround the periphery of the socket (367) to dispel static electricity when electrostatic discharge occurs. (Fig. 2) 'II 'IM ...

Oral appliance

The present invention provides An oral appliance for detecting acceleration experienced by a head of a wearer. The mouth-guard comprises a body comprising a formation for extending around at least a portion of at least one of maxillary and mandibular teeth of a wearer and configured for location against at least a portion of at least one of maxillary and mandibular teeth at least at one of: an anterior teeth region of a mouth of the wearer; a posterior teeth region of a mouth of the wearer; and a position between the anterior and posterior teeth regions of a mouth of the wearer. The mouth-guard further comprising a system for monitoring acceleration experienced by the mouth-guard and operative to communicate acceleration data to a monitoring station, and a power source electrically coupled to the system for monitoring acceleration and for providing power thereto. The power source is embedded within material of the body and is located within a region of the body that is beatable at a posterior ...

Micro Biosensor and Method for Reducing Measurement Interference Using the Same

Micro Biosensor and Method for Reducing Measurement Interference Using the Same The present invention provides a micro biosensor for reducing a measurement interference when measuring a target analyte in the biofluid, including: a substrate; a first working electrode configured on the surface, and including a first sensing section; a second working electrode configured on the surface, and including a second sensing section which is configured adjacent to at least one side of the first sensing section; and a chemical reagent covered on at least a portion of the first sensing section for reacting with the target analyte to produce a resultant. When the first working electrode is driven by a first working voltage, the first sensing section measures a physiological signal with respect to the target analyte. When the second working electrode is driven by a second working voltage, the second conductive material can directly consume the interferant so as to continuously reduce the measurement ...

A system for determining fluid level in a biological subject

A system for performing fluid level measurements on a biological subject, the system including at least one substrate including a plurality of microstructures configured to breach a stratum corneum of the subject, at least some microstructures including an electrode, a signal generator operatively connected to at least one microstructure to apply an electrical stimulatory signal to the at least one microstructure and at least one sensor operatively connected to at least one microstructure, the at least one sensor being configured to measure electrical response signals from at least one microstructure. The system also includes one or more electronic processing devices that determine measured response signals, the response signals being at least partially indicative of a bioimpedance and perform an analysis at least in part using the measured response signals to determine at least one indicator at least partially indicative of fluid levels in the subject.

Portable diagnostic apparatus and the method thereof

A method and a portable diagnostic apparatus (20) for detecting at least one analyte from a sample using a microfluidic cartridge (22). The portable diagnostic apparatus (20) comprises a cartridge receiving unit, a cartridge driver unit (30) and an optical unit (32). A method and an apparatus of obtaining disease prevalence information comprising at least one of the portable diagnostic apparatus (20). A method and a system for managing a network of portable diagnostic apparatuses and obtaining disease prevalence information comprising at least one of the portable diagnostic apparatus (20). A diagnostic system with multiple automated features that is capable of providing a one-step solution to near-patient clinical evaluation and diagnosis.

Systems, devices and methods for sensing physiologic data and draining and analyzing bodily fluids

Abstract Systems, devices and methods for sensing physiologic data and draining and analyzing bodily fluids are described which are capable of sensing physiologic data based on sensors 5 incorporated into a catheter adapted to reside in any of a urinary tract, gastrointestinal tract, rectal location, pre-peritoneal, pleural space or other body cavity. The devices aid emptying of the bladder, measure urine output and various urine parameters such as oxygen tension, urine conductance and urine specific gravity, monitor renal function, analyze urine parameters, including urine content, including the presence of infection, and track and/or control fluid 10 administration. 16639503_1 (GHMatters) P43852AU01 ...

Methods, systems, and devices for calibration and optimization of glucose sensors and sensor output

A continuous glucose monitoring system may utilize externally sourced information regarding the physiological state and ambient environment of its user for externally calibrating sensor glucose measurements. Externally sourced factory calibration information may be utilized, where the information is generated by comparing metrics obtained from the data used to generate the sensor's glucose sensing algorithm to similar data obtained from each batch of sensors to be used with the algorithm in the future. The output sensor glucose value of a glucose sensor may also be estimated by analytically optimizing input sensor signals to accurately correct for changes in sensitivity, run-in time, glucose current dips, and other variable sensor wear effects. Correction actors, fusion algorithms, EIS, and advanced ASICs may be used to implement the foregoing, thereby achieving the goal of improved accuracy and reliability without the need for blood-glucose calibration, and providing a calibration-free ...

System and method for detecting and monitoring blast exposure using magnetic resonance spectroscopy (MRS)

A system and method identifies blast exposure by the use of magnetic resonance spectroscopy (MRS) to measure absolute and relative concentrations of metabolites in specific brain regions in the central nervous system or brain. The system and method can be used as a diagnostic tool for the assessment of blast exposure. These chemical changes in the brain of those people suffering from blast exposure are different from those suffering from head injury, chronic pain and other neurological conditions.

Systems, devices, and methods for performing trans-abdominal fetal oximetry and/or trans-abdominal fetal pulse oximetry using independent component analysis

Independent component analysis may be performed on a plurality of detected electronic signals to separate signals within the detected electronic signals that are contributed by different sources. Each of the plurality of detected electronic signals may be received from a separate detector and may correspond to a detected optical signal emanating from a pregnant mammal's abdomen and a fetus contained therein. The detected optical signals may correspond to light that is projected into the pregnant mammal's abdomen from a light source. The separated signals may be analyzed to determine a separated signal that corresponds to light incident upon the fetus, which may be analyzed to determine a fetal hemoglobin oxygen saturation level of the fetus. An indication of the fetal hemoglobin oxygen saturation level may then be provided to the user.

Systems and methods for display device and sensor electronics unit communication

SYSTEMS AND METHODS FOR DISPLAY DEVICE AND SENSOR ELECTRONICS UNIT COMMUNICATION Methods and apparatus are provided for communication among display devices and sensor electronics unit in an analyte monitoring system. The analyte monitoring system may include a sensor that is configured to perform measurements indicative of analyte levels. The sensor may be communicatively coupled to the sensor electronics unit. The sensor electronics unit may be configured to transmit data indicative of analyte levels to the display devices using one or more communication protocols. Furthermore, the sensor electronics unit may be configured to operate in multiple modes, and switch between the modes in response to commands received from the display devices. Related systems, methods, and articles of manufacture are also described.

Noninvasive blood analysis by optical probing of the veins under the tongue

Method, system and computer program product for real-time detection of sensitivity decline in analyte sensors

Biosensor coated with electroactive polymer layer demonstrating bending behavior

Disclosed is a biosensor coated with an electroactive polymer layer demonstrating a bending behavior, more specifically a biosensor including an electroactive polymer layer coated on the surface of a bioreceptor and an electrode connected to the electroactive polymer layer. When an electrical stimulation is applied to the electrode, the electroactive polymer layer shows a bending behavior and thus the surface of the bioreceptor can be exposed to an analyte to allow a concentration analysis of the analyte. When used as an implantable biosensor, the disclosed biosensor may have a substantially increased life span since the bioreceptor can be selectively exposed to the analyte.

Method for distributing contact information between applications

A method and system for distributing contacting information between applications is provided. The system preferably uses an ENUM-type protocol and a middleware tool kit to associate telephone numbers to other identifying information, such as e-mail addresses or URLs for web sites. The system enables the associated contacting information to be shared across multiple applications that may be implemented on a computer or a mobile telephony device. Information is shared only after verification that a requester is authorized to receive the requested contacting information.

Measuring Instrument for Determining the Tissue Alcohol Concentration

A measuring instrument for determining the concentration of components in the body tissue by reflection spectroscopy is disclosed. In order, inter alia, to increase the functional reliability in the case of vibrations, the measuring instrument includes a diode laser with at least one laser diode and a waveguide structure, which has an external resonator, with a wavelength selective element, for each laser diode. In the process, the radiation generated by a laser diode is coupleable into the waveguide structure and the corresponding resonator and once again decoupleable from the resonator and the waveguide structure. Moreover, a corresponding method and a motor vehicle equipped therewith are disclosed.

Electrochemical sensors

Described herein are substrates, sensors and systems related to measuring the concentration of an analyte such as hydrogen ion in a sample. Redox active moieties whose reduction and/or oxidation potentials are sensitive to the presence of an analyte are immobilized onto a surface of an electrode. Immobilized redox active moieties whose reduction and/or oxidation potential are insensitive to the analyte can be used for reference. Voltammetric measurements made using such modified surfaces can accurately determine the presence and/or concentrations of analytes in a sample of interest. The electrochemical sensors of the invention are robust and can be made so as not to require calibration or recalibration.

System and method for physiological monitoring

Apparatus, systems, and methods for monitoring a sensor module mounted in a sensor platform, wherein the sensor platform includes an adhesive side and a pocket, wherein the pocket is designed to receive the sensor module, to facilitate sensing by the sensor module of physiological attributes, and to allow insertion and removal of the sensor device from the pocket.

Analyte Monitoring Devices and Methods

Methods and devices for providing application specific integrated circuit architecture for a two electrode analyte sensor or a three electrode analyte sensor are provided. Systems and kits employing the same are also provided.

Physiological data acquisition utilizing vibrational identification

The present invention utilizes an accelerometer (included within a wireless physiology monitoring device or as part of a separate device such as, but not limited to a smartphone, e.g., iPhone, or other mobile device) to link a patient with a separate medical data acquisition device such as a weight scale or a blood pressure monitor in order to collect and transmit a range of medical data associated with the user. The medical data acquisition device includes a vibration source for emitting a vibration at a predetermined or random frequency. When the acquisition device is activated, a vibration is transmitted from the through the patient and is detected by the accelerometer. The accelerometer then measures the particular frequency of vibration and transmits this information to a centralized monitoring unit (CMU). Based on the measured frequency, the CMU is able to know that the same patient wearing/holding the device is also the same patient using the data acquisition device. The vibration source may revolve through a number of predetermined frequencies (as determined on its own or instructed via the CMU) or simply generate a random frequency.

System and method for endoluminal and translumenal therapy

A system for conducting a denervation of the neural plexus adjacent the renal artery of a patient comprises a first elongate member operatively coupled to a testing element, a second elongate member having a distal portion coupled to an ablative element, and a controller configured to: activate an ablative element to selectively denervate a portion of the neural plexus which is positioned adjacent the ablative element; monitor a level of a compound in blood sampled from the testing element of the first elongate member; and modulate the activation of the ablative element based at least in part upon the level of renin monitored using the testing element.

Apparatus and methods for monitoring physiological data during environmental interference

Apparatus and methods for attenuating environmental interference are described. A wearable monitoring apparatus includes a housing configured to be attached to the body of a subject and a sensor module that includes an energy emitter that directs energy at a target region of the subject, a detector that detects an energy response signal—or physiological condition—from the subject, a filter that removes time-varying environmental interference from the energy response signal, and at least one processor that controls operations of the energy emitter, detector, and filter.

Bodily fluid composition analyzer with disposable cassette

Disclosed is an apparatus for analyzing the composition of bodily fluid. The apparatus can include a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and a pump unit in operative engagement with the fluid handling network. The pump unit can have an infusion mode, in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode, in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus can include a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample.

Sensor Calibration

A sensor kit comprising a sensor for detecting an analyte, a sensor housing and a calibration chamber. The calibration chamber comprises a first compartment containing a first calibration solution and a second compartment containing a source of the analyte to be detected. A dividing material is located between the first and second compartments enabling them to be mixed on breakage or removal of the dividing material. Further compartment(s) containing further source(s) of the analyte may optionally be provided. Calibration can carried out by (a) taking a reading of the analyte concentration of the first calibration solution, (b) mixing the contents of the first and second compartments by breaking or removing the dividing material, and (c) taking a reading of the analyte concentration of the resulting mixture. Steps (b) and (c) can be repeated for further compartment(s) to provide further reading(s) if desired.

Transdermal systems, devices, and methods for biological analysis

A transdermal test sensor includes a test chamber including a liquid, a reagent system in contact with the liquid, a housing containing the liquid, and a semipermeable membrane. The housing includes an opening, the semipermeable membrane is connected to the housing and covers the opening, and the housing and the semipermeable membrane enclose the liquid and the reagent system. The transdermal test sensor also includes an analyzer in communication with the liquid. When porated tissue is contacted with the semipermeable membrane and sufficient time is allowed for a fluid sample to traverse the porated tissue and for an analyte in the fluid sample to enter the liquid in the transdermal sensor through the semipermeable membrane, a change in at least one optical property or at least one electrical property of the liquid is detected. The change detected is then correlated with the analyte concentration in the fluid sample.

Transdermal systems, devices, and methods to optically analyze an analyte

The invention provides transdermal optical analysis systems, test sensors, methods, and kits for determining the presence and/or concentration of at least one analyte in a fluid sample. The system includes a transdermal test sensor including an aqueous material including at least one analyte selective reagent and at least one optically active moiety. The optical system preferably uses fluorescent spectroscopy to correlate fluorescent emission or adsorption from a dye with the analyte concentration of the sample. An optical light source and/or detector may be housed with the aqueous material in a housing or external to the housing of the aqueous material.

Advanced analyte sensor calibration and error detection

Systems and methods for processing sensor data and self-calibration are provided. In some embodiments, systems and methods are provided which are capable of calibrating a continuous analyte sensor based on an initial sensitivity, and then continuously performing self-calibration without using, or with reduced use of, reference measurements. In certain embodiments, a sensitivity of the analyte sensor is determined by applying an estimative algorithm that is a function of certain parameters. Also described herein are systems and methods for determining a property of an analyte sensor using a stimulus signal. The sensor property can be used to compensate sensor data for sensitivity drift, or determine another property associated with the sensor, such as temperature, sensor membrane damage, moisture ingress in sensor electronics, and scaling factors.

Determining Analyte Concentrations in Biological Fluids with Abnormal Output Detection

A biosensor has an abnormal output detection system that determines whether an output signal from the redox reaction of an analyte has a normal or abnormal shape or configuration. The abnormal output detection system improves the accuracy and precision of the biosensor in determining whether an output signal has a shape or configuration that may not provide an accurate and/or precise analysis of a biological fluid. The biosensor generates an output signal in response to the redox reaction of the analyte. The biosensor normalizes the output signal and compares the normalized output signal with one or more control limits. The biosensor may generate an error signal when the normalized output signal is not within the control limits.

Manufacturing electrochemical sensor module

Certain processes for manufacturing an electrochemical sensor module include assembly first and second housing portions of sensor modules; dispensing a sensor fiber across multiple first housing portions; joining the first and second housing portions; and separating the sensor modules by cutting the sensor fiber.

Method for preparing a catheter assembly including a sensing element having an adhesive backing

The present invention is directed to a sensing element that comprises a flexible substrate having first and second opposite surfaces; at least one sensor disposed on the first surface of the flexible substrate; an adhesive layer substantially covering the second surface of the flexible substrate; and a release liner releasably adhered to the adhesive layer so that upon removal of the release liner the adhesive layer is exposed for securing the sensing element to the catheter. The release liner permits the sensing element to be positioned at a desired location within the catheter after which the release liner can be removed to expose the adhesive layer. The adhesive layer can then be used to attach and secure the sensing element at a desired location on the catheter. As a result, the need for additional adhesives can be reduced or eliminated.

Optical thromboelastography system and method for evaluation of blood coagulation metrics

Device, method, and computer program product for determining a material parameter of a blood coagulation cascade based on parameters of light diffused at a biofluid sample. In one example, the biofluid sample includes a blood sample. Laser light scattered by the sample is collected by the optical system in reflection and/or transmission mode. An image of the sample in so collected light is formed, and data representing fluctuations of laser speckle intensity with is processed to derive numerical descriptors associated with blood coagulation and fibrinolysis. In a specific case, such numerical descriptors are derived based on temporal dynamic of a viscoelastic characteristic of the blood sample.

Biometric healthcare data system

A biometric healthcare data system has biometric data collection stations and a network management system. Each station has several biometric data measurement devices including a bioelectrical impedance analysis system. Each station has a gateway that connects to the devices and that connects the station through the internet to the network management system. The network management system has a communications manager that tracks the stations, a content manager that provides content to the stations and a data manager that retrieves and stores data from the data collection stations.

Portable monitoring devices and methods of operating same

The present inventions, in one aspect, are directed to a portable activity monitoring device to calculate a number of stairs or flights of stairs traversed by a user, the monitoring device comprising (i) a housing having a physical size and shape that is adapted to couple to the body of the user, (ii) an altitude sensor, disposed in the housing, to detect a change in altitude of the user and, in response thereto, to generate data which is representative of the change in altitude of the user, and (iii) processing circuitry, disposed in the housing and coupled to the motion sensor and the altitude sensor, to calculate a number of stairs or flights of stairs traversed by the user using the data which is representative of a change in altitude of the user.

DETECTION OF OVARIAN CANCER

Among other things, the present disclosure provides a method including the steps of: obtaining a uterine sample; and detecting and/or characterizing in the uterine sample an ovarian cancer biomarker (e.g., CA125). 1. A method comprising steps of:obtaining a uterine sample; andmeasuring in the uterine sample an ovarian cancer biomarker level.2. The method of claim 1 , wherein the ovarian cancer biomarker is CA-125.3. The method of claim 1 , wherein the ovarian cancer biomarker is selected from the group consisting of HE4 claim 1 , mesothelin claim 1 , and YKL-40.4. The method of claim 1 , wherein the step of obtaining comprises obtaining a uterine wash sample.5. The method of claim 1 , wherein the step of obtaining comprises obtaining a sample in vivo.6. The method of claim 5 , wherein the step of measuring occurs in vivo.7. The method of claim 6 , wherein the step of obtaining and the step of measuring are performed via a bio-sensing device implanted in vivo.8. The method of claim 7 , further comprising transmitting a signal from the bio-sensing device to a remote sensor claim 7 , the signal corresponding to data obtained during the step of measuring.9. The method of claim 1 , further comprising adjusting a therapy based on data obtained during the step of measuring.10. The method of claim 1 , further comprising repeatedly performing the step of measuring.11. The method of claim 10 , further comprising adjusting a therapy based on data obtained during the step of repeatedly performing the step of measuring.12. The method of claim 1 , wherein the step of measuring comprises determining that the biomarker is present at a level higher than a reference level.13. The method of claim 12 , wherein the reference level is correlated with presence or absence of cancer.14. The method of claim 12 , wherein the reference level is correlated with absence or presence of cancer at a particular stage.15. The method of claim 1 , wherein the step of measuring comprises determining ...

APPARATUS AND METHOD FOR MEASURING A TISSUE ANALYTE SUCH AS BILIRUBIN USING THE BREWSTER'S ANGLE

A tissue analyte measuring device () includes a light source () structured to emit unpolarized light toward the skin surface of a subject, and a detector assembly () configured to receive light reflected the skin surface of the subject and the transcutaneous tissues of the subject, the detector assembly including a polarizing filter () and a number of light detector subassemblies (). The polarizing filter is structured to filter out s-polarized light and pass only p-polarized light to light detector subassemblies. The light source is structured and positioned to emit the unpolarized light in a manner wherein the unpolarized light will exit the measuring device at a predetermined angle with respect to a normal to a light emitting plane of the measuring device, wherein the predetermined angle is an angle (the Brewster's angle) at which only s-polarized light will be reflected by the skin surface when the unpolarized light is incident thereon. 12. A tissue analyte measuring device () , comprising:{'b': 4', '6, 'a light source () structured and positioned to emit unpolarized light toward a skin surface () of a subject when the measuring device is positioned adjacent to the skin surface; and'}{'b': 8', '12', '14, 'a detector assembly () configured to receive light reflected from the subject including light reflected by the skin surface of the subject and by transcutaneous tissues of the subject, the detector assembly including a polarizing filter () and a number of light detector subassemblies (), the polarizing filter being structured to filter out s-polarized light and pass only p-polarized light to the number of light detector subassemblies.'}27. The measuring device according to claim 1 , wherein the light source is structured and positioned to emit the unpolarized light in a manner wherein the unpolarized light will exit the measuring device at a predetermined angle with respect to a normal to a light emitting plane () of the measuring device claim 1 , the light ...

Methods for Analyte Monitoring Management and Analyte Measurement Data Management, and Articles of Manufacture Related Thereto

Generally, methods of analyte monitoring management, and articles of manufacturing related thereto, are provided. The methods include receiving analyte measurement data and analyzing the analyte measurement data for health related parameters. Recommendations are determined for creating or modifying a treatment program based on the analysis, and provided within a user-interface that enables a user to create or modify the treatment program. Further, generally, methods of for managing analyte measurement data, and articles of manufacturing related thereto, are provided. The methods include receiving analyte measurement data that represent data collected over a time period, and analyzing the analyte measurement data for analyte episodes within that time period. Threshold based episodes and/or rate-of-change based episodes may be determined.

SYSTEMS, DEVICES, AND METHODS INCLUDING PARAMAGNETIC OSCILLATION, ROTATION, AND TRANSLATION OF HEMOZOIN ASYMMETRIC NANOPARTICLES IN RESPONSE TO DARK-FIELD OR RHEINBERG DETECTION OF THE PRESENCE OF HEMOZOIN

Systems, devices, and methods are described for providing a monitor/treatment device configured to, for example, detect hemozoin, as well as to monitor or treat a malarial infection. 111.-. (canceled)12. A method , comprising:generating a comparison between (a) a detected scattering profile information associated with a plurality of target regions within a biological tissue interrogated by a dark-field interrogation stimulus in the presence of a magnetic field stimulus and (b) reference hemozoin dark field scattering information; andmagnetically perturbing hemozoin nanoparticles in the biological tissue based in part on the comparison.13. The method of claim 12 , wherein generating the comparison includes comparing claim 12 , using circuitry claim 12 , a detected scattering profile associated with a plurality of target regions within a biological subject interrogated by a multiplexed dark-field interrogation stimulus in the presence of a magnetic field stimulus and reference hemozoin dark field scattering information.14. The method of claim 12 , further comprising:generating a comparison, using circuitry, between a detected scattering profile obtained using a Rheinberg illumination configuration in the presence of a magnetic field stimulus and reference hemozoin Rheinberg illumination spectral information.15. The method of claim 12 , wherein magnetically perturbing the hemozoin nanoparticles in a biological tissue includes applying a magnetic field stimulus of a character and for a duration sufficient to cause the hemozoin nanoparticles in a biological tissue to affect the integrity of a digestive food vacuole of a malaria parasite.16. The method of claim 12 , wherein magnetically perturbing the hemozoin nanoparticles in a biological tissue includes applying an alternating magnetic field stimulus of a character and for a duration sufficient to cause the hemozoin nanoparticles in a biological tissue to rupture a membrane of a digestive food vacuole of a malaria ...

DEVICE FOR CLAMPING A HOSE LINE FOR DETERMINING THE CONCENTRATION OF A BLOOD CONSTITUENT

A device for clamping a hose line for determining the concentration of a constituent of blood in a hose line, in particular in the hose line of an extracorporeal blood circuit of an extracorporeal blood treatment apparatus, includes a clamping unit with two receiving elements and an electric motor-driven actuation mechanism. Actuation mechanism is constituted such that, when a clamping force is applied, the first and second receiving element can be moved from a position releasing the hose line into a position clamping the hose line. Moreover, the device comprises an unlocking mechanism which is constituted such that, by actuating an unlocking element, the actuation mechanism in the position clamping the hose line can be decoupled from electromotive drive. Unlocking mechanism makes it possible for the receiving elements to be transferred easily and rapidly by hand from the position clamping the hose line into the position releasing the hose line. 1. A device for clamping a hose line for determining a concentration of a constituent of blood in a hose line of an extracorporeal blood circuit of an extracorporeal blood treatment apparatus , comprising:a clamping unit which comprises first and second receiving elements for clamping the hose line;a measurement unit for coupling electromagnetic radiation through the hose line into the blood and measuring the electromagnetic radiation emerging through the hose line from the blood,wherein the clamping unit comprises an actuation mechanism and an electromotive drive for the actuation mechanism, wherein the actuation mechanism is constituted such that, when a clamping force is applied, the first and second receiving elements move from a position releasing the hose line into a position clamping the hose line, andwherein the clamping unit comprises an unlocking mechanism, which is constituted such that, by actuating an unlocking element, the actuation mechanism in the position clamping the hose line is decoupled from the ...

OPTICAL SENSOR DEVICE AND IMAGE PROCESSING UNIT FOR MEASURING CHEMICAL CONCENTRATIONS, CHEMICAL SATURATIONS AND BIOPHYSICAL PARAMETERS

Optical sensor devices, image processing devices, methods and computer readable code computer-readable storage media for detecting biophysical parameters, chemical concentrations, chemical saturations and blood count. In some embodiments, the image processing device receives a live still or video electronic image. Exemplary physiological parameters include but are not limited to a pulse rate, blood pressure, glucose, stroke volume of internal or external tissue (e.g. skin). A biophysical or physiological property is not limited to a cardiovascular or liver or the kidneys or to a cardiovascular disorder or to a pulmonary disorder. Exemplary chemical concentrations or saturation includes but not limited to a pH level, a glucose level, a urea nitrogen level, a CO2 concentration or saturation, or a oxygen concentration or saturation. In some embodiments the parameters are detected from a food or a beverage such as an alcohol, a dairy product, wine, a baked good, a fruit or a vegetable. 1. An image processing device for obtaining biophysical information about a mammalian subject , said image processing device comprising:an image receiving unit for receiving a video electronic color image of a first tissue of the mammalian subject, the electronic color image comprising spatial temporal per pixel information for a color space of a first visible color, spatial temporal per pixel information for a color space of a second visible color and spatial temporal per pixel information for a color space of a third visible color, the electronic color image derived from light reflected from and/or traversing the first tissue, the light incident from a continuous or discontinuous, filtered or unfiltered, natural or artificial, light source and having a wavelength between near UV and near IR; andan image processing unit for electronically processing said image by transforming per pixel information for the first, second and third visible colors to transformed per pixel information for the ...

SYSTEM, METHOD AND ARTICLE FOR NORMALIZATION AND ENHANCEMENT OF TISSUE IMAGES

In medical imaging, a fiducial marker facilitates tissue image correlation that allows for image analysis, normalization and correction of the optical exposure and spectral and spatial distribution in order to compensate for the surface reflections, sub surface tissue interactions and spatial orientation of the excitation and imaging axes to the subject tissue. Using a cross comparison, clinicians can model tissue image data in different forms in order to reference and compare data from various spectral components and or from different images. This may enhance human interpretation between images including the variations between images even when the spectral, spatial and optical conditions or the image resolution or sensitivity are compromised. Such may be used to assess cosmetic, moisturizing, therapeutic materials and treatments. 129.-. (canceled)30. A system for use in tissue analysis , the system comprising:at least one processor; andat least one nontransitory storage medium that stores processor executable instructions which when executed cause the at least one processor to:compare an appearance of at least one shape of at least a first fiducial marker in a first digital image of a portion of a tissue to at least one defined actual shape of the fiducial marker;compare an appearance of each of a plurality of sections of the fiducial marker in the first digital image to respective ones of defined sections of the fiducial marker including a number of tissue phantoms each having a respective spectral characteristic that matches a respective spectral characteristic of tissue of a type represented in the first digital image; andat least one of correlate, normalize, or correct at least the first digital image, based at least in part on the comparisons.31. The system of wherein the fiducial marker includes a scatter layer that overlies at least some of the tissue phantoms and which simulates an optical character of the type of tissue represented in the first digital ...

DEVICE FOR MONITORING AND/OR IMPROVING THE EFFICIENCY OF PHYSICAL TRAINING

A device for monitoring the efficiency of physical training in a human or animal includes a millimeter wave generator that generates millimeter wave radiation and a millimeter wave antenna that emits millimeter waves generated by the millimeter wave generator in a predetermined direction. The device includes a coupling element that couples the millimeter wave antenna to the millimeter wave generator and that transmits the millimeter wave radiation to the millimeter wave antenna. The device also includes a reference element that intermittently receives millimeter wave radiation from the millimeter wave antenna and a detector that detects millimeter wave radiation and produces a first data stream. The device further includes a processing unit that receives the first data stream and generates a signal indicating development of a body lactate level over time and an output device indicating the development of the body lactate level over time, to a user. 1. A device for monitoring and/or improving the efficiency of physical training in a human or animal , comprising:at least one millimeter wave generator that generates millimeter wave radiation,at least one millimeter wave antenna that emits millimeter waves generated by said millimeter wave generator in a predetermined direction,at least one coupling element that couples said millimeter wave antenna to said millimeter wave generator and that transmits said millimeter wave radiation generated by said millimeter wave generator to said millimeter wave antenna,at least one reference element, whereby said at least one reference element at least intermittently receives millimeter wave radiation from said millimeter wave antenna,at least one detector that detects millimeter wave radiation and produces a first data stream,a processing unit that receives said first data stream from said at least one detector and generates a signal indicating a development of a body lactate level over time, andan output device indicating said ...

MONITORING SYSTEM FOR CARDIAC SURGICAL OPERATIONS WITH CARDIOPULMONARY BYPASS

A monitoring system for cardiac operations with cardiopulmonary bypass comprising: a processor operatively connected to a heart-lung machine; a pump flow detecting device connected to a pump of the heart-lung machine to continuously measure the pump flow value and send it to the processor; a hematocrit reading device inserted inside the arterial or venous line of the heart-lung machine to continuously measure the blood hematocrit value and to send it to the processor; a data input device to allow the operator to manually input data regarding the arterial oxygen saturation and the arterial oxygen tension; computing means integrated in the processor to compute the oxygen delivery value on the basis of the measured pump flow, the measured hematocrit value, the preset value of arterial oxygen saturation, and the preset value of arterial oxygen tension; and a display connected to the processor to display in real-time the computed oxygen delivery value. 1. A method of monitoring a patient's parameters during a cardiac operation with cardiopulmonary bypass and a heart-lung machine , the method comprising:detecting a pump flow (Qp) value from a pump of the heart-lung machine;detecting a hematocrit (HCT) value from the arterial or venous line of the heart-lung machine;obtaining an arterial oxygen saturation (Sat(a)) value derived from an arterial blood of the patient;obtaining an arterial oxygen tension (PaO2) value derived from the arterial blood of the patient;calculating an oxygen delivery (DO2) value;calculating a carbon dioxide production (VCO2) value; anddisplaying a comparison of the DO2 value and the VCO2 value.2. The method of claim 1 , further comprising calculating a hemoglobin (Hb) value from the HCT value.3. The method of claim 2 , further comprising calculating an arterial oxygen content (CaO2) value from the Hb value claim 2 , the Sat(a) value and the PaO2 value.4. The method of claim 2 , further comprising calculating the DO2 value from the pump flow rate Qp ...

System for In Vivo Biosensing Based on the Optical Response of Electronic Polymers

A system for continuous in vivo biosensing of specific analyte molecule concentrations based on the dynamic optical properties of electronic polymers is disclosed. The biosensor system includes at least one implant member subcutaneously exposed to the interstitial fluid of the subject, and a reader member at least temporarily positioned over the implant member to probe it with light of specific wavelengths through the skin. The system has many potential applications, including the real-time monitoring of blood glucose levels in diabetics as a method to supplement or replace conventional capillary blood testing.

METHOD TO DETERMINE SODIUM VALUES DESCRIBING THE CONTENT OF 23NA+, AND LOCAL COIL FOR USE IN SUCH A METHOD

In a method to determine at least one sodium value describing the 23Na+ content in at least one region of interest in a target region in the body of a patient, at least one sodium image data set of the target region is acquired with a magnetic resonance imaging device using sodium-23 imaging, the sodium image data set including image data dependent on the occurrence of sodium. The at least one region of interest is defined for which the sodium value is to be determined in the sodium image data set. The sodium value is determined by comparison of the image data in the region of interest with reference image data of at least one subject with a defined 23Na+ content, the reference image data having been acquired with the same sequence. A local coil can be used to implement the method that has a phantom integrated therein that allows the sodium image data set and the reference image data to be acquired together. 1. A method to determine at least one sodium value describing 23N+ content in at least one region of interest in a target region in the body of a patient , comprising:operating a magnetic resonance data acquisition unit with a sequence configured for sodium-23 imaging sequence to acquire at least one sodium image data set of a target region of the body of a patient in the magnetic resonance data acquisition unit, said at least one sodium image data set comprising image data dependent on a presence of sodium in said target region;in a computerized processor, defining at least one region of interest for which a sodium value is to be determined in said sodium image data set; andproviding said processor with reference image data also acquired using said sequence configured for sodium-23 imaging sequence and, in said processor, determining said sodium value by comparing image data in said at least one sodium image data set, that represent a region of interest within said target region, with said reference image data.2. A method as claimed in comprising generating ...

Systems and Methods for Visualizing Ablated Tissue

Systems and methods for visualizing ablated tissue are disclosed. In some embodiments, a system for imaging tissue includes a catheter having an expandable balloon at a distal end, an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native nicotinamide adenine dinucleotide hydrogen (NADH) in the tissue, and an imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera. 1. A system for imaging tissue comprising:a catheter having an expandable balloon at a distal end;an illumination device positioned within the balloon for propagating light from an external light source for illuminating a tissue being treated to excite native reduced nicotinamide adenine dinucleotide (NADH) in the tissue; andan imaging device positioned within the balloon for detecting fluorescence from the illuminated tissue, the imaging device being configured to communicate detected NADH fluorescence to an external fluorescence camera.2. The system of further comprising an ablation device for ablating the tissue.3. The system of claim 1 , wherein the tissue being treated is heart tissue.4. The system of further comprising a display system connected to the camera for generating an image of the illuminated tissue based on the detected NADH fluorescence.5. The system of claim 4 , wherein in the image tissue that was effected by a treatment is illustrated as having less fluorescence than tissue not affected by the treatment6. The system of further comprising a dichroic mirror and a plurality of filters for conditioning light from the light source and light reflected by the tissue.7. A system for imaging tissue comprising:a catheter system configured to position an illumination device and an imaging device in proximity to a tissue;an ablation device ...

Simultaneous acquisition of biometric data and nucleic acid

Disclosed are devices and methods for collection and analyzing biological samples containing nucleic acid in conjunction with collecting at least one ridge and valley signature of a test subject, while keeping the sample and signature associated with each other. Such devices and methods are used in forensic, human identification, screening, and access control technologies to rapidly process an individual's identity or determine the identity of an individual.

MEDICAL SENSOR AND TECHNIQUE FOR USING THE SAME

In an embodiment, a sensor may be adapted to provide information related to its position on a patient's tissue. The sensor may include tissue contact sensors which may relay a signal related to the proper placement of the sensor relative to the tissue of a patient. Such a sensor may be useful for providing information to a clinician regarding the location of the sensor in relation to the skin of a patient in order to provide improved measurements. 1. A system comprising:a sensor body;an emitter and a detector disposed adjacent the sensor body; anda tissue contact sensor disposed adjacent the sensor body, wherein the tissue contact sensor comprises a temperature sensor configured to measure a temperature; anda processor coupled to the tissue contact sensor configured to determine whether the sensor is on a tissue of a patient based, at least in part, on the measured temperature.2. The system of claim 1 , wherein the temperature sensor comprises a thermistor.3. The system of claim 1 , wherein the processor is configured to compare the measured temperature to a threshold value to determine whether the sensor is on the tissue of the patient.4. The system of claim 3 , wherein the threshold value comprises a clinically determined average skin surface temperature.5. The system of claim 1 , wherein the tissue contact sensor comprises a second temperature sensor configured to measure an ambient temperature.6. The system of claim 5 , wherein the processor is configured to determine whether the sensor is on the tissue of the patient based claim 5 , at least in part claim 5 , on a difference between the measured temperature and the measured ambient temperature.7. A pulse oximetry system comprising:a pulse oximetry monitor comprising a processor; and a sensor body;', 'an emitter and a detector disposed adjacent the sensor body; and', 'a tissue contact sensor disposed adjacent the sensor body, wherein the tissue contact sensor comprises a temperature sensor configured to provide ...

Biological information processing method and device, recording medium and program

Provided is a biological information processing method and a device, a recording medium and a program that are able to predict and control changes in the state of an organism. The expression level of molecules in an organism is measured over a specific time interval; the measured time-series data is divided into a periodic component, an environmental stimulus response component and a baseline component; constant regions of the time-series data are identified from variations in the baseline component or from the amplitude or periodic variations of the periodic component; and causal relation between the identified constant regions is identified. The relation between the external environment and variations in the internal environment is identified and from the identified causal relation between the constant regions, changes in the state of the organism are inferred.

Sample cell for fluid analysis system

Systems and method are disclosed for determining a concentration of an analyte (e.g., glucose) in a fluid (e.g., blood). The system can draw blood from a patient and deliver the blood to a sample cell. A centrifuge motor can spin the sample cell to separate the fluid into a plurality of components (plasma, red blood cells, etc.). A particular component of the fluid (e.g., plasma) may be positioned at a sample portion of the sample cell after centrifuging such that the concentration of the analyte is measured in the particular component of the fluid (e.g., plasma). The sample cell can include a cuvette that has two window pieces sandwiched between two clamshell pieces, and where the sample portion of the sample cell is defined by a gap between the window pieces.

Holder and light measurement device employing same

Provided is a holder which comprises at least two probe mount portions into which a light-transmitting probe for emitting light from the tip thereof or a light-receiving probe for receiving light through the tip thereof is inserted from above and is to be put on the head of a subject, the holder being characterized by further comprising: a linear backbone portion that extends in a first direction that is perpendicular to the above-described direction from above; and at least two linear branch portions that extend in a second direction that is perpendicular to the above-described direction from above and is different from the first direction, wherein the lower end portions of the probe mount portions protrude from the lower surface of the backbone portion or a branch portion and are tapered.

Systems and methods for determining physiological parameters using measured analyte values

Systems and methods for determining a physiological parameter in a patient are provided. In certain embodiments, a system can include an analyte detection system configured to measure first analyte data in a fluid sample received from a patient, a medical sensor configured to measure second analyte data in the patient, and a processor configured to receive the first analyte data and the second analyte data and to determine a physiological parameter based at least in part on the first analyte data and the second analyte data. In certain such embodiments, the medical sensor may be a pulse oximeter, and the physiological parameter may include a cardiovascular parameter including, for example, cardiac output.

Methods and systems for in vivo clinical data measurement of analytes

The present invention provides apparatuses, systems, and methods for real-time measuring of analytes in a biological fluid sample of a subject. In particular, the present invention provides a combination of micro-dialysis catheter, a micro-volume pump, and a spectrometer device that are operatively connected to one another to provide real-time measurement of analytes in a biological fluid sample of a subject.

Non-invasive ocular monitoring

A device for measuring an analyte concentration level in a subject. The device includes: a light source configured for illuminating at least a portion of an anterior region of an eye of the subject with incident light having a substantially broad illumination spectrum at an angle substantially tangential to the surface of the eye; an optical collector configured for detecting reflected light from the at least a portion of the anterior region of the eye; an analyzer configured for analyzing the detected reflected light; and a processor configured to determine the analyte concentration level in the subject based on the analyzed reflected light.

PHOTOPLETHYSMOGRAPHY DEVICE AND METHOD

A system and method for measuring one or more light-absorption related blood analyte concentration parameters of a mammalian subject, is disclosed. In some embodiments, the system comprises: a) a photoplethysmography (PPG) device configured to effect a PPG measurement by illuminating skin of the subject with at least two distinct wavelengths of light and determining relative absorbance at each of the wavelengths; b) a dynamic light scattering measurement (DLS) device configured to effect a DLS measurement of the subject to rheologically measure a pulse parameter of the subject; and c) electronic circuitry configured to: i) temporally correlating the results of the PPG and DLS measurements; and ii) accordance with the temporal correlation between the PPG and DLS measurements, assessing value(s) of the one or more light-absorption related blood analyte concentration parameter(s). 1. A method of measuring one or more light-absorption related blood analyte concentration parameters of a mammalian subject , the method comprising:a) effecting a photoplethysmography (PPG) measurement of the subject by illuminating skin of the subject with at least two distinct wavelengths of light and determining relative absorbance at each of the wavelengths;b) effecting a dynamic light scattering measurement (DLS) of the subject to rheologically measure a pulse parameter of the subject;c) temporally correlating the results of the PPG and DLS measurements; andd) in accordance with the temporal correlation between the PPG and DLS measurements, assessing value(s) of the one or more light-absorption related blood analyte concentration parameter(s).2. The method of wherein the blood analyte concentration parameter is selected from the group consisting of a blood oxihemoglobin concentration parameter claim 1 , a blood carboxyhemoglobin concentration parameter and an arteriovenous oxygen difference (AV difference) parameter.3. The method of wherein temporal correlating and/or value assessing ...

PULSE OXIMETRY SYSTEM

Systems and methods for estimating a saturation level of oxygen in hemoglobin (SpO2) are provided. In some aspects, a system includes a detector module configured to receive an oximeter output signal indicative of light absorption in a patient. The oximeter output signal alternates between infrared light components and red light components, and includes a first portion obtained at least partly during switching from at least one of the infrared components to at least one of the red components. The oximeter output signal also includes a second portion obtained at least partly during switching from at least one of the red components to at least one of the infrared components. The system also includes a processing module configured to estimate an SpO2 of the patient as a ratio between (i) a time derivative of the first portion and (ii) a time derivative of the second portion. 1. A system , for estimating a saturation level of oxygen in hemoglobin (SpO) , comprising: a first portion obtained at least partly during switching from at least one of the infrared components to at least one of the red components; and', 'a second portion obtained at least partly during switching from at least one of the red components to at least one of the infrared components; and, 'a detector module configured to receive an oximeter output signal indicative of light absorption in a patient, the oximeter output signal alternating between infrared light components and red light components and comprising{'sub': '2', 'a processing module configured to estimate an SpOof the patient as a ratio between (i) a time derivative of the first portion and (ii) a time derivative of the second portion.'}2. The system of claim 1 , wherein the oximeter output signal alternates between the infrared light components and the red light components according to a predetermined frequency.3. The system of claim 2 , wherein the time derivative of the first portion is with respect to a switching time duration claim 2 , ...

Signal Processing Method, Signal Processing Apparatus, and Pulse Photometer Using the Same

A method of processing first and second signals obtained by measuring a medium, to obtain a pulse wave signal and an artifact signal which are separated, includes: separating vectors of the first and second signals by using a separation matrix into a vector of the pulse wave signal and a vector of the artifact signal, the separation matrix including a norm ratio of a stable zone of the pulse wave signal and a compensated norm ratio of an artifact zone. 1. A method of processing first and second signals obtained by measuring a medium , to obtain a pulse wave signal and an artifact signal which are separated , the method comprising:separating vectors of the first and second signals by using a separation matrix into a vector of the pulse wave signal and a vector of the artifact signal, the separation matrix including a norm ratio of a stable zone of the pulse wave signal and a compensated norm ratio of an artifact zone.3. The method according to claim 1 , wherein a moving average process with a predetermined number of points is performed on the pulse wave signal.4. A biological signal processing apparatus comprising:a measuring unit measuring the first and second signals; and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a processing unit processing the first and second signals by using the method according to .'}5. A pulse photometer including the biological signal processing apparatus according to claim 4 , and calculating at least one of an oxygen saturation of arterial blood claim 4 , a dyshemoglobin concentration claim 4 , and dye concentration injected in the blood claim 4 ,wherein the first and second signals are electric signals into which lights obtained by causing two kinds of light beams, which are emitted from a light emitter and which have different wavelengths, to be transmitted through or reflected from living tissue corresponding to the medium are converted, andwherein a component of the artifact signal is removed by using the compensated norm ratio ...

Delivering and/or receiving fluids

The present invention generally relates to receiving bodily fluid through a device opening. In one aspect, the device includes a flow activator arranged to cause fluid to be released from a subject. A deployment actuator may actuate the flow activator in a deployment direction, which may in turn cause fluid release from a subject. The flow activator may also be moved in a retraction direction by a retraction actuator. In one aspect, the device may include a vacuum source that may help facilitate fluid flow into the opening of the device and/or may help facilitate fluid flow from the opening to a storage chamber. In one aspect, a device actuator may enable fluid communication between the opening and the vacuum source and the flow activator may be actuated after the enablement of fluid communication.

NMR SYSTEMS FOR IN VIVO DETECTION OF ANALYTES

This invention relates generally to NMR systems for in vivo detection of analytes. More particularly, in certain embodiments, the invention relates to systems in which superparamagnetic nanoparticles are exposed to a magnetic field and radio frequency (RF) excitation at or near the Larmor frequency, such that the aggregation and/or disaggregation of the nanoparticles caused by the presence and/or concentration of a given analyte in a biological fluid is detected in vivo from a monitored RF echo response. 1. A nuclear magnetic resonance system for assessing the presence or concentration of an analyte contained in a body fluid of a mammal in-vivo , the system comprising:(a) a sensor suitable for partial or complete implantation within the mammal's body, the sensor comprising structure defining a sample volume and a port, the sample volume containing magnetic particles, and the port allowing the analyte to enter the sample volume and preventing, partly or completely, the magnetic particles from leaving the sample volume, the extent of aggregation of the magnetic particles being indicative of the presence or concentration of the analyte in the sample volume;(b) a reader for disposition outside the mammal's body, the reader providing results based on sensor indication of presence or concentration of the analyte in the sample volume;(c) a magnet or magnetic field generator;(d) a radiofrequency coil for applying a radiofrequency pulse sequence to the sample volume in the presence of a magnetic field provided by the magnet or magnetic field generator; and(e) means for determining the position of the sensor within the mammal's body.2. The system of claim 1 , wherein the radiofrequency coil acts as a sensing radiofrequency coil and an excitation radiofrequency coil.3. The system of claim 1 , wherein the sensor comprises the radiofrequency coil of (d) or a further radiofrequency coil.4. The system of claim 1 , wherein the reader comprises the radiofrequency coil of (d) or a ...

METHOD AND SYSTEM FOR NON-INVASIVELY MONITORING BIOLOGICAL OR BIOCHEMICAL PARAMETERS OF INDIVIDUAL

A system and method are presented for use in monitoring one or more conditions of a subject's body. The system includes a control unit which includes an input port for receiving image data, a memory utility, and a processor utility. The image data is indicative of data measured by a pixel detector array and is in the form of a sequence of speckle patterns generated by a portion of the subject's body in response to illumination thereof by coherent light according to a certain sampling time pattern. The memory utility stores one or more predetermined models, the model comprising data indicative of a relation between one or more measurable parameters and one or more conditions of the subject's body. The processor utility is configured and operable for processing the image data to determine one or more corresponding body conditions; and generating output data indicative of the corresponding body conditions. 1. A system for use in monitoring one or more conditions of a subject's body , the system comprising a control unit comprising:an input port for receiving image data measured by a pixel detector array and being in the form of a sequence of speckle patterns generated by a portion of the subject's body in response to illumination thereof by coherent light according to a certain sampling time pattern;a memory utility for storing one or more predetermined models, the model comprising data indicative of a relation between one or more measurable parameters and one or more conditions of the subject's body; and processing the image data and determining a spatial correlation function between successive speckle patterns in the sequence, and determining a time varying spatial correlation function in the form of a time-varying function of at least one feature of the correlation function, the time-varying spatial correlation function being indicative of a change of the speckle pattern over time;', 'selecting at least one parameter of the time-varying spatial correlation function, ...

Apparatus and program for evaluating biological function

An apparatus and a program are provided which are capable of simultaneously measuring, evaluating, imaging and displaying the biological function of sites with different biological functions, such as the brain and the muscle, different parts of the brain or different muscle locations, using near-infrared spectroscopy. In an apparatus for evaluating biological function K, physiological indices, including parameters derived from changes in deoxyhemoglobin concentration and changes in oxyhemoglobin concentration, are calculated by a calculating part of a controller. To measure simultaneously, evaluate, image and display the biological functions of sites with different biological function, such as the brain and the muscle, different parts of the brain or different muscle locations, these physiological indices from different sites of the living body are adjusted in such a way that they can be compared with each other by the calculating part and displayed by a display part. 1. An apparatus for evaluating biological function that is an apparatus for evaluating biological function having a plurality of living body probes for irradiating light to and receiving emitted light from a plurality of sites with different biological functions of a living body , and an apparatus body for entering light information detected by means of said plurality of living body probes and performing calculation , control and memory operations , and utilizing the near-infrared spectroscopy method , wherein said plurality of sites of said living body with different biological functions include at least a brain site and a muscle site , wherein said apparatus body comprising:a calculating part for calculating amounts of change in oxyhemoglobin concentration and amounts of change in deoxyhemoglobin concentration and/or physiological indices including a variety of parameters derived from the relationships between them, based on light information from said plurality of living body probes;an adjusting ...

Activity Monitoring Systems and Methods of Operating Same

The present inventions, in one aspect, is an activity monitoring system comprising a fixture having size/shape adapted to couple to a location on the user's body and a particular signature; and a portable monitoring device adapted to detect the fixture's particular signature. The monitoring device includes a housing that is adapted to engage the fixture; an activity sensor, disposed in the housing, to detect activity of the user and to generate data which is representative of the activity of the user; and processing circuitry, disposed in the housing, to calculate an activity-related quantity of the user, wherein the processing circuitry determines the monitoring device is engaging the fixture by detecting the fixture's particular signature and calculates the activity-related quantity. 1. An activity monitoring system comprising:a plurality of fixtures, wherein each fixture includes a physical size and shape that is adapted to couple to an associated location on the body of the user; a housing to separately and physically engage each fixture;', 'an activity sensor, disposed in the housing, to detect activity of the user and, in response thereto, to generate data which is representative of the activity of the user; and', automatically determines a particular fixture of the plurality of fixtures is physically engaging the portable monitoring device, and', 'calculates at least one activity-related quantity of the user which is associated with the particular fixture., 'processing circuitry, disposed in the housing and coupled to the activity sensor, to calculate one or more activity-related quantities of the user using the data which is representative of the activity of the user, wherein the processing circuitry], 'a portable monitoring device adapted to separately and physically engage each fixture of the plurality of fixtures, the portable monitoring device including2. The activity monitoring system of wherein:at least one fixture of the plurality of fixtures includes ...

IONIC BARRIER FOR FLOATING GATE IN VIVO BIOSENSORS

An ion-sensitive sensor includes a dielectric layer comprising AlOhaving a functionalized surface configured to bond with an analyte. The ion-sensitive sensor is immersed in an electrolytic solution containing a concentration of alkali ions. An electrode is arranged to apply an electric potential to the functionalized surface of the ion-sensitive sensor. In some embodiments the ion-sensitive sensor is an ion-sensitive silicon FET. In some embodiments the ion-sensitive sensor is an ion-sensitive polymer FET. In some embodiments, the electrode comprises a perforated gate metal layer disposed on the gate dielectric layer of an ion-sensitive FET, and the functionalized surface is disposed in openings of the perforated gate metal layer. In some embodiments the dielectric layer comprises a multi-layer dielectric stack including at least one AlOlayer. In some embodiments the dielectric layer is deposited by atomic layer deposition (ALD). 1. A system comprising:{'sub': 2', '3, 'an ion-sensitive sensor that includes a dielectric layer including AlO;'}an electrolytic solution in which the ion-sensitive sensor is immersed, the electrolytic solution containing a concentration of alkali ions, a surface of the dielectric layer of the ion-sensitive sensor being in contact with the electrolytic solution; andan electrode arranged to apply an electric potential to the surface of the dielectric layer in contact with the electrolytic solution.2. The system of claim 1 , wherein the surface of the dielectric layer in contact with the electrolytic solution is a functionalized surface configured to bond with an analyte.3. The system of claim 2 , wherein the ion-sensitive sensor is an ion-sensitive silicon field effect transistor (FET) and the dielectric layer in contact with the electrolytic solution is the gate dielectric layer of the ion-sensitive silicon FET.4. The system of claim 3 , wherein the electrode comprises a perforated gate metal layer disposed on the gate dielectric layer of ...

Fluid injection and safety system

Various medical systems and methods are described, including a medical monitoring system. The medical monitoring system can have a fluid system configured to receive bodily fluid and optically analyze said fluid to determine analyte concentration. The fluid system can have a removable portion. The removable portion can have an opening with a port. The system can also have a container configured to contain anticoagulant. The container can have a portion configured to mate with the port of the removable portion. The container can be further configured to not fit into a conventional luer fitting. An anti-coagulant insertion apparatus is also described. The apparatus can have a syringe, a dock with a port, and an adapter configured to connect the syringe to the port. The dock can also have a tab configured to move with the port.

Analyte Sensor

Systems and methods of use for continuous analyte measurement of a host's vascular system are provided. In some embodiments, a continuous glucose measurement system includes a vascular access device, a sensor and sensor electronics, the system being configured for insertion into communication with a host's circulatory system. 1. A method for measuring an analyte in a host , comprising:exposing a continuous analyte detection system to a sample, wherein the continuous analyte detection system comprises a continuous analyte sensor configured for contact with a sample from a circulatory system of a host in vivo and configured to generate a first signal associated with a test analyte and a second signal associated with a reference analyte, and a reference sensor configured to generate a reference signal associated with the reference analyte;receiving the first signal, the second signal, and the reference signal;calculating a calibration factor associated with a sensitivity of the continuous analyte sensor; andcalibrating the first signal, wherein calibrating comprises using the calibration factor.2. The method of claim 1 , wherein the exposing step further comprises simultaneously exposing the continuous analyte sensor and the reference sensor to the sample.3. The method of claim 1 , wherein the receiving step further comprises receiving the first signal from a first working electrode disposed under an enzymatic portion of a membrane system.4. The method of claim 3 , wherein the receiving step further comprises receiving the second signal from the first working electrode.5. The method of claim 3 , wherein the receiving step further comprises receiving the second signal from a second working electrode disposed under the membrane system.7. The method of claim 5 , wherein the receiving step further comprises receiving a non-analyte-related signal from a third working electrode disposed under a non-enzymatic portion of the membrane system.8. The method of claim 1 , wherein ...

Noninvasive detection of meconium in amniotic fluid

Meconium stained amniotic fluid can indicate intrauterine fetal distress. The invention provides a system and method for detecting meconium in released amniotic fluid in pregnant women, including a collection body such as a hygienic pad, having a meconium detector. This invention is designed to be employed mainly by a lay person at home; it also may provide possible etiologies for fetal distress.

Emergency Medical Diagnosis and Communications Device

A portable emergency medical device capable of communicating with a remote location preferably as a cellular telephone that can measure one or more human vital parameters such as pulse rate, body temperature, skin moisture, blood pressure, ECG or blood chemistry and can receive symptoms from a user either by voice recognition or by keypad and can provide an expert medical diagnosis. The device can store a complete medical history for one or more users and can use an expert system to make the diagnosis. The device can make an emergency medical call either on command or automatically requesting help and optionally supplying medical information and/or GPS location information. 1. A personal medical diagnosis apparatus comprising:a cellular telephone module including a processor and memory;a medical expert system disposed in said memory and executable on said processor;a medical probe that measures at least one human medical parameter, said probe being in data communication with said medical expert system; andan input device, including a keyboard and circuitry through which the medical expert system receives symptom data;the expert system receiving imputed symptom data and at least one medical parameter and making a medical diagnosis.2. The personal medical diagnosis apparatus of further comprising a GPS receiver in communication with said processor claim 1 , wherein said processor is adopted to report a geographic location of said medical diagnosis apparatus to a remote station.3. The personal medical diagnosis apparatus of further comprising a housing wherein said medical probe is at least one of:a blood pressure sensor in or deployable from said housing;a pulse rate sensor in or deployable from said housing;a body temperature sensor in or deployable from said housing, or;an ECG interface in or deployable from said housing.4. The personal medical diagnosis apparatus of further comprising a housing wherein said medical probe is at least one of:a blood pressure sensor ...

SWALLOWABLE CAPSULE FOR MONITORING A CONDITION

A swallowable capsule () is provided with a drug reservoir () and at least one sensor (). The drug reservoir () is arranged to hold a pharmaceutical composite. A wall () of the drug reservoir () comprises at least one opening for allowing fluid from the surroundings of the capsule () to enter the drug reservoir () and for allowing dissolved drug or liberated particles of the pharmaceutical composite to enter the surroundings of the capsule (). The at least one sensor () is provided for monitoring a condition of the surroundings of the capsule (). 110. A swallowable capsule () , comprising:{'b': 18', '12', '10', '18', '10, 'a drug reservoir () for holding a pharmaceutical composite, with a wall () comprising at least one opening for allowing fluid from the surroundings of the capsule () to enter the drug reservoir () and for allowing dissolved drug or liberated particles of the pharmaceutical composite to enter the surroundings of the capsule (), and'}{'b': 13', '10, 'at least one sensor () for monitoring a condition of the surroundings of the capsule ().'}210181018. A swallowable capsule () as claimed in claim 1 , wherein the drug reservoir () can be opened or detached from the capsule () in order to allow placement of the pharmaceutical composite in the reservoir ().310181212. A swallowable capsule () as claimed in claim 1 , wherein the drug reservoir () comprises a meshed wall () claim 1 , the meshed wall () comprising the at least one opening.41012. A swallowable capsule () as claimed in claim 3 , wherein the meshed wall () is injection molded.51012. A swallowable capsule () as claimed in claim 3 , wherein the meshed wall () comprises meshed metal wires.61013. As swallowable capsule () as claimed in claim 1 , wherein the sensor () is capable of providing time-stamped data.7101513. A swallowable capsule () as claimed in claim 1 , further comprising a transmitter () coupled to the sensor () for transmitting sensor information regarding the monitored condition to an ...

DEVICES AND METHODS FOR BODY FLUID SAMPLING AND ANALYSIS

Described here are meters and methods for sampling, transporting, and/or analyzing a fluid sample. The meters may include a meter housing and a cartridge. In some instances, the meter may include a tower which may engage one or more portions of a cartridge. The meter housing may include an imaging system, which may or may not be included in the tower. The cartridge may include one or more sampling arrangements, which may be configured to collect a fluid sample from a sampling site. A sampling arrangement may include a skin-penetration member, a hub, and a quantification member. 1. An integrated body fluid sampling meter comprising:a meter housing comprising a light source and a first detector; anda disposable cartridge insertable into the meter housing and comprising a plurality of cells, wherein each cell has a first wall comprising a viewing window and a second wall comprising a light-blocking covering,wherein one of the plurality of cells is positionable between the light source and the first detector.2. The meter of wherein the disposable cartridge is rotatable within the meter housing.3. The meter of wherein the meter is configured to initiate an indexing protocol upon insertion of the disposable cartridge into the meter housing claim 2 , wherein the integrity of each cell is checked.4. The meter of further comprising a processor claim 3 , and wherein the processor is configured to index each cell as either available or used during the indexing protocol.5. The meter of wherein the meter housing comprises a contact pad and wherein the disposable cartridge is movable between a testing position claim 4 , where an available cell is aligned with the contact pad claim 4 , and a standby position claim 4 , where each of the plurality of cells is out of alignment with the contact pad.6. The meter of wherein the light-blocking covering is a foil seal.7. The meter of wherein the meter housing comprises a punch for puncturing the foil seal.8. The meter of wherein the ...

Multiple wavelength sensor emitters

A physiological sensor has light emitting sources, each activated by addressing at least one row and at least one column of an electrical grid. The light emitting sources are capable of transmitting light of multiple wavelengths and a detector is responsive to the transmitted light after attenuation by body tissue.

Systems And Methods For Using Photoplethysmography In The Administration Of Narcotic Reversal Agents

Provided according to embodiments of the present invention are methods of monitoring and treating respiratory depression that include securing a photoplethysmography (PPG) sensor to a central source site of an individual; administering a central nervous system (CNS) depressant to the individual; processing PPG signals front the PPG sensor with a computer in communication with the PPG sensor; and administering a narcotic reversal agent to the individual if the PPG signals or a physiological parameter derived therefrom are outside a preset value range. Related systems are also described. 1. A method of monitoring and treating respiratory depression comprising:securing a photoplethysmography (PPG) sensor to a central source site of an individual;administering a central nervous system (CNS) depressant to the individual;processing PPG signals from the PPG sensor with a controller in communication with the PPG sensor; andadministering a narcotic reversal agent to the individual if the PPG signals or a physiological parameter derived therefrom are outside a preset value range.2. The method of claim 1 , wherein the narcotic reversal agent is administered to the individual if a respiration rate of the individual is outside the preset value range.3. The method of claim 1 , wherein the narcotic reversal agent is administered to the individual if a respiratory effort of the individual is outside the preset value range.4. The method of claim 1 , wherein the narcotic reversal agent is naloxone.5. The method of claim 1 , further comprising securing to the individual an additional sensor configured to determine at least one parameter selected from respiration rate claim 1 , end-tidal carbon dioxide content claim 1 , blood pressure claim 1 , heart rate and heart rate variability.6. The method of claim 5 , wherein the narcotic reversal agent is administered if (a) the PPG signals or a physiological parameter derived therefrom are outside a first preset value range; and (b) a ...

Sensor Arrangement for Detecting Muscle Activity for the Control of Technical Equipment

A sensor arrangement for detecting muscle activity for the control of technical equipment. When in use the arrangement covers a region of the skin surface of a user, to provide a signal indicative of muscle activity in a limited region for subsequent processing. The arrangement has at least one double-differential myoelectric sensor, together with at least one near-infrared sensor. These are for simultaneous or time-delayed derivation of (a) myoelectric activity and (b) the value of a parameter of the blood (for example the blood oxygen content or the relative quantity of haemoglobin) respectively, in the muscle, the muscles or the tissue under the arrangement.

Method and System for Providing an Integrated Analyte Sensor Insertion Device and Data Processing Unit

Method and apparatus for providing an integrated analyte sensor and data processing unit assembly is provided. 1. An apparatus , comprising: a housing;', 'a data processing unit disposed in the housing;', 'an introducer disposed within the housing and including a first portion having a sharp distal end configured for piercing through a skin layer, wherein the first portion of the introducer is retained within the housing after piercing through the skin layer; and', wherein the first portion of the analyte sensor is configured for transcutaneous placement so as to be in fluid contact with an interstitial fluid;', 'wherein the second portion of the analyte sensor is in electrical contact with the data processing unit prior to transcutaneous placement of the first portion of the analyte sensor; and', 'wherein the housing, the data processing unit and the introducer are assembled to form the disposable assembly, and the data processing unit includes an aperture through which the introducer is removable., 'an analyte sensor including a first portion and a second portion, the first portion of the analyte sensor coupled to the first portion of the introducer, and the second portion of the analyte sensor coupled to the data processing unit;'}], 'a disposable assembly including2. The apparatus of further including an adhesive layer provided on a lower surface of the data processing unit claim 1 , wherein the adhesive layer is configured to removably attach the housing to the skin surface.3. The apparatus of claim 2 , wherein the adhesive layer includes a removable protective layer.4. The apparatus of wherein the first portion of the introducer includes a sharp tip for piercing through the skin layer claim 1 , wherein when the sharp tip is pierced through the skin layer claim 1 , the first portion of the analyte sensor is transcutaneously placed under the skin layer and in fluid contact with the interstitial fluid.5. The apparatus of wherein the introducer is configured to ...

Scanning Optoacoustic Imaging System with High Resolution and Improved Signal Collection Efficiency

Provided herein are scanning, high-resolution optoacoustic imaging systems or microscopes. Generally, the system/microscope comprises subsystems for scanning a tissue or object therein with a wavelength of electromagnetic energy, such as optical energy, collecting and detecting ultrasonic waves produced when the tissue or object absorbs the incident wavelength and converting the same to an electrical signal, and for processing, analyzing and displaying the electrical signal as a digital image. Specifically, the system/microscope utilizes an off-axis parabolic reflector with a high numerical aperture value for deep tissue visualization. Also, provided is a method for collecting volumetric image data voxel-by-voxel within a subject utilizing the imaging system or microscope. A series of voxels within the scanned tissue produces detectable ultrasonic waves that are collected by the off-axis parabolic reflector and processed as described as a high-resolution image of the tissue or object therein. 1. A scanning three dimensional optoacoustic imaging system , comprising:a) an electromagnetic energy delivery subsystem having a source of electronmagnetic energy deliverable to an object of interest in a subject;b) an ultrasound collection subsystem comprising an off-axis parabolic reflector disposed in a focusable relationship with a voxel of the object of interest that received the electromagnetic energy, said voxel generating detectable ultrasonic waves;c) an ultrasound detection subsystem comprising at least one ultrawide-band ultrasonic transducer configured to convert the detectable ultrasonic waves to an electrical signal;d) a scanning subsystem disposed in movable relationship to the ultrasound collection subsystem and ultrasound detection subsystem;e) an electronic subsystem comprising analog amplification, analog-to-digital conversion and digital signal processing components configured for acquisition and digital conversion of the electrical signals; andf) a ...

SYSTEMS AND METHODS USING BIOMARKER PANEL DATA

Embodiments of the disclosure are related to systems and methods for utilizing biomarker panel data and related medical devices and methods, amongst other things. An embodiment can include a method of screening patients. The method can include quantifying levels of one or more of a panel of biomarkers in a biological sample of a patient. The method can further include analyzing the quantified levels. In some embodiments, the panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4. In an embodiment, the disclosure can include a method of diagnosing a patient. The method can include quantifying levels of one or more of a panel of biomarkers in a biological sample of a patient. The method can further include diagnosing the patient based at least in part on the quantified levels. In some embodiments, the panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4. Other embodiments are also included herein. 1. A method of screening patients:quantifying levels of one or more of a panel of biomarkers in a biological sample of a patient; andanalyzing the quantified levels;wherein the panel of biomarkers includes at least two selected from the group consisting of CRP, SGP-130, sIL-2R, sTNFR-II, IFNg, BNP, sST2, MMP-2, MMP-9, TIMP-1, TIMP-2, TIMP-4.2. The method of claim 1 , wherein analyzing the quantified levels includes determining whether the patient is at risk for experiencing heart failure decompensation.3. The method of claim 1 , wherein analyzing the quantified levels includes determining whether the patient is at risk for rapid decline in clinical symptoms of heart failure.4. The method of claim 1 , wherein analyzing the quantified levels includes determining whether the patient is at risk for adverse ventricular remodeling.5. The method of claim 1 , ...

Flexible Electrode for Detecting Changes in Temperature, Humidity, and Sodium Ion Concentration in Sweat

The present invention includes a flexible sensor suitable for contact with skin comprising: a nanocomposite; and a top layer; where the sensor provides in-situ detection in sweat or other aqueous body fluids at the skin surface of at least one physiological parameter selected from the group consisting of a physiological salt component, temperature, moisture, humidity, or combinations thereof. The present invention further includes a method of fabricating a flexible sensor suitable for contact with skin comprising: electrospinning at least one polyamide-producing monomer to form a non-conductive polyamide substrate; attaching at least one plurality of conductive nanoscale attachments, wherein the nanoscale attachments are selected from nanotubes, nanoparticles, or combinations thereof, to form an intermediate layer; and functionalizing the intermediate layer to form a top layer. 2. The flexible sensor of where the nanocomposite further comprises a substrate and an intermediate layer.3. The flexible sensor of claim 2 , where the substrate is non-conductive.4. The flexible sensor of claim 2 , where the substrate is a polyamide.5. The flexible sensor of claim 4 , where the polyamide is nylon-6.6. The flexible sensor of claim 2 , where the substrate is a fabric claim 2 , scrim claim 2 , sock claim 2 , mat claim 2 , scaffold claim 2 , or textile.7. The flexible sensor of claim 2 , where the substrate is formed by electrospinning.8. The flexible sensor of claim 2 , where the intermediate layer is conductive.9. The flexible sensor of claim 2 , where the intermediate layer is ceramic.10. The flexible sensor of claim 2 , where the intermediate layer is carbon.11. The flexible sensor of claim 2 , where the intermediate layer is graphene.12. The flexible sensor of claim 2 , where the intermediate layer comprises nanoparticles claim 2 , nanofibers claim 2 , nanotubes claim 2 , or combinations thereof.13. The flexible sensor of claim 11 , where the nanotubes are multi-walled ...

Compositions And Methods For Measurement of Analytes

Disclosed herein are compositions comprising an oblong optode sensing agent. The oblong optode sensing agent comprises a core and a semipermeable membrane, wherein the core comprises one or more sensors configured to bind to an analyte. In addition, methods of making and detecting the oblong optode sensing agents are disclosed. 1. An oblong optode sensing agent , the oblong optode sensing agent comprising a core and a semipermeable membrane , wherein the core comprises one or more sensors configured to bind to an analyte.2. The optode sensing agent of claim 1 , wherein the one or more sensors covalently bind to the analyte.3. The optode sensing agent of claim 1 , wherein the one or more sensors are fluorescent sensors.4. The optode sensing agent of claim 2 , wherein the analyte is selected from the group consisting of electrolytes claim 2 , salts claim 2 , hormones claim 2 , steroids claim 2 , small molecules claim 2 , drugs claim 2 , and saccharides.5. The optode sensing agent of claim 1 , wherein the core further comprises a polymer.6. The optode sensing agent of claim 1 , wherein the semipermeable membrane comprises a hydrogel.7. The optode sensing agent of claim 5 , wherein the semipermeable membrane comprises a biocompatible hydrogel.8. The optode sensing agent of claim 1 , wherein the semipermeable membrane is permeable to analyte and impermeable to the one or more sensors.9. The optode sensing agent of claim 5 , wherein the core comprises one or more polymers selected from the group consisting of polyvinyl chloride claim 5 , polylactic co-glycolic acid claim 5 , methacrylate claim 5 , and polycaprolactone10. The optode sensing agent of claim 1 , wherein the optode sensing agent has a circular cross-section.11. The optode sensing agent of claim 1 , wherein the optode sensing agent has a rectangular shape.12. The optode sensing agent of claim 10 , wherein the optode sensing agent has a length of about 40 μm to about 60 μm.13. The optode sensing agent of claim ...

BIODETECTOR

The invention concerns a Biodetector with a functionalised surface for isolating molecules or cells from the human body. In order to improve a Biodetector of the type mentioned above such that the functionalised surface of the Biodetector or there upon enriched molecules or cells are exposed to a lower abrasion, and the biocompatibility of the Biodetector is improved, the Biodetector is designed to remove a fluid from the human body and absorb it into an inner space of the Biodetector, wherein the functionalised surface is oriented to the inner space of the Biodetector. 1. Biodetector with comprising:a functionalised surface for isolation of molecules or cells from a human body, wherein the Biodetector is configured to remove a fluid from the human body, and to absorb it into an inner space of the Biodetector, wherein the functionalised surface is oriented to the inner space of the Biodetector.2. Biodetector according to claim 1 , wherein the functionalised surface is at least partially occupied with detection molecules.3. Biodetector according to claim 2 , wherein the detection molecule includes antibodies claim 2 , selected from a group consisting of monoclonal antibodies claim 2 , chimeric antibodies claim 2 , humanized antibodies claim 2 , antibody fragments or amino acid structures and amino acid sequences claim 2 , nucleic acid structures and nucleic acid sequences claim 2 , carbohydrate structures claim 2 , and synthetic structures.4. Biodetector according to claim 2 , wherein the detection molecules are of non-human origin.5. Biodetector according to claim 1 , wherein the detection molecules are connected and oriented to the functionalised surface.6. Biodetector according to claim 1 , wherein the detection molecules are covalently attached to the functionalised surface.7. Biodetector according to claim 1 , wherein the Biodetector has a fluid removable section claim 1 , which satisfies at least one of the following requirements:a. The fluid removal section ...

Heart Age Assessment

An automated method of determining a measure of a subject's heart age comprising the steps of: prompting a user for a plurality of inputs, each relating to an attribute of the subject, each attribute defining one or more of a demographic status of the subject, a lifestyle status of the subject, a physical condition of the subject and a medical history of the subject; receiving, from the user, a plurality of said inputs; determining from said received inputs, a set of parameters for which input data has been received as input from the user; selecting a heart age calculation algorithm from a predetermined set of heart age calculation algorithms according to said set of parameters; and calculating a heart age for the subject according to the selected algorithm; and providing as output said calculated heart age. 122-. (canceled)23. An automated method of estimating blood lipid levels of a subject , said method carried out on a computer system and comprising the automated steps of:a) receiving a plurality of data values, each relating to an attribute of the subject, each attribute defining one or more of a demographic status of the subject, a lifestyle status of the subject, a physical condition of the subject and a medical history of the subject, the data values not including any quantitative measure of a cholesterol level of the subject, said data values either provided by the user through a user input device of the computer system or transferred electronically from another device;b) calculating a CVD risk for the subject based on said data values using a first algorithm stored in a database on the computer system;c) determining one or a range of possible total cholesterol levels and HDL cholesterol levels for the subject consistent with the calculated first CVD risk by comparison of the first CVD risk with statistical average CVD risk as a function of measured total and HDL cholesterol levels in a population;d) determining a statistical average total cholesterol level ...

SENSORS FOR DETECTING SUBSTANCES IN BODILY FLUIDS

A system is disclosed that extracts bodily fluid to a reaction chamber for monitoring a substance or property of the patient fluid. In one embodiment, a pump is used to advance the sample of bodily fluid through a filter to produce a filtrate. Another pump advances filtrate into the reaction chamber, while another pump advances reactant into the reaction chamber. A sensor in communication with the reaction chamber determines a concentration of nitric oxide or one of its metabolic products. Methods are also disclosed. 1. An apparatus for measuring nitrite in blood of a human or animal subject , the apparatus comprising:a housing, at least a portion of which is configured for placement in a blood vessel of the subject;a size-exclusion filter within the housing, configured to allow nitrite ions to pass through the filter and impede passage of particles having a molecular weight greater than about 60 kD through the filter;a nitrite reduction agent within the housing, configured to reduce nitrite ions to nitric oxide; anda nitric oxide electrode within the housing for measuring nitric oxide.2. The apparatus of claim 1 , wherein the housing comprises a needle configured for advancement into a blood vessel of the subject.3. The apparatus of claim 1 , wherein the filter is configured to allow nitrite molecules to pass through the filter.4. The apparatus of claim 1 , wherein the filter is configured to exclude hemoglobin and erythrocytes.5. The apparatus of claim 1 , further comprising a vacuum source coupled with the housing claim 1 , configured to improve flux through the filter.6. The apparatus of claim 1 , wherein the filter comprises a membrane comprising a material selected from the group consisting of polycarbonate claim 1 , polysulfone claim 1 , polyethersulfone claim 1 , polyarylethersulfone claim 1 , polyurethane claim 1 , polyacrylonitrile claim 1 , regenerated cellulose claim 1 , mixed cellulose ester claim 1 , polyester claim 1 , Nylon claim 1 , poly(vinylidene ...

PATIENT SUPPORTING DEVICE, TREATMENT APPARATUS WITH A PATIENT SUPPORTING DEVICE AND CORRESPONDING METHOD FOR CONTROLLING AND/OR REGULATING A MEDICAL TREATMENT DEVICE

The subject matter is a patient supporting device for supporting a patient during a medical treatment, in particular a dialysis treatment, and a treatment apparatus with such a patient supporting device, and a corresponding method for controlling and/or regulating a medical treatment device, in particular a dialysis device, using such a patient supporting device. 1. Patient supporting device for supporting a patient [ ["a device for coupling a measurement signal into the patient's body and", "a device for coupling an electrical measurement value thereby generated in the patient's body out of the patient's body,"], 'wherein this apparatus comprises'}, 'wherein via this interface the data correlated with the electrical measurement value can be transmitted to the medical treatment device, by means of which the medical treatment device can be controlled and/or regulated.', 'and an interface for connecting to a medical treatment device,'}], "with an apparatus for carrying out a bioimpedance measurement on a patient's body,"}2. Patient supporting device according to claim 1 , characterized in thatthe medical treatment device is a dialysis device.3. Patient supporting device according to claim 1 , characterized in thatthe apparatus for carrying out a bioimpedance measurement comprises a device for determining the patient's weight.4. Patient supporting device according to claim 1 , characterized in that the apparatus for carrying out a bioimpedance measurement comprises at least two electrodes for contacting the patient's body for coupling the measurement signal into the patient's body (=coupling-in electrodes) claim 1 , preferably by impressing a measurement current into the patient's body claim 1 , andat least two electrodes for contacting the patient's body for coupling the electrical measurement value generated by the measurement signal in the patient's body out of the patient's body (=coupling-out electrodes), preferably by capturing a change in potential generated by ...

WIRELESS ELECTRODE ARRANGEMENT AND METHOD FOR PATIENT MONITORING VIA ELECTROCARDIOGRAPHY

A system including a plurality of wireless sensors for monitoring one or more parameters of a subject is provided. The wireless sensors can be attachable to or implantable in the subject and form a network. The sensors can include a sensing component configured to detect a signal corresponding to at least one condition of the subject. The sensors further can include a communication component configured to wirelessly transmit the detected signal to at least another of the plurality of wireless sensors, and wirelessly receive a signal transmitted from at least one of the remaining sensors in the network. 1. A system for monitoring one or more hemodynamic parameters of a subject , comprising: a sensing component configured to detect a signal corresponding to at least one hemodynamic condition of the subject;', wirelessly transmit the detected signal to at least one of the plurality of wireless sensors, and', 'wirelessly receive a signal transmitted from at least one of the remaining sensors in the network., 'a communication component configured to], 'a plurality of wireless sensors attachable to or implantable in the subject and forming a network, each sensor comprising2. The system of claim 1 , wherein the network is a mesh network.3. The system of claim 1 , wherein the hemodynamic parameters include one or more of pulse oximetry claim 1 , oxygen saturation claim 1 , oxyhemoglobin saturation claim 1 , blood glucose level claim 1 , blood pressure claim 1 , blood velocity claim 1 , blood flow rate claim 1 , respiratory rate claim 1 , pulse rate claim 1 , COlevel claim 1 , drug concentration claim 1 , blood protein concentration claim 1 , heart rate claim 1 , heart rhythm claim 1 , heart rate variability claim 1 , organic or inorganic substance concentration claim 1 , cardiac activity claim 1 , cardiac output claim 1 , pH levels claim 1 , pathogens and galvanic skin response.4. The system of claim 1 , wherein each of the plurality of wireless sensors further comprises:a ...

CONFIGURABLE PATIENT MONITORING SYSTEM

A patient monitoring system can display one or more configurable health monitors on a configurable user interface. The health indicators are configured to display a physiological signal from a patient. The patient monitoring system can calculate ranges of values for the health indicator that correspond to a status of the patient. The health indicators can display different outputs based on the value of the physiological signal. 1. A patient monitoring system , comprising:at least one physiological sensor including a first and second light emitter and a detector, wherein the physiological sensor is configured to measure at least one physiological signal from a patient;at least one health indicator, wherein the health indicator is configured to display a signal value based upon the at least one physiological signal; receive patient information;', 'calculate a first range of values for the at least one health indicator based at least in part on the patient information, wherein the first range of values corresponds to a first range of physiological signals from the patient, wherein the first range of values corresponds to a first patient condition;', 'calculate a second range of values for the at least one health indicator based at least in part on the patient information, wherein the second range of values corresponds to a second range of physiological signals from the patient, wherein the second range of values corresponds to an second patient condition; and, 'a processorwherein the at least one health indicator is configured to display a first output when the signal value is within the first range of values; andwherein the at least one health indicator is configured to display a second output when the signal value is within the second range of values.2. The patient monitoring system of claim 1 , wherein the first patient condition is a healthy condition.3. The patient monitoring system of claim 1 , wherein the first patient condition is an unhealthy condition.4. The ...

ENDOSCOPE SYSTEM, PROCESSOR DEVICE THEREOF, AND IMAGE PRODUCING METHOD

First and second white light is generated by excitations of phosphors with first and second laser beams having center wavelengths of 473 nm and 445 nm, respectively. The first and second white light is applied, in respective frames, sequentially to a region of interest in a subject. A color image sensor images the region of interest in the each frame. Based on a shift amount, calculated from green signals of first and second frames, between images, an image of a blue signal of the first frame is moved to be aligned with an image of a green signal and an image of a red signal of the second frame. After the alignment, an oxygen saturation image representing an oxygen saturation level of hemoglobin in blood is produced from the blue signal of the first frame and green and red signals of the second frame, and displayed on a display. 1. An endoscope system comprising:a lighting section for applying at least first illumination light and second illumination, light, in respective frames, to a region of interest, a wavelength range of the first illumination light being different from a wavelength range of the second illumination light, the region of interest including a blood vessel;an image signal acquisition section having a color image sensor with an array of pixels of at least three primary colors, the image signal acquisition section imaging the region of interest in the each frame, the image signal acquisition section imaging the region of interest illuminated with the first illumination light to acquire three color signals of a first frame, the image signal acquisition section imaging the region of interest illuminated with the second illumination light to acquire three color signals of a second frame;a shift amount calculator for calculating a shift amount between an image of the first frame and an image of the second frame based on the color signals of same color;a registration section for aligning images of predetermined color signals, used for calculating an ...

Method and System for Differential Diagnosis of Chronic Schizophrenia and Chronic Alcoholism

Biomarker diagnosis of chronic schizophrenia in the presence of cognitive impairment is confirmed when Phosphocreatine (PCr) levels are increased, compared to normal levels, in both the left and right prefrontal cortices of the brain, with increased PCr specifically also in the left basal ganglia and also reduced NA/Crin the left superior temporal region of the brain. Biomarker differential diagnosis is also taught for chronic alcoholism (with or without cognitive impairment) and for chronic schizophrenia even when cognitive impairment is absent. 1. A method for the differential diagnosis of chronic schizophrenia or chronic alcoholism , comprising imaging the brain of a subject in need of diagnosis for the markers PCr , NA/Cr , and sPDE and determining any increase or decrease in the presence of said markers compared to normal levels in specified anatomic areas of the brain , and outputting the results of the imaging as one or more files or images to be viewed by a user.2. The method according to claim 1 , wherein after quantifying PCr claim 1 , NA/Crand sPDE claim 1 , a determination that (1) PCr levels are increased claim 1 , compared to normal levels claim 1 , in both the left and right prefrontal cortices of the brain claim 1 , together with increased (2) PCr specifically also in the left basal ganglia and also (3) reduced NA/Crin the left superior temporal region of the brain claim 1 , together confirm a differential diagnosis of chronic schizophrenia when cognitive impairment is present.3. The method according to claim 1 , wherein after quantifying PCr claim 1 , NA/Crand sPDE claim 1 , a determination that (1) phosphocreatine (PCr) levels are increased in the right basal ganglia claim 1 , with (2) reduced NA/Crin all three of: (a) the left basal ganglia; (b) the right occipital cortex; and (c) the left centrum semiovale claim 1 , together with (3) reduced sPDE in the right inferior parietal and the right centrum semiovale claim 1 , together confirm a ...

REFLECTION-DETECTOR SENSOR POSITION INDICATOR

A reflection-detector sensor position indicator comprises emitters that transmit light having a plurality of wavelengths. A detector outputs a sensor signal. At least one reflection detector outputs at least one sensor position signal. An attachment assembly attaches the emitters, the detector and the reflection detector onto a tissue site. A sensor-on condition indicates that the attachment assembly has positioned the emitters generally centered over a fingernail, the detector on a fingertip opposite the fingernail and the reflection detector over the fingernail. The sensor signal, in the sensor-on condition, is at least substantially responsive to the emitter transmitted light after attenuation by pulsatile blood flow perfused within a fingernail bed underneath the fingernail. The sensor position signal, in the sensor-on condition, is at least substantially responsive to the emitter transmitted light after reflection off of the fingernail. 1. An optical sensor configured to provide an indication of a physiological parameter comprising:a plurality of emitters that transmit light having a plurality of wavelengths;a detector that outputs a sensor signal, the sensor signal is at least substantially responsive to the emitter transmitted light after attenuation by pulsatile blood flow perfused within a fingernail bed underneath the fingernail; andat least one reflection detector that outputs at least one sensor position signal, the sensor position signal including a sensor-on condition indicating that the attachment assembly has positioned the emitters generally centered over a fingernail, the detector on a fingertip opposite the fingernail and the at least one reflection detector over the fingernail, the at least one sensor position signal, in the sensor-on condition, is at least substantially responsive to the emitter transmitted light after reflection off of the fingernail.an attachment assembly that attaches the emitters, the detector and the at least one reflection ...

ANXIETY MONITORING

A patient monitoring system comprises a probe module () to acquire data of a patient to be monitored. An evaluation module () to determines a patient's state of anxiety on the basis of the acquired data. An indicator module () to feedback the determined state of anxiety to attending staff. Thus, the staff is enabled on the basis of the feedback from the patient monitoring system to re-assure patients where that is needed and beneficiary. 1. A patient monitoring system comprisinga probe module to acquire data of a patient to be monitored, wherein the probe module includes a salivary cortisol assay to measure a salivary cortisol level or blood cortisol level,an evaluation module to determine a patient's state of anxiety on the basis of the acquired data, the evaluation module configured to determine the patient's state on the basis of the salivary cortisol level or blood cortisol level, andan indicator module to feedback the determined state of anxiety to attending staff.2. The patient monitoring system as claimed in claim 1 , whereinthe probe module is configured to acquire primary data and optionally to acquire additional data of the patient ["to make a primary assessment of the patient's state of anxiety from the primary data and optionally make a refined assessment of the patient's state of anxiety on the basis of the additional data and", 'to control the probe module on the basis of the primary assessment to acquire the additional data and to engage in the refined assessment., 'the evaluation module is configured'}3. The patient monitoring system as claimed in claim 1 , wherein the evaluation module includes a self-learning function.4. The patient monitoring system as claimed in claim 1 , wherein the evaluation module is configured to access patient reference data and to evaluate the patient's state taking the patient reference data into account.5. The patient monitoring system as claimed in claim 1 , wherein the probe module includes a camera to monitor the ...

SYSTEM AND METHOD TO EVALUATE CARDIOVASCULAR HEALTH

Systems and methods are described herein to evaluate a candidate medication as it relates to a subject's cardiovascular health. A processing component is employed to measure a first value of one or more cardiovascular markers, via a computer, which are associated with a circulatory system of each subject that is to receive the candidate medication. The candidate medication is administered to each subject and a second value of one or more cardiovascular markers are measured subsequent to the administration as of the candidate medication. Continued testing of the candidate medication can be continued dependent upon the change in the one or more cardiovascular markers. 1. A method , comprising:a processing component employed to calculate a first stroke volume of a subject;administering a medication to the subject;calculating a second stroke volume of the subject; andevaluating the disparity between the first stroke volume and the second stroke volume to determine whether to continue administration of the medication,wherein if the second stroke volume is less than or equal to the first stroke volume, administration of the medication is continued and if the second stroke volume is greater than the first stroke volume, administration of the medication is discontinued.2. The method according to claim 1 , wherein the medication is related to modification of the cardiovascular system of the subject.3. The method according to claim 2 , wherein the cardiovascular medication is related to hypertension.4. The method according to claim 1 , wherein the first and second stroke volumes are calculated based upon the same cardiovascular markers.5. The method according to claim 1 , wherein the first and second stroke volumes are calculated based upon a cardiac output and a heart rate of the subject claim 1 , wherein the first and second stroke volumes are each equal to the cardiac output divided by the heart rate.6. The method according to claim 1 , wherein the first and second stroke ...

GUIDE FOR PLACEMENT OF CATHETER INTO BRAIN AND A METHOD OF UTILIZING THE SAME

The subject matter discloses an apparatus for detecting an environment within a body comprising: an apparatus comprising a stylet and a catheter capable of being inserted into the body; a bio-sensing module for detecting a predefined material within the body, upon insertion of the stylet and catheter with close proximity to the predefined material 1. An apparatus for detecting an environment within a body comprising:an apparatus comprising a stylet and a catheter capable of being inserted into the body;a bio-sensing module for detecting a predefined material within the body, upon insertion of the stylet and catheter with close proximity to the predefined material.2. The apparatus of wherein the bio-sensing module further indicates the presence of the predefined material.3. The apparatus of wherein the indication is provided using electrical connecting element.4. The apparatus of wherein the predefined material is beta-transferrin.5. The apparatus of wherein at least a portion of the bio-sensing module is located within the stylet.6. The apparatus of wherein the bio-sensing module comprises a biosensor claim 1 , transmitter and an indication unit.7. The apparatus of wherein the bio-sensing module is located in a cavity within the stylet.8. The apparatus of claim 7 , wherein the stylet further comprises one or more apertures for allowing fluid containing the predefined material to enter the stylet cavity.9. The apparatus of wherein the predefined material contacts and activates the bio-sensing module.10. The apparatus of wherein at least a portion of the biosensor is located outside surface of the stylet.11. A method of inserting a catheter or trocar into a body comprising:a. inserting an apparatus comprising a stylet and catheter into the body;b. detecting a predefined material by a biosensor connected to the apparatus upon close proximity of the apparatus to the predefined material.12. The method according to claims 11 , further comprises a step of transmitting data ...

Sensing Patch Applications

Various methods, devices and systems for patch based physical, physiological, chemical, and biochemical sensors that diagnose and monitor disease states are described. The patch based sensors provide a panel of specific analyte parameters that determine one or more physiological conditions and/or the level of healing progression of a wound. The use of such analyte panels in local or remote monitoring of parameters related to various disease states is also described. 1. A wound healing indicator device comprising:a functional layer, wherein the functional layer determines the level of at least one specific parameter from wound exudates and provides an indication as to the status of a wound healing process.2. The wound healing indicator device of claim 1 , further comprising a carrier layer.3. The wound healing indicator device of claim 1 , further comprising a sampling layer.4. The wound healing indicator device of claim 3 , wherein the sampling layer operates through at least one of an electrophoretic mechanism claim 3 , an electrokinetic mechanism claim 3 , a capillary effect claim 3 , a pressure driven mechanism claim 3 , and combinations thereof.5. The wound healing indicator device of claim 1 , wherein the at least one specific parameter includes concentration of chemical or biochemical agents associated with at least one of bacteria claim 1 , inflammation cytokines claim 1 , proteases claim 1 , growth factors claim 1 , ECM receptors claim 1 , pH claim 1 , iconicity claim 1 , NO/O claim 1 , temperature claim 1 , integrins claim 1 , and combinations thereof.6. The wound healing indicator device of claim 1 , wherein the status of the wound healing process is indicated through at least one of a color change claim 1 , a digital display claim 1 , and combinations thereof.7. The wound healing indicator device of claim 6 , wherein the color change is provided by use of at least one of a coulometric assay claim 6 , a luminescence assay claim 6 , an electrochemical assay ...

Analyte Monitoring System and Methods

Methods and systems for providing data communication in medical systems are disclosed. 1. An analyte monitoring system , comprising:a data processing unit; anda control unit in wireless communication with the data processing unit, the control unit configured to transmit one or more predefined close proximity commands to the data processing unit;wherein the data processing unit is configured to perform one or more predefined functions in response to the received one or more predefined close proximity commands.2. The system of wherein the data processing unit includes a close proximity receiver coupled to an antenna for receiving the one or more predefined close proximity commands from the control unit.3. The system of wherein the data processing unit is configured to transmit one or more signals related to a monitored analyte level in response to the received one or more predefined close proximity commands.4. The system of wherein the communication of the one or more predefined close proximity commands is performed when the data processing unit and the control unit are within a predetermined distance from each other.5. The system of wherein the predetermined distance includes a distance of less than one foot.6. The system of including a memory unit.7. The system of wherein the memory unit includes an EEPROM.8. The system of wherein the control unit includes an application specific integrated circuit (ASIC) configuration.9. The system of including an analyte sensor coupled to the data processing unit claim 1 , wherein the data processing unit receives one or more signals from the analyte sensor.10. The system of wherein the control unit and the data processing unit are in wireless communication using RF communication protocol.11. A method claim 9 , comprising:positioning a controller unit within a transmission range for close proximity communication;transmitting one or more predefined close proximity commands; andreceiving a response packet in response to the ...

Urine Shield

A urine shield comprises an elongate base and side walls connected to the base. At least one of the sides and base is absorbent. The shield further comprises at least one attachment tab for releasably attaching the shield to a user's skin The shield has an hourglass shaped cross-section. A method and device for the collection of a urine sample from an individual is also provided. 1. A urine shield comprising an elongate base and side walls connected to the base , at least one of said side walls and base being absorbent or supporting an absorbent element , the shield further comprising at least one attachment tab for releasably attaching the shield to a user's skin , wherein the shield has an hourglass shaped cross-section.2. A urine shield according to claim 1 , wherein the hourglass shaped cross-section is either symmetrical or asymmetrical about the waist.3. A urine shield according to claim 1 , wherein both the side walls and the base are absorbent.4. A urine shield according to claim 1 , wherein the at least one attachment tab is provided with an adhesive.5. A urine shield according to with a detachable portion forming the base.6. A urine shield according to claim 1 , wherein the shield is stackable with respect to another shield.7. A urine shield according to claim 1 , wherein the at least one attachment tab is attached to the side walls.8. A urine shield according to claim 1 , wherein at least one of the base and sides is provided with a urine indicator that changes colour when exposed to urine.9. A urine shield according to claim 1 , wherein each of the base and side walls further comprise an outer layer claim 1 , the outer layer being substantially water resistant.10. A urine shield according to claim 1 , further comprising a sterile absorbent pad.11. A urine shield according to claim 1 , wherein the sterile absorbent pad is removable.12. A urine shield according to claim 1 , further comprising an assay strip.13. A urine shield according to claim 12 , ...

Physiological Parameter Measuring Platform Device Supporting Multiple Workflows

A device obtains a series of measurements of a physiological parameter of one or more patients. The device displays a monitoring workflow home screen when the device is operating within a monitoring workflow. The device displays a non-monitoring workflow home screen when the device is operating within a non-monitoring workflow. The device displays a continuous workflow home screen when the device is operating within a continuous workflow. The monitoring workflow home screen, the non-monitoring workflow home screen, and the continuous workflow home screen are each different.

TRANSCUTANEOUS ANALYTE SENSOR

The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host. 1. A system for measuring an analyte in a host , comprising: an electronics unit;', 'a mounting unit releasably matable to the electronics unit; and', ["an in vivo portion adapted for insertion through an exit port of the mounting unit and through an exit site of the host's skin; and", "an ex vivo portion adapted to remain above the host's skin after insertion of the in vivo portion and to operably connect to the electronics unit,"], 'a sensor comprising], 'an on-skin assembly comprising{'sup': 3', '3, 'wherein the electronics unit, when releasably mated to the mounting unit, together comprise a subassembly that has a volume of less about 8 cmand a thickness of less than about 10 mm, whereby motion artifacts cased by motion of the subassembly translating to the sensor in vivo is reduced as compared to a subassembly that has a volume of greater than about 8 cmand a thickness of greater than about 10 mm.'}2. The system of claim 1 , wherein the electronics unit claim 1 , when releasably mated to the mounting unit claim 1 , together comprise a subassembly that has a volume of less about 6 cmand a thickness of less than about 9 mm claim 1 , whereby motion artifacts caused by motion of the subassembly translating to the sensor in vivo is reduced as compared to a subassembly that has a volume of greater than about 6 cmand a thickness of greater than about 9 mm.3. The system of claim 1 , wherein the electronics unit and housing each comprise a mutually engaging electrical contact.4. The system of claim 1 , wherein the mounting unit comprises an elastomeric sealing member for sealing the operable connection of the sensor with the electronics unit.5. The system of claim 1 , wherein the sensor exits the mounting unit at an edge or near an edge of the device ...

CARDIAC CATHETER EMPLOYING CONFORMAL ELECTRONICS FOR MAPPING

An apparatus for medical diagnosis and/or treatment is provided. The apparatus includes a flexible substrate, an intermediate bus disposed on the flexible substrate, and a plurality of sensing elements disposed on the flexible substrate and coupled to the intermediate bus. The plurality of sensing elements and intermediate bus are disposed on the flexible substrate such that the sensing elements are disposed at areas of minimal strain of the flexible substrate. 1. An apparatus for medical diagnosis and/or treatment , the apparatus comprising:a flexible substrate;at least one intermediate bus disposed on the flexible substrate; and 'wherein each sensing element of the plurality of sensing elements is coupled to the at least one intermediate bus.', 'a plurality of sensing elements disposed in a close-packed array proximate to an end of the at least one intermediate bus,'}2. The apparatus of claim 1 , wherein the sensing elements are disposed at areas of minimal bending and/or flexing of the flexible substrate.3. The apparatus of claim 1 , wherein the flexible substrate is an adhesive patch or a bandage.4. The apparatus of claim 1 , wherein a measurement of the plurality of sensing elements provides a measure of an amount of contact between the inflatable body and a surface.5. The apparatus of claim 4 , wherein the surface is a portion of a tissue claim 4 , wherein a measurement from the plurality of sensing elements provides an indication of an arrhythmia condition of the tissue.6. The apparatus of claim 4 , wherein the surface is a portion of a tissue claim 4 , wherein a measurement from the plurality of sensing elements provides an indication of an artial fibrillation or a ventricular fibrillation of the tissue.7. The apparatus of claim 1 , wherein the flexible substrate forms an inflatable body claim 1 , and wherein a portion of the at least one intermediate bus is disposed about a distal region of the inflatable body.8. The apparatus of claim 7 , wherein the ...

Apparatus and method for predicting upcoming stage of carotid stenosis

An apparatus and a method predict an upcoming stage of carotid stenosis. The apparatus includes a receiving unit, a cluster determining unit, a risk factor score extracting unit, a prediction model storage unit, and a predicting unit. The method includes receiving a patient's medical test data relating to carotid stenosis; determining a cluster to which the patient's medical test data belong based on a gender of the patient; extracting from the patient's medical test data a risk factor score comprising a result of carotid stenosis ultrasonography; storing a plurality of prediction models used to predict an upcoming stage of carotid stenosis; and obtaining an outcome by applying a value indicating a stage of carotid stenosis corresponding to the result of carotid stenosis ultrasonography and the extracted risk factor score to the prediction model corresponding to the determined cluster among the plurality of prediction models.

Systems And Methods For Measuring Mitochondrial Capacity

In one embodiment, measuring mitochondrial capacity includes performing arterial occlusions on a patient, measuring oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin within the patient's body during the occlusions, calculating a blood volume correction factor that accounts for a change in blood volume that occurs during the arterial occlusions, and applying the correction factor to the measured oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements to obtain correct oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements. 1. A method for measuring mitochondrial capacity , the method comprising:performing arterial occlusions on a patient;measuring oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin within the patient's body during the occlusions;calculating a blood volume correction factor that accounts for a change in blood volume that occurs during the arterial occlusions; andapplying the correction factor to the measured oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements to obtain corrected oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin measurements.2. The method of claim 1 , wherein performing arterial occlusions comprises applying a blood pressure cuff to a limb of the patient.3. The method of claim 1 , wherein measuring oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin comprises obtaining oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin signals using a near-infrared spectroscopy (NIRS) device.4. The method of claim 3 , wherein calculating a blood volume correction factor comprises calculating a correction factor that adjusts the measured oxygenated hemoglobin/myoglobin and deoxygenated hemoglobin/myoglobin signals so that a decrease in the oxygenated hemoglobin/myoglobin signal is equivalent to an increase in the deoxygenated hemoglobin/myoglobin signal.7. The method of claim ...

Electrochemical Analyte Sensor

An electrochemical analyte sensor formed using conductive traces on a substrate can be used for determining and/or monitoring a level of analyte in in vitro or in vivo analyte-containing fluids. For example, an implantable sensor may be used for the continuous or automatic monitoring of a level of an analyte, such as glucose, lactate, or oxygen, in a patient. The electrochemical analyte sensor includes a substrate and conductive material disposed on the substrate, the conductive material forming a working electrode. In some sensors, the conductive material is disposed in recessed channels formed in a surface of the sensor. An electron transfer agent and/or catalyst may be provided to facilitate the electrolysis of the analyte or of a second compound whose level depends on the level of the analyte. A potential is formed between the working electrode and a reference electrode or counter/reference electrode and the resulting current is a function of the concentration of the analyte in the body fluid. 1. An in vivo glucose sensor , comprising:one or more working electrodes;a sensing layer proximate to at least one of the one or more working electrodes; anda mass transport limiting layer proximate to at least one of the one or more working electrodes;wherein the flexibility of the sensor is varied along a continuum of the sensor.2. The glucose sensor of claim 1 , further comprising a substrate claim 1 , wherein the varied flexibility of the sensor is based at least in part on the composition of the substrate.3. The glucose sensor of claim 1 , further comprising a substrate claim 1 , wherein the varied flexibility of the sensor is based at least in part on the thickness of the substrate.4. The glucose sensor of claim 1 , further comprising a substrate claim 1 , wherein the varied flexibility of the sensor is based at least in part on the composition and the thickness of the substrate.5. The glucose sensor of claim 1 , wherein the sensor is a planar sensor.6. The glucose ...

Artificial Tissue Systems and Uses Thereof

An implant system and a method for controlling the natural and artificial microenvironments surrounding an implanted device using an artificial tissue system (ATS) and includes methods of diagnostic and testing related thereto. The ATS, among other things, induce better integration, function, and extended lifespan of the devices at the site of implantation. The ATS includes cells, such as naturally occurring, engineered, and/or artificial cells; matrices such as natural, engineered, artificial and/or hybrid matrices; tissue response modifiers (TRM); and/or cell response modifiers (CRM). The specific composition of the ATS is based on the nature of the tissue in which ATS-device combination is implanted and the nature of the implant device, as well as the required function and lifespan of the implanted device. Additionally, the ATS, as well as ATS-device combinations can be utilized in vitro to aid in the design of improved ATS, devices and ATS-device combinations for in vivo uses. 1. A method of implanting a device in a biological tissue , comprising:obtaining an implantable device comprising a sensor having an implantable portion,forming an implantation pocket at an implantation site in the biological tissue by injecting a liquid into the biological tissue,dipping a portion of the sensor in a basement membrane, andinserting the dipped portion of the sensor into the biological tissue.2. The method of claim 1 , wherein the sensor is a glucose sensor.3. The method of claim 1 , wherein the sensor is an acetaminophen sensor.4. The method of claim 1 , wherein the basement membrane is a liquid.5. The method of claim 1 , wherein the basement membrane is a gel.6. The method of claim 1 , wherein the basement membrane is cell culture derived.7. The method of claim 1 , wherein the sensor includes a support portion claim 1 , and the method further comprises securing the support portion to the biological tissue.8. The method of claim 1 , wherein the sensor is configured to be ...

DEVICES AND METHODS FOR DETECTING ANALYTE IN BODILY FLUID

A test device for detecting an analyte in a sample of bodily fluid, includes at least one hollow needle configured to obtain a sample of bodily fluid, an enclosure configured to contain a reagent, a portion configured to open the enclosure, a test results indicator configured to absorb the bodily fluid, the test results indicator including at least one test zone configured to indicate the presence of an analyte in the bodily fluid when the at least one test zone is in fluidic contact with the reagent, a housing, and a cover configured to be movable with respect to the housing between a closed position precluding access to the at least one hollow needle and an open position permitting access to the at least one hollow needle. Additionally, the at least one hollow needle is in fluid communication with the test results indicator. 1. A test device for detecting an analyte in a sample of bodily fluid , comprising:at least one hollow needle configured to obtain a sample of bodily fluid;an enclosure configured to contain a reagent;a portion configured to open the enclosure;a test results indicator configured to absorb the bodily fluid, the test results indicator including at least one test zone configured to indicate the presence of an analyte in the bodily fluid when the at least one test zone is in fluidic contact with the reagent;a housing; anda cover configured to be movable with respect to the housing between a closed position precluding access to the at least one hollow needle and an open position permitting access to the at least one hollow needle;wherein the at least one hollow needle is in fluid communication with the test results indicator.2. The test device according to claim 1 , wherein the test results indicator is configured to indicate the presence of HIV.3. The test device according to claim 1 , wherein the at least one hollow needle has a coating comprising an anesthetic.4. The test device according to claim 1 , wherein the at least one hollow needle has a ...

Analyte Sensor with Time Lag Compensation

Methods and devices and systems for determining an analyte value are disclosed. 1. A method , comprising:determining a predetermined time period characterized with a rate of change of an analyte level below a preset threshold;defining a data set associated with a monitored analyte level within the predetermined time period;determining a sensitivity value based on the defined data set;applying the determined sensitivity value to signals associated with the monitored analyte level including the defined data set; andestimating a time constant associated with an analyte sensor used to monitor the analyte level.2. The method of wherein the preset threshold associated with the rate of change of the analyte level is characterized by a quiescent state of the signals received from the analyte sensor.3. The method of including receiving a reference data claim 1 , and applying the sensitivity value to the signals associated with the monitored analyte level based on the received reference data.4. The method of wherein the reference data includes a reference blood glucose measurement.5. The method of wherein the reference data is substantially time corresponding to one or more data in the defined data set.6. The method of including calibrating the signals associated with the monitored analyte level based at least in part on the estimated time constant.7. The method of including performing lag correction of the signals associated with the monitored analyte level based on the estimated time constant.8. The method of including calibrating the lag corrected signals to estimate the corresponding monitored glucose level.9. A computer implemented method claim 7 , comprising:calibrating analyte data associated with a monitored analyte level received from an analyte sensor based on a reference measurement;determining a lag time constant associated with the calibrated analyte data; andperforming lag correction of the calibrated analyte data based on the determined time lag constant.10. ...

SYSTEM AND METHODS FOR PROCESSING ANALYTE SENSOR DATA FOR SENSOR CALIBRATION

Systems and methods for processing sensor analyte data are disclosed, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. The sensor can be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. Reference data resulting from benchtop testing an analyte sensor prior to its insertion can be used to provide initial calibration of the sensor data. Reference data from a short term continuous analyte sensor implanted in a user can be used to initially calibrate or update sensor data from a long term continuous analyte sensor. 1. A method for calibrating a continuous analyte sensor , comprising:receiving sensor data from a continuous analyte sensor, wherein the sensor data comprises at least one sensor data point indicative of a glucose concentration in a host's interstitial fluid;receiving reference data from a reference analyte monitor, wherein the reference data comprises at least one reference data point indicative of a glucose concentration in the host's blood;determining a conversion function for converting the sensor data into estimated blood glucose values, using electronic circuitry, based on a most probable set of parameters that correlates with calibration data, wherein the most probable set of parameters is determined based on a probability analysis; andconverting the sensor data using the conversion function.2. The method of claim 1 , wherein one or more matched data pairs are inputs into the probability analysis claim 1 , wherein the matched data pairs comprise at least one sensor data point matched with at least one reference data point.3. The method of claim 1 , wherein the probability analysis is based on a probability distribution.4. The method of claim 3 , wherein the probability analysis comprises determining a maximum joint probability based on the probability distribution.5. The ...

METHOD OF MEASURING BIOLOGICAL SAMPLE PROPERTIES AND BIOLOGICAL SAMPLE PROPERTY MEASURING APPARATUS

A method of measuring biological sample properties and a biological sample property measuring apparatus is provided. A method of measuring biological sample properties includes disposing a biomaterial to contact a sensing unit, detecting a radio frequency (RF) signal flowing through the sensing unit, and obtaining an RF property indicator of the biomaterial based on the detected RF signal. 1. A method of measuring biological sample properties , the method comprising:disposing a biomaterial to contact a sensing unit;detecting a radio frequency (RF) signal flowing through the sensing unit; andobtaining an RF property indicator of the biomaterial based on the detected RF signal.2. The method of claim 1 , wherein the biomaterial is in vivo or in vitro contact with the sensing unit.3. The method of claim 1 , wherein the biomaterial comprises a fluid in continuous contact with the sensing unit while flowing through a microchannel.4. The method of claim 3 , wherein the obtaining of the RF property indicator comprises obtaining the RF property indicator iteratively from a time at which the fluid begins flowing on the sensing unit claim 3 , and detecting a change in the iteratively obtained RF property indicator in real time.5. The method of claim 1 , wherein the biomaterial comprises a biological sample claim 1 , and wherein the detecting of the RF signal is performed after a change in a state of the biological sample occurs.6. The method of claim 1 , wherein the RF property indicator comprises one or more from the group consisting of an impedance claim 1 , an inductance claim 1 , a conductance claim 1 , a capacitance claim 1 , and a frequency.7. The method of claim 1 , wherein the biomaterial comprises one or more from the group consisting of a cell claim 1 , an organelle claim 1 , a body fluid claim 1 , deoxyribonucleic acid (DNA) claim 1 , ribonucleic acid (RNA) claim 1 , blood claim 1 , plasma claim 1 , glucose claim 1 , glycated hemoglobin claim 1 , cholesterol claim 1 ...

METHOD OF USING THE DETECTION OF EARLY INCREASE IN MICROVASCULAR BLOOD CONTENT TO DISTINGUISH BETWEEN ADENOMATOUS AND HYPERPLASTIC POLYPS

The present invention, in one aspect, relates to a method for distinguishing between possible adenomatous and hyperplastic polyps using what :is referred to as “Early Increase in microvascular Blood Supply” (EIBS) that exists in tissues that are close to, but are not themselves, the abnormal tissue. 1. A method of providing an indication that a living polyp within a human body is one of a possible adenomatous polyp and a hyperplastic polyp comprising the steps of:inserting an illumination probe such that a light source within the illumination probe is disposed in a location that is at a surface of a colon and contains the polyp;illuminating, at the location, tissue of the colon and microvasculature therein with light from the light source that is emitted from the probe around the polyp;detecting interacted light that results from the step of illuminating the tissue as detected data, wherein the interacted light is obtained substantially from the light that then interacts with blood in the microvasculature that is within the tissue of the colon;estimating a least one of blood content and blood flow in the microvasculature using the detected data; andidentifying that the polyp is one of the possible adenomatous polyp and the hyperplastic polyp using the at least one of estimated blood content and blood flow, the step of obtaining including the step of determining whether there exists an increase in the at least one of estimated blood content and blood flow in the mucosal microvasculature.2. The method according to further including the step of removing the polyp if the polyp is indicated as being the possible adenomatous polyp claim 1 , while not removing the polyp if the polyp is indicated as being the hyperplastic polyp.3. The method according to further including the step of:visually examining the polyp with light if the polyp is indicated as being the possible adenomatous polyp to determineremoving the polyp if the poly is indicated as being the possible ...

INVOLUNTARY CONTRACTION INDUCED PRESSURE AS A MEDICAL DIAGNOSTIC TOOL USING INVOLUNTARY REFLEX COUGH TEST

A system and method allows diagnosis of a patient for physiological abnormality such as a neurological deficiency. An involuntary reflex cough event is induced within the patient that activates the nucleus ambiguus and medial motor cell column of the patient and stimulates involuntary cough activated paraspinal muscles in the pelvis of the patient. An electromyogram (EMG) is obtained from the involuntary cough activated paraspinal muscles while inducing involuntary reflex cough and determining its duration. The intra-abdominal pressure (IAP) is determined and the IAP is correlated with the EMG duration of the involuntary cough event within a processing device to diagnose a physiological abnormality such as a neurological deficiency within the patient. 124-. (canceled)25. A catheter , comprising:a catheter body having an outer surface and dimensioned for insertion within a urethra and into a bladder and having a first lumen configured to monitor bladder activity and a second lumen configured to fill the bladder with fluid; andat least one indicator positioned along the surface of the catheter that is configured to change color when exposed in combination to two separate urine characteristics to indicate urine leakage.26. The catheter according to wherein said two separate urine characteristics comprise a temperature of fluid above a predetermined value and a presence of urea.27. The catheter according to wherein said at least one indicator is responsive to fluid that is a temperature above about 30 degrees Celsius.28. The catheter according to wherein said catheter body includes a distal end and a sensor positioned thereat.2938-. (canceled)39. The catheter according to claim 25 , wherein said catheter includes a distal end and said at least one indicator is positioned from 11 to 14 centimeters from the distal end along the surface for female use and from 16 to 19 centimeters from the distal end for male use.40. The catheter according to claim 25 , and further ...

Systems, methods, and apparatuses for monitoring end stage renal disease

An end stage renal disease (ESRD) monitoring system may include an implantable sensor and a reader device with an optical sensor. The implantable sensor may be configured to detect a group of analytes relevant to ESRD, such as glucose, creatinine, urea, and potassium. The implantable sensor may be implanted into the dermis of an animal, and may exhibit color changes in response to the presence of the target analytes or reaction product(s) thereof. The reader device may be configured to capture an image of the implanted sensor and to determine the concentration of the target analytes based at least in part on the image. The reader device may be a personal electronic device such as a cell phone, PDA, or personal computer.

Detection Device for Detection a Blood Picture Parameter

A detection device for detecting a blood count parameter in a blood vessel, comprising a transmitter to inject a first transmit signal of a first frequency into the blood vessel and a second transmit signal of a second frequency into the blood vessel, a receiver to receive a first receive signal at the first frequency and a second receive signal at the second frequency, a loss detector to determine a first loss value on the basis of the first transmit signal and the first receive signal at the first frequency, and to determine a second loss value on the basis of the second transmit signal and the second receive signal at the second frequency, and a processor to determine a first frequency shift of the first loss value relative to a first reference loss value, determine a second frequency shift of the second loss value relative to a second reference loss value, and determine the blood count parameter on the basis of the first frequency shift and the second frequency shift. 1. A detection device for detecting a blood picture parameter of blood in a blood vessel , comprising:a transmitter, which is configured to couple a first transmission signal with a first frequency and a second transmission signal with a second frequency into the blood vessel;a receiver, which is configured to receive a first reception signal at the first frequency and a second reception signal at the second frequency; anda loss detector, which is configured to:ascertain a first loss variable on the basis of the first transmission signal and the first reception signal at the first frequency; andascertain a second loss variable on the basis of the second transmission signal and the second reception signal at the second frequency; and alsoa processor, which is configured to:ascertain a first frequency shift of the first loss variable relative to a first reference loss variable;to ascertain a second frequency shift of the second loss variable relative to a second reference loss variable; andto ...

BLOOD-CHEMISTRY IMBALANCE DETERMINATION BY MEANS OF REFLEX REACTION TIME MEASUREMENTS

A system and method are provided whereby periodic measurements of autonomic reflex times of individuals are used as an early-warning indication that an undesirable physical condition, such as an undesirable blood-chemistry condition, may exist. This method correlates measurements of the reaction times of specific autonomic reflexes to more-definitive measurements for the medical condition being monitored for this early-warning assessment. 1. A method for a processor-controlled computing device to automatically determining an adverse physiological change in a person , comprising the steps of:identifying an autonomic reflex parameter for measurement,determining a baseline range for said parameter,measuring said parameter at a predefined interval and capturing the plurality of measured data,analyzing said measured data by determining if individual measurements or the trend of said measurements is at or near the edges of said baseline range.2. The method of claim 1 , where said parameter is one in which there is a statistical relationship with changes in blood sugar.3. The method of claim 1 , wherein said parameter is one in which there is a statistical relationship with changes in blood alcohol.4. The method of claim 1 , where said measurement is at least one of pulse claim 1 , skin coloration claim 1 , eye movement claim 1 , ear movement claim 1 , or vestibulo-ocular reflex (VOR).5. The method of claim 1 , where said range is determined at least in part claim 1 , on medical history of the individual.6. The method of further comprising the step of delivering a notification of an adverse condition upon identifying individual measurements or the trend of said measurements is at or near the edges of said baseline range.7. The method of further comprising the step of claim 1 , upon determining that individual measurements or the trend of said measurements is at or near the edges of said baseline range claim 1 , taking one or more tests claim 1 , wherein said tests are ...

SYSTEM, METHOD AND COMPUTER PROGRAM PRODUCT FOR OPTICAL MEASUREMENT OF BLOOD PARAMETERS

A system for optically measuring blood parameters including a light source and light transmitter for transmitting light to the blood, a light remitter for capturing remitted light, a spectrometer breaking the remitted light into its spectral components and a processor for comparing a morphologically distinct portion of the remitted light to a database of known morphologies. Each of the known morphologies corresponds to a measurement value at least one parameter, such as an analyte. Advantageously, the determined morphologies can uniquely correspond to two or more blood parameters, such as OHb and tHb, allowing simultaneous determination of the two parameters. 1. A system for optically measuring parameters in blood , the system comprising:a light source configured to generate light having a range of spectra;a light transmitter configured to direct the generated light from the light source into the blood;a light remitter configured to receive and direct light remitted from the blood;a detector configured to receive the remitted light from the light remitter and determine a spectral composition of the remitted light; anda processor configured to determine a morphology of at least one distinct portion of the spectral composition,wherein the morphology corresponds to a known value for at least one blood parameter.2. The system of claim 1 , wherein the processor is further configured to compare the morphology to a database of known morphologies to determine the value for the at least one blood parameter.3. The system of claim 2 , wherein the database of known morphologies is defined by a reference matrix of at least three dimensions and wherein each of the known morphologies corresponds to the known value for at least two parameters.4. The system of claim 3 , wherein the three-dimensional matrix has dimensions of at least 61×467×101.5. The system of claim 4 , wherein the 467 slices of the matrix represent points between 440 nm and 540 nm.6. The system of claim 5 , wherein ...

METHOD FOR EVALUATING AND MODIFYING THE STATE OF HYDRATION OF A SUBJECT

This invention provides methods and devices for individual evaluating and modifying the state of interstitial hydration of an individual. 1. A method for determining the baseline state of the whole-body interstitial hydration (diagnostic mVLT or DmVLT) of a subject comprising:a) quantifying the subject's initial baseline generic target parameters, wherein the derivative target parameter(s) are determined from the generic target parameter(s) by the Bolus Induced Response of Deviations (BIRD) mathematical model set forth in the specification and figures, wherein the target parameter(s) are chosen from the group of arterial, venous and capillary hemoglobin concentration ([Hb]), or wherein at least arterial or capillary Hb;b) intravenously administering to the subject an iso-oncotic, iso-osmotic non-cellular liquid at the highest safe rate over a period of 2-5 minutes, wherein the total volume administered is 1.5 to 2.5 ml per kg of the subject's lean body mass;c) quantifying the subject's generic target parameter(s) after a period of 5 minutes from the end of step b), but before 6 minutes from the end of step b) without further intravenous administration of a liquid to the subject;d) determining by formulae the derivative target parameter(s) for the respective generic target parameter(s) obtained in steps a), and c);e) intravenously administering to the subject an iso-oncotic, iso-osmotic non-cellular liquid at the highest safe rate over a period of 2-5 minutes, wherein the total volume administered is 1.5 to 2.5 ml per kg of the subject's lean body mass;f) quantifying the subject's acute residual generic target parameter(s) after a period of 5 minutes from the end of step b), but before 6 minutes from the end of step e), without further administration of liquid to the subject;g) determining by formulae the derivative target parameter(s) of the respective generic target parameter(s) obtained in steps e) and g);h) comparing the derivative target parameter(s) determined ...

Methods and Apparatuses for Noninvasive Determination of in vivo Alcohol Concentration using Raman Spectroscopy

Methods and apparatuses for the determination of an attribute of the tissue of an individual use non-invasive Raman spectroscopy. For example, the alcohol concentration in the blood or tissue of an individual can be determined. A portion of the tissue is illuminated with light, which propagates into the tissue where it is Raman scattered. The Raman scattered light is detected and can be combined with a model relating Raman spectra to alcohol concentration to determine the alcohol concentration in the blood or tissue. Correction techniques can reduce determination errors due to detection of light other than that from Raman scattering from the alcohol in the tissue. Other biologic information can be used with the Raman spectral properties to aid in the determination of alcohol concentration, for example age, height, weight, medical history and his/her family, ethnicity, skin melanin content, or a combination thereof. The method and apparatus can be optimized to provide reproducible and uniform radiance of the tissue, low tissue sampling error, depth targeting of the tissue layers or sample locations that contain the attribute of interest, efficient collection of Raman spectra, optical throughput, photometric accuracy, large dynamic range, thermal stability, calibration maintenance, calibration transfer, built-in quality control, and ease-of-use. 1. An apparatus for the non-invasive in vivo determination of the concentration of alcohol , a substance of abuse , or both , in human tissue of an individual , where the tissue is not the eye , by Raman spectroscopy , comprising:(a) an illumination subsystem for generating excitation light,(b) a sampling subsystem for delivering the excitation light to a portion of the in vivo tissue and detecting light from the in vivo tissue,(c) a spectrometer subsystem for determining a Raman spectrum from the detected light(d) a computing subsystem for correcting the measured Raman spectrum, and(e) a calibration subsystem for determining ...

CONTOURED PROTRUSION FOR IMPROVING SPECTROSCOPIC MEASUREMENT OF BLOOD CONSTITUENTS

A noninvasive physiological sensor for measuring one or more physiological parameters of a medical patient can include a bump interposed between a light source and a photodetector. The bump can be placed in contact with body tissue of a patient and thereby reduce a thickness of the body tissue. As a result, an optical pathlength between the light source and the photodetector can be reduced. In addition, the sensor can include a heat sink that can direct heat away from the light source. Moreover, the sensor can include shielding in the optical path between the light source and the photodetector. The shielding can reduce noise received by the photodetector. 1. A noninvasive medical sensor configured to detect light attenuated by body tissue of a medical patient , the sensor comprising:a sensor housing comprising an upper shell and a lower shell pivotally connected together, the upper and lower shells each shaped to accept body tissue of a medical patient;one or more emitters disposed in the housing, the one or emitters configured to impinge light on the body tissue of the patient;one or more detectors disposed in the housing, the one or more detectors configured to receive the light after attenuation by the body tissue of the patient and to output one or more intensity signals responsive to the attenuated light; anda tissue thickness adjuster disposed in the housing, the tissue thickness adjuster positioned such that placement of the body tissue of the patient on the tissue thickness adjuster reduces a thickness of the body tissue and thereby increases a gain of the one or more intensity signals.2. The sensor of claim 1 , wherein the tissue thickness adjuster comprises a protrusion configured to deform the body tissue.3. The sensor of claim 2 , wherein the protrusion is a partially cylindrical protrusion.4. The sensor of claim 3 , wherein the partially cylindrical protrusion comprises a lens.5. The sensor of claim 4 , wherein the partially cylindrical protrusion ...

Methods and Systems for Processing Social Interactive Data and Sharing of Tracked Activity Associated with Locations

A method includes determining a location of a first monitoring device used while performing an activity. The first monitoring device is worn by a first user. The method includes determining a location of a second monitoring device used while performing an activity. The second monitoring device is worn by a second user. The method further includes determining whether the locations of the first and second monitoring devices are within a range and whether the activities are similar. The method includes sending a prompt to the first monitoring device upon determining that the activities are similar and the locations are within the range. The prompt includes a request for permission from a first user account to allow a second user account to access information from the first user account regarding the activity performed using the first monitoring device.

MENSTRUAL FLUID ANALYSIS

A disposable menstrual fluid fractionation apparatus for use in situ during menstruation is disclosed. The apparatus may include a filter configured to remove a particulate component of menstrual fluid from a liquid component of the menstrual fluid. A receptacle may be coupled to the filter. The filter, receptacle, and an analyte sensor may be integrated into a disposable feminine hygiene product. The integrated analyte sensor may be configured to detect a target analyte in the liquid component and indicate the presence/concentration of the target analyte. 1. A disposable menstrual fluid fractionation apparatus comprising:a porous matrix including an upstream surface with a first plurality of pores and a downstream surface with a second plurality of pores, the first and the second plurality of pores being permeable to a liquid component of a flow of menstrual fluid and the second plurality of pores being impermeable to a mammalian erythrocyte, and the average diameter of the second plurality of pores being less than the average diameter of the first plurality of pores;a receptacle coupled to the downstream surface of the porous matrix, the receptacle configured to receive a portion of the liquid component after passage of the flow of menstrual fluid through the porous matrix;a first detection reagent coupled to the porous matrix or the receptacle, the first detection reagent configured to interact with one or more second detection reagents of an analyte sensor to detect a target analyte in the liquid component; anda positioning element coupled to the porous matrix, the positioning element configured to retain the porous matrix in proximity to a flow of menstrual fluid, wherein the disposable menstrual fluid fractionation apparatus is configured to be coupled to a feminine hygiene product.2. The disposable menstrual fluid fractionation apparatus of claim 1 , wherein the first detection reagent comprises one or more of an antibody claim 1 , an aptamer claim 1 , or an ...