Kassette mit einem Sensor zur Bestimmung der Differenz eines ersten und eines zweiten Flüssigkeitsstroms

Die Erfindung bezieht sich auf das Bilanzieren von Flüssigkeitsströmen in einem Dialysesystem. Insbesondere bezieht sich die Erfindung auf eine Kassette zum Fördern eines ersten und eines zweiten Flüssigkeitsstroms in einem Dialysesystem, wobei der erste und der zweite Flüssigkeitsstrom medizinische Flüssigkeitsströme wie beispielsweise Dialysatströme oder Blutströme sein können, wobei die Kassette einen Sensor als Vorrichtung zur Bilanzierung des ersten und des zweiten Flüssigkeitsstroms aufweist und wobei der Sensor einen ersten Kanal für den ersten Flüssigkeitsstrom und einen zweiten Kanal für den zweiten Flüssigkeitsstrom aufweist. Ferner bezieht sich die Erfindung auf eine Dialysevorrichtung, die ausgestaltet ist, zumindest eine Kassette aufzunehmen, die wie oben dargelegt ausgestaltet ist. Des Weiteren bezieht sich die vorliegende Erfindung auf eine Anordnung, durch die zwei Kanäle für den ersten und den zweiten Flüssigkeitsstrom ausgebildet werden. Zusätzlich bezieht sich die Erfindung ...

Control system

A control system is provided for controlling blood gas values in blood processed by an oxygenator. The oxygenator generates arterial blood by exposing venous blood to oxygen from an oxygenation gas supply. A monitoring arrangement determines the blood gas values in the arterial blood and a controller responsive to the monitoring arrangement controls parameters of the oxygenation gas supplied to the oxygenator. This allows the blood gas values to be adjusted toward a pre-determined level. The oxygen supply may be altered via the flow rate or gas composition. The monitoring arrangement may continuously monitor the blood using non-contact methods. It may monitor the oxygen and carbon dioxide in the inlet gases, exhaust gases, and venous and arterial blood, in order to calculate the oxygen uptake and hence an expected blood gas level; it may also calculate a difference between the expected and actual blood gas levels and thus apply an offset to the change in gas supply to take into account ...

Flow balancing devices, methods, and systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

HEMODIALYSIS SYSTEMS

H�MOFILTRATIONSSYSTEM

HÄMOFILTRATIONSSYSTEM.

Automatic detection and adjustment of a pressure pod diaphragm

A system for controlling the position of a diaphragm in a diaphragm-containing pressure pod, is provided. The system can include a peristaltic pump, a pressure pod having a flow- through fluid side and a gas side that are separated by a diaphragm, and a pressure sensor operatively connected to the gas side. The pressure sensor is configured to sense pulses of pressure resulting from movement of the diaphragm and caused by the action of the peristaltic pump. A gas source and a valve can be in fluid communication with the gas side of the pressure pod and can be configured to provide gas to, or vent gas from, the gas side. A controller receives pressure signals from the pressure sensor and controls the valve in response, and in so doing, controls the position of the diaphragm. Methods for positioning the diaphragm are also included.

BLOOD PRESSURE ALARM SYSTEM FOR DIALYSIS MACHINE

There is disclosed herein a blood pressure alarm system for use in a dialysis machine whereby alarms may be activated, and a blood pump deactivated if the actual blood pressure increases above or decreases below predetermined levels. The levels are determined by setting a particular blood pressure point and setting the amount by which the pressure can vary above and below the set point; the range of variation is sometimes referred to as the alarm window. A digital memory is provided for storing the set point and preventing variation of the set point with time.

CALCULATION OF THE PATIENT FLUID REMOVAL RATE TO COMPENSATE FOR THE VOLUME OF FLUID NOT REMOVED BECAUSE OF MACHINE DOWN TIMES

A patient fluid removal compensation volume may be determined to make up for the patient fluid removal that does not occur during machine down times, and the patient fluid removal rate may be increased until the compensating volume is satisfied.

BLOOD DIALYZER

A hemodialysis apparatus that carries out hemodialysis treatment by measuring or calculating the blood volume or its volume change as a blood indication level, and by controlling dialysis conditions according to said target blood indication level, wherein the chronological course of said blood indication level is defined as a target control line, and the primary blood volume (BV0) can be calculated as blood indication level. In the former part of the dialysis operation, the water removal is controlled so that the circulating blood volume in the body approach to the standard blood volume (BV st) with the use of said target control line. After the water removal of the former part of the dialysis operation, when the circulating blood volume in the body attains the standard blood volume (BV st), the latter part of the dialysis operation is started. In said latter part of the dialysis operation, the water removal operation is performed by substantively maintaining said standard blood volume ...

Measuring the pressure in the extracorporeal circulation method

Extracorporeal blood treatment device and its control method

BLOOD PUMP CONTROLLER

Sistema de gestión de información relacionada con las diferencias entre los individuos en el tratamiento por dialisis.

PROPORCIONAR UN SISTEMA DE HEMODIÁLISIS OPTIMIZADO CAPAZ DE SUPRIMIR LAS VARIACIONES EN UNA PRESIÓN ARTERIAL DE ACUERDO CON LA DIFERENCIA INDIVIDUAL DE UN PACIENTE. EL SISTEMA ESTÁ CONFIGURADO PARA INCLUIR: MEDIOS DE ADQUISICIÓN DE INFORMACIÓN RELACIONADA CON LA SANGRE CONFIGURADOS PARA ADQUIRIR INFORMACIÓN DE FLUJO SANGUÍNEO DE INFORMACIÓN BIOLÓGICA DEL PACIENTE EN UN CIRCUITO SANGUÍNEO PARA HEMODIÁLISIS, LA INFORMACIÓN BIOLÓGICA DEL PACIENTE SIENDO INFORMACIÓN DE RESISTENCIA VASCULAR PERIFÉRICA, INFORMACIÓN DE PRESIÓN ARTERIAL, INFORMACIÓN FACIAL, INFORMACIÓN DE MOVIMIENTO CORPORAL, INFORMACIÓN DE TEMPERATURA, E INFORMACIÓN DE HUMEDAD Y SIMILARES; MEDIOS DE GESTIÓN DE INFORMACIÓN DE DIFERENCIA INDIVIDUAL CONFIGURADOS PARA ADQUIRIR Y GESTIONAR LA INFORMACIÓN DE DIFERENCIA INDIVIDUAL DEL PACIENTE A PARTIR DE LA INFORMACIÓN RELACIONADA CON LA SANGRE; Y MEDIOS DE DIÁLISIS OPTIMIZADOS CONFIGURADOS PARA REALIZAR TRATAMIENTO DE DIÁLISIS OPTIMIZADO PARA LOS PACIENTES SOBRE LA BASE DE LA INFORMACIÓN ...

INDIVIDUAL DIFFERENCE INFORMATION MANAGEMENT SYSTEM IN DIALYSIS TREATMENT

The system is configured to include: blood related information acquiring means configured to acquire blood flow information and patient biological information in a blood circuit for hemodialysis, the patient biological information being peripheral vascular resistance information, blood pressure information, face information, body movement information, temperature information, and humidity information and the like; individual difference information managing means configured to acquire and manage patient individual difference information from the blood related information; and optimized dialysis means configured to perform optimized dialysis treatment for the patients on the basis of the patient individual difference information.

Cassette with a sensor for determining the difference between a first and a second fluid stream

The invention relates to the balancing of fluid streams in a dialysis system. In particular the invention relates to a cassette for conveying a first and a second fluid stream in a dialysis system, wherein the first and the second fluid streams can be medical fluid streams such as for example dialysate streams or blood streams, wherein the cassette has a sensor as a device for balancing the first and the second fluid stream, and wherein the sensor has a first channel for the first fluid stream and a second channel for the second fluid stream. The invention further relates to a dialysis system, which is configured to accommodate at least one cassette which is configured as described above. Furthermore, the present invention relates to an arrangement by which two channels for the first and the second fluid streams are formed. In addition, the invention relates to a method for construction of the two channels or the arrangement.

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

In an apparatus for extracorporeal blood treatment, an extracorporeal circuit (6) is connected to a blood chamber (3) of a membrane device (2). A pump (10) displaces a priming fluid from a source of a priming fluid (9) to a drainage (11) for discharging the priming fluid. A control unit (13) is provided with a processor which controls the pump at a preset first flow rate value, and receives from a pressure sensor (12) a first pressure value, compares the first pressure value with a reference pressure value and, on the basis of this comparison, determines whether or not the extracorporeal circuit is of a pediatric type or of an adult type. The invention is particularly useful during a stage of readying a dialysis apparatus.

Verfahren und Vorrichtung zur ereignisabhängigen Grenzwertüberwachung einer Dialysemaschine

Die Erfindung betrifft ein Verfahren zur ereignisgesteuerten Grenzwertsetzung im Rahmen einer Überwachung einer Dialysemaschine (110) auf Einhaltung von Grenzwerten. Bei dem Verfahren wird eine Vielzahl von grenzwertrelevanten Ereignissen vorbestimmt (1000), die bei der Geräteüberwachung zu berücksichtigen sind und die jeweils als Zustandsvariable in einem Zustandsvektor gespeichert werden. Des Weiteren werden Referenz-Zustandsvektoren (R-ZV) vorbestimmt (2000), denen jeweils eine Ziel-Grenzwerteinstellung (Z-GW) zugeordnet ist. In einer Überwachungsphase werden dann Messsignale (z. B. aktuelle gefördertes Blutvolumen, Druck im venösen Zweig etc.) für die Zustandsvariablen zur Berechnung eines Messsignalvektors erfasst (3000). Daraufhin wird der berechnete Messsignalvektor mit dem vorbestimmten Referenz-Zustandsvektor (R-ZV) verglichen (4000) und bei Übereinstimmung wird die Dialysemaschine (110) gesteuert (6000), indem sie mit den Ziel-Grenzwerten (Z-GW) überwacht wird (7000). Die Dialysemaschine ...

Hämodialysegerät mit automatischer Einstellung des Dialysierflüssigkeitsflusses.

Apparatus for controlling fluid flow in a circuit

SYSTEM FOR THE OPTIMIZATION OF THE HINUND OF RETURN FLOW WITH APHERESE

APPARATUS FOR THE MONITORING OF AN ENTRANCE WITH ELECTRODES FROM CONDUCTIVE POLYMER MATERIALS

BLUTDIALYSATOR

Hemofiltration system

MONITORING OF PHYSIOLOGICAL PARAMETERS

External functional device, blood treatment apparatus for accommodating such an external functional device, and methods

An external functional device is disclosed, comprising at least one housing element, at least one chamber (9, 15, 21, 57) that is integrated into the housing element and holds medical fluids, at least one duct (17, 19, 49) that is integrated into the housing element and holds and/or conducts a medical fluid, and at least one valve mechanism (35, 36, 39, 40, 47, 51, 53, 61) that is entirely or partly integrated into the housing element and controls or regulates a fluid flowing through the external functional device. The invention further relates to a blood treatment apparatus and methods that can be carried out using the external functional device or blood treatment device of the invention.

An apparatus and a method of controlling an extracorporeal blood treatment

An apparatus is described for extracorporeal blood treatment (1), comprising a treatment unit (2), an extracorporeal blood circuit (8) and a fluid evacuation line (10). The apparatus comprises a control unit (21) connected with a pressure sensor (13, 14) and with a blood pump (9) and configured to move the blood pump (9), generating a variable flow (Q(t)) with a constant component (Q ...

An apparatus and a method of controlling an extracorporeal blood treatment

An apparatus is described for extracorporeal blood treatment (1), comprising a treatment unit (2), an extracorporeal blood circuit (8) and a fluid evacuation line (10). The apparatus comprises a control unit (21) connected with a pressure sensor (13, 14) and with a blood pump (9) and configured to move the blood pump (9), generating a variable flow (Q(t)) with a constant component (Q ...

SYSTEMS AND METHODS FOR OPTIMIZATION OF PLASMA COLLECTION VOLUMES

A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.

EXTERNAL FUNCTIONAL DEVICE, BLOOD TREATMENT APPARATUS FOR ACCOMMODATING SUCH EXTERNAL FUNCTIONAL DEVICE, AND METHODS

An external functional means is proposed which comprises at least one housing body, at least one chamber (9, 15, 21, 57) integrated into the housing body for receiving medical fluids, at least one passage (17, 19, 49) integrated into the housing body for receiving and/or conducting a medical fluid, and at least one valve means (35, 36, 39, 40, 47, 51, 53, 61) completely or partly integrated into the housing body for controlling or regulating a fluid flowing through the external functional means. The invention further specifies a blood treatment apparatus and methods which may be carried out by means of the external functional means of the invention and by means of the blood treatment apparatus, respectively.

A METHOD FOR ASSESSING A PATIENT'S FLUID STATUS AND/OR SENSITIVITY TO FLUID REMOVAL, CONTROLLER, AND DEVICES

The present invention relates to a method for assessing a patient's sensitivity to fluid removal from his vascular system or to fluid replacement or addition regarding to his hydration state, the method comprising the step of determining a value reflecting the distribution of fluid between at least two distribution spaces of the body of the patient or changes thereof from measured or calculated values, and assessing whether the value fulfils at least one criterion. It also relates to a controller, an apparatus, a device, a digital storage means, a computer program product, and a computer program.

AUTOMATIC DETECTION AND ADJUSTMENT OF A PRESSURE POD DIAPHRAGM

A system for controlling the position of a diaphragm in a diaphragm-containing pressure pod, is provided. The system can include a peristaltic pump, a pressure pod having a flow- through fluid side and a gas side that are separated by a diaphragm, and a pressure sensor operatively connected to the gas side. The pressure sensor is configured to sense pulses of pressure resulting from movement of the diaphragm and caused by the action of the peristaltic pump. A gas source and a valve can be in fluid communication with the gas side of the pressure pod and can be configured to provide gas to, or vent gas from, the gas side. A controller receives pressure signals from the pressure sensor and controls the valve in response, and in so doing, controls the position of the diaphragm. Methods for positioning the diaphragm are also included.

AN APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT.

It is disclosed an apparatus for extracorporeal blood treatment (1) having a control unit (15) connected to an ultrafiltration device (20) and to a fluid preparation section (30) of fresh dialysis liquid. The control unit (15) is configured to receive measured values of the change of blood volume, the amount of ultrafiltration volume, and conductivity or to the concentration for at least one substance in the blood (BV%mes(t); UFmes(t), WLmes(t); Cbmes(t)); the control unit (15) is also configured to receive prescription values for the same parameters and to control ultrafiltration and adjust conductivity in the fresh dialysis liquid based on the difference between said measured values and said prescription values.

BLOOD COLLECTION SYSTEM AND METHOD

A blood collection system comprises a suction unit (11), a hose arrangement(12) connectedto the suction unit, means for aspirating blood and air through the suction unit and for pumping said blood and air through the hose arrangement, a flow sensing unit (14) for continuously sensing the blood flow through the hose arrangement, an anticoagulant additive dosing system (15) for continuously dosing an anticoagulant additive into the blood flowed through the hose arrangement in response to the continuously sensed blood flow, a mixing unit (16) for mixing the blood with the anticoagulant additive dosed into the blood, and a collection vessel (17) for collecting the mixed blood and anticoagulant additive. The means for aspirating and pumping the blood and air is a pump system (13) providing a known constant volume flow of the blood and air in the hose arrangement, the flow sensing unit (14) is arranged for continuously sensing the mass flow of blood through the hose arrangement by means of continuously ...

METHOD FOR EVALUATING LIQUID STNOGO STATUS OF A PATIENT AND/OR SENSITIVITY TO REMOVAL OF LIQUID STI, CONTROLLER AND DEVICE

Method for determining the pressure in extracorporeal circuit

With the diversity of the user interface of the dialysis apparatus and method

Apparatus and method for determining residual blood in a dialysis machine Dialysis system

A METHOD FOR ASSESSING A PATIENT'S FLUID STATUS AND/OR SENSITIVITY TO FLUID REMOVAL, CONTROLLER, AND DEVICES

DEVICE FOR REGULATING AT LEAST ONE FILTRATION VALUE, HAEMODIALYSIS MACHINE AND CORRESPONDING METHOD AND USE

The invention relates to a device for regulating at least one filtration value in a machine for treating a medical liquid, in particular a blood treatment machine, having at least one centrifugal pump means, to a haemodialysis machine and to a corresponding method and use.

Network communication and message protocol for a medical perfusion system

A network communication and messaging protocol for use in a medical perfusion system, provides the rules which govern how, among other things, information and data is conveyed between the various devices which are connect to the network. The rules define the different types of messages that are used in conveying information and data, as well as the formatting for each of those message types. The various messages provide the ability to configure the perfusion system devices, establish links between the perfusion system devices, and convey various types of information and data, even when the main network controller is unavailable.

Method as well as apparatuses for testing at least one function of a medical functional device

The invention relates to a method for testing at least one function of a medical functional device which is inserted in and connected and compressed with a medical treatment apparatus, and/or a function of this treatment apparatus, wherein between a hydraulic device or a pneumatic unit of the treatment apparatus and the functional device at least one fluid communication is established. It further relates to a detection device which is programmed and/or configured for executing the method according to the invention as well as a medical treatment apparatus which comprises at least one detection device and/or is in signal transmission or is connected for signal transmission with it, a digital storage medium, a computer program product as well as a computer program.

BLOOD PURIFICATION DEVICE

A blood purification device includes a blood circuit for extracorporeally circulating blood of a patient; a liquid supply circuit for supplying a supply liquid to the blood circuit or to a blood purifier provided on the blood circuit and a waste liquid circuit for discharging the waste liquid from the blood purifier. Each of the blood circuit, the liquid supply circuit and the waste liquid circuit comprises a flexible tube. The blood purification device comprises a tube identification unit that performs a tube identification process for identifying a tube used for the blood circuit, the liquid supply circuit or the waste liquid circuit or determining whether or not there is an abnormality in the tube, based on an amount of liquid sent from a peristaltic pump provided on the blood circuit, the liquid supply circuit or the waste liquid circuit, or pressure fluctuation in the circuit, caused when driving the pump for a predetermined time.

BLOOD PRESSURE ALARM SYSTEM FOR DIALYSIS MACHINE

CONTROLLING MEAN IN A EXTRAKORPORALEN BLUTKREISLAUF

H�MOFILTRATIONSSYSTEM

TECHNOLOGY FOR EXTRAKORPORALE BLOOD TREATMENT

EQUIPMENT FOR THE EXTRAKORPORALE BLOOD TREATMENT

DIALYSIS EQUIPMENT WITH BLOOD PRESSURE MONITORING BY MEASUREMENT OF THE OXYGEN SATURATION OF THE BLOOD AND THE SALT CONCENTRATION

Network communication and message protocol for a medical perfusion system

Method and system for detecting or verifying a blood circuit connected to an extracorporeal blood treatment console

A method to determine a type of blood circuit attached to an extracorporeal blood treatment console including: pumping a liquid through a blood passage of the blood circuit, sensing a first pressure in: the blood passage while the passage is closed and pumping stopped, pumping an additional amount of the liquid into the blood passage while the blood passage is and remains closed and thereafter sensing a second pressure, and determine a dimensional characteristic of a fluid passage in the blood passage based on the additional amount of the liquid and the second pressure.

Hemofiltration system

Method in dialysis and dialyzer for working the method

Apparatus comprising device for determining an especially geometrical property of the apparatus

The present invention relates to an especially medical apparatus (200) comprising at least one hard unit (201) having fluid lines (202) conducting an especially medical fluid, especially blood, through the hard unit (201); a converter (205, 207, 209, 211), said converter (205, 207, 209, 211) being arranged for measuring a property (Q) of the fluid while the latter is present in one of the fluid lines (202); and a device for determining an especially geometrical property (dx, dy) of the apparatus (200), especially of a fluid line (202).

Calculation of the patient fluid removal rate to compensate for the volume of fluid not removed because of machine down times

A patient fluid removal compensation volume may be determined to make up for the patient fluid removal that does not occur during machine down times, and the patient fluid removal rate may be increased until the compensating volume is satisfied.

Systems and methods for optimization of plasma collection volumes

A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.

A DEVICE INCLUDING A DEVICE FOR DETERMINING A, PARTICULARLY GEOMETRIC, CHARACTERISTIC OF THE DEVICE

The present invention relates to an especially medical apparatus (200) comprising at least one hard unit (201) having fluid lines (202) conducting an especially medical fluid, especially blood, through the hard unit (201); a converter (205, 207, 209, 211), said converter (205, 207, 209, 211) being arranged for measuring a property (Q) of the fluid while the latter is present in one of the fluid lines (202); and a device for determining an especially geometrical property (dx, dy) of the apparatus (200), especially of a fluid line (202).

AUTOMATED APPARATUS FOR MONITORING OF PHYSIOLOGICAL PARAMETERS AND CONTROL OF FLUID THERAPY INCLUDING EXTRACORPOREAL ULATION OF BLOOD

EXTERNAL FUNCTIONAL MEANS, BLOOD TREATMENT APPARATUS FOR ACCOMMODATING SUCH EXTERNAL FUNCTIONAL MEANS, AND METHOD

APPARATUS FOR AN EXTRACORPOREAL BLOOD TREATMENT

The invention relates to a device for an extracorporeal blood treatment, comprising an extracorporeal blood circuit in which a dialyzer is arranged and comprising a dialysate circuit. The blood circuit is fluidically connected to a first chamber, and the dialysate circuit is fluidically connected to a second chamber of the dialyzer. The two chambers are separated by a semipermeable membrane, and a dialysate pump is provided in the dialysate circuit in order to pump the dialysis solution. The device has a control unit which is designed to operate the device in a first phase and a second phase which follows the first phase, and the dialysate pump is operated with a lower flow rate in the first phase than in the second phase and/or the dialysate pump pumps a dialysis solution with a higher concentration, with respect to at least one component, in the first phase than in the second phase.

AUTOMATIC DETECTION AND ADJUSTMENT OF A PRESSURE POD DIAPHRAGM

A system for controlling the position of a diaphragm in a diaphragm-containing pressure pod, is provided. The system can include a peristaltic pump, a pressure pod having a flow- through fluid side and a gas side that are separated by a diaphragm, and a pressure sensor operatively connected to the gas side. The pressure sensor is configured to sense pulses of pressure resulting from movement of the diaphragm and caused by the action of the peristaltic pump. A gas source and a valve can be in fluid communication with the gas side of the pressure pod and can be configured to provide gas to, or vent gas from, the gas side. A controller receives pressure signals from the pressure sensor and controls the valve in response, and in so doing, controls the position of the diaphragm. Methods for positioning the diaphragm are also included.

APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD AND PROCESS OF CALCULATING SET FLOW RATES IN A MEDICAL APPARATUS FOR DELIVERY OR COLLECTION OF FLUIDS

An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit (10) is configured calculate set values of two or more of the fluid flow rates based on a fluid flow rate set by the operator and on a prescribed dose value (Dset).

TECHNIQUE FOR EXTRACORPOREAL TREATMENT OF BLOOD

The apparatus automatically performs and monitors the extracorporeal treatment of the blood of a patient by any selected one of a plurality of predetermined treatments. Each of the treatments involves the flow of blood from the patient into a primary chamber (44) of a filtration unit (40), past a semipermeable membrane (42) located in the filtration unit (40) which separates the primary chamber (44) from a secondary chamber (46) of the filtration unit (40), out the filtration unit and back to the patient. A replacement fluid is selectively and controllably added to the blood, as required for the selected treatment. A secondary fluid is controllably and selectively introduced into the secondary chamber (46) of the filtration unit (40) for controllably collecting material passing across the semipermeable membrane (42) from the blood or for supplying material to pass across the semipermeable membrane (42) into the blood as required for the selected treatment. Materials are removed from the ...

AUTOMATIC APPARATUS FOR BLOOD DIALYIS AND PRIMING METHOD USING THE APPARATUS

Blood purifying device

BLOOD TREATMENT DEVICE AND METHOD FOR ADJUSTING THE OPERATING PARAMETERS OF A BLOOD TREATMENT DEVICE

The present invention relates to a blood treatment device, in particular a dialysis machine, having at least one adjustment means with which the blood pump delivery rate can be adjusted, and having detection means for detecting at least two physical properties, wherein each of these is a physical property of a patient who is to be treated using the blood treatment device, and wherein the blood treatment device is designed in such a way that the blood pump delivery rate can be adjusted and/or limited with the aid of the adjustment means on the basis of the at least two physical properties detected. The present invention further relates to a method for adjusting the operating parameters of a blood treatment device.

Enhanced clearance in an artificial kidney incorporating a pulsatile pump

A continuous renal replacement therapy (CRRT) device is provided that weighs between 2 and 10 pounds. The CRRT device can be portable, mobile or completely worn on the person of the patient. Blood and dialysate are each pumped in a pulsed or pulsatile manner through a dialyzer such that a significant portion of the peak pulse of the blood flow coincides with a significant portion of a low pulse portion of the dialysate flow. An differential pressure between a dialysate inlet of the dialyzer and the blood inlet of the dialyzer periodically changes from a high differential pressure of between 70 and 120 mmHg for a first time period and a low differential pressure of between −10 and 10 mmHg for a first time period and a low differential pressure of between −10 and 10 mmHg for a second time period. The frequency of the high and low differential pressure cycle is between about 0.5 and 4 Hz.

HEMOFILTRATION SYSTEM AND METHOD BASED ON MONITORED PATIENT PARAMETERS

A multipurpose hemofiltration system and method are disclosed for the removal of fluid and/or soluble waste from the blood of a patient. The system and method are equally applicable to adult, pediatric and neonatal patients. In one embodiment, the system continuously monitors the weight of infusate in a first reservoir and drained fluid in a second reservoir and compares those weights to corresponding predetermined computed weights. When necessary, the pumping rates of the infusate, drained fluid and blood are adjusted in order to achieve a preselected amount of fluid removal from the patient's blood in a preselected time period. Application of this system and method provide repeatable and highly precise results. Alternatively, predetermined patient parameters can be monitored and the adjustment of pumping rates may be responsive to these monitored parameters. Suitable patient parameters are arterial pressure, central venous pressure, pulmonary arterial pressure, mean arterial pressure, ...

Stationary optical monitoring system for blood processing system

A blood processing system includes a centrifuge and an optical monitoring system mounted at a stationary radial position with respect to the centrifuge. A flow circuit may be mounted within the centrifuge, with an umbilicus of the flow circuit extending outside of the centrifuge. A midsection of the umbilicus is orbited around a rotational axis of the centrifuge at a uniform first speed, which causes the centrifuge to rotate at a non-uniform second speed that is approximately double the first speed. The monitoring system is configured to view the flow circuit through a radial window of the centrifuge to determine a characteristic of the flow circuit. The yoke and/or umbilicus may occasionally move into position between the monitoring system and the window, so a controller of the monitoring system is configured to determine when unobstructed light reflected through the window by the centrifuge is received by the monitoring system.

Method and apparatus for machine error detection by combining multiple sensor inputs

One of the most significant safety concerns in the automation of extracorporeal blood treatments such as dialysis is the risk of blood leakage. Extracorporeal blood treatment systems draw blood at such a high rate that a loss of integrity in the blood circuit can be serious. There are a number of mechanisms for detecting and preventing leaks, but none is perfect. This tends to limit the use of such equipment in unsupervised settings, such as the home will be limited. Some leak detection schemes can be made sensitive enough to detect the barest of leaks, but when this is done, they result in too many false positives. The invention combines information from multiple inputs to enhance sensitivity in leak detection and reduce the problem of false positives.

Systems Enabling Alternative Approaches To Therapeutic Red Blood Cell Exchange And/Or Therapeutic Plasma Exchange

Systems and methods are provided for therapeutic red blood cell exchange and/or therapeutic plasma exchange. A blood separation device includes a centrifugal separator, a spinning membrane separator drive unit, a pump system, and a controller. Blood is conveyed through a fluid flow circuit into either the centrifugal separator or the spinning membrane separator, which separates out the target blood component (red blood cells, in the case of therapeutic red blood cell exchange, or plasma, in the case of therapeutic plasma exchange). The target blood component is retained in the circuit as a waste product, while a replacement fluid is added to the remaining blood component(s), which is then conveyed to a recipient. In addition to allowing for execution of an exchange procedure using either a centrifugal separator or a spinning membrane separator drive unit, the blood separation device also allows for the use of differently sized spinning membrane separators.

DUAL CHAMBER GAS EXCHANGER AND METHOD OF USE FOR RESPIRATORY SUPPORT

The device of the present invention includes a dual chamber gas exchanger that is configured for increased flexibility and scalability for many clinical applications. The dual chamber oxygenator can be configured and used in various applications, such as in a heart-lung machine for cardiopulmonary support during cardiothoracic surgery, in an extracorporeal membrane oxygenation (ECMO) circuitry, as a respiratory assist device for patients with lung failure, and the like. The dual chamber gas exchanger features two sweep gas flow paths and two gas exchange membrane bundles enclosed in a housing structure with various blood flow distribution and gas distribution mechanisms. The gas exchanger includes an outer housing, an intermediate housing, two gas exchange fiber bundles, a blood inlet, a blood outlet, two gas inlets, two gas outlets, two gas distribution chambers and an optional heat exchanger.

HLM PUMP STOP REACTION

A heart lung machine (HLM) includes: a pump actuator; an actuator control unit (ACU) operably connected to the pump actuator; a processing unit configured to receive a set of parameter data from the actuator; a display device configured to present a subset of the set of parameter data; and an input control device operably connected to the pump actuator. The input control device includes a rotatable knob. The ACU may be configured to: determine that the pump actuator has been stopped in response to a pump-stop trigger event; determine that the rotatable knob has been rotated to a first position; and in response to determining that the rotatable knob has been rotated to the first position, starting the pump actuator.

CHRONIC PH OR ELECTROLYTE MONITORING

СИСТЕМЫ И СПОСОБЫ ДЛЯ ОПТИМИЗАЦИИ ОБЪЕМОВ ЗАБОРА ПЛАЗМЫ

REGELEINRICHTUNG IN EINEM EXTRAKORPORALEN BLUTKREISLAUF

VORRICHTUNG ZUR REGELUNG EINER BLUTPUMPE IN EINER ANLAGE ZUR EXTRACORPOREALEN HAEMODIALYSE

THERAPY FACILITY WITH TIME-FLEXIBLE BLOOD PRESSURE REGULATION

EXHAUST METHOD OF A CYCLE FOR EXTRAKORPORALE GENERAL-PURPOSE TREATMENTS OF BLOOD

Device for an extracorporeal blood treatment

The invention relates to a device for an extracorporeal blood treatment, comprising an extracorporeal blood circuit in which a dialyzer is arranged and comprising a dialysate circuit. The blood circuit is fluidically connected to a first chamber, and the dialysate circuit is fluidically connected to a second chamber of the dialyzer. The two chambers are separated by a semipermeable membrane, and a dialysate pump is provided in the dialysate circuit in order to pump the dialysis solution. The device has a control unit which is designed to operate the device in a first phase and a second phase which follows the first phase, and the dialysate pump is operated with a lower flow rate in the first phase than in the second phase and/or the dialysate pump pumps a dialysis solution with a higher concentration, with respect to at least one component, in the first phase than in the second phase.

Blood dialyzer

Filtering of a time-dependent pressure signal

A device removes first pulses in a pressure signal of a pressure sensor which is arranged in a fluid containing system to detect the first pulses, which originate from a first pulse generator, and second pulses, which originate from a second pulse generator. The first pulse generator is known to operate in a sequence of pulse cycles, each pulse cycle resulting in at least one first pulse. The device repetitively obtains a current data sample, calculates corresponding a reference value and subtracts the reference value from the current data sample. The reference value is calculated as a function of other data sample(s) in the same pressure signal. These data sample(s) may be either cycle-synchronized so as to have a corresponding location in one or more other pulse cycles (e.g. in a preceding pulse cycle) as the current data sample, or be located in proximity to the current data sample. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis ...

BLOOD PRESSURE ALARM SYSTEM FOR DIALYSIS MACHINE

WEARABLE INTERFACE FOR REMOTE MONITORING AND CONTROL OF A MEDICAL DEVICE

A wearable interface device, such as a head-mounted display, provides an augmented reality and/or display system and may be used in accordance with medical devices and the performance of medical treatments, particularly a dialysis machine and a dialysis treatment. The wearable interface device may be worn by a user, such as a health care practitioner (HCP), in connection with remotely monitoring and/or controlling the dialysis machine during the dialysis treatment. The HCP may receive alerts and/or other information concerning the dialysis treatment from the dialysis machine that are displayed on the wearable interface device and may use the wearable interface device to control the dialysis machine via the exchange of wireless signals with the dialysis machine. The wearable interface device may recognize commands from the HCP, such as gestures, to provide non-contact operation of the wearable interface device and remote control of the dialysis machine by the HCP.

DEVICE AND EXTERNAL FUNCTIONAL MEANS AND TREATMENT APPARATUS FOR THE TREATMENT OF MEDICAL FLUIDS

The present invention relates to a device (100) with at least one fluid receiving chamber (1) and at least one hydrophobic filter device, wherein a vertical line passing through the hydrophobic filter device does not intersect the fluid level (7) of fluids (5) present in the fluid receiving chamber (1). The invention further relates to an external functional device as well as a treatment device.

A METHOD FOR ASSESSING A PATIENT'S FLUID STATUS AND/OR SENSITIVITY TO FLUID REMOVAL, CONTROLLER, AND DEVICES

The present invention relates to a method for assessing a patient's sensitivity to fluid removal from his vascular system or to fluid replacement or addition regarding to his hydration state, the method comprising the step of determining a value reflecting the distribution of fluid between at least two distribution spaces of the body of the patient or changes thereof from measured or calculated values, and assessing whether the value fulfils at least one criterion. It also relates to a controller, an apparatus, a device, a digital storage means, a computer program product, and a computer program.

FILTERING OF A TIME-DEPENDENT PRESSURE SIGNAL

A device removes first pulses in a pressure signal of a pressure sensor which is arranged in a fluid containing system to detect the first pulses, which originate from a first pulse generator, and second pulses, which originate from a second pulse generator. The first pulse generator is known to operate in a sequence of pulse cycles, each pulse cycle resulting in at least one first pulse. The device repetitively obtains a current data sample, calculates corresponding a reference value and subtracts the reference value from the current data sample. The reference value is calculated as a function of other data sample(s) in the same pressure signal. These data sample(s) may be either cycle-synchronized so as to have a corresponding location in one or more other pulse cycles (e.g. in a preceding pulse cycle) as the current data sample, or be located in proximity to the current data sample. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis ...

Method as well as apparatuses for testing at least one function of a medical functional device

Blood treatment and pressure measuring equipment - with proportional anti-coagulant metering

Förbättrad rening i en konstgjord njure innehållande en pulsatorisk pump

DEVICE FOR DETERMINING THE BLOOD VOLUME AND/OR BLOOD VOLUMETRIC FLOW AND METHOD FOR OPERATING THE SAME

The invention relates to a device (1) for determining the blood volume and/or blood volumetric flow of a circulation section, comprising a fluid storage unit (2) for storing a measuring fluid (3), an injection device for the injection of the measuring fluid into the circulatory system, at least one pump device (5) disposed between the fluid storage unit and the injection device, means for determining at least one property of the measuring fluid before injection into the circulatory system, further means for determining the respective properties in the circulatory system downstream of the injection site, and an analysis device for calculating the blood volume or volumetric flow as a function of the properties determined. The invention further relates to such a device having means for conditioning the measuring fluid. The invention provides that the measuring fluid can be supplied from the fluid storage unit to a second pump device (9) by means of a first pump device (5), and from the second ...

Method for determining hemodynamic parameters during an extracorporeal hemotherapy and related device

A method and a device for determining hemodynamic parameters during an extracorporeal hemotherapy, in which the blood arrives via the arterial branch (20) of the extracorporeal circuit (9) of the hemotherapeutic device (7), which is in fluid communication with arterial section (21) of a fistula (6), into dialyzer (10) or into a filter of the hemotherapeutic device and is recirculated via the venous branch (22) of the extracorporeal circuit (9), which is in fluid communication with venous section (23) of fistula (6). The temperature TA prevailing in the arterial branch (20) of the extracorporeal circuit (9) is measured under a changing blood flow, the temperature TV of the venous branch (22) of the extracorporeal circuit being kept constant. From the determined value pairs of the arterial temperature TA and of the extracorporeal blood flow QB, those parameters of a predetermined function TA (QB) representing the temperature in the arterial branch of the extracorporeal circuit (9) are defined ...

Apparatus for extracorporeal treatment of blood including calculation of flow rates therefore

An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit (10) is configured calculate set values of two or more of the fluid flow rates based on a fluid flow rate set by the operator and on a prescribed dose value (Dset).

Regional citrate anticoagulation

A system or method automates and optimizes citrate anticoagulant supplementation in a blood filtration circuit during CRRT. A processor-based control system interfaces with a blood filtration circuit to detect patient blood flow into the circuit, detect fluid loss through a hemofilter, and sense vital electrolyte concentrations in the blood flow, and in response, control the addition of citrate, substitution fluid, and electrolyte supplements to ensure stability of plasma concentrations in post-dilution flow returned to the patient. The controller executes the method embodied as process control algorithms for calculating an optimal citrate flow rate as a function of selected, detected, and calculated system parameters. Citrate may be added to the circuit separately, or as part of a substitution solution or a dialysate.

Acoustic access disconnection systems and methods

An access disconnection system includes: an arterial line; a venous line; a transmitter configured to transmit a sound wave in one of the arterial and venous lines when connected to a patient; a receiver configured to receive the sound wave from the other of the arterial and venous lines when connected to the patient; and electronic circuitry coupled to at least one of the transmitter and receiver, the circuitry configured to send a disconnection output indicative of a change in the sound waves received by the receiver from the transmitter sufficient to expect that an access disconnection of one of the arterial line and venous lines has occurred.

Blood purification apparatus and blood purification system

A blood purification apparatus and a blood purification system that is operable with increased ease even if a blood purifier requires special treatment conditions and operational settings is used. A blood purification apparatus includes a blood purifier for giving blood purification treatment by purifying blood of a patient; and a control device that executes, in accordance with preset treatment conditions and/or operational settings, an operation for performing the blood purification treatment or an operation associated with the blood purification treatment. The blood purification apparatus includes a registering device that is capable of registering, in advance, the treatment conditions and/or operational settings corresponding to a performance, characteristic, or function of the blood purifier; and a changing device that is capable of changing the treatment conditions and/or operational settings to the treatment conditions and/or operational settings registered by the registering device ...

BLOOD PURIFICATION SYSTEM

A blood purification system that is capable of notifying any changes in the patient's condition on the basis of noninvasive vital sings of the patient that are observed during the blood purification treatment. An external information-processing apparatus includes an external input device into which a vital sign detected by a detecting device is inputtable in real time; a checking device capable of checking whether or not the vital sign inputted in real time into the external input device satisfies a predetermined condition; and an external output device capable of outputting, if it is determined by the checking device that the vital sign satisfies the predetermined condition, a result of the checking or checked information including the vital sign leading to the result of the checking to a blood purification apparatus. The checked information outputted from the external output device is displayable on a display included in the blood purification apparatus. 1) A blood purification system comprising:a blood purification apparatus capable of performing blood purification treatment in which blood of a patient that is extracorporeally circulated is purified, the blood purification apparatus including a display capable of displaying information on the blood purification treatment in real time;a detecting device capable of detecting in real time a noninvasive vital sign of the patient during the blood purification treatment; andan external information-processing apparatus capable of receiving and monitoring in real time the vital sign detected by the detecting device, an external input device into which the vital sign detected by the detecting device is inputtable in real time;', 'a checking device capable of checking whether or not the vital sign inputted in real time into the external input device satisfies a predetermined condition; and', 'an external output device capable of outputting, if it is determined by the checking device that the vital sign satisfies the ...

Acoustic access disconnection systems and methods

An access disconnection system includes a blood treatment machine including a housing, an access site detection housing separate from the blood treatment machine housing, a transmitter positioned in the access site housing and configured to transmit an ultrasound wave into a blood stream of a patient, a receiver positioned in the access site housing and configured to receive a reflection of the ultrasound wave from the blood stream of the patient; and electronic circuitry in communication with the transmitter and the receiver. The electronic circuitry is supported by the access site detection housing, and the transmitter is configured to send a wireless disconnection output to the blood treatment machine. The disconnection output is indicative of a change in the reflected ultrasound wave received by the receiver sufficient to expect that an access disconnection of one of the arterial line and the venous line has occurred.

Method and apparatus for machine error detection by combining multiple sensor inputs

One of the most significant safety concerns in the automation of extracorporeal blood treatments such as dialysis is the risk of blood leakage. Extracorporeal blood treatment systems draw blood at such a high rate that a loss of integrity in the blood circuit can be serious. There are a number of mechanisms for detecting and preventing leaks, but none is perfect. This tends to limit the use of such equipment in unsupervised settings, such as the home will be limited. Some leak detection schemes can be made sensitive enough to detect the barest of leaks, but when this is done, they result in too many false positives. The invention combines information from multiple inputs to enhance sensitivity in leak detection and reduce the problem of false positives.

Method and system for detecting or verifying a blood circuit connected to an extracorporeal blood treatment console

A method to determine a type of blood circuit attached to an extracorporeal blood treatment console including: pumping a liquid through a blood passage of the blood circuit, sensing a first pressure in: the blood passage while the passage is closed and pumping stopped, pumping an additional amount of the liquid into the blood passage while the blood passage is and remains closed and thereafter sensing a second pressure, and determine a dimensional characteristic of a fluid passage in the blood passage based on the additional amount of the liquid and the second pressure.

ADAPTIVE SYSTEM FOR BLOOD FLUID REMOVAL

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session. 1. A method carried out by a blood fluid removal system , comprising:storing a second data in a most effective to date data set; wherein the second data is data regarding system parameters employed in a first blood fluid removal session of a patient; and wherein a first data is data regarding the patient, the first data including one or more of a physiological parameter and time since last blood fluid removal session prior to the first blood fluid removal session of the patient; wherein at least one physiological parameter is measured in a dialysate;storing the second data in a least effective to date data set;determining whether at least one physiological parameter in a third data is closer to a target value than the first data; and replacing the data in the most effective to date data set with a fourth data if the third data is closer to the target value than the first data;wherein the third data is data regarding the patient, the data including one or more of a physiological parameter and time since last blood fluid removal session prior to a second blood fluid removal session of the patient; wherein at least one physiological parameter is measured in a dialysate; and wherein the fourth data is data regarding system parameters employed in the second blood fluid removal session of the patient;determining whether at least one physiological parameter in the third data is further from a target value than the first data; and replacing the data ...

Systems and methods for optimization of plasma collection volumes

A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.

Device, system and method for killing viruses in blood through electrode wires

A device for killing blood-borne pathogens, and a method of using this device to effectively remove blood-borne pathogens from the body of a human or animal is claimed. The device comprises a wire that is inserted into the blood stream of a patient, which releases metallic ions which effectively kill the pathogens. There are several embodiments, each of which has a combination of covered and uncovered portions of the wire. The wire is electrically connected to both a source of power and a Power Supply with PCB or controller/software, which controls the intensity and during of the treatment. 2. The device of claim 1 , where the electrode is a two-part electrode with a first electrode part and a second electrode part claim 1 , where the first electrode part is a proximal end unit claim 1 , where the proximal end contains a conductive pin claim 1 , where the conductive pin comprises copper claim 1 , where the conductive pin is held within a lure claim 1 , where the conductive pin allows the transfer of a low intensity direct current to the iontophoretic wire from the power supply claim 1 , where the pin can be tightened onto the second part through a tightening device claim 1 , and where the second part is a second part electrode claim 1 , where the second part electrode has a length of exposed wire at the distal end.3. The device of claim 2 , where the length of exposed wire at the distal end is a bare silver wire.4. The device of claim 2 , where the length of exposed wire at the distal end is a skived window.5. The device of claim 2 , where the tightening device is a set screw.6. The device of claim 2 , where the tightening device is a quantity of conductive glue.7. The device of claim 1 , where the second metal is combination of gold and silver.8. A device for treating a blood borne pathogen within a blood stream comprisingan iontophoretic wire, where the iontophoretic wire comprises one or more metals;a transformer, where the transformer comprises a plurality of ...

MYOCARDIAL PROTECTION SYSTEM

An embodiment includes a cardioplegia delivery system having a console, controller, and disposables. The system aides the perfusionist in cardioplegia delivery to the patient during Cardiopulmonary Bypass Surgery. The console, in conjunction with the disposables, combines blood from the heart-lung machine and crystalloid from the IV-bag in a specified ratio and then adds in a drug (arrest agent and/or additive). The electro-mechanical console incorporates a blood/crystalloid pump, temperature controllable water circulation system, pressure and temperature monitors, a sensor interface with the disposables, an arrest agent pump, an additive pump and ultra-sonic air detection sensors. The system monitors and controls the blood-crystalloid ratio, drug concentration, flow rate, pressure, temperature, and delivery route of the cardioplegia solution delivered to the patient. The system is a software-controlled system with a graphical user interface controller. The controller is utilized to initiate/stop cardioplegia delivery, monitor delivery parameters and view/save relevant case information and data. 1. A cardioplegia delivery system comprising: a first pump to pump at least one of blood or crystalloid;', 'a second pump to pump an arrest drug;', 'a third pump to pump an additive;', 'a temperature controllable water circulation system configured to couple to a reservoir of coolant;', 'a first heat exchanger (HEX) to couple to the water circulation system;', 'a first sensor to sense pressure;', 'a second sensor to sense temperature;', 'a third sensor to sense air;, 'a console includingat least one processor-based computing node coupled to a graphical user interface (GUI), the at least one processor-based computing node and GUI being configured to separably couple to the console;a first container to include the crystalloid, a second container to include the arrest drug, and a third container to include the additive, wherein the first, second, and third containers are ...

EXTRACORPOREAL BLOOD TREATMENT MACHINE COMPRISING LEAKAGE DETECTION AND METHOD OF DETECTING LEAKAGES IN DIALYSIS FLUID SYSTEMS

The invention relates to an extracorporeal blood treatment machine, such as a dialysis machine, comprising leakage detection as well as to a method of detecting leakages in the dialysis fluid circuit of a dialysis machine, wherein at least part of the dialysis fluid system to be monitored in terms of leakage is accommodated in a hermetically sealed housing and the housing is or can be ventilated in a controlled manner, and wherein a parameter, such as the air humidity of the air flowing into the housing is compared to a corresponding parameter, preferably air humidity of the air flowing out of the housing. 1. A method of detecting leakage in a dialysis fluid system of an extracorporeal blood treatment machine in which a housing including a first ventilation aperture and a second ventilation aperture and otherwise being hermetically sealed contains at least part of the dialysis fluid system to be detected in terms of leakage , the method comprising:ventilating the housing via the ventilation apertures,detecting at least one parameter of inlet air supplied to the housing and of outlet air discharged from the housing;comparing the inlet air and the outlet air detected parameters to identify a difference; anddetermining a humidity input to the housing which does not originate from the ambient air from the identified difference.2. The method according to claim 1 , wherein the treatment machine is a dialysis machine.3. The method according to claim 1 , wherein the at least one parameter includes at least one of air mass claim 1 , temperature or humidity.4. The method according to claim 1 , wherein the at least one parameter of the inlet air flowing into the housing or the outlet air flowing out of the housing are detected in discrete measuring cycles.5. The method according to claim 1 , further comprising claim 1 , when the at least one parameter is indicative of leakage claim 1 , performing a plausibility check by reversing flow of the air through the housing and ...

Methods for Treating Cholesterol-Related Diseases

The present specification is directed to systems, apparatus and methods for treating lipid-related diseases including homozygous familial hypercholesterolemia, heterozygous familial hypercholesterolemia, ischemic stroke, coronary artery disease, acute coronary syndrome, peripheral arterial disease, or renal arterial disease and its complications, and for treating the progression of Alzheimer's disease using imaging techniques to assess changes in one or more lipid-containing atheroma areas and volumes after serial infusions of delipidated plasma as compared to a baseline 1. A method for treatment of cardiovascular disease in a patient , comprising:monitoring changes in one or more blood vessels in the patient;based on said monitoring, determining if lipid-containing degenerative material is present in said one or more blood vessels;monitoring a degree of blood oxygen delivery;based on said determination of lipid-containing degenerative material and degree of blood oxygen delivery, determining a treatment protocol for said cardiovascular disease, wherein the treatment protocol comprises at least one of a placement of a stent in the patient, an administration to the patient of a composition derived from mixing a blood fraction of the patient with a lipid removing agent, or a placement of a stent in the patient together with an administration to the patient of a composition derived from mixing a blood fraction of the patient with a lipid removing agent.2. The method of claim 1 , wherein the composition is derived byobtaining the blood fraction from the patient;mixing said blood fraction with the lipid removing agent to yield modified high-density lipoproteins;separating said modified high-density lipoproteins; anddelivering said modified high-density lipoproteins to said patient.3. The method of claim 1 , further comprising:connecting the patient to a device for withdrawing blood;withdrawing blood from the patient; andseparating blood cells from the blood to yield the ...

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

An apparatus () for CRRT is provided comprising a blood circuit () with a blood removal line (), a treatment unit (), and a blood return line (). A replacement fluid container () is configured for containing a medical fluid, a pre-infusion line () has a first end (-) connected to the replacement fluid container () and a second end (-) connected to the blood removal line () and a blood pump () is active on the blood circuit. A replacement fluid pump () is active on the pre-infusion line (), a dialysate circuit () comprises an effluent line () configured for discharging fluid from the second chamber, and a control unit () is connected to the replacement fluid pump () and to the blood pump () and is configured for performing a rinse-back procedure for restituting blood to a patient. The rinse-back procedure comprises conveying blood contained in the blood circuit () towards the second end (-) of the blood return line () using the medical fluid. 117-. (canceled)18. An apparatus for continuous renal replacement therapy comprising:a blood circuit comprising a blood removal line, a treatment unit, and a blood return line, the blood treatment unit comprising a semipermeable membrane, a first chamber, and a second chamber, the semipermeable membrane being configured for separating the first chamber from the second chamber, the blood removal line having a first end destined to be connected to a vascular system of a subject and a second end connected to an inlet port of the first chamber, the blood return line having a first end connected to an outlet port of the first chamber and a second end destined to be connected to the vascular system;a replacement fluid container configured for containing a medical fluid;an infusion line having a first end connected to the replacement fluid container and a second end connected to the blood circuit;a blood pump active on the blood circuit;a replacement fluid pump active on the pre-infusion line; anda control unit connected to the ...

Dialysis Catheters With Integrated Fluid Status Sensing and Related Systems and Methods

A dialysis catheter with an elongate body has a distal end defining blood removal and return ports communicating with internal blood removal and return lumens extending through the elongate body. A sensing pathway is disposed in or on the elongate body. A vascular dimension sensor is provided to dynamically measure changes in dimension of the SVC or IVC during dialysis. The sensor communicates with a control system and may be controlled or positioned via the communication pathway of the catheter body. Systems disclosed included integrated closed-loop treatment based on monitored vascular dimension input. Methods included patient optimized treatments incorporating treatment modulation based on dynamic vascular dimension monitoring.

TEMPERATURE MANAGEMENT SYSTEM FOR PATIENTS DURING STATIONARY AND MOBILE ECLS/ECMO THERAPY

The present invention relates to a system () for temperature management for patients in stationary and mobile ECLS and/or ECMO therapy, with at least one disposable () and a fluid circuit (), wherein the disposable () comprises at least one reservoir () or bag provided with at least one supply line () and a drain line (), further provided at least one pumping unit element () as part of the disposable (), by means of which liquid in the reservoir () or bag can be pumped through the fluid circuit ().

APPARATUS AND A METHOD FOR EXTRACORPOREAL BLOOD TREATMENT

An apparatus for extracorporeal blood treatment comprises a sensor () for emitting a signal indicating a variation in blood volume (ΔBv″) of an individual () subjected to extracorporeal blood treatment and a sensor () for emitting a signal indicating a weight loss of the individual. A control unit () receives the signals, compares the ratio between the relative variation of blood volume (ΔBv/BV) and the relative variation of weight loss (AWL/TW) of the individual with a desired value, and controls the weight loss of the individual on the basis of the comparison. The apparatus enables automatically controlling a dialysis, preventing some complications due to hypotension. 1. (canceled)228-. (canceled)30. The method of claim 29 , wherein controlling the weight loss system comprises controlling a weight loss rate for the individual (WLR) as a function (II) of the desired value of the refilling index (IR) and the calculated value of the refilling index (IR):{'br': None, 'i': WLR', '=f', 'IR', ';IR, 'sub': i', 'DES', 'CAL, '()\u2003\u2003(II)'}32. The method of claim 29 , comprising verifying whether a relative blood volume variation and a relative weight loss variation of the individual is in a predetermined relation with the desired value of the refilling index (IR) and controlling the weight loss system on the basis of the verification claim 29 , the relative blood volume variation being a ratio between the blood volume variation (ΔBV) and the total blood volume of the individual (BV) claim 29 , the relative weight loss variation being a ratio between the weight loss variation (ΔWL) and the total weight (TW) of the individual or the body water weight (BWW) of the individual.33. The method of claim 29 , comprising verifying whether a ratio between a percentage relative blood volume variation and a percentage relative weight loss variation of the individual is in a predetermined ratio with a desired value and controlling the weight loss system on the basis of the ...

Blood pump

A blood pump comprising a cartridge, the cartridge comprising a first recess therein, said first recess having a surface, and a flexible diaphragm closing said first recess, the first recess and the flexible diaphragm defining a first pump chamber, said first pump chamber having an inlet and an outlet wherein the flexible diaphragm of the first pump chamber is movable between a first position, separated in use from the surface of the first recess, in which said first pump chamber has a maximum volume, and a second position, substantially adjacent to the surface of the first recess, in which said first pump chamber has a minimum volume a pump driver arranged to interface with the cartridge, said pump driver operable to move the flexible diaphragm of the first pump chamber in a first direction into said first recess to, in use, pump blood from the chamber and to move the flexible diaphragm of the first pump chamber in a second direction away from the first recess to, in use, draw blood into said first pump chamber, wherein the pump driver controls the movement of the flexible diaphragm of the first pump chamber such that the flexible diaphragm of the first pump chamber moves toward said first position at a first speed and moves toward said second position at a second speed, said second speed being greater than said first speed.

Pressure Detector

A pressure detector that includes a case connectable to a flow route for liquid, and a membrane member attached inside the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion, the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion. The pressure detector includes an inlet port including a connecting portion connectable to the flow route for the liquid, and a flow-route portion through which the liquid flows into an inlet opening of the liquid-phase portion; and an outlet port including a connecting portion connectable to the flow route for the liquid, and a flow-route portion through which the liquid having flowed into the liquid-phase portion is discharged from an outlet opening. At least one of the flow-route portion of the inlet port and the flow-route portion of the outlet port is configured such that an incoming direction or an outgoing direction of the liquid is inclined with respect to an attaching plane defined for the membrane member. 1. A pressure detector comprising:a case connectable to a flow route for liquid, anda membrane member attached inside the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion,the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion, the pressure detector comprising:an inlet port including a connecting portion connectable to the flow route for the liquid, and a flow-route portion through which the liquid flows into an inlet ...

Pressure Detector

A pressure detector including a case connectable to a flow route and attachable to a predetermined attaching surface; and a membrane member attached inside the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion, the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion. The pressure detector includes an inlet port including a connecting portion connectable to the flow route, and a flow-route portion through which the liquid flows into an inlet opening of the liquid-phase portion; and an outlet port including a connecting portion connectable to the flow route, and a flow-route portion through which the liquid having flowed into the liquid-phase portion is discharged from an outlet opening. The outlet opening is positioned in a part of the liquid-phase portion that includes a highest point in a vertical direction in a state where the case is attached to the predetermined attaching surface, and the outlet port extends obliquely upward from the outlet opening. 1. A pressure detector comprising:a case connectable to a flow route for liquid and attachable to a predetermined attaching surface; anda membrane member attached inside the case and with which a liquid-phase portion to be supplied with the liquid in the flow route and a gas-phase portion to be supplied with gas are separated from each other, the membrane member being displaceable in accordance with a pressure of the liquid supplied to the liquid-phase portion,the pressure detector detecting the pressure of the liquid in the flow route by detecting a pressure in the gas-phase portion, the pressure detector comprising:an inlet port including a connecting portion connectable to the flow route for the liquid, and a ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. A medical treatment system , comprising:a flow balancing fluid management element configured to pump fluid from a patient interface device during a treatment and configured to pump fluid into the patient interface device during the treatment, the flow balancing fluid management element including a synchronization mechanism that is configured to proportion flow to and from the patient interface device in a predefined ratio during the treatment;the patient interface device being a device that interfaces with a patient fluid compartment including at least one of a dialyzer, a hemofilter, a hemodiafilter, an ultrafilter, and a plasmapheresis device;a proportioning bypass channel that includes a proportioning bypass pump and configured to pump fluid to or from the patient interface device in a predefined amount that has a predefined relationship to flows in said flow balancing fluid management element so as to produce a predefined net withdrawal from, or infusion into, a patient;a controller configured to control at least the proportioning bypass pump and including a processor programmed to regulate a rate of flow through the proportioning bypass pump to achieve the predefined net withdrawal from, or infusion into, the patient; andan infusion circuit connectable to a source of fluid and including an infusion circuit pump and connected to one or both of blood lines connected to a patient access, whereinat least a portion of the infusion circuit is selectively connectable to the proportioning bypass channel such that the ...

Modular assembly for a portable hemodialysis system

A modular assembly for a portable hemodialysis system may include a dialysis unit, e.g., that contains suitable components for performing hemodialysis, such as a dialyzer, one or more pumps to circulate blood through the dialyzer, a source of dialysate, and one or more pumps to circulate the dialysate through the dialyzer, and a power unit having a housing that contains suitable components for providing operating power to the pumps of the dialysis unit. The power unit may be selectively connected to the dialysis unit and provide power (e.g., pneumatic power in the form of pressure and/or vacuum) to the dialysis unit for the pumps when connected to the dialysis unit, but may be incapable of providing power to the dialysis unit when disconnected from the dialysis unit. The dialysis unit and the power unit are sized and weighted to each be carried by hand by a human.

Extracting Constituent Molecules from Blood or Other Liquids

Excess water can be removed from blood by passing the blood through channels that are surrounded by nanotubes with spaces therebetween. Each channel is wide enough for blood to flow through, and the nanotubes are spaced close enough to each other to retain the blood within the channels. Gas passing through the spaces between the nanotubes outside the channels comes into contact with the blood at the outer boundaries of the channels, and the excess water in the blood evaporates into the gas. In other embodiments, an undesirable molecule (e.g., ammonia) can be removed from blood by passing the blood through channels that are surrounded by nanotubes with spaces therebetween. Gas passing through the spaces between the nanotubes outside the channels comes into contact with the blood at the outer boundaries of the channels, and the undesirable molecule in the blood diffuses into the gas. 1. A method for removing excess water from blood , the method comprising:providing a plurality of fluid flow channels that are surrounded by hydrophobic nanotubes with diameters between 1 and 100 nm, with spaces between the nanotubes, each of the channels having an outer boundary, an inflow end, and an outflow end, wherein each of the channels is wide enough for blood to flow through, and wherein the nanotubes are spaced close enough to each other to retain the blood within the channels when the blood is flowing through the channels;passing the blood through the channels; andpassing a gas through the spaces between the nanotubes outside the channels so that the gas comes into contact with the blood at the outer boundaries of the channels until the excess water in the blood evaporates into the gas.2. The method of claim 1 , further comprising:determining whether a sufficient amount of water has been removed; anddiscontinuing the passing of the blood after a sufficient amount of water has been removed.3. The method of claim 1 , wherein the nanotubes are carbon nanotubes.4. The method of ...

SIMULTANEOUS ECMO AND CRRT

A controller for controlling an apparatus comprising a blood pump, oxygenator, and blood filtering system connected together by blood flow tubing and to a patient to circulate blood from the patient through the apparatus and back to the patient, to oxygenate and filter the blood, the controller comprising at least one communication interface operable to receive signals generated responsive to monitored parameters characterizing blood flow and/or quality of blood from the patient circulating through the apparatus and configured to: determine values for the monitored parameters based on the monitoring signals; determine whether or not a value determined for a given monitored parameter for blood circulating through the apparatus is within a normative range for the parameter; and generate an alarm to alert an operator of the system if the value is not within the normative range. 1. A controller for controlling an apparatus comprising a blood pump , oxygenator , and blood filtering system connected together by blood flow tubing configured to circulate blood from a patient through the apparatus and back to the patient , to oxygenate and filter the blood , the controller comprising:at least one communication interface operable to receive wireless and/or wire monitoring signals generated responsive to monitored parameters characterizing blood flow and/or quality of blood from the patient circulating through the apparatus at locations in and outside of the blood filtering system;a memory comprising a database having data that defines normative ranges for values of the monitored parameters; anda processor comprising computer executable instructions executable to:determine values for the monitored parameters based on the monitoring signals;determine whether or not a value determined for a given monitored parameter for blood circulating through the apparatus is within the normative range for the parameter; andgenerate an alarm if the value is not within the normative range.2. ...

Device for Automatically Establishing the Venous Inflow to a Blood Reservoir of an Extracorporeal Blood Circulation System

A device for establishing venous inflow to a blood reservoir of an extracorporeal blood circulation system includes a restricting unit for restricting a venous inflow line and a vacuum unit for supplying vacuum to the blood reservoir. The device includes a control unit that, upon setting the desired venous flow rate, automatically supplies a first actuating signal to the restricting unit for restricting venous inflow to the blood reservoir and supplies a second actuating signal to the vacuum unit for establishing a degree of vacuum within the blood reservoir, so as to achieve the set venous flow rate. The device includes a venous flow sensor. 1. A device for establishing venous inflow to a blood reservoir of an extracorporeal blood circulation system including a venous inflow line from a patient to the blood reservoir and an arterial outflow line extending from the blood reservoir to the patient , the device comprising:a restricting unit configured for clamping the venous inflow line in order to act on the venous inflow amount to the blood reservoir in the range below a basic value, the basic value comprising a value established by gravitational conveyance while the inflow line is not restricted by the restricting unit;a vacuum unit configured for applying a vacuum to the blood reservoir in order to act on the venous inflow amount to the blood reservoir in the range above the basic value;a control device that includes a single operating element having a plurality of operating positions and configured to be manipulated in a single manipulation by a user to establish both a degree of closure of the venous inflow line and an amount of vacuum in the blood reservoir for venous inflow to the blood reservoir at, above or below the basic value; anda venous flow sensor disposed on the venous inflow line and configured to measure a venous flow rate of the circulating blood in the venous inflow line and to send a venous flow rate signal representing the venous flow rate to the ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. An apparatus for controlling flow in a fluid circuit , comprising:a treatment machine with flow regulators and sensors, the flow regulators including pumping actuators;the treatment machine having a controller connected to control the flow regulators and receive signals from the sensors to implement a therapeutic treatment by regulating a flow of blood and treatment fluid when a predefined fluid circuit is connected in operative engagement with said flow regulators and sensors;where the predefined fluid circuit has a plurality of fluid lines including first and second fluid lines and other fluid lines all interconnected by the fluid circuit, each of the fluid lines being used to transport a fluid during a treatment mode in order to implement said therapeutic treatment;the flow regulators being controlled by said controller, during a synchronization mode thereof, to selectively block flow in first ones of said fluid lines while selectively pumping fluid serially through second ones of said fluid lines such that first and second pumping actuators pump fluid in a fixed volume channel that interconnects the second ones of said fluid lines, the fixed volume channel being sealed in part by said first ones of said fluid lines;the controller, during said synchronization mode, regulating relative speeds of the first and second pumping actuators responsively to at least one of the sensors to estimate commanded rates of said first and second pumping actuators corresponding to equal flows throughout said fixed volume channel and ...

AUGMENTED REALITY INTERFACE FOR MEDICAL DEVICE

A wearable interface device, such as a head-mounted display, provides an augmented reality and/or display system and may be used in accordance with medical devices and the performance of medical treatments, particularly a dialysis machine and a dialysis treatment. The wearable interface device may be worn by a user, such as a health care practitioner (HCP), in connection with remotely monitoring and/or controlling the dialysis machine during the dialysis treatment. The HCP may receive alerts and/or other information concerning the dialysis treatment from the dialysis machine that are displayed on the wearable interface device and may use the wearable interface device to control the dialysis machine via the exchange of wireless signals with the dialysis machine. The wearable interface device may recognize commands from the HCP, such as gestures, to provide non-contact operation of the wearable interface device and remote control of the dialysis machine by the HCP. 1. A method of remotely interfacing with a medical device , comprising:providing a head-mounted wearable interface device that enables remote interfacing with the medical device by a user wearing the wearable interface device;wirelessly exchanging signals between the wearable interface device and the medical device, wherein the signals correspond to a treatment performed using the medical device;processing at least one of the signals at the wearable interface device to generate information corresponding to the treatment performed using the medical device;displaying the information on a screen of the wearable interface device; andaugmenting a real view through the wearable interface device with information corresponding to the treatment performed using the medical device.2. The method according to claim 1 , wherein the medical device includes a dialysis machine.3. The method according to claim 1 , further comprising:recognizing, at the wearable interface device, at least one non-contact command input by the ...

SYSTEMS AND METHODS FOR TREATING BLOOD

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to pump blood in a fluid flow path at a collective rate over 5 liters per minute. The system may include one or more heat exchangers operable to heat at least a portion of the blood to a temperature of at least 42 degrees Celsius and to allow the blood to cool one or more degrees following heating. The system may include one or more convection dialysis modules configured to perform convection dialysis on at least a portion of the blood at least after the one or more heat exchangers allow the blood to cool one or more degrees. 174-. (canceled)75. A method for treating cancer , comprising:heating a human body to a core temperature between 42 and 43.2 degrees Celsius, wherein blood from the human body is flowing outside of the human body in a fluid flow path; andremoving carbon dioxide from at least a portion of the blood flowing in the fluid flow path.76. The method of claim 75 , further comprising adding oxygen to at least a portion of the blood.77. The method of claim 75 , wherein carbon dioxide is removed from at least a portion of the blood by causing at least a portion of the blood to flow through at least one membrane.78. The method of claim 77 , wherein the at least one membrane collectively has an effective surface area greater than 1.8 square meters.79. The method of claim 75 , further comprising causing the production of reactive oxygen species within the human body by adding a substance to at least a portion of the blood outside of the human body.80. The method of claim 75 , further comprising performing convection dialysis on at least a portion of the blood at a rate between 0.5 and 1.8 liters per minute.81. The method of claim 75 , further comprising pumping blood from the human body into the fluid flow path at a rate between 4 and 7 liters per minute.82. The method of claim 75 , wherein the blood is pumped in the ...

CATHETER FOR EXTRACORPOREAL BLOOD CIRCULATOR

A catheter for an extracorporeal blood circulator disperses a flow of blood flowing out from a blood feeding hole to reduce the impact of blood collision on a living organ. The catheter includes a blood feeding lumen extending in an axial direction and a blood feeding hole communicating with a distal end of the blood feeding lumen, and a side portion of the blood feeding hole on the proximal side facing the blood feeding lumen is cut out to a bottom portion of the blood feeding hole. 1. A catheter extending in an axial direction for allowing passage of blood , comprising:a tube defining a blood feeding lumen extending in the axial direction to a distal end; anda rigid connector receiving the tube and having a side hole;wherein the tube comprises a blood feeding hole at a distal end of the blood feeding lumen cooperating with the side hole to define an opening with a proximal edge facing the blood feeding lumen that is cut out to a bottom portion of the blood feeding hole so that the proximal edge is substantially perpendicular to the axial direction, and wherein the opening has an outer shape decreasing gradually in width from the proximal edge to the distal end.2. The catheter according to claim 1 , wherein the blood feeding hole further comprises a distal wall formed at the distal side of the blood feeding hole as an extension of a bottom planar wall of the tube so as to be curved into a concave shape toward the distal side in the axial direction.3. The catheter according to claim 1 , further comprising a rib extending between the distal side of the blood feeding hole and the proximal side of the blood feeding hole claim 1 , configured to prevent a biological tissue from being caught by the blood feeding hole.4. The catheter according to claim 3 , wherein the rib is comprised of a rod-like member extending substantially linearly along the axial direction and is formed by a portion of the connector extending across the side hole.5. The catheter according to claim 1 ...

ARTIFICIAL INTELLIGENCE (AI) POWERED ANALYSIS OF OBJECTS OBSERVABLE THROUGH A MICROSCOPE

Introduced here are computer programs and associated computer-implemented techniques for autonomously analyzing images of blood smears that are captured during an examination session. Initially, an optical adapter device may be attached to the eyepiece of a microscope. The optical adapter device may be designed to facilitate alignment of the camera of an electronic device with the eyepiece of the microscope. As part of an examination session, the electronic device may generate a series of images of a blood smear on a slide that is viewable through the eyepiece. Generally, the electronic device is detachably connectable to the optical adapter so that it can be removed from the optical adapter device after generating the series of images. The series of images can be partially or entirely processed by a diagnostic platform in an automated manner using artificial intelligence or machine learning algorithms in order to streamline the diagnostic process. 1. A method comprising:obtaining, by a diagnostic platform, an image generated by an electronic device of a slide viewable through an eyepiece of a microscope;determining, by the diagnostic platform, that the image should be analyzed as part of an examination session;identifying, by the diagnostic platform, a detection model designed to detect instances of objects in a class when applied to images; 'wherein each output is indicative of an instance of an object in the class;', 'applying, by the diagnostic platform, the detection model to the image to generate at least one output,'}inferring, by the diagnostic platform based on the at least one output, a health state of an individual whose blood is smeared on the slide; andgenerating, by the diagnostic platform, a visualization component that specifies the health state.2. The method of claim 1 , wherein the image is one of a series of images obtained by the diagnostic platform.3. The method of claim 2 , wherein said determining comprises:examining metadata that accompanies ...

BLOOD CIRCUIT ASSEMBLY FOR A HEMODIALYSIS SYSTEM

A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient. 1. A blood circuit assembly for a dialysis unit , comprising:an organizing tray;a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient;an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit;a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit; anda pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.2. The blood circuit assembly of claim 1 , further comprising an anticoagulant connection for engaging with an anticoagulant source and providing anticoagulant into the circuit.3. The blood circuit assembly of claim 2 , further comprising a pump for pumping anticoagulant from the anticoagulant source to the circuit.4. The blood circuit assembly of claim 3 , wherein the pair of pneumatic pumps claim 3 , the anticoagulant connection claim 3 , and the anticoagulant pump are part of a pump cassette.5. The blood circuit assembly of claim 4 , wherein the inlet blood line connector is connected to an inlet for the pump cassette claim 4 , an ...

AIR TRAP CHAMBER AND EXTRACORPOREAL CIRCULATION CIRCUIT

A chamber body is provided, as regions where the liquid flows, with: an upper region including an area from the inner surface of the upper wall to the introduction pipe; a lower region connected to the outlet port; and a connection region connecting the upper region and the lower region. The inner circumferential surface of the upper region has a larger diameter than the inner circumferential surface of the lower region. As a result of diameter reduction from the connection portion relative to the upper region to the connection portion relative to the lower region, an inclined surface is formed on the inner circumferential surface of the connection region. 1. An air trap chamber comprising:a chamber body that has a generally cylindrical shape and has one end defined with respect to a central axis and covered with a top wall having an inlet, and the other end having an outlet, so that a liquid flows down from the inlet to the outlet; andan inlet pipe that extends from the inlet into the chamber body, and has an ejection port being an end opening and provided in the inner peripheral surface of the chamber body facing in a circumferential direction, wherein an upper region extending from the top wall inner surface to the inlet pipe,', 'a lower region connected to the outlet, and', 'a connection region connecting the upper region and the lower region,, 'the chamber body has the following regions in which liquid flowsthe inner peripheral surface of the upper region has a larger diameter than the inner peripheral surface of the lower region, andthe inner peripheral surface of the connection region has an inclined surface formed by reducing the diameter from a point of connection to the upper region to a point of connection to the lower region.2. The air trap chamber according to claim 1 , wherein the inner peripheral surface of the connection region has an oblique circular truncated cone shape having a vertical surface parallel with the inner peripheral surface of the ...

Automatic Detection and Adjustment of a Pressure Pod Diaphragm

A system for controlling the position of a diaphragm in a diaphragm-containing pressure pod, is provided. The system can include a peristaltic pump, a pressure pod having a flow-through fluid side and a gas side that are separated by a diaphragm, and a pressure sensor operatively connected to the gas side. The pressure sensor is configured to sense pulses of pressure resulting from movement of the diaphragm and caused by the action of the peristaltic pump. A gas source and a valve can be in fluid communication with the gas side of the pressure pod and can be configured to provide gas to, or vent gas from, the gas side. A controller receives pressure signals from the pressure sensor and controls the valve in response, and in so doing, controls the position of the diaphragm. Methods for positioning the diaphragm are also included. 1. A system for controlling the position of a diaphragm in a diaphragm-containing pressure pod , the system comprising;a fluid pump:a pressure pod comprising an interior defining a flow-through fluid side and a gas side, the flow-through fluid side and the gas side being separated from one another by a diaphragm;a fluid conduit in fluid communication with the flow-through fluid side and operatively positioned with respect to the fluid pump such that the pump can move fluid through the conduit and force fluid through the flow-through fluid side of the pressure pod;a pressure sensor operatively connected to the gas side of the pressure pod and configured for sensing pressure resulting from movement of the diaphragm;a gas source in fluid communication with the gas side of the pressure pod and comprising a valve configured to provide fluid communication between the gas side and the gas source, the valve also being configured to interrupt communication between the gas side and the gas source; anda controller configured to (1) receive a pressure signal generated by the pressure sensor, (2) compare the pressure signal received to a predetermined ...

Biomedical Apparatus for Pumping Blood of a Human or an Animal Patient through a Secondary Intra- or Extracorporeal Blood Circuit

A biomedical apparatus for pumping blood of a human or an animal patient through a secondary blood circuit is provided, including a blood pump (), an inlet duct () and an outlet duct () for guiding blood of the patient to the blood pump () and back to the patient. The device further includes a measuring device () for measuring a physical parameter of the heart () or of a blood vessel, and a controller () for regulating the power of the blood pump (). The measuring device () is adapted to be arranged inside the heart () or the blood vessel, and the controller is configured to determine an estimate for an inner volume of the heart () or of the blood vessel based on the physical parameter and is configured to regulate the power of the blood pump () depending on this estimate. 1. A biomedical apparatus for pumping blood of a human or an animal patient through a secondary intra- or extracorporeal blood circuit , comprisinga blood pump for pumping blood,an inlet duct connected to the blood pump, for being inserted into a patient's circulatory system, in order to guide blood of the patient to the blood pump,an outlet duct connected to the blood pump, for being inserted into the patient's circulatory system, in order to guide blood from the blood pump back to the patient's circulatory system,a measuring device for measuring at least one physical parameter of the heart or of a blood vessel of the patient, the measuring device being adapted to be arranged inside the heart or the blood vessel and being adapted to send out an electromagnetic or a mechanical wave, anda controller being configured to determine an estimate for an inner volume of the heart or of the blood vessel based on the measured physical parameter and being configured to regulate the power of the blood pump depending on this estimate.2. The biomedical apparatus as claimed in claim 1 , wherein the measuring device is arranged on the inlet duct.3. The biomedical apparatus as claimed in claim 1 , wherein the ...

Intersession monitoring for blood fluid removal therapy

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patent parameters. By comparing the patient's current parameters to past parameters in response to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session.

SYSTEMS AND METHODS FOR MONITORING AND CONTROLLING FLUID BALANCE DURING A BIOLOGICAL FLUID PROCEDURE

Described is a method for controlling fluid volume balance. A controller is configured with a first set of inputs comprising a hematocrit, a total blood volume, and an ACD ratio. A maximum extracorporeal RBC amount during the procedure is estimated based on the first set of inputs. A fluid circuit is primed with a priming fluid. Whole blood is drawn from a blood source and separated into a RBC component, a target cell component, and a plasma component. The target cell component is directed to a product container. The product container comprising the target cell component is treated. A treated target cell component, a portion of the RBC component remaining in the fluid circuit, and/or a portion of the plasma component remaining in the fluid circuit are returned to the blood source. A first response action is provided if the maximum extracorporeal RBC amount estimated is above a programmed limit. 1. A system for monitoring and controlling fluid balance during an extracorporeal photopheresis procedure , comprising:a disposable fluid circuit comprising a product container configured to receive a target cell component;a separator configured to work in association with the disposable fluid circuit, the separator comprising a chamber configured to rotate about a rotational axis and convey whole blood from a blood source into an inlet region of the chamber for separation into a red blood cell component, a plasma component, and the target cell component; estimate an end-of-procedure fluid balance by calculating a total volume of anticoagulant solution having a citrate concentration to be used for the procedure, wherein the end-of-procedure fluid balance is estimated based on manual or automatic inputs comprising an ACD ratio relating unanticoagulated extracorporeal whole blood to anticoagulant solution, an amount of whole blood to process, a citrate infusion threshold rate, a patient body weight associated with the blood source, and a total blood volume of the blood source ...

Dialysis Systems and Methods

This invention relates to dialysis systems and methods. In some implementations, a method includes applying vacuum pressure to a device of a dialysis system, and then determining, based on a detected fluid level or measured pressure, whether the device is functioning properly.

BLOOD PURIFICATION APPARATUS AND BLOOD PURIFICATION SYSTEM

A blood purification apparatus and a blood purification system that is operable with increased ease even if a blood purifier requires special treatment conditions and operational settings is used. A blood purification apparatus includes a blood purifier for giving blood purification treatment by purifying blood of a patient; and a control device that executes, in accordance with preset treatment conditions and/or operational settings, an operation for performing the blood purification treatment or an operation associated with the blood purification treatment. The blood purification apparatus includes a registering device that is capable of registering, in advance, the treatment conditions and/or operational settings corresponding to a performance, characteristic, or function of the blood purifier; and a changing device that is capable of changing the treatment conditions and/or operational settings to the treatment conditions and/or operational settings registered by the registering device, in accordance with the blood purifier to be used in the blood purification treatment. 1. A blood purification apparatus that includes:a blood purifier for giving blood purification treatment by purifying blood of a patient; anda control device that executes, in accordance with preset treatment conditions and/or operational settings, an operation for performing the blood purification treatment or an operation associated with the blood purification treatment,the blood purification apparatus comprising:a registering device that is capable of registering, in advance, the treatment conditions and/or operational settings corresponding to a performance, characteristic, or function of the blood purifier; anda changing device that is capable of changing the treatment conditions and/or operational settings to the treatment conditions and/or operational settings registered by the registering device, in accordance with the blood purifier to be used in the blood purification treatment.2. The ...

Blood Purification System

A blood purification system is provided that is capable of effectively utilizing accumulated histories stored during blood purification treatment and that helps quickly and accurately grasp whether the current transition of a particular parameter is normal when compared with a transition of the particular parameter that is estimated from the histories. The blood purification system includes an extracting device capable of searching histories accumulated in a storage device and extracting, as an approximate history, a history including the particular parameter approximate to the particular parameter observed at the current time in the current session of blood purification treatment; an estimating device that estimates a transition of the particular parameter to be observed after the current time in the current session of blood purification treatment from the approximate history extracted by the extracting device; and a display control device capable of displaying the transition of the particular parameter estimated by the estimating device and the transition of the particular parameter observed in the current session of blood purification treatment simultaneously on a display.

ACUTE RENAL REPLACEMENT THERAPY APPARATUS

A renal therapy apparatus including at least two feedback controls is disclosed. Each control includes an estimated volume calculator to calculate an estimated volume based on a set flow, a comparator to compare the estimated volume with a measured volume, a volume deviation determining means to determine a volume deviation based on the comparison, a correction calculator to calculate a correction based on the volume deviation, a flow control generator to generate a flow control signal based on the calculated correction amount and the set flow, and a feedback control output to output the controlled flow control signal to a pump associated with each feedback control. A flow correction distributor includes an input to receive correction signals from the correction calculator, a limited correction signal calculator to calculate a limited correction signal for the input correction required signals, and an output to output each calculated limited correction signal to the feedback control from which its underlying correction required signal has been received. 110-. (canceled)11. An acute renal replacement therapy apparatus , comprising: an estimated volume calculator configured to calculate an estimated volume based on a set flow;', 'a comparator configured to compare the estimated volume with a measured volume;', 'a volume deviation determining means configured to determine a volume deviation based on the comparison of the estimated and measured volumes;', 'a correction calculator configured to calculate a correction amount and output a correction signal based on the determined volume deviation;', 'a flow control configured to generate a controlled flow control signal based on the calculated correction amount and the set flow; and', 'a feedback control output configured to output the controlled flow control signal to a pump individually associated with each feedback control in order to at least one of forward fluid from a fluid source or pull fluid into a fluid sink; and ...

Blood Purification System

A blood purification system is provided that is capable of effectively utilizing histories stored during blood purification treatment and that helps realize history search suitable for individual purposes of extraction, thereby increasing the reliability of information to be extracted and displayed. The blood purification system includes an extracting unit that searches for and extracts any history satisfying a predetermined condition from among histories stored in a storage unit, an excluding unit f that excludes any of the histories stored in the storage unit from an object of search performed by the extracting unit, and a display control unit that controls various pieces of information based on the history extracted by the extracting unit to be displayed on a display unit. 1. A blood purification system comprising:a blood purification apparatus that gives blood purification treatment to a patient;a managing apparatus that communicates with the blood purification apparatus in such a manner as to transmit and receive information on the blood purification treatment to and from the blood purification apparatus, the managing apparatus including a storage unit that stores the information on the blood purification treatment as a history for each treatment session in a time course with progress of the treatment; anda display unit provided to the blood purification apparatus or to the managing apparatus and that displays the information on the blood purification treatment, an extracting unit that searches for and extracts any history satisfying a predetermined condition from among the histories stored in the storage unit;', 'an excluding unit that excludes any of the histories stored in the storage unit from an object of search performed by the extracting unit; and', 'a display control unit that controls various pieces of information based on the history extracted by the extracting unit to be displayed on the display unit., 'wherein the blood purification system includes ...

Localized Therapy Delivery and Local Organ Protection

A system for perfusing a localized site within a body includes a catheter assembly having a venous access line that is adapted to deliver perfusate to the localized site, a venous or arterial drainage line adapted to drain perfusate from the localized site, and an occlusion device adapted to prevent some or substantially all physiological blood flow between the localized site and the systemic circulation of the body during and in the course of perfusing and draining perfusate to and from the localized site. The system may include a blood circuit associated with the catheter assembly to facilitate blood conditioning for use as the perfusate, in the course of a controlled perfusion and/or drainage of untreated, treated, or inactivated treated blood to and from the localized site. A delivery machine may control the blood circuit and catheter assembly in order to both deliver perfusate to, and drain some or all perfusate from, the localized site in a manner that provides perfusate to substantially only the localized site.

Dialysis Systems and Methods

This invention relates to dialysis systems and methods. In some implementations, a method includes applying vacuum pressure to a device of a dialysis system, and then determining, based on a detected fluid level or measured pressure, whether the device is functioning properly. 1. A method , comprising:applying vacuum pressure to an air release device of a dialysis system, the air release device comprising a vent;after applying the vacuum pressure to the air release device, detecting a fluid level within the air release device; anddetermining, based on the fluid level within the air release device, whether the air release device is functioning properly.2. The method of claim 1 , wherein determining whether the air release device is functioning properly comprises determining whether the vent of the air release device is functioning properly.3. The method of claim 1 , wherein the fluid level within the air release device is detected by a level detector of the dialysis system claim 1 , and the level detector is positioned adjacent the air release device.4. The method of claim 3 , wherein the level detector comprises a transmitter configured to emit ultrasonic signals and a receiver adapted to receive ultrasonic signals.5. The method of claim 3 , wherein the level detector is connected to a control unit of the dialysis system in a manner such that signals related to the detected fluid level can be transmitted to the control unit.6. The method of claim 1 , wherein applying vacuum pressure to the air release device comprises closing off lines upstream and downstream of the air release device and activating a pump to draw fluid out of the air release device.7. The method of claim 6 , wherein closing off the line upstream of the air release device comprises turning off a pump configured to circulate fluid through the air release device claim 6 , and closing off the line downstream of the air release device comprises clamping the line downstream of the air release device.8. ...

BLOOD PURIFICATION DEVICE FEEDBACK METHOD

A method for providing feedback on an expected and/or required user interaction in a blood purification device is disclosed. The method includes monitoring, at a current position in an operational flow of the blood purification device, whether a user interaction is expected and/or required in a subsequent step in the operational flow. If it is determined in the monitoring step that a user interaction is required and/or expected, the kind of required and/or expected user interaction is determined. A user interaction feedback indicating the determined kind of user interaction required and/or expected in the at least one subsequent step is then proactively activated at an active element corresponding to the user interaction in a graphical user interface. 19-. (canceled)10. A method for providing feedback on at least one of an expected or required user interaction in a blood purification device , comprising the steps of:monitoring, at a current position in an operational flow of the blood purification device, whether a user interaction is at least one of expected or required in at least one subsequent step in the operational flow;if it is determined in said monitoring step that the user interaction is at least one of required or expected, determining a kind of user interaction for the at least one required or expected user interaction; andproactively activating a user interaction feedback indicating the determined kind of user interaction for the at least one required or expected user interaction in said at least one subsequent step at an active element corresponding to the at least one required or expected user interaction in a graphical user interface.11. The method according to claim 10 , further comprising the step of:selecting a static or an animated user interaction feedback as the user interaction feedback based on the determined kind of user interaction.12. The method according to claim 10 , wherein said proactively activating step comprises activating said user ...

PULSATILE FLOW BLOOD PUMP

The invention is about a next-generation blood pump that provides pulsatile blood flow, and has been developed for cardiopulmonary by-pass devices used for maintaining extracorporeal blood circulation during heart surgeries and the supportive devices of circulation system. This device is technically a sort of synchronous power-assisted motor employing direct driver technology. The mentioned blood pump contains a rotor rotating on a magnetic bearing without a shaft and through the helical wings placed into the rotor it provides pulsatile blood supply adequate for the body requirement synchronous with the ECG signals received from the patients. It provides a patient safer and controlled pulsatile blood flow while running at high efficiency. 1. A blood pump for providing pulsatile blood flow with cardiopulmonary by-pass devices and the supportive devices of circulation system , wherein the blood pump enables pulsatile blood flow by running systolic and diastolic intermittently like a healthy human heart , and comprises a pulsatile blood pump , a control unit and a checking pulsatile blood pump.2. The blood pump according to claim 1 , wherein the pulsatile blood pump further comprises a stator claim 1 , a hollow rotor rotating frictionlessly in a magnetic bearing in the stator and helical winglets fixed inside the rotor.3. The blood pump according to claim 1 , wherein the pulsatile blood pump further comprises a rotor claim 1 , a plurality of permanent neodymium magnet bars on the rotor claim 1 , a disposable biocompatible case with a plurality of beads claim 1 , wherein a plurality of permanent neodymium magnet rings on both sides of the rotor are placed in the case.4. The blood pump according to claim 1 , wherein the stator is made of overlapped siliceous sheet metal claim 1 , and contains a lot of cavities where a plurality of electric coils can be located.5. The blood pump according to claim 1 , wherein the rotor remains frictionlessly and rotates frictionlessly ...

COMBINED EXTRACORPOREAL AND DRUG DELIVERY SYSTEM AND METHOD

An extracorporeal and drug delivery system includes (i) a renal failure therapy machine operable with a blood filter in fluid communication with an arterial line and a venous line, the machine including (a) an effluent pump for pumping effluent from the blood filter at an effluent flowrate, and at least one of (b) a dialysis fluid pump for pumping dialysis fluid to the blood filter at a dialysis fluid flowrate, (c) a predilution pump for pumping replacement fluid into the arterial line at a predilution flowrate, or (d) a postdilution pump for pumping replacement fluid into the venous line at a postdilution flowrate; (ii) an infusion pump operable to deliver an intravenous (“IV”) drug to the patient at an IV drug flowrate; and (iii) a coordinating logic implementor configured to adjust the IV drug flowrate based on an amount of the IV drug removed via the effluent flowrate. 1. An extracorporeal and drug delivery system comprising: an effluent pump positioned and arranged to pump effluent from the blood filter at an effluent flowrate, and', a dialysis fluid pump positioned and arranged to pump dialysis fluid to the blood filter at a dialysis fluid flowrate,', 'a predilution pump positioned and arranged to pump replacement fluid into the arterial line at a predilution flowrate, or', 'a postdilution pump positioned and arranged to pump replacement fluid into the venous line at a postdilution flowrate;, 'at least one of'}], 'a renal failure therapy machine operable with a blood filter in fluid communication with an arterial line for removing blood from a patient to the blood filter and a venous line for returning blood from the filter to the patient, the renal failure therapy machine including'}an infusion pump operable to deliver an intravenous (“IV”) drug to the patient at an IV drug flowrate; anda coordinating logic implementor configured to determine an adjustment for the IV drug flowrate based on an amount of the IV drug removed via the effluent flowrate.2. The ...

FILTERING OF A TIME-DEPENDENT PRESSURE SIGNAL

A device removes first pulses in a pressure signal of a pressure sensor which is arranged in a fluid containing system to detect the first pulses, which originate from a first pulse generator, and second pulses, which originate from a second pulse generator. The first pulse generator operates in a sequence of pulse cycles, each pulse cycle resulting in at least one first pulse. The device repetitively obtains a current data sample, calculates a corresponding reference value and subtracts the reference value from the current data sample. The reference value is calculated as a function of other data sample(s) in the same pressure signal. The fluid containing system may include an extracorporeal blood flow circuit, e.g. as part of a dialysis machine, and a cardiovascular system of a human patient. 1. A device for processing a time-dependent pressure signal obtained from a pressure sensor in a fluid containing system associated with a first pulse generator and a second pulse generator , wherein the pressure sensor is arranged in the fluid containing system to detect first pulses originating from the first pulse generator and second pulses originating from the second pulse generator , wherein the first pulse generator operates in a sequence of pulse cycles , each pulse cycle resulting in at least one first pulse , said device comprising:an input for the pressure signal; and repetitively obtain a current data sample within a current pulse cycle in the pressure signal;', 'calculate, for each current data sample within the current pulse cycle, a reference value as a function of a cycle-synchronized data sample in one or more other pulse cycles in the pressure signal, the cycle-synchronized data sample being obtained to have a location in said one or more other pulse cycles that corresponds to a location of the current data sample in the current pulse cycle; and', 'operate a subtraction algorithm on the current data sample, using said reference value obtained for the current ...

BIDIRECTIONAL VASCULAR CANNULA DEVICE

A bidirectional vascular cannula device includes a tube and a moving mechanism having a through hole. The tube includes a tubular wall which defines therein a passage having opposite proximal and distal opened ends. The tubular wall has a secondary opening formed therethrough. Oxygenated blood infused into the passage from the proximal opened end is delivered to one end of the blood vessel from the distal opened end, and a part of the blood is delivered to the other end of the blood vessel through the secondary opening and the through hole so as to obviate ischemic caused by cannula occlusion. The moving mechanism is operable to be moved to permit a part of the moving mechanism to project outwardly and to be attached to the inner wall of the blood vessel for positioning the cannula device. 1. A bidirectional vascular cannula device comprising:a tube including a tubular wall which defines a passage therein, said passage having a proximal opened end and a distal opened end opposite to each other, said tubular wall having an outer wall surface, an inner wall surface radially opposite to said outer wall surface, and a secondary opening formed therethrough from said outer wall surface to said inner wall surface and in spatial communication with said passage; anda moving mechanism slidably embedded in said tubular wall between said outer wall surface and said inner wall surface, said moving mechanism having a through hole adjacent to said secondary opening, and being operable to move relative to said tubular wall between a first position, where said through hole is offset from said secondary opening and said moving mechanism blocks said secondary opening, and a second position, where said through hole is aligned and in spatial communication with said secondary opening and a part of said moving mechanism projects outwardly from said outer wall surface.2. The bidirectional vascular cannula device as claimed in claim 1 , wherein said tubular wall has a slit formed ...

BLOOD COLLECTION SYSTEM AND METHOD

A blood collection system comprises a suction unit (), a hose arrangement () connected to the suction unit, means for aspirating blood and air through the suction unit and for pumping said blood and air through the hose arrangement, a flow sensing unit () for continuously sensing the blood flow through the hose arrangement, an anticoagulant additive dosing system () for continuously dosing an anticoagulant additive into the blood flowed through the hose arrangement in response to the continuously sensed blood flow, a mixing unit () for mixing the blood with the anticoagulant additive dosed into the blood, and a collection vessel () for collecting the mixed blood and anticoagulant additive. The means for aspirating and pumping the blood and air is a pump system () providing a known constant volume flow of the blood and air in the hose arrangement, the flow sensing unit () is arranged for continuously sensing the mass flow of blood through the hose arrangement by means of continuously measuring a parameter indicative of the weight of blood in a tubing section (), through which the blood is transported, and the anticoagulant additive dosing system comprises a control unit () connected to the flow sensing unit and arranged for automatically controlling the continuously dosing of an anticoagulant additive into the blood flowed through the hose arrangement in response to the continuously sensed mass flow of blood. 1. A blood collection system comprising a suction unit; a hose arrangement connected to said suction unit; means for aspirating blood and air through the suction unit and for pumping said blood and air through the hose arrangement; a flow sensing unit for continuously sensing the blood flow through the hose arrangement; an anticoagulant additive dosing system for continuously dosing an anticoagulant additive into said blood flowed through the hose arrangement in response to the continuously sensed blood flow; a mixing unit for mixing the blood with the ...

Calculation of the patient fluid removal rate to compensate for the volume of fluid not removed because of machine down times

A patient fluid removal compensation volume may be determined to make up for the patient fluid removal that does not occur during machine down times, and the patient fluid removal rate may be increased until the compensating volume is satisfied.

AUTOMATED FLUID INFUSION CONTROL FOR CIRCULATORY SUPPORT AND ECMO SYSTEMS

The present disclosure provides systems for controlling infusion of one or more supplements into blood received from a patient. The systems may include at least one extracorporeal circulatory support system including a pump, fluid conduits, and at least one sensor configured to measure one or more parameters of the blood. The system also may include a fluid flow regulator coupled to the extracorporeal circulatory support system; and a processor, a memory, and associated circuitry communicatively coupled to the at least one sensor and the at least one fluid flow regulator. The system receives measurement signals corresponding to parameters of blood from the at least one sensor and determines one or more target values for the parameters of blood based on a patient profile and/or the measurements. The system may control the fluid flow regulator to cause an infusion of at least one supplemental fluid from a supplemental fluid source into the blood. 1. A system for controlling infusion of one or more supplements into blood received from a patient , the system comprising: a pump,', 'a plurality of fluid conduits fluidly coupled to the pump through which the blood flows, and', 'at least one sensor configured to measure one or more parameters of the blood;, 'at least one extracorporeal circulatory support system comprisingat least one fluid flow regulator coupled to the extracorporeal circulatory support system; and receive one or more signals corresponding to a measured value of the one or more parameters of blood from the at least one sensor,', 'determine one or more target values for the one or more parameters of blood received from the patient, based on a patient profile and the one or more signals, and', 'control the at least one fluid flow regulator to infuse at least one supplemental fluid from a supplemental fluid source into the blood to modify at least one of a content and a state of the blood, based on the one or more target values., 'a processor, a memory, and ...

Biological fluid flow control apparatus and method

Apparatus, system and method are provided for controlling flow through a biological fluid processing device. Pressure of fluid flow through a flow path is monitored and flow rate in the flow path is increased or decreased based on sensed pressure levels for selected periods of time. This has particular application in controlling flow in an infusion or return flow path of an apheresis device that separates whole blood into one or more blood components.

SYSTEMS AND METHODS FOR REAL TIME CALIBRATION OF PUMP STROKE VOLUMES DURING A BLOOD SEPARATION PROCEDURE

A method is provided for the real time calibration of a pump that is part of a reuseable hardware component having a programmable controller during a blood separation procedure where fluid is flowed through a tubing in a tubing set by action of the pump. The method comprises programming the controller with a continuous function defining a relationship between pump inlet pressure and pump stroke volume; commencing the fluid processing procedure to operate the pump to draw fluid through the tubing; measuring fluid pressure in the tubing at the inlet of the pump; calculating a current pump stroke volume with the controller based on the continuous function and the pump rotational rate; and adjusting the pump rotational rate utilized by the controller to control the procedure to achieve a target fluid flow rate. The continuous function defining the relationship between pump inlet pressure and the pump stroke volume may be empirically determined over a predetermined range of inlet pressures. 1. In a fluid processing procedure utilizing a tubing set comprising a tubing through which fluid is flowed and a reusable hardware component comprising at least one pump having a stroke volume , a rotational rate , and an inlet through which fluid is flowed by operation of the pump and a programmable controller for automatically performing the fluid processing procedure based at least in part on a fluid flow rate through the pump , the fluid flow rate being a product of the pump stroke volume and the pump rotational rate , a method for real time calibration of the pump stroke volume to achieve a target fluid flow rate comprising:a) programming the controller with a continuous function defining a relationship between pump inlet pressure and pump stroke volume;b) commencing the fluid processing procedure to operate the pump to draw fluid through the tubing;c) measuring fluid pressure in the tubing at the inlet of the pump;d) calculating a current pump stroke volume with the controller ...

Localized Therapy Delivery and Local Organ Protection

A system for perfusing a localized site within a body includes a catheter assembly having a venous access line that is adapted to deliver perfusate to the localized site, a venous or arterial drainage line adapted to drain perfusate from the localized site, and an occlusion device adapted to prevent some or substantially all physiological blood flow between the localized site and the systemic circulation of the body during and in the course of perfusing and draining perfusate to and from the localized site. The system may include a blood circuit associated with the catheter assembly to facilitate blood conditioning for use as the perfusate, in the course of a controlled perfusion and/or drainage of untreated, treated, or inactivated treated blood to and from the localized site. A delivery machine may control the blood circuit and catheter assembly in order to both deliver perfusate to, and drain some or all perfusate from, the localized site in a manner that provides perfusate to substantially only the localized site. 1. A system for delivering localized therapy to a tissue structure , said system comprising: (i) a venous perfusion line adapted to deliver perfusate to the tissue structure;', '(ii) a venous drainage line adapted to recover drainage flow from the tissue structure; and', '(iii) an occlusion device adapted to selectively substantially occlude venous blood flow between the tissue structure and systemic blood circulation;, 'a catheter apparatus comprisinga blood conditioning apparatus associated with said venous catheter apparatus for supplying perfusate to the tissue structure through said venous access line, and recovering the drainage flow from the tissue structure through said venous drainage line, said blood conditioning apparatus including a perfusion valve, a drainage valve, and a valve controller, wherein said valve controller is responsive to a signal from a sensor detecting one or more conditions of the tissue structure, the valve controller ...

EXTRACORPOREAL BLOOD TREATMENT MACHINE COMPRISING LEAKAGE DETECTION AND METHOD OF DETECTING LEAKAGES IN DIALYSIS FLUID SYSTEMS

The invention relates to an extracorporeal blood treatment machine, such as a dialysis machine, comprising leakage detection as well as to a method of detecting leakages in the dialysis fluid circuit of a dialysis machine, wherein at least part of the dialysis fluid system to be monitored in terms of leakage is accommodated in a hermetically sealed housing and the housing is or can be ventilated in a controlled manner, and wherein a parameter, such as the air humidity of the air flowing into the housing is compared to a corresponding parameter, preferably air humidity of the air flowing out of the housing. 112-. (canceled)13. Extracorporeal blood treatment machine comprising:a housing having at least one first ventilation aperture and at least one second ventilation aperture, wherein the housing with the exception of the ventilation apertures is configured to be hermetically sealed;a dialysis fluid system to be detected or to be monitored for leakage, wherein at least part of the dialysis fluid system is accommodated in the housing,at least one vent configured to convey ambient air from the at least one first ventilation aperture or the at least one second ventilation aperture through the housing to the other at least one ventilation aperture, andat least one measuring device configured to determine humidity of at least one of the ambient air flowing into the housing or the ambient air flowing out of the housing via the ventilation apertures.14. The extracorporeal blood treatment machine according to claim 13 , wherein the treatment machine is a dialysis machine.15. The extracorporeal blood treatment machine according to claim 13 , wherein the at least one vent is operable via a control at staggered intervals to convey the ambient air in two opposite directions through the housing.16. The extracorporeal blood treatment machine according to claim 13 , wherein the at least one measuring device comprises a first measuring means and a second measuring means and wherein ...

System and Method for Determining Irradiation Exposure Time with Irradiation Sensors During Extracorporeal Photopheresis

An irradiation device for photopheresis, comprising an exposure chamber configured to receive an illumination container holding a target cell suspension; an irradiation source configured to irradiate the illumination container and target cell suspension for a certain exposure time period; an irradiation sensor configured to detect the intensity of irradiation emitted by the irradiation source; and a processing circuit coupled to the irradiation sensor and configured to treat the target cell suspension with a predetermined treatment dosage of radiation, wherein the processing circuit adjusts the exposure time period based on the intensity of irradiation in order to achieve the predetermined treatment dosage. 1. An irradiation device for photopheresis , comprising:an exposure chamber configured to receive an illumination container holding a target cell suspension;an irradiation source configured to irradiate the illumination container and target cell suspension for a certain exposure time period;an irradiation sensor configured to detect the intensity of irradiation emitted by the irradiation source; anda processing circuit coupled to the irradiation sensor and configured to treat the target cell suspension with a predetermined treatment dosage of radiation, wherein the processing circuit adjusts the exposure time period based on the intensity of irradiation in order to achieve the predetermined treatment dosage.2. The irradiation device of claim 1 , wherein the target cells comprise mononuclear cells.3. The irradiation device of claim 1 , wherein the target cell suspension contains photoactivation agent 8-methoxypsoralen.4. The irradiation device of claim 1 , wherein the irradiation source emits UV-A light and the irradiation sensor senses UV-A light.5. The irradiation device of claim 1 , wherein the irradiation source comprises at least one of a light bulb and LED lighting.6. The irradiation device of claim 1 , wherein the irradiation sensor is disposed within the ...

Display Device and Display Method

A display apparatus for a user interface of a medical instrument avoids erroneous input of numerical values when a user inputs information. A display apparatus includes a numerical value information input section, a selectable target information display section, and a target selection section. A plurality of the setting information selection sections are displayed to be associated with corresponding selectable target information, and a plurality of pieces of selectable target information are arranged so as to be adjacent to each other based on a same standard. The numerical value information input section corresponding to the selected target selection section is displayed simultaneously on a same screen. A range of the selectable target information is changed visually and displayed in response to the numerical value information which is input to the numerical value information input section. 1. A display apparatus for a medical instrument monitoring various types of information and configured to accept user input for controlling operation of the medical instrument , the display apparatus comprising:a numerical value information input section through which numerical value information can be input;a selectable target information display section that displays a plurality of pieces of selectable target information; andtarget selection sections that are used to select any one of the plurality of pieces of selectable target information,wherein the plurality of target selection sections are displayed to be associated with the corresponding selectable target information,wherein the plurality of pieces of selectable target information are arranged so as to be adjacent to each other based on a same standard,wherein when any one of the plurality of target selection sections is selected, the numerical value information input section corresponding to the selected target selection section is displayed simultaneously on a same screen together with the selected selectable target ...

BLOOD PURIFICATION APPARATUS

The present teachings provide a blood purification apparatus including a drain-liquid temporary chamber that stores drain liquid drained from a blood purifier that purifies blood of a patient, a first drain-liquid drain line through which the drain liquid flows into the drain-liquid temporary chamber, a second drain-liquid drain line through which the drain liquid stored in the drain-liquid temporary chamber is drained to an outside of the apparatus, a draining unit provided to the second drain-liquid drain line and that drains the drain liquid stored in the drain-liquid temporary chamber to the outside of the apparatus, a remaining-amount-detecting unit that detects an amount of drain liquid remaining in the drain-liquid temporary chamber, a judging unit that judges whether or not a reference remaining amount is reached by the drain liquid in the drain-liquid temporary chamber from a result of detection by the remaining-amount-detecting unit, and a control unit that controls the draining unit. The control unit executes a draining process in which the draining unit is controlled such that the drain liquid in the drain-liquid temporary chamber is drained to the outside of the apparatus. The draining process is ended if it is judged by the judging unit that the reference remaining amount is reached by the drain liquid in the drain-liquid temporary chamber. 1. A blood purification apparatus comprising:a drain-liquid temporary chamber that stores drain liquid drained from a blood purifier that purifies blood of a patient;a first drain-liquid drain line through which the drain liquid flows into the drain-liquid temporary chamber;a second drain-liquid drain line through which the drain liquid stored in the drain-liquid temporary chamber is drained to an outside of the apparatus;a draining unit provided to the second drain-liquid drain line and that drains the drain liquid stored in the drain-liquid temporary chamber to the outside of the apparatus;a remaining-amount- ...

Medical fluid treatment machines and related systems and methods

A method comprising: receiving patient assessment information concerning one or more subjective characteristics of a patient; determining a patient assessment score based on the received patient assessment information; and modifying operation of a medical fluid treatment machine based on the patient assessment score.

EXTRACORPOREAL CIRCULATION DEVICE

An extracorporeal blood circulator includes a control unit and a speed manipulation section. A rotation display section displays a lower limit rotation setting value of a pump motor in accordance with a command of the control unit. The lower limit rotation speed setting value is a minimum rotation speed for preventing backflow of blood inside a circulation circuit A manually adjusted speed setting request from the manipulation section controls the pump speed, except that the controller enforces the lower limit speed setting unless receiving confirmation from a manipulator. 1. An extracorporeal circulator driven by a rotation drive unit to circulate blood of a patient outside a body , the extracorporeal circulator comprising:a control unit coupled to the rotation drive unit to control an actual rotation speed of the rotation drive unit;a manipulation section coupled to the control unit to manually adjust a speed setting request provided to the control unit, wherein the control unit controls the rotation speed of the rotation drive unit subject to a lower limit rotation speed setting value; anda rotation speed display section that displays the lower limit rotation setting value of the rotation drive unit in accordance with a command of the control unit,wherein the lower limit rotation speed setting value is a minimum rotation speed for preventing backflow of the blood inside the circulator so as to operate the rotation drive unit and to cause the blood to return to an inside of the body of the patient.2. The extracorporeal circulator according to claim 1 ,wherein after a rotation speed of the rotation drive unit is raised above the lower limit rotation speed setting value, the control unit causes the display section to display a confirmation message in response to a manually adjusted speed setting request at or below the lower limit rotation speed setting value.3. The extracorporeal circulator according to claim 2 ,wherein when the confirmation message displayed by ...

Device For An Extracorporeal Blood Treatment, And Method For Determining A Hemodynamic Parameter During An Extracorporeal Blood Treatment

The invention relates to a device for extracorporeal blood treatment, comprising a blood treatment unit that comprises at least one compartment . The invention further relates to a method for determining a hemodynamic parameter during an extracorporeal blood treatment by means of an extracorporeal blood treatment device. In order to determine the hemodynamic parameter, the conveying direction of the blood pump is reversed from a “normal” blood flow to a “reversed” blood flow. In practice, it has been found that reversing the conveying direction of the blood pump for a measurement for determining a hemodynamic parameter carries the risk of blood clots reaching the patient, despite the dialyser holding back blood clots. The blood treatment device comprises an input unit for inputting a time interval which can be specified by the user, taking into account the patient-specific and system-specific factors. The control and evaluation unit of the blood treatment device is configured such that the operation of the blood pump in the operating mode involving a reversed blood flow is only enabled during the time interval input by means of the input unit, the start of the time interval being determined from the point at which the blood treatment starts. 1. Device for extracorporeal blood treatment , comprising a blood treatment unit comprising at least one compartment , a first blood line which is connected to a connection of the compartment and comprises a first patient connection , a second blood line which is connected to a connection of the compartment and comprises a second patient connection , a blood pump for conveying blood , an apparatus for measuring a physical or chemical characteristic variable , a control and evaluation unit which is connected to the blood pump and to the apparatus for measuring a physical or chemical characteristic variable and is configured such that , for one measurement cycle of two measurement cycles , the blood pump is operated in an ...

MONITORING SYSTEM FOR CARE PROTOCOLS

A monitoring system for care protocols, comprising sensors connected to electronic devices to input data from a patient, where sensors measure critical values from a patient; an interface for receiving data and allowing users to write and change process control in real time; a processor connected to the interface to receive input parameters, wherein the processor calculates output values based on the input parameters compared to the critical value to determine whether the output values are outside acceptable range; means for setting critical values, ranges of critical value, and alarm points when the critical values are outside of the range; where the interface receives critical patient parameters and the interface includes a manual input and a machine input from one or more sensors; and wherein the system calculates and monitors critical steps or values for a patient and enables the output values for monitoring or display, in real time. 1. A monitoring system for care protocols , wherein the system comprises:a plurality of sensors operably connected to electronic devices to input data from a patient to an interface, said sensors being disposed to measure critical values from a patient;an interface for receiving input data and allowing users to define process control limits and when appropriate change these limits of a process control in real time, as appropriate for the care of the specific patient;a means for authorized practitioners to formally document the decision to deviate from a medical facility defined protocol or the specific patient care plan;a processor operably connected to the interface to date stamp and receive, agnostically, data signals corresponding to received data input pertaining to one or more input parameters, wherein specific data values collected from the multiple data sources may be used in more than one output calculation formula, the processor calculates one or more output values based on the one or more input parameters and compares said ...

Apparatus and a method for extracorporeal blood treatment

An apparatus for extracorporeal blood treatment comprises a sensor ( 10 ) for emitting a signal indicating a variation in blood volume (ΔBv″) of an individual ( 7 ) subjected to extracorporeal blood treatment and a sensor ( 14 ) for emitting a signal indicating a weight loss of the individual. A control unit ( 20 ) receives the signals, compares the ratio between the relative variation of blood volume (ΔBv/BV) and the relative variation of weight loss (AWL/TW) of the individual with a desired value, and controls the weight loss of the individual on the basis of the comparison. The apparatus enables automatically controlling a dialysis, preventing some complications due to hypotension.

DIALYSIS APPARATUS WITH VERSATILE USER INTERFACE AND METHOD AND COMPUTER PROGRAM THEREFOR

An apparatus, method and computer program for performing a plurality of operation steps of a dialysis process is disclosed. In one embodiment, a process controller controls the apparatus to perform the operation steps, monitor the dialysis process and monitor sensor inputs of sensors of the apparatus. The apparatus further includes a user interface (“UI”), comprising a display, an input device and a UI controller, wherein the UI controller enables presentation of graphical data on the display, enables user interaction with the graphical data and exchanges information with the process controller. Each of the operation steps is classified as a sequential operation step or a non-sequential operation step. The UI controller, for each of the operation steps, dynamically controls enabling and disabling of interaction with displayed corresponding operation step items based on a state of the respective operation step (i.e., completed, non-completed, selectable, non-selectable). 1. An apparatus for performing a plurality of operation steps of a dialysis process , said apparatus comprising:a process controller for controlling the apparatus to perform the operation steps of the dialysis process, monitor process progress of the dialysis process and monitor sensor inputs of sensors of the apparatus; anda user interface comprising a display, an input device and a user interface controller, wherein the user interface controller is connected to enable presentation of graphical data on the display, and wherein the user interface controller is connected to enable user interaction with the graphical data and connected to exchange information with the process controller, wherein the exchanged information is based on the user interaction of the user interface and monitoring of process progress of the dialysis process and sensor inputs of sensors of the apparatus monitored by the process controller, and whereineach of the operation steps are classified in the user interface controller as ...

DUAL CHAMBER GAS EXCHANGER AND METHOD OF USE FOR RESPIRATORY SUPPORT

The device of the present invention includes a dual chamber gas exchanger that is configured for increased flexibility and scalability for many clinical applications. The dual chamber oxygenator can be configured and used in various applications, such as in a heart-lung machine for cardiopulmonary support during cardiothoracic surgery, in an extracorporeal membrane oxygenation (ECMO) circuitry, as a respiratory assist device for patients with lung failure, and the like. The dual chamber gas exchanger features two sweep gas flow paths and two gas exchange membrane bundles enclosed in a housing structure with various blood flow distribution and gas distribution mechanisms. The gas exchanger includes an outer housing, an intermediate housing, two gas exchange fiber bundles, a blood inlet, a blood outlet, two gas inlets, two gas outlets, two gas distribution chambers and an optional heat exchanger. 1. A blood oxygenator comprising:a housing comprising a blood inlet, a blood outlet, a stripping gas inlet, an oxygenation gas inlet, and at least one gas outlet; andan oxygenator fiber bundle disposed within the housing and configured so that blood flows through a blood flow region in the oxygenator fiber bundle in a predetermined path from the blood inlet to the blood outlet;wherein the stripping gas inlet is configured to direct a flow of stripping gas through a stripping region of the oxygenator fiber bundle to the at least one gas outlet and the oxygenation gas inlet is configured to direct a flow of oxygenation gas through an oxygenation region of the oxygenator fiber bundle to the at least one gas outlet; andwherein the stripping gas region of the oxygenator fiber bundle is upstream of the oxygenation region of the oxygenator fiber bundle.2. The blood oxygenator of claim 1 , wherein the fiber bundle is cylindrical and at least a portion of the blood flow path is radially inward or radially outward.3. The blood oxygenator of claim 1 , wherein the fiber bundle is ...

Blood Purification Apparatus and Method of Discharging Bubbles Therefrom

Microbubbles detached from a blood circuit and a blood purification unit are discharged with the use of a backflow generated at the instant that a roller of a blood pump releases a squeezable tube. In a normal rotation step, a region filled with a priming solution after a priming step is closed by a closing unit, and a rotor of a blood pump is rotated normally until a roller of the blood pump releases a squeezable tube to generate a backflow. After the backflow is generated at the release of the squeezable tube by the roller of the blood pump, bubbles are moved by reversely rotating the rotor while disabling the closing by the closing unit. Thus, the bubbles are discharged through a discharge unit. 1. A blood purification apparatus comprising:a blood circuit including an arterial blood circuit and a venous blood circuit and allowing a patient's blood to extracorporeally circulate from a distal end of the arterial blood circuit to a distal end of the venous blood circuit;a blood purification unit connected to a proximal end of the arterial blood circuit and to a proximal end of the venous blood circuit and that purifies the blood flowing through the blood circuit;a squeezable tube connected to the arterial blood circuit;a blood pump formed of a peristaltic pump that delivers liquid by squeezing, with a roller, the squeezable tube while a rotor is driven to rotate, the blood pump delivering the liquid from the distal end of the arterial blood circuit toward the blood purification unit when the rotor is rotated normally such that the roller moves in a lengthwise direction of the squeezable tube, the blood pump delivering the liquid from the blood purification unit toward the distal end of the arterial blood circuit when the rotor is rotated reversely such that the roller moves in the lengthwise direction of the squeezable tube;a discharge unit through which a priming solution supplied into the blood circuit is discharged to an outside;a closing unit that generates a ...

Systems And Methods For Treating Blood

According to some embodiments, a system may treat blood outside the body of a patient. The system may include one or more pumps configured to draw blood from a patient into a fluid flow path at a rate, for example, of 5-7 liters per minute. The system may include one or more heat exchangers coupled to the fluid flow path and configured to heat the blood, for example, to a temperature above 42 degrees Celsius and below 43.2 degrees Celsius.

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND A CONTROL METHOD THEREFOR

An apparatus is described for extracorporeal blood treatment (), comprising a treatment unit (), an extracorporeal blood circuit () and a fluid evacuation line (). The apparatus comprises a control unit () connected with a pressure sensor () and with a blood pump () and configured to move the blood pump (), generating a variable flow with a constant component equal to a desired blood flow value and a variable component having a nil mean value; the variable flow generates, in the expansion chamber (), a progression of the pressure that is variable over time (P(t)) with a pressure component (ΔP) oscillating about a mean value (P). The control unit receives, from the sensor, a plurality of values (P) over a period of time (T) comprising a plurality of oscillations of the pressure about the mean value and calculates, according to the pressure values (P), a control value that is representative of the oscillating pressure component (ΔP) and then compares the control value with a reference threshold to determine the verification or not of a condition of variation of the blood level in the expansion chamber (). 115-. (canceled)16. An apparatus for extracorporeal blood treatment comprising:at least a treatment unit having at least a first chamber and at least a second chamber separated from one another by a semipermeable membrane;at least a blood removal line connected to an inlet port of a first chamber and predisposed to remove blood from a patient;at least a blood return line connected to an outlet port from the first chamber and predisposed to return treated blood to the patient;at least an expansion chamber placed at least in one of the blood removal line and the blood return line, the expansion chamber being arranged in use to contain a predetermined quantity of gas in an upper portion and a predetermined quantity of blood at a predetermined level in a lower portion, the blood removal line, the blood return line, the first chamber and the at least an expansion chamber ...

Method as Well as Apparatuses for Testing at Least One Function of A Medical Functional Device

The invention relates to a method for testing at least one function of a medical functional device which is inserted in and connected and compressed with a medical treatment apparatus, and/or a function of this treatment apparatus, wherein between a hydraulic device or a pneumatic unit of the treatment apparatus and the functional device at least one fluid communication is established. It further relates to a detection device which is programmed and/or configured for executing the method according to the invention as well as a medical treatment apparatus which comprises at least one detection device and/or is in signal transmission or is connected for signal transmission with it, a digital storage medium, a computer program product as well as a computer program.

Control Apparatus For Blood Treatment Apparatus, And Blood Treatment Apparatus

The present disclosure relates to a control apparatus, configured to control or regulate a blood treatment apparatus when the latter is connected in signal communication with the control apparatus for a blood treatment that already has been performed or is to be performed. The control apparatus includes at least a switch with a switching section and a signal processing unit. The signal processing unit is configured to receive signals from the foot switch and configured to emit signals to components of the blood treatment apparatus to control or regulate the blood treatment apparatus. 119-. (canceled)20. A control apparatus , configured to control or regulate a blood treatment apparatus when in signal connection with the blood treatment apparatus , the control apparatus comprising:a foot switch having at least one switching section; anda signal processing unit configured to receive signals from the foot switch and configured to emit signals to components of the blood treatment apparatus to control or regulate the blood treatment apparatus.21. The control apparatus according to claim 20 , wherein the switching section is or comprises a touch switch claim 20 , wherein the touch switch is configured to be actuated by a user.22. The control apparatus according to claim 21 , wherein the touch switch has at least two switch positions or at least two switching areas for emitting different switching signals to the signal processing unit.23. The control apparatus according to claim 20 , wherein the switching section is or comprises a touchless switch.24. The control apparatus according to claim 23 , wherein the touchless switch is an optical or inductive switch.25. The control apparatus according to claim 23 , wherein the touchless switching section and/or the signal processing unit are configured to translate gestures into signals; and wherein the processing unit is configured to control or regulate the blood treatment apparatus based on the signals.26. The control apparatus ...

System and method for detecting venous needle dislodgement

Systems and methods are disclosed for detecting an interruption of connection between a blood treatment apparatus and a patient blood circulation. The system includes a line shut-off for blocking the venous fluid line arranged between the blood treatment apparatus and a connector, an arterial fluid line arranged between the blood treatment apparatus and the patient blood circulation, a pressure sensor arranged in the venous fluid line or the arterial fluid line for measuring pressure, and a control and evaluation unit for evaluating a pressure curve in time of the pressure measured by the pressure sensor during blocking of the venous fluid line to detect an interruption or disturbance of the connection between the first connection means and the patient blood circulation.

METHOD FOR ASSESSING A PATIENT'S FLUID STATUS AND/OR SENSITIVITY TO FLUID REMOVAL, CONTROLLER, AND DEVICES

The present invention relates to a method for assessing a patient's sensitivity to fluid removal from the patient's vascular system or to fluid replacement or addition with regard to the patient's hydration state, the method comprising the step of determining a value reflecting the distribution of fluid between at least two distribution spaces of the body of the patient or changes thereof from measured or calculated values, and assessing whether the value fulfils at least one criterion. It also relates to a controller, an apparatus, a device, a digital storage device, a computer program product, and a computer program. 126-. (canceled)27. A blood treatment system for treating the blood of a patient , comprising:an obtaining system for obtaining a first value reflecting the distribution of fluid between at least a first and a second distribution space of the patient; and,a control system,wherein the control system determines whether said first value fulfils at least one criterion, the criterion being a saturation degree of at least one of the distribution spaces, the saturation degree being a ratio between the changes of the two distribution spaces over time.28. The blood treatment system according to claim 27 , wherein the blood treatment system is configured to treat a patient by dialysis.29. The blood treatment system according to claim 28 , wherein the blood treatment system is configured to treat a patient or the patient's extracorporeally flowing blood by hemofiltration claim 28 , ultrafiltration claim 28 , and/or hemodialysis.30. The blood treatment system according to claim 27 , wherein the first or the second distribution space is selected from the group consisting of: the blood volume claim 27 , the extracellular fluid volume claim 27 , and the interstitium.31. The blood treatment system according to claim 27 , wherein the control system is configured to determine a saturation degree of at least one distribution space of the patient as said first value.32. ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. A system for regulating balanced flow of fluids , comprising:a fluid circuit with first and second fluid channels connectable to a fluid handling device, each with at least one respective pump for each of said first and second fluid channels, a controller connected to the respective pumps to control a rate of pumping of one or more of said respective pumps, the controller being connected to one or more valves to permit it to establish flows in the first and second channels;a ratio of flow rates of entering and leaving flows to and from the fluid handling device is controlled by said controller to effect a predefined net transfer of fluid to or from the fluid handling device responsively to calibration data accessible to said controller;the controller, at selected times, temporarily establishing one or more calibration flow paths in said fluid circuit, the calibration flow paths communicating respectively with ones of said first and second fluid channels to cause flow through a flow measurement component that generates a signal indicating a flow rate or relative flow rate generated by said respective pumps;the controller sampling the signal and in response to resulting samples, the controller adjusting said calibration data;the controller, using the adjusted calibration data stored in said controller to adjust the one or more of said respective pumps in order to effect said predefined net transfer of fluid to or from the fluid handling device;the selected times being determined by the controller responsively to detection ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described.

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. A medical treatment method , comprising:at treatment times, using peristaltic pumps, flowing medicament into and out of inflow and outflow channels connectable to a patient or treatment device;at calibration times, over a calibration interval of less than a minute, flowing medicament directly between the inflow and outflow channels such that pulsations generated by the peristaltic pumps cause pressure in a bridge channel between the inflow and outflow channels to fluctuate due to a superposition of a suction side pulsation and a pressure side pulsation of respective ones of said peristaltic pumps; andusing an adjustable flow restrictor, selecting a suction head of at least one of the respective ones of the peristaltic pumps so as to change a pulsation frequency thereof so that it differs from that of the other of the ones of the peristaltic pumps by a predetermined amount.2. The method of claim 1 , wherein the predetermined amount is such that a ratio of an inverse of a difference between pulsation frequencies of the ones of the peristaltic pumps is multiple times the calibration interval.3. The method of claim 1 , wherein the predetermined amount is such that a ratio of an inverse of a difference between pulsation frequencies of the ones of the peristaltic pumps is three times the calibration interval.4. The method of claim 1 , wherein the predetermined amount is such that a ratio of an inverse of a difference between pulsation frequencies of the ones of the peristaltic pumps is five times the calibration interval.5. The ...

EXTRACORPOREAL LIFE SUPPORT SYSTEM

The present invention provides a method, system, and apparatus that can substantially reduce the recirculation of venovenous extracorporeal membrane oxygenation (VV ECMO) associated with the two-site, single-lumen cannulation approach. Actively-controlled flow regulators comprising balloon, occluder and reservoir can be individually or collectively equipped on the drainage and/or infusion cannulas to accomplish the goal of maximizing VV ECMO support efficacy. Three specific embodiments are introduced to illustrate the practical enforcement of the proposed blood flow control in reference to the heart rhythm, aiming at achieving the maximal reduction of oxygenated blood flow recirculating back to the VV ECMO circuit. 1. An extracorporeal life support system comprising:a blood pump and an oxygenator disposed outside a patient's body;a drainage cannula assembly disposed in superior vena cava or inferior vena cava to receive deoxygenated blood, comprising at least one of a drainage balloon, a drainage occluder and a drainage reservoir that are employed and actuated in accordance with the patient's heart rhythm, wherein the drainage balloon is inflated or deflated to control venous return blood flow, the drainage occluder is compressed or relaxed to control blood drainage into the extracorporeal life support system, and the drainage reservoir is actuated together with the drainage occluder to result in a continuous blood pump flow; andan infusion cannula assembly disposed opposite to the drainage cannula assembly in either the superior vena cava or the inferior vena cava, the infusion cannula assembly being employed to deliver oxygenated blood flow back to the patient's circulation.2. The extracorporeal life support system as claimed in claim 1 , wherein the drainage cannula assembly comprises two fluid passages claim 1 , one fluid passage is able to transmit blood claim 1 , another fluid passage is connected to the drainage balloon to drive the drainage balloon inflation ...

INTRADIALYTIC MONITORING OF HEMODYNAMIC STATUS BASED ON DETECTION OF OXYGEN SIGNATURE PHASE SHIFT

A hemodialysis system includes: a hemodialysis machine configured to provide hemodialysis treatment to a patient, wherein the hemodialysis treatment includes circulating extracorporeal blood of the patient through an extracorporeal blood circuit; a first oxygen saturation sensor device configured to measure oxygen saturation corresponding to the extracorporeal blood of the patient in the extracorporeal blood circuit; a second oxygen saturation sensor device configured to measure oxygen saturation corresponding to blood flowing within the patient; and at least one controller configured to determine one or more oxygen saturation phase shift (OSPS) values or one or more transcutaneous travel time values corresponding to the patient based on oxygen saturation measurements from the first oxygen saturation sensor device and the second oxygen saturation sensor device. 1. A hemodialysis system , comprising:a hemodialysis machine configured to provide hemodialysis treatment to a patient, wherein the hemodialysis treatment includes circulating extracorporeal blood of the patient through an extracorporeal blood circuit;a first oxygen saturation sensor device configured to measure oxygen saturation corresponding to the extracorporeal blood of the patient in the extracorporeal blood circuit;a second oxygen saturation sensor device configured to measure oxygen saturation corresponding to blood flowing within the patient; andat least one controller configured to determine one or more oxygen saturation phase shift (OSPS) values or one or more transcutaneous travel time values corresponding to the patient based on oxygen saturation measurements from the first oxygen saturation sensor device and the second oxygen saturation sensor device.2. The hemodialysis system according to claim 1 , wherein the extracorporeal blood of the patient is drawn from the patient from an access site claim 1 , and wherein the second oxygen saturation sensor device is located on the patient ipsilateral to ...

PRESSURE SENSING EXTRACORPOREAL CIRCULATION DEVICE

An extracorporeal blood circulation system reduces the risk of generation of air bubbles entering the circulation circuit associated with placement of a pressure sensor that detects a patient's blood pressure at a blood removal line. Instead of directly measuring pressure at the blood removal line where suction exists, an intermediate part pressure sensor detects pressure between a centrifugal pump and an oxygenator. A controller identifies a discharge pressure specific to the centrifugal pump based on a rotation speed of the pump and a blood flow rate. The discharge pressure and the intermediate pressure values are combined to estimate the pressure at the blood removal line. 1. An extracorporeal circulation system comprising:a blood removal line to withdraw blood from inside a body of a subject;a centrifugal pump connected downstream of the blood removal line;an oxygenator connected downstream relative to the centrifugal pump via an intermediate tube;a blood sending line downstream relative to the oxygenator to return blood to the body;a flow rate sensor to detect a blood flow rate in the blood sending line;an intermediate part pressure sensor to detect pressure in the intermediate tube between the centrifugal pump and the oxygenator; anda discharge pressure identifying unit that identifies discharge pressure specific to the centrifugal pump based on rotation speed of the centrifugal pump and the blood flow rate detected in the flow rate sensor.2. The extracorporeal circulation system according to claim 1 , further comprising:a blood removal pressure calculating unit that subtracts the discharge pressure identified in the discharge pressure identifying unit from the pressure measured by the intermediate part pressure sensor to estimate pressure in the blood removal line.3. The extracorporeal circulation system according to claim 2 , further comprising:a blood removal state determining unit that determines whether or not the pressure calculated in the blood removal ...

Blood treatment and electrical blood leak detection device therefore

A blood treatment machine includes a blood pump; an arterial line in fluid communication with the blood pump, the arterial line including an arterial needle; a venous line including a venous needle; and a blood leak detection device including (i) at least one electrical component, (ii) a member configured to secure the at least one electrical component onto a patient's arm adjacent to patient access of at least one of the arterial and venous needles, the at least one electrical component capable of sensing the presence of a blood leak, and (iii) a controller in operable communication with the at least one electrical component, the controller programmed to allow for an amount of expected blood seepage and to cause an alarm if blood greater than the amount of expected blood seepage is sensed by the at least one electrical component.

Method as Well as Apparatuses for Testing at Least One Function of A Medical Functional Device

The invention relates to a method for testing at least one function of a medical functional device which is inserted in and connected and compressed with a medical treatment apparatus, and/or a function of this treatment apparatus, wherein between a hydraulic device or a pneumatic unit of the treatment apparatus and the functional device at least one fluid communication is established. It further relates to a detection device which is programmed and/or configured for executing the method according to the invention as well as a medical treatment apparatus which comprises at least one detection device and/or is in signal transmission or is connected for signal transmission with it, a digital storage medium, a computer program product as well as a computer program.

HLM PUMP STOP REACTION

A heart lung machine (HLM) includes: a pump actuator; an actuator control unit (ACU) operably connected to the pump actuator; a processing unit configured to receive a set of parameter data from the actuator; a display device configured to present a subset of the set of parameter data; and an input control device operably connected to the pump actuator. The input control device includes a rotatable knob. The ACU may be configured to: determine that the pump actuator has been stopped in response to a pump-stop trigger event; determine that the rotatable knob has been rotated to a first position; and in response to determining that the rotatable knob has been rotated to the first position, starting the pump actuator. 1. A heart lung machine (HLM) , comprising:a pump actuator;an actuator control unit (ACU) operably connected to the pump actuator;a processing unit configured to receive a set of parameter data from the actuator;a display device configured to present a subset of the set of parameter data; andan input control device operably connected to the pump actuator, the input control device comprising a rotatable knob, wherein the ACU is configured to:determine that the pump actuator has been stopped in response to a pump-stop trigger event;determine that the rotatable knob has been rotated to a first position; andin response to determining that the rotatable knob has been rotated to the first position, starting the pump actuator.2. The HLM of claim 1 , wherein the ACU is configured to start the pump actuatory without any interaction claim 1 , by a user claim 1 , with the display device.3. The HLM of claim 1 , wherein the first position corresponds to an initial activation condition with zero flow.4. The HLM of claim 1 , wherein the ACU is configured to:determine that the rotatable knob has been rotated to a second position, wherein the second position corresponds to a positive flow speed; andcause, in response to determining that the rotatable knob has been rotated ...

Localized Therapy Delivery and Local Organ Protection

A system for perfusing a localized site within a body includes a catheter assembly having a venous access line that is adapted to deliver perfusate to the localized site, a venous or arterial drainage line adapted to drain perfusate from the localized site, and an occlusion device adapted to prevent some or substantially all physiological blood flow between the localized site and the systemic circulation of the body during and in the course of perfusing and draining perfusate to and from the localized site. The system may include a blood circuit associated with the catheter assembly to facilitate blood conditioning for use as the perfusate, in the course of a controlled perfusion and/or drainage of untreated, treated, or inactivated treated blood to and from the localized site. A delivery machine may control the blood circuit and catheter assembly in order to both deliver perfusate to, and drain some or all perfusate from, the localized site in a manner that provides perfusate to substantially only the localized site. 1. A system for delivering therapy to a tissue structure , said system comprising: (i) an occlusion device adapted to selectively substantially occlude a venous drainage structure of said tissue structure so as to selectively define a tissue structure circulatory compartment distinct from a systematic circulatory compartment;', '(ii) a perfusion line adapted to deliver perfusate to the tissue structure circulatory compartment through a perfusion port;', '(iii) a drainage line adapted to recover drainage flow from the tissue structure circulatory compartment through a drainage port;', '(iv) a systematic port opening to the systematic circulatory compartment;, '(a) a catheter apparatus having one or more catheters, said catheter apparatus including(b) a blood conditioning apparatus for supplying conditioned blood to said tissue structure through said perfusion line, and fluidically coupling said perfusion line to said systemic port.2. The system as in ...

TARGET VOLUME BASED DIAPHRAGM REPOSITIONING FOR PRESSURE MEASUREMENT APPARATUS

Methods and extracorporeal blood treatment systems reposition a diaphragm of a pressure measurement apparatus (e.g., a pressure pod apparatus of an extracorporeal blood set) by, for example, controlling an air pump apparatus to move the diaphragm toward a target measuring position based on a calculated target air volume (e.g., wherein the calculated target air volume is representative of the air volume necessary to move the diaphragm to the target measuring position based at least on a monitored air pressure). For example, after the diaphragm is bottomed out or topped out, as air is added to or removed from the transducer side cavity of a pressure pod apparatus, the target air volume may be iteratively calculated until it is determined that the diaphragm is repositioned in the target measuring position. 1. An extracorporeal blood treatment system comprising: at least a pod body portion and a base body portion; and', 'a diaphragm separating a fluid side cavity defined at least in part by the pod body portion from a transducer side cavity defined at least in part by the base body portion, wherein the fluid side cavity is in fluid communication with an inlet and an outlet, and further wherein the diaphragm is displaceable from a target measuring position into the fluid side cavity towards the pod body portion and is displaceable from the target measuring position into the transducer side cavity towards the base body portion;, 'a pressure measurement apparatus comprisingan air pump apparatus coupled to the transducer side cavity via one or more connection elements to add air to or remove air from the transducer side cavity;at least one pressure transducer operatively coupled to the transducer side cavity to sense air pressure therein; control the air pump apparatus to bottom out the diaphragm on the base body portion by removing air from the transducer side cavity and/or to top out the diaphragm on the pod body portion by adding air to the transducer side cavity;', ' ...

Flow Balancing Devices, Methods, and Systems

The disclosed subject matter relates to extracorporeal blood processing or other processing of fluids. Volumetric fluid balance, a required element of many such processes, may be achieved with multiple pumps or other proportioning or balancing devices which are to some extent independent of each other. This need may arise in treatments that involve multiple fluids. Safe and secure mechanisms to ensure fluid balance in such systems are described. 1. A medical treatment system , comprising:a first fluid management element that pumps fluid from a patient interface device during a treatment;a second fluid management element that pumps fluid into a patient interface device during a treatment;the patient interface device being a device that interfaces with a patient fluidcompartment including at least one of a dialyzer, a hemofilter, a hemodiafilter, an ultrafilter, and a plasmapheresis device;a controller connected to at least one of the first and second fluid management elements and having a processor programmed to regulate a net transfer of fluid into or from the patient interface device to achieve a predefined net removal of fluid from the patient during a therapeutic treatment implemented under control of the controller;a fluid circuit switch that allows a flow from at least one of the first and second fluid management elements to be selectively and automatically configured under control of the controller between a therapy configuration for delivering said therapeutic treatment to a calibration configuration in which flow through said at least one of the first and second fluid management elements is temporarily diverted to a flow or pressure sensor that outputs a signal indicating a difference between the flow rates of the first and second fluid management elements;the controller being programmed to calculate and store flow correction data representing a correction to be applied to a rate of flow of said at least one of the first and second fluid management elements ...

Blood circuit assembly for a hemodialysis system

A blood circuit assembly for a dialysis unit may include an organizing tray, a pair of pneumatic pumps mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit, a pair of dialyzer connections arranged to connect to the inlet and outlet of a dialyzer unit, and a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient.

BIOLOGICAL COMPONENT TREATMENT CASSETTE AND BIOLOGICAL COMPONENT TREATMENT SYSTEM

A biological component treatment cassette (blood component collection cassette ()) is configured to be attachable to a separation device (centrifugal separation device ()) adapted to separate a biological component from a liquid containing at least one biological component, and a flow path () is formed in an interior portion thereof. The biological component treatment cassette includes a sheet-shaped cassette main body (), and a first pump action tube (), both ends of which are connected to the flow path () of the cassette main body (), together with a portion thereof protruding from an outer peripheral edge portion of the cassette main body (), and which is made from a soft material that is pressed by a pump () of a separation device. 1. A biological component treatment cassette configured to be attachable to a separation device adapted to separate a biological component from a liquid containing at least one biological component , and having a flow path formed in an interior portion thereof , the biological component treatment cassette comprising:a cassette main body formed from a flexible upper sheet and a flexible lower sheet between which there is formed a flow path wall configured to form the flow path in an interior portion thereof, said cassette main body having a flexible peripheral edge portion; anda pump action tube, both ends of which are connected to the flow path of the cassette main body, together with a portion thereof protruding from said outer peripheral edge portion of the cassette main body, and which is made from a soft material that is pressed by a pump installed in the separation device in order to cause a fluid to flow inside the flow path.2. The biological component treatment cassette according to claim 1 , wherein a measured portion is formed on the flow path wall.3. The biological component treatment cassette according to claim 2 , wherein the measured portion is configured in a manner so as to be pressed by the load detecting unit.4. The ...

Biological component collection system and flow path internal pressure acquisition method

A blood component collection system ( 10 ) includes a first internal pressure calculation unit ( 110 ) adapted to calculate a first internal pressure of a first pressed portion ( 60 ) using first calibration curve data ( 118 ), a second internal pressure calculation unit ( 112 ) adapted to calculate a second internal pressure of a second pressed portion ( 62 ) using second calibration curve data ( 120 ), and a correction unit ( 114 ) adapted to correct the first calibration curve data ( 118 ) in a manner so that, during a blood returning operation, the first internal pressure calculated by the first internal pressure calculation unit ( 110 ) becomes equal to the second internal pressure calculated by the second internal pressure calculation unit ( 112 ).

APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT AND A CONTROL METHOD THEREFOR

An apparatus is described for extracorporeal blood treatment, comprising a treatment unit, an extracorporeal blood circuit and a fluid evacuation line. The apparatus comprises a control unit connected to a pressure sensor and configured to move a blood pump, generating a variable flow with a constant component equal to a desired blood flow value and a variable component having a nil mean value; the variable flow generates, in the expansion chamber, a pressure progression that is variable over time with a pressure component oscillating about a mean value. The control unit receives a plurality of values over a period of time comprising a plurality of oscillations of the pressure about the mean value, calculates a control value representative of the oscillating pressure component, and then determines the verification or not of a condition of variation of the blood level in the expansion chamber. 115-. (canceled)16. A method for reducing the risk of infusion of gas microbubbles in a patient , the method comprising:moving a first actuator to generate a variable flow comprising a constant flow component of a desired flow value and a variable flow component oscillating about the constant flow component, the variable flow component having a substantially nil average value, the variable flow component generating in an expansion chamber a pressure progression that is variable in time, the pressure progression comprising a pressure component oscillating about a mean value;receiving from at least one sensor associated with the expansion chamber and configured to sense pressure values internally of the expansion chamber, a plurality of pressure values for a time period comprising a plurality of pressure oscillations about the mean value, the pressure values being measured at successive time instants;calculating, as a function of the pressure values, a control value that is representative of the oscillating pressure component;comparing the control value representing the ...

METHOD FOR ASSESSING A PATIENT'S FLUID STATUS AND/OR SENSITIVITY TO FLUID REMOVAL, CONTROLLER, AND DEVICES

The present invention relates to a method for assessing a patient's sensitivity to fluid removal from the patient's vascular system or to fluid replacement or addition with regard to the patient's hydration state, the method comprising the step of determining a value reflecting the distribution of fluid between at least two distribution spaces of the body of the patient or changes thereof from measured or calculated values, and assessing whether the value fulfils at least one criterion. It also relates to a controller, an apparatus, a device, a digital storage device, a computer program product, and a computer program. 126-. (canceled)27. A blood treatment system for treating the blood of a patient , comprising:an obtaining system for obtaining a first value reflecting the distribution of fluid between at least a first and a second distribution space of the patient; and,a control system,wherein the control system determines whether said first value fulfils at least one criterion, the criterion being a saturation degree of at least one of the distribution spaces, the saturation degree being a ratio between the changes of the two distribution spaces over time.28. The blood treatment system according to claim 27 , wherein the blood treatment system is configured to treat a patient by dialysis.29. The blood treatment system according to claim 28 , wherein the blood treatment system is configured to treat a patient or the patient's extracorporeally flowing blood by hemofiltration claim 28 , ultrafiltration claim 28 , and/or hemodialysis.30. The blood treatment system according to claim 27 , wherein the first or the second distribution space is selected from the group consisting of: the blood volume claim 27 , the extracellular fluid volume claim 27 , and the interstitium.31. The blood treatment system according to claim 27 , wherein the control system is configured to determine a saturation degree of at least one distribution space of the patient as said first value.32. ...

APPARATUS FOR EXTRACORPOREAL TREATMENT OF BLOOD INCLUDING CALCULATION OF FLOW RATES THEREFORE

An apparatus for extracorporeal treatment of fluid and a process of setting up a medical apparatus for the delivery or collection of fluids are disclosed. According to the apparatus and the process, a control unit () is configured calculate set values of two or more of the fluid flow rates based on a fluid flow rate set by the operator and on a prescribed dose value (D). 1. An apparatus for extracorporeal treatment of blood comprising:a filtration unit including a primary chamber and a secondary chamber separated by a semi-permeable membrane;a blood withdrawal line in fluid communication with an inlet of the primary chamber;a blood return line in fluid communication with an outlet of the primary chamber, said blood withdrawal and return lines configured to connect to a patient;a blood pump configured to pump blood through at least one of the blood lines;an effluent fluid line in fluid communication with an outlet of the secondary chamber;at least two further fluid lines selected from a group includinga pre-dilution infusion fluid line in fluid communication with the blood withdrawal line,a post-dilution infusion fluid line in fluid communication with the blood return line,a dialysis fluid line in fluid communication with an inlet of the secondary chamber, anda pre-blood pump infusion fluid line in fluid communication with the blood withdrawal line at a location upstream of the blood pump;a plurality of fluid pumps configured to pump fluid through said fluid lines; anda control unit operably connected to said pumps and to a memory, the control unit configured to:enter in the memory a set value for at least a first fluid flow rate selected from a group of fluid flow rates including{'sub': 'rep1', 'a fluid flow rate Qthrough the pre-dilution infusion fluid line,'}{'sub': 'rep2', 'a fluid flow rate Qthrough the post-dilution infusion fluid line,'}{'sub': 'pbp', 'a fluid flow rate Qthrough the pre-blood pump infusion fluid line,'}{'sub': 'dial', 'claim-text': {'sub': ' ...

BLOOD PURIFICATION APPARATUS

A blood purification apparatus in which whether or not the connection of a communicating line is appropriate can be determined more accurately. A blood purification apparatus includes a control device that is capable of executing a pressure-applying step in which a negative pressure or a positive pressure is applied to a flow route of one of a tube section and a blood circuit; a propagating step in which the negative pressure or the positive pressure applied in the pressure-applying step is propagated to the flow route of an other of the tube section and the blood circuit through the communicating line; and a checking step in which whether or not the propagation of the negative pressure or the positive pressure in the propagating step is successful is checked with reference to the pressure detected by the pressure-detecting device, and in which whether or not the connection of the communicating line is appropriate is checked with reference to whether or not the propagation of the negative pressure or the positive pressure is successful. 1. A blood purification apparatus comprising:a blood circuit including an arterial blood circuit and a venous blood circuit through which blood of a patient is allowed to be extracorporeally circulated;a blood purification device provided between the arterial blood circuit and the venous blood circuit and that purifies the blood flowing in the blood circuit;a tube section including a dialysate introduction line and a dialysate drain line through which dialysate is introduced into and drained from the blood purification device, respectively;a pressure-detecting device that is capable of detecting a pressure in the tube section or a pressure in the blood circuit;a communicating line connected to the tube section and to the blood circuit and that allows a flow route of the tube section and a flow route of the blood circuit to communicate with each other; anda control device that is capable of controlling opening and closing of any of ...

An apparatus for extracorporeal blood treatment

It is disclosed an apparatus for extracorporeal blood treatment ( 1 ) having a control unit ( 15 ) connected to an ultrafiltration device ( 20 ) and to a fluid preparation section ( 30 ) of fresh dialysis liquid. The control unit ( 15 ) is configured to receive measured values of the change of blood volume, the amount of ultrafiltration volume, and conductivity or to the concentration for at least one substance in the blood (BV % mes(t) ; U Fmes(t) , WL mes(t) ; Cb mes(t)) ; the control unit ( 15 ) is also configured to receive prescription values for the same parameters and to control ultrafiltration and adjust conductivity in the fresh dialysis liquid based on the difference between said measured values and said prescription values.

DIALYSIS SYSTEM AND METHODS

Dialysis systems and methods are described which can include a number of features. The dialysis systems described can be to provide dialysis therapy to a patient in the comfort of their own home. The dialysis system can be configured to prepare purified water from a tap water source in real-time that is used for creating a dialysate solution. The dialysis systems described also include features that make it easy for a patient to self-administer therapy. For example, the dialysis systems include disposable cartridge and patient tubing sets that are easily installed on the dialysis system and automatically align the tubing set, sensors, venous drip chamber, and other features with the corresponding components on the dialysis system. Methods of use are also provided, including automated priming sequences, blood return sequences, and dynamic balancing methods for controlling a rate of fluid transfer during different types of dialysis, including hemodialysis, ultrafiltration, and hemodiafiltration. 1. A method of returning blood in a patient tubing set of a dialysis delivery system to a patient after a dialysis treatment , comprising:activating a blood pump coupled to the patient tubing set to draw saline into the patient tubing set and push blood back into the patient;tracking a number of revolutions of the blood pump to determine a volume of saline drawn into the patient tubing set; andde-activating the blood pump when a predetermined volume of saline is drawn into the patient tubing set.2. The method of wherein the predetermined volume comprises 300-500 ml.3. The method of claim 1 , further comprising opening one or more pinch valves of the dialysis delivery system to create a pathway between a saline source and the tubing set.4. The method of claim 3 , further comprising opening one or more pinch valves to create the pathway between the saline source and the tubing set at or adjacent to a patient arterial access site.5. The method of claim 1 , wherein blood is pushed ...

APPARATUS AND METHOD OF CONTROLLING AN EXTRACORPOREAL BLOOD TREATMENT

An apparatus is described for extracorporeal blood treatment, comprising a treatment unit, an extracorporeal blood circuit and a fluid evacuation line. The apparatus comprises a control unit connected to a pressure sensor and a blood pump, the blood pump generating a variable flow with a constant component and a variable component. The control unit receives, from the pressure sensor, a plurality of values and calculates the average pressure value, acquires an estimated value of volume variation in the expansion chamber connected to the variable flow component, calculates, as a function of the pressure values, an estimated value of pressure variation in the expansion chamber that is representative of an oscillating pressure component and determines a representative magnitude of a blood level in the expansion chamber as a function of the average pressure value, the estimated value of volume variation and the estimated pressure variation in the expansion chamber. 115-. (canceled)16. A method for reducing the risk of infusion of gas microbubbles in a patient , the method comprising:moving a first actuator to generate a variable flow comprising a constant flow component of a desired flow value and a variable flow component oscillating about the constant flow component, the variable flow component generating in an expansion chamber a pressure progression that is variable in time, the pressure progression comprising a pressure component oscillating about a mean value;receiving from at least one sensor associated with the expansion chamber and configured to sense pressure values internally of the expansion chamber, a plurality of pressure values for a time period comprising a plurality of pressure oscillations about the mean value, the pressure values being measured at successive time instants;calculating, as a function of the pressure values, an average pressure value;acquiring an estimated volume variation value in the expansion chamber linked to the variable flow ...

OPTICAL LEVEL CONTROL SYSTEM

A perfusion system includes a fluid reservoir configured to hold a portion of fluid, the portion of fluid having a volume, the fluid reservoir having a total capacity that is greater than the volume; an imaging device, the imaging device configured to obtain image data corresponding to the fluid reservoir; and a controller. The controller is configured to receive the image data from the imaging device; determine the volume based on the image data; and facilitate control, in response to at least one of a user input and the determined volume of the portion of fluid, of an operating parameter corresponding to the fluid reservoir to facilitate changing or maintaining the volume of the portion of the fluid. 1. A cardiopulmonary bypass (CPB) perfusion system , comprising:a fluid reservoir having a shape and a capacity, the fluid reservoir configured to hold a fluid having a volume;an imaging device configured to obtain image data corresponding to the fluid reservoir; anda controller configured to:receive the image data from the imaging device;determine the volume based on the image data associated with an image region having a shape that corresponds to the shape of the fluid reservoir;facilitate control, of an operating parameter corresponding to the fluid reservoir to facilitate changing or maintaining the volume of the fluid; andwherein the image region is configured to facilitate positioning of the imaging device in relation to the fluid reservoir by providing a notification if the image region is not aligned with the fluid reservoir.2. The system of claim 1 , wherein the imaging device comprises at least one of a camera claim 1 , a photoconductive sensor claim 1 , a photodiode claim 1 , a phototransistor claim 1 , a photovoltaic sensor claim 1 , and a charge coupled device (CCD) sensor.3. The system of claim 1 , wherein the controller is further configured to provide claim 1 , via a control panel having a display device and based on the image data claim 1 , a ...

Automatic Detection and Adjustment of a Pressure Pod Diaphragm

A system for controlling the position of a diaphragm in a diaphragm-containing pressure pod, is provided. The system can include a peristaltic pump, a pressure pod having a flow-through fluid side and a gas side that are separated by a diaphragm, and a pressure sensor operatively connected to the gas side. The pressure sensor is configured to sense pulses of pressure resulting from movement of the diaphragm and caused by the action of the peristaltic pump. A gas source and a valve can be in fluid communication with the gas side of the pressure pod and can be configured to provide gas to, or vent gas from, the gas side. A controller receives pressure signals from the pressure sensor and controls the valve in response, and in so doing, controls the position of the diaphragm. Methods for positioning the diaphragm are also included.

Stationary Optical Monitoring System For Blood Processing System

A blood processing system includes a centrifuge and an optical monitoring system mounted at a stationary radial position with respect to the centrifuge. A flow circuit may be mounted within the centrifuge, with an umbilicus of the flow circuit extending outside of the centrifuge. A midsection of the umbilicus is orbited around a rotational axis of the centrifuge at a uniform first speed, which causes the centrifuge to rotate at a non-uniform second speed that is approximately double the first speed. The monitoring system is configured to view the flow circuit through a radial window of the centrifuge to determine a characteristic of the flow circuit. The yoke and/or umbilicus may occasionally move into position between the monitoring system and the window, so a controller of the monitoring system is configured to determine when unobstructed light reflected through the window by the centrifuge is received by the monitoring system. 1. A blood processing system , comprising:a centrifuge configured for rotation about a rotational axis, wherein the centrifuge includes a radially facing window and is configured to receive at least a portion of a disposable flow circuit including an umbilicus;a yoke configured to orbit a midsection of the umbilicus around the rotational axis at a uniform first speed so as to cause the centrifuge to rotate at a non-uniform second speed with an average speed that is approximately double the first speed; the light source is oriented to emit a light passing through the window when the window is rotated into alignment with the monitoring system,', 'the light detector is oriented to receive a light reflected through the window by the centrifuge when the window is aligned with the monitoring system,', 'the controller is configured to receive a plurality of signals from the light detector when the light detector receives reflected light during a timing cycle,', 'a portion of the yoke and the midsection of the umbilicus are rotatable into and out ...

METHOD FOR ASSESSING A PATIENT'S FLUID STATUS AND/OR SENTISIVITY TO FLUID REMOVAL, CONTROLLER, AND DEVICES

The present invention relates to a method for assessing a patient's sensitivity to fluid removal from the patient's vascular system or to fluid replacement or addition with regard to the patient's hydration state, the method comprising the step of determining a value reflecting the distribution of fluid between at least two distribution spaces of the body of the patient or changes thereof from measured or calculated values, and assessing whether the value fulfills at least one criterion. It also relates to a controller, an apparatus, a device, a digital storage device, a computer program product, and a computer program. 126to . (canceled)27. A blood treatment system for treating the blood of a patient , comprising:an obtaining system for obtaining a first value reflecting the distribution of fluid between at least a first and a second distribution space of the patient; and,a control system,wherein the control system determines whether said first value fulfills at least one criterion.28. The blood treatment system according to claim 27 , wherein the blood treatment system is configured to treat a patient by dialysis.29. The blood treatment system according to claim 28 , wherein the blood treatment system is configured to treat a patient or the patient's extracorporeally flowing blood by hemofiltration claim 28 , ultrafiltration claim 28 , and/or hemodialysis.30. The blood treatment system according to claim 27 , wherein the first or the second distribution space is selected from the group consisting of: the blood volume claim 27 , the extracellular fluid volume claim 27 , and the interstitium.31. The blood treatment system according to claim 27 , wherein the control system is configured to determine a saturation degree of at least one distribution space of the patient as said first value.32. The blood treatment system according to claim 27 , wherein the blood treatment system further comprises a determining system claim 27 , said determining system being configured ...

ADAPTIVE SYSTEM FOR BLOOD FLUID REMOVAL

Methods for monitoring patient parameters and blood fluid removal system parameters include identifying those system parameters that result in improved patient parameters or in worsened patient parameters. By comparing the patient's past responses to system parameters or changes in system parameters, a blood fluid removal system may be able to avoid future use of parameters that may harm the patient and may be able to learn which parameters are likely to be most effective in treating the patient in a blood fluid removal session. 1. A method carried out by a blood fluid removal system , comprising:initiating a blood fluid removal session, using a blood fluid removal device, with initial system parameters;acquiring a first set of data regarding one or more patient physiological parameters, wherein the one or more patient physiological parameters include at least one of pH and concentration of an electrolyte wherein at least one patient physiological parameter is measured in a dialysate;storing the first data set in a most effective to date data set memory;associating the initial system parameters in an increased effectiveness lookup table with the first data set;adjusting at least one parameter of the blood fluid removal session by adjusting the dialysate to arrive at adjusted system parameters;acquiring a second set of data regarding the one or more patient physiological parameters after the at least one parameter of the blood fluid removal session has been adjusted; anddetermining which of the first and second set of data includes at least one value closer to a target value; storing in the increased effectiveness lookup table data regarding the data set having at least one value closer to the target value; and associating data regarding the adjusted system parameters with the data set having at least one value closer to the target value; andrepeating the process beginning with acquiring a first set of data regarding one or more patient physiological parameters; ...

Control System

A control system controlling blood gas values in blood processed by an oxygenator, wherein the oxygenator generates arterial blood by exposing venous blood to oxygen from an oxygenation gas supply, comprises a monitoring arrangement to determine a level of the blood gas values in the arterial blood and a controller that is responsive to the monitoring arrangement and configured to control parameters of the oxygenation gas supply to the oxygenator. This allows the blood gas values to be adjusted toward a pre-determined level. 1. A control system controlling at least one blood gas value in blood processed by an oxygenator of an extracorporeal perfusion system , wherein the oxygenator is configured to generate arterial blood by exposing venous blood to oxygen from an oxygenation gas supply , the control system comprising:a monitoring arrangement to determine a level of the at least one blood gas value in the arterial blood, anda controller responsive to the monitoring arrangement, the controller configured to control parameters of the oxygenation gas supply to the oxygenator, to adjust at least one of the blood gas values toward a pre-determined level.2. The control system according to claim 1 , wherein the blood gas values comprise at least one of (a) the partial pressure of oxygen in the arterial blood and (b) the partial pressure of carbon dioxide in the arterial blood.3. The control system according to claim 1 , wherein the controller comprises a configuration permitting it to alter at least one of (a) the composition of the oxygenation gas supplied to the oxygenator and (b) the flow rate of the oxygenation gas supplied to the oxygenator.4. (canceled)5. The control system according to claim 1 , wherein the controller is configured to adjust the partial pressure of carbon dioxide in the arterial blood by altering the flow rate of the oxygenation gas supply.6. The control system according to claim 1 , wherein the controller is configured to adjust the partial ...

SYSTEM AND METHOD FOR DETECTING AN OPERATING STATE OR A COURSE OF TREATMENT IN A BLOOD TREATMENT

A computer-implemented method and a computer system are disclosed. The computer system () is suitable for detecting an operating state of a blood treatment machine () or of a course of treatment in a blood treatment or a deviation from an ideal or uncomplicated operating state or a course of treatment. The computer system comprises a first interface (), which is adjusted to receive an operating parameter monitoring signal, wherein the operating parameter monitoring signal represents a time-dependent signal of a sensor for monitoring an operating parameter of the blood treatment machine or a signal derived from the time-dependent signal of the operating parameter, and 12003001002012022020n. A computer system ( , ) for detecting an operating state of a blood treatment machine ( , , , . . . , ) or of a course of treatment in a blood treatment or a deviation from an ideal or uncomplicated operating state or course of treatment comprising:{'b': 20', '312, 'a first interface (, ), which is adjusted to receive an operating parameter monitoring signal, wherein the operating parameter monitoring signal represents a time-dependent signal of a sensor for monitoring an operating parameter of the blood treatment machine or a signal derived from the time-dependent signal of the operating parameter,'}{'b': 20', '312, 'a second interface (, ) which is adjusted to receive a user response signal, wherein a user response signal represents a signal of a user input with respect to the operating state or the course of treatment or the deviation from the ideal or uncomplicated course of treatment or operating state of a blood treatment performed using the blood treatment machine,'}{'b': 40', '213, 'an evaluation unit (, ), which is adjusted to generate allocation data or reference data, establishing a correlation between a determined user response and a respective operating parameter monitoring signal, a memory unit, which is configured to save the allocation data and reference data, ...