MEDICAL DEVICE FOR THE ADMINISTRATION OF THERAPEUTIC GAS

DEVICE FOR THE ADMINISTRATION OF CO

Therapeutic gas delivery device with pulsed and continuous flow control

Described are methods and devices for therapeutic or medical gas delivery that utilize at least one proportional control valve (107) and at least one binary control valve (109). The proportional control valve may be in series with the binary control valve to provide a valve combination capable of pulsing therapeutic gas at different flow rates, depending on the setting of the proportional control valve. Alternatively, the proportional control valve and binary control valve may be in parallel flow paths.

Breathing control using high flow respiration assistance

High flow therapy is used to treat Cheyne-Stokes respiration and other types of periodic respiration disorders by periodic application of high flow therapy, adjustment of high flow therapy flow rates and/or periodic additions of CO2 or O2 into the air flow provided to the patient.

AIR TREATMENT SYSTEMS AND METHODS

An air treatment unit may include an air inlet to receive a flow of input air for treatment and a reaction reservoir configured to hold an aqueous air treatment solution. The air treatment unit may also include an air dispersing element flow connected with the air inlet, wherein the air dispersing element is configured to convert at least a portion of the flow of input air into a plurality of microbubbles for introduction into the aqueous air treatment solution, such that an amount of one or more target gas species contained within the plurality of microbubbles is reduced through reaction with the aqueous air treatment solution. The unit may include an air outlet configured to output treated air from the reaction reservoir.

METHODS FOR EASING PAIN AND ANXIETY FROM ATRIAL OR VENTRICULAR DEFIBRILLATION

Methods for easing a patient's pain and anxiety from atrial or ventricular defibrillation are disclosed. The methods include causing the patient to inhale a medical gas ( 2) prior to activation of a atrial defibrillation device or subsequent to activation of a ventricular defibrillation device. In the former case, the inhalation produces analgesia , anxiolysis or anterograde amnesia prior to, during and after the atrial defibrillation. In the latter case, the inhalation produces analgesia, anxiolysis or anterograde amnesia.

SYSTEM AND METHOD OF ADMINISTERING A PHARMACEUTICAL GAS TO A PATIENT

Systems for delivering pharmaceutical gas to a patient. The systems utilize a high flow valve and a low flow valve in parallel flow paths. The pharmaceutical gas may be provided as a pulse during the first half of the patient's inspiratory cycle.

Administering the patient medical gas system and method

METHOD AND APPARATUS FOR THE ADMINISTRATION OF CO

The present invention relates to a method and apparatus for the administration of carbon monoxide (CO) to a patient. It allows the safe and effective use of carbon monoxide as a medicament.

Devices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery

A valve assembly having a housing and a valve, the valve being disposed within the housing, a first indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member, and a radio frequency identification device adapted to communicate with a radio frequency receiver, the valve being configured to align with a canister, seal the canister and open in a single movement. A drug containment device having said valve assembly is also disclosed.

A VAPOUR GENERATING DEVICE

Medizinische Vorrichtung zur Verabreichung von therapeutischem Gas

Methods and devices for administration of therapeutic gases

Therapeutic gas delivery device with pulsed and continuous flow control

Abstract A therapeutic gas delivery device comprising: an inlet to connect to a source of therapeutic gas; an outlet to connect to a device that introduces the therapeutic gas to a patient; at least one binary control valve in fluid communication with the inlet and outlet that delivers a constant flow of the therapeutic gas; at least one proportional control valve in fluid communication with the inlet and outlet that delivers a variable flow of the therapeutic gas; and a control system that delivers the therapeutic gas through one or more of the binary control valve and the proportional control valve. 0") C>~ -CD oc I Il I-r ...

METHOD AND APPARATUS FOR THE ADMINISTRATION OF CO

The present invention relates to a method and apparatus for the administration of carbon monoxide (CO) to a patient. It allows the safe and effective use of carbon monoxide as a medicament.

DEVICES AND METHODS FOR ENGAGING INDEXED VALVE AND PRESSURIZED CANISTER ASSEMBLY WITH COLLAR AND FOR LINEAR ACTUATION BY PLUNGER ASSEMBLY INTO FLUID COMMUNICATION WITH DEVICE FOR REGULATING DRUG DELIVERY

An indexed drug delivery device (70) comprising a valve assembly (13) comprising a housing (26) and a valve, the valve disposed within the housing, one or more keys (34,38) integral to the housing, the keys complementary to corresponding openings on a collar (12), a pressurized canister (28) in fluid communication with the valve assembly, the canister containing an active pharmaceutical ingredient and an inactive carrier gas, a receiving assembly comprising a receptacle adapted to engage at least a portion of the housing, a seat adapted to engage the valve, and, a plunger assembly adapted to linearly actuate the valve assembly and canister along an axis and to engage the valve and seat, the plunger assembly comprising a carriage fixed to the collar, and, a lever having a cam adapted to engage a spring, the spring adapted to linearly actuate the carriage, valve assembly, canister and collar along the axis.

SYSTEM AND METHOD OF ADMINISTERING A PHARMACEUTICAL GAS TO A PATIENT

Systems for delivering pharmaceutical gas to a patient. The systems utilize a high flow valve and a low flow valve in parallel flow paths. The pharmaceutical gas may be provided as a pulse during the first half of the patient's inspiratory cycle.

SYSTEMS AND METHODS FOR PROMOTING WOUND HEALING

In various embodiments, provided are topical gas delivery systems and methods for promoting wound healing. A provided gas delivery system comprises a gas reservoir comprising at least one chamber adapted to contain one or more therapeutic gases selected from NO, CO, O2, air, or combinations thereof, and at least one gas permeable membrane operably coupled to the reservoir. A provided method comprises using a provided gas delivery system to deliver the one or more therapeutic gases to a wound site such that a NO/ONOO- ratio suitable for promoting wound healing is achieved at the wound site.

Air treatment systems and methods

An air treatment unit may include an air inlet to receive a flow of input air for treatment and a reaction reservoir configured to hold an aqueous air treatment solution. The air treatment unit may also include an air dispersing element flow connected with the air inlet, wherein the air dispersing element is configured to convert at least a portion of the flow of input air into a plurality of microbubbles for introduction into the aqueous air treatment solution, such that an amount of one or more target gas species contained within the plurality of microbubbles is reduced through reaction with the aqueous air treatment solution. The unit may include an air outlet configured to output treated air from the reaction reservoir.

УСТРОЙСТВА И СПОСОБЫ ОБЕСПЕЧЕНИЯ ВЗАИМОДЕЙСТВИЯ УКАЗАТЕЛЬНОГО УЗЛА, СОДЕРЖАЩЕГО КЛАПАН И НАХОДЯЩИЙСЯ ПОД ДАВЛЕНИЕМ БАЛЛОН, С ХОМУТОМ И ЛИНЕЙНОГО ПЕРЕМЕЩЕНИЯ ТОЛКАТЕЛЬНЫМ УЗЛОМ ДЛЯ СОЗДАНИЯ ГИДРОДИНАМИЧЕСКОЙ СВЯЗИ С УСТРОЙСТВОМ ДЛЯ РЕГУЛИРУЕМОЙ ПОДАЧИ МЕДИКАМЕНТА

Группа изобретений относится к медицине. Указательное устройство для подачи медикамента, содержащее клапанный узел, содержащий корпус и клапан, расположенный в корпусе, по меньшей мере одну из встроенных в корпус шпонок, выполненных дополняющими для соответствующих отверстий на хомуте, находящийся под повышенным давлением баллон, сообщающийся через текучую среду с клапанным узлом, содержащий активный фармацевтический ингредиент и неактивный транспортирующий газ, принимающий узел, содержащий гнездо, выполненное с обеспечением возможности взаимодействия по меньшей мере с частью корпуса, седло, выполненное с обеспечением возможности взаимодействия с клапаном, и толкательный узел, выполненный с обеспечением возможности линейного перемещения клапанного узла и баллона вдоль оси и взаимодействия клапана с седлом, содержащий каретку, прикрепленную к хомуту, и рычаг, имеющий кулачок, выполненный с обеспечением возможности взаимодействия с пружиной, выполненной с обеспечением возможности линейного перемещения каретки, клапанного узла, баллона и хомута вдоль оси. Группа изобретений позволяет улучшить соединение баллона с регулировочным устройством и его защиту. 7 н. и 24 з.п. ф-лы, 8 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 541 742 C2 (51) МПК A61M 16/12 (2006.01) A61M 16/20 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2011147150/14, 27.05.2009 (24) Дата начала отсчета срока действия патента: 27.05.2009 (43) Дата публикации заявки: 10.07.2013 Бюл. № 19 (73) Патентообладатель(и): ИНО ТЕРАПЬЮТИКС ЛЛС (US) R U Приоритет(ы): (22) Дата подачи заявки: 27.05.2009 (72) Автор(ы): МОНТГОМЕРИ Фредерик Дж. (US), БАТ Дункан П. (US), ЛИ Даниель Цзюйюнг (US), БИБА Скот Игнатиус (US), БАККЭН Тодд Дж. (US) (45) Опубликовано: 20.02.2015 Бюл. № 5 US5381836A, 17.01.1995. US2009071481A1, 19.03.2009. EP1205203A2, 15.05.2002. RU2146153C1, 10.03.2000 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 27.12.2011 (86 ...

Devices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery

System and method for carbon monoxide atmosphere stored blood components

A system, apparatus, and method using carbon monoxide for treatment of platelets, and optionally other blood components and/or whole blood, allowing extended storage and increased viability of the stored blood platelets in vivo. The system allows an efficient use of the stored platelets by dividing the platelets into a population with a short residual lifetime for immediate use and a population that can remain in storage for longer. The storage apparatus enables safe platelet preservation and is equipped with an alarm to detect CO leakage.

DEVICE FOR DETERMINATION OF THE HEMOGLOBIN AMOUNT OF A PATIENT

The invention relates to a device for determining the hemoglobin count of a patient, having: a closed gas volume (100); a gas outlet having a mouthpiece (47), wherein the mouthpiece (47) is designed to enable an inhalation and exhalation of gas into and out of the closed gas volume (100); a means for supplying carbon monoxide into the closed gas volume (100); characterized in that the means for supplying carbon monoxide has a carbon monoxide reservoir (15), which has sensors for determining the temperature (19) and pressure (17) of the carbon monoxide in the carbon monoxide reservoir (15).

A VAPOUR GENERATING DEVICE

A vapour generating device comprises an oven arranged to receive a substrate to be vaporized, an inlet, an outlet, an airflow passageway for providing a fluid connection between the inlet and the outlet via the oven through which generated vapour can flow from the oven to the outlet. A device controller and a humidity sensor for generating a measurement of a vapor produced by the substrate are provided. The controller is operable to control the operation of the device based on measurement data from the humidity sensor.

GAS DELIVERY DEVICE AND SYSTEM

A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gas are also described.

Nitric oxide delivery device

A nitric oxide delivery device including a valve assembly, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gases containing nitric oxide are also described.

Implantable heart treatment systems, devices, and methods

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; and an energy-carrier molecule delivery device coupled to the substrate and configured to supply one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body.

НОСОВОЙ ПРОМЫВОЧНЫЙ КАТЕТЕР

Настоящее изобретение относится к медицинской технике, а именно к носовому промывочному катетеру и, в частности, к новому носовому промывочному катетеру, предназначенному для удаления носовой слизи и корок глубоко в носовой полости и носоглотке для улучшения симптомов хронического синусита. Носовой промывочный катетер, который может быть приспособлен к шприцу для промывания носовой полости и носоглотки, содержит корпус катетера и соединитель, выполненный снаружи корпуса катетера. Корпус катетера изготовлен из силикона, латекса, термопластичного эластомера или другого мягкого и эластичного материала, позволяющего больному вставлять его в носовую полость и носоглотку. Корпус катетера имеет закрытый конец, открытый конец на противоположной стороне и боковые отверстия, расположенные возле закрытого конца. Общая площадь указанных боковых отверстий составляет не более 4,123 мм. Преимущество настоящего изобретения заключается в повышении действенности и эффективности лечения промыванием носа благодаря оптимальной силе струй. 3 з.п. ф-лы, 18 ил. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 695 725 C1 (51) МПК A61H 35/04 (2006.01) A61M 25/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61H 35/04 (2019.02); A61L 29/06 (2019.02); A61M 25/00 (2019.02); A61M 25/007 (2019.02); A61M 3/022 (2019.02); A61M 3/0279 (2019.02) (21)(22) Заявка: 2018114063, 14.10.2015 14.10.2015 Дата регистрации: 25.07.2019 (45) Опубликовано: 25.07.2019 Бюл. № 21 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 17.04.2018 (86) Заявка PCT: R U 2 6 9 5 7 2 5 C 1 CN 2015/091911 (14.10.2015) (87) Публикация заявки PCT: WO 2017/063152 (20.04.2017) Адрес для переписки: 123242, Москва, пл. Кудринская, 1, а/я 35, "Михайлюк, Сороколат и партнеры патентные поверенные" (54) НОСОВОЙ ПРОМЫВОЧНЫЙ КАТЕТЕР (57) Реферат: Настоящее изобретение относится к медицинской технике, а именно к носовому промывочному катетеру и, в частности, к новому носовому ...

System and method for controlling gas composition in a surgical cavity during endoscopic surgical procedures

A method for controlling gas composition in a surgical cavity during an endoscopic surgical procedure includes monitoring for a plurality of gas species in a gas flow from a surgical cavity of a patient. The method includes measuring the plurality of gas species in the gas flow from the surgical cavity and determining if the gas species measured in the gas flow from the surgical cavity are each present and/or within a respective desired range. The method includes adding gas into the surgical cavity if one or more gas species in the plurality of gas species is outside of the respective desired range so as to bring a composition of gas species in the surgical cavity within the respective desired range.

SYSTEM AND METHOD OF ADMINISTERING A PHARMACEUTICAL GAS TO A PATIENT

A method and system for delivering a pharmaceutical gas to a patient. The method and system provide a known desired quantity of the pharmaceutical gas to the patient independent of the respiratory pattern of the patient. The preferred pharmaceutical gases are CO and NO, both of which are provided as a concentration in a carrier gas. The gas control system determines the delivery of the pharmaceutical gas to the patient to result in the known desired quantity (e.g. in molecules, milligrams or other quantified units) of the pharmaceutical gas being delivered. Upon completion of that known desired quantity of pharmaceutical gas over a plurality of breaths, the system can either terminate any further delivery of the pharmaceutical gas or can activate an alarm to alert the user that the known quantity has been delivered. The system also has alarm functions to alert the user of possible malfunctions of the system.

GAS DELIVERY DEVICE AND SYSTEM

A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gas are also described.

THERAPEUTIC VAPORIZER

A therapeutic vaporizer is disclosed having two or more housing portions configured to form an inner cavity. The housing portions are movable between an open and closed position, such that at least a portion of the inner cavity is enclosed when the housing portions are in the closed position. The vaporizer includes at least one accessory-receiving element configured to receive at least one accessory within the inner cavity when the housing portions are in the closed position.

THERAPEUTIC VAPORIZER

A therapeutic vaporizer is disclosed having two or more housing portions configured to form an inner cavity. The housing portions are movable between an open and closed position, such that at least a portion of the inner cavity is enclosed when the housing portions are in the closed position. The vaporizer includes at least one accessory-receiving element configured to receive at least one accessory within the inner cavity when the housing portions are in the closed position.

METHODS FOR TREATING CARBON MONOXIDE POISONING BY TANGENTIAL FLOW FILTRATION OF BLOOD

The present application relates to a system and method for treating carbon monoxide poisoning. The system and method comprises passing the blood of a subject in need of such treatment through a filter unit comprising a gas permeable membrane to remove carbon monoxide from the blood by filtration against an extraction fluid enriched with oxygen and/or by exposure to one or more agents suitable for removing carbon monoxide or converting carbon monoxide to carbon dioxide, which is more readily exchangeable with oxygen compared to carbon monoxide.

Systems And Methods Of Administering A Pharmaceutical Gas to A Patient

Methods and systems for delivering a pharmaceutical gas to a patient. The methods and systems provide a known desired quantity of the pharmaceutical gas to the patient independent of the respiratory pattern of the patient over a plurality of breaths every nth breath, where n is greater than or equal to 1. The pharmaceutical gases include CO and NO, both of which are provided as a concentration in a carrier gas. The gas control system determines the delivery of the pharmaceutical gas to the patient to result in the known desired quantity (e.g. in molecules, milligrams or other quantified units) of the pharmaceutical gas being delivered. Upon completion of that known desired quantity of pharmaceutical gas over a plurality of breaths, the system can either terminate, continue, activate and alarm, etc.

Drug administration controller

A drug administration controller has a sensor that generates a sensor signal to a physiological measurement device, which measures a physiological parameter in response. A control output responsive to the physiological parameter or a metric derived from the physiological parameter causes a drug administration device to affect a treatment of a person, such as by initiating, pausing, halting or adjusting a dosage of drugs administered to the person.

Device for treatment of chronic respiratory diseases

SYSTEM AND METHOD FOR CONTROLLING GAS COMPOSITION IN A SURGICAL CAVITY DURING ENDOSCOPIC SURGICAL PROCEDURES

A method for controlling gas composition in a surgical cavity during an endoscopic surgical procedure includes monitoring for a plurality of gas species in a gas flow from a surgical cavity of a patient. The method includes measuring the plurality of gas species in the gas flow from the surgical cavity and determining if the gas species measured in the gas flow from the surgical cavity are each present and/or within a respective desired range. The method includes adding gas into the surgical cavity if one or more gas species in the plurality of gas species is outside of the respective desired range so as to bring a composition of gas species in the surgical cavity within the respective desired range.

METHODS AND DEVICES FOR ADMINISTRATION OF THERAPEUTIC GASES

Methods for administering medical gases are disclosed including providing the medical gas in compressed gas cartridges (210) containing an amount of the medical gas preferably corresponding substantially to a unit dose of the medical gas and providing a patient with means to access the medical gas from the gas cartridge upon need therefor. Apparatus for administering medical gases is also disclosed including a housing (300), a cassette (200) associated with the housing containing at least one compressed gas cartridge (210) preferably containing at least an amount of the medical gas substantially as required for a single dose and a patient supply interface to provide the medical gas to the patient.

Method for administration of therapeutic gases

Methods for administering medical gases are disclosed including providing the medical gas in compressed gas cartridges containing an amount of the medical gas preferably corresponding substantially to a unit dose of the medical gas and providing a patient with means to access the medical gas from the gas cartridge upon need therefor. Apparatus for administering medical gases is also disclosed including a housing, a cassette associated with the housing containing at least one compressed gas cartridge preferably containing at least an amount of the medical gas substantially as required for a single dose and a patient supply interface to provide the medical gas to the patient.

Medical Carbon Monoxide Delivery System

A medical carbon monoxide generator provides for a solid carbon material that may be heated at substantially normal atmospheric pressure to provide a source of medical quality carbon monoxide. The heating source may be an electrical filament or laser controllable by a microcontroller to provide accurate delivery rates and amounts. In one embodiment, a replaceable cartridge holding the carbon material may be used.

УСТРОЙСТВА И СПОСОБЫ ОБЕСПЕЧЕНИЯ ВЗАИМОДЕЙСТВИЯ УКАЗАТЕЛЬНОГО УЗЛА, СОДЕРЖАЩЕГО КЛАПАН И НАХОДЯЩИЙСЯ ПОД ДАВЛЕНИЕМ БАЛЛОН, С ХОМУТОМ И ЛИНЕЙНОГО ПЕРЕМЕЩЕНИЯ ТОЛКАТЕЛЬНЫМ УЗЛОМ ДЛЯ СОЗДАНИЯ ГИДРОДИНАМИЧЕСКОЙ СВЯЗИ С УСТРОЙСТВОМ ДЛЯ РЕГУЛИРУЕМОЙ ПОДАЧИ МЕДИКАМЕНТА

... 1. Указательный клапанный узел, содержащий:корпус и клапан, расположенный в корпусе, ипервый встроенный в корпус указательный элемент, выполненный с обеспечением возможности быть дополняющим для второго указательного элемента.2. Указательное содержащее медикамент устройство, содержащее:клапанный узел, содержащий корпус и клапан, расположенный в корпусе,первый встроенный в корпус указательный элемент, выполненный с обеспечением возможности быть дополняющим для второго указательного элемента, ибаллон, сообщающийся через текучую среду с клапанным узлом и содержащий активный фармацевтический ингредиент и неактивный транспортирующий газ.3. Устройство по п.2, дополнительно содержащее третий встроенный в корпус указательный элемент, выполненный с обеспечением возможности быть дополняющим для четвертого указательного элемента,причем первый указательный элемент выполнен недополняющим для четвертого указательного элемента, а третий указательный элемент выполнен недополняющим для второго указательного ...

УСТРОЙСТВА И СПОСОБЫ ОБЕСПЕЧЕНИЯ ВЗАИМОДЕЙСТВИЯ УКАЗАТЕЛЬНОГО УЗЛА, СОДЕРЖАЩЕГО КЛАПАН И НАХОДЯЩИЙСЯ ПОД ДАВЛЕНИЕМ БАЛЛОН, С ХОМУТОМ И ЛИНЕЙНОГО ПЕРЕМЕЩЕНИЯ ТОЛКАТЕЛЬНЫМ УЗЛОМ ДЛЯ СОЗДАНИЯ ГИДРОДИНАМИЧЕСКОЙ СВЯЗИ С УСТРОЙСТВОМ ДЛЯ РЕГУЛИРУЕМОЙ ПОДАЧИ МЕДИКАМЕНТА

FIELD: medicine. SUBSTANCE: group of inventions refers to medicine. An indicator drug supply device comprising a valve assembly with a body and an in-built valve, at least one of in-built connectors configured as supplemental for respective collar holes, a high pressurised cylinder being in fluid connection with the valve assembly, containing an active pharmaceutical ingredient and an inactive carrier gas, a receiver assembly comprising a seat configured to enable an interaction to at least a portion of the body, the seat configured to enable an interaction to the valve, and a pusher assembly configured to enable a linear motion of the valve assembly and cylinder along the axis and an interaction of the valve to the seat, comprising a carriage attached to the collar, and a lever having a cam configured to enable an interaction to a syringe configured to enable a linear motion of the carriage, valve assembly and collar along the axis. EFFECT: group of inventions provides improving the cylinder connection to the regulating device and the protection thereof. 31 cl, 8 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 541 742 C9 (51) МПК A61M 16/12 (2006.01) A61M 16/20 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) СКОРРЕКТИРОВАННОЕ ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ Примечание: библиография отражает состояние при переиздании (21)(22) Заявка: 2011147150/14, 27.05.2009 (24) Дата начала отсчета срока действия патента: 27.05.2009 (43) Дата публикации заявки: 10.07.2013 Бюл. № 19 (73) Патентообладатель(и): ИНО ТЕРАПЬЮТИКС ЛЛС (US) R U Приоритет(ы): (22) Дата подачи заявки: 27.05.2009 (72) Автор(ы): МОНТГОМЕРИ Фредерик Дж. (US), БАТ Дункан П. (US), ЛИ Даниель Цзюйюнг (US), БИБА Скот Игнатиус (US), БАККЭН Тодд Дж. (US) (45) Опубликовано: 20.02.2015 Версия коррекции №1 (W1 C2) (48) Коррекция опубликована: 10.07.2015 Бюл. № 19 5381836 A, 17.01.1995. US 2009071481 A1, 19.03.2009. EP 1205203 A2, 15.05.2002. RU 2146153 C1, 10.03.2000 C 9 C 9 (56) Список документов, ...

METHODS AND DEVICES FOR ADMINISTRATION OF THERAPEUTIC GASES

Therapeutic gas delivery device with pulsed and continuous flow control

Described are methods and devices for therapeutic or medical gas delivery that utilize at least one proportional control valve (107) and at least one binary control valve (109). The proportional control valve may be in series with the binary control valve to provide a valve combination capable of pulsing therapeutic gas at different flow rates, depending on the setting of the proportional control valve. Alternatively, the proportional control valve and binary control valve may be in parallel flow paths.

BREATHING CONTROL USING HIGH FLOW RESPIRATION ASSISTANCE

High flow therapy is used to treat Cheyne-Stokes respiration and other types of periodic respiration disorders by periodic application of high flow therapy, 5 adjustment of high flow therapy flow rates and/or periodic additions of C02 or 02 into the air flow provided to the patient. -31- ...

METHODS FOR EASING PAIN AND ANXIETY FROM ATRIAL OR VENTRICULAR DEFIBRILLATION

Methods for easing a patient's pain and anxiety from atrial or ventricular defibrillation are disclosed. The methods include causing the patient to inhale a medical gas (2) prior to activation of a atrial defibrillation device or subsequent to activation of a ventricular defibrillation device. In the former case, the inhalation produces analgesia, anxiolysis or anterograde amnesia prior to, during and after the atrial defibrillation. In the latter case, the inhalation produces analgesia, anxiolysis or anterograde amnesia.

THERAPEUTIC GAS DELIVERY DEVICE WITH PULSED AND CONTINUOUS FLOW CONTROL

Described are methods and devices for therapeutic or medical gas delivery that utilize at least one proportional control valve (107) and at least one binary control valve (109). The proportional control valve may be in series with the binary control valve to provide a valve combination capable of pulsing therapeutic gas at different flow rates, depending on the setting of the proportional control valve. Alternatively, the proportional control valve and binary control valve may be in parallel flow paths.

MODULAR EXTRACORPOREAL SYSTEMS AND METHODS FOR TREATING BLOOD-BORNE DISEASES

Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.

DEVICES AND METHODS FOR ENGAGING INDEXED VALVE AND PRESSURIZED CANISTER ASSEMBLY WITH COLLAR AND FOR LINEAR ACTUATION BY PLUNGER ASSEMBLY INTO FLUID COMMUNICATION WITH DEVICE FORREGULATING DRUG DELIVERY

An indexed drug delivery device (70) comprising a valve assembly (13) comprising a housing (26) and a valve, the valve disposed within the housing, one or more keys (34,38) integral to the housing, the keys complementary to corresponding openings on a collar (12), a pressurized canister (28) in fluid communication with the valve assembly, the canister containing an active pharmaceutical ingredient and an inactive carrier gas, a receiving assembly comprising a receptacle adapted to engage at least a portion of the housing, a seat adapted to engage the valve, and, a plunger assembly adapted to linearly actuate the valve assembly and canister along an axis and to engage the valve and seat, the plunger assembly comprising a carriage fixed to the collar, and, a lever having a cam adapted to engage a spring, the spring adapted to linearly actuate the carriage, valve assembly, canister and collar along the axis.

Treatment of evaporator

Implantable heart treatment systems, devices, and methods

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; and an oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion.

SYSTEMS AND METHODS TO IMPROVE ORGAN OR TISSUE FUNCTION AND ORGAN OR TISSUE TRANSPLANT LONGEVITY

The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack. 1. A method for improving organ or tissue function or organ or tissue transplant longevity , comprising: administering carbon monoxide (CO)-containing gas a plurality of times to a patient in need of therapy , at a constant alveolar concentration for at least about 30 minutes.2. The method of claim 1 , wherein the patient is a transplant recipient claim 1 , optionally selected from kidney claim 1 , liver claim 1 , lung claim 1 , pancreas claim 1 , heart claim 1 , bone marrow claim 1 , and intestine.3. The method of or claim 1 , wherein the patient is experiencing or is at risk of acute rejection claim 1 , chronic allograft rejection claim 1 , vascular rejection claim 1 , or graft versus host disease (GVHD).4. The method of or claim 1 , wherein the patient has a condition selected from a chronic kidney fibrosing condition claim 1 , a chronic hepatic fibrosing condition claim 1 , a chronic lung fibrosing conditions claim 1 , myocardial fibrosis claim 1 , pancreatic fibrosis claim 1 , pancreatitis claim 1 , gastrointestinal fibrosis or strictures claim 1 , vascular fibrosis or strictures claim 1 , progressive systemic sclerosis (PSS) claim 1 , scleroderma claim 1 , esophageal fibrosis or strictures claim 1 , cirrhosis claim 1 , atrial fibrosis claim 1 , Crohn's Disease claim 1 , Inflammatory Bowel Disease claim 1 , paralytic ileus claim 1 , arthritis claim 1 , arthrofibrosis claim 1 , and nephrogenic systemic fibrosis.5. The ...

Systems And Methods To Improve Organ Or Tissue Function And Organ Or Tissue Transplant Longevity

The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack. 140-. (canceled)41. A method for the combined administration and monitoring of carbon monoxide (CO) , the method comprising (a) administering CO to a patient or organ , (b) measuring or monitoring CO levels and/or one or more CO markers , and (c) adjusting the CO administration based on the measuring or monitoring of CO levels and/or one or more CO markers.42. The method of claim 41 , wherein the CO is administered to an organ ex vivo.43. The method of claim 42 , wherein the organ is in preservation or storage media comprising about 50 to about 2 claim 42 ,000 ppm CO.44. The method of claim 43 , wherein the media comprises about 50 to about 500 ppm CO.45. The method of claim 42 , wherein gas comprising about 50 ppm to about 2 claim 42 ,000 ppm CO is bubbled into the media.46. The method of claim 45 , further comprising bubbling one or more of O claim 45 , NO or Ninto the media.47. The method of claim 45 , wherein the CO is bubbled into the media before the organ is placed in the media.48. The method of claim 45 , wherein the CO is bubbled into the media when the organ is first placed in the media or shortly thereafter.49. The method of claim 43 , wherein the media comprises one or more of adenine-containing cold preservation buffer claim 43 , lactobionate/raffinose solution or Histidine-Tryptophan Ketoglutarate.50. The method of claim 43 , wherein the media comprises one or more of Celsior® solution claim 43 , Perfadex® ...

AIR TREATMENT SYSTEMS AND METHODS

An air treatment unit may include an air inlet to receive a flow of input air for treatment and a reaction reservoir configured to hold an aqueous air treatment solution. The air treatment unit may also include an air dispersing element flow connected with the air inlet, wherein the air dispersing element is configured to convert at least a portion of the flow of input air into a plurality of microbubbles for introduction into the aqueous air treatment solution, such that an amount of one or more target gas species contained within the plurality of microbubbles is reduced through reaction with the aqueous air treatment solution. The unit may include an air outlet configured to output treated air from the reaction reservoir. 1. An air treatment unit , comprising:an air inlet to receive a flow of input air for treatment;a reaction reservoir configured to hold an aqueous air treatment solution;an air dispersing element flow connected with the air inlet, wherein the air dispersing element is configured to convert at least a portion of the flow of input air into a plurality of microbubbles for introduction into the aqueous air treatment solution, such that an amount of one or more target gas species contained within the plurality of microbubbles is reduced through reaction with the aqueous air treatment solution; andan air outlet configured to output treated air from the reaction reservoir.2. The air treatment unit of claim 1 , wherein the air dispersing element includes a plurality of holes configured to emit the microbubbles.3. The air treatment unit of claim 2 , wherein the plurality of holes have an average diameter of between 0.5 microns and 500 microns.4. The air treatment unit of claim 2 , wherein the plurality holes have an average diameter of between 10 microns and 100 microns.5. The air treatment unit of claim 2 , wherein the plurality of holes are separated from one another by an average distance that is between two times and 30 times an average diameter of ...

SYSTEMS AND METHODS FOR PROMOTING WOUND HEALING

Methods for easing pain and anxiety from atrial or ventricular defibrillation

System and method of administering a pharmaceutical gas to a patient

GAS DELIVERY DEVICE AND SYSTEM

... #$%^&*AU2011328891A120120726.pdf##### 27 ABSTRACT GAS DELIVERY DEVICE A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly 5 with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering 10 gas are also described.

GAS-EVOLVING COMPOSITIONS AND CONTAINER AND DELIVERY SYSTEMS

A gas-evolving composition delivery system is disclosed, which comprises a pressurized container having a dispenser, and a liquid gas-evolving composition, such as an acidified nitrite solution, within the pressurized container, wherein the pressurized container has an internal pressure sufficient to minimize gas production from the gas-evolving composition while within the container. Also disclosed is a method of stabilizing an acidified nitrite solution comprising loading the solution into a container and sealing the container to be airtight.

TRANSVERSELY-ACTIVATED VALVE FOR A THERAPEUTIC VAPORIZER BAG ATTACHMENT SYSTEM

A therapeutic vaporizer inhalation bag attachment system with an integrated valve is disclosed. The attachment system includes a body having a lumen extending between the two openings of the body, a bag coupling, and a valve positioned within the lumen. A method of using the inhalation bag attachment system is also disclosed.

METHOD AND APPARATUS FOR THE ADMINISTRATION OF CO

The present invention relates to a method and apparatus for the administration of carbon monoxide (CO) to a patient. It allows the safe and effective use of carbon monoxide as a medicament.

SYSTEM AND METHOD OF ADMINISTERING A PHARMACEUTICAL GAS TO A PATIENT

A method and system for delivering a pharmaceutical gas to a patient. The method and system provide a known desired quantity of the pharmaceutical gas to the patient independent of the respiratory pattern of the patient. The preferred pharmaceutical gases are CO and NO, both of which are provided as a concentration in a carrier gas. The gas control system determines the delivery of the pharmaceutical gas to the patient to result in the known desired quantity (e.g. in molecules, milligrams or other quantified units) of the pharmaceutical gas being delivered. Upon completion of that known desired quantity of pharmaceutical gas over a plurality of breaths, the system can either terminate any further delivery of the pharmaceutical gas or can activate an alarm to alert the user that the known quantity has been delivered. The system also has alarm functions to alert the user of possible malfunctions of the system.

GAS DELIVERY DEVICE AND SYSTEM

A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gas are also described.

SMOKING APPARATUS AND METHOD

Apparatus consistent with the present disclosure may be a pipe that includes heat transfer materials that have a thermal conductivity of greater than 50 Watts per meter Kelvin. Heat transfer materials may include one or more solid heat sinks (that are rigidly connected to each other or to a portion of the pipe), Peltier devices, or loose fill of a desired size or shape. Fill included in the pipe may also absorb particulate matter or volatile organic compounds. As a user burns or vaporizes materials at one end of the pipe and sucks heated smoke or vapor into the pipe, that user may inhale cool and clean smoke or vapor. Methods and apparatus consistent with the present disclosure may allow a controller at the pipe to send sensor or consumption data to other electronic devices when a number of milligrams of a substance inhaled by a patient are monitored.

System and method of administering a pharmaceutical gas to a patient

ADAPTER, APPARATUS AND METHOD FOR EXHALED BREATH MEASUREMENTS

An adapter (1) for an exhaled breath measurement apparatus (2), comprising a first inlet (3) for tidal breathing, a second inlet (4) for air free from one or more component to be measured, through which and a first one-way valve (5) air flows when a test person inhales through the adapter (1) at the first inlet (3), and an outlet (6) for exhaled breath having a second one-way valve (7). A sample tubing (11) is positioned next to the first inlet (3) for tidal breathing for a continuous sample from the exhaled breath immediately inside the adapter (1), upstream the second one-way valve (7) at the outlet (6) for exhaled breath. An exhaled breath measurement apparatus (2) with such adapter (1). A method for measuring exhaled breath during tidal breathing by sampling continuously in an adapter (1) at a first inlet (3) into which a test person breathes, the sampling taking place upstream of an outlet (6) for exhaled breath.

SYSTEMS AND METHODS TO IMPROVE ORGAN OR TISSUE FUNCTION AND ORGAN OR TISSUE TRANSPLANT LONGEVITY

The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack. 1. A method for improving organ or tissue function or organ or tissue transplant longevity , comprising: administering carbon monoxide (CO)-containing gas a plurality of times to a patient in need of therapy , at a constant alveolar concentration for at least about 30 minutes.2. The method of claim 1 , wherein the patient is a transplant recipient claim 1 , optionally selected from kidney claim 1 , liver claim 1 , lung claim 1 , pancreas claim 1 , heart claim 1 , bone marrow claim 1 , and intestine.3. The method of claim 1 , wherein the patient is experiencing or is at risk of acute rejection claim 1 , chronic allograft rejection claim 1 , vascular rejection claim 1 , or graft versus host disease (GVHD).4. The method of claim 1 , wherein the patient has a condition selected from a chronic kidney fibrosing condition claim 1 , a chronic hepatic fibrosing condition claim 1 , a chronic lung fibrosing conditions claim 1 , myocardial fibrosis claim 1 , pancreatic fibrosis claim 1 , pancreatitis claim 1 , gastrointestinal fibrosis or strictures claim 1 , vascular fibrosis or strictures claim 1 , progressive systemic sclerosis (PSS) claim 1 , scleroderma claim 1 , esophageal fibrosis or strictures claim 1 , cirrhosis claim 1 , atrial fibrosis claim 1 , Crohn's Disease claim 1 , Inflammatory Bowel Disease claim 1 , paralytic ileus claim 1 , arthritis claim 1 , arthrofibrosis claim 1 , and nephrogenic systemic fibrosis.5. The ...

System And Method Of Administering A Pharmaceutical Gas To A Patient

Methods and systems for delivering a pharmaceutical gas to a patient. The methods and systems provide a known desired quantity of the pharmaceutical gas to the patient independent of the respiratory pattern of the patient over a plurality of breaths every nth breath, where n is greater than or equal to 1. The pharmaceutical gases include CO and NO, both of which are provided as a concentration in a carrier gas. The gas control system determines the delivery of the pharmaceutical gas to the patient to result in the known desired quantity (e.g. in molecules, milligrams or other quantified units) of the pharmaceutical gas being delivered. Upon completion of that known desired quantity of pharmaceutical gas over a plurality of breaths, the system can either terminate, continue, activate and alarm, etc.

Method and devices for administration of therapeutic gases

Methods for administering medical gases include providing the medical gas in compressed gas cartridges containing an amount of the medical gas preferably corresponding substantially to a unit dose of the medical gas and providing a patient with access to the medical gas from the gas cartridge upon need therefor. Apparatus for administering medical gases also includes a housing, a cassette associated with the housing containing at least one compressed gas cartridge preferably containing at least an amount of the medical gas substantially as required for a single dose and a patient supply interface to provide the medical gas to the patient.

Gas Delivery Device and System

A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gas are also described.

Devices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery

An indexed drug delivery device comprising a valve assembly comprising a housing and a valve, the valve disposed within the housing, one or more keys integral to the housing, the keys complementary to corresponding openings on a collar, a pressurized canister in fluid communication with the valve assembly, the canister containing an active pharmaceutical ingredient and an. inactive carrier gas, a receiving assembly comprising a receptacle adapted to engage at least a portion of the housing, a seat adapted to engage the valve, and, a plunger assembly adapted to linearly actuate the valve assembly and canister along an axis and to engage the valve and seat, the plunger assembly comprising a carriage fixed to the collar, and, a lever having a cam adapted to engage a spring, the spring adapted to linearly actuate the carriage, valve assembly, canister and collar along the axis. QB5197.0000308318.1 s40 36' 20 34 /,26 34 ...

Gas delivery device and system

GAS DELIVERY DEVICE A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly 5 with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering 10 gas are also described.

SYSTEM AND METHOD FOR CARBON MONOXIDE ATMOSPHERE STORED BLOOD COMPONENTS

A system, apparatus, and method using carbon monoxide for treatment of platelets, and optionally other blood components and/or whole blood, allowing extended storage and increased viability of the stored blood platelets in vivo. The system allows an efficient use of the stored platelets by dividing the platelets into a population with a short residual lifetime for immediate use and a population that can remain in storage for longer. The storage apparatus enables safe platelet preservation and is equipped with an alarm to detect CO leakage.

VENTILATOR

Provided is a ventilator for supplying a mixed gas of oxygen and a medical gas other than oxygen to a patient as an inhalation gas, including a first gas supply device for supplying a gas containing oxygen, an intratracheal tube path inserted and placed in a trachea of the patient, an extratracheal tube path for connecting the first gas supply device with the intratracheal tube path and guiding the gas containing oxygen from the first gas supply device to the patient, and a second gas supply device connected to the extratracheal tube path or the intratracheal tube path for supplying the mixed gas of oxygen and the medical gas other than oxygen to the extratracheal tube path or the intratracheal tube path. Therefore, a ventilator capable of performing effective (artificial) ventilation while reducing a consumption amount of a medical gas other than oxygen is provided.

Gas delivery device and system

A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gas are also described.

Systems and methods to improve organ or tissue function and organ or tissue transplant longevity

The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.

Atemmaske

Atemmaske zur Beatmung eines Patienten, mit einer ringsum laufenden, dem Gesicht des Patienten anlegbaren Kontaktfläche und einer gewölbten Haube, an deren Rand die Kontaktfläche verläuft, und mit einer Einlassöffnung für die dem Patienten zuzuführende Atemluft, dadurch gekennzeichnet, dass die Haube gesichtsnah flach ausgestaltet ist, derart, dass die Atemmaske ein möglichst geringes Volumen zwischen dem Gesicht des Patienten und der Haube einschließt, und dass die Atemmaske eine Auslassöffnung für die vom Patienten ausgeatmete Atemluft aufweist.

Devices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery

Therapeutic gas delivery device with pulsed and continuous flow control

Abstract A therapeutic gas delivery device comprising: an inlet to connect to a source of therapeutic gas; an outlet to connect to a device that introduces the therapeutic gas to a patient; at least one binary control valve in fluid communication with the inlet and outlet that delivers a constant flow of the therapeutic gas; at least one proportional control valve in fluid communication with the inlet and outlet that delivers a variable flow of the therapeutic gas; and a control system that delivers the therapeutic gas through one or more of the binary control valve and the proportional control valve. 0") C>~ -CD oc I Il I-r ...

METHODS AND DEVICES FOR ADMINISTRATION OF THERAPEUTIC GASES

Methods for administering medical gases are disclosed including providing th e medical gas in compressed gas cartridges (210) containing an amount of the medical gas preferably corresponding substantially to a unit dose of the medical gas and providing a patient with means to access the medical gas fro m the gas cartridge upon need therefor. Apparatus for administering medical gases is also disclosed including a housing (300), a cassette (200) associat ed with the housing containing at least one compressed gas cartridge (210) preferably containing at least an amount of the medical gas substantially as required for a single dose and a patient supply interface to provide the medical gas to the patient.

GAS DELIVERY DEVICE AND SYSTEM

A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gas are also described.

SYSTEM OF ADMINISTERING A PHARMACEUTICAL GAS TO A PATIENT

DRUG ADMINISTRATION CONTROLLER

A drug administration controller has a sensor that generates a sensor signal to a physiological measurement device, which measures a physiological parameter in response. A control output responsive to the physiological parameter or a metric derived from the physiological parameter causes a drug administration device to affect the treatment of a person, such as by initiating, pausing, halting or adjusting the dosage of drugs administered to the person.

EXTRACORPOREAL PHOTODYNAMIC BLOOD ILLUMINATION (IRRADIATION) CELL FOR THE TREATMENT OF CARBON MONOXIDE POISONING

An exposure cell and method for treatment of carbon monoxide poisoning in the blood of a living body by removal of a portion of blood from the body, placing the portion in the exposure cell, exposing the portion in the cell to light of wave length and intensity that causes dissociation of carbon monoxide from hemoglobin, and returning the portion to the body. The exposure cell has an exposure zone outside of the body, that holds the portion, and a window that allows light from outside the zone to enter the zone to disassociate carbon monoxide from the portion. Oxygen is injected into the zone and carbon monoxide is removed from the zone. 1. An exposure cell for treatment of carbon monoxide poisoning in the blood of a living body by removal of a portion of blood from the body , placing the portion in the exposure cell , exposing the portion in the cell to light of wave length and intensity that causes dissociation of carbon monoxide from hemoglobin , and returning the portion to the body , comprising:a.) a light source;b.) an exposure cell that has an exposure zone outside of the body, that holds the portion, and a window that allows light from the light source, outside the zone. to enter the zone to disassociate carbon monoxide from the portion;c.) an oxygen injector that injects oxygen into the zone; andd.) a carbon monoxide extractor that removes carbon monoxide from the zone.2. A method of treatment of carbon monoxide poisoning in the blood of a living body , comprising the steps of:a.) removing a portion of blood from the body,b.) placing the portion in an exposure cell,c.) exposing the portion in the cell to light of wave length and intensity that causes dissociation of carbon monoxide from hemoglobind.), removing the dissociated carbon monoxide from the cell, ande.) returning the portion, with reduced carbon, monoxide to the body. This invention has been created without the sponsorship or funding of any federally sponsored research or development program.This ...

Devices And Methods For Engaging Indexed Valve And Pressurized Canister Assembly With Collar And For Linear Actuation By Plunger Assembly Into Fluid Communication With Device For Regulating Drug Delivery

An indexed drug delivery device (70) comprising a valve assembly (13) comprising a housing (26) and a valve, the valve disposed within the housing, one or more keys (34,38) integral to the housing, the keys complementary to corresponding openings on a collar (12), a pressurized canister (28) in fluid communication with the valve assembly, the canister containing an active pharmaceutical ingredient and an inactive carrier gas, a receiving assembly comprising a receptacle adapted to engage at least a portion of the housing, a seat adapted to engage the valve, and, a plunger assembly adapted to linearly actuate the valve assembly and canister along an axis and to engage the valve and seat, the plunger assembly comprising a carriage fixed to the collar, and, a lever having a cam adapted to engage a spring, the spring adapted to linearly actuate the carriage, valve assembly, canister and collar along the axis.

VACCINE AND HEALTH-RELATED APPLICATIONS FOR RUMINANT BREATH MONITORING SYSTEM

A method for managing health of ruminants or other animals. The method includes providing a feed dispenser for feeding ruminants nutrient supplements, and the feed dispenser includes a gas analyzer where a ruminant places its head. The method includes determining a particular ruminant has accessed the feed dispenser such as by reading an identifier from an RFID ear tag and operating the feed dispenser to provide a ration of methane-controlling nutrient supplement. The method may include using the identifier to determine that the animal should be vaccinated such as based on their age and no record of prior vaccination. The method includes dispensing a dose of a nasal vaccine into the feed dispenser near the animal's nostrils. The method may include discharging a diagnostic agent such as propane or carbon monoxide and processing data collected to diagnose the animal as having a disease or condition such as a lung-related sickness.

Smoking apparatus and method

Apparatus consistent with the present disclosure may be a pipe that includes heat transfer materials that have a thermal conductivity of greater than 50 Watts per meter Kelvin. Heat transfer materials may include one or more solid heat sinks (that are rigidly connected to each other or to a portion of the pipe), Peltier devices, or loose fill of a desired size or shape. Fill included in the pipe may also absorb particulate matter or volatile organic compounds. As a user burns or vaporizes materials at one end of the pipe and sucks heated smoke or vapor into the pipe, that user may inhale cool and clean smoke or vapor. Methods and apparatus consistent with the present disclosure may allow a controller at the pipe to send sensor or consumption data to other electronic devices when a number of milligrams of a substance inhaled by a patient are monitored.

BREATHING CONTROL USING HIGH FLOW RESPIRATION ASSISTANCE

High flow therapy is used to treat Cheyne-Stokes respiration and other types of periodic respiration disorders by periodic application of high flow therapy, 5 adjustment of high flow therapy flow rates and/or periodic additions of C02 or 02 into the air flow provided to the patient. -31-

Nasal Flushing Catheter

A nasal flushing catheter, made of silicone latex, thermoplastic elastomer or other soft and elastic material, can be operated by the patients. The catheter has a closed end and an open end on the opposite side. There are multiple side-holes near the closed end. This catheter, when adapted to a connector and further connected to a syringe, can eject multiple strong thin spouts within the nasal cavity and nasopharynx for cleansing mucus and crust. The catheter may contain at least one stylet to improve its controllability. By a given injection rate of 10 cc/sec using a syringe, the average vertical height of spouts can be predicted by the total area of side-holes, the catheter is therefore classified as following: 1. a low pressure catheter, having 3.367 mm2˜4.123 mm2 of total areas of side-holes to eject 30 to 45 cm spouts; 2. a medium pressure catheter, having 2.381 mm2˜3.367 mm2 of total area of side-holes to eject 45 to 90 cm spouts and 3. a high pressure catheter, having less than 2.381 ...

TRANSVERSELY-ACTIVATED VALVE FOR A THERAPEUTIC VAPORIZER BAG ATTACHMENT SYSTEM

A therapeutic vaporizer inhalation bag attachment system with an integrated valve is disclosed. The attachment system includes a body having a lumen extending between the two openings of the body, a bag coupling, and a valve positioned within the lumen. A method of using the inhalation bag attachment system is also disclosed. 1. A therapeutic vaporizer inhalation bag attachment system with an integrated valve , comprising:a body comprising a lumen extending between a first opening at a first end of the body and a second opening at a second end of the body;a bag coupling configured to attach an inhalation bag to the second end of the body; anda duck-bill valve positioned within the lumen and configured to move between a first position which allows flow of vapor through the lumen in a first direction extending from the first opening to the second opening, and a second position which prevents substantial flow of vapor through the lumen in a second direction from the second opening to the first opening, the valve comprising two flaps extending within the lumen inwardly from an inner sidewall of the body, wherein a distal end of the flaps form a seal to prevent the substantial flow of vapor in the second flow direction.2. The attachment system of claim 1 , wherein the flaps extend from the inner sidewall of the body in the first direction at a non-orthogonal angle.3. The attachment system of claim 1 , wherein the valve is configured to move to the first position and allow flow in the second direction when a protrusion is extended through the first opening and through the distal end of the flaps and automatically return to the second position when the protrusion is removed from the first opening.4. The attachment system of claim 3 , wherein the body includes a lip seal extending from an inner wall of the body into the lumen claim 3 , the lip seal configured to engage with the protrusion when the protrusion is extended through the first opening.5. The attachment system of ...

Gas delivery device and system

System and method for controlling gas composition in a surgical cavity during endoscopic surgical procedures

A method for controlling gas composition in a surgical cavity during an endoscopic surgical procedure includes monitoring for a plurality of gas species in a gas flow from a surgical cavity of a patient. The method includes measuring the plurality of gas species in the gas flow from the surgical cavity and determining if the gas species measured in the gas flow from the surgical cavity are each present and/or within a respective desired range. The method includes adding gas into the surgical cavity if one or more gas species in the plurality of gas species is outside of the respective desired range so as to bring a composition of gas species in the surgical cavity within the respective desired range.

Gas Delivery Device And System

A gas delivery system including a gas delivery device (100), a control module (200) and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve (107) assembly with a valve and circuit including a memory (134), a processor (122) and a transceiver (120) in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator (400) and a breathing circuit (410). Methods of administering gas are also described.

SYSTEM AND METHOD FOR CARBON MONOXIDE ATMOSPHERE STORED BLOOD COMPONENTS

A system, apparatus, and method using carbon monoxide for treatment of platelets, and optionally other blood components and/or whole blood, allowing extended storage and increased viability of the stored blood platelets in vivo. The system allows an efficient use of the stored platelets by dividing the platelets into a population with a short residual lifetime for immediate use and a population that can remain in storage for longer. The storage apparatus enables safe platelet preservation and is equipped with an alarm to detect CO leakage. 1) A platelet storage device comprising:a) a core container adapted for extended storage of platelets, wherein said adaptation comprises a COatm inside said core container, wherein said core container is adapted to be closed so that it is gas impermeable; andb) an outer container for storing said core container, wherein said outer container is adapted to be closed so that it is gas impermeable.2) (canceled)3) The platelet storage device of wherein said COatm comprises up to 100% carbon monoxide.4) The platelet storage device of wherein said COatm further comprises another gas such as xenon.5) (canceled)6) The platelet storage device of wherein said outer container comprises an inert gas.7) The platelet storage device of wherein said outer container comprises a CO alarm.8) A method of storing platelets claim 1 , comprising:a) inserting the platelets into a core container, wherein the core container comprises a COatm inside the core container, wherein the core container is adapted to be closed so that it is gas impermeable;b) treating said platelets by replacing air in said core container with CO and sealing said core container;c) placing said core container into an outer container wherein the outer container is adapted to be closed so that it is gas impermeable; andd) sealing said outer container.9) The method of further comprising:a) opening said outer container;b) opening said core container to allow escape of said COatm; andc) ...

Systems and methods to improve organ function and organ transplant longevity

The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ function, thereby increasing the lifespan of transplanted organs, or slowing the decline of native organs, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack.

Modular Extracorporeal Systems and Methods for Treating Blood-Borne Diseases

Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.

EXTRACORPOREAL PHOTODYNAMIC BLOOD ILLUMINATION (IRRADIATION) FOR THE TREATMENT OF CARBON MONOXIDE POISONING

Treatment of carbon monoxide poisoning of a body by removal of a portion of the blood from the body, placing the portion in an exposure cell, exposing the portion in the cell to light of wave length and intensity that causes dissociation of carbon monoxide from hemoglobin, and returning the portion to the body. The intensity and wave length of the light is sufficient to dissociate a therapeutically-effective amount of carbon monoxide from the hemoglobin in the blood. The blood is circulated from and to the body through a concentric double lumen cannula. The wave lengths of the light are 540 and/or 570 nanometers. The cell exposes the blood to at least 9.5 Joules of dissociative light per milliliter of blood, and least 9.5 Watts of dissociative light per milliliter of blood per second. Oxygen is provided to, and the dissociated carbon monoxide is removed from the system. 1. A system for treatment of carbon monoxide poisoning of the blood of a living victim , comprising:a. an exposure cell,b. a first sub-system adapted to remove a portion of the blood from the victim and to place the portion in the exposure cell,c. a second sub-system adapted to expose the portion in the cell to dissociative light that causes dissociation of carbon monoxide from hemoglobin, andd. a third sub-system adapted to return the portion to the victim.2. A system as recited in claim 1 , wherein the dissociative light is of a wave length selected from the group of 540 and 570 nanometers and combinations thereof.3. A system as recited in claim 1 , wherein the dissociative light is of a intensity of at least 9.5 Joules per milliliter of blood.4. A system as recited in claim 1 , wherein the dissociative light is of a intensity of at least 9.5 Watts per milliliter of blood flow per second.5. A system as recited in claim 1 , wherein the first and third sub-systems are a concentric double lumen cannula.6. A system as recited in claim 1 , wherein the system includes a subsystem that injects oxygen into ...

Gas delivery device and system

A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gas are also described.

Modular Extracorporeal Systems and Methods for Treating Blood-Borne Diseases

Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.

SYSTEMS ANDMETHODS TO IMPROVE ORGANOR TISSUE FUNCTION ANDORGANOR TISSUE TRANSPLANT LONGEVITY

The present invention provides for systems and methods for inhaled CO therapy to prevent, attenuate, or delay processes that accelerate the loss of organ or tissue function, thereby increasing the lifespan of transplanted organs or tissues, or slowing the decline of native organs or tissues, or delaying the need for replacement of diseased native organs with organ transplants. Such biological processes that are prevented, attenuated, or delayed include chronic persistent inflammation, fibrosis, scarring, as well as immunologic or autoimmune attack. 1. A method for improving organ or tissue function or organ or tissue transplant longevity , comprising: administering carbon monoxide (CO)-containing gas a plurality of times to a patient in need of therapy , at a constant alveolar concentration for at least about 30 minutes.2. The method of claim 1 , wherein the patient is a transplant recipient claim 1 , optionally selected from kidney claim 1 , liver claim 1 , lung claim 1 , pancreas claim 1 , heart claim 1 , bone marrow claim 1 , and intestine.3. The method of or claim 1 , wherein the patient is experiencing or is at risk of acute rejection claim 1 , chronic allograft rejection claim 1 , vascular rejection claim 1 , or graft versus host disease (GVHD).4. The method of or claim 1 , wherein the patient has a condition selected from a chronic kidney fibrosing condition claim 1 , a chronic hepatic fibrosing condition claim 1 , a chronic lung fibrosing conditions claim 1 , myocardial fibrosis claim 1 , pancreatic fibrosis claim 1 , pancreatitis claim 1 , gastrointestinal fibrosis or strictures claim 1 , vascular fibrosis or strictures claim 1 , progressive systemic sclerosis (PSS) claim 1 , scleroderma claim 1 , esophageal fibrosis or strictures claim 1 , cirrhosis claim 1 , atrial fibrosis claim 1 , Crohn's Disease claim 1 , Inflammatory Bowel Disease claim 1 , paralytic ileus claim 1 , arthritis claim 1 , arthrofibrosis claim 1 , and nephrogenic systemic fibrosis.5. The ...

THERAPEUTIC VAPORIZER

A therapeutic vaporizer is disclosed having two or more housing portions configured to form an inner cavity. The housing portions are movable between an open and closed position, such that at least a portion of the inner cavity is enclosed when the housing portions are in the closed position. The vaporizer includes at least one accessory-receiving element configured to receive at least one accessory within the inner cavity when the housing portions are in the closed position. 166-. (canceled)67. A therapeutic vaporizer , comprising:a housing;a gas flow device contained within the housing;a heater contained within the housing, the heater comprising a chamber and a heating element configured to selectively heat a gas flowed from the gas flow device and through the chamber; an inner bowl cavity comprising a first therapeutic material support configured for supporting a vaporizable material;', 'an inlet providing fluid communication between the inner bowl cavity and the chamber, and', 'an outlet providing fluid communication from the inner bowl cavity;, 'a bowl comprisingan intermediary conduit positioned between the heater and the bowl, the heater in fluid communication with the bowl via the intermediary conduit;a first temperature sensor configured to detect a first temperature proximate to or within a portion of the heater;a second temperature sensor configured to detect a second temperature proximate to or within a fluid pathway formed downstream of the heater;a temperature controller electrically connected to the first and the second temperature sensors and the heating element for controlling the temperature of a gas flowed through the bowl cavity; anda second therapeutic material support positioned proximate to the outlet of the bowl, the second therapeutic material support formed as a tray, a basin, a receptacle or another container configured to support an aromatic material selected from an oil, a liquid, a gel, a solid or a semi-solid material.68. The ...

Devices And Methods For Engaging Indexed Valve And Pressurized Canister Assembly With Collar And For Linear Actuation By Plunger Assembly Into Fluid Communication With Device For Regulating Drug Delivery

A valve assembly comprising a housing and a valve, the valve being disposed within the housing, a first indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member, and a radio frequency identification device adapted to communicate with a radio frequency receiver, the valve being configured to align with a canister, seal the canister and open in a single movement. A drug containment device having said valve assembly is also disclosed. 1. A valve assembly comprising:a housing and a valve, the valve being disposed within the housing;a first indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member; anda radio frequency identification device adapted to communicate with a radio frequency receiver,wherein the valve is configured to align with a canister, seal the canister and open in a single movement.2. A drug containment device comprising:a valve assembly comprising a housing and a valve disposed within the housing, a first indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member,a canister in fluid communication with the valve assembly, the canister containing an active pharmaceutical ingredient and,a radio frequency identification device adapted to communicate with a radio frequency receiver,wherein the valve is configured to align with the canister, seal the canister and open in a single movement.3. The valve assembly of claim 1 , wherein the radio frequency identification device is adapted to communicate to the radio frequency receiver identifying information of the contents of a canister that is attachable to the valve.4. The valve assembly of claim 1 , wherein the valve assembly is attachable to a canister comprising an active pharmaceutical ingredient including one of nitric oxide claim 1 , with a concentration in the range of approximately 50 ppm to 10 claim 1 ,000 ppm claim 1 , ...

System And Method Of Administering A Pharmaceutical Gas To A Patient

Methods and systems for delivering a pharmaceutical gas to a patient. The methods and systems provide a known desired quantity of the pharmaceutical gas to the patient independent of the respiratory pattern of the patient over a plurality of breaths every nbreath, where n is greater than or equal to 1. The pharmaceutical gases include CO and NO, both of which are provided as a concentration in a carrier gas. The gas control system determines the delivery of the pharmaceutical gas to the patient to result in the known desired quantity (e.g. in molecules, milligrams or other quantified units) of the pharmaceutical gas being delivered. Upon completion of that known desired quantity of pharmaceutical gas over a plurality of breaths, the system can either terminate, continue, activate and alarm, etc. 1. A method of administering a pharmaceutical gas to a patient , wherein the pharmaceutical gas comprises at least one of nitric oxide or carbon monoxide , the method comprising:delivering a first quantity of the pharmaceutical gas to the patient in a first breath;monitoring the patient's respiratory rate or changes in the patient's respiratory rate;varying the quantity of pharmaceutical gas delivered to the patient in one or more subsequent breaths based on the monitored respiratory rate or changes in the patient's respiratory rate.2. The method of claim 1 , wherein the quantity delivered in the subsequent breath is greater than the first quantity in response to a decrease in the patient's respiratory rate.3. The method of claim 1 , wherein the quantity delivered in the subsequent breath is less than the first quantity in response to an increase in the patient's respiratory rate.4. The method of claim 1 , wherein varying the quantity of pharmaceutical gas delivered to the patient avoids high unsafe doses or doses too low to be effective.5. The method of claim 1 , wherein the pharmaceutical gas is delivered to the patient every breath.6. The method of claim 1 , wherein the ...

OXYGEN-CHARGED IMPLANTABLE MEDICAL DEVICES FOR AND METHODS OF LOCAL DELIVERY OF OXYGEN VIA OUTGASSING

Oxygen-charged (or oxygen-rich) implantable medical devices for and methods of local delivery of oxygen via outgassing is disclosed. The presently disclosed oxygen-charged implantable medical devices are, for example, polymeric implants that are functionalized to locally deliver oxygen from the implant surface for prolonged periods of time, thus increasing rates of healing and reducing rates of infection as compared with conventional medical implant devices. 1. An implantable medical device comprising one or more gases dissolved in one or more materials.2. The implantable medical device of claim 1 , comprising one or more gases dissolved in one or more polymeric materials.3. The implantable medical device of claim 2 , wherein the one or more polymeric materials are functionalized.4. The implantable medical device of claim 1 , wherein the material is hyperbarically-charged with one or more gases.5. The implantable medical device of claim 2 , wherein the one or more polymeric materials is selected from the group consisting of polyvinyl alcohol (PVA) claim 2 , polylactic acid (PLA) claim 2 , ethylene vinyl alcohol (EVOH) claim 2 , poly(lactide-co-glycolide) (PLGA) claim 2 , polyglycolide (PGA) claim 2 , nylon claim 2 , polyketone claim 2 , polyether ether ketone (PEEK) claim 2 , polyethylene terephthalate (PET) claim 2 , polyvinylidine chloride (PVDC) claim 2 , polyacrylonitrile (PAN) claim 2 , polyamides (PAs) claim 2 , polyvinyl chloride (PVC) claim 2 , polyvinylidene fluoride (PVDF) claim 2 , polyethylenimine (PEI) claim 2 , polycarbonate (PC) claim 2 , ethylene chlorotrifluoroethylene (ECTFE) claim 2 , polyethylene naphthalene (PEN) claim 2 , polytrimethylene terephthalate (PTT) claim 2 , liquid crystal polymers (e.g. claim 2 , Kevlar) claim 2 , nanocellulose claim 2 , poly(methylmethacrylate (PMMA) claim 2 , polybutylene terephthalate (PBT) claim 2 , poly(p-xylylene) claim 2 , and derivatives thereof.6. The implantable medical device of claim 1 , wherein the one ...

Systems And Methods Of Administering A Pharmaceutical Gas To A Patient

Methods and systems for delivering a pharmaceutical gas to a patient. The methods and systems provide a known desired quantity of the pharmaceutical gas to the patient independent of the respiratory pattern of the patient over a plurality of breaths every nbreath, where n is greater than or equal to 1. The pharmaceutical gases include CO and NO, both of which are provided as a concentration in a carrier gas. The gas control system determines the delivery of the pharmaceutical gas to the patient to result in the known desired quantity (e.g. in molecules, milligrams or other quantified units) of the pharmaceutical gas being delivered. Upon completion of that known desired quantity of pharmaceutical gas over a plurality of breaths, the system can either terminate, continue, activate and alarm, etc. 1. A method of administering a pharmaceutical gas to a patient , wherein the pharmaceutical gas comprises at least one of nitric oxide or carbon monoxide , the method comprising:delivering a first quantity of the pharmaceutical gas to the patient in a first breath;monitoring the patient's respiratory rate or changes in the patient's respiratory rate;varying the quantity of pharmaceutical gas delivered to the patient in one or more subsequent breaths based on the monitored respiratory rate or changes in the patient's respiratory rate.2. The method of claim 1 , wherein the quantity delivered in the subsequent breath is greater than the first quantity in response to a decrease in the patient's respiratory rate.3. The method of claim 1 , wherein the quantity delivered in the subsequent breath is less than the first quantity in response to an increase in the patient's respiratory rate.4. The method of claim 1 , wherein varying the quantity of pharmaceutical gas delivered to the patient avoids high unsafe doses or doses too low to be effective.5. The method of claim 1 , wherein the pharmaceutical gas is delivered to the patient every breath.6. The method of claim 1 , wherein the ...

DRUG ADMINISTRATION CONTROLLER

A drug administration controller has a sensor that generates a sensor signal to a physiological measurement device, which measures a physiological parameter in response. A control output responsive to the physiological parameter or a metric derived from the physiological parameter causes a drug administration device to affect a treatment of a person, such as by initiating, pausing, halting or adjusting a dosage of drugs administered to the person. 1. A drug administration method comprising:measuring a physiological parameter in response to a sensor attached to a patient;deriving a metric corresponding to the physiological parameter; andcontrolling a drug administration device based upon the metric, the metric being a number of cyclical desaturations over a given timeframe greater than a predetermined threshold.2. The drug administration method of claim 1 , further comprising measuring the physiological parameter using a pulse oximeter.3. The drug administration method of claim 1 , further comprising controlling the drug administration based upon the metric and a measure of perfusion index.4. The drug administration method of claim 3 , further comprising controlling the drug administration based on a carboxyhemoglobin measurement. The present application is a divisional of U.S. patent application Ser. No. 15/094,100, filed Apr. 8, 2016, entitled Drug Administration Controller, which is a divisional of U.S. patent application Ser. No. 13/475,136, filed May 18, 2012, entitled Drug Administration Controller, which is a continuation of U.S. patent application Ser. No. 11/654,904, filed Jan. 17, 2007, entitled Drug Administration Controller, which claims priority benefit under 35 U.S.C. § 119(e) to U.S. Provisional Patent Applications Ser. No. 60/759,673, filed Jan. 17, 2006, entitled Drug Administration Controller, and Ser. No. 60/764,946, filed Feb. 2, 2006, entitled Drug Administration Controller, all of which are incorporated by reference herein in their entireties. ...

Transversely-activated valve for a therapeutic vaporizer bag attachment system

A therapeutic vaporizer inhalation bag attachment system with an integrated valve is disclosed. The attachment system includes a body having a lumen extending between the two openings of the body, a bag coupling, and a valve positioned within the lumen. A method of using the inhalation bag attachment system is also disclosed.

Bi-Directional Oxygenation Apparatus for a Non-Intubated Patient

A self-administered oxygenation apparatus for increasing pressure within a non-intubated patient's lungs and thereby increasing an amount of oxygen in the non-intubated patient's blood when operated by the patient includes a mouthpiece, a vent member, a resistance member, and a plurality of medical sensors. The medical sensors are configured to receive a portion of the exhalation and to transmit generated medical data to a remote location, such as to a software application via the internet. The mouthpiece includes an external portion through which the patient inhales and exhales. The resistance member is a PEEP valve configured to open upon inhalation so as to allow ambient air inhaled by the patient to pass thereby without resistance and to close upon exhalation, exhalation causing an end shield to pivot outwardly from the vent member under a bias of external elastic members.

CONTROLLED OUTGASSING OF HYBERBARICALLY LOADED MATERIALS FOR THE DELIVERY OF OXYGEN AND OTHER THERAPEUTIC GASES IN BIOMEDICAL APPLICATIONS

Devices and methods for delivering oxygen and other therapeutic gases to a target, such as a tissue, a tissue-engineered construct, and a wound, in a controlled and sustained manner are disclosed. 1. A microtank for delivering one or more gases in a controlled and sustained manner , the microtank comprising one or more vessels , wherein the one or more vessels have a volume defined by at least one gas barrier and/or a means for mechanical support/confinement , wherein the volume of the one or more vessels is capable of being loaded with one or more gases at an atmospheric or a hyperbaric pressure and subsequently releasing the one or more gases in a controlled and sustained manner.2. The microtank of claim 1 , wherein the gas barrier and/or means for mechanical support/confinement comprises a material selected from the group consisting of polyvinyl alcohol (PVOH) claim 1 , ethylene vinyl alcohol (EVOH) claim 1 , polyethylene terephthalate (PET) claim 1 , polycaprolactone (PCL) claim 1 , poly(lactic-co-glycolic acid) (PLGA) claim 1 , poly(lactic acid) (PLA) claim 1 , poly(glycolic acid) (PGA) claim 1 , a biocompatible polymer claim 1 , a silica coating claim 1 , a metal coating claim 1 , a ceramic claim 1 , and combinations thereof.3. The microtank of claim 1 , wherein the one or more vessels have a dimension ranging from about 1 nanometer to about 1000 micrometers.4. The microtank of claim 3 , wherein the one or more vessels have a dimension ranging from about 1 micrometer to about 1000 micrometers.5. The microtank of claim 1 , further comprising one or more gases loaded in the volume of the one or more vessels under pressure in a hyperbaric environment.6. The microtank of claim 5 , further comprising one or more gases loaded in the volume of the one or more vessels at a temperature having a range from below 0° C. up to a limiting combustion temperature of the one or more gases or a material comprising the microtank.7. The microtank of claim 6 , further comprising ...

Breathing control using high flow respiration assistance

High flow therapy is used to treat Cheyne-Stokes respiration and other types of periodic respiration disorders by periodic application of high flow therapy, adjustment of high flow therapy flow rates and/or periodic additions of CO2 or O2 into the air flow provided to the patient.

Implantable heart treatment systems, devices, and methods

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; and an oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion.

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate; an electromagnetic signal generator configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; a metabolic molecule supply device configured to supply one or more metabolic molecules to one or more tissues of the heart; and control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, dependent upon a status of a ventricular fibrillation event of the heart. 143.-. (canceled)44. A method of treating a heart with an implanted heart treatment device , comprising:generating, via a heart treatment device implanted within a body of a biological subject, one or more electric signals configured to stimulate one or more tissues of a heart within a body during a fibrillation event of the heart according to a first control protocol and a second control protocol;administering the one or more electric signals to the one or more tissues of the heart according to the first control protocol and the second control protocol; anddelivering, via the heart treatment device, one or more metabolic molecules to one or more tissues of the heart, after the fibrillation event has proceeded for a duration sufficient to exhaust the myoglobin-based oxygen of the heart according to the second control protocol.45. The method of claim 44 , wherein the one or more metabolic molecules include one or more oxygenated molecules.46. The method of claim 44 , wherein the one or more metabolic molecules include iodide or salts thereof.47. The method of claim 44 , further comprising:storing the one or more metabolic molecules in the heart treatment device in vivo.48. The method of claim 44 , wherein generating ...

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; and an energy-carrier molecule delivery device coupled to the substrate and configured to supply one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body. 143.-. (canceled)44. A method of treating a heart with an implanted heart treatment device , comprising:generating, via a heart treatment device implanted within a body of a biological subject, one or more electric signals configured to stimulate one or more tissues of a heart within a body during a fibrillation event of the heart;administering the one or more electric signals to the one or more tissues of the heart; anddelivering, via the heart treatment device, one or more non-oxygen cellular energy sources to one or more tissues of the heart, after the fibrillation event has proceeded for a duration sufficient to exhaust the myoglobin-based oxygen of the heart.45. The method of claim 44 , wherein the one or more non-oxygen cellular energy sources include at least one of adenosine triphosphate (ATP) claim 44 , cyclic adenosine monophosphate (cAMP) claim 44 , adenosine monophosphate (AMP) claim 44 , adenosine diphosphate (ADP) claim 44 , creatine claim 44 , and cyclocreatine.4648.-. (canceled)49. The method of claim 44 , further comprising:storing the one or more non-oxygen cellular energy sources molecules in vivo.50. The method of claim 44 , further comprising:storing the one or more non-oxygen cellular energy sources in a reservoir of the heart treatment device.51. The method of claim 44 , wherein the one or more more non-oxygen cellular energy sources are positioned within one or more carrier ...

Gas Delivery Device And System

A gas delivery system including a gas delivery device, a control module and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line-of-sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator and a breathing circuit. Methods of administering gas are also described.

Medical Carbon Monoxide Delivery System

A medical carbon monoxide generator provides for a solid carbon material that may be heated at substantially normal atmospheric pressure to provide a source of medical quality carbon monoxide. The heating source may be an electrical filament or laser controllable by a microcontroller to provide accurate delivery rates and amounts. In one embodiment, a replaceable cartridge holding the carbon material may be used. 1. An organ transplant container system comprising:an insulated container for receiving a transplant organ held in a storage liquid; anda carbon monoxide generator attached to the insulated container and communicating with the storage liquid to provide a source of carbon monoxide to the storage liquid by heating a carbon source in atmospheric pressure air.2. The organ transplant container system of including a scrubber element communicating with the storage liquid to vent gas from the storage liquid into the scrubber element and to scrub carbon monoxide from the vented gas.3. The organ transplant container system of wherein the carbon monoxide generator provides:a reaction chamber holding a source of carbon monoxide communicating with the storage liquid in a reaction chamber holding a purified carbon element and providing an ingress port and egress port;a pump communicating with the ingress port to provide a source of air passing into the reaction chamber and out of the egress port;an electrically controllable heater element heating the purified carbon element to generate carbon monoxide gas from the reaction of the heated purified carbon with the air of the reaction chamber; anda respiratory delivery appliance communicating with the egress port to provide carbon monoxide to a patient for respiration thereof.4. The organ transplant container system of wherein the purified carbon element is at least USP grade pure carbon.5. The organ transplant container system of wherein the electrically controllable heater element is an ohmic resistor in thermal ...

Device for Discharging Toxic Gases

A device for reducing the concentration of a gas from a gas source is described. The device includes a housing having a proximal end, a distal end and a length therebetween that at least partially encloses an interior region, wherein the proximal end has a gas inlet connectable to a gas source, and the distal end has a diluted gas outlet, a nozzle having at least one gas outlet, wherein the nozzle extends within the interior region of the housing, and wherein the nozzle gas outlet is fluidly connected to the housing gas inlet such that gas entering the housing gas inlet exits through the nozzle gas outlet, and at least one opening in the housing length, wherein the opening is adjacent to the at least one nozzle gas outlet and permits air to enter the housing interior region near the nozzle gas outlet. The device is incorporated into a gas delivery assembly, whereby excess gas can be safely purged from the assembly at a diluted concentration via the device. 1. A device for reducing the concentration of a gas from a gas source , comprising:a housing having a proximal end, a distal end and a length therebetween that at least partially encloses an interior region, wherein the proximal end has a gas inlet connectable to a gas source, and the distal end has a diluted gas outlet;a nozzle having at least one gas outlet, wherein the nozzle extends within the interior region of the housing, and wherein the nozzle gas outlet is fluidly connected to the housing gas inlet such that gas entering the housing gas inlet exits through the nozzle gas outlet; andat least one opening in the housing length, wherein the opening is adjacent to the at least one nozzle gas outlet and permits air to enter the housing interior region near the nozzle gas outlet.2. The device of claim 1 , wherein the gas from the gas source is diluted to about 5% or less of its original concentration.3. A method for purging a pressurized gas from a gas delivery device claim 1 , comprising directing a flow of ...

Devices And Methods For Engaging Indexed Valve And Pressurized Canister Assembly With Collar And For Linear Actuation By Plunger Assembly Into Fluid Communication With Device For Regulating Drug Delivery

A valve assembly comprising a housing and a valve, the valve being disposed within the housing, a first indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member, and a radio frequency identification device adapted to communicate with a radio frequency receiver, the valve being configured to align with a canister, seal the canister and open in a single movement. A drug containment device having said valve assembly is also disclosed. 1. A valve assembly comprising:a housing and a valve, the valve being disposed within the housing;a first indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member; anda radio frequency identification device adapted to communicate with a radio frequency receiver,wherein the valve is configured to align with a canister, seal the canister and open in a single movement.2. A drug containment device comprising:a valve assembly comprising a housing and a valve disposed within the housing, a first indexed member integral to the housing, the first indexed member adapted to be complementary to a second indexed member,a canister in fluid communication with the valve assembly, the canister containing an active pharmaceutical ingredient and,a radio frequency identification device adapted to communicate with a radio frequency receiver,wherein the valve is configured to align with the canister, seal the canister and open in a single movement.3. The valve assembly of claim 1 , wherein the radio frequency identification device is adapted to communicate to the radio frequency receiver identifying information of the contents of a canister that is attachable to the valve.4. The valve assembly of claim 1 , wherein the valve assembly is attachable to a canister comprising an active pharmaceutical ingredient including one of nitric oxide claim 1 , with a concentration in the range of approximately 50 ppm to 10 claim 1 ,000 ppm claim 1 , ...

Treatment gas supplying apparatus

A treatment gas supplying apparatus includes: a first mixed gas producing section that is configured to produce a first mixed gas in which a first gas and a treatment gas having a treatment effect are mixed with each other in a first ratio; and a second mixed gas producing section that is configured to produce a second mixed gas in which a second gas and the treatment gas are mixed with each other in a second ratio, the second ratio being within a constant difference from the first ratio.

Systems And Methods Of Administering A Pharmaceutical Gas To A Patient

Methods and systems for delivering a pharmaceutical gas to a patient. The methods and systems provide a known desired quantity of the pharmaceutical gas to the patient independent of the respiratory pattern of the patient over a plurality of breaths every nbreath, where n is greater than or equal to 1. The pharmaceutical gases include CO and NO, both of which are provided as a concentration in a carrier gas. The gas control system determines the delivery of the pharmaceutical gas to the patient to result in the known desired quantity (e.g. in molecules, milligrams or other quantified units) of the pharmaceutical gas being delivered. Upon completion of that known desired quantity of pharmaceutical gas over a plurality of breaths, the system can either terminate, continue, activate and alarm, etc. 1. A method of administering a pharmaceutical gas to a patient , wherein the pharmaceutical gas comprises at least one of nitric oxide or carbon monoxide , the method comprising:delivering a first quantity of the pharmaceutical gas to the patient in a first breath;monitoring the patient's respiratory rate or changes in the patient's respiratory rate;varying the quantity of pharmaceutical gas delivered to the patient in one or more subsequent breaths based on the monitored respiratory rate or changes in the patient's respiratory rate.2. The method of claim 1 , wherein the quantity delivered in the subsequent breath is greater than the first quantity in response to a decrease in the patient's respiratory rate.3. The method of claim 1 , wherein the quantity delivered in the subsequent breath is less than the first quantity in response to an increase in the patient's respiratory rate.4. The method of claim 1 , wherein varying the quantity of pharmaceutical gas delivered to the patient avoids high unsafe doses or doses too low to be effective.5. The method of claim 1 , wherein the pharmaceutical gas is delivered to the patient every breath.6. The method of claim 1 , wherein the ...

SYSTEM AND METHOD FOR PHOTOTHERAPY FOR PREVENTING OR TREATING CARBON MONOXIDE POISONING

Systems and methods are provided for treating or preventing carbon monoxide poisoning. In particular, systems and methods are provided for a phototherapy treatment or prevention system that delivers light radiation to a patient's body to photodissociate carbon monoxide from hemoglobin. 1. A phototherapy system for treating or controlling an amount of carbon monoxide poisoning in a patient , comprising:a light source in communication with an aerosolizing element; anda tube configured to provide communication between the light source and an airway, the airway configured to provide communication to at least one of a nose and a mouth of the patient,wherein the aerosolizing element is configured to aerosolize the light source to deliver the light source to the patient by ventilation of gas through the airway.2. The phototherapy system of claim 1 , wherein the light source is configured to emit light at a wavelength between approximately 390 nanometers and 750 nanometers.3. The phototherapy system of claim 1 , wherein the light source is a plurality of phosphorescent particles.4. The phototherapy system of claim 3 , wherein the aerosolizing element is configured to aerosolize a specific number of phosphorescent particles to achieve a predetermined a particle load to be inhaled by the patient.5. The phototherapy system of claim 3 , wherein the phosphorescent particles define varying diameters such that claim 3 , when inhaled claim 3 , the phosphorescent particles are located throughout a trachea and a bronchial tract of the patient.6. The phototherapy system of claim 3 , wherein the phosphorescent particles are chemically inert and non-toxic to humans.7. The phototherapy system of claim 3 , further comprising an excitation source configured to activate the phosphorescent particles.8. The phototherapy system of claim 7 , wherein the excitation source is at least one of a laser claim 7 , a lamp claim 7 , and one or more light-emitting-diodes.9. The phototherapy system of ...

Therapeutic Gas Delivery Device With Pulsed And Continuous Flow Control

Described are methods and devices for therapeutic or medical gas delivery that utilize at least one proportional control valve and at least one binary control valve. The proportional control valve may be in series with the binary control valve to provide a valve combination capable of pulsing therapeutic gas at different flow rates, depending on the setting of the proportional control valve. Alternatively, the proportional control valve and binary control valve may be in parallel flow paths. 1. A therapeutic gas delivery device comprising:an inlet to connect to a source of therapeutic gas;an outlet to connect to a device that introduces the therapeutic gas to a patient;at least one binary control valve in fluid communication with the inlet and outlet that delivers a constant flow of the therapeutic gas;at least one proportional control valve in fluid communication with the inlet and outlet that delivers a variable flow of the therapeutic gas; anda control system that delivers the therapeutic gas through one or more of the binary control valve and the proportional control valve.2. The therapeutic gas delivery device of claim 1 , wherein the binary control valve and the proportional control valve are in series such that the combination of the binary control valve and the proportional control valve may provide pulses of therapeutic gas at varying flow rates.3. The therapeutic gas delivery device of claim 2 , further comprising a pressure sensor claim 2 , wherein the proportional control valve is upstream of the pressure sensor and the pressure sensor is upstream of the binary control valve.4. The therapeutic gas delivery device of claim 1 , wherein the binary control valve and the proportional control valve are in parallel flow paths.5. The therapeutic gas delivery device of claim 1 , wherein the gas control system delivers the therapeutic gas into a flow of breathing gas through one or more of the binary control valve and the proportional control valve to provide a ...

OXYGEN-CHARGED IMPLANTABLE MEDICAL DEVICES FOR AND METHODS OF LOCAL DELIVERY OF OXYGEN VIA OUTGASSING

Oxygen-charged (or oxygen-rich) implantable medical devices for and methods of local delivery of oxygen via outgassing is disclosed. The presently disclosed oxygen-charged implantable medical devices are, for example, polymeric implants that are functionalized to locally deliver oxygen from the implant surface for prolonged periods of time, thus increasing rates of healing and reducing rates of infection as compared with conventional medical implant devices. 1. An implantable medical device comprising one or more gases dissolved in one or more materials.2. The implantable medical device of claim 1 , comprising one or more gases dissolved in one or more polymeric materials.3. The implantable medical device of claim 2 , wherein the one or more polymeric materials are functionalized.4. The implantable medical device of claim 1 , wherein the material is hyperbarically-charged with one or more gases.5. The implantable medical device of claim 2 , wherein the one or more polymeric materials is selected from the group consisting of polyvinyl alcohol (PVA) claim 2 , polylactic acid (PLA) claim 2 , ethylene vinyl alcohol (EVOH) claim 2 , poly(lactide-co-glycolide) (PLGA) claim 2 , polyglycolide (PGA) claim 2 , nylon claim 2 , polyketone claim 2 , polyether ether ketone (PEEK) claim 2 , polyethylene terephthalate (PET) claim 2 , polyvinylidine chloride (PVDC) claim 2 , polyacrylonitrile (PAN) claim 2 , polyamides (PAs) claim 2 , polyvinyl chloride (PVC) claim 2 , polyvinylidene fluoride (PVDF) claim 2 , polyethylenimine (PEI) claim 2 , polycarbonate (PC) claim 2 , ethylene chlorotrifluoroethylene (ECTFE) claim 2 , polyethylene naphthalene (PEN) claim 2 , polytrimethylene terephthalate (PTT) claim 2 , liquid crystal polymers (e.g. claim 2 , Kevlar) claim 2 , nanocellulose claim 2 , poly(methylmethacrylate (PMMA) claim 2 , polybutylene terephthalate (PBT) claim 2 , poly(p-xylylene) claim 2 , and derivatives thereof.6. The implantable medical device of claim 1 , wherein the one ...

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; and an oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion. 1. An implantable heart treatment device , comprising:a substrate configured for implantation within a body;an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; andan oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart within the body, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion.2. (canceled)3. The implantable heart treatment device of claim 1 , wherein the oxygenator includes a reservoir configured to store the one or more oxygenated molecules.4. The implantable heart ...

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; and an energy-carrier molecule delivery device coupled to the substrate and configured to supply one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body. 1. An implantable heart treatment device , comprising:a substrate configured for implantation within a body;an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; andan energy-carrier molecule delivery device coupled to the substrate and configured to supply one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body.2. The implantable heart treatment device of claim 1 , wherein the one or more non-oxygen cellular energy sources include at least one of adenosine triphosphate (ATP) claim 1 , cyclic adenosine monophosphate (cAMP) claim 1 , adenosine monophosphate (AMP) claim 1 , adenosine diphosphate (ADP) claim 1 , creatine claim 1 , and cyclocreatine.36.-. (canceled)7. The implantable heart treatment device of claim 1 , wherein the energy-carrier molecule delivery device includes a reservoir configured to store the one or more non-oxygen cellular energy sources molecules.8. The implantable heart treatment device of claim 1 , wherein the one or more non-oxygen cellular energy sources are positioned within one or more carrier molecules.911.-. (canceled)12. The implantable heart treatment device of claim 8 , wherein the one or more carrier molecules include at least one targeting agent configured to target cardiac tissue.13. ( ...

SYSTEM FOR THE EXTRACORPOREAL ELIMINATION OF CARBON MONOXIDE

A system for the extracorporeal elimination of carbon monoxide, includes at least one pump and a gas exchange chamber, wherein the at least one pump can be connected to the blood circulatory system of a person by way of a first tube section connectable to a cannula and is connected to a gas exchange chamber via a second tube section, wherein the system is configured to transfer blood, via the first tube section, from the blood circulatory system of the person by way of at least one pump into the gas exchange chamber, and to return the blood from the gas exchange chamber to the blood circulatory system of the person via the same first tube section.

Method and system for monitoring carbon monoxide (co) administration to ex-vivo fluids

The present invention relates to a method for combined administration of carbon monoxide (CO) to an ex-vivo fluid and monitoring of the carbon monoxide administration, said method comprising: (i) generating CO by reacting a CO releasing molecule (CORM) with a release triggering molecule; (ii) administering CO to an ex-vivo fluid by contacting the ex-vivo fluid with the CO generated in step (i) via a gas-permeable membrane; (iii) analyzing carbon monoxide and/or a carbon monoxide marker after administering in step (ii) CO to the ex-vivo fluid by complementary monitoring techniques; (iv) adjusting the CO administration based on the analysis of the carbon monoxide or the carbon monoxide marker carried out in step (iii), if necessary. It furthermore relates to an extracorporeal circuit system for use in the method of the invention.

空气处理系统和方法

空气处理单元可包括：空气入口，该空气入口接收用于处理的输入空气流；以及反应容器，该反应容器被配置成保持水性空气处理液。空气处理单元还可包括与空气入口流动连接的空气分散元件，其中空气分散元件被配置成将输入空气流的至少一部分转换成多个微气泡以引入水性空气处理液中。这样，通过与水性空气处理液反应，减少包含在多个微气泡中的一种或多种目标气体物质的量。该单元可包括空气出口，该空气出口被配置成从反应容器输出处理过的空气。

Air treatment systems and methods

공기 처리 유닛은 처리를 위한 투입 공기 흐름를 수취하기 위한 공기 입구 및 수성 공기 처리 용액을 수용하도록 구성된 반응 용기를 포함할 수 있다. 공기 처리 유닛은 또한 공기 입구와 유체 접속된 공기 분산 요소를 포함할 수 있고, 여기서 공기 분산 요소는 투입 공기 흐름의 적어도 일부를 수성 공기 처리 용액 내에 도입하기 위한 복수의 미세기포로 변환시켜 복수의 미세기포 내에 포함된 하나 이상의 목표 가스 종의 양이 수성 공기 처리 용액과의 반응을 통해 감소되도록 구성된다. 이 유닛은 반응 용기로부터 처리된 공기를 배출하도록 구성된 공기 출구를 포함할 수 있다. The air treatment unit may include an air inlet for receiving an input air stream for treatment and a reaction vessel configured to receive an aqueous air treatment solution. The air treatment unit may also include an air dispersing element in fluid communication with the air inlet, wherein the air dispersing element converts at least a portion of the input air stream into a plurality of microbubbles for introduction into the aqueous air treatment solution to thereby convert a plurality of microbubbles. It is configured such that the amount of one or more target gaseous species contained therein is reduced through reaction with the aqueous air treatment solution. This unit may comprise an air outlet configured to discharge the treated air from the reaction vessel.

Air treatment system and method

空气处理单元可包括：空气入口，该空气入口接收用于处理的输入空气流；以及反应容器，该反应容器被配置成保持水性空气处理液。空气处理单元还可包括与空气入口流动连接的空气分散元件，其中空气分散元件被配置成将输入空气流的至少一部分转换成多个微气泡以引入水性空气处理液中。这样，通过与水性空气处理液反应，减少包含在多个微气泡中的一种或多种目标气体物质的量。该单元可包括空气出口，该空气出口被配置成从反应容器输出处理过的空气。

System and method of administering a pharmaceutical gas to a patient

一种将药用气体释放至患者的方法和系统。该方法和系统不依赖患者的呼吸模式提供给患者已知所需量的药用气体。优选的药用气体为CO和NO，两者都按载气中的浓度提供。气体控制系统决定药用气体释放给患者，从而得到被释放药用气体的已知所需量(如分子、毫克或其他定量单位)。一旦完成多次呼吸期间已知所需量药用气体的释放，系统可终止药用气体的任何进一步释放，或者可激活报警器以警告使用者已释放已知量。该系统也具有报警功能以警告使用者系统可能有故障。

Transportable medical air compressor

一种提供了持续的医用级空气源的方法和设备。大致管状和坚硬的壳体包括：第一端；至少一个孔，其延伸穿过壳体并位于离第一端预定距离处；以及与第一端相对的第二端。阀从壳体的第一端延伸以用于将医用级空气施与患者。医用级空气压缩机提供由阀输出的医用级空气，医用级空气压缩机位于在所述壳体内在所述至少一个孔与所述阀相对的一侧上。气流生成器位于壳体的第二端与医用级空气压缩机之间，气流生成器通过至少一个孔而将空气吸入到壳体中。空气在医用级空气压缩机上方以及周围通过以降低医用级空气压缩机的温度并且到达医用级空气压缩机以生成医用级空气。

Gas delivery device and system

A gas delivery system including a gas delivery device (100), a control module (200) and a gas delivery mechanism is disclosed. An exemplary gas delivery device includes a valve (107) assembly with a valve and circuit including a memory, a processor and a transceiver in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line - of - sight signals (300) to communicate the gas data to the control module. Exemplary gas delivery mechanisms include a ventilator (400) and a breathing circuit (410). Methods of administering gas are also described. The gas date is compared to patient data to verify the correct therapy is being administered. An alarm may indicate when the verification process discovers a discrepancy. Communication between the valve and controller is by way of optical line-of-sight transmission.

Devices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery

본 발명은 인덱싱형 약물 전달 장치(70)에 관한 것으로서, 상기 장치는: - 밸브와 하우징(26)을 포함하는 밸브 조립체(13)를 포함하며, 상기 밸브는 상기 하우징 내에 배열되고, - 상기 하우징에 일체로 구성된 하나 또는 그 이상의 키(34, 38)를 포함하며, 상기 키들은 칼라(12) 위에 있는 상응하는 개구에 대해 상호끼워맞춤 형상을 가지도록 구성되고, - 상기 밸브 조립체와 유체 소통상태에 있는 압축 캐니스터(28)를 포함하며, 상기 캐니스터는 활성 약제 성분과 비활성 캐리어 가스를 함유하고, - 상기 하우징의 일부분 이상과 결합하도록 구성된 용기 및 상기 밸브와 결합하도록 구성된 시트를 포함하는 수용 조립체를 포함하며, - 상기 밸브 조립체와 캐니스터를 축을 따라 선형 작동시켜 상기 밸브와 시트에 결합하도록 구성된 플런저 조립체를 포함하고, 상기 플런저 조립체는 상기 칼라에 고정된 캐리지 및 스프링과 결합하도록 구성된 캠을 가진 레버를 포함하며, 상기 스프링은 상기 캐리지, 밸브 조립체, 캐니스터 및 칼라를 상기 축을 따라 선형 작동시키도록 구성된다. The present invention relates to an indexed drug delivery device (70) comprising: - a valve assembly (13) comprising a valve and a housing (26), the valve being arranged in the housing, - one or more keys (34,38) integrally formed in said housing, said keys being configured to have an inter-fitting shape with respect to a corresponding opening on collar (12) - a compression canister (28) in fluid communication with the valve assembly, the canister containing an active pharmaceutical ingredient and an inert carrier gas, A receiving assembly including a container configured to engage with at least a portion of the housing and a seat configured to engage the valve, A plunger assembly configured to linearly actuate the valve assembly and the canister along an axis to engage the valve and the seat, the plunger assembly including a lever having a cam configured to engage a carriage and a spring secured to the collar, The spring is configured to linearly actuate the carriage, valve assembly, canister and collar along the axis.

Gas transportation facilities and system

本申请描述了一种气体输送系统，包括气体输送设备（100）、控制模块（200）以及气体输送机构。一种示例性的气体输送设备包括阀（107）组件、处理器（122）以及与存储器通信的收发器（120），所述阀组件具有阀和包括存储器（134）的电路。所述存储器可以包括气体数据，例如气体识别信息、气体过期日期以及气体浓度等。所述阀组件的电路上的所述收发器可以发出无线光学视线信号，以将气体数据通信至控制模块。示例性的气体输送机构包括呼吸机（400）以及呼吸回路（410）。本申请还描述了派送气体的方法。

Endoluminal introducer with contamination avoidance

Described herein are introducer devices and methods for using an introducer device to facilitate passing an endoluminal instrument to a target region of a body cavity. An introducer device may include a tubular member having an inner wall that defines a channel configured to receive the endoluminal instrument and a plurality of projections disposed in the channel at perimetrically spaced apart locations around the inner wall, where the projections extend inward and are configured to offset the endoluminal instrument from the inner wall, thereby creating a space between the endoluminal instrument and the inner wall. A method for using an introducer device may include passing the endoluminal instrument to a first instrument insertion depth within the introducer device, advancing the introducer device in the body cavity, and advancing the endoluminal instrument to a second instrument insertion depth within the introducer device.

Indexing medicine accommodation apparatus component and indexing drug delivery system for medicine delivery adjusting means

一种分度药物递送装置(70)包括：阀组件(13)，其包括壳体(26)和阀，所述阀布置在所述壳体内；与所述壳体一体形成的一个或多个键槽(34，38)，所述键槽与轴环(12)上对应的开口互补；增压筒(28)，其与所述阀组件流体连通，所述筒收容活性药物成分和非活性载气；接受组件，其包括适于啮合壳体的至少部分的受器以及适于啮合阀的阀座；以及柱塞组件，其适于沿着轴线线性地致动阀组件和筒并且使阀和阀座啮合，所述柱塞组件包括与轴环固定的滑架以及具有适于啮合弹簧的凸轮的杠杆，所述弹簧适于沿着所述轴线线性地致动所述滑架、阀组件、筒和轴环。

Therapeutic vaporizer and components thereof

A therapeutic vaporizer inhalation bag attachment system with an integrated valve is disclosed. The attachment system includes a body having a lumen extending between the two openings of the body, a bag coupling, and a valve positioned within the lumen. A method of using the inhalation bag attachment system is also disclosed.

DEVICE FOR CONNECTION OF INDEXED VALVE AND PRESSURE CONTAINER ASSEMBLY WITH REQUIREMENTS AND FOR LINEAR ACTIVATION WITH PISTON COLLECTION IN FLUID CONNECTION WITH DEVICE FOR REGULATION OF MEDICINE DELIVERY

Transportable medical air compressor

A method and apparatus (10) provides a continuous source of medical grade air. A substantially tubular and rigid housing (12) includes a first end (16), at least one aperture (20) extending through the housing and positioned a predetermined distance from the first end; and a second end (24), opposite the first end. A valve (18) extends from the first end of the housing for dispensing medical grade air to a patient. A medical grade air compressor (11) provides medical grade air for output by the valve, the medical grade air compressor being positioned within the housing on a side of the at least one aperture opposite the valve. An air flow generator (22) is positioned between the second end of the housing and the medical grade air compressor, the air flow generator draws air into the housing through the at least one aperture. The air passes over and around the medical grade air compressor to reduce a temperature of the medical grade air compressor and to the medical grade air compressor for generating medical grade air.

Method and apparatus for the administration of co

Customizable mandatory/spontaneous closed loop mode selection

A multimode ventilator (100) is disclosed that provides physicians and clinicians the ability to select multiple modes of operation for the ventilator (100). Embodiments of the present disclosure provide users with the ability to select from multiple modes of ventilator operations. The users may also set transition conditions and monitoring thresholds that determine when the multimode ventilator transitions between the selected modes of operations. Multiple user interfaces (120) are also disclosed that allow the user to interact with the multimode ventilator (100) in order to select particular modes of operation, transition conditions, and monitoring thresholds.

Transversely-activated valve for a therapeutic vaporizer bag attachment system

A therapeutic vaporizer inhalation bag attachment system with an integrated valve includes a body having a lumen extending between the two openings of the body, a bag coupling, and a valve positioned within the lumen. A first end of the body may include a mouthpiece and the second end of the body may include bag coupling to attach an inhalation bag. The body may include a plurality of cooling ribs extending in parallel with the lumen along an outer surface of a sidewall of the body. The valve may be a duck-bill valve configured to move between a first position which allows flow of vapor through the lumen in a first direction extending from the first opening to the second opening, and a second position which prevents substantial flow of vapor through the lumen in a second direction from the second opening to the first opening, the valve having two flaps extending within the lumen inwardly from an inner sidewall of the body

System and method of administering a pharmaceutical gas to a patient

A method and system for delivering a pharmaceutical gas to a patient. The method and system provide a known desired quantity of the pharmaceutical gas to the patient independent of the respiratory pattern of the patient. The preferred pharmaceutical gases are CO and NO, both of which are provided as a concentration in a carrier gas. The gas control system determines the delivery of the pharmaceutical gas to the patient to result in the known desired quantity (e.g. in molecules, milligrams or other quantified units) of the pharmaceutical gas being delivered. Upon completion of that known desired quantity of pharmaceutical gas over a plurality of breaths, the system can either terminate any further delivery of the pharmaceutical gas or can activate an alarm to alert the user that the known quantity has been delivered. The system also has alarm functions to alert the user of possible malfunctions of the system.

Respiratory mask and ventilator assembly

The invention relates to a respiratory mask (1) for ventilating a patient, comprising a contact surface (5) which is circumferential in an annular manner and which can be placed on the face (14) of the patient; a curved hood (12), on the edge of which the contact surface (5) runs; and an inlet opening (6) for the respiratory air to be supplied to the patient. According to the invention, the hood (12) is designed to be flat in the vicinity of the face such that the respiratory mask (1) encloses as little volume as possible between the face (14) of the patient and the hood (12), and the respiratory mask (1) has an outlet opening (9) for the respiratory air exhaled by the patient. The invention further relates to a ventilator assembly comprising a ventilator device (11) which has a pump (10) for pumping a respiratory gas mixture, referred to as supply air; a supply air line which conducts the supply air from the ventilator device (11) to the inlet opening (6) of an aforementioned respiratory mask (1); and a discharge air line which conducts the respiratory air exhaled by the patient, referred to as discharge air, to the ventilator device (11).

Modular extracorporeal systems and methods for treating blood-borne diseases

Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.

system and method of administering a pharmaceutical gas to a patient

SISTEMA E MéTODO DE ADMINISTRAçãO DE UM GáS FARMACêUTICO A UM PACIENTE. A presente invenção refere-se a um método e sistema para o envio de um gás farmacêutico a um paciente. O método e sistema propor- cionam uma quantidade desejada de um gás farmacêutico a um paciente independente do padrão respiratório do paciente. Os gases farmacêuticos preferidos são CO e NO, ambos os quais são proporcionados como uma concentração em um gás veículo. O sistema de controle de gás determina o envio de um gás farmacêutico ao paciente para resultar na quantidade desejada conhecida (por exemplo, em moléculas, miligramas ou outras unidades quantificadas) do gás farmacêutico sendo enviado. Com a conclusão da re- ferida quantidade desejada conhecida de gás farmacêutico em uma plurali- dade de respirações, o sistema pode ou terminar qualquer envio adicional de gás farmacêutico ou pode ativar um alarme para alertar ao usuário de que a quantidade conhecida foi enviada. O sistema é também dotado de funções de alarme para alertar o usuário de possíveis maus funcionamentos do sistema. SYSTEM AND METHOD OF ADMINISTRATION OF A PHARMACEUTICAL GAS TO A PATIENT. The present invention relates to a method and system for sending a pharmaceutical gas to a patient. The method and system provide a desired amount of a pharmaceutical gas to a patient regardless of the patient's breathing pattern. Preferred pharmaceutical gases are CO and NO, both of which are provided as a concentration in a carrier gas. The gas control system determines the delivery of a pharmaceutical gas to the patient to result in the desired desired amount (e.g., molecules, milligrams or other quantified units) of the pharmaceutical gas being delivered. Upon completion of said desired known amount of pharmaceutical gas in a plurality of breaths, the system may either terminate any additional delivery of pharmaceutical gas or may activate an alarm to alert the user that the known amount has been sent. The system is also equipped ...

Adapter, apparatus and method for exhaled breath measurements

An adapter ( 1 ) for an exhaled breath measurement apparatus ( 2 ), comprising a first inlet ( 3 ) for tidal breathing, a second inlet ( 4 ) for air free from one or more component to be measured, through which and a first one-way valve ( 5 ) air flows when a test person inhales through the adapter ( 1 ) at the first inlet ( 3 ), and an outlet ( 6 ) for exhaled breath having a second one-way valve ( 7 ). A sample tubing ( 11 ) is positioned next to the first inlet ( 3 ) for tidal breathing for a continuous sample from the exhaled breath immediately inside the adapter ( 1 ), upstream the second one-way valve ( 7 ) at the outlet ( 6 ) for exhaled breath. An exhaled breath measurement apparatus ( 2 ) with such adapter ( 1 ). A method for measuring exhaled breath during tidal breathing by sampling continuously in an adapter ( 1 ) at a first inlet ( 3 ) into which a test person breathes, the sampling taking place upstream of an outlet ( 6 ) for exhaled breath.

Method and apparatus for assigning CO

Oppfinnelsen angår en fremgangsmåte og en innretning for tildeling av karbonmonoksid (eO) til en pasient. Den tillater sikker og effektiv bruk av karbonmonoksid som et medikament.

System and method of administering a pharmaceutical gas to a patient

一种将药用气体释放至患者的方法和系统。该方法和系统不依赖患者的呼吸模式提供给患者已知所需量的药用气体。优选的药用气体为CO和NO，两者都按载气中的浓度提供。气体控制系统决定药用气体释放给患者，从而得到被释放药用气体的已知所需量(如分子、毫克或其他定量单位)。一旦完成多次呼吸期间已知所需量药用气体的释放，系统可终止药用气体的任何进一步释放，或者可激活报警器以警告使用者已释放已知量。该系统也具有报警功能以警告使用者系统可能有故障。

Nasal cavity washing catheter

A nasal cavity washing catheter (6) is manufactured from silica gel or other flexible materials and can be independently operated by a patient. The catheter (6) comprises a sealed end (611) and an open end (612) opposite to the sealed end (611). The catheter (6) is provided with multiple side holes (613) at positions, close to the sealed end (611), and when functioning together with a connector (62) and a syringe (7), the catheter (6) sprays multiple strong slender water columns to the nasal cavity and the nasopharynx, so as to remove mucus and nasal discharge (MC). The catheter (6) can internally comprise at least one probe (8) to improve the operability. At an injection speed 10 cc/s, the total area of the side holes (613) can determine the height of sprayed vertical water columns, and distinguish the catheter (6) into: 1. a low-pressure catheter (6) capable of generating water columns of 30-45 cm, the total area of the side holes (613) of the low-pressure catheter (6) ranging from 3.367 mm 2 to 4.123 mm 2 ; 2. a medium-pressure catheter (6) capable of generating water columns of 45-90 cm, the total area of the side holes (613) of the medium-pressure catheter (6) ranging from 2.381 mm 2 to 3.367 mm 2 ; and 3. a high-pressure catheter (6) capable of generating water columns of more than 90 cm, the total area of the side holes (613) of the high-pressure catheter (6) being smaller than 2.381 mm 2 .

Method for pulsatile delivery of a gaseous drug

Described are methods for providing a pulsed dose of a gaseous drug over a portion of total inspiratory time, where the dose of the gaseous drug is delivered at a concentration of nL of gaseous drug per mL tidal volume.

Devices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery

System of administration of a therapeutic gas to a patient

Un sistema de administración de óxido nítrico (22) que comprende: una entrada (24) para conectarse a una fuente de gas terapéutico( 20) que comprende óxido nítrico; una salida para conectarse a un dispositivo (18) que introduce el gas terapéutico en un paciente (41); una primera válvula de control de flujo (30) en comunicación fluida con la entrada y la salida, en donde la primera válvula de control de flujo (30) administra el gas terapéutico a un primer caudal; una segunda válvula de control de flujo (28) en comunicación fluida con la entrada y la salida y en paralelo a la primera válvula de control de flujo (30), en donde la segunda válvula de control de flujo (28) administra el gas terapéutico a un segundo caudal que es más elevado que el primer caudal; y un sistema de control de gas que administra una dosis del gas terapéutico al flujo de gas inspiratorio del paciente a través de una o más de la primera válvula de control de flujo y la segunda válvula de control de flujo. caracterizado por que la primera válvula de control de flujo (30) proporciona un flujo de gas terapéutico de aproximadamente 1 l/min y en donde la segunda válvula de control de flujo (28) proporciona un flujo de gas terapéutico de aproximadamente 6 l/min. A nitric oxide delivery system (22) comprising: an inlet (24) for connecting to a therapeutic gas source (20) comprising nitric oxide; an outlet to connect to a device (18) that introduces the therapeutic gas into a patient (41); a first flow control valve (30) in fluid communication with the inlet and outlet, wherein the first flow control valve (30) administers the therapeutic gas at a first flow rate; a second flow control valve (28) in fluid communication with the inlet and outlet and in parallel to the first flow control valve (30), wherein the second flow control valve (28) administers the therapeutic gas at a second flow rate that is higher than the first flow rate; and a gas control system that administers a dose of therapeutic gas to ...

Artificial respirator

Method and apparatus for the administration of CO

The present invention relates to a method and apparatus for the administration of carbon monoxide (CO) to a patient. It allows the safe and effective use of carbon monoxide as a medicament.

System of administering a pharmaceutical gas to a patient

Patent BRPI0924534A2

METHOD AND APPARATUS FOR INTRODUCTION OF CARBON MONOXIDE TO THE ORGANISM

В заявке описаны способ и аппарат для введения в организм пациента моноксида углерода. Предлагаемые в изобретении способ и аппарат позволяют безопасно и эффективно использовать моноксид углерода в качестве лекарственного средства.Международная заявка была опубликована вместе с отчетом о международном поиске.

Smoking apparatus and method

Apparatus consistent with the present disclosure may be a pipe that includes heat transfer materials that have a thermal conductivity of greater than 50 Watts per meter Kelvin. Heat transfer materials may include one or more solid heat sinks (that are rigidly connected to each other or to a portion of the pipe), Peltier devices, or loose fill of a desired size or shape. Fill included in the pipe may also absorb particulate matter or volatile organic compounds. As a user burns or vaporizes materials at one end of the pipe and sucks heated smoke or vapor into the pipe, that user may inhale cool and clean smoke or vapor. Methods and apparatus consistent with the present disclosure may allow a controller at the pipe to send sensor or consumption data to other electronic devices when a number of milligrams of a substance inhaled by a patient are monitored.

Phototherapy systems and methods for preventing or treating carbon monoxide poisoning

提供了用于治疗或预防一氧化碳中毒的系统和方法。具体而言，提供了用于光疗治疗或预防系统的系统和方法，其将光辐射传递到患者的身体以从血红蛋白光解离一氧化碳。

System of administering a pharmaceutical gas to a patient

Gas delivery device and system

A gas delivery system including a gas delivery device (100), a control module (200) and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve (107) assembly with a valve and circuit including a memory (134), a processor (122) and a transceiver (120) in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver on the circuit of the valve assembly may send wireless optical line - of - sight signals to communicate the gas data to a control module. Exemplary gas delivery mechanisms include a ventilator (400) and a breathing circuit (410). Methods of administering gas are also described.

Method and apparatus for the administration of co

The present invention relates to a method and apparatus for the administration of carbon monoxide (CO) to a patient. It allows the safe and effective use of carbon monoxide as a medicament.

Air treatment system and method

Gas-evolving compositions and container and delivery systems

A gas-evolving composition delivery system is disclosed, which comprises a pressurized container having a dispenser, and a liquid gas-evolving composition, such as an acidified nitrite solution, within the pressurized container, wherein the pressurized container has an internal pressure sufficient to minimize gas production from the gas-evolving composition while within the container. Also disclosed is a method of stabilizing an acidified nitrite solution comprising loading the solution into a container and sealing the container to be airtight.

System for extracorporeal elimination of carbon monoxide

Die Erfindung betrifft ein System zur extrakorporalen Elimination von Kohlenmonoxid, umfassend zumindest eine Pumpe (5) und eine Gasaustauschkammer (6), wobei wenigstens eine Pumpe (5) durch einen mit einer Kanüle (2) verbindbaren ersten Schlauchabschnitt (3) mit dem Blutkreislauf einer Person (1) verbindbar ist und über einen zweiten Schlauchabschnitt (4) mit einer Gasaustauschkammer (6) verbunden ist, wobei das System dazu eingerichtet ist Blut mittels zumindest einer Pumpe (5) über den ersten Schlauchabschnitt (3) aus dem Blutkreislauf der Person (1) in die Gasaustauschkammer (6) abzuführen und aus der Gasaustauschkammer (6) über denselben ersten Schlauchabschnitt (3) in den Blutkreislauf der Person (1) zurückzuführen. The invention relates to a system for the extracorporeal elimination of carbon monoxide, comprising at least one pump (5) and a gas exchange chamber (6), wherein at least one pump (5) by a with a cannula (2) connectable first tube section (3) with the blood circulation of a Person (1) is connectable and connected via a second tube section (4) with a gas exchange chamber (6), wherein the system is adapted to blood by means of at least one pump (5) via the first tube section (3) from the blood circulation of the person ( 1) into the gas exchange chamber (6) and return from the gas exchange chamber (6) via the same first tube section (3) in the bloodstream of the person (1).

Devices for engaging indexed valve and pressurized canister assembly with collar

Devices and methods for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery

An indexed drug delivery device ( 70 ) comprising a valve assembly ( 13 ) comprising a housing ( 26 ) and a valve, the valve disposed within the housing, one or more keys ( 34,38 ) integral to the housing, the keys complementary to corresponding openings on a collar ( 12 ), a pressurized canister ( 28 ) in fluid communication with the valve assembly, the canister containing an active pharmaceutical ingredient and an inactive carrier gas, a receiving assembly comprising a receptacle adapted to engage at least a portion of the housing, a seat adapted to engage the valve, and, a plunger assembly adapted to linearly actuate the valve assembly and canister along an axis and to engage the valve and seat, the plunger assembly comprising a carriage fixed to the collar, and, a lever having a cam adapted to engage a spring, the spring adapted to linearly actuate the carriage, valve assembly, canister and collar along the axis.

gas distribution device and system

dispositivo e sistema de entrega de gás um sistema de entrega de gás incluindo um dispositivo de entrega de gás (100), um módulo de controle (200) e um mecanismo de entrega de gás é descrito. um dispositivo de entrega de gás exemplar inclui um conjunto de válvula (107) com uma válvula e circuito incluindo uma memória (134), um processador (122) e um transceptor (120) em comunicação com a memória. a memória pode incluir dados de gás tais como a identificação de gás, expiração de gás e concentração de gás. o transceptor no circuito do conjunto de válvula pode enviar sinais de linha de vista ópticos sem fio para comunicar os dados de gás para um módulo de controle. exemplos de mecanismos de entrega de gás incluem um ventilador (400) e um circuito de respiração (410). os métodos de administração de gás são também descritos. gas delivery device and system a gas delivery system including a gas delivery device (100), a control module (200) and a gas delivery mechanism is described. An exemplary gas delivery device includes a valve assembly (107) with a valve and circuit including a memory (134), a processor (122) and a transceiver (120) in communication with the memory. The memory may include gas data such as gas identification, gas expiration and gas concentration. The transceiver in the valve assembly circuit can send wireless optical line of sight signals to communicate gas data to a control module. Examples of gas delivery mechanisms include a ventilator (400) and a breathing circuit (410). Gas delivery methods are also described.

Breathing control using high flow respiration assistance

Device for engaging indexed valve and pressurized canister assembly with collar and for linear actuation by plunger assembly into fluid communication with device for regulating drug delivery

CO administration method and apparatus

本発明は、患者に一酸化炭素（ＣＯ）を投与するための方法及び装置に関する。本発明は、薬剤としての一酸化炭素の安全で、かつ、効果的な使用を可能にする。

Therapeutic gas delivery device with pulsed and continuous flow control

Described is a device (100) for therapeutic or medical gas delivery that utilizes at least one binary control valve (109) and a variable pressure controller (107, 115) located upstream and in fluid communication with the binary control valve to vary the pressure upstream of the binary control valve. A control system being in communication with the variable pressure regulator, delivers the therapeutic gas through the binary control valve.

System for supporting gas exchange in patients

Die Erfindung betrifft ein System zur Unterstützung des Gasaustauschs bei Patienten (2) in Ergänzung oder statt eines Beatmungsgeräts. Das System (1) weist eine Fördereinheit (15) für Atemgas, einen Gasanalyse-Sensor (19) und eine Steuerung (37) auf, Um den Bedienungs- und Kontrollaufwand für den Therapeuten zu verringern, schlägt die Erfindung vor, dass eine einstellbare Eliminationsrate des Systems (1) für CO 2 im Ausatemgas durch automatische Regelung der Fördereinheit (15) mittels der Steuerung (37) in Abhängigkeit von Messwerten des Gasanalyse-Sensors (19) konstant gehalten wird. The invention relates to a system for assisting the gas exchange in patients (2) in addition to or instead of a ventilator. The system (1) comprises a breathing gas delivery unit (15), a gas analysis sensor (19) and a controller (37). In order to reduce the operator's effort to operate and control, the invention proposes that an adjustable elimination rate of the system (1) for CO 2 in the exhaled gas is kept constant by automatic control of the delivery unit (15) by means of the control (37) as a function of measured values of the gas analysis sensor (19).