СПОСОБ ОЦЕНКИ ПОВРЕЖДЕНИЯ МЫШЦ ДИАФРАГМЫ ТАЗА И ЗОНД И УСТРОЙСТВО ДЛЯ РЕАЛИЗАЦИИ СПОСОБА

Группа изобретений относится к медицине, а именно к устройствам и способам оценки травмы мышц диафрагмы таза. При этом вводят зонд в прямую кишку. Генерируют с использованием генератора электрические сигналы постоянной амплитуды и подводят их к мышцам диафрагмы таза при помощи подводящих электродов (ЕА1) и (ЕА2). Обнаруживают сигналы электрического напряжения от мышц диафрагмы таза с помощью измерительных электродов (EP1), (EP2)... (EP6). Анализируют сигналы электрического тока и напряжения для амплитудных значений и фазовых зависимостей их формы сигнала. При этом сигнал электрического тока и сигналы электрического напряжения от мышц тазового дна составляют сигналы, изменяющиеся по времени, частот в диапазоне от 2 до 200 кГц. Измерительный зонд для оценки повреждения мышц диафрагмы таза содержит цилиндрический основной корпус, два подводящих электрода и измерительные электроды. Измерительные электроды расположены на поверхности зонда. Каждый электрод имеет электрический контакт, проходящий ...

СПОСОБ ЛЕЧЕНИЯ ЖЕЛУДОЧНО-КИШЕЧНОГО РАССТРОЙСТВА ПОСРЕДСТВОМ УСТРОЙСТВА ДЛЯ НЕЙРОСТИМУЛЯЦИИ

... 1. Применение устройства для нейростимуляции в качестве средства для лечения желудочно-кишечного расстройства, при котором по крайней мере один электрод вышеупомянутого устройства соединяют с вегетативным нервом и подают электрический сигнал на по крайней мере часть упомянутого вегетативного нерва, при этом вегетативный нерв включает в себя внутренний нерв грудного отдела и часть блуждающего нерва, выбранной из группы, включающей пищеводное сплетение, мышечно-кишечное сплетение Ауэрбаха, подслизистое сплетение Мейсснера, основной нерв малой кривизны желудка и желудочная ветвь блуждающего нерва. ! 2. Применение по п.1, в котором дополнительно используют программируемый генератор электрического сигнала, который соединяют с упомянутым по крайней мере одним электродом. ! 3. Применение по п.2, в котором в упомянутом генераторе электрического сигнала формирование упомянутого сигнала производят по группе параметров, включающей величину тока, широту импульсов, частоту импульсов, время нахождения ...

SURFACE VIBRATION ANALYSIS

Apparatus for use in therapy

DEVICE FOR THE MEASUREMENT OF THE DIFFERENCE OF POTENTIAL OF THE INTESTINE

TONOMETRI CATHETER DEVICE AND PROCEDURE WITH REMOTE SENSOR

TONOMETRI CATHETER COMBINATION

DEVICE FOR THE TELEMETERING OF MEANS OF A PRINTING MEASURING CATHETER

Temperature activated vibrating capsule for gastrointestinal treatment

A vibrating ingestible capsule includes a housing having a longitudinal axis, and having a vibrating agitation mechanism adapted such that, in a first vibrating mode of operation, the housing exerts vibrations on an environment surrounding the capsule. A power supply disposed within the housing is adapted to power the vibrating agitation mechanism. A temperature sensor provides temperature information signals with respect to a temperature in an environment surrounding the vibrating ingestible capsule over a period of time. A control element is adapted to receive the temperature information signals from the temperature sensor, to identify a current temperature-overtime pattern based on the temperature information signals received from said temperature sensor, to compare the current temperature-over-time pattern to a predetermined temperature-over-time pattern, and, after the current temperature-overtime matches the predetermined temperature-over-time pattern, to activate the vibrating agitation ...

Swallowable capsule, system and method for measuring gastric emptying parameters

Gastrointestinal pacemaker

System for treating a patient having an intestinal disorder

Device for detecting and indicating the preparatory phase of birthing a bovine or equine animal, and corresponding method and computer program product

The invention concerns a device and method for detecting and indicating the preparatory phase of birthing a bovine or equine animal, that can be secured to the tail of said bovine or equine animal. According to the invention, such a detection and indication device comprises: -means for measuring the components of acceleration of said device according to at least one axis, and preferably according to three orthogonal axes; -means for processing the measurements of said components, intended to detect an occurrence of said preparatory phase; -means for generating a radio communication signal configured so as to generate said signal in case said occurrence is detected; -means for transmitting said generated signal to a collector forming a relay or to a terminal.

Capsule with strain gauge sensors to sense events in the gastrointestinal tract

A capsule for examining the gastrointestinal tract, including, a capsule shell enclosing the capsule, wherein said capsule shell is designed to be swallowed by a user to traverse the user's gastrointestinal tract internally, a strain gauge coupled to the capsule shell for measuring strain forces exerted on the capsule shell, a control for receiving the measurements from the strain gauge and responding to the measurements.

An analyzing apparatus and method

SYSTEM FOR TREATING A PATIENT HAVING AN INTESTINAL DISORDER

Implantable artificial intestine section to be connected to a surgically created opening in the patient's intestine comprises an accumulator for accumulating energy. The accumulator is adapted to be charged wirelessly with energy and is arranged to supply energy directly or indirectly to at least one energy consuming part of the artificial intestine section, such as a flow control device, a pump, a motor, a control unit and a sensor.

GASTROINTESTINAL TRACT DETECTION METHODS, DEVICES AND SYSTEMS

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

GASTROINTESTINAL TRACT DETECTION METHODS, DEVICES AND SYSTEMS

The present disclosure relates to gastrointestinal (GI) tract detection methods, devices and systems.

GAS SENSOR CAPSULE

A capsule adapted to be introduced into the digestive system and gastrointestinal (Gl) tract of a mammal which consists of a capsule shaped container consisting of a wall material capable of being bio compatible with the digestive system and being adapted to protect the electronic and sensor devices contained in the capsule. The capsule contains gas composition sensors operable at several temperature points for a short duration, a temperature sensor, a micro controller, a power source and a wireless transmission device. The capsule wall incorporates gas permeable membranes adjacent said gas sensors. The microprocessor is programmed to receive data signals from the sensors and convert the signals into gas composition and concentration data and temperature data suitable for transmission to an external computing device.

SWALLOWABLE CAPSULE, SYSTEM AND METHOD FOR MEASURING GASTRIC EMPTYING PARAMETERS

Embodiments provide devices, systems and methods for measuring a gastric emptying (GE) parameter (GEP). Many embodiments provide a swallowable capsule having three electrodes one covered by a coating which remains in the stomach but is degraded in the small intestine (SI). The electrodes are coupled to circuitry such that when the capsule is in the stomach, current flow occurs between the first two electrodes generating a first signal and in the SI current flow occurs between the second and now uncovered third electrode generating a second signal. These two signals can be transmitted and analyzed externally or by an internal controller to determine a GEP e.g., GE time. The patient may wear an external device configured to receive and analyze the signals to determine GE time. Embodiments of the invention may be used to diagnose gastroparesis and provide patients information on when to eat meals or administer insulin after eating.

LOCALIZATION SYSTEMS AND METHODS FOR AN INGESTIBLE DEVICE

Ingestible devices are disclosed that provide very high localization accuracy for the devices when present in the GI tract of a body. Related systems and methods are also disclosed.

POLYP TRAP

A polyp trap may comprise an upper and lower housing, and a porous separating disk. The upper housing may be domed with a top view window for viewing tissue retained by the disk. The disk is seated in the lower housing and may be held in place by the upper housing, when the upper housing is coupled to the lower housing. The upper and lower housings are coupled using interlocking flange members extending from the walls of the upper housing and the lower housing. In one example, the upper housing holds the disk in place by engaging a post, which doubles as a handle for removing tissue from the disk and transferring the tissue to a storage container or bag. Alternatively, a peripheral portion of the disk or both of these may be used for securing the disk in the trap. Mating posts in the lower housing may engage guide holes in the disk to further secure the disk in the trap.

ESTIMATION DEVICE, PROGRAM, ESTIMATION METHOD, AND ESTIMATION SYSTEM

Includes an extraction unit that extracts first information on a physiological state of a subject and second information on at least one of an emotion and organ activity of the subject from information on a physiology of the subject; a calculation unit that obtains a degree of similarity between changes over time indicated by the first information and the second information which are extracted and calculates a shift amount from a predetermined state in which a homeostasis in the subject is maintained based on the obtained degree of similarity; and an estimation unit that estimates a pathology of the subject based on the calculated shift amount.

METHODS AND DEVICES FOR DETECTING BOWEL PERFORATION

The present disclosure relates to methods and devices to detect perforation of the bowel, for example, resulting from surgical procedures, such as laparoscopy, diagnostic procedures, such as colonoscopy, medical conditions, such as diverticulitis, and trauma. The present disclosure also relates to filtration systems and electrical connector assemblies for use in the methods and devices.

COLLECTOR FOR HUMAN FECES

The present invention relates to a collector for human feces, consisting of: a fixing plate (100) comprising a C-shaped left plate (101) and a C-shaped right plate (101') of which the ends are connected to each other so as to have a penetrated central portion and be folded over each other; a feces collection bag (200) of which the end is fixed to one lateral side of the fixing plate (100), and which ordinarily is rolled to be inserted between the folded C-shaped left plate (101) and C-shaped right plate (101') of the fixing plate (100), and is pushed out from a penetrated hole of the fixing plate (100) when feces is injected; and an adhesion means (300). Since the feces collection bag does not come in contact with the anus when worn on the anus, the good wearing sensation can ease defecation.

CAPSULE WITH STRAIN GAUGE SENSORS TO SENSE EVENTS IN THE GASTROINTESTINAL TRACT

A capsule for examining the gastrointestinal tract, including, a capsule shell enclosing the capsule, wherein said capsule shell is designed to be swallowed by a user to traverse the user's gastrointestinal tract internally, a strain gauge coupled to the capsule shell for measuring strain forces exerted on the capsule shell, a control for receiving the measurements from the strain gauge and responding to the measurements.

DEVICE FOR DETECTING AND INDICATING THE PREPARATORY PHASE OF BIRTHING A BOVINE OR EQUINE ANIMAL, AND CORRESPONDING METHOD AND COMPUTER PROGRAM PRODUCT

The invention concerns a device and method for detecting and indicating the preparatory phase of birthing a bovine or equine animal, that can be secured to the tail of said bovine or equine animal. According to the invention, such a detection and indication device comprises: -means for measuring the components of acceleration of said device according to at least one axis, and preferably according to three orthogonal axes; -means for processing the measurements of said components, intended to detect an occurrence of said preparatory phase; -means for generating a radio communication signal configured so as to generate said signal in case said occurrence is detected; -means for transmitting said generated signal to a collector forming a relay or to a terminal.

SYSTEMS AND METHODS FOR PREVENTION OF GASTRO - INTESTINAL DISORDER

Apparatus for detecting axial force in the digestive system

PROBE CAPTRICE OF MANOMETRY ANO-RECTALE HAS THREE SMALL BALOONS AND DEVICE Of BLOWING AND MEASUREMENT FOR SA STARTING.

APPAREILLAGE POUR L'EXECUTION TELECOMMANDEE D'EXAMENS MEDICAUX, NOTAMMENT RADIOLOGIQUES, DE CAVITES PHYSIOLOGIQUES

UNE MEME ELECTROPOMPE 1-2 EST UTILISEE POUR INSUFFLER DE L'AIR COMPRIME (CIRCUIT5) ET POUR INTRODUIRE LE PRODUIT DE CONTRASTE (CIRCUIT6), CES DEUX CIRCUITS ABOUTISSANT A UNE CANULE A DOUBLE FLUX 7. LA COMMANDE DE LA CIRCULATION DE L'AIR COMPRIME ET DES DISPOSITIFS ASSOCIES EST OPEREE A L'AIDE D'ELECTROVANNES 8, 13, 20, 21 ALIMENTES PAR DES RELAIS 3, 9, 14, 22, 23 PLACES SOUS LA DEPENDANCE D'ORGANES DE MANOEUVRE 24 ELOIGNES DE LA TABLE QUI PORTE LE SUJET A EXAMINER.

DEVICE, METHOD AND PROGRAM MONITORING TISSUE PERFUSION

L'invention concerne un dispositif (1) de monitorage de perfusion d'un tissu d'un organe (3), comprenant - un capteur de perfusion (2) configuré pour détecter une perfusion du tissu, et - au moins un capteur d'activité (4) configuré pour détecter une activité musculaire de l'organe (3), ledit au moins un capteur d'activité (4) étant disposé à proximité du capteur de perfusion (2), lesdits capteurs étant configurés pour être associés à une unité de traitement (5). L'invention concerne en outre un procédé et programme de monitorage associés.

RFID DEVICE ADAPTED TO BE INGESTED, SENSOR ASSEMBLY AND SYSTEM THEREFOR

Equipment for carrying out medical examinations, in particular X-ray examinations, of physiological cavities by remote control

추정장치, 프로그램, 추정방법 및 추정시스템

... 피험자의 생리를 나타내는 정보로부터, 피험자의 생리상태를 나타내는 제1 정보와 피험자의 감정 및 기관의 활동의 적어도 한쪽을 나타내는 제2 정보를 추출하는 추출부와, 추출한 제1 정보와 제2 정보가 나타내는 시간 변화에 있어서의 유사 정도를 구하고, 구한 유사 정도에 근거하여 피험자에 있어서의 항상성이 유지된 소정 상태로부터의 어긋남량을 산출하는 연산부와, 산출된 어긋남량에 근거하여 피험자의 병의 상태를 추정하는 추정부를 가진다.

DEVICE, SYSTEM AND METHOD FOR IN-VIVO DETECTION OF BLOOD IN GASTROINTESTINAL FLUIDS

In-vivo devices, systems and methods can be for the detection of blood within in-vivo fluids. The in-vivo devices include a gap or passage, which remains in contact with bodily fluids, and through which the fluids pass when the device is in-vivo. The devices further include illumination sources on a first side of the gap or passage for irradiating in-vivo fluids that pass through the gap or passage. The devices further include a light detector positioned on a second side of the gap/passage opposite to the first side and facing the illumination sources, for detecting light from the illumination sources that passes through the in-vivo fluids.

DEVICE, SYSTEM AND METHOD FOR MEASUREMENT AND ANALYSIS OF CONTRACTILE ACTIVITY

A method and system for determining intestinal dysfunction condition are provided by classifying and analyzing image frames captured in-vivo. The method and system also relate to the detection of contractile activity in intestinal tracts, to automatic detection of video image frames taken in the gastrointestinal tract including contractile activity, and more particularly to measurement and analysis of contractile activity of the GI tract based on image intensity of in vivo image data.

PROCESS AND SENSOR FOR DETECTING STRUCTURAL CONDITIONS IN A LIVING ORGANISM

To detect, for example, the arrival of stools in the intestine, the electrical conditions (9) in the intestine are monitored by applying a voltage by means of a capacitative coupling (15) and electrodes (3e and 5e) to the electrolytic section (9) formed by the intestine, and the resultant current (I) is measured.

METHOD AND APPARATUS FOR MEASURING OF INTESTINAL POTENTIAL DIFFERENCE

L'invention concerne un procédé et un appareil servant à générer un signal de différence de potentiel (DP) à travers la muqueuse, ledit signal n'étant pratiquement pas affecté par les activités motrices intestinales, et ce grâce à la réduction du signal DP sur la base des variations dans le temps du signal de pression intraluminale (PI). L'invention concerne également de différentes applications de ce signal telles que la mesure de la résistance périphérique globale, la détection d'anomalies dans le système nerveux entérique et la détection de lésions dans la barrière muqueuse.

Biofeedback apparatus for use in therapy

Apparatus and a program designed to train the user to control one or more aspects of his or her psycho-physiological state is controlled by signals representative of a psycho-physiological parameter of the user, e.g. galvanic skin resistance. This may be detected by a sensor unit with two contacts on adjacent fingers of a user. The sensor unit can be separate from a receiver unit which is connected to a computer running the program. The apparatus is described for use in treating patients with a physiological condition, for example, irritable bowel syndrome. In a treatment session, one or more psycho-physiological parameters of the patient is sensed and the sensed parameter used to alter a display which the patient watches. The display includes a visual or pictorial representation of the physiological condition being treated which changes in appearance in a fashion corresponding to the physiological change desired in the patient.

Tactile control device for a remote sensing device

The remote sensing device is added to a fibro-optic illuminating and viewing system such as a colonoscope. The directional sensing device is located in a flexible hood surrounding the distal end of the fiberscope. The sensor devices located in the hood at close spacings consist of semiconductive digital foam sheath with electrodes located on its inside surface. The sheath and electrodes are attached to an ohmmeter so that when the instrument contacts with the wall, e.g. of a colon, the pressure is measured. The completed circuit forms a signal which is used to direct the distal end of the fiberscope in a direction away from the point of greatest resistance so as to follow the lumen with greater safety. Contacts may also be positioned along the length of the endoscope so as to be activated by tension below the level of pressure required to disrupt the intestinal wall, or when used in other applications, at a level of pressure appropriate to that use.

Surgical tissue monitoring system

A tissue monitoring system includes an introducer having an inflatable section and a plurality of electrodes disposed thereon. The electrodes are alternatively connected to an electrode contact system which includes at least one signal line and at least one measurement line for taking readings about a circumferential segment of tissue encompassed by the electrodes.

BOWEL SOUND ANALYSIS METHOD AND SYSTEM

A bowel sound analysis method and system utilizes an audio collection apparatus to continuously monitor an abdominal cavity of an examinee and collect a bowel sound signal of an intestinal tract inside the abdominal cavity, converts the bowel sound signal into a digital signal, then removes noise from the digital signal by using higher-order statistics (HOS) and captures a high-complexity feature from the digital signal by using fractal dimension algorithm, and subsequently defines the high-complexity feature as an intestinal motility signal. The refore, according to the intestinal motility signal, a time point when intestinal motility occurs in the intestinal tract inside the abdominal cavity of the examinee can be learned, and bowel sound features such as the amplitude, frequency, and period of the intestinal motility signal may further be analyzed to determine a health condition of the intestinal tract.

Impedance techniques in tissue-mass detection and characterization

A device is described for measuring electrical characteristics of biological tissues with plurality of electrodes and a processor controlling the stimulation and measurement in order to detect the presence of abnormal tissue masses in organs. Examples of suitable organs are the breast, skin, oral cavity, lung, liver, colon, rectum, cervix, and prostate and determine probability of tumors containing malignant cancer cells being present in tissue. The approach can also be applied to biopsied tissue samples. The device has the capability of providing the location of the abnormality. The method for measuring electrical characteristics includes placing electrodes and applying a voltage waveform in conjunction with a current detector. A mathematical analysis method is then applied to the collected data, which computes spectrum of frequencies and correlates magnitudes and phases with given algebraic conditions to determine mass presence and type.

Guidance device and capsule medical device guidance system

A guidance device includes: a magnetic field generation unit configured to generate the magnetic field; a movement mechanism configured to move the magnetic field generation unit in a vertical direction; a rotation mechanism configured to rotate the magnetic field generation unit in a vertical plane including a magnetization direction of the magnetic field generation unit; an input unit configured to input first operation information for changing posture of a capsule medical device; and a control unit configured to: cause the rotation mechanism to rotate the magnetic field generation unit to change the posture of the capsule medical device based on the first operation information; and control the movement mechanism to change a distance between the magnetic field generation unit and the capsule medical device to correct a magnetic attracting force in a vertical direction of the capsule medical device.

INTRALUMINAL PRESSURE DETECTION FOR DIVERTICULAR DISEASE

A pressure detection tablet is disclosed. The tablet is a capsule including a dye encapsulated within an inner coating, in which the inner coating is configured to rupture at a pressure equal to or greater than a pressure threshold. The tablet further includes an outer coating surrounding the capsule, in which the outer coating is configured to provide delivery of the capsule to a targeted site. The dye may be a non-metabolized, water soluble dye, such that a ruptured capsule releases the dye which can be visually detected in the urine. In some embodiments, the disclosure provides a method of making the tablet, using the tablet to detect peak pressure in the colon and reducing the risk of developing a colonic disorder.

SYSTEMS AND METHODS FOR PREDICTING GASTROINTESTINAL IMPAIRMENT

Predicting gastrointestinal impairment may involve obtaining intestinal sounds of a patient to generate audio data, identifying predefined spectral events in the audio data that are predictive of subsequent gastrointestinal impairment, the spectral events being defined by predefined parameters, and predicting the likelihood of subsequent gastrointestinal impairment relative to the identified spectral events.

SYSTEMS, DEVICES AND METHODS FOR PERFORMING MEDICAL PROCEDURES IN THE INTESTINE

A method for performing a medical procedure in an intestine of a patient is provided. The method comprises providing a system comprising: a catheter for insertion into the intestine, the catheter comprising: an elongate shaft comprising a distal portion; and a functional assembly positioned on the shaft distal portion and comprising at least one treatment element. The catheter is introduced into the patient, and target tissue is treated with the at least one treatment element. The target tissue comprises mucosal tissue of the small intestine, and the medical procedure can be configured to treat at least one of non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH). 1. A method for performing a medical procedure in an intestine of a patient , comprising:providing a system comprising:a catheter for insertion into the intestine, the catheter comprising:an elongate shaft comprising a distal portion; anda functional assembly positioned on the shaft distal portion and comprising at least one treatment element;introducing the catheter into the patient; andtreating target tissue with the at least one treatment element, wherein the target tissue comprises mucosal tissue of the small intestine;wherein the medical procedure is configured to reduce liver fat in the patient.2. The method according to claim 1 , wherein the medical procedure is further configured to reduce and/or prevent fibrosis of the liver.3. The method according to claim 1 , wherein the medical procedure is further configured to treat Type 2 diabetes.4. The method according to claim 1 , wherein the medical procedure is further configured to treat a disease or disorder selected from the group consisting of: Type 2 diabetes; Type 1 diabetes; “Double diabetes”; gestational diabetes; hyperglycemia; pre-diabetes; impaired glucose tolerance; insulin resistance; and combinations thereof.5. The method according to claim 1 , wherein treating target tissue modifies at least one of (1) nutrient ...

SYSTEMS AND METHODS FOR DIAGNOSING AND/OR TREATING GASTROINTESTINAL CONDITIONS

A medical tool for use with an endoscopic capsule includes: a jaw assembly configured to maintain the endoscopic capsule at a certain position or within a range of positions relative to the jaw assembly while the endoscopic capsule is inside a bodily lumen, the jaw assembly having a first jaw and a second jaw, the first jaw having a first portion and a second portion that is opposite from the first portion; and a control configured to move at least one of the first jaw and the second jaw from a first configuration in which the first and the second jaws are spaced at a first distance, to a second configuration in which the first and the second jaws are spaced at a second distance that is less than the first distance.

METHOD AND DEVICE FOR THE ASSESSMENT OF BOWEL FUNCTION

SYSTEMS AND METHODS FOR PREDICTING GASTROINTESTINAL IMPAIRMENT

Apparatus for measuring electrical characteristics of tissue

MEASUREMENT OF ELECTRIC CHARACTERISTICS OF TISSUE

PROBLEM TO BE SOLVED: To provide a measurement system inside an organism roughly and especially a device for the internal measurement of electric characteristics in a biological lumen. SOLUTION: This device is provided with an autonomous capsule provided with an outer surface with an opening, plural electrodes arranged inside the opening and a processor for communicating with the plural electrodes so as to generate the electric characteristics. COPYRIGHT: (C)2002,JPO ...

Способ прогнозирования развития выраженного синдрома низкой передней резекции

Изобретение относится к медицине, а именно к онкологии, хирургии и колопроктологии. Пациентам до начала лучевой терапии и через 8 недель после лучевой терапии проводят аноректальную манометрию высокого разрешения с определением максимального давления сжатия, мм рт.ст., и объема первого ощущения, мл. При снижении максимального давления сжатия на 30% и более от исходного уровня и при повышении объёма первого ощущения на 60% и более от исходного уровня прогнозируют развитие выраженного синдрома низкой передней резекции через 3 месяца после закрытия илеостомы. Способ информативен, малоинвазивен, позволяет выделять группы больных с высоким риском развития выраженного синдрома низкой передней резекции (СНПР) для осуществления их тщательного наблюдения с целью своевременного проведения адекватных профилактических и реабилитационных мероприятий, что улучшит социальную адаптацию пациентов. 3 табл., 2 пр.

СПОСОБ ОЦЕНКИ ПОВРЕЖДЕНИЯ МЫШЦ ДИАФРАГМЫ ТАЗА, И ЗОНД И УСТРОЙСТВО ДЛЯ РЕАЛИЗАЦИИ СПОСОБА

Vorrichtung zur Druckmessung in einem Fluid

Die vorliegende Erfindung betrifft eine Vorrichtung zur Druckmessung in einem Fluid bestehend aus einem Kopplungselement, wenigstens einem Druckwandler und wenigstens eine, mit einem Fluid befüllbaren Messkammer, wobei die Messkammer über eine Membran mechanisch mit der Messfläche des Druckwandler gekoppelt ist und die Messkammer wenigstens zwei Anschlussstellen für einen Fluidstrom aufweist. Die Erfindung ist dadurch gekennzeichnet, dass der wenigstens eine Druckwandler in dem Kopplungselement angeordnet ist, und die wenigstens eine Messkammer zwei gegenüberliegende äußere Stege aufweist, wobei einer der Stege in eine Klemmkante des Kopplungselementes eingreift, und der andere Steg in eine Andruckwalze eingreift, wobei die Andruckwalze drehbar gelagert und kraftschlüssig mit der Kopplungseinheit verbindbar ist. Darüber hinaus umfasst die Erfindung auch eine entsprechende Messkammer für die Verwendung ein einer entsprechende Vorrichtung zur Druckmessung.

TONOMETRISCHE KATHETER-KOMBINATION

DEVICE FOR THE TELEMETERING OF MEANS OF A TONOMETRIE CATHETER

Sizing device for sizing an opening in a hollow body organ

Diagnostic capsule and method of use

METHODS AND DEVICES FOR DETECTING TISSUE CELLS

Estimation of distances and size of lesions in the colon with an imaging capsule

A method of estimating distances in a colon of a subject, including: orally administering to a subject a contrast agent, orally administering an imaging capsule to the subject, emitting radiation from the imaging capsule at a location in the colon, detecting photons that are returned from an interaction of the radiation with an inner wall of the colon and contents of the colon, summating the detected photons with energies corresponding to X-ray florescence interactions to form a first count, summating the detected photons with energies corresponding to Compton back-scattering interactions to form a second count, determining the distance from the imaging capsule to the inner wall of the colon and a concentration of the contrast agent at the location of the imaging capsule in the colon using the values of the first count and the second count.

IDENTIFYING DIFFERENT TYPES OF PAIN USING MAGNETIC RESONANCE SPECTROSCOPY

The present invention relates to a method and system for using neurochemical markers to identify different types of pain, including chronic and acute, and providing the capacity to monitor response to therapy on an individual basis. The present invention relates to a method and system for using neuro biomarkers to identify pain of different types and origins, and the capacity to monitor response to therapy on a personalized basis.

Systems and methods of a health monitoring device

Disclosed are systems and methods of a health monitoring device comprising: a flexible circuit, an absorbent product, and, a processing unit. The flexible circuit comprises: an electrochemical biosensor, a color sensor, an LED, and, a moisture sensor. The electrochemical biosensor comprises a plurality of reference electrodes. The processing unit comprises: a GPS antenna, a power unit, a bluetooth low energy transceiver, a GPS transceiver, a microcontroller, and, an accelerometer. The processing unit is electronically coupled to the flexible circuit. The methods comprise: obtaining health data from health monitoring device; recording the health data on the memory unit; transmitting the health data to a data communication device; and, displaying the health data on the data communication device.

Methods and devices for detecting bowel perforation

The present disclosure relates to methods and devices to detect perforation of the bowel, for example, resulting from surgical procedures, such as laparoscopy, diagnostic procedures, such as colonoscopy, medical conditions, such as diverticulitis, and trauma. The present disclosure also relates to filtration systems and electrical connector assemblies for use in the methods and devices.

METHOD AND APPARATUS FOR MEASURING OF INTESTINAL POTENTIAL DIFFERENCE

The present invention relates to a method and an apparatus for producing a transmucosal potential difference (PD) signal essentially being unaffected by intestinal motor activities. This is accomplished by reducing the PD signal based on time variations in the intraluminal pressure (IP) signal. The invention also relates to different applications of such a signal, such as measurement of the total peripheral resistance (TPR), detection of abnormalities in the enterical nervous system, detection of damages in the mucosal barrier.

SYSTEM FOR RECOGNITION OF BIOLOGICAL ALTERATION IN HUMAN TISSUES

The present invention is directed to a system for recognition of biological alteration in human tissues using electromagnetic waves in the microwave range, the device comprising: a transmitter device (100) comprising at least one transmitting antenna (101), a transmitter (102), and a power supply (103); a receiving device (200) comprising at least one receiving antenna (201), a receiver (202), a pre-processing module (204), and a power supply (203); a microprocessor (301; 104) and a display (302; 105); wherein the transmitter device (100) and the receiving device (200) are configured to operate at a frequency comprised between 2.0 GHz and 3.0 GHz. In a preferred embodiment, the operating frequency is comprised between 2.3 GHz and 2.5 GHz, and the device is suitable for the detection of a cancer in the human body, for example for the screening of prostate cancer, colorectal cancer, breast cancer, thyroid cancer. The device according to the invention is capable of high sensitivity and accuracy ...

ENHANCED DETECTION AND ANALYSIS OF BIOLOGICAL ACOUSTIC SIGNALS

Devices and methods for predicting risk and likelihood of post-operative gastrointestinal impairment based on regression analysis of multiple spectral events related to intestinal sounds, with decreased or eliminated falsely elevated values of those events due to ambient noise.

SYSTEMS, METHODS AND DEVICES FOR PREDICTING AND DETECTING POSTOPERATIVE COMPLICATIONS

A monitoring device includes an input port attachable for fluid communication with a catheter, the catheter for insertion in a body of a user, for receiving fluid from the body of the user, an output port, generally parallel to the input port, in fluid communication with a fluid reservoir, a fluid channel defining fluid communication between the input port and the output port, and a biosensor for continuously measuring bio-signal data of the fluid in the fluid channel, the biosensor including an electrode pair. The biosensor is in communication with a computing device for determining a condition of the user based at least in part on the bio-signal data.

NON-INVASIVE COLON MOTILITY MONITORING SYSTEM

A non-invasive colon motility monitoring system comprises an electrobioimpedance unit, an electromyography unit, and a computing device. The electrobioimpedance unit measures an impedance of a body of a subject and communicates an impedance signal that varies according to the measured impedance. The electromyography unit measures an electric voltage of the body of the subject and communicates a voltage signal that varies according to the measured voltage. The computing device includes a processing element programmed to receive the impedance signal and determine impedance data from the impedance signal, receive the voltage signal and determine voltage data from the voltage signal, compute impedance derivative data from the impedance data, compute a correlation between any two of the impedance data, the voltage data, and the impedance derivative data, determine when a bowel event is about to occur based on the correlation, and provide an indication of the bowel event.

COHERENCE GATED PHOTOACOUSTIC REMOTE SENSING (CG-PARS)

A coherence gated photoacoustic remote sensing system for imaging a subsurface structure in a sample with optical resolution may include an excitation beam source configured to generate an excitation beam that induces ultrasonic signals in the sample at an excitation location; an interrogation team source configured to generate an interrogation team incident on the sample at an interrogation location, a portion of the interrogation beam returning from the sample that is indicative of the generated ultrasonic signals, the interrogation beam being a low-coherent beam; an optical system that focuses the excitation beam onto the sample at an excitation location, and focuses the interrogation beam onto the sample at an interrogation location, at least the interrogation location being below the surface of and within the sample; and a low coherence interferometer that isolates a returning portion of the interrogation beam that corresponds to an interrogation event of the sample.

SYSTEM AND METHOD FOR ASSESSING PERFUSION IN AN ANATOMICAL STRUCTURE

The present disclosure relates to a system for measuring and assessing hemodynamics in an anatomical structure of a subject, and a method for image processing hemodynamics in at least a part of an anatomical structure in video images acquired from a subject. In particular the present disclosure relates to measuring and assessing hemodynamics in, around and near the surface, in particular the gastrointestinal wall, of the gastrointestinal tract of a subject. One embodiment discloses a method for image processing hemodynamics in at least a part of an anatomical structure in video images acquired from a subject, comprising the steps of: performing image analysis of at least one video sequence acquired after a fluorescent contrast agent has been supplied to the subject, calculating intensity values in one or more regions of interest based on the image analysis, and determining the perfusion slope of the flow of the fluorescent contrast agent through at least one of said regions of interest.

IMMUNOASSAY METHOD FOR THE DIAGNOSIS OF GASTRIC INTESTINAL METAPLASIA ASSOCIATED WITH GASTRIC CARCINOMA

This invention pertains to an in vitro immunoassay method for diagnosing human gastric intestinal metaplasia which comprises the steps of (a) contacting a gastric tissue sample of a subject suspected of having human gastric intestinal metaplasia cells with the monoclonal antibody DAS-1, or a fragment thereof, which monoclonal antibody is produced by the hybridoma deposited under ATCC accession number HB 9397 and which reacts with human gastric intestinal metaplasia antigen; and (b) detecting immunoreactivitybetween the gastric tissue and the monoclonal antibody, such inmunoreactivity indicating a positive diagnosis of human gastric intestinal metaplasia. This invention also pertains to an in vivo immunoassay method for diagnosing human gastric intestinal metaplasia which comprises the steps of (a) administering to a human, suspected of having human gastric intestinal metaplasia, the monoclonal antibody DAS-1, or a fragment thereof, which monoclonal antibody is produced by the hybridoma ...

DEVICE SUITABLE FOR BEING INGESTED AND ASSOCIATED SYSTEM

Dispositif (1), adapté pour être ingéré par un patient, comprenant une matrice (12) à délitement au niveau d'un segment digestif et une pluralité de marqueurs RFID (11) passifs, indépendants et logés ensemble dans la matrice (12) à délitement, la matrice (12) à délitement étant conformée pour qu'une fois délitée, les marqueurs RFID (11) soient séparés les uns des autres et ne soient plus mécaniquement connectés, de sorte que chaque marqueur RFID (11) puisse être déplacé indépendamment des autres marqueurs RFID (11) dans plusieurs segments du système digestif du patient,les marqueurs RFID (11) présentant chacun, dans la matrice (12) à délitement, une protection hermétique par encapsulation dans un matériau biocompatible.

APPARATUS AND METHOD FOR USE IN ANALYZING A PATIENT'S BOWEL

An apparatus and method are provided for use in studying a patient's bowel which combines recording and analysis of physiologic parameters and patient sensory perception. A pain input detector, a pain transducer, and a processor are provided. A gas pressure transducer and flow meter may also be provided. Output data may be generated to reflect perceived patient pain, volume of gas delivered to the patient's bowel, and bowel pressure. An indication of perceived patient pain is processed by the processor to generate data that may used to validate a scan of a patient or may be used as a diagnostic tool.

LABOR MANAGEMENT DEVICES FOR DECREASING THE INCIDENCE OF CESAREAN CHILDBIRTH

The present disclosure provides devices for decreasing the incidence of Cesarean childbirth by managing the labor process. In one aspect, a tactile feedback device is positioned adjacent the perianal tissues. A perianal support device includes a perianal support member having a pressure surface configured for engagement with tissue adjacent an anal orifice and a pressure detecting system associated with the perianal support member to detect pressure indicative of pressure on the perianal tissue of a patient.

A Percutaneously Placed Electrical Intestinal Pacemaker

HSP90-DIRECTED VISUALIZATION AND THERAPY OF INFLAMMATION AND INFECTION

METHOD AND SYSTEM FOR FILTERING IMAGE DATA AND USE THEREOF IN VIRTUAL ENDOSCOPY

NON-INVASIVE IDENTIFICATION OF INTESTINAL ISCHEMIA FROM MEASUREMENT OF BASIC ELECTRICAL RHYTHM OF INTESTINAL SMOOTH MUSCLE ELECTRICAL ACTIVITY

Intestinal ischemia is diagnosed non-invasively by scanning the abdomen (7) externally with a SQUID magnetometer (9) which measures the magnetic field (5) produced by smooth muscle electrical activity. These measurements are processed to determine the basic electrical rhythm (BER) frequency at various locations (43) along the intestine (1). A nominal value for the BER frequency is established at each location (43), and if the measured value falls below the associated nominal value by more than a predetermined margin, ischemia at that location is indicated. Ischemia is further indicated by an internal of arrhythmia in which the BER frequency increases to a range of about 24-180 cpm or at least about twice the nominal value. The BER frequency values are presented on a graphic display (39) which provides an indication of the nominal value at an affected location (43) from the gradient of the measured values at adjacent normal locations. Also, a gradual reduction in the local BER frequency ...

Immunoassay Method For The Diagnosis Of Gastric Intestinal Metaplasia Associated With Gastric Carcinoma

This invention pertains to an in vitro immunoassay method for diagnosing human gastric intestinal metaplasia which comprises the steps of (a) contacting a gastric tissue sample of a subject suspected of having human gastric intestinal metaplasia cells with the monoclonal antibody DAS-1, or a fragment thereof, which monoclonal antibody is produced by the hybridoma deposited under ATCC accession number HB 9397 and which reacts with human gastric intestinal metaplasia antigen; and (b) detecting immunoreactivity between the gastric tissue and the monoclonal antibody, such immunoreactivity indicating a positive diagnosis of human gastric intestinal metaplasia. This invention also pertains to an in vivo immunoassay method for diagnosing human gastric intestinal metaplasia which comprises the steps of (a) administering to a human, suspected of having human gastric intestinal metaplasia, the monoclonal antibody DAS-1, or a fragment thereof, which monoclonal antibody is produced by the hybridoma ...

System and method for modeling a tracking curve of an in vivo device

A system and method to model a tracking curve of an in-vivo device capturing in-vivo data of the colon is provided. Data analysis is performed on a raw tracking curve to identify one or more milestone data points that correspond to defined locations in the colon. A modeled path may be defined between and along the selected milestone data points. Raw tracking curve data may be translated to modeled data along the modeled path. The modeled tracking curve may be displayed alongside a streaming display of captured in-vivo image frames of the colon.

MOTILITY MANOMETER PRIMING MANIFOLD SYSTEM WITH ICON-BASED USER INTERFACE AND WIRELESS CONNECTIVITY

A catheter includes a distal distension balloon and circumferentially arranged motility measurement balloons proximal of the distension balloon. A manifold includes balloon ports each configured to fluidly couple to a motility measurement balloon, pressure transducer ports, and a priming port. A port selector is coupled to the manifold and movable between different positions. Each port selector position causes the manifold to establish different fluidic couplings between the respective motility balloon, pressure transducer, and priming ports. A pressure sensing device includes pressure transducers each fluidly coupled to one of the pressure transducer ports. The pressure sensing device is configured to coordinate calibration of the pressure transducers at atmospheric pressure with the port selector in a first position and motility balloon pressure measurements with the port selector in a third position. Priming of the motility measurement balloons is implemented by moving the port selector to a second position. 116-. (canceled)17. A method of operating a manometry catheter , comprising:selectively establishing different fluidic couplings between a distal distension balloon and a plurality of circumferentially arranged motility measurement balloons of the manometry catheter, a plurality of pressure transducers, and a priming port of a rotatable manifold in accordance with different orientations of the manifold fluidly coupled thereto, the manifold comprising a priming port and a rotatable elongated cylinder comprising an arrangement of bores provided therein;calibrating, with the manifold in a first rotational position, the pressure transducers at an atmospheric pressure;charging, with the manifold in a second rotational position, the motility measurement balloons so as to inflate the motility measurement balloons;after charging the motility measurement balloons, exposing the motility measurement balloons to the atmospheric pressure; andoperating, with the manifold ...

Incontinence Detection System Capable of Identifying Urinary or Fecal Incontinence

An incontinence detection system includes an incontinence detection pad underneath a patient's pelvic area for detecting an incontinence event. The incontinence detection system further includes a moisture detection sensor, a gas detection sensor, and a reader. The moisture detection sensor is embedded in the incontinence detection pad for detecting a presence of moisture in incontinence detection pad. The gas detection sensor is positioned near the incontinence detection pad for detecting a presence of targeted gas, such as methane. The reader is communicatively coupled to the moisture detection sensor and the gas detection sensor to receive moisture data and gas data, respectively. The reader is configured to determine a type of the incontinence event based on the received moisture data and the gas data and transmit a signal indicative of the type of incontinence event to a server.

POLYP TRAP

A polyp trap has an upper housing with a domed, top view window for viewing tissue retained by a disk seated in a lower housing which is held in place by the upper housing, when the upper housing is coupled to the lower housing. In one example, the upper housing holds the disk in place by engaging a post, which doubles as a handle for removing tissue from the trap with the disk and transferring the tissue to a storage container or bag. Mating posts in the lower housing may engage guide holes in the disk to further secure the disk in the trap.

SYSTEMS, DEVICES AND METHODS FOR ASSESSMENT OF BODY CAVITY PRESSURES

Systems, devices and methods that can be used to obtain objective pressure measurements in a body cavity using one or more monitoring bladders mounted on a catheter. The monitoring bladders may be adapted to connect or be connected to a system capable of providing objective pressure measurements indicative of the compressive forces acting on the one or more monitoring bladder in the body cavity. The body cavity may include, for example, the rectum, esophagus, stomach, intestine, colon, reproductive tract, urethra, oronasopharnygeal tract, etc. 131-. (canceled)32. A body cavity pressure measuring device that comprises:a catheter comprising a proximal end and a distal end;a distention device mounted on the catheter proximate the distal end of the catheter, wherein the distention device is expandable and collapsible between a collapsed configuration and a distended configuration;a plurality of monitoring bladders mounted on the catheter at a location proximal to the distention device, wherein the plurality of monitoring bladders are positioned about a periphery of the catheter at the same longitudinal position, wherein each monitoring bladder occupies only a portion of the periphery of the catheter;a plurality of monitoring lumens, wherein each monitoring lumen of the plurality of monitoring lumens extends proximally through at least a portion of the catheter from the monitoring bladder towards the proximal end of the catheter, wherein each monitoring lumen is in fluid communication with an interior of one monitoring bladder such that a fluid pressure in the one monitoring bladder is communicated through the monitoring lumen;wherein the distention device comprises a maximum transverse dimension in the distended configuration that is larger than any maximum transverse dimension of the pressure measuring device in the length occupied by the plurality of monitoring bladders, wherein the maximum transverse dimensions are measured transverse to the longitudinal axis.33. A ...

EXTERNALLY MOVEABLE INTRACAVITY PROBE FOR MRI IMAGING AND SPECTROSCOPY

ПРИЕМНИК КАЛОВЫХ МАСС ЧЕЛОВЕКА

Настоящее изобретение относится к медицинской технике, а именно к приемнику каловых масс человека, состоящему из крепежной пластины, содержащей левую С-образную пластину и правую С-образную пластину, концы которых соединены друг с другом с образованием сквозной центральной части и с возможностью складывания друг на друга; приемного мешка каловых масс, конец которого прикреплен к одной боковой стороне крепежной пластины, и который обычным образом скручен с целью вставки между сложенными левой С-образной пластиной и правой С-образной пластиной крепежной пластины, и который выталкивается из сквозного отверстия крепежной пластины при поступлении каловых масс; и клеевого элемента. Поскольку приемный мешок каловых масс не соприкасается с задним проходом при носке, дефекация облегчается за счет повышенного комфорта. 20 з.п. ф-лы, 12 ил.

СПОСОБ ПРОФИЛАКТИКИ РАЗВИТИЯ ВЫРАЖЕННОГО СИНДРОМА НИЗКОЙ ПЕРЕДНЕЙ РЕЗЕКЦИИ

Изобретение относится к медицине, а именно к онкологии. Пациенту до начала химиолучевой терапии проводят аноректальную манометрию высокого разрешения. Осуществляют предоперационный курс химиолучевой терапии, через 8 недель после его завершения повторно проводят аноректальную манометрию высокого разрешения с последующим выполнением оперативного вмешательства в объёме низкой передней резекции прямой кишки с выведением превентивной илеостомы. При снижении уровня максимального давления сжатия на 30% от исходного значения и более и повышении объёма первого ощущения на 60% и более по данным аноректальной манометрии высокого разрешения через 8 недель после завершения химиолучевой терапии выполняют закрытие илеостомы в срок до 2 месяцев после низкой передней резекции прямой кишки с превентивной илеостомой. Способ позволяет уменьшить частоту развития выраженного синдрома низкой передней резекции (СНПР) у пациентов за счет закрытия илеостомы в срок до 2 месяцев после низкой передней резекции с превентивной ...

СПОСОБЫ ОЦЕНКИ СОСТОЯНИЙ ЗДОРОВЬЯ С ПРИМЕНЕНИЕМ ВИЗУАЛИЗАЦИИ МЕТОДОМ МАГНИТОИНДУКЦИОННОЙ ТОМОГРАФИИ С ПОМОЩЬЮ ОДНОЙ КАТУШКИ

VORRICHTUNG ZUR FERNMESSUNG MITTELS EINES TONOMETRIE-KATHETERS

VON AUSSEN BEWEGBARE KÖRPERSONDE ZUR MRI-BILDERZEUGUNG UND ZUR SPEKTROSKOPIE

Colon representing method for patient, involves producing processed data by segmenting and removing image information of colon contents marked with contrast medium during recording of image data detected by colon folds

The method involves producing computer tomographic image data i.e. primary image data, of a patient (7) within an area of colons under presence of X-ray contrast medium in colon contents. Colon folds are detected in the image data. A set of processed data is produced by segmenting and removing image information of intestine contents marked with the contrast medium during recording of the image data detected by the intestine folds. A set of processed image data is represented. An independent claim is also included for an image processing device connected with a computer tomography system.

Unit for measuring ring muscle contraction forces

Contraction force of ring muscles at body orifices, partic. at the large intestine, is measured by a probe (12) with an electric pressure transducer (13) at the end of a tube (9) connectable to the probe. The probe consists of rotationally symmetrical web (1) with threads (5,5') at either end for attachment of a head piece (2) and an end piece (3). The web is thickened (4,4') at its ends and a thin-walled, elastic tube (6) is fitted over the thickened portions, the end of which are hermetically sealed by the head piece and end piece. The max. dia. of the web in its central region is 6 mm. It may be mfd. from metal or plastic.

TONOMETRISCHE KATHETER-KOMBINATION

TONOMETRISCHE KATHETERVORRICHTUNG UND VERFAHREN MIT FERNSENSOR

Vibrating capsule for gastrointestinal treatment, and method of use thereof

Apparatus and method for measurement of bowel wall inflammation or permeability

Measuring the inflammation or permeability of the bowel wall comprises obtaining nuclear magnetic resonance measurements, in the form of an image 4, of at least a bowel including the bowel wall. A portion of the bowel wall is isolated within the image and a nuclear magnetic resonance measurement is determined for the isolated bowel wall. A measurement of the inflammation or permeability of the isolated bowel wall is then calculated based on its nuclear magnetic resonance measurement. The measurements may be used to investigate inflammatory bowel disease, Crohn’s disease, diverticulitis, etc. The NMR measurements may comprise T2 measurements of the tissue. Corrections 8 for movement may be made by obtaining a plurality of temporally spaced images. The calculated measurement of the inflammation or permeability may be an indirect measurement, based on a correlation between the NMR measurement and the inflammation or permeability of the bowel wall. The measurement may be calculated on a numerical ...

System for monitoring anastomoses

High-throughput production of ingestible event markers

High-throughput ingestible event marker manufacturing systems are provided. The systems include an assembly unit configured to stably associate an ingestible event marker with a carrier to produce a product. Also provided are manufacturing methods to produce such products which include assembling an ingestible event marker with an assembly unit configured to stably associate an ingestible event marker with a carrier.

Orifice probe apparatus and a method of use thereof

An orifice probe, particularly for detecting if a patient has or has a risk of having cauda equina syndrome and a method for using same, the probe having a body for insertion into the anus of a patient, a sensing device for measuring at least one of the rectal tone and perianal or rectal sensation, and an output device for yielding at least one of the measurement of the rectal tone of the patient and whether the patient has perianal or rectal sensation.

System for continuous measuring, recording and monitoring of the splanchnic tissue perfusion and the pulmonary physiological dead space, and use thereof

The present invention relates to a new system for measuring, recording and monitoring the splanchnic tissue perfusion and the pulmonary physiological dead space in an automated way, both continuously and intermittently, and in real time, which is easy to manage and generates information easy to interpret. Said system comprises at least four measuring devices of medical parameters, connected to a device receiving, converting, storing, integrating, processing, and allowing the management and display of the data recorded in the measurements and the parameters estimated by the same. For this purpose, said device comprises a specific computer program of estimation of parameters related to the measurement of the splanchnic tissue perfusion and the pulmonary physiological dead space, from the data derived from the measuring devices. Likewise, the present invention is related to the use of a device for measuring, recording and monitoring of the splanchnic tissue perfusion and the pulmonary physiological dead space.

Detector and Method for Detection of H. Pylori

An inexpensive, portable, hand held, point-of-care, non-invasive breath-analyzer for the detection of H. Pylori in adults and children by measuring ammonia in breath using a polyaniline-carbon nanotube sensor.

METHODS AND DEVICES FOR DETECTING BOWEL PERFORATION

The present disclosure relates to methods and devices to detect perforation of the bowel, for example, resulting from surgical procedures, such as laparoscopy, diagnostic procedures, such as colonoscopy, medical conditions, such as diverticulitis, and trauma. The present disclosure also relates to filtration systems and electrical connector assemblies for use in the methods and devices. 1. A bowel perforation detection device comprising:a sample delivery unit comprising an aspirate filtering means;a sensing unit comprising a gas-detecting means, a pump, a processor, and a display; anda connecting means connecting the sample delivery unit and the sensing unit.2. The device of wherein said aspirate filtering means comprises a first filter and a second filter.3. The device of wherein said first filter is a hydrophobic porous membrane filter having pore sizes ranging from about 100 microns to about 500 microns.4. The device of wherein said second filter is a hydrophobic filter having minimum pore size of 0.2 microns or a hydrophilic filter having a minimum pore size of 0.01 microns.5. The device of wherein said aspirate filtering means comprises:an outer housing section;an inner tubing section, a portion of which is perforated;a sleeve comprising an absorbent wicking material disposed between the perforated tubing and the outer housing;a hydrophobic liquid filter having pore sizes ranging from about 100 microns to about 500 microns; anda gas/microbial filter.6. The device of wherein said sample delivery unit further comprises a one-way valve in the tubing.7. The device of wherein said gas-detecting means is selected from the group consisting of contact gas sensors claim 1 , non-contact gas sensors claim 1 , and combinations thereof.8. The device of wherein said gas-detecting means is selected from the group consisting of a carbon dioxide gas sensor claim 1 , a methane gas sensor claim 1 , a hydrogen gas sensor claim 1 , a sulfide gas sensor claim 1 , a nitrogen gas ...

SURGICAL TISSUE MONITORING SYSTEM

A tissue monitoring system includes an introducer having an inflatable section and a plurality of electrodes disposed thereon. The electrodes are alternatively connected to an electrode contact system which includes at least one signal line and at least one measurement line for taking readings about a circumferential segment of tissue encompassed by the electrodes. 1. A method of monitoring tissue comprising:placing an introducer having an inflatable section and a plurality of electrodes disposed about the inflatable section adjacent to a section of tissue;distending the first inflatable section of the introducer;imposing an electrical signal on the tissue using a subset of the plurality of electrodes selected for an electrode contact system;measuring a resulting potential with the subset of the plurality of electrodes of the electrode contact system; andshifting the electrode contact system to alternate placement of the electrode contact system within the tissue.2. The method of claim 1 , wherein the step of shifting the electrode contact system includes electronically shifting each contact of the electrode contact system to encompass a different subset of the plurality of electrodes.3. The method of claim 2 , wherein electronically shifting each contact includes shifting each contact to an adjacent electrode on the inflatable section of the introducer.4. The method of claim 1 , wherein the introducer further includes a shaft extending through the introducer claim 1 , and wherein the step of shifting the electrode contact system includes rotating the shaft to shift the electrode contact system clockwise or counterclockwise around a circumferential segment of the tissue.5. The method of claim 1 , further comprising repeating the step of shifting the electrode contact system until an entire circumference of the tissue is characterized.6. The method of claim 1 , wherein the step of imposing an electrical signal includes attaching two electrodes of the subset of the ...

Estimation of distances and size of lesions in the colon with an imaging capsule

A method of estimating distances in a colon of a subject, including: orally administering to a subject a contrast agent, orally administering an imaging capsule to the subject, emitting radiation from the imaging capsule at a location in the colon, detecting photons that are returned from an interaction of the radiation with an inner wall of the colon and contents of the colon, summating the detected photons with energies corresponding to X-ray florescence interactions to form a first count, summating the detected photons with energies corresponding to Compton back-scattering interactions to form a second count, determining the distance from the imaging capsule to the inner wall of the colon and a concentration of the contrast agent at the location of the imaging capsule in the colon using the values of the first count and the second count.

METHODS AND COMPOSITIONS FOR NON-INVASIVE, DYNAMIC IMAGING OF INTESTINAL MOTILITY

Described are methods and composition for use in non-invasive imaging of intestinal structure and function. These methods can be used to identify, diagnose, assess, monitor and direct therapies for gastrointestinal diseases and disorders. Embodiments of the methods utilize highly sensitive optical imaging and fluorescent spectroscopy techniques to track or monitor packets of organic dye excreted in bile into the intestinal tract to provide quantitative information regarding intestinal propulsion and function. 1. A method of non-invasively imaging gastrointestinal motility in a subject having an abdominal surface and a gastrointestinal tract , the method comprising:a) selecting a subject that has been administered an animal foodstuff comprising at least one auto fluorescent compound;b) illuminating the abdominal surface with an excitation light to excite the auto fluorescent compound;c) continuously, non-invasively detecting fluorescent emissions from the auto fluorescent compound to image at least a region of the gastrointestinal tract of the subject;d) capturing a plurality of images of said one or more regions of the gastrointestinal tract of the subject, based on said detected auto fluorescent emissions; ande) tracking in vivo propulsion of said auto fluorescent compound through the one or more regions of the gastrointestinal tract, based on said captured images.2. The method of claim 1 , wherein (a) selecting a subject comprises:i) administering an animal foodstuff comprising at least one auto fluorescent compound to the subject; andii) allowing sufficient time for said foodstuff to enter into the gastrointestinal tract of the subject;3. The method of claim 1 , wherein the auto fluorescent compound has an excitation wavelength ranging from about 700 nm to about 900 nm.4. The method of claim 1 , wherein (c) comprises using an intensified charge-coupled camera.5. The method of claim 1 , wherein (b) comprises illuminating the tissue surface with an excitation light ...

METHODS FOR DIAGNOSIS OF COLORECTAL CANCER

Methods and systems for use of phenotypic markers, principally oral mucosal vascular density alone or in combination with detection of other markers, to identify individuals afflicted with or having an increased risk of hereditary colorectal cancer, especially familial adenomatous polyposis, are disclosed. 1. A method for diagnosing familial adenomatous polyposis (FAP) or an increased risk of FAP in a test subject believed to be at risk for such cancer , the method comprising:(a) positioning a sampling area of the oral mucosa of the test subject in a system for measuring the oral mucosal vascular density (OMVD);(b) transilluminating the sampling area of the oral mucosa of the test subject with a light source from the system in a range of wavelengths from 470 nm to 700 nm for a period of time;(c) obtaining at least one or more images of the illuminated sampling area of the test subject using a camera from the system;(d) storing the at least one or more images of (c) on an electronic storage device on a computer;(e) analyzing the at least one or more images of the test subject stored on the electronic storage device to provide an oral mucosal vascular density (OMVD) value from a selected portion of the one or more images; and(f) comparing the OMVD values of the at least one or more images of the test subject to one or more OMVD values of one or more control subjects which are not afflicted with colorectal cancer; and(g) diagnosing the test subject has having adenomatous polyposis (FAP) or an increased risk of FAP when there is found a statistically significant increase in OVMD value in the test subject when compared to the one or more control subjects.26.-. (canceled)7. The method of claim 1 , further comprising analysis of oral mucosal reflectance (OMR) in the one or more subjects compared to controls.8. (canceled)9. The method of claim 7 , wherein the difference between the OMR measurements in the one or more subjects does not differ from the OMR measurements in the ...

SINGLE SCAN MULTI-PROCEDURE IMAGING

A method includes receiving a signal indicative of a single user selected imaging protocol for scanning a patient. The imaging protocol includes parameters for two or more of a bone mineral density, a fat composition, or an aortic calcium imaging procedures. The method further includes performing a single scan of the patient using the single user selected protocol. The method further includes generating a single set of image data for the two or more of a bone mineral density, a fat composition, or an aortic calcium imaging procedures. 1. A method , comprising:receiving a signal indicative of a single user selected imaging protocol for scanning a patient,wherein the imaging protocol includes parameters for two or more of a bone mineral density, a fat composition, or an aortic calcium imaging procedures;performing a single scan of the patient using the single user selected protocol; andgenerating a single set of image data for the two or more of the bone mineral density, the fat composition, or the aortic calcium imaging procedures.2. The method of claim 1 , further comprising:receiving a signal indicative of one or more user selected analysis algorithms, wherein the one or more user selected analysis algorithms include at least two of a bone mineral density algorithm, a fat composition algorithm, or an aortic calcium algorithm; andprocessing the single set of image data using the one or more user selected analysis algorithms, producing a processing result.3. The method of claim 2 , wherein the processing result includes at least one of a bone mineral density image claim 2 , a fat composition algorithm image claim 2 , or an aortic calcium image.4. The method of claim 3 , further comprising:concurrently displaying the at least one of the bone mineral density image, the fat composition algorithm image, or the aortic calcium image in a same view port of a graphical user interface.5. The method of claim 3 , further comprising:concurrently displaying the at least one of ...

SYSTEM FOR MARKING A LOCATION FOR TREATMENT WITHIN THE GASTROINTESTINAL TRACT

A device and method for mapping, diagnosing and treating the intestinal tract is provided using a capsule passing through the intestinal tract. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of sensed information may be derived from the pass of a capsule. Capsules may be subsequently passed through to treat the intestinal tract at a determined location along its length. One variation uses an electrical stimulation capsule to treat and/or diagnose a condition in the intestinal tract. 1. A system for the delivery of a drug to a gastrointestinal tract , the system comprising:a capsule sized to pass through an intestinal tract of a patient;a transmitter coupled to the capsule, the transmitter configured to transmit a tracking signal between the capsule and a location external to a patient's body to track a linear position of the capsule within the patient's intestinal tract as the capsule is passing through the intestinal tract;a reference signal generator coupled to the capsule, the reference signal generator configured to generate and transmit a reference signal for identifying a time of tracking signal origination;a drug delivery device configured to deliver drug to the intestinal tract; anda controller configured to actuate the drug delivery device as the capsule is passing through the intestinal tract at a desired position in the intestinal tract based on the capsule position within the intestinal tract.2. The system of wherein the drug delivery device comprises a pump.3. The system of claim 1 , wherein the drug delivery device comprises a valve or a solenoid.4. The system of claim 1 , wherein the controller is actuable responsive to an external signal.5. The system of claim 4 , wherein the drug delivery device includes an RF receiver for ...

Estimation device, program, estimation method, and estimation system

Includes an extraction unit that extracts first information on a physiological state of a subject and second information on at least one of an emotion and organ activity of the subject from information on a physiology of the subject; a calculation unit that obtains a degree of similarity between changes over time indicated by the first information and the second information which are extracted and calculates a shift amount from a predetermined state in which a homeostasis in the subject is maintained based on the obtained degree of similarity; and an estimation unit that estimates a pathology of the subject based on the calculated shift amount.

SWALLOWABLE CAPSULE, SYSTEM AND METHOD FOR MEASURING GASTRIC EMPTYING PARAMETERS

Embodiments provide devices, systems and methods for measuring a gastric emptying (GE) parameter (GEP). Many embodiments provide a swallowable capsule having three electrodes one covered by a coating which remains in the stomach but is degraded in the small intestine (SI). The electrodes are coupled to circuitry such that when the capsule is in the stomach, current flow occurs between the first two electrodes generating a first signal and in the SI current flow occurs between the second and now uncovered third electrode generating a second signal. These two signals can be transmitted and analyzed externally or by an internal controller to determine a GEP e.g., GE time. The patient may wear an external device configured to receive and analyze the signals to determine GE time. Embodiments of the invention may be used to diagnose gastroparesis and provide patient's information on when to eat meals or administer insulin after eating. 1. (canceled)2. A swallowable capsule for measurement of a gastric emptying parameter in a gastro-intestinal (GI) tract of a patient , the capsule comprising:a first, second, and third electrode;a first circuit electrically coupled to the first and second electrodes, the first circuit configured to generate a first input signal based on a current flow between the first and second electrodes at a first location in the GI tract;a second circuit electrically coupled to the second and third electrodes, the second circuit configured to generate a second input signal based on a current flow between the second and third electrodes at a second location in the GI tract different from the first location; anda controller operatively coupled to the first and second circuits, wherein the controller is programmed to determine the gastric emptying parameter based on information relating to the first and second input signals.3. The capsule of claim 2 , wherein the first location is the stomach and the second location is the small intestine.4. The capsule ...

CAPSULE AND METHOD FOR TREATING OR DIAGNOSING CONDITIONS OR DISEASES OF THE INTESTINAL TRACT

A device and method for mapping, diagnosing and treating inflammatory disorders (such as Crohn's disease) or other diseases, disorders or conditions of the intestinal tract is provided using a capsule passing through the intestinal tract. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of sensed impedance and or temperature may be derived from the pass of a capsule to diagnose the disorder or disease. The capsule or subsequently passed capsules may treat, further diagnose, or mark the intestinal tract at a determined location along its length. 1providing an autonomous capsule comprising an impedance sensor;sensing with the impedance sensor, an impedance of a portion of a gastrointestinal tract at a first impedance location along a length of the gastrointestinal tract;sensing with the impedance sensor, an impedance of a portion of a gastrointestinal tract at a second impedance location along a length of the gastrointestinal tract; anddetermining whether the impedance at the first impedance location is different from the impedance at the second impedance location by a predetermined difference.. A method for diagnosing an inflammatory gastrointestinal disorder comprising: This application is a continuation of U.S. application Ser. No. 13/215,182 filed Aug. 22, 2011, which is a divisional of U.S. application Ser. No. 10/744,558 filed Dec. 22, 2003 and issued as U.S. Pat. No. 8,005,536 on Aug. 23, 2011 which claims the benefit of Provisional Application Ser. No. 60/436,154, filed on Dec. 24, 2011, said U.S. application Ser. No. 10/744,558 is also a continuation-in-part of U.S. application Ser. No. 09/892,404 filed Jun. 26, 2001 and issued as U.S. Pat. No. 7,160,258 on Jan. 9, 2007; all of the aforementioned priority applications are hereby ...

DEVICES, SYSTEMS, AND METHODS FOR DETERMINING INFLAMMATION AND/OR FIBROSIS

A method for evaluating a gastrointestinal tract of a subject may comprise using a sensor located in the subject to obtain data regarding qualities of a tissue of the gastrointestinal tract; using the obtained data, determining a measure of perfusion of blood in the tissue; using the obtained data, determining a measure of thickness of the tissue; using the measure of perfusion and the measure of thickness, determining a measure of inflammation of the tissue; and using one or more of the measure of perfusion, the measure of thickness, and the measure of inflammation, classifying a state of the tissue. 1. A method for evaluating a gastrointestinal tract of a subject , the method comprising:using a sensor located in the subject to obtain data regarding qualities of a tissue of the gastrointestinal tract;using the obtained data, determining a measure of perfusion of blood in the tissue;using the obtained data, determining a measure of thickness of the tissue;using the measure of perfusion and the measure of thickness, determining a measure of inflammation of the tissue; andusing one or more of the measure of perfusion, the measure of thickness, and the measure of inflammation, classifying a state of the tissue.2. The method of claim 1 , wherein classifying a state of the tissue includes classifying a fibrotic attribute of the tissue.3. The method of claim 1 , wherein the sensor is an optical sensor located in a lumen of the gastrointestinal tract.4. The method of claim 3 , wherein the measure of perfusion is a perfusion index claim 3 , wherein the perfusion index is a ratio of an amount of pulsatile light received by the sensor to an amount of total light received by the sensor.5. The method of claim 1 , wherein determining a measure of inflammation comprises:applying a first function to the measure of perfusion; andapplying a second function to the measure of thickness.6. The method of claim 5 , wherein determining a measure of inflammation further comprises adding ...

Peristaltic sound detection apparatus, method for detecting peristaltic sound, and recording medium

A peristaltic sound detection apparatus ( 10 ) includes matching coefficient calculation means for calculating a plurality of matching coefficients by individually matching a frequency spectrum of a biological sound and a plurality of standard frequency spectra of peristaltic sounds.

METHODS AND SYSTEMS FOR TREATING GASTROINTESTINAL AND INFLAMMATORY HEALTH CONDITIONS USING PRESCRIPTION DIGITAL THERAPEUTICS

A prescription digital therapeutic (PDT) system is provided to patients/users suffering from gastrointestinal (GI) and/or inflammatory health conditions, wherein the PDT system allows guided behavioral therapy and skills training to be administered in a convenient and flexible, yet structured fashion, via a system associated with an application such as a mobile application. Guided behavioral therapy technologies may be based at least in part on cognitive behavioral therapy (CBT) techniques to allow for development of a skillset for treating gastrointestinal (GI) and/or inflammatory diseases, disorders and/or conditions, and for managing stress and/or other psychological symptoms associated with such diseases, disorders and/or conditions. Patient interactions with the PDT system are monitored to control progression through the system content and to continually refine one or more personalized intervention regimens associated with the guided behavioral therapy. 1. A computing system implemented method comprising:providing a patient with a user interface to a therapeutics system;performing, by the therapeutics system, a pre-assessment of a patient exhibiting one or more health condition symptoms;generating, by the therapeutics system, patient profile and pre-assessment data based on the results of the patient pre-assessment;processing, by the therapeutics system, the patient profile and pre-assessment data to generate patient condition data;processing, by the therapeutics system, the patient profile and pre-assessment data and the patient condition data to generate a personalized intervention regimen for the patient wherein the personalized intervention regimen for the patient defines one or more interactive therapy modules to be administered to the patient;administering the one or more interactive therapy modules to the patient through the user interface of the therapeutics system according to the personalized intervention regimen generated for the patient;monitoring ...

HYDROGEN BREATH ANALYZER AND BREATH TEST METHOD

The present invention provides an improved breath analyzer and breath test method to determine the presence of a gastrointestinal disorder in a human subject's digestive tract. 1. A handheld , portable breath analyzer , comprising:a main body; anda removable mouthpiece, wherein the removable mouthpiece removably attaches to the main body;wherein the main body includes a sensor, a processor, a power source and an electrical circuit;wherein the electrical circuit operably connects the power source to the sensor and connects the sensor to the processor;wherein the sensor comprises a conductive material and a hydrogen selective material in contact with the conductive material, wherein the hydrogen selective material has a resistivity that increases in response to increased concentration of hydrogen, wherein humidity immediately surrounding the sensor is controlled within a predetermined range of humidity and the hydrogen selective material has a resistivity that increases in response to the predetermined range of humidity, wherein the predetermined range of humidity is from 0.1% to 15%, wherein the hydrogen selective material comprises polyaniline, wherein the polyaniline is doped with a dopant that increases pH sensitivity of the polyaniline, wherein the dopant comprises dinonylnapthylsulfonic acid, and wherein the polyaniline has a resistivity that increases in response to increased concentration of hydrogen; andwherein the processor detects resistivity of the sensor and uses the resistivity to calculate a concentration of hydrogen.2. The breath analyzer of wherein the polyaniline has a pH sensitivity of more than 59 mV.34.-. (canceled)5. The breath analyzer of wherein the dopant consists essentially of dinonylnapthylsulfonic acid.6. The breath analyzer of wherein the conductive material comprises a plurality of electrodes.7. The breath analyzer of wherein the plurality of electrodes comprise interdigitated finger electrodes.8. The breath analyzer of wherein the ...

ANASTOMOTIC LEAKAGE DETECTION THROUGH DUAL ACTION CATHETER

Technologies are generally described for detecting the presence of anastomotic leakage in the abdominal cavity through a dual action catheter placed in the vicinity of a surgery site. A portion of the dual action catheter may be affixed around the surgery site, for example, coiled around the surgery site on the intestine. Through openings on the catheter near the surgery site, a neutral fluid such as saline solution may be injected and extracted through the same openings resulting in retrieval of fluids in the same are. By testing the extracted fluids, chemical and biochemical activity within the abdominal cavity may be determined in order to gauge the start of any anastomotic leakage. 1. A method for detecting presence of anastomotic leakage inside a body , the method comprising:positioning a dual action catheter in a vicinity of a surgery site;causing a neutral fluid to be injected into abdominal cavity near the surgery site through openings on the dual action catheter;causing abdominal cavity fluids near the openings on the dual action catheter to be extracted, wherein the neutral fluid is injected and the abdominal cavity fluids are extracted simultaneously by employing a dual action syringe coupled to the dual action catheter; andtesting the extracted abdominal cavity fluids for presence of one or more substances indicating the anastomotic leakage.214.-. (canceled)15. The method of claim 1 , further comprising:affixing the catheter near the vicinity of the surgery site through sutures or a staple system during surgery.16. The method of claim 15 , wherein the catheter comprises a memory polymer and affixing the catheter near the vicinity of the surgery site comprises forming one or more loops around the surgery site.17. The method of claim 16 , further comprising:upon completion of leakage monitoring, removing the catheter through a gentle rip-cord action.1822.-. (canceled)23. The method of claim 1 , further comprising:performing a calibration to determine a ...

Methods of treating medical conditions with oxygen

By manipulating the partial pressures of oxygen and nitrogen in the trapped air in the bowel with 100% non-rebreather mask oxygen, along with supportive therapy, a method will successfully decompress the colon. This is a low morbidity and low cost treatment which can be a useful adjunct in treating ileus and other gastrointestinal diseases in which luminal distension plays a role.

TREATMENT OF IRRITABLE BOWEL AND INFLAMMATORY BOWEL DISEASE

The present invention provides compositions and methods of delivery of the compositions, as well as diagnostic method steps that greatly alleviate symptoms associated with IBS and/or IBD. Diagnostic procedures determine a likelihood of one or both of IBS and IBD within a patient. The methods disclosed act to determine relevant biometrics and a cycle time for a specific digestive tract transit time in order to determine a proper dosage amount and potency and a time of administration of the compositions to facilitate delivery of active agents to targeted areas of the GI tract. 1. A method for administration of a therapeutic combination to specific situs within a GI tract of a patient , the method comprising the steps of:a. determining a GI system pass through period;b. determining a body mass of the patient;c. specifying two more situs within the GI tract of the patient for treatment with a first combination of therapeutic agents;{'b': '1', 'd. introducing a first combination of therapeutic agents comprising CBD and terpenes into the GI tract of the patient at a first time (T), said first combination of therapeutic agents included in a capsule with a delayed release mechanism, said delayed release mechanism correlated to one or both of the two more situs within the GI tract of the patient specified for treatment; and'}{'b': 2', '2, 'e. introducing a second combination of therapeutic agents comprising CBD and terpenes into the GI tract of the patient at a second time (T), wherein T is based at least in part upon one of: the GI system pass through period and the body mass of the patient.'}2. The method of wherein the first combination of therapeutic agents comprising CBD and terpenes and the second combination of therapeutic agents comprising CBD and terpenes are equivalent.32. The method of wherein T comprises four or more hours.41. The method of claim 1 , further comprising the step of: inputting into a smart device claim 1 , which smart devices comprises a processor ...

Consumption advisor computing system and method

A consumption digestion advice (CDA) tracker computing device includes a processor coupled in communication with a memory. The processor is programmed to receive user transaction data from a payment network for a selected user. In addition, the processor is programmed to retrieve food, medicine, and/or condition contraindication data from a third party database for the selected user. The processor is also programmed to process the transaction data and the food, medicine, and/or condition contraindication data to determine a personalized indicator indicating at least one contraindication relating to the transaction data. Moreover, the processor is programmed to transmit the personalized indicator to a user computing device for display.

IMAGE PROCESSING DEVICE AND METHOD OF OPERATING THE SAME

A disease-related processing section performs at least one of the calculation of an index value related to a stage of ulcerative colitis, the determination of the stage of the ulcerative colitis, or the determination of whether or not the ulcerative colitis has remitted, on the basis of the denseness of superficial blood vessels, intramucosal hemorrhage, and extramucosal hemorrhage obtained from a medical image. 1. An image processing device comprising:a processor configured to:acquire a medical image obtained from image pickup of an object to be observed; andperform at least one of calculation of an index value related to a stage of ulcerative colitis, determination of the stage of the ulcerative colitis, or determination of whether or not the ulcerative colitis has remitted, on the basis of denseness of superficial blood vessels, intramucosal hemorrhage, and extramucosal hemorrhage obtained from the medical image.2. The image processing device according to claim 1 ,wherein the processor further configured to:classify the denseness of the superficial blood vessels, the intramucosal hemorrhage, and the extramucosal hemorrhage depending on a frequency characteristic or a luminance value obtained from the medical image; anddetermine whether or not the ulcerative colitis has remitted according to the classification.3. The image processing device according to claim 1 , wherein the processor further configured to:calculate a frequency component-space distribution from the medical image;extract a first frequency characteristic region having a first frequency characteristic;extract a second frequency characteristic region having a second frequency characteristic having a frequency higher than a frequency of the first frequency characteristic;extract a third frequency characteristic region having a third frequency characteristic having a frequency higher than the frequency of the second frequency characteristic on the basis of the frequency component-space distribution; ...

Apparatus and method for use in analyzing a patient's bowel

An apparatus and method are provided for use in studying a patient's bowel which combines recording and analysis of physiologic parameters and patient sensory perception. A pain input detector, a pain transducer, and a processor are provided. A gas pressure transducer and flow meter may also be provided. Output data may be generated to reflect perceived patient pain, volume of gas delivered to the patient's bowel, and bowel pressure. An indication of perceived patient pain is processed by the processor to generate data that may used to validate a scan of a patient or may be used as a diagnostic tool.

WIRELESS BOWEL SENSOR

A sensing device can be placed within the colon to study bowel function. The sensing device can include a flexible printed circuit board that includes at least one senor configured to record data related to bowel activity from a patient's colon; and a wireless transmitter configured to send the data from the patient's colon to an external device. The sensing device can also include at least one mucosal clip configured to fix the sensor board to a wall of the patient's colon for a measurement period. The flexible printed circuit board and/or the at least one mucosal clip are configured to be passed from the patient's colon after the measurement period through normal defecation. 1. A sensing device comprising: ["at least one senor configured to record data related to bowel activity from a patient's colon; and", "a wireless transmitter configured to send the data from the patient's colon to an external device; and"], 'a flexible printed circuit board comprisingat least one mucosal clip configured to fix the sensor board to a wall of the patient's colon for a measurement period,wherein the flexible printed circuit board and/or the at least one mucosal clip are configured to be passed from the patient's colon after the measurement period through normal defecation.2. The sensing device of claim 1 , wherein the at least one sensor comprises at least one of a pressure sensor claim 1 , a conductance sensor claim 1 , and a capacitance sensor.3. The sensing device of claim 1 , wherein the at least one sensor comprises a pressure sensor claim 1 , a conductance sensor claim 1 , and a capacitance sensor claim 1 ,wherein the pressure sensor is located at a head of the printed circuit board,wherein metal mesh electrodes of the conductance sensor and/or the capacitance sensor are located at a tail of the printed circuit board.4123. The sensing device of claim 3 , wherein the metal mesh electrodes comprise three cathodes (C claim 3 , C claim 3 , and C) and one anode (A) located at ...

LEAK DETECTION

Some embodiments described herein generally relate to apparatus and methods for detecting gases in a body of a human or other animal. For example, such gases may be those normally contained within an organ of the body. The detected gases may, thus, indicate leakage of the contents of the organ into a body cavity. The apparatus may include one or more gas sensing probes at least partially positioned within a semipermeable material and configured to detect an intestinal gas and an electronic circuit coupled to the gas sensing probes. The electronic circuit may include a transmitter configured to transmit information from the gas sensing probes to an external device. 1. An implantable apparatus for detecting leakage from an internal organ into a body cavity of a subject , comprising:at least one gas sensing probe at least partially positioned within a semipermeable material and configured to detect an intestinal gas; andan electronic circuit coupled to the at least one gas sensing probe and including a transmitter configured to transmit information from the at least one gas sensing probe to an external device located outside the subject,wherein the at least one gas sensing probe and electronic circuit are configured for implantation into the subject.2. The apparatus of claim 1 , wherein the at least one gas sensing probe is configured to detect at least one of methane gas and hydrogen sulfide gas.3. The apparatus of claim 1 , wherein the at least one gas sensing probe includes at least one sensor having at least one material reactive with the intestinal gas.4. The apparatus of claim 3 , wherein the at least one sensor includes at least one of a metal oxide semiconductor device claim 3 , a conducting polymer claim 3 , a quartz crystal resonator claim 3 , and a surface acoustic wave device.5. The apparatus of claim 1 , wherein the semipermeable material includes an internal passageway and the at least one gas sensing probe is surrounded by an activated carbon material.6. ...

Device for Measuring Pressure in a Fluid

A measurement chamber, and a device for measuring pressure in a fluid, the device including a coupling element, at least one pressure transducer and at least one measuring chamber that can be filled with a fluid. The measurement chamber is mechanically coupled to the measurement surface of the pressure transducer by a membrane. The measurement chamber has at least two connection points for a fluid flow. The at least one pressure transducer is arranged in the coupling element, and the at least one measurement chamber has two outer webs opposite each other, one of the webs engaging a clamping edge of the coupling element and the other web engaging a pressing roller. The pressing roller is rotatably supported and can be connected to the coupling unit in a force-closed manner. 1. Device for measuring pressure in a fluid , comprising:a coupling element;at least one pressure transducer;at least one measurement chamber which can be filled with a fluid, wherein the measurement chamber is mechanically coupled to the measurement surface of the pressure transducer by a membrane and the measurement chamber has at least two connection points for a fluid flow; anda pressing roller with which the measurement chamber is stopped;wherein the at least one pressure transducer is arranged in the coupling element and the at least one measurement chamber has two outer webs positioned opposite each other, wherein one of the webs engages in a clamping edge of the coupling element and the other web engages in the pressing roller, wherein the pressing roller is held in a rotatable manner and can be force-fitted with the coupling unit.2. Device according to claim 1 , wherein the connection points are arranged at an angle (α) with regard to each other of 180° to 60°.3. Device according to claim 1 , wherein the connection points are arranged at an angle (β) of 0° to 60° with regard to the base area of the measurement chamber.4. Device according to claim 1 , wherein at least one of the connection ...

Bilirubin concentration measurement system

A bilirubin concentration measurement system according to the present invention includes: a sensor device attachable to a subject; and a terminal device capable of wirelessly communicating with the sensor device. The sensor device includes: a light emitting element that emits blue light; a light emitting element that emits green light; a light detection element that detects reflected light that is the blue light having been incident on skin of the subject and been reflected, and detects reflected light that is the green light having been incident on the skin of the subject and been reflected; and a communication unit that wirelessly transmits information about intensities of the reflected light detected by the light detection element. The terminal device includes: a communication unit that receives the information about the intensities of the reflected light transmitted from the sensor device; and a computing unit that calculates a bilirubin concentration using the information about the intensities of the reflected light.

SYSTEM FOR SENSING PHYSIOLOGICAL CHARACTERISTICS

The present invention provides a system for sensing physiological characteristics. The system includes a stimulating light emitting unit, a potential measuring unit, an analog-to-digital converting unit, a characteristic parameter group filtering unit, a characteristic parameter group storing unit, a comparing and calculating unit, an analysis unit, a display unit and a power supply unit. The present invention utilizes external signal light beams to stimulate the skin to fetch data of potential changes, and further observes the status of various organs or systems in the living creature by numerical means. The characteristic parameter group storing unit with the analysis unit and the display unit can remove the error probability caused by man-made operation in the prior arts, suitable for scientific research applications. 1. A system for sensing physiological characteristics , comprising:a stimulating light emitting unit, for continuously emitting signal light beams with specific wavelengths to a first region of skin of a living creature;a potential measuring unit, capable of being attached to a second region of the skin of the living creature, for measuring the electric potential of the second region;an analog-to-digital converting unit, electrically connected to the potential measuring unit, for converting the measured value of electric potential to a corresponding binary value at a sampling frequency within a measuring time;a characteristic parameter group filtering unit, connected to the analog-to-digital converting unit, for converting the binary value from the analog-to-digital converting unit into a plurality of characteristic parameter groups, wherein the plurality of characteristic parameter groups are obtained by fast Fourier transform operation and each characteristic parameter group comprises a plurality of numbers;a characteristic parameter group storing unit, for storing characteristic parameter groups and standard values for each characteristic ...

DEVICE FOR CAPTURING AND CONCENTRATING VOLATILE ORGANIC COMPOUNDS

A device for capturing and concentrating volatile organic compounds (VOCs) in a sample of breath air. The device includes an intake for accepting an air sample; a disposable mouth piece; a sensor array for measuring physical parameters of the air sample; an exhaled air sampler for capturing a pre-determined volume of air; a concentrator for concentrating VOCs in the air sample; and an ionic liquid collector, the latter of which may be removed from the device. The ionic liquid collector, which may have one compartment or multiple compartments, includes at least one ionic liquid. Analysis of VOCs in the ionic liquid or liquids may identify biomarkers that can provide a medical diagnosis for a human patient based on a sample of breath air. 1. A device comprising:(a) an intake for accepting a sample of room air;(b) a disposable mouthpiece for use by a human subject, wherein the human subject breaths in the room air through the disposable mouthpiece and exhales breath back into the disposable mouthpiece;(c) a sensor array comprising one or more sensors for measuring physical parameters in the exhaled breath;(d) an exhaled air sampler for capturing a pre-determined volume of air from the exhaled breath;(e) a concentrator for receiving the pre-determined volume of air from the exhaled air sampler and concentrating VOCs in the pre-determined volume of air; and(f) an ionic liquid collector comprising at least one ionic liquid, wherein the pre-determined volume of air comprising concentrated VOCs are deposited and/or injected from the concentrator into the ionic liquid collector.2. The device of claim 1 , further comprising a volatile organic compound (VOC) filter in communication with the intake (a) and the disposable mouthpiece (b) for cleaning the room air by removing VOCs from the room air sample.3. The device of claim 2 , further comprising a fan in communication with the intake (a) and the VOC filter for moving the room air from the intake into the VOC filter.4. The ...

Probe Deployment Device

The present disclosure relates to an apparatus for mounting on a guide member for insertion into an anatomical cavity, the apparatus comprising a body defining a cavity for receiving a guide member therethrough, a drive arrangement for moving the body along a guide member disposed through the body, a probe secured to the body for, in use, obtaining a measurement from, taking a sample of, applying a substance to, or applying a therapy to, an environment of the body, and a measurement arrangement for measuring a position relative to the guide member disposed through the body. 1. An apparatus for mounting on a guide member for insertion into an anatomical cavity , the apparatus comprising:a body defining a cavity for receiving a guide member therethrough;a drive arrangement for moving the body along a guide member disposed through the body;a probe secured to the body for, in use, obtaining a measurement from, taking a sample of, applying a substance to, or applying a therapy to, an environment of the body; anda measurement arrangement for measuring a position relative to the guide member disposed through the body.2. (canceled)3. The apparatus of claim 14 , wherein the drive arrangement comprises one or more rotating members coupled to the body and arranged to engage the guide member to move the body along the guide member.4. The apparatus of claim 3 , wherein the one or more rotating members are arranged to move the body along the guide member by frictional engagement of the guide member.5. The apparatus of claim 3 , wherein the one or more rotating members are configured as a pinion or a worm gear claim 3 , the pinion or the worm gear being arranged to move the body along the guide member by engaging a rack surface on the guide member.6. The apparatus of any one of claim 3 , wherein the drive arrangement comprises a capstan and a tendon engaging the capstan for actuating the drive arrangement.7. The apparatus of any one of claim 3 , wherein the drive arrangement ...

APPARATUS, METHOD AND COMPUTER-ACCESSIBLE MEDIUM FOR TRANSFORM ANALYSIS OF BIOMEDICAL DATA

Exemplary method, computer-readable medium and system can be provided for generating at least one information associated with at least one signal and/or data received from at least one structure. For example, it is possible to determine at least one basis based on a combination of a plurality of portions of the signal(s) and/or the data. It is also possible to generate the information(s) as a function of the basis. 1. A non-transitory computer-accessible medium having stored thereon computer-executable instructions for generating information associated with at least one of at least one signal or data received from at least one structure , wherein , when a computer arrangement executes the instructions , the computer arrangement is configured to perform procedures comprising:determining at least one basis based on a combination of a plurality of portions of at least one of the at least one signal or the data; andgenerating the information as a function of the at least one basis.2. The computer readable medium of claim 1 , wherein the combination includes at least one of a summation claim 1 , an average claim 1 , a weighted average claim 1 , or a statistical representation.3. The computer readable medium of claim 2 , wherein the summation includes a summation of a plurality of segments of the at least one signal or the data.4. The computer readable medium of claim 1 , wherein the generation of the information comprises applying a transform.5. The computer readable medium of claim 4 , wherein the transform relates a summation to at least one frequency of the at least one signal so as to generate a power spectrum.6. The computer readable medium of claim 4 , wherein the computer arrangement is further configured to quantify at least one characteristic associated with the at least one signal or the data based on the transform.7. The computer readable medium of claim 4 , wherein the computer arrangement is further configured to cause a recognition of a source pattern of ...

IN SITU IMPLANTED BIONIC ARTIFICIAL ANAL SPHINCTER SYSTEM HAVING INDEPENDENT SWING ARM STRUCTURE

An in-situ implanted bionic artificial anal sphincter system with an independent swing arm structure comprises: an energy transmission control unit and a sphincter prosthesis unit. The energy transmission control unit comprises a master control module and a percutaneous wireless energy transmission module while the sphincter prosthesis unit comprises a wireless energy receiving module, a micro power supply, a sensor, an execution unit and a slave control module. The invention has a simpler and compact structure which reduces the risk of transplanting; the middle ring with independent rotating shaft has simple structure and reduces the difficulty of installation; the hall switch is arranged in the upper ring bin to facilitate wiring; the external gear meshing transmission torque is simple and reliable. 1. An in-situ implanted bionic artificial anal sphincter system with an independent swing arm structure is characterized by comprising an energy transmission control unit and a sphincter prosthesis unit; the energy transmission control unit comprises a master control module and a percutaneous wireless energy transmission module while the sphincter prosthesis unit comprises a wireless energy receiving module , a micro power supply , a sensor , an execution unit and a slave control module , wherein: master control module that is connected with the slave control module through wireless communication transmits the control command signal to the internal slave control module , the percutaneous wireless energy transmission module is connected with the wireless energy receiving module through electromagnetic coupling , of which the internal receiving module that is connected with the micro power supply transfers the external energy to the micro power supply and charges it; the sensor and the actuator that are connected with the slave control module transmits the information on intestinal pressure , temperature and the position of the actuator , and the internal information is ...

SECOND, THIRD AND FOURTH NEAR-INFRARED SPECTRAL WINDOWS FOR DEEP OPTICAL IMAGING OF TISSUE WITH LESS SCATTERING

Light at wavelengths in the near-infrared (NIR) region in the second NIR spectral window from 1,100 nm to 1,350 nm and a new spectral window from 1,600 nm to 1,870 nm, known as the third NIR optical window, and fourth at 2200 cm−1 are disclosed. Optical attenuation from thin tissue slices of normal and malignant breast and prostate tissue, and pig brain were measured in the spectral range from 400 nm to 2,500 nm. Optical images of chicken tissue overlying three black wires were also obtained using the second and third spectral windows. Due to a reduction in scattering and minimal absorption, longer attenuation and clearer images can be seen in the second, third and fourth NIR windows compared to the conventional first NIR window. The second and third spectral windows will have uses in microscope imaging arteries, bones, breast, cells, cracks, teeth, and blood due to less scattering of light. 134. Apparatus for deep optical imaging of tissue comprises a light source with spectral distribution from 200 nm to 2500 mn; a first light filter at approximately 1 ,120 mn and a second long or high pass light filter at approximately 1 ,150 mn for a second and third windows; means for placing a tissue sample between said first and second light filters; an IR-CCD camera for receiving light after it passes through said first light filter and the tissue sample and emerges from said second light filter and having a spectral response within the approximate range of 0.9 μm-1.7 μm , whereby the second and third optical windows can be highlighted and the tissue imaged in the following windows: windows 2 at 1100 nm-1350 nm , window at 1600 nm-1800 nm and window at 2200 nm-2400 nm.2. An apparatus as defined in claim 1 , wherein windows #2 claim 1 , #3 claim 1 , and #4 have less light scattering to provide clearer images inside tissue for microscopes for linear and non linear process shown without xyz scanner.3. An apparatus as defined in claim 1 , wherein tissues to be imaged are ...

METHODS AND DEVICES FOR DETECTING BOWEL PERFORATION

The present disclosure relates to methods and devices to detect perforation of the bowel, for example, resulting from surgical procedures, such as laparoscopy, diagnostic procedures, such as colonoscopy, medical conditions, such as diverticulitis, and trauma. The present disclosure also relates to filtration systems and electrical connector assemblies for use in the methods and devices. 1. A bowel perforation detection device comprising:a sample delivery unit comprising an aspirate filtering means;a sensing unit comprising a gas-detecting means, a pump, a processor, and a display; anda connecting means connecting the sample delivery unit and the sensing unit.2. The device of wherein said aspirate filtering means comprises a first filter and a second filter.3. The device of wherein said first filter is a hydrophobic porous membrane filter having pore sizes ranging from about 100 microns to about 500 microns.4. The device of wherein said second filter is a hydrophobic filter having minimum pore size of 0.2 microns or a hydrophilic filter having a minimum pore size of 0.01 microns.5. The device of wherein said aspirate filtering means comprises:an outer housing section;an inner tubing section, a portion of which is perforated;a sleeve comprising an absorbent wicking material disposed between the perforated tubing and the outer housing;a hydrophobic liquid filter having pore sizes ranging from about 100 microns to about 500 microns; anda gas/microbial filter.6. (canceled)7. The device of wherein said gas-detecting means is selected from the group consisting of contact gas sensors claim 1 , non-contact gas sensors claim 1 , and combinations thereof.8. The device of wherein said gas-detecting means is selected from the group consisting of a carbon dioxide gas sensor claim 1 , a methane gas sensor claim 1 , a hydrogen gas sensor claim 1 , a sulfide gas sensor claim 1 , a nitrogen gas sensor claim 1 , and combinations thereof913.-. (canceled)14. A method for detecting a ...

APPARATUS AND METHOD FOR DETECTING GASTROINTESTINAL MOTOR ACTIVITY DURING POST-OPERATIVE RECOVERY

System and methods for acquiring and processing myoelectrical data from the gastrointestinal tract of a patient are provided. In various embodiments, the systems and methods monitor the motor activity of a patient recovering from surgery to detect a resumption in gastrointestinal motility. In some embodiments, the systems and methods enable proper post-operative ileus in the patient. In some embodiments, the systems and methods allow researchers or clinicians to determine the efficacy of one or more therapies intended to encourage gastrointestinal motility. In some embodiments, the systems and methods enable clinicians to predict and facilitate the proper timing of discharge from a healthcare facility following surgery. 1. A method of detecting resumption in motility within a stomach , a small intestine , and a colon of a patient following a surgical procedure , the method comprising:placing a surface electrode patch onto an abdominal region of a patient, wherein the surface electrode patch comprises a plurality of electrodes and electronic components, and wherein the surface electrode patch is positioned on the patient following a surgical procedure;acquiring, by the surface elecrode patch, an acquired signal comprising a myoelectrical activity signal;digitizing the acquired signal with an analog-to-digital converter present on the surface electrode patch;wirelessly transmitting the digitized signal to a computing device;automatically applying a time-stamp to the digitized signal; dividing a frequency spectrum of the time-stamped signal into a plurality of organ-specific spectral regions wherein a first region corresponds to the stomach, a second region corresponds to the small intestine, and a third region corresponds to the colon, and', 'summing or integrating the frequency spectrum of the time-stamped signal across each of the plurality of organ-specific spectral regions for a desired time duration, wherein a resultant value as a function of time serves as a ...

ACCURATE AND EFFICIENT POLYP DETECTION IN WIRELESS CAPSULE ENDOSCOPY IMAGES

A method for detecting polyps in endoscopy images includes pruning a plurality of two dimensional digitized images received from an endoscopy apparatus to remove images that are unlikely to depict a polyp, where a plurality of candidate images remains that are likely to depict a polyp, pruning non-polyp pixels that are unlikely to be part of a polyp depiction from the candidate images, detecting polyp candidates in the pruned candidate images, extracting features from the polyp candidates, and performing a regression on the extracted features to determine whether the polyp candidate is likely to be an actual polyp. 1. A method for detecting polyps in endoscopy images , comprising the steps of:pruning a plurality of two dimensional digitized images received from an endoscopy apparatus to remove images that are unlikely to depict a polyp, wherein a plurality of candidate images remains that are likely to depict a polyp;pruning non-polyp pixels that are unlikely to be part of a polyp depiction from the candidate images;detecting polyp candidates in the pruned candidate images;extracting features from said polyp candidates; andperforming a regression on said extracted features to determine whether said polyp candidate is likely to be an actual polyp.3. The method of claim 2 , wherein N=3 is a number of color channels claim 2 , wherein the color channels are (BUH) claim 2 , wherein B is selected from an RGB color space claim 2 , U is selected from a LUV color space claim 2 , and H is selected from a HSV color space.5. The method of claim 1 , wherein polyp candidates for an image Icomprise a plurality of ellipses {(E claim 1 , p)}for each image I claim 1 , wherein ellipse Eis a polyp region-of-interest with a polyp probability pand Nis the number of ellipses for image I.6. The method of claim 5 , wherein features extracted from said polyp candidates include geometric features and appearance based features claim 5 , wherein said geometric features include an area of each ...

SYSTEM, METHOD, AND COMPUTER ACCESSIBLE MEDIUM FOR VOLUMETRIC TEXTURE ANALYSIS FOR COMPUTER AIDED DETECTION AND DIAGNOSIS OF POLYPS

A computer-based method for diagnosing a region of interest within an anatomical structure having the steps of receiving a 3D volumetric representation of the anatomical structure, and identifying at least one volume of interest and volume of normal of the anatomical structure. A first feature set can be generated based on a density, a gradient and a curvature of the volume of interest, and the first feature set can be compared to a second feature set to diagnose the region of interest to at least one a plurality of pathology types. 1. A computer-based method for diagnosing a region of interest within an anatomical structure , comprising:receiving a 3D volumetric representation of the anatomical structure;identifying at least one volume of interest and volume of normal of the anatomical structure;determining a density, a gradient and a curvature of the volume of interest;generating a first feature set based on the density, the gradient and the curvature; andcomparing the first feature set to a second feature set to diagnose the region of interest to at least one of a plurality of pathology types.2. The computer-based method of claim 1 , wherein the generation of the first feature set comprises combining the density claim 1 , the gradient and the curvature to produce the first feature set.3. The computer-based method of claim 2 , wherein at least one of the density claim 2 , the gradient or the curvature is determined using a 3D Haralick model.4. The computer-based method of claim 3 , wherein the gradient is determined using a gray-level gradient co-occurrence matrix.5. The computer-based method of claim 3 , wherein the curvature is determined using a gray-level curvature co-occurrence matrix.6. The computer-based method of claim 3 , wherein the density is determined using a gray-level co-occurrence matrix.7. The computer-based method of claim 1 , wherein the second feature set is generated by manually analyzing a plurality of regions of interest.8. The computer- ...

IMAGING METHOD USING FLUOROQUINOLONE ANTIBIOTICS AND IMAGING DEVICE FOR THE SAME

Disclosed are an imaging method using fluoroquinolone antibiotics and an imaging device for the same, in which biological tissue is stained with Moxifloxacin as one of fluoroquinolone antibiotics, and the stained biological tissue is subjected to fluorescent image-capture through single-photon excitation with either near-ultraviolet or visible wavelength light instead of either a middle-ultraviolet light source or a femtosecond near-infrared laser device, thereby obtaining morphological information of cells in the biological tissue at a high speed without damage. To this end, an imaging method of using fluoroquinolone antibiotics includes: staining cells of the biological tissue with fluoroquinolone antibiotics; illuminating the excitation light from a light source to the biological tissue stained with the fluoroquinolone antibiotics; and capturing an image of the biological tissue through the fluoroquinolone antibiotics based fluorescence caused by the excitation light illuminated to the biological tissue, wherein the excitation light from the light source includes either near-violet or short visible wavelength light for single photon excitation of the fluoroquinolone antibiotics. 1. An imaging method of using fluoroquinolone antibiotics , the method comprising:staining cells of biological tissue with fluoroquinolone antibiotics;emitting light from a light source to the biological tissue stained with the fluoroquinolone antibiotics; andcapturing an image of the biological tissue through the fluoroquinolone antibiotics based on fluorescence excitation caused by the excitation light illuminated to the biological tissue,wherein the light from the light source comprises light for single photon excitation of the fluoroquinolone antibiotics.2. The imaging method according to claim 1 , wherein the fluoroquinolone antibiotics comprise Moxifloxacin.3. The imaging method according to claim 2 , wherein the light from the light source has a continuous wave wavelength range ...

SYSTEMS, METHODS, AND DEVICES ADDRESSING THE GASTRO-INTESTINAL TRACT

Various embodiments disclosed herein relate to an implantable device, systems, and methods related thereto, that includes at least one sensor and/or therapeutic agent delivery depot. In one embodiment, the system and device include means for detecting general or specific biological agents in a subject's intestinal tract, and utilizing the information from the detection for determining the timing and content of any therapeutic treatment needed by the subject. 1. A device , comprising:at least one reversibly inflatable bladder less than or approximately equal to 10 mm in size;at least one depot including one or more therapeutic or nutraceutical agent reservoirs;at least one activatable switch operably coupled to at least one actuator configured to deflate the reversibly inflatable bladder upon activation of the switch; andat least one sensor including one or more of a camera, ultrasound device, optical sensor, strain sensor, level sensor, or pressure sensor.2. The device of claim 1 , wherein the reversibly inflatable bladder includes the depot.3. (canceled)4. The device of claim 1 , wherein the reversibly inflatable bladder is configured claim 1 , when at least partially inflated claim 1 , to secure the device within a lumen of the gastro-intestinal tract of a subject's body.5. (canceled)6. (canceled)7. The device of claim 1 , wherein activation of the switch includes activation by at least one of a timer claim 1 , external command claim 1 , or information from the at least one sensor.8. The device of claim 1 , wherein the one or more therapeutic or nutraceutical agent reservoirs include at least one valve.9. The device of claim 8 , wherein the at least one valve is operably coupled to control circuitry and configured to dispense at least one therapeutic or nutraceutical agent from the one or more therapeutic or nutraceutical agent reservoirs.10. The device of claim 1 , wherein each therapeutic or nutraceutical agent reservoir includes a different agent than at least ...

PREDICTING RESPONSE TO THERAPY FOR ADULT AND PEDIATRIC CROHN'S DISEASE USING RADIOMIC FEATURES OF MESENTERIC FAT REGIONS ON BASELINE MAGNETIC RESONANCE ENTEROGRAPHY

Embodiments discussed herein facilitate predicting response to therapy in Crohn's disease. A first set of embodiments discussed herein relates to accessing a radiological image of a region of tissue demonstrating Crohn's disease associated with a patient; defining a mesenteric fat region by segmenting mesenteric fat represented in the radiological image; extracting a set of radiomic features from the mesenteric fat region; providing the set of radiomic features to a machine learning classifier configured to compute a probability of response to therapy in Crohn's disease based, at least in part, on the set of radiomic features; receiving, from the machine learning classifier, a probability that the region of tissue will respond to therapy; generating a classification of the patient as a responder or non-responder based, at least in part, on the probability; and displaying the classification. 1. A non-transitory computer-readable storage device storing computer-executable instructions that , when executed , cause a processor to perform operations , the operations comprising:accessing a radiological image of a region of tissue demonstrating Crohn's disease, where the radiological image includes a plurality of pixels, a pixel having an intensity, where the radiological image is associated with a patient;defining a mesenteric fat region by segmenting mesenteric fat represented in the radiological image;extracting a set of radiomic features from the mesenteric fat region;providing the set of radiomic features to a machine learning classifier configured to compute a probability of response to therapy in Crohn's disease based, at least in part, on the set of radiomic features;receiving, from the machine learning classifier, a probability that the region of tissue will respond to therapy;generating a classification of the patient as a responder or non-responder based, at least in part, on the probability; anddisplaying the classification.2. The non-transitory computer- ...

GENERATING COLONOSCOPY RECOMMENDATIONS

Computer-implemented methods of improved quantitative interpretation of cell index profiles are provided. 1. A computer-implemented method comprising:accessing, by a computer system, medical information for a patient, the medical information including, at least, a procedure note regarding a colonoscopy performed on the patient and a pathology report for the colonoscopy, the procedure note and the pathology report being in a freetext format;converting, by the computer system, the procedure note and the pathology report from the freetext format to a structured output that includes additional information and concepts that are not explicitly stated in the procedure note and the pathology report;identifying, based on i) the structured output of the procedure note and the pathology report and ii) other portions of the medical information for the patient, polyp information for the patient, personal and family medical history for the patient, and presence of hereditary medical conditions for the patient;determining, using one or more colonoscopy guideline rules, a recommendation for a follow-up colonoscopy for the patient based, at least in part, on the polyp information for the patient, the personal and family medical history for the patient, and the presence of hereditary medical conditions for the patient; andoutputting the recommendation for the follow-up colonoscopy.2. The computer-implemented method of claim 1 , wherein the other portions of the medical information for the patient include one or more of: demographic information for the patient claim 1 , coded list of medical problems for the patient claim 1 , colonoscopy findings recorded by a nurse claim 1 , and answers provided by the patient to a questionnaire.3. The computer-implemented method of claim 1 , wherein the medical information additionally includes colonoscopy indications; andwherein the colonoscopy indications are additionally converted to the structured output.4. The computer-implemented method of ...

GAS SUPPLY APPARATUS

A gas supply apparatus includes: a gas supply conduit for supplying a gas to a digestive tract; a pressure detecting device which detects a pressure in the digestive tract; a flow regulating device which regulates a gas amount supplied from the gas supply source to the digestive tract via the gas supply conduit; a first control device which controls the flow regulating device according to a result detected by the pressure detecting device to supply the gas into the digestive tract so that the pressure inside the digestive tract becomes a set pressure; a second control device which controls the flow regulating device to supply a fixed gas amount into the digestive tract; and a gas supply mode switching device which switches between gas supply modes including a mode for executing control by the first control device and a mode for executing control by the second control device. 1. A gas supply apparatus comprising:a gas supply conduit communicating with a gas supply source to supply a gas to a digestive tract inside a subject;a pressure detecting device which detects a pressure in the digestive tract;a flow regulating device which regulates an amount of the gas supplied from the gas supply source to the digestive tract via the gas supply conduit;a first control device which controls the flow regulating device according to a result detected by the pressure detecting device to supply the gas into the digestive tract so that the pressure inside the digestive tract becomes a set pressure;a second control device which controls the flow regulating device according to a capacity of the digestive tract to supply a fixed amount of the gas into the digestive tract, the fixed amount being small enough relative to the capacity of the digestive tract; anda gas supply mode switching device which switches between a plurality of gas supply modes including a first gas supply mode for executing control by the first control device and a second gas supply mode for executing control by the ...

SYSTEMS, COMPOSITIONS, AND METHODS FOR TARGETED CHALLENGE AND IDENTIFICATION OF GUT MICROBIOTA

Identifying gut microbiota in a specific site of the gut through production of a measurable response following introduction of a challenge agent to the specific site of the gut is disclosed. A composition embodiment includes, but is not limited to, a challenge agent configured to elicit a measurable response by the at least one targeted microbe at the specific site in the gut, the measurable response detectable in a bodily gaseous emission; and a controlled release system encompassing at least a portion of the challenge agent, the controlled release system configured to access the specific site of the gut. 1. A composition for detecting at least one targeted microbe in a specific site of the gut , the composition comprising:a challenge agent configured to elicit a measurable response by the at least one targeted microbe at the specific site in the gut, the measurable response detectable in a bodily gaseous emission; anda controlled release system encompassing at least a portion of the challenge agent, the controlled release system configured to access the specific site of the gut.2. The composition of claim 1 , wherein the bodily gaseous emission includes at least one of respiratory gas claim 1 , digestive gas claim 1 , breath claim 1 , or breath condensate.3. The composition of claim 1 , wherein the measurable response detectable in a bodily gaseous emission includes at least one of hydrogen claim 1 , carbon dioxide claim 1 , methane claim 1 , nitric oxide claim 1 , nitrogen claim 1 , ammonia claim 1 , a volatile organic compound claim 1 , or a taggant.47.-. (canceled)8. The composition of claim 1 , wherein the challenge agent includes at least one saccharide.9. (canceled)10. The composition of claim 1 , wherein the challenge agent includes at least one taggant claim 1 , and the measurable response detectable in a bodily gaseous emission includes at least a portion of the taggant.11. (canceled)12. (canceled)13. The composition of claim 1 , wherein the challenge ...

Measurement probe and optical measurement system

A measurement probe includes: a plurality of optical fibers including an illumination fiber configured to propagate light to irradiate a measuring object and including a light receiving fiber configured to receive scattered light retuned from the measuring object; and a detection portion configured to detect contact with the measuring object, the detection portion having a contact part provided on a part of a side portion of the measurement probe, the side portion forming a surface along a longitudinal direction of the measurement probe, the contact part being configured to be in contact with measuring object.

SYSTEMS AND METHODS FOR PREDICTING GASTROINTESTINAL IMPAIRMENT

Predicting gastrointestinal impairment may involve obtaining intestinal sounds of a patient to generate audio data, identifying predefined spectral events in the audio data that are predictive of subsequent gastrointestinal impairment, the spectral events being defined by predefined parameters, and predicting the likelihood of subsequent gastrointestinal impairment relative to the identified spectral events. 1. A system comprising:a patient interface for detecting intestinal sounds obtained before clinical signs and symptoms of a gastrointestinal impairment develop in the patient;a data collection device for processing audio data from the patient interface;a predicting device for receiving the audio data from the data collection device, identifying predefined spectral events in the audio data, the predefined spectral events being defined by predefined parameters and predictive of subsequent gastrointestinal impairment, and predicting the likelihood of subsequent gastrointestinal impairment based on the predefined spectral events.2. The system of claim 1 , wherein the predefined parameters include frequency of the predefined spectral event and the frequency is in the range of 900 to 20 claim 1 ,000 Hertz.3. The system of claim 1 , wherein the predefined parameters include duration of the predefined spectral event and the duration is in the range of 5 to 600 milliseconds.4. The system of claim 1 , wherein the predefined parameters include minimum separation in time of the predefined spectral event from other spectral events and the minimum separation in time is 20 milliseconds.5. The system of claim 1 , wherein the predefined parameters include signal-to-noise ratio of the predefined spectral event and the signal-to-noise ratio threshold is 10 decibels.6. The system of claim 1 , wherein the device predicts the likelihood of subsequent gastrointestinal impairment by counting the total number of spectral events that occurred in a predefined period of time and comparing ...

Method and apparatus for generation of combined magnetic resonance images

In a method and magnetic resonance (MR) apparatus for generating a combined MR image of an examination object, a first image data record of an examination object, generated from magnetic resonance data recorded with a first reception coil, is loaded into a computer. A second image data record of the examination object, generated from magnetic resonance data recorded with a second reception coil, wherein the first and the second reception coils are different reception coils, is also loaded into a computer. At least one interim image data record is generated by the computer by applying a mask function to the first and/or second image data record. An interim image data record is combined in the computer with the image data record to which no mask function was applied, or with the other interim image data record, to form a combined MR image.

METHODS FOR PREDICTING AND TREATING NECROTIZING ENTEROCOLITIS IN NEONATES

Embodiments are presented herein that provide early prediction of the development of necrotizing enterocolitis by a preterm infant through analysis of the high frequency component of heart rate variability, optionally with analysis of respiration rate. Methods of treatment following prediction area also reported. 1. A method for determining that a patient is at an elevated risk for developing necrotizing enterocolitis , comprising: (a) a frequency range based on a measured respiratory rate of the patient or', '(b) a frequency range reflective of a respiratory rate range for a population represented by the patient;, "monitoring a patient's heart rate to determine heart rate variability, said heart rate variability having a high frequency component that is calculated using one of"}analyzing the high frequency component of heart rate variability;determining power of the high frequency component, wherein said power is representative of parasympathetic tone; and{'sup': '2', 'when the power of the average high frequency component is less than 8 msec, determining that the patient has an elevated risk for developing necrotizing enterocolitis.'}2. The method of claim 1 , wherein said high frequency power is determined by sampling at a frequency between 800 and 1200 samples/sec.3. The method of claim 2 , wherein said high frequency power is determined by sampling at a frequency of 1000 samples/sec.4. The method of claim 1 , wherein the determination of the power of said high frequency component is validated by taking multiple 120 second epochs of data for analysis.5. The method of claim 1 , wherein the determination of the power of said high frequency component is analyzed at a spectral bandwidth of 0.3 to 1.3 Hz.6. The method of claim 1 , wherein the determination of the power of said high frequency component is performed through sampling at a frequency of 1000 samples/second claim 1 , validating by taking multiple 120 second epochs of data claim 1 , excluding clear outliers ...

DEVICE, METHOD AND PROGRAM FOR MONITORING PERFUSION OF A TISSUE

The invention includes monitoring the perfusion of a tissue of an organ using a device having a perfusion sensor to detect a perfusion of the tissue, and at least one activity sensor to detect a muscle activity of the organ. The at least one activity sensor is arranged in proximity to the perfusion sensor. Both sensors are linked to a processing unit. The processing unit receives, as input, perfusion measurement data and muscle activity data, and allows the muscle activity data to be taken into account for monitoring the perfusion of the tissue. The perfusion measurement data are invalidated during the muscle activity periods. 1. A device for monitoring the perfusion of a tissue of an organ , comprisinga perfusion sensor configured to detect a perfusion of the tissue, andat least one activity sensor configured to detect a muscle activity of the organ, said at least one activity sensor being arranged in proximity to the perfusion sensor, said sensors being configured to be linked to a processing unit.2. The device claim 1 , according to claim 1 , comprising an occlusion section comprising the activity sensor claim 1 , and a perfusion measurement section comprising the perfusion sensor.3. The device claim 2 , according to claim 2 , wherein the occlusion section is movable between a folded position in which it is small in a radial direction and a deployed position in which it is large in the radial direction.4. The device claim 3 , according to claim 3 , wherein the occlusion section comprises a balloon claim 3 , a stent or a shape-memory material claim 3 , configured to cause the occlusion section to switch between the folded position and the deployed position.5. The device claim 2 , according to claim 2 , wherein the perfusion-measurement section is inflatable and is movable between a folded position in which it is small in a radial direction and a deployed position in which it is large in the radial direction.6. The device claim 1 , according to claim 1 , wherein ...

Gastrointestinal capsule and method

The invention discloses a bidirectional ultrasonic capsule for gastrointestinal measurement. The capsule comprises pairs of ultrasonic ranging probes to obtain correlated depth or morphology data of two sides of an inner wall of a digestive tract, wherein Probe 1 is configured to range a first distance to a first side of the inner wall of the digestive tract along a first direction and Probe 2 is configured to range a second distance to a second side of the inner wall of the digestive tract along an opposite direction to the first direction, and data of the first and second distances are correlated and a sum of the first distance, the second distance and a third distance between Probe 1 and Probe 2 is obtained as a directional cavity diameter of the digestive tract, which eliminates errors caused by motion of the capsule in the digestive tract in the unidirectional measurement of the prior art. 1. A capsule , comprising one or more pairs of ultrasonic probes configured to obtain correlated data of two sides of a wall of a region of a digestive tract.2. The capsule of claim 1 , wherein each of the pairs comprises a first probe and a second probe claim 1 , the first probe configured to range a first distance to a first side of the wall of the region of the digestive tract along a first direction and the second probe configured to range a second distance to a second side of the wall along an opposite direction to the first direction; an angle between the first and second directions is smaller than a threshold.3. The capsule of claim 1 , wherein the capsule or a first apparatus linked to the capsule through communication is configured to obtain morphological features from the data.4. The capsule of claim 3 , the morphological features comprising one or more of location claim 3 , volume claim 3 , curvature and diameter of the region.5. The capsule of claim 3 , wherein the capsule or the first apparatus or a second apparatus is configured to obtain parameters of motility ...

Method for controlling flow of intestinal contents in a patient's intestines

There is provided a method for controlling a flow of intestinal contents in the intestinal passageway of a patient's intestines. The method comprises gently constricting (i.e., without substantially hampering the blood circulation in the intestinal tissue wall) at least one portion of the intestinal tissue wall to influence the flow in the intestinal passageway, and stimulating the constricted wall portion to cause contraction of the wall portion to further influence the flow in the intestinal passageway. The method can be used for restricting or stopping the flow in the intestinal passageway, or for actively moving the fluid in the intestinal passageway, with a low risk of injuring the intestines.

SYSTEM AND METHOD OF MONITORING CONDITION OF EQUINES

A system for behavioral monitoring for equines, comprising at least one sensor to measure a signal related to the equine, a database to store at least one parameter of the equine as a function of time, and processing means. The sensor is in communication with the equine, and comprises a wireless transmitter which is in communication with the data-base. The processing means, in communication with the database, is adapted to (i) determine, from at least one signal from the at least one sensor, at least one parameter of the equine as a function of time; (ii) establish normal behavior of the equine based on the parameter; and (iii) identify at least one abnormal behavior of the equine by identifying at least one deviation from normal behavior. 1104-. (canceled)105. A system for behavioral monitoring for equines , comprising:a. at least one first sensor, comprising at least one first wireless transmitter; said at least one first sensor is in communication with said equine;b. a database in communication with said at least one first transmitter, said database adapted to store at least one parameter of said equine as a function of time; and,c. processing means in communication with said database, said processing means adapted to (i) determine, from at least one signal from said at least one sensor, said at least one parameter of said equine as a function of time; (ii) establish normal behavior of said equine based on said parameter of said equine as a function of time; and (iii) identify at least one abnormal behavior of said equine by identifying at least one deviation from said normal behaviorwherein said abnormal behavior is selected from colic, silent colic, getting cast, silent cast, undiagnosed injury, not getting sufficient REM sleep, getting too much REM sleep, and any combination thereof.106. The system of claim 105 , wherein at least one of said colic and said silent colic is identifiable by behavior selected from a group consisting of: repeated rolling and ...

A PELVIC FLOOR MUSCLE TRAINING AND PROFILING APPARATUS FOR INSERTING INTO A BODY CAVITY OF A HUMAN AND A METHOD FOR VISUALIZING PELVIC FLOOR MUSCLE CONTRACTIONS

A pelvic floor muscle training and profiling apparatus for inserting into a body cavity of a human, said apparatus comprising; a body having a distal end, an opposite proximal end and an outer surface, the body extending between said ends, a sensor array encompassed in the body, the sensor array comprising a sensor unit, the sensor unit being adapted for detecting an exterior force applied to the outer surface of the body, a micro-control unit adapted to receive sensor data from the sensor array, wherein the sensor unit is adapted for detecting a specific position of the exterior force applied to the outer surface of the body. 1. A pelvic floor muscle training and profiling apparatus for inserting into a body cavity of a human , said apparatus comprising:a body having a distal end, an opposite proximal end and an outer surface, the body extending between said ends,a sensor array encompassed in the body, the sensor array comprising a sensor unit, the sensor unit being adapted for detecting an exterior force applied to the outer surface of the body,a micro-control unit adapted to receive sensor data from the sensor array, characterized in that the apparatus further comprises a top sensor arranged in the distal end of the body, and the sensor unit is adapted for detecting a specific position of the exterior force applied to the outer surface of the body.2. The apparatus according to claim 1 , wherein the sensor unit measures the relative magnitude of the exterior force applied to the body.3. The apparatus according to claim 1 , wherein the sensor unit comprises two points of measurements placed at a maximum distance to each other of less than 0.3 cm.4. The apparatus according to claim 1 , wherein at least one sensor unit is a force sensor.5. The apparatus according to claim 1 , wherein the sensor unit measures a relative distributed force applied to said sensor unit from a muscle contraction.6. The apparatus according to claim 1 , wherein the sensor unit comprises at ...

SYSTEM AND METHOD FOR CORE BODY TEMPERATURE MEASUREMENT

A core body temperature monitoring system comprises a first, core body temperature, thermometer and a second thermometer comprising a heat flux sensor. The second thermometer is for application to the skin for providing temperature monitoring over time. The second thermometer is calibrated using an output from the first core body temperature thermometer during an initial measurement operation. The first thermometer is removably attached to the second thermometer, wherein the first thermometer is adapted for use while attached to the second thermometer, and is then removed when the second thermometer is to be used. This system provides calibration of a flux sensor which is applied to the skin, by using an initial core body temperature measurement. In this way, the functionality and usage of a classic core body temperature thermometer is combined with a wearable continuous monitoring capability. 1. A core body temperature monitoring system , comprising:a first core body temperature thermometer;a second thermometer comprising a heat flux sensor, wherein the heat flux sensor comprises a pad for application to the skin for providing temperature monitoring over time; anda controller for calibrating the second thermometer using an output from the first thermometer during an initial measurement operation,wherein the first thermometer is removably attached to the second thermometer, wherein the first thermometer is adapted for use while attached to the second thermometer, and the second thermometer is adapted for use when detached from the first thermometer.2. A system as claimed in claim 1 , wherein the controller is adapted to determine the thermal resistance of the body and thereby to calibrate the second thermometer.3. A system as claimed in claim 1 , wherein the second thermometer comprises a first temperature sensor for application to the skin and a second temperature sensor spaced from the first temperature sensor by an insulator layer of known thermal resistivity.4. ...

LUMEN PASSABILITY CHECKING DEVICE

A lumen passability checking device checks whether a capsule medical device configured to be introduced into a gastrointestinal tract of a subject is allowed to pass through the gastrointestinal tract. The device includes: a main body dissolvable by a substance in the gastrointestinal tract; a first layer coating the main body, having an outer diameter substantially equivalent to an outer diameter in a minor axis of the capsule medical device, and being dissolvable by the substance in the gastrointestinal tract; and a second layer coating the first layer and being dissolvable by the substance in the gastrointestinal tract. The first and second layers contain different discriminating materials. The first layer has at least two regions extending along a circumference of a cross section of the first layer, the cross section intersecting with a long axis of the device, a part of each region being thinner than other parts. 1. A lumen passability checking device for checking whether a capsule medical device configured to be introduced into a gastrointestinal tract of a subject is allowed to pass through the gastrointestinal tract , the device comprising:a main body made of a material dissolvable by a substance existing in the gastrointestinal tract;a first dissolving layer coating a surface of the main body, having an outer diameter substantially equivalent to an outer diameter in a minor axis of the capsule medical device, and being made of a material dissolvable by the substance existing in the gastrointestinal tract; anda second dissolving layer coating a surface of the first dissolving layer and being made of a material dissolvable by the substance existing in the gastrointestinal tract, whereinthe first and second dissolving layers contain different discriminating materials, andthe first dissolving layer has at least two regions extending along a circumference of a cross section of the first dissolving layer, the cross section intersecting with a long axis of the ...

SYSTEM AND METHOD FOR ASSESSING BOWEL HEALTH

In accordance with one aspect of the present technique, a method includes receiving a plurality of images of an abdominal region from an image capture device. The method further includes identifying a bowel tissue and a peristaltic portion of the bowel tissue from the plurality of images. The method further includes determining a peristalsis property of the bowel tissue based on the peristaltic portion. The peristalsis property includes at least one of a percentage of the peristaltic portion within the bowel tissue and an amount of peristalsis in the peristaltic portion. The method also includes assessing a health the bowel tissue based on the peristalsis property of the peristaltic portion. 1. A method comprising:receiving a plurality of images of an abdominal region from an image capture device;identifying a bowel tissue from at least one of the plurality of images;identifying a peristaltic portion of the bowel tissue from the plurality of images;determining a peristalsis property of the bowel tissue based on the peristaltic portion, wherein the peristalsis property includes at least one of a percentage of the peristaltic portion within the bowel tissue and an amount of peristalsis in the peristaltic portion; andassessing a health of the bowel tissue based on the peristalsis property of the peristaltic portion.2. The method of claim 1 , wherein assessing the health of the bowel tissue further comprises calculating a health score of the bowel tissue based on the peristalsis property of the peristaltic portion.3. The method of claim 2 , further comprising:determining a physical characteristic of the bowel tissue from the plurality of images; andcalculating the health score of the bowel tissue based on the physical characteristic.4. The method of claim 3 , wherein the physical characteristic includes at least one of an acoustic response and an elasticity of the bowel tissue.5. The method of claim 2 , further comprising:determining a blood flow characteristic of the ...

ENDOSCOPIC SMART PROBE AND METHOD

An improved endoscopic device which is introduced into, for example, the intestinal tract of a living organism and which operates autonomously therein, adapted to obtain and store or transmit one or more types of data such as visual image data, laser autofluorescence data, pressure data, or ultrasonic waveform data. In one embodiment, the device includes one or more pressure sensing apparatus configured to enable measurement of pressure resulting from, for instance, peristaltic contractions within the intestinal tract, including transmission of pressure data as a function of time off of the device via a wireless interface while the device is within the intestinal tract. 115.-. (canceled)16. An electronic probe for use within a human being , said electronic probe comprising:a housing with an exterior shape and at least one an exterior surface;at least one pressure sensing apparatus in communication with at least a portion of the housing; andcircuitry in signal communication with the at least one pressure sensing apparatus and configured to generate data based at least in part on a pressure being applied to said at least one pressure sensing apparatus while said probe is within said human being.17. The probe of claim 16 , wherein the use within a human being comprises use within an intestinal tract of the human being claim 16 , and the probe is configured to perform said generation of data based on sensing one or more peristaltic contractions within said intestinal tract.18. The probe of claim 17 , further comprising a wireless transmitter in communication with said circuitry and configured to generate radio frequency energy encoding at least a portion of said generated data.19. The probe of claim 18 , wherein the wireless transmitter comprises a transmitter complaint with an RFID (radio frequency identification) standard.20. The probe of claim 16 , further comprising a wireless apparatus in communication with said circuitry and configured to transmit radio frequency ...

TREATMENT OF FECAL INCONTINENCE

Methods and devices to diagnose and treat fecal incontinence in females and males are provided. A multiple sensor-enabled catheter for positioning in a patient's rectum allows for the visualization and manipulation or positioning of an anatomical reference point(s) in the patient's body. A multiple sensor-enabled catheter for rectal insertion in a patient allows for the visualization and implementation of efficient and effective exercises to strengthen pelvic floor muscles. 1. A method for the diagnosis or treatment of fecal incontinence comprising positioning in the rectum of a patient a multiple sensor-enabled catheter , visualizing the anatomical state of the patient , and manipulating the patient's body to a position capable of relieving the incontinence.2. The method of claim 1 , wherein the anatomical state is the relative position of at least one patient anatomical reference points selected from the group consisting of the pubic bone claim 1 , the coccyx claim 1 , the bladder claim 1 , the urethra claim 1 , the uterus claim 1 , the prostate claim 1 , and the rectum.3. The method of claim 1 , wherein the anatomical state is the muscular function of the rectal sphincter.4. The method of claim 1 , wherein the anatomical state is the muscular function of the pelvic floor.5. The method of claim 1 , wherein the manipulating is done by the patient. This application is a continuation-in-part application of U.S. patent application No. 14/359,890, entitled “Treatment of Urinary Incontinence,” filed May 21, 2014, which claims priority to international patent application PCT/US2012/066613, filed Nov. 27, 2012, and U.S. provisional patent application Ser. No. 61/563,889, filed Nov. 28, 2011, the entireties of which are incorporated herein by reference for all purposes.The present embodiments relate to the devices, diagnosis, and treatment of fecal incontinence in females and males. The diagnosis and treatment may involve the use of a multiple sensor-enabled catheter ...

BIO-IMPEDANCE MEASUREMENT METHOD USING BI-PHASIC CURRENT STIMULUS EXCITATION FOR IMPLANTABLE STIMULATOR

Method and apparatus for estimating bio-impedance at electrode-electrolyte interface by injecting a single low-intensity bi-phasic current stimulus having an selected inter-pulse delay first and second current pulse phases, which involves acquiring transient electrode voltage along the bi-phasic current stimulus waveform. Determining equivalent circuit parameters of an electrode, at the electrode-electrolyte/tissue interface, based on transient electrode voltage across said multiple temporal locations is also performed. 1. A bio-impedance measuring apparatus , comprising:(a) an electrode stimulus circuit configured for generating a low-intensity bi-phasic current stimulus to an attached electrode;(b) wherein said bi-phasic current stimulus comprises a first phase of a first polarity, an interphase delay, and is followed by a second phase of a second polarity;(c) an analog to digital converter configured for coupling to said electrode for registering voltage waveforms arising in response to said bi-phasic current stimulus;(d) at least one processor; and(e) a memory storing instructions executable by the at least one processor; (i) acquiring transient electrode voltages at multiple points during said bi-phasic current stimulus; and', '(ii) determining parameters of electrode equivalent circuit in response to analyzing said transient electrode voltages with respect to said bi-phasic current stimulus and its inter-pulse delay., '(f) said instructions when executed by the at least one processor performing steps comprising2. The apparatus as recited in claim 1 , wherein said bio-impedance are determined by determining equivalent circuit parameters of an electrode at the electrode-electrolyte/tissue interface.3. The apparatus as recited in claim 1 , wherein said bio-impedance comprises impedance at the electrode-electrolyte/tissue interface in a biological organism or system.4. The apparatus as recited in claim 1 , wherein said multiple points to acquire voltages comprise ...

N-myristoyltransferase 2 Overexpression in Peripheral Blood and Peripheral Blood Mononuclear Cells is a Marker for Colorectal Cancer

Described herein is the Identification of the NMT isozyme overexpressed in PBMCs of colorectal cancer patients and the cell types overexpressing NMT2 in the PBMCs of CRC patients. 1. A method of determining if an individual is a candidate for further colorectal cancer screening comprising:obtaining a whole blood sample from the individual;measuring NMT2 level in the whole blood sample;comparing the measured NMT2 level to an NMT2 threshold level; andperforming a sigmoidoscopy or colonoscopy on the individual if the measured NMT2 levels are greater than the NMT2 threshold level.2. The method according to wherein the individual is selected from the group consisting of an individual at risk of developing colorectal cancer claim 1 , an individual suspected of having colorectal cancer; an individual over age 55; and an individual having a familial history of colorectal cancer.3. The method according to wherein the NMT levels are measured using a primer comprising nucleic acid sequence unique to NMT2.4. The method according to wherein the NMT levels are measured using a probe comprising nucleic acid sequence unique to NMT2.5. The method according to wherein the NMT levels are measured using an antibody specific for NMT2.6. The method according to wherein the patient is a human.7. The method according to wherein the whole blood sample comprises peripheral blood monocyte cells isolated from whole blood.8. The method according to wherein the whole blood sample comprises T-cells isolated from whole blood.9. The method according to wherein the whole blood sample comprises CD8+ cells isolated from whole blood.10. The method according to wherein the whole blood sample comprises CD4 cells isolated from whole blood.11. The method according to wherein NMT2 levels are measured with the proviso that no NMT1 levels are measured simultaneously.12. The method according to including performing a biopsy on any tissue sample removed during the sigmoidoscopy or colonoscopy for diagnosing ...

IN VIVO IMMUNOASSAY SYSTEM

A swallowable in-vivo device comprising a shell defining a cavity of the in-vivo device, the shell being formed with at least one aperture extending through the shell's wall. The in-vivo device is configured for allowing inlet of fluid into the cavity; The in in-vivo device further comprises and immunoassay system accommodated within the cavity and configured for interacting within the fluid; The in-vivo device also comprises at least one breach mechanism covering the at least one inlet for preventing ingress of fluids into the cavity via the inlet; The at least one breach mechanism comprises a film layer configured for reacting with the fluid and designed to be breached after a predetermined amount of exposure time to the GI fluid, corresponding to a desired location along the GI tract. 1. A swallowable in-vivo device , comprising:a shell defining a cavity of the in-vivo device, the shell being formed with at least one aperture extending therethrough and configured for allowing ingress of fluid into the cavity;an immunoassay system disposed within the cavity and configured for interacting with fluid; andat least one breach mechanism covering the at least one aperture for preventing ingress of fluid into the cavity via the inlet, the at least one breach mechanism including a film layer configured for reacting with the fluid and configured to be breached after a predetermined amount of exposure time to gastrointestinal (GI) fluid of a person, the predetermined amount of exposure time corresponding to travel of the in-vivo device along the person's GI tract to a desired location along the person's GI tract.23-. (canceled)4. The swallowable in-vivo device according to claim 1 , wherein the film layer is formed as a stand-alone component.5. (canceled)6. The swallowable in-vivo device according to claim 1 , wherein the film layer is configured to erode over a period of exposure time to the GI fluid.7. The swallowable in-vivo device according to claim 1 , wherein the film ...

APPLICATION-SPECIFIC INGESTIBLE APPARATUS FOR IN VIVO DATA COLLECTION AND PROCESSING

A device which is introduced into the intestinal tract of a living organism and which operates autonomously therein, adapted to obtain data using a sensor apparatus (such as an imaging device), and process the data using an onboard processor core. In one embodiment, the processor core comprises a RISC core with an extension instruction set, the extension instructions of which are specifically selected to optimize the data processing, as well as reducing the power consumption of an integrated circuit of which the core is part (such as by way of reducing gate count in the integrated circuit through elimination of unnecessary core functions). 114.-. (canceled)15. A user-configured probe for autonomously operating within the intestinal tract of a living organism , comprising:at least one sensor capable of collecting information relating to said organism;a power supply;a data processor in data communication with the at least one sensor and powered at least in part by the power supply; anda communications device in data communication with the data processor;wherein said data processor comprises a custom core synthesized at least in part through selection by the user of one or more extension instructions specifically adapted for processing data generated by the at least one sensor.16. The probe of claim 15 , wherein said data processor core is optimized for reduced power consumption.17. The probe of claim 16 , wherein said optimization comprises the core having a plurality of sleep modes claim 16 , at least one of the plurality which causes at least a portion of the core to consume less electrical power than when said core is not in said mode.18. The probe of claim 17 , wherein said at least one sleep mode is entered or exited via at least one signal generated internal to said probe claim 17 , said at least one signal relating to the operation of the at least one sensor.19. The probe of claim 16 , wherein said optimization comprises the core having at least one functional ...

CONSTITUTIONAL DISEASE PATTERN DETERMINATION METHOD AND APPARATUS

Provided is a constitutional disease pattern determination apparatus including a calculator to calculate a first deficiency and excess index and a first cold and heat condition index of a user based on clinical information on the user, and a determiner to determine, based on a first reference table corresponding to a first constitution, a first constitutional disease pattern corresponding to the first deficiency and excess index and the first cold and heat condition index among a plurality of constitutional disease patterns included in the first reference table, wherein the first constitution is a constitution classified to correspond to the user based on a Sasang constitution. 1. A constitutional disease pattern determination apparatus comprising:a calculator to calculate a first deficiency and excess index and a first cold and heat condition index of a user based on clinical information on the user; anda determiner to determine, based on a first reference table corresponding to a first constitution, a first constitutional disease pattern corresponding to the first deficiency and excess index and the first cold and heat condition index among a plurality of constitutional disease patterns included in the first reference table,wherein the first constitution is a constitution classified to correspond to the user based on a Sasang constitution.2. The apparatus of claim 1 , wherein the first reference table corresponds to user demographic information claim 1 , and the user demographic information comprises at least one of a gender and an age of the user.3. The apparatus of claim 1 , further comprising:a selector to select the first reference table corresponding to the first constitution from among a plurality of reference tables corresponding to a plurality of constitutions classified based on the Sasang constitution.4. The apparatus of claim 1 , wherein the determiner determines a constitutional disease pattern having a minimum geometric distance from a first point ...

MOTILITY MANOMETER PRIMING MANIFOLD SYSTEM WITH ICON-BASED USER INTERFACE AND WIRELESS CONNECTIVITY

A catheter includes a distal distension balloon and circumferentially arranged motility measurement balloons proximal of the distension balloon. A manifold includes balloon ports each configured to fluidly couple to a motility measurement balloon, pressure transducer ports, and a priming port. A port selector is coupled to the manifold and movable between different positions. Each port selector position causes the manifold to establish different fluidic couplings between the respective motility balloon, pressure transducer, and priming ports. A pressure sensing device includes pressure transducers each fluidly coupled to one of the pressure transducer ports. The pressure sensing device is configured to coordinate calibration of the pressure transducers at atmospheric pressure with the port selector in a first position and motility balloon pressure measurements with the port selector in a third position. Priming of the motility measurement balloons is implemented by moving the port selector to a second position. 1. A system , comprising:a catheter comprising a distal distension balloon and a plurality of circumferentially arranged motility measurement balloons proximal of the distension balloon; a plurality of balloon ports each configured to fluidly couple to one of the motility measurement balloons;', 'a plurality of pressure transducer ports; and', 'a priming port;, 'a manifold comprisinga port selector coupled to the manifold and movable between different positions, each of the different port selector positions causing the manifold to establish different fluidic couplings between the respective motility balloon, pressure transducer, and priming ports; anda pressure sensing device comprising a plurality of pressure transducers each fluidly coupled to one of the plurality of pressure transducer ports, the pressure sensing device configured to coordinate calibration of the pressure transducers at atmospheric pressure with the port selector in a first position and ...

METHODS AND SYSTEMS FOR BLOCKING NEURAL ACTIVITY IN AN ORGAN OF A SUBJECT, PREFERABLY IN THE SMALL INTESTINE OR THE DUODENUM

The present disclosure provides, according to some embodiments, methods and systems for selectively reducing, blocking or inhibiting at least part of the neural activity in an organ of a subject. In preferred embodiments, the method and system are used for selectively blocking at least part of the neural activity in a duodenum of a subject in need thereof. According to some embodiments, the selective blocking occurs through use of laser radiation. According to some embodiments, the selective blocking occurs through use of ultrasound energy. According to some embodiments, the selective blocking comprises causing damage to at least part of sensory nerves located within a target area while maintaining functional activity of tissue surrounding the sensory nerves by means of shielding it from the effects of laser radiation. According to some embodiments, the sensory nerves include neurons configured to transmit signals triggered by food passing through the duodenum, such as, but not limited to, neurohormonal signals. 1111.-. (canceled)112. A method for reducing neural activity in a duodenum of a subject , the method comprising:introducing ultrasound transducer into the duodenum of the subject;{'sup': '2', 'emitting a focused ultrasound beam at a frequency in a range of 5 MHz to 50 MHz and at an intensity of 5 to 300 Watt/cmwherein the ultrasound beam is configured to be absorbed by different layers of the duodenum in the target area;'}lowering a temperature of the target area utilizing a cooling mechanism, thereby causing selective ablation of sensory nerves located in the target area's submucosal layer to at least partially reduce the neural activity within the submucosal layer while maintaining functional activity of the mucosal layer within the treated target area and/or surrounding the treated target area.113. The method of claim 112 , wherein the focused ultrasound beam emitted is selected from a high-intensity focused ultrasound (HIFU) beam claim 112 , a ...

METHODS AND ARTICLES FOR DELIVERING VIABLE CELLS INTO SOLID TISSUE

Embodiments provide swallowable devices, preparations and methods for delivering viable cells (VC) into the GI tract including GI wall tissue or other tissue site. Particular embodiments provide a swallowable device such as a capsule for delivering VC into an intestinal wall or other site. The VC can be contained within a tissue-penetrating shell disposed in the capsule that protects the VC as they pass through the GI tract until they are inserted into GI tract tissue or other location. The shell desirably has shape, size and material consistency to be contained in a swallowable capsule, delivered from the capsule into solid tissue by the application of force on the shell and biodegrade within the solid tissue to release the VC into the tissue. Within the shell or other structure the VC can be maintained in a viability-sustaining gel that preserves the viability of the VC for selected time periods. 1. (canceled)2. A method for producing a therapeutic effect in a patient , the method comprising:swallowing an enclosure containing a tissue penetrating article which contains a mass of viable cells, wherein the article passes through the gastrointestinal tract with the article intact and the cells remaining viable;releasing the article from the enclosure in response to a condition in the gastrointestinal tract; andpropelling the article to penetrate into gastrointestinal tissue and releasing the cells or substances produced by the cells to produce the therapeutic effect in the patient.3. The method of claim 2 , wherein the therapeutic effect is glucose regulation.4. The method of claim 2 , wherein the therapeutic effect is a production of insulin within the patient's body.5. The method of claim 2 , wherein the therapeutic effect is a production of an incretin within the patient's body.6. The method of claim 2 , wherein the therapeutic effect is a production of gastrin within the patient's body.7. The method of claim 2 , wherein the therapeutic effect is an effect on the ...

THERAPEUTIC UNDERGARMENTS FOR THE TREATMENT OF FUNCTIONAL GASTROINTESTINAL DISORDERS INCLUDING IRRITABLE BOWEL SYNDROME

An apparatus, system, and method for treating symptoms of IBS. The apparatus includes a base material comprising a material that fits to the body of a user, an elastic portion capable of applying compression across the abdomen of a user, and a tension adjusting mechanism for adjusting the compression applied to the abdomen in order to treat the symptoms of IBS. A system for treating IBS may include a processor configured to receive a first set of data from biosensors configured to measure contractions in the bowel, receive a second set of data from a galvanic skin response sensor configured to measure electrical conductance of the skin; and, analyze patterns between the first and second sets of data. 1. Apparatus for treating symptoms of Irritable Bowel Syndrome (IBS) , comprising:a base material comprising a material that fits to the body of a user;an elastic portion capable of applying compression across the abdomen of a user; anda tension adjusting mechanism for adjusting the compression applied to the abdomen in order to treat the symptoms of IBS.2. The apparatus of claim 1 , wherein the tension adjusting mechanism is capable of adjusting the compression to apply a lower abdominal pressure and additional claim 1 , targeted pressure to a sigmoid and descending colon of the user.3. The apparatus of claim 2 , wherein the apparatus comprises an undergarment.4. The apparatus of claim 2 , wherein the tension adjusting mechanism comprises multiple connector strips attached to the base material and corresponding receiving strips that enable the connector strips to be fastened in an adjustable manner to adjust the compression applied to the abdomen.5. The apparatus of claim 2 , wherein the tension adjusting mechanism comprises an elastic strap attached to the base material at an angle such that the elastic strap wraps from a first position around the back of the user to a second position located higher than the first position.6. The apparatus of claim 1 , further ...

METHOD FOR DETECTING DISEASE USING HIGH RESOLUTION MANOMETRY, AND APPARATUS THEREOF

A method for detecting disease using a manometry includes obtaining pressure values from each of the plurality of pressure sensors during a pre-set time, obtaining a three-dimensional pressure distribution showing the changes in the pressure values according to location and time by using the time, the pressure values, and locations in which the pressure sensors are disposed within the arbitrary location section, and calculating the volume integral value of the interest location which is predetermined in accordance with the disease, in the three-dimensional pressure distribution. 1. A method for detecting anus diseases using a manometry that a plurality of pressure sensors are disposed at determined intervals along an arbitrary location section in a length direction , comprising;obtaining pressure values from each of the plurality of pressure sensors during a predetermined time;obtaining a three-dimensional pressure distribution showing the changes of the pressure values according to location and time by using the time, the pressure values, and locations in which the pressure sensors are disposed within the arbitrary location section; andcalculating the volume integral value of the interest location which is predetermined in accordance with the disease within the three-dimensional pressure distribution.2. The method for detecting anus diseases using a manometry of claim 1 , wherein the arbitrary location section includes a first section corresponding to a rectum area and a second section corresponding to an anus area while the manometry is inserted claim 1 , andin the calculating the volume integral value, in a case that the disease is constipation, the first section is set to the interest location to calculate the volume integral value and in a case that the disease is fecal incontinence, the second section is set to the interest location to calculate the volume integral value.3. The method for detecting anus diseases using a manometry of claim 2 , further ...

SYSTEMS, METHODS AND DEVICES FOR PREDICTING AND DETECTING POSTOPERATIVE COMPLICATIONS

A monitoring device includes an input port attachable for fluid communication with a catheter, the catheter for insertion in a body of a user, for receiving fluid from the body of the user, an output port, generally parallel to the input port, in fluid communication with a fluid reservoir, a fluid channel defining fluid communication between the input port and the output port, and a biosensor for continuously measuring bio-signal data of the fluid in the fluid channel, the biosensor including an electrode pair. The biosensor is in communication with a computing device for determining a condition of the user based at least in part on the bio-signal data. 125-. (canceled)26. A monitoring device comprising:an input port, attachable to a catheter for insertion in a body of a user, the input port in fluid communication with the catheter for receiving fluid from the body of the user;an output port in fluid communication with a fluid reservoir;a fluid channel defining fluid communication between the input port and the output port; anda biosensor, in communication with a computing device, for continuously measuring bio-signal data of the fluid in the fluid channel.27. The monitoring device of claim 26 , wherein the output port is generally parallel to the input port.28. The monitoring device of claim 26 , wherein the computing device is for determining a condition of the user based at least in part on the bio-signal data.29. The monitoring device of claim 26 , wherein the biosensor includes an impedance sensor for detecting an impedance or conductivity of the fluid in the fluid channel.30. The monitoring device of claim 26 , wherein the biosensor includes a pH sensor for detecting a pH level in the fluid in the fluid channel.31. The monitoring device of claim 26 , wherein the biosensor includes at least one of a lactate sensor claim 26 , an amylase sensor claim 26 , a urea sensor claim 26 , or a creatinine sensor.32. The monitoring device of claim 26 , wherein the biosensor ...

Ingestible capsule for the phototherapeutic treatment of infections

An ingestible capsule arranged, in use, to cross a human stomach for carrying out a phototherapic treatment arranged to combat an infection due to the presence of the bacterium Helicobacter pylori, said ingestible capsule comprising at least one primary light source arranged to emit an electromagnetic phototherapic wave having a wavelength λ1, at least one auxiliary light source arranged to emit an electromagnetic phototherapic wave having a wavelength λ2, a wrapper arranged to contain said or each primary light source and said or each auxiliary light source, said wrapper being at least partially transparent to said wavelengths λ1 and λ2, a control unit arranged to selectively activate said or each primary light source and/or said or each auxiliary light source, and at least one energy source arranged to provide energy for feeding said control unit and/or said light sources. In particular, 400 nm<λ1<525 nm and 525 nm<λ2<650 nm. Furthermore, said control unit is configured to receive an information of position reporting in real time an area of said stomach crossed by said ingestible capsule; to determine, known said information of position, a wavelength, a dosage and a duration of administration of said electromagnetic phototherapic waves for an optimal phototherapic treatment of said area of said stomach; to selectively activate said or each primary light source and/or said or each auxiliary light source to provide said optimal phototherapic treatment of said area of said stomach.

DIAGNOSTIC ASSISTANCE METHOD, DIAGNOSTIC ASSISTANCE SYSTEM, DIAGNOSTIC ASSISTANCE PROGRAM, AND COMPUTER-READABLE RECORDING MEDIUM STORING THEREIN DIAGNOSTIC ASSISTANCE PROGRAM FOR DISEASE BASED ON ENDOSCOPIC IMAGE OF DIGESTIVE ORGAN

A diagnostic assistance method for a disease based on an endoscopic image of a digestive organ with use of a convolutional neural network (CNN). A diagnostic assistance method for a disease based on an endoscopic image of a digestive organ with a CNN trains the CNN using a first endoscopic image of the digestive organ and at least one final diagnosis result on positivity or negativity to the disease in the digestive organ, a past disease, a severity level, and information corresponding to a site where an image is captured, the final diagnosis result corresponding to the first endoscopic image, and the trained CNN outputs at least one of a probability of the positivity and/or the negativity to the disease, a probability of the past disease, a severity level of the disease, an invasion depth of the disease, and a probability corresponding to the site where the image is captured. 132-. (canceled)33. A diagnostic assistance method for a disease based on an endoscopic image of a digestive organ with use of a convolutional neural network , the diagnostic assistance method comprising: a first endoscopic image of the digestive organ; and', 'at least one final diagnosis result on positivity or negativity to the disease in the digestive organ, a past disease, a severity level, an invasion depth of the disease, and information corresponding to a site where an image is captured, the final diagnosis result being corresponding to the first endoscopic image, wherein, 'training the convolutional neural network usingthe trained convolutional neural network outputs at least one of a probability of the positivity and/or the negativity to the disease in the digestive organ, a probability of the past disease, a severity level of the disease, an invasion depth of the disease, and a probability corresponding to the site where the image is captured, based on a second endoscopic image of the digestive organ.34. The diagnostic assistance method for a disease based on an endoscopic image of a ...

Optical capsule and spectroscopic method for treating and diagnosing the intestinal tract

A device and method for mapping, diagnosing and treating disorders or other diseases, disorders or conditions (e.g., bleeding, ischemic or necrotic tissue, and presence of certain chemicals or substances) of the intestinal tract is provided using a capsule passing through the intestinal tract and sensing optical characteristics as the capsule passes through. Further, a capsule tracking system is provided for tracking a capsule's location along the length of an intestinal tract as various treatment and/or sensing modalities are employed. In one variation, an acoustic signal is used to determine the location of the capsule. A map of optical characteristics may be derived from the pass of a capsule to diagnose the disorder or disease. The capsule or subsequently passed capsules may treat, further diagnose or mark the intestinal tract at a determined location along its length.

VAGINAL BIOMECHANICS ANALYZER

The present invention includes a device and method for measuring skin elasticity that comprises: a probe, wherein the probe comprises one or more holes, a vacuum source, a pressure sensor, and one or more proximity sensors aligned about the one or more holes; and a processor for recording the deformation of the skin using a control unit comprising a microcontroller connected to the proximity and the pressure sensors, wherein the proximity sensor and the processor is adapted to automatically initiate a test when the sensor is positioned at a pre-determined distance from the skin, wherein a vacuum in the probe is capable of pulling skin into the one or more holes and the proximity sensor is capable of measuring an amount of skin drawn into the one or more holes to determine an elasticity of the skin. 1. A device for measuring skin elasticity comprising:a probe, wherein the probe comprises one or more holes, a vacuum source, a pressure sensor, and one or more proximity sensors aligned about the one or more holes; anda processor for recording the deformation of the skin using a control unit comprising a microcontroller connected to the proximity and the pressure sensors, wherein the proximity sensor and the processor is adapted to automatically initiate a test when the sensor is positioned at a pre-determined distance from the skin, wherein a vacuum in the probe is capable of pulling skin into the one or more holes and the proximity sensor is capable of measuring an amount of skin drawn into the one or more holes to determine an elasticity of the skin.2. The device of claim 1 , wherein the control unit further comprises a switch claim 1 , an electronic control valve claim 1 , and a liquid crystal display claim 1 , and wherein the wand assembly is defined further as comprising a detachable handle and the probe.3. The device of claim 1 , wherein the control unit records and stores a vacuum data and a proximity sensor data.4. The device of claim 1 , wherein the proximity ...

DEVICE SUITABLE FOR BEING INGESTED AND ASSOCIATED SYSTEM

Device (), suitable for being ingested by a patient, comprising a disintegration matrix () that is designed to disintegrate in a digestive segment and a plurality of independent passive RFID markers () that are housed together in the disintegration matrix (), the disintegration matrix () being shaped so that when it disintegrates, the RFID markers () separate from one another and are no longer mechanically connected, so that each RFID marker () is able to move independently of the other RFID markers () in several segments of the digestive system of the patient, the RFID markers () each being, in the disintegration matrix (), protected by a hermetic encapsulation in a biocompatible material. 119-. (canceled)201. Device () , suitable for being ingested by a patient , and intended to determine a measurement of the digestive transit time of the patient and/or a spatial representation of the digestive transit of the patient ,{'b': 12', '11', '12, 'comprising a disintegration matrix () that is designed to disintegrate in a digestive segment and a plurality of independent passive RFID markers () that are housed together in the disintegration matrix (),'}{'b': '11', 'the RFID markers () being intended to mark the movement of the digestive chyme in the segments of the digestive system,'}{'b': 12', '11', '11', '11, 'the disintegration matrix () being shaped so that when it disintegrates the RFID markers () separate from one another and are no longer mechanically connected, so that each RFID marker () is able to move independently of the other RFID markers (),'}{'b': 11', '12, 'the RFID markers () each being, in the disintegration matrix (), protected by a hermetic encapsulation in a biocompatible material.'}21111. Device according to claim 20 , wherein the device () forms a hard capsule claim 20 , capsule claim 20 , pessary or tablet housing the RFID markers ().2211112. Device () according to claim 21 , wherein the RFID markers () are free to move in the matrix () which is a ...

EXTENDED BALLOON ASSEMBLY FOR A CATHETER

A balloon assembly for an anorectal manometry catheter may include a three-part tube and a balloon mountable on the tube. The three-part tube may include a flexible proximal connection tube (PCT), a flexible distal connection tube (DCT), and a semi-flexible transfer tube that is interposed between and connected to each of said PCT and said DCT. The balloon may have a first opening connected to a first end of the transfer tube and a second opening connected to a second end of the transfer tube which is opposite the first end of the transfer tube. The three-part tube may be configured to be slidable along and over a catheter in a first direction, with the DCT slid first. The three-part tube may also be configured to be slidable over the catheter in the opposite direction such that the PCT is folded onto itself and completely contained in the transfer tube. 1. A balloon assembly for an anorectal manometry catheter , comprising: a distal connection tube, and', 'a transfer tube lengthwise connected to said distal connection tube; and, 'an assembly tube to encircle a portion of a catheter and concentrically slidable over the catheter, the assembly tube comprisinga balloon having a first opening connected to a first end of the transfer tube and a second opening connected to a second end of the transfer tube.2. The balloon assembly as in claim 1 , wherein the assembly tube further comprises a proximal connection tube claim 1 , the transfer tube lengthwise interposed between the proximal connection tube and the distal connection tube.3. The balloon assembly as in claim 2 , wherein the proximal connection tube is at least partly foldable into the transfer tube.4. The balloon assembly as in claim 1 , wherein the balloon is inflatable through said transfer tube.5. The balloon assembly as in claim 4 , wherein the transfer tube comprises a hole or air passage to enable inflation of the balloon.6. The balloon assembly as in claim 1 , wherein the transfer tube includes a bulge.7. ...

INGESTIBLE DEVICE AND ASSOCIATED METHODS

An ingestible device is disclosed which can produce spectral data of one or more analytes, as well as associated methods for characterizing the gastrointestinal tract of a subject which contains such analytes. Related kits and systems are also disclosed. 1. (canceled)2. A method , comprising:providing an ingestible device including a spectrometer to obtain spectral data of at least one sample within a gastrointestinal (GI) tract of a subject in vivo;administering the ingestible device to the subject so that the ingestible device is disposed in the GI tract of the subject;obtaining spectral data of the at least one sample within the GI tract of a subject in vivo; andusing the spectral data to generate a digestive profile of the subject.3. The method of claim 2 , further including a processing unit configured to generate a digestion profile for the subject based on the spectral data claim 2 , and the method further comprising generating with the processing unit the digestion profile for the subject based on the spectral data.4. The method of claim 3 , wherein the ingestible device includes the processing unit therein.5. The method of claim 3 , wherein the processing unit is configured to compare the spectral data to one or more spectral standards to generate the digestion profile.6. The method of claim 5 , further comprising administering at least one ingestible standard claim 5 , at least one detection agent claim 5 , or a combination thereof claim 5 , to the subject claim 5 , the at least one ingestible standard claim 5 , at least one detection agent claim 5 , or a combination thereof providing the one or more spectral standards.7. The method of claim 6 , wherein the ingestible standard comprises a predetermined quantity of at least one macronutrient.8. The method of claim 7 , wherein the at least one macronutrient is an alcohol claim 7 , a carbohydrate claim 7 , a protein claim 7 , an amino acid claim 7 , or a fat.9. The method of claim 2 , wherein the digestion ...

SYSTEM FOR MONITORING ANASTOMOSES

A system for monitoring anastomoses, the system comprising a probe for interluminal insertion into a subject and a control module for connection to said probe, wherein: 118-. (canceled)19. A system for monitoring anastomoses , the system comprising:a probe for interluminal insertion into a subject; anda control module for connection to said probe, wherein:the probe comprises first and second optical sensor assemblies, said first and second optical sensor assemblies each comprising an optical emitter operable to emit light and an optical detector for detecting light emitted by said optical emitter, said first and second sensor assemblies being spaced from one another so that following insertion of said probe into a lumen of said subject said first sensor assembly can be utilized to interrogate a first limb of an anastomosis and said second sensor assembly can be utilized to interrogate a second limb of said anastomosis, andthe control module is configured to be capable of operating said optical emitters of said first and second optical sensor assemblies for to illuminate said first and second limbs of said anastomosis respectively, and to be capable of receiving signals from the optical detectors of said first and second optical sensor assemblies, signals from the optical detector of said first optical sensor assembly being representative of light reflected by tissue of said first limb of said anastomosis and signals from the optical detector of said second optical sensor assembly being representative of light reflected by tissue of said second limb of said anastomosis, said control module being further configured to compare the signals from the detectors of said first and second sensor assemblies with one another and derive therefrom an indication of tissue vitality in the lumen of either side of said anastomosis.20. The system according to claim 19 , wherein the optical emitters of said first and second sensor assemblies are substantially identical.21. The system ...

MANAGEMENT, ASSESSMENT AND TREATMENT PLANNING FOR INFLAMMATORY BOWEL DISEASE

Discussed herein is an image processing device and a corresponding method for assessing inflammatory bowel diseases. A plurality of dynamic MRI sequence of images of a bowel that include peristalsis information of the bowel and static MRI image(s) of the bowel that identify at areas of inflammation, stenosis, and increased mural thickness of the bowel are processed. A displacement of the bowel caused by respiration of the patient is conducted on the dynamic MRI sequences by performing a non-rigid registration. A peristaltic activity is determined by performing motion flow analysis on the dynamic sequences of images. A peristaltic activity of the static MRI image(s) based on a weighted sum of two closest dynamic MRI sequences of images is computed and the static image is combined with the closest dynamic MRI sequence of images by performing a multi-modal registration. 1 receive, a plurality of dynamic MRI sequence of images of a bowel of a patient, each MRI sequence of images including peristalsis information of the bowel,', 'receive at least one static MRI image of the bowel of the patient, wherein the static MRI image identifies at least one of areas of inflammation, stenosis, and increased mural thickness of the bowel,', 'compensate for a displacement of the bowel caused by respiration of the patient, by performing a non-rigid registration for each dynamic MRI sequence of images,', 'compute, for each dynamic MRI sequence of images, a peristaltic activity map by performing motion analysis on the MRI sequence of images,', 'determine a peristaltic activity for the at least one static MRI image based on a weighted sum of two closest dynamic MRI sequences of images, the two closest dynamic MRI sequences being determined based on a similarity measure of the static MRI image and the plurality of dynamic MRI sequences of images, and', 'combine the static MRI image and the closest dynamic MRI sequence of images by performing multi-modal registration of the static MRI image ...

BLADDER OR BOWEL DYSFUNCTION ASSESSMENT SYSTEMS AND METHODS

Systems and methods for the clinical diagnosis of functional bladder states and disorders based upon contractile frequencies and variability. Systems and methods are also provided for the clinical diagnosis of functional bowel states and disorders based upon contractile frequencies and variability. 1. A method for evaluating a state of at least one of a patient's bladder and a patient's bowel , the method comprising:receiving data indicative of contraction at least one of a patient's bladder and a patient's bowel over the course of a testing session in which at least one of the bladder and the bowel is monitored;analyzing low frequency, oscillatory signals in the received data; andcharacterizing the at least one of the bladder and the bowel based upon the analysis.2. The method of claim 1 , wherein the step of analyzing includes determining Spectral Power.3. The method of claim 1 , wherein the step of analyzing includes determining Weighted Average Frequency.4. The method of claim 1 , wherein the step of analyzing includes generating a CWT scalogram.5. The method of claim 1 , wherein the step of characterizing includes comparing the analyses with a predetermined model.6. The method of claim 1 , wherein the step of receiving data is performed while subjecting the patient to a filling test.7. The method of claim 1 , further comprising selecting at least one of therapeutic parameters claim 1 , dosages claim 1 , delivery of therapies claim 1 , treatment claim 1 , and effective timing of treatment to the patient based upon the characterization.8. The method of claim 7 , wherein the step of selecting is performed on a closed loop basis.9. The method of claim 1 , wherein the step of receiving includes receiving data indicative of contraction of the patient's bladder claim 1 , and further wherein the step of characterizing includes characterizing the patient's bladder based upon the analysis.10. The method of claim 1 , wherein the step of receiving includes receiving data ...

CONSTRUCTS FOR DIAGNOSING AND TREATING INFLAMMATORY BOWEL DISEASES AND COLON CANCER

The present invention features, inter alia, constructs for the delivery of therapeutic and diagnostic agents to a patient. The constructs can include a nanoparticle, a targeting agent that specifically binds a targeted tissue or cell, a therapeutic moiety, and a hydrogel. The constructs can be used in the treatment and diagnosis of bowel diseases, including inflammatory bowel disease (IBD) and colon cancer. In one embodiment, the therapeutic agent is a nucleic acid that mediates RNA inhibition (RNAi), and the invention is directed to treatments for IBD that combine the positive aspects of such agents {e.g., siRNAs) with the safety of a biodegradable polymeric delivery system to facilitate specific targeting of colonic tissues and cells. As the constructs can be formulated for oral administration, they are well tolerated and offer advantages with regard to patient compliance. 1. A drug delivery vehicle , wherein the vehicle comprises a plurality of nanoparticles , a targeting agent that specifically binds a targeted tissue , a therapeutic moiety , and a hydrogel , wherein the targeting agent and the therapeutic moiety are associated with the nanoparticles , thereby forming a core , and the hydrogel is generally peripheral to the core.2. The drug delivery vehicle of claim 1 , wherein the nanoparticles have a diameter in the range of about 1-1 claim 1 ,000 nm and or the nanoparticles comprise a naturally occurring polymer or a synthetic polymer.38.-. (canceled)9. The drug delivery vehicle of claim 1 , wherein the nanoparticles comprise a biodegradable polymer or a non-biodegradable polymer.1012.-. (canceled)13. The drug delivery vehicle of claim 1 , wherein the targeting agent comprises a receptor claim 1 , a receptor ligand claim 1 , a chemoattractant agent claim 1 , an extracellular matrix protein claim 1 , an antibody claim 1 , or a protein or peptide.14. (canceled)15. The drug delivery vehicle of claim 1 , wherein the targeting agent binds a cell or tissue within ...

DEVICES AND METHODS FOR DETERMINING BLOOD FLOW AROUND A BODY LUMEN

A system may include an expandable member, and a plurality of sensors disposed on an outer surface of the expandable member and circumferentially spaced apart from one another, wherein each of the plurality of sensors includes a first emitter configured to emit light of a first wavelength, and a detector configured to detect light, and a controller coupled to the plurality of sensors. 119-. (canceled)20. A medical device , comprising:a catheter;an optical sensor disposed at or adjacent to a distal end of the catheter, the optical sensor including a photodetector and one or more emitters, the photodetector and each of the one or more emitters of the optical sensor being disposed linearly along a longitudinal axis of the catheter; anda controller disposed within the catheter, the controller being configured to determine a thickness of tissue adjacent to the optical sensor based on input from the optical sensor.21. The medical device of claim 20 , wherein the catheter includes a circular cross-section along a proximal portion of the catheter claim 20 , and a semicircular cross-section along a distal portion of the catheter.22. The medical device of claim 21 , wherein the distal portion of the catheter includes a planar side surface and a rounded side surface claim 21 , with the optical sensor disposed on the planar side surface such that the photodetector and the one or more emitters are positioned flush relative to one another on the distal portion.23. The medical device of claim 22 , wherein the one or more emitters are configured to collect a diffusion gradient of reflected and absorbed light in the tissue adjacent to the optical sensor.24. The medical device of claim 23 , wherein the controller is configured to correlate measurements of the gradient of reflected and absorbed light with tissue thickness via a slope-ratio.25. The medical device of claim 24 , wherein each of the one or more emitters is positioned along the planar side surface at varying linear ...

MICRO-MOVEMENT AND GESTURE DETECTION USING RADAR

A movement detection device includes a signal transmission device configured to transmit a radar signal transmission toward a target area and to receive reflected radar signals, and a signal analysis device configured to analyze the reflected radar signals to detect a movement in the target area that is indicative of micro-shivering. In response to detecting the micro-shivering, the movement detection device generates an alarm. 1. A movement detection device , comprising:a signal transmission device configured to transmit a radar signal transmission toward a target area and to receive reflected radar signals; anda signal analysis device configured to analyze the reflected radar signals to detect a movement in the target area, wherein the movement is indicative of micro-shivering, andwherein in response to detecting the micro-shivering, the movement detection device generates an alarm to mitigate the detected micro-shivering.2. The movement detection device of claim 1 , wherein the movement detection device is configurable for use with a thermal sensor to confirm whether a patient's core temperature is changing in response to the micro-shivering.3. The movement detection device of claim 1 , further comprising an aiming device to optimize the direction of the radar signal transmission from the signal transmission device to an anatomical area of a subject in the target area.4. The movement detection device of claim 1 , wherein the signal transmission device transmits millimeter waves in the spectrum between about 30 GHz and about 300 GHz.5. The movement detection device of claim 1 , wherein the signal analysis device performs high-pass filtering to filter out breathing claim 1 , heart rate claim 1 , and patient body movement to enhance detection of the micro-shivering.6. The movement detection device of claim 5 , wherein a frequency range from 3 Hz to 20 Hz is filtered to detect the micro-shivering from the reflected radar signals.7. The movement detection device of ...

Computerized apparatus with ingestible probe

An endoscopic apparatus including a probe which is introduced into, for example, the intestinal tract of a living organism and which operates therein, adapted to perform one or more functions. In one embodiment, the probe communicates wirelessly with a portable electronic device outside the organism, the portable device which acts to relay data between the probe and a remote networked entity. In one variant, the probe includes an accelerometer to, for example, wake the probe up from a sleep mode when the organism is awake or ambulatory.

HEALTH AND LIFESTYLE PREDICTION

A detection system is provided for a distributed water infrastructure, where the system is configured to determine at least one of a human health or lifestyle state from water usage patterns in the distributed water infrastructure. The system may comprise at least one processor. The system may receive from at least one sensor associated with the distributed water infrastructure signals indicative of water usage in the distributed water infrastructure. The system may determine from the signals indicative of water usage a current water usage pattern. The system may access a database of a plurality of stored water usage patterns, where each at least one stored water usage pattern is associated with at least one human health or lifestyle state. The system may compare at least one current water usage pattern with at least some of the stored water usage patterns. The system may, based on the comparison, identify a human health or lifestyle condition reflected by the current water usage pattern. The system may institute a remedial action corresponding to the identified human health or lifestyle state. 1. A detection system for a distributed water infrastructure , wherein the system is configured to determine at least one of a human health or lifestyle state from water usage patterns in the distributed water infrastructure , the system comprising: receive from at least one sensor associated with the distributed water infrastructure signals indicative of water usage in the distributed water infrastructure;', 'determine from the signals indicative of water usage a current water usage pattern;', 'access a database of a plurality of stored water usage patterns, wherein each at least one stored water usage pattern is associated with at least one human health or lifestyle state;', 'compare at least one current water usage pattern with at least some of the stored water usage patterns;', 'based on the comparison, identify a human health or lifestyle condition reflected by the ...

AGENTS AND METHODS FOR DETERMINING COLORECTAL CANCER STATUS

The invention provides a method of determining the colorectal cancer status of subject, comprising applying to a colon and/or rectal surface an agent which is able to distinguish between a) mature glycosylated forms of MUC2 and b) incomplete or aberrant glycosylated forms of MUC2, and determining the extent to which the agent binds. 1. A method of determining the colorectal cancer status of subject , comprising applying to a colon and/or rectal surface an agent which is able to distinguish between a) mature glycosylated forms of Mucin 2 (MUC2) and b) incomplete or aberrant glycosylated forms of MUC2 , and determining the extent to which the agent binds.2. An agent which is able to distinguish between a) mature glycosylated forms of MUC2 and b) incomplete or aberrant glycosylated forms of MUC2.3. (canceled)4. A method of treating colorectal cancer or dysplasia in a subject comprising:i) topically applying to the colon and/or rectal region of a subject a labeled agent capable of binding predominantly to either mature glycosylated forms of MUC2 associated with healthy tissue or to incomplete or aberrant glycosylated forms of MUC2 associated with dysplasia or cancer;ii) visualizing the colorectal region to which the agent was applied and observing where the agent has bound; andiii) excising or treating tissue associated with the incomplete or aberrant glycosylated forms of MUC2.5. A kit for identifying cancerous or dysplastic colorectal tissue , or for determining the colorectal cancer status , in a subject comprising i) a labeled agent which binds predominantly to either mature glycosylated forms of MUC2 or to incomplete or aberrant glycosylated forms of MUC2; and ii) instructions to apply the labeled agent topically to the surface of the colon and/or rectal region of the subject.6. The method claim 1 , wherein the agent binds only claim 1 , or predominantly claim 1 , to mature glycosylated forms of MUC2; or wherein the agent binds only claim 1 , or predominantly claim ...

METHOD TO ASSESS PELVIC FLOOR MUSCLES INJURY, AND PROBE AND APPARATUS TO IMPLEMENT THE METHOD

The object of the present invention is the method to assess the pelvic floor muscle injury, comprising the steps of applying the measuring probe into the anus, generation of electric current signals of constant amplitude, using a current generator, and applying the signals into the pelvic floor muscles by means of application electrodes (EA) and (EA), detection of electric voltage signals from the pelvic floor muscles by means of a plurality of measuring electrodes (EP), EP EPn, analysis of electric current and voltage signals for amplitude values and phase dependencies of their waveform, wherein the electric current signals and the electric voltage signals from the pelvic bottom muscles constitute signals variable in time, of the frequencies ranging from 2 kHz to 200 kHz. The object of the invention is also an electrode based measuring probe and apparatus implementing the method of assessment pelvic floor muscles injury. 1. A method to assess the pelvic floor muscles injury , comprising the following steps:a) application of the probe into the rectum,{'b': 1', '2, 'b) generation, using a generator, of electric signals of constant amplitude and applying them into the pelvic floor muscles by means of application electrodes (EA) and (EA),'}{'b': 1', '2, 'c) detection of electric voltage signals from the pelvic floor muscles by means of a plurality of measuring electrodes (EP), (EP) . . . (EPn),'}d) analysis of electric current and voltage signals for amplitude values and phase dependencies of their waveform,characterized in that the electric current signal and the electric voltage signals from the pelvic bottom muscles constitute signals variable in time, of the frequencies ranging from 2 kHz to 200 kHz.2. The method of claim 1 , characterized in that the electric current signal and the electric voltage signals from the pelvic bottom muscles constitute signals variable in time claim 1 , of the frequencies ranging from 2 kHz to 50 kHz.3. The method of or claim 1 , ...

DIGESTIVE CANAL SCANNING DEVICE, BODY SCANNING DEVICE, BODY SCANNING METHOD AND ACOUSTIC-BASED DIGESTIVE ORGAN MONITORING SYSTEM

A digestive canal scanning device of the present invention includes a sensor module, a data processing unit, and an analysis unit. A body scanning device of the present invention includes a sensor module, a data processing unit, and an analysis unit. An acoustic digestive organ monitoring system of the present invention includes an auscultation unit, an artifact collection unit, a signal extraction unit, a feature extraction unit, a database, an artificial neural network, and a wireless communication unit. 1. A digestive canal scanning device comprising:a sensor module comprising multiple microphones attached to multiple sites separated from each other on the abdomen of a patient to detect sounds from the abdomen after the patient swallows food;a data processing unit converting analog signals generated from the multiple microphones into digital audio signals; andan analysis unit classifying a digestive canal sound among multiple audio signals converted by the data processing unit and recognizing that a location of a microphone detecting a signal classified as the digestive canal sound is a location at which the digestive canal sound is generated.2. The digestive canal scanning device according to claim 1 , wherein the sensor module comprises multiple unidirectional microphones; and an attachment pad attached to the patient abdomen and receiving the multiple microphones to be separated from each other.3. The digestive canal scanning device according to claim 2 , wherein the sensor module comprises a soundproof pad coupled to an inner surface of the attachment pad.4. The digestive canal scanning device according to claim 1 , wherein the analysis unit extracts locations claim 1 , at which the multiple audio signals are generated claim 1 , and treats an audio signal generated from a location separated a predetermined distance from locations at which other audio signals are generated claim 1 , as noise.5. The digestive canal scanning device according to claim 1 , wherein ...

Gastrointestinal Sensor Implantation System

A device includes an orally-administrable capsule and a tissue capture device coupled to the orally-administrable capsule. The tissue capture device is configured to connect to gastrointestinal tissue within a body. The tissue capture device is configured to detach from the orally-administrable capsule after the tissue capture device connects to the gastrointestinal tissue. A device includes an orally-administrable capsule, a tissue capture device coupled to the orally-administrable capsule, a chamber within the orally-administrable capsule, and an actuator. The tissue capture device includes multiple fasteners configured to connect the tissue capture device to gastrointestinal tissue within a body. The chamber is configured to draw gastrointestinal tissue towards the fasteners when a fluid pressure of the chamber is decreased. The actuator is configured to cause a decrease of the fluid pressure of the chamber. 1. A device comprising:an orally-administrable capsule; anda tissue capture device coupled to the orally-administrable capsule, the tissue capture device configured to connect to gastrointestinal tissue within a body,wherein the tissue capture device is configured to detach from the orally-administrable capsule after the tissue capture device connects to the gastrointestinal tissue.2. The device as recited in claim 1 , wherein the tissue capture device includes a plurality of fasteners configured to connect the tissue capture device to the gastrointestinal tissue.3. The device as recited in claim 2 , wherein each fastener of the plurality of fasteners is pointed inwardly from a first surface of the tissue capture device.4. The device as recited in claim 3 , wherein each fastener of the plurality of fasteners is disposed at an angle ranging between thirty degrees and eighty degrees with respect to an axis that is perpendicular to the first surface.5. The device as recited in claim 2 , wherein:the tissue capture device defines a receiving portion;the plurality ...

METHOD AND APPARATUS FOR MONITORING STATE OF INFLAMMATORY BOWEL DISEASE

An example of a system for monitoring and treating a medical condition of a patient may include signal inputs to receive patient condition signals indicative of a state of inflammatory bowel disease (IBD), a signal processing circuit configured to process the patient condition signals and generate patient condition parameters indicative of the state of IBD using the processed patient condition signals, and a medical condition analyzer configured to analyze the patient condition parameters and determine the medical condition including the state of IBD using an outcome of the analysis. The patient condition parameters may include one or more physiological marker parameters each representative of a physiological marker of IBD and one or more quality of life parameters each being measure of quality of life of the patient. 1. A system for monitoring and treating a medical condition of a patient , comprising:signal inputs configured to receive patient condition signals indicative of a state of inflammatory bowel disease (IBD);a signal processing circuit configured to process the received patient condition signals and to generate patient condition parameters using the processed patient condition signals, the patient condition parameters indicative of the state of IBD; and a physiological marker input configured to receive one or more physiological marker parameters of the patient condition parameters, the one or more physiological marker parameters each representative of a physiological marker of IBD;', 'a quality of life input to receive one or more quality of life parameters of the patient condition parameters, the one or more quality of life parameters each being a measure of quality of life of the patient; and', 'a parameter analysis circuit configured to analyze the received patient condition parameters and determine the medical condition including the state of IBD using an outcome of the analysis., 'a medical condition analyzer configured to determine the medical ...

SYSTEM AND METHOD FOR AUTOMATIC PERFUSION MEASUREMENT

A system and a method for automatically and continuously measuring and assessing hemodynamics uses fluorescence imaging in which the fluorescent agent is controlled and automated. A method of automatic perfusion assessment of an anatomical structure of a subject includes administration into a vein of a bolus corresponding to less than 0.01 mg ICG/kg body weight of a first fluorescence imaging agent. A system for automatic perfusion assessment during a medical procedure includes a controllable injection pump for holding at least one first fluorescence imaging agent, the injection pump being configured for injecting a predefined amount of the first fluorescence imaging agent into the blood. The system is configured for receiving and analysing a time series of fluorescence images and determining at least one perfusion parameter based on the analysis. 1. A method of automatic perfusion assessment of a tissue of an anatomical structure of a subject , the method comprising:administering a first fluorescence imaging agent having an emission maximum into a vein of the subject as a first bolus, the first bolus comprising an amount of the first fluorescence imaging agent corresponding to less than 0.01 mg ICG/kg body weight of the subject;acquiring and analysing a time series of fluorescence images of the tissue of said anatomical structure following administering the first bolus of the first fluorescence imaging agent, producing an analysis; anddetermining at least one perfusion parameter of said anatomical structure based on said analysis.2. The method of claim 1 , wherein administering the first fluorescence imaging agent comprises injection by a controllable injection pump.3. The method of claim 1 , wherein administering the first fluorescence imaging agent further comprises injection of a series of subsequent boluses with a predefined time between subsequent boluses.4. The method of claim 1 , wherein administering the first fluorescence imaging agent comprises injection ...

System that assesses health condition by measuring pulse and method of assessing the same

A system that assesses health condition by measuring pulse includes: a pulse measuring device that measures an artery of a user who receives assessment of health condition; a terminal that has a function that transmits measured-value data on pulse measured by the pulse measuring device to a health assessing administrator and receives information from the health assessing administrator; an administrative server that is administered by the health assessing administrator, analyzes the measured-value data transmitted from the terminal, and stores various data on health condition that is necessary to assess and analyze health condition. The user transmits the measured-value data on measured pulse from the terminal to the health assessing administrator, and the health assessing administrator transmits assessment information on health condition analyzed by the administrative server to the terminal.

METHODS AND ARTICLES FOR DELIVERING VIABLE CELLS INTO SOLID TISSUE

Embodiments provide swallowable devices, preparations and methods for delivering viable cells (VC) into the GI tract including GI wall tissue or other tissue site. Particular embodiments provide a swallowable device such as a capsule for delivering VC into an intestinal wall or other site. The VC can be contained within a tissue-penetrating shell disposed in the capsule that protects the VC as they pass through the GI tract until they are inserted into GI tract tissue or other location. The shell desirably has shape, size and material consistency to be contained in a swallowable capsule, delivered from the capsule into solid tissue by the application of force on the shell and biodegrade within the solid tissue to release the VC into the tissue. Within the shell or other structure the VC can be maintained in a viability-sustaining gel that preserves the viability of the VC for selected time periods. 1. A method for orally delivering viable cells to intestinal tissue of a patient , the method comprising:swallowing a drug delivery device containing a tissue penetrating article which contains a mass of viable cells, wherein the article passes through the gastrointestinal tract with the article intact and the cells remaining viable; andreleasing the article from the drug delivery device in response to a condition in the intestine, wherein the article penetrates into the intestinal tissue by the application of a propulsive force onto the article to release the cells or substances produced by the cells into the intestinal tissue.2. The method of claim 1 , wherein the intestinal tissue is intestinal wall tissue claim 1 , small intestine wall tissue or peritoneal wall tissue.3. The method of claim 1 , wherein the delivered cells reseed a portion of the mucosa or lining of the small intestine claim 1 , large intestine claim 1 , or stomach.4. The method of claim 1 , wherein the condition is a pH or a pH in the small intestine.5. The method of claim 2 , wherein the pH in the ...

METHODS FOR OPTIMIZING THE TIMING OF FOOD INGESTION THROUGH MONITORING OF ACOUSTICAL ACTIVITY OF THE ABDOMINAL REGION

Described herein are methods and systems for monitoring acoustical activity from the abdominal region to guide the optimal timing of food ingestion. According to one embodiment of the method, the rate of intestinal digestion events, as well as the change in the rate across specific time periods, is analyzed to guide ingestion behavior in a way that improves health. The result of guidance may be to reduce weight in people who are obese, to improve performance in athletes seeking to balance energy availability and energy expenditure, or to increase caloric intake in people who are undernourished. The method can be applied using a smartphone application to provide contextually appropriate and specific user guidance about whether, when, and how much to eat in a manner that aligns with the physiologic patterns of intestinal activity. 1. A method for optimizing timing of food ingestion by a user , the method comprising:receiving acoustic data from one or more sensors, each of the one or more sensors being in contact with the user and configured to capture acoustic data from an abdominal region of the user;analyzing, via at least one processor, the acoustic data to determine a value of one or more digestive metrics;determining an optimal action related to food ingestion based on at least one of the one or more digestive metrics; anddisplaying, via a display device communicatively coupled to the at least one processor, information indicative of the optimal action related to food ingestion.2. The method of claim 1 , wherein one of the one or more digestive metrics comprises a measure of a current intestinal rate or a running average of an intestinal rate.3. The method of claim 2 , wherein the measure of the current intestinal rate comprises a number of digestion events experienced during a time period of one minute.4. (canceled)5. The method of claim 2 , wherein the running average of the intestinal rate is based on acoustic data analyzed during a time period of twenty ...

BIOLOGICAL INFORMATION MEASUREMENT SYSTEM

The biological information measurement system of the present invention includes a test subject-side device provided in a toilet installation room, and a server communicable with the test subject-side device, the test subject-side device includes a sulfur-containing gas sensor sensitive to sulfur-containing gas and outputting detection data, a transmitter-receiver transmitting measurement data including detection data of the sulfur-containing gas detected by the sulfur-containing gas sensor to the server, and the server includes a database in which measurement data including detection data of sulfur-containing gas detected by the sulfur-containing gas sensor is accumulated and recorded with dates and times of defecation acts by being associated with test subject identification information, and server-side data analyzer that analyzes physical condition of a test subject on the basis of a time-dependent variation tendency of the measurement data accumulated and recorded in the database. 1. A biological information measurement system that diagnoses risk of illness of a test subject based on defecation gas discharged in to a bowl of a flush toilet , the biological information measurement system comprising:a test subject identification device that accepts an input of a test subject identification information;a suction device that sucks gas in the bowl into which the defecation gas is discharged by the test subject;a gas detector provided for exposure to the gases sucked by the suction device, the gas detector comprising a first gas sensor configured to detect an odiferous gas composed of a sulfur component and a second gas sensor configured to detect a healthy-state gas composed of at least one of hydrogen gas, carbon dioxide gas or methane gas, wherein the first gas sensor is configured to output a first detection data, and the second gas sensor is configured to output a second detection data;a control device that controls the suction device and the gas detector;a ...

SYSTEM AND METHOD FOR ASSESSING PERFUSION IN AN ANATOMICAL STRUCTURE

A system is provided for measuring and assessing hemodynamics in an anatomical structure of a subject, along with a method for image processing hemodynamics in at least a part of an anatomical structure in video images acquired from a subject. The system and method relates to measuring and assessing hemodynamics in, around and near the surface, in particular the gastrointestinal wall, of the gastrointestinal tract of a subject. A method for image processing hemodynamics in at least a part of an anatomical structure in video images acquired from a subjectmay may performing image analysis of at least one video sequence acquired after a fluorescent contrast agent has been supplied to the subject, calculating intensity values in one or more regions of interest based on the image analysis, and determining the perfusion slope of the flow of the fluorescent contrast agent through at least one of said regions of interest. 1. A method for assessing hemodynamics in at least a first part of the gastrointestinal tract in video images acquired from a subject , the method comprising the steps of:supplying a fluorescent contrast agent to the subject,acquiring at least one first video sequence of at least said first part of the gastrointestinal tract after said fluorescent contrast agent has been supplied to the subject, calculating intensity values in at least one region of interest selected in the analysed video sequence, and', 'determining the perfusion slope of the flow of the fluorescent contrast agent through at least one of said regions of interest,, 'performing image analysis of at least a part of said first video sequence thereby'}wherein the perfusion slope is defined by the slope of said intensity values from a slope start to a slope end, and wherein the perfusion slope is determined from a histogram in a parameter space binning all slope values calculated after said slope start and where the perfusion slope is defined as the most frequent value of the histogram.2. The ...

Systems and Methods for an Actively Controlled Optical Imaging Device

Systems and methods for a tethered optical imaging probe configured to be integrated into an optical system for medical diagnosis are provided. In one configuration, the present disclosure provides a tethered optical imaging probe including a motor arranged within a swallowable capsule. A rotational speed of the motor is actively controlled by a feedback signal.

ORGAN IMAGING DEVICE

An organ image capturing device includes an imaging unit to image a tongue of a living body, and a computing unit. The computing unit calculates a numerical value indicating a state of at least one of a plurality of indices pertaining to health by way of computations using chromaticity values that are obtained from captured image data of the tongue acquired by the imaging unit. 1. An organ imaging device comprising:an imager which images a tongue of a living body; anda processor which calculates a numerical value indicating condition regarding at least one of a plurality of healthiness indices by using a chromaticity value obtained from data of a taken image of the tongue acquired by the imager, and outputs the numerical value.2. The organ imaging device according to claim 1 , wherein the chromaticity value is a value obtained in any of three upper claim 1 , center claim 1 , and lower regions in a center part of the taken image of the tongue in a left/right direction that corresponds to each of the indices.3. The organ imaging device according to claim 2 , wherein the chromaticity value is proportion of red image data claim 2 , proportion of green image data claim 2 , or proportion of blue image data with respect to reference data including at least any of the red image data claim 2 , the green image data claim 2 , and the blue image data claim 2 , and the chromaticity value is a value other than 1.4. The organ imaging device according to claim 3 , wherein:the chromaticity value is proportion of blue image data with respect to the reference data in the upper region of the taken image of the tongue; andthe processor calculates a numerical value of a systolic or diastolic blood pressure as one of the indices by calculation using the proportion.5. The organ imaging device according to claim 3 , wherein:the chromaticity value is proportion of red image data with respect to the reference data in the upper region of the taken image of the tongue; andthe processor ...