22-08-2013 дата публикации
Номер: US20130216498A1
Принадлежит:
New imidazopyridine derivatives having the chemical structure of formula (I) are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK). 2. The method according to claim 1 , wherein{'sub': 1', '2', '3', '4', '9', '1', '6', '2', '4', '2', '4', '1', '4', '1', '4', '3', '10', '3', '10', '5', '14', '5', '9, 'R, R, R, Rand Rare each independently chosen from a hydrogen atom, halogen atoms, cyano, linear or branched C-Calkyl, C-Calkenyl, C-Calkynyl, C-Chaloalkyl, C-Chydroxyalkyl, C-Ccycloalkyl, C-Ccycloalkenyl, monocyclic or polycyclic C-Caryl, 5- to 14-membered heteroaryl containing at least one heteroatom selected from O, S and N, 5- to 14-membered heterocyclyl containing at least one heteroatom selected from O, S and N, bicyclyl containing monocyclic C-Caryl or heteroaryl bonded directly to a 5- to 9-membered cycloalkyl or heterocyclyl, said heteroaryl or heterocyclyl containing at least one heteroatom selected from O, S and N, an aza-bicycloalkyl having up to 12 carbon atoms and an aza-bicycloalkenyl having up to 12 carbon atoms,'}wherein the alkenyl, alkynyl, haloalkyl, hydroxyalkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl, bicyclyl, aza-bicycloalkyl and aza-bicycloalkenyl are independently unsubstituted or substituted by one or more Ra, and the alkyl groups are independently unsubstituted or substituted with one or more Rb;{'sub': 1', '2', '3', '4', '9', '13', '13', '2', '13', '2', '13', '14', '13', '2', '14', '13', '2', '14', '13', '13', '13', '2', 'n', '13', '13', '14', '2', 'n', '13', '14', '13', '2', 'n', '14', '13', '2', 'n', '14', '15, 'or R, R, R, Rand Rare each independently chosen from —SR, —SOR, —S(O)R—S(O)NRR, —NRS(O)R, —NRS(O)NR, —OR, —C(O)OR, —O—C(O)R, —C(O)—(CH)—R, —NRR, —C(O)—(CH)—NRR, —NRC(O)—(CH)—Rand —NRC(O)—(CH)—NRR, wherein each n is independently 0, 1 or 2;'}{'sub': 9', '9', '5', '12', '1', '6', '5', '14', '1', '6', '1', '4, ' ...
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