УСТРОЙСТВО И СПОСОБ ДЛЯ ЛЕЧЕНИЯ РАН

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DEVICE FOR THE SUPPLY OF A CERTAIN VOLUME OF AUXILIARY ARTIFICIALLY RESPIRATING GAS PRO TIME UNIT FOR A IN VIVO BEATMUNGSYSTEM.

GERÄT ZUR BEHANDLUNG DES MENSCHLICHEN KÖRPERS

Bei einem Gerät zur Behandlung des menschlichen Körpers mittels elektrischer und/oder magnetischer Impulse sowie akustischer Impulse werden diese dem Körper mittels Elektroden, Magnetfeldsonden, Kopfhörer und/oder Körperschallübertragungseinrichtungen aufgrund von durch das Gerät erzeugten elektrischen Ausgangssignalen zugeführt. Dabei ist eine von Hand über Eingabeeinrichtungen (30,38,50,52,58,62) oder mittels einsteckbarer Programmsteuerkarten programmierbare Zentraleinheit (CPU) (90) vorgesehen, die einen Körpersignaleingang (70) für von am Körper anzubringenden Elektroden oder Magnetfeldsonden zugeführte Körpersignale, zwei Farbsignalausgänge (78,80) und zwei Tonsignalausgänge (86) sowie zwei Farbsignalerzeuger und zwei Tonsignalerzeuger aufweist, die durch die Körpersignale steuerbar und mit den jeweiligen Ausgängen verbunden sind.

PRINTING SYSTEM FOR BREATHING WAYS

RESPIRATING GAS SUPPLY METHOD AND APPARATUS THEREFOR

Method of treating depression, mood disorders and anxiety disorders using neuromodulation

SEALED TWO-WAY MAGNETIC MANIFOLD

An irrigated medical device, including an inlet tube configured to receive an irrigation fluid from a pressurized fluid source, at least first and second outlet tubes configured to deliver the irrigation fluid to respective outlets of the device, a manifold containing a chamber coupled between the inlet tube and at least the first and second outlet tubes, and a ball including a magnetic material contained inside the chamber. The irrigated medical device also includes a magnetic field generator disposed outside the chamber and configured to generate a variable magnetic field within the chamber so as to move the ball between at least a first position in which the first outlet tube is blocked, a second position in which the second outlet tube is blocked, and a third position, in which neither of the outlet tubes is blocked.

Device and method for removing protein-bound toxins from the blood of patients using a high-frequency, electromagnetic field and an electrostatic direct current field

The present invention relates to a dialysis device comprising a dialysis circuit (2), a blood circuit (5) and a dialyzer (4), characterized in that the dialysis device has means (7) for generating a high-frequency electromagnetic field and means (9) for generating an electrostatic direct current field, wherein both means (7, 9) are arranged in such a way that blood to be treated can be exposed to the high-frequency electromagnetic field and the electrostatic direct current field when passing through the dialyzer.

HIGH FREQUENCY ELECTRONIC DEPILATORY DEVICE

INTRACARDIAC PUMP

An intra-cardiac device component (ICDC) is inserted into one to four chambers of the heart. The ICDC in the right atrium and left atrium expands while the tricuspid and mitral valves are open during the first-time epoch. The expansion in the right atrium and left atrium pushes blood from these atriums into their respective ventricles. The ICDC in the right ventricle and left ventricle contracts at this time epoch and the pulmonary and aortic valves are closed. In the succeeding time epoch, the ICDC in the right atrium and left atrium contracts while the tricuspid and mitral valves are closed, and the right atrium and left atrium are filling with blood. The ICDC in the right ventricle and left ventricle expand in this time epoch while the pulmonary and aortic valves are open. This sequence increases blood flow into the pulmonary artery and aorta and helps to remedy the decreased ability to pump blood in heart failure patients.

HAEMODIAFILTRATION METHOD

The invention relates to a device for haemodiafiltration comprising an extracorporeal circulation (10) for receiving blood to be cleaned and comprising a haemodialyser and/or haemofilter (20) which is connected to the blood circulation (10), said blood circulation (10) having at least one respective supply line (12, 14) located upstream and downstream of the haemodialyser and/or haemofilter (20), for supplying a substitution fluid. The invention is characterised in that the device also comprises measuring devices for recording the transmembrane pressure and/or haematocrit (HKT) and/or blood density, the measuring devices being connected to a control unit (100) for controlling one or more of the transmembrane pressure, and/or haematocrit (HKT) and/or blood density and said control unit (100) being constructed in such a way that the control is carried out (13, 15) with the aid of at least one of the infusion speeds (Qspre, Qspost) of the substitution fluid. The invention is also characterised ...

MUSCLE CONTROL AND MONITORING SYSTEM

... 2120617 9308874 PCTABS00021 Apparatus and method for monitoring the performance of skeletal muscle used in a skeletal muscle powered cardiac assist system. The longest term monitoring is performed by an oxygen sensor which determines the adequacy of circulatory support to the skeletal muscle. An adequately supported skeletal muscle can offer the desired cardiac assistance chronically. Insufficient support indicates that the skeletal muscle will easily fatigue if adequate vascularization is not achieved. If the circulatory support is chronically insufficient, the risk of ischemia becomes high and additional surgical intervention may be required. A somewhat shorter term concern is the adequacy of the conditioning needed to render a fast twitch skeletal muscle useful in assisting the slow twitch myocardium. A pressure transducer is used to measure conditioning sufficiency. A third type of monitoring provides an indication of changes in cardiac requirements utilizing an activity sensor. This ...

INSPIRATORY AIRWAY PRESSURE SYSTEM

An apparatus and method for facilitating the respiration of a patient are disclosed which are particularly useful in treating mixed and obstructive sl eep apnea and certain cardiovascular conditions, among others, by increasing nas al air pressure delivered to the patient's respiratory passages just prior to i nhalation and by subsequently decreasing the pressure to ease exhalation effort. The preferred apparatus includes a patient-coupled gas delivery device for press urizing the patient's nasal passages at a controllable pressure, and a controller co upled with the delivery device having a pressure transducer for monitoring the nas al pressure and a microcontroller for selectively controlling the nasal pressur e. In operation, the controller determines a point in the patient breathing cycle just prior to inhalation and initiates an increase in nasal pressure at that point in o rder to stimulate normal inhalation, and subsequently lowers the nasal pressure to e ase exhalation efforts.

Hybrid system for the treatment of pain uses drug administration and electrostimulation and comprises an electrocatheter with holes in its distal end for drug infusion

Pain-treatment system comprises an electrocatheter (8) terminating with a connector, a drug flow regulator (21), cabling (3) for the hydraulic and electrical connection between the electrocatheter and the apparatus used for drug administration and electrical stimulation, a drug-administration pump device (1), an electronic circuit with battery for generating a stimulating electrical signal and a ground electrode (7). The distal end (10) of the electrocatheter comprises holes for infusion of the drug.

HEMOFILTRATION METHOD

CANCER IMMUNOTHERAPY BY MEANS OF RADIO-FREQUENCY ELECTRIC BREAKDOWN MEMBRANE (RF IS-AND-EMB)

DEVICE FOR REMOVING PROTEIN-BOUND TOXINS FROM THE BLOOD OF PATIENTS USING A HIGH-FREQUENCY ELECTROMAGNETIC FIELD AND AN ELECTROSTATIC DIRECT CURRENT FIELD

Apparatus and method for treatment of the skin

Le procédé de traitement de la peau (2), notamment une épilation longue durée, consiste à induire un courant électromagnétique de haute fréquence à travers la peau à l'aide d'un gel conducteur (3) chargé de produit traitant et appliqué sur la peau à l'endroit voulu, le courant électromagnétique amenant ce produit à pénétrer les pores de la peau. L'appareil comprend un organe maniable de contact (1) avec la peau (2) ayant un corps non-conducteur (10, 12) pourvu d'une surface d'appui oblongue (17) comportant une rangée de points conducteurs d'émission électromagnétique distincts (15). Ces points (15) débouchent par des orifices dans cette surface, de préférence en retrait par rapport à celle-ci, de manière à contacter du gel conducteur chargé (3) appliqué sur la peau. Un circuit électrique (26) fournit aux points d'émission (15) du courant à haute fréquence émetteur pur émis par lesdits points à travers le gel (3).

Disposable anti-pruritus device mounted on haemodialyser generator

Presentación de antígeno de cáncer mejorado a células que presentan antígeno por la descomposición eléctrica de membrana por radiofrecuencia (rf-emb) como un mecanismo adyuvante para la inmunoterapia.

DEVICE FOR REMOVING PROTEIN-BOUND TOXINS FROM BLOOD PLASMA

The invention relates to a device for the extracorporeal removal of protein-bound toxins from blood plasma comprising: a first (10), second (12), third (24) and fourth (27) line device; a dialyser or haemofilter (18) and/or an adsorber (19) located between the first (10) and the second (12) line device; a means for generating a field (14), said means at least partially surrounding the first line device (10) and/or the dialyser or haemofilter (18) and/or the adsorber (19); a controllable fluid transport device (16) located in the first (10) and/or second (12) line device and at least one controllable body fluid transport device (16) located in the third (24) and/or fourth (27) line device; a filter (20), the permeate side of the filter (20) being connected to the first (10) and the second (12) line device, the inlet (22) on the dialysis side of the filter (20) being connected to the third line device (24) which can be connected to a patient (P), and the outlet (26) on said dialysis side ...

REGIONAL THERAPIES FOR TREATMENT OF PAIN

Enhanced therapies for treating pain are described. The therapies include subcutaneous stimulation of tissue in proximity to a source of pain at low frequencies (less than about 20 Hz) and high frequencies (greater than about 50 Hz). The therapies further include administering a pain treating agent at a predetermined time relative to application of the high or low frequency stimulation. Delivery of the pain treating agent via an implantable infusion system is described. Coordination of output of an infusion device and a pulse generator to provide coordinated therapy is also discussed.

APPARATUS FOR THE EXTRACORPOREAL REMOVAL OF PROTEIN-BOUND TOXINS

The present invention relates to an apparatus for the extracorporeal removal of protein-bound toxins from blood comprising at least one blood purification apparatus, in particular at least one dialysis machine, hemofilter or adsorber, as well as at least one means for generating a field in the blood purification apparatus and/or in an element in flow communication with the blood purification apparatus, in particular in a line section connected to the blood purification apparatus, wherein the means comprises at least two strip conductors which are arranged on at least two preferably oppositely disposed sides of the blood purification apparatus or of the element such that the field is preferably predominantly generated within the blood purification apparatus or preferably predominantly within the element.

System for reducing local discomfort

A device for targeted delivery of a substance to an airway may include a conduit and at least two applicators. The conduit may include a proximal end and a bifurcated distal portion having two distal ends. Each applicator may be coupled with one of the distal ends of the conduit and may be configured to direct the substance out of the applicator toward one of two sides of an airway. A method for targeted delivery of a substance to an airway may involve advancing a substance delivery device into the airway, contacting two sides of the airway with at least two applicators of the substance delivery device, such that each applicator contacts the airway near a glossopharyngeal nerve and/or a superior laryngeal nerve on each of the two sides of the airway, and delivering the substance through the applicators to contact the airway along the two sides.

Drug delivery to ilioinguinal nerve to alleviate chronic pelvic pain

The disclosure describes a method and system for delivering a drug to an ilioinguinal nerve of a patient. The system includes drug delivery devices that deliver one or more drugs for alleviation of pelvic pain. The system may deliver drug therapy for pelvic pain in men or women. Drug therapy may be delivered at various locations along a single or both ilioinguinal nerves of a patient via a fluid transfer device. In some embodiments, electrical stimulation may be applied in combination with drug therapy to one or both ilioinguinal nerves of a patient.

Physiologically responsive VAD

A ventricular assist device incorporating a rotary pump such as a rotary impeller pump implantable in fluid communication with a ventricle and an artery to assist blood flow from the ventricle to the artery. The device includes a pump drive circuit supplying power to the pump, one or more sensors for sensing one or more electrophysiological signals such as electrogram signals in and a signal processing circuit connected to the sensors and to the pump drive circuit. The signal processing circuit is operative to detect the sensor signals and control power supplied to the pump from the pump drive circuit so that the pump runs in a pulsatile mode, with a varying speed synchronized with the cardiac cycle. When an arrhythmia is detected, the pump drive circuit may also run the pump in an atrial arrhythmia mode or a ventricular arrhythmia mode different from the normal pulsatile mode.

Device and a method for providing resuscitation or suspended state in cardiac arrest

Disclosed is a device for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a patient. The device includes an electrically controllable redistribution component attachable to the patient to provide redistribution of the cardiac output to increase supply to the brain and heart. The redistribution component, following a predefined reaction pattern based on an electrical signal, and computer means configured to: receive a patient data which identifies physiological and/or anatomical characteristics of the patent; and provide the electrical signal for the redistribution component based on the patient data or a standard response. The device may provide mechanisms to protect the aorta and the remaining anatomy of the patient from inadvertent damage caused by the disclosed device in any usage scenario of either correct intended usage or unintended usage. Also disclosed is a method for providing resuscitation or suspended ...

ATRIAL DEFIBRILLATION USING AN IMPLANTABLE DEFIBRILLATION SYSTEM

СИСТЕМЫ И СПОСОБЫ ПОЛУЧЕНИЯ ОКСИДА АЗОТА В АМБУЛАТОРНЫХ УСЛОВИЯХ

УСТРОЙСТВО И СПОСОБ ДЛЯ ПРОВЕДЕНИЯ РЕАНИМАЦИИ ИЛИ ОБЕСПЕЧЕНИЯ СОСТОЯНИЯ ВРЕМЕННОЙ ПРИОСТАНОВКИ ЖИЗНЕДЕЯТЕЛЬНОСТИ ПРИ ОСТАНОВКЕ СЕРДЦА, ЗАКУПОРИВАЮЩЕЕ УСТРОЙСТВО И СВЯЗАННЫЙ С НИМ СПОСОБ

Устройство для электропорации

Improvement in and relating to catheter needles

A catheter needle (2) is inserted into muscle tissue (20) of a patient. A needle tip aperture (28) includes a deflection member (30) orientated such that a catheter (12) emerging from the aperture (28) is deflected at an acute angle from the longitudinal axis of the needle body.

DEVICE FOR DELIVERING PHARMACEUTICALS TO THE INTERIOR EAR

PRINTING SYSTEM FOR BREATHING WAYS

Implantable heart-assist device

MUSCLE CONTROL AND MONITORING SYSTEM

Atrial defibrillation using an implantable defibrillation system

Apparatus and method for improved assisted ventilation

Devices and methods for allowing for improved assisted ventilation of a patient. The methods and devices provide a number of benefits over conventional approaches for assisted ventilation. For example, the methods and devices described herein permit blind insertion of a device that can allow ventilation regardless of whether the device is positioned within a trachea or an esophagus. NtN ...

SYSTEM AND METHOD FOR DETECTION OF A STIMULATED MOTION REACTION

A stimulation electrode assembly configured to be positioned relative to a patient for an operative procedure is disclosed. An evoked stimulation response may be sensed by a sensor near a portion of a subject. The evoked response may be sensed by an electrode and determined with a monitoring system. The evoked response may additionally and/or alternatively be sensed with a motion sensor. A position sensor may be provided to measure or determine whether the sensor has moved during a procedure.

ELECTROPORATION SYSTEMS, METHODS, AND APPARATUS

Provided herein are systems, methods, and apparatus for electroporation, which may include an applicator; an endoscope, trocar or the like; a generator; and a drug delivery device. The applicator may include a control portion, an insertion tube connected to the control portion, an actuator engaged with the control portion, and a plurality of electrodes comprising a first electrode having a first tip and a second electrode having a second tip. The plurality electrodes may be configured to move between a retracted position and a deployed position in response to actuation by the actuator. A distance between the first tip of the first electrode and the second tip of the second electrode may be greater in the deployed position than in the retracted position. Various treatment methods are also provided.

SYSTEMS AND METHODS FOR AMBULATORY GENERATION OF NITRIC OXIDE

The present disclosure relates to systems and methods for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula.

APPARATUS AND METHOD FOR IMPROVED ASSISTED VENTILATION

Devices and methods for allowing for improved assisted ventilation of a patient. The methods and devices provide a number of benefits over conventional approaches for assisted ventilation. For example, the methods and devices described herein permit blind insertion of a device that can allow ventilation regardless of whether the device is positioned within a trachea or an esophagus.

SYSTEM AND METHOD FOR WOUND HEALING

A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between, the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode.

DEVICE AND METHOD FOR REMOVING PROTEIN - ASSOCIATED TOXINS FROM BLOOD OF PATIENTS WITH USE OF HIGH FREQUENCY ELECTROMAGNETIC FIELD AND ELECTROSTATIC FIELD DIRECT CURRENT

Device for removing protein-bound toxins from blood plasma

Electroporation device

System and method for mobile generation of nitric oxide

DRUG DELIVERY DEVICE

The present disclosure presents systems, devices and methods for injection of drugs, substances and/or chemicals to a patient and for improving their effectiveness once they are injected are disclosed. Additional treatment can be applied to a tissue region on the patient into which a drug (e.g., insulin) is injected, to expose the tissue region to various forms of energy or a substance to improve the drug's pharmacokinetic and/or pharmacodynamic profile.

IMPLANTABLE MEDICAL DEVICE FOR URGENCY THERAPY THROUGH ELECTRICAL NERVE STIMULATION AND C-AFFERENT NERVE DESENSITIZATION

Systems (10), devices (16), and methods may be used for treating bladder dysfunction, such as urgency and pelvic pain. In one example, a method includes administering a pharmacological agent to a patient (14) in a dosage sufficient to desensitize a C-afferent nerve fiber of the patient. Additionally, the method includes delivering stimulation to activate a nerve fiber proximate to the C-afferent nerve fiber via an electrode (19A, 19B, 21A, 21B, 29A-29D) electrically coupled to an implantable medical device (16). In some examples, the nerve fiber may be different than the C-afferent nerve fiber, the stimulation of the nerve fiber may elicit an inhibitory physiological response related to voiding in the patient, and/or the stimulation substantially may not activate the C-afferent nerve fiber after desensitization of the nerve fiber via the administration of the pharmacological agent.

METHODS AND COMPOSITIONS FOR TREATING A DISEASE CONDITION IN A SUBJECT

Methods for treating a disease condition in a subject are provided. The subject methods are characterizing by enhancing at least one symptom of the disease condition in a manner effective to cause the subject to mount a compensatory response effective to treat the disease condition. Also provided are compositions, kits and systems for practicing the subject methods.

Device and a method for providing resuscitation or suspended state in cardiac arrest

Disclosed is a device for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a patient. The device includes an electrically controllable redistribution component attachable to the patient to provide redistribution of the cardiac output to increase supply to the brain and heart. The redistribution component, following a predefined reaction pattern based on an electrical signal, and computer means configured to: receive a patient data which identifies physiological and/or anatomical characteristics of the patent; and provide the electrical signal for the redistribution component based on the patient data or a standard response. The device may provide mechanisms to protect the aorta and the remaining anatomy of the patient from inadvertent damage caused by the disclosed device in any usage scenario of either correct intended usage or unintended usage. Also disclosed is a method for providing resuscitation or suspended ...

APPARATUS AND METHOD FOR TREATING A NEUROMUSCULAR DEFECT

A method is provided for treating a neuromuscular defect in a subject. One step of the method includes locating a target nerve. After locating the target nerve, a treatment probe is provided. The treatment probe includes an elongated body member having a proximal end portion and a distal end portion. The distal end portion includes an energy delivery mechanism for stimulating or ablating the target nerve, a monitoring mechanism, and a fluid aspiration/delivery mechanism. Next, the target nerve is verified as an appropriate target for ablation by stimulating and then monitoring the target nerve via the energy delivery mechanism and the monitoring mechanism, respectively. After verifying the target nerve, a tumescent fluid is injected into the tissue surrounding the target nerve. An electric current is then delivered to the energy delivery mechanism to substantially ablate the target nerve.

Using alternating electric fields to increase permeability of the blood brain barrier

Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

HIGH FREQUENCY ELECTRONIC DEPILATORY DEVICE

УСТРОЙСТВО ДЛЯ ДОСТАВКИ ЛЕКАРСТВЕННОГО СРЕДСТВА

Изобретение относится к медицинской технике, а именно к устройству доставки лекарственного средства пациенту и, в частности, к устройству для подкожного введения лекарства и использования одного или большего количества терапевтических источников для повышения эффективности введения лекарственных средств. Устройство для доставки терапевтической жидкости пациенту на участке инъекции содержит устройство для инъекции жидкости и терапевтический элемент. Устройство для инъекции жидкости содержит кожух. Кожух содержит инъектор для введения терапевтической жидкости на участке инъекции и резервуар для содержания терапевтической жидкости. Терапевтический элемент присоединен к устройству для инъекции жидкости и выполнен с возможностью применения терапии на участке инъекции и/или вблизи участка инъекции. Терапевтический элемент также выполнен с возможностью улучшения фармакокинетического и/или фармакодинамического свойства терапевтической жидкости либо до, либо во время и/или после инъекции терапевтической ...

УСТРОЙСТВО ДЛЯ ДОСТАВКИ ЛЕКАРСТВЕННОГО СРЕДСТВА

... 1. Устройство для доставки терапевтической жидкости пациенту на участке инъекции, содержащее:кожух, имеющий первый резервуар для содержания терапевтической жидкости и второй резервуар для содержания терапевтического вещества;инъектор для введения терапевтической жидкости на участке инъекции;терапевтический элемент, выполненный с возможностью введения терапевтического вещества на участке инъекции незадолго до, во время и/или после инъекции терапевтической жидкости;причем введенное терапевтическое вещество предназначено для улучшения по меньшей мере одного фармакокинетического и/или фармакодинамического свойства введенной терапевтической жидкости.2. Устройство по п.1, в котором инъектор содержит шприц, или безыгольный шприц, или ручку-инъектор, или любую комбинацию указанных элементов.3. Устройство по п.1, в котором второй резервуар и первый резервуар перед инъекцией расположены в одном кожухе.4. Устройство по п.1, в котором второй резервуар является неотъемлемой частью кожуха.5. Устройство ...

HAEMODIALYSESTIMULATOR

Apparatus and method for improved assisted ventilation

Devices and methods for allowing for improved assisted ventilation of a patient. The methods and devices provide a number of benefits over conventional approaches for assisted ventilation. For example, the methods and devices described herein permit blind insertion of a device that can allow ventilation regardless of whether the device is positioned within a trachea or an esophagus.

Wound therapy device and method

A wound therapy device and method includes a skin contacting element, a reactor, and a reactor housing element. The skin contacting element is configured for covering an associated tissue site, the reactor for creating a pressure condition at the associated tissue site upon actuation thereof, and the reactor housing element for accommodating the reactor. The skin contacting element has a skin contacting side and an interface side, which is opposite the skin contacting side. The reactor housing element has a lower affixing side and an upper side, which is opposite the lower affixing side.

CANCER IMMUNOTHERAPY BY RADIOFREQUENCY ELECTRICAL MEMBRANE BREAKDOWN (RF-EMB)

A system of non-thermally ablating undesirable tissue in the body by application of pulsed, bipolar, instant charge reversal electrical fields of sufficient energy to cause complete and immediate cell membrane rupture and destruction. Energy is delivered through radio frequency pulses of particular frequencies, wave characteristics, pulse widths and pulse numbers, such that enhanced physical stresses are placed on the cell membrane to cause its immediate and complete destruction thereby spilling the entire cell content and membrane constituents into, the extracellular space without denaturing proteins so as to enable an immunological response to destroy and remove the target tissue and similarly marked tissue elsewhere in the subject. *mti 'N Iow *~NNNNNNNNNNNNNNNNNNNNNN 'X''XN'NNNNNNNNNNNNNNNNN'N'NNNNNNNNN)CMO k Ports~P Fig'P9 ...

Systems And Methods For Generating Nitric Oxide

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.

SYSTEMS AND METHODS FOR THE CONDITIONING OF CEREBROSPINAL FLUID

... 5 Systems and methods for treating biologic fluids are disclosed. Some disclosed embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject, heat CSF to a target temperature, cool CSF to a target temperature, apply light treatment to CSF, separate cells via their dielectric properties, apply spiral and/or centrifugal separation, introduce additives to target particles, and/or apply combinations 10 thereof. The method may include the steps of withdrawing fluid comprising CSF, treating the fluid, and returning a portion of the treated fluid to the subject. During operation of the system, various parameters may be modified, such as flow rate.

VENTILATION MACHINE AND METHOD OF VENTILATING A PATIENT

A ventilation machine (1) comprises a conduit interface (12) configured to be connected to a respiratory system of a human or animal patient (5), an air flow generator (11) configured to deliver air through the conduit interface (12) into the respiratory system of the patient (5), a processing unit (3) in communication with the air flow generator (11) and configured to control the airflow generator to deliver air into the respiratory system of the patient (5) according to a breathing scheme, and an induction device (2) for activating a diaphragm of the patient (5). The induction device (2) is in communication with the processing unit (3). The processing unit (3) is configured to control the induction device (2) to activate the diaphragm in coordination with the breathing scheme.

USING ALTERNATING ELECTRIC FIELDS TO INCREASE PERMEABILITY OF THE BLOOD BRAIN BARRIER

Certain substances (e.g., large molecules) that ordinarily cannot traverse the blood brain barrier can be introduced into the brain by applying an alternating electric field to the brain for a period of time, wherein the frequency of the alternating electric field is selected so that application of the alternating electric field increases permeability of the blood brain barrier. In some embodiments, the frequency of the alternating electric field is less than 190 kHz (e.g., 100 kHz). Once the permeability of the blood brain barrier has been increased, the substance is able to cross the blood brain barrier.

TISSUE TREATMENT DEVICE AND METHOD

A controlled pressure device includes a reactor housing element, a reactor, and a cosmetic liquid or cream. The reactor housing element is configured to at least partially define an at least substantially air-tight enclosed volume around a tissue site when fixed in space in relation to the tissue site. The reactor is positioned in the enclosed volume and is configured to react with a selected gas found in air. The reactor consumes the selected gas within the enclosed volume. The cosmetic liquid or cream is also located in the enclosed volume.

INTRACARDIAC DEFIBRILLATION CATHETER

The purpose of the present invention is to provide a defibrillation catheter which can be inserted into a target position within a cardiac cavity along a guide wire and is able to reliably prevent a short circuit between a first lead wire group and a second lead wire group. This defibrillation catheter is provided with: a multi-lumen tube (10); a first DC electrode group (31G); a second DC electrode group (32G); a first lead wire group (41G) comprising lead wires (41) connected to the respective constituent electrodes (31) of the first DC electrode group (31G); and a second lead wire group (42G) comprising lead wires (42) connected to the respective constituent electrodes (32) of the second DC electrode group (32G). The defibrillation catheter applies a voltage between the first DC electrode group (31G) and the second DC electrode group (32G). The multi-lumen tube (10) comprises a center lumen (10L) through which the guide wire can be inserted, and a sub-lumen (11L) and a sub-lumen (12L ...

DEVICES AND METHODS FOR TREATMENT OF VENTILATOR ASSOCIATED DYSPHAGIA

The present invention describes an endotracheal ventilator tube for the treatment of dysphagia comprising an elongate tube and at least one electrode positioned on or about the elongate tube, wherein the at least one electrode is configured to deliver electrical stimulation to the oropharyngeal region and is electrically connected to an electrical stimulation generating means.

ATRIAL DEFIBRILLATION USING AN IMPLANTABLE DEFIBRILLATION SYSTEM

An implantable heart defibrillator for use with an electrode lead system is provided. The implantable heart defibril-lator includes an electrode lead connector that is connectable to the electrode lead system. A sensor is operable to sense a condi-tion of a heart and emit a condition signal that identifies the con-dition. A control unit is operable to identify whether a state of fib-rillation exists from the condition signal and emit a command sig-nal if the state of fibrillation exists. A shock pulse generator is op-erable to emit at least one defibrillation shock to the electrode lead connector upon receipt of the command signal. The at least one defibrillation shock comprises at least one pulse having a voltage of more than 600 volts and a time duration of 30 to 70 mi-croseconds.

SYSTEM AND METHOD FOR WOUND HEALING

A system is provided for healing a wound. The system includes a flexible body, a therapeutic agent delivery mechanism, a suction mechanism, and a power source. The flexible body includes a cover film having oppositely disposed first and second surfaces that define a compartment. The compartment includes a first porous material, a second porous material, and at least one electrode disposed therein. The second porous material is disposed between, the first porous material and the at least one electrode. The therapeutic agent delivery mechanism and the suction mechanism are fluidly connected to the compartment. The power source is in electrical communication with the at least one electrode.

CANCER IMMUNOTHERAPY BY RADIOFREQUENCY ELECTRICAL MEMBRANE BREAKDOWN (RF-EMB)

A method of non-thermally ablating undesirable tissue in the body by application of pulsed, bipolar, instant charge reversal electrical fields of sufficient energy to cause complete and immediate cell membrane rupture and destruction. Energy is delivered through radio frequency pulses of particular frequencies, wave characteristics, pulse widths and pulse numbers, such that enhanced physical stresses are placed on the cell membrane to cause its immediate and complete destruction thereby spilling the entire cell content and membrane constituents into, the extracellular space without denaturing proteins so as to enable an immunological response to destroy and remove the target tissue and similarly marked tissue elsewhere in the subject.

IMPLANTABLE AND REFILLABLE DRUG DELIVERY RESERVOIR

Implantable drug delivery apparatuses and methods are described. An input port septum receives a therapeutic drug. An implantable delivery catheter holds a volume of the therapeutic drug and includes a proximal end in fluid communication with the input port septum, a distal end including an output septum for removing fluid from the catheter, and a drug permeable surface for diffusion of the therapeutic drug into nearby tissue.

SYSTEM AND METHOD FOR DETECTION OF A STIMULATED MOTION REACTION

STIMULATEUR POUR HEMODIALYSE

A.STIMULATEUR POUR HEMODIALYSE. B.STIMULATEUR POUR HEMODIALYSE CARACTERISE EN CE QU'IL COMPORTE AU MOINS DEUX ELECTRODES 1, 2 SONDES OU ELECTRODES-CIBLES FIXEES AU CORPS D'UN PATIENT, CES ELECTRODES ETANT RELIEES PAR L'INTERMEDIAIRE D'UN ECOUTEUR 3 ET PAR L'INTERMEDIAIRE D'UNINSTRUMENT DE MESURE 4 POUR MESURER LA QUANTITE DE COURANT ET LA DERIVATION DE COURANT VERS LA SORTIE D'UN GENERATEUR 5, D'UN SIGNAL ELECTRIQUE, CE GENERATEUR ETANT ALIMENTE A PARTIR D'UNE SOURCE 6 DE COURANT CONTINU. C.L'INVENTION S'APPLIQUE AUX STIMULATEURS POUR HEMODIALYSE.

máquina de ventilação e método de ventilação de um paciente

SYSTEMS AND METHODS OF NEUROMODULATION STIMULATION FOR THE RESTORATION OF SEXUAL FUNCTION

Systems and methods use an external and/or implantable pulse generator system for neuromodulation stimulation to treat sexual dysfunction by the unilateral or bilateral stimulation of a target nerve A and/or a target nerve B using one or more leads and electrodes implanted in tissue in the pelvic region. The electrical stimulation waveform may be conveyed to the target nerve A electrode for a first predetermined amount of time, and conveyed to the target nerve B electrode for a second predetermined amount of time.

Brain and nerve healing power apparatus and method

An apparatus and method is provided for supplying healing power to the brain and nervous system which includes 1) applying a constant magnetic field in a cap or strap arrangement to the head or nervous system of a subject and 2) stimulating the nerves with electric signals applied to neural pathways to the brain located in the hands, feet and other parts of the body, with a view to A) aiding individuals suffering from nervous system disorders including i) serious disorders such as pervasive developmental disorder, autism, disorders caused by hypoxia, trauma and drugs, and some forms of schizophrenia, and also ii) mild disorders such as learning disabilities, and also B) heightening the mental and physical abilities of "normal" people.

Pacer interface device

A method and device for providing a timing signal to a medical device in response to light emitting indicators on a cardiac pacer. The device is optically coupled to the light emitting indicators, but is electrically isolated from the cardiac pacer. A timing signal is generated in response to activation of the light emitting indicators which indicate that an R wave was sensed or a ventricular pace signal was sent.

SUCTION COLLAR FOR ELECTROSURGICAL DEVICES

The invention is an accessory configured to be fitted to an electrical surgical device and provide suction at a surgical site in which the electrical surgical device is being used. In particular, the accessory is in the form of a suction collar configured to be releasably coupled to the electrical surgical device, generally adjacent to a working end thereof, and provide suction to minimize the accumulation of excess steam, fluid, and/or debris from the surgical site during the treatment procedure. The suction collar is further configured to apply a sufficient suction force to a patient's skin surrounding the surgical site to aid in stabilizing the electrosurgical device in place and maintain the working end to the electrosurgical device within the surgical site during the procedure.

Urgency Therapy with Neuromodulation and C-Afferent Nerve Desensitization

Systems (10), devices (16), and methods may be used for treating bladder dysfunction, such as urgency and pelvic pain. In one example, a method includes administering a pharmacological agent to a patient (14) in a dosage sufficient to desensitize a C-afferent nerve fiber of the patient. Additionally, the method includes delivering stimulation to activate a nerve fiber proximate to the C-afferent nerve fiber via an electrode (19A, 19B, 21A, 21B, 29A-29D) electrically coupled to an implantable medical device (16). In some examples, the nerve fiber may be different than the C-afferent nerve fiber, the stimulation of the nerve fiber may elicit an inhibitory physiological response related to voiding in the patient, and/or the stimulation substantially may not activate the C-afferent nerve fiber after desensitization of the nerve fiber via the administration of the pharmacological agent.

Implantable heart treatment systems, devices, and methods

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; and an energy-carrier molecule delivery device coupled to the substrate and configured to supply one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body.

Electrical stimulation of iliohypogastric nerve to alleviate chronic pelvic pain

The disclosure describes a method and system for applying electrical stimulation to an iliohypogastric nerve of a patient. The system includes electrical stimulators that apply electrical stimulation for alleviation of pelvic pain. The system may apply electrical stimulation for pelvic pain in men or women. The electrical stimulators may comprise various types of electrodes such as cuff electrodes, electrode leads, and microstimulators implanted at various locations proximate to a single or both iliohypogastric nerves of a patient. In particular, the electrode may be implanted proximate or adjacent to an anterior cutaneous branch of one or both iliohypogastric nerves, a lateral cutaneous branch of one or both iliohypogastric nerves, or one or both of iliohypogastric nerves above the branch point.

Device and Method for the Ablation of Fibrin Sheath Formation on a Venous Catheter

An indwelling venous catheter and method capable of destroying undesirable cellular growth is provided. The catheter includes a shaft having at least one lumen and adapted to be placed inside a vein for long term use. A plurality of electrodes are positioned near a distal section of the shaft and are adapted to receive from a voltage generator a plurality of electrical pulses in an amount sufficient to cause destruction of cells in the undesirable cellular growth that have grown around the shaft. In one aspect of the invention, a probe is configured to be removably insertable into the at least one lumen and the electrodes are positioned near the distal section of the probe. 1. An indwelling venous catheter capable of destroying undesirable cellular growth comprising:a shaft having at least one lumen and adapted to be placed inside a vein for long term use; anda plurality of electrodes positioned near the shaft and adapted to receive from a voltage generator a plurality of electrical pulses in an amount sufficient to cause destruction of cells in the undesirable cellular growth around the shaft.2. The catheter of . wherein the shaft has two lumens and the electrodes are attached at a distal section of the shaft.3. The catheter of claim 1 , wherein the catheter is a dialysis catheter and the shaft has an arterial lumen and a venous lumen.4. The catheter of claim 1 , further comprising a probe adapted to be removably inserted into the shaft lumen claim 1 , wherein the probe includes at least one of the electrodes.5. The catheter of claim 1 , further comprising:a probe having a lumen and adapted to be removably inserted into the shaft lumen; andat least two electrically conducting elements positioned within the probe lumen and adapted to be movable from a retracted position to a deployed position, wherein a distal section of the electrically conducting elements extend past the distal end of the shaft to define the plurality of electrodes.6. The catheter of claim 5 , ...

System and Method of Coupling Acoustic and Electrical Stimulation of Noninvasive Neuromodulation for Diagnosis and/or Treatment

A system and method of coupling acoustic and electrical stimulation of noninvasive neuromodulation is a therapeutic system and method preferably designed for the diagnosis and/or treatment of neurodegenerative diseases and neurological disorders including, but not limited to, tinnitus, hyperacusis, sleep disorder, depression, anxiety, dizziness, migraine, or ear suffocation. The system includes acoustic signal devices for deep brain electrical stimulation and electrical pulse devices for shallow brain electrical stimulation. Further, the system includes a signal-coupling module that includes an algorithm for coupling acoustic signals to electrical pulses. Parameters of each the acoustic signals and the electrical pulses are adjusted in order for the acoustic signals to be coupled to the electrical pulses. These parameters can also be adjusted based on patient feedback. Furthermore, the system can synchronously output the coupled acoustic signals and the coupled electrical pulses, asynchronously output the acoustic signals, or the electrical pulses based on patient feedback.

Automated External Defibrillator with Integrated Medication Delivery

An automated external defibrillator (AED) system includes shock generating electronics configured to provide at least one electrical shock suitable for a patient experiencing a cardiac event, a battery configured for providing power to the shock generating electronics, power management circuitry configured for managing the shock generating electronics and the battery, a single microprocessor configured for controlling the power management circuitry, and an enclosure configured to house the shock generating electronics, the battery, the power management circuitry, and the single microprocessor. In an embodiment, the AED system includes at least two cardiac pads in electrical connection with the shock generating electronics and including a medication delivery mechanism configured for delivering a predetermined dose of a medication to a patient when the cardiac pads are placed on the patient for shock delivery.

VENTILATION ARRANGEMENT AND TREATMENT METHOD

Устройство для электропорации

Изобретение относится к медицине. Устройство для электропорации предназначено для инъекции лекарственного препарата в цилиарную мышцу глаза. Устройство содержит: опору, имеющую сферическую контактную поверхность опоры, проходящую вдоль воображаемой сферы радиусом от 10 до 15 мм, так чтобы соответствовать наружной поверхности глаза, первый электрод, содержащий по меньшей мере одну инвазивную электродную иглу, второй электрод, имеющий электропроводящую контактную поверхность электрода, по меньшей мере одну инъекционную иглу. Причем опора содержит по меньшей мере одну прямолинейную направляющую вставления, выполненную с возможностью направления вставления указанной по меньшей мере одной инвазивной электродной иглы и/или инъекционной иглы, причем указанная по меньшей мере одна прямолинейная направляющая вставления проходит вдоль соответствующей оси, именуемой «осью вставления» и задающей угол меньше 40° с плоскостью, тангенциальной к воображаемой сфере в точке, в которой ось вставления пересекает ...

ПРЕДСЕРДНАЯ ДЕФИБРИЛЛЯЦИЯ, ИСПОЛЬЗУЮЩАЯ ИМПЛАНТИРУЕМУЮ СИСТЕМУ ДЕФИБРИЛЛЯЦИИ

... 1. Имплантируемый сердечный дефибриллятор для использования с системой электродных отведений, включающий: соединитель электродных отведений, соединяемый с системой электродных отведений; датчик, соединенный с соединителем электродных отведений и выполненный с возможностью определения состояния сердца и подачи сигнала состояния, который идентифицирует состояние; блок управления, связанный с датчиком и выполненный с возможностью определения того, существует ли состояние фибрилляции по сигналу состояния, сигнализации и подачи командного сигнала, если состояние фибрилляции существует; и генератор ударных импульсов, связанный с блоком управления и соединителем электродных отведений, выполненный с возможностью подавать, по крайней мере, один удар дефибрилляции на соединитель электродных отведений после получении командного сигнала, в котором, по крайней мере, один удар дефибрилляции включает, по крайней мере, один импульс, имеющий напряжение более чем 600 вт и продолжительность 30-70 мкс. ! 2 ...

СИСТЕМЫ И СПОСОБЫ ПОЛУЧЕНИЯ ОКСИДА АЗОТА

ПОРТАТИВНЫЙ АППАРАТ ДЛЯ ДЕЗИНФЕКЦИИ ГРУДИ

Группа изобретений относится к медицинской технике, а именно к портативному аппарату для дезинфекции груди и способу дезинфекции груди. Применение этого аппарата снижает риск мастита даже у пациенток, которым свойственна непереносимость к медикаментам. С этой целью аппарат согласно изобретению содержит дезинфицирующее устройство, обеспечивающее дезинфекцию груди по меньшей мере посредством физического метода. 4 н. и 13 з.п. ф-лы, 11 ил.

СРЕДСТВО ОТОБРАЖЕНИЯ ДЛЯ ВЫДАЧИ ИНФОРМАЦИОННОГО КОНТЕНТА МЕДИЦИНСКИХ УСТРОЙСТВ

СИСТЕМЫ И СПОСОБЫ ПОЛУЧЕНИЯ ОКСИДА АЗОТА В АМБУЛАТОРНЫХ УСЛОВИЯХ

Группа изобретений относится к системам для портативного и компактного получения оксида азота (NO). Каждый из вариантов нестационарной системы получения NO включает корпус, пригодный для ношения, контроллер для регулирования оксида азота, получаемого в газе-реагенте, набор электродов высокого напряжения, а также одноразовый картридж, который содержит фильтры и очистители для получения газа, используемого для получения NO, и для очистки выходящих газов перед вдыханием пациентом. Контроллер измеряет резонансную частоту контура высокого напряжения и регулирует частоту и цикл нагрузки сигнала переменного тока для максимизации возбуждения контура высокого напряжения. Системы могут быть использованы с различными устройствами, например аппаратом реанимации, устройством искусственной вентиляции легких, дефибриллятором и др., как в больнице, так и вне её или использоваться самостоятельно. 4 н. и 16 з.п. ф-лы, 65 ил.

Gerät zur Behandlung des menschlichen Körpers

Compositions, systems, kits, and methods for neural ablation

A method for ameliorating pain comprising inserting a cannula to a treatment site of a pain transmitting nerve, introducing an ablation probe (radio frequency), ablating the nerve, and injecting a liquid composition to the treatment site through the canular, where the liquid forms a matrix. The cannula and ablation probe can be cooled (active, passive, cryogenic) during the method. The polymeric matrix can be a solid or a gel, and remains at least 72 hours after injection, and may contain a contrast or imaging agent. The liquid may be a stimuli-responsive biocompatible polymer, and an inverse thermosensitive polymer, and changes from liquid to a gel or solid upon a temperature increase from 4-37 °C. It may be poloxamer (407, 188, 234, 237, 338), poloxamine (1137, 1307) or a combination, with a polyoxyethylene content from 78-85%. It also comprises a system which also includes a syringe to deliver the liquid, which as a viscosity of less than 1000 cP at 4 °C, which increases to at least ...

Devices and methods for treatment of ventilator associated dysphagia

Apparatus and method for improved assisted ventilation

Devices and methods for allowing for improved assisted ventilation of a patient. The methods and devices provide a number of benefits over conventional approaches for assisted ventilation. For example, the methods and devices described herein permit blind insertion of a device that can allow ventilation regardless of whether the device is positioned within a trachea or an esophagus.

Prosthesis management of body physiology

An apparatus, such as an implantable medical device, including an implantable device configured to cause trauma in an inner ear and/or a middle ear recipient. In an exemplary embodiment, the implantable device is a cochlear implant. In an exemplary embodiment, the implantable device is configured to deliver a therapeutic substance to body tissue of the recipient.

THERAPY PROGRAM MODIFICATION BASED ON A THERAPY FIELD MODEL

Techniques for modeling therapy fields for therapy delivered by medical devices are described. Each therapy field model is based on a set of therapy parameters and represents where therapy will propagate from the therapy system delivering therapy according to the set of therapy parameters. Therapy field models may be useful in guiding the modification of therapy parameters. As one example, a processor compares an algorithmic model of a therapy field to a reference therapy field and adjusts at least one therapy parameter based on the comparison. As another example, a processor adjusts at least one therapy parameter to increase an operating efficiency of the therapy system while substantially maintaining the modeled therapy field. 115-. (canceled)16. A method comprising:detecting, by a processor, a patient event of a patient while a medical device is delivering therapy to the patient according to a therapy program determined based on a first reference therapy field applicable to a patient condition of the patient;automatically determining, by the processor and based on the detected patient event, that the first reference therapy field is no longer applicable to the patient condition;determining, by the processor, a second reference therapy field, based on determining that the first reference therapy field is no longer applicable to the patient condition; andadjusting, by the processor, a value of at least one therapy parameter of the therapy program based on the second reference therapy field.17. The method of claim 16 , further comprising claim 16 , prior to detecting the patient event claim 16 , controlling claim 16 , by the processor claim 16 , the medical device to deliver therapy to the patient according to the therapy program.18. The method of claim 16 , wherein the first references therapy field comprises at least one of a stimulation field claim 16 , an electrical field claim 16 , or an activation field with known efficacy for at least one of treating the ...

SELF-CONTAINED HEART PUMP, AND METHOD IMPLEMENTED IN SUCH A PUMP

A heart pump includes: 1. A Heart pump configured to be inserted partly into a systemic ventricle of a heart , through a wall of the heart , the heart pump comprising:a housing configured to be positioned inside the systemic ventricle in such a way as to draw up blood inside the systemic ventricle and to discharge the blood inside the systemic ventricle and through its sigmoid valves of the systemic ventricle,an impeller configured to be inserted inside the housing,a motor connected to the housing,a sealing and fixing membrane fastened to and around the motor and configured to secure the heart pump to the wall of the heart and to partly arrange the motor outside the systemic ventricle,a management unit comprising a power supply, and an impeller control unit; anda wired link between the management unit and the impeller.2. Heart pump according to claim 1 , wherein the sealing and fixing membrane is circular thereby being configured to ensure a complete seal and secure the heart pump to the bottom part of the heart near the apex of the heart.3. Heart pump according to claim 1 , wherein the impeller is of the rotative type and comprises a propeller shaft arranged in the housing.4. Heart pump according to claim 1 , wherein the impeller is of the rotative type and comprises an Archimedes screw or “worm” shaft arranged in the housing.5. Heart pump according to claim 1 , wherein the housing is a longilinear cylinder claim 1 , a side wall of which is perforated in such a way as to enable a discharge of drawn blood claim 1 , and an axis of rotation of which is facing corresponding sigmoid valves.6. Heart pump according to claim 1 , wherein the management unit is biocompatible and is configured to be positioned inside the patient in the epigastric region.7. Heart pump according to claim 1 , wherein at the motor is removable.8. Heart pump according to claim 1 , wherein the power supply comprises at least one rechargeable battery.9. Heart pump according to claim 1 , further ...

METHOD AND APPARATUS FOR AUTOMATED ACTIVE STERILIZATION OF FULLY IMPLANTED DEVICES

The current invention provides this advance in infection control via its unique application of active sterilization to a catheter or implant. While most catheters, and many implants, are passive devices, the current invention will provide an active component as a integral part of the implanted catheter or device to continuously or intermittently sterilize the exposed surfaces/areas of the device. This active sterilization may be accomplished by a variety of mechanisms, including, application of heat, RF, microwave, ultrasound, ultraviolet radiation or other energy capable of sterilizing the device or dislodging any problematic Biofilm that may form. The active sterilization may also employ the pumping of a sterilizing chemical from all attached drug reservoir, the use of electricity or freezing temperatures or any other mechanism for either inhibiting, killing or dislodging any infectious material in contact with the implant. One major advantage of this design is that through the use of small, battery powered or inductively powered sterilization element, the implanted catheter or device can be effectively sterilized without requiring the standard removal surgery, waiting period, then replacement of the infected device. This is expected to translate into greatly improved outcomes (particularly for devices where infection may be catastrophic, ie a prosthetic knee or hip), greatly improved costs, and greatly improved longevity of susceptible devices (ie IV ports, etc.). 1. A sterilization system for sterilizing, an implanted prosthesis, comprising a housing sized for implantation within a patient body and having an energy generator therewithin, wherein the energy generator is configured to deliver anti-infective energy or agents through one or more catheters fluidly coupled to the housing. This application is a continuation of U.S. patent application Ser. No. 121702,977 filed Feb. 9, 2010, which is a continuation of International Pat. App, Ser. No. PCT/US2008/073279 ...

Automatic liquid outlet structure and beauty massage instrument

The present disclosure discloses an automatic liquid outlet structure and a beauty massage apparatus, and the automatic liquid outlet structure comprises a rolling massage mechanism, a liquid storage mechanism, and a liquid adsorption mechanism. The liquid adsorption mechanism is disposed between the rolling massage mechanism and the liquid storage mechanism. A first side of the liquid adsorption mechanism is in communication with the liquid storage mechanism, and a second side of the liquid adsorption mechanism is in contact with the rolling massage mechanism. The liquid storage mechanism is configured to hold a liquid. The liquid held in the liquid storage mechanism is configured to be adsorbed into the liquid adsorption mechanism. When the rolling massage mechanism is in a rolling process, the liquid adsorbed in the liquid adsorption mechanism is transferred to the rolling massage mechanism.

Devices and methods for selectively deploying catheter instruments

Catheters with deployable instruments (e.g., needles) can damage tissue if the instrument unintentionally deploys during use. Described herein are devices and methods for controlling the position of a deployable catheter instrument. In one embodiment, a catheter can include an instrument slidably disposed within an inner lumen of the catheter and coupled to at least one protrusion, as well as a retraction stop coupled to the catheter. The catheter can further include a biasing element coupled to the instrument that can urge the instrument proximally such that the at least one protrusion abuts against the retraction stop, as well as an advancing mechanism to selectively engage the instrument and urge it distally. In some embodiments, the biasing element can be omitted and a deployment stop can be included distal to the retraction stop. These configurations can prevent unintentional instrument deployment and provide greater positioning precision during instrument deployment.

Inhibiting Viral Infection Using Alternating Electric Fields

Viral infections in a target region can be inhibited by imposing an alternating electric field in the target region for a duration of time. The alternating electric field has a frequency and a field strength such that when the alternating electric field is imposed in the target region for the duration of time, the alternating electric field inhibits infection of the cells in the target region by the virus. Optionally, the inhibition of viral infections using the alternating electric field approach can be combined with delivering an antiviral agent to the target region so that a therapeutically effective dose of the antiviral agent is present in the target region while the alternating electric fields are imposed. 1. A method of inhibiting a virus from infecting cells in a target region , comprising the steps of:imposing an alternating electric field in the target region for a duration of time, the alternating electric field having a frequency and a field strength, wherein when the alternating electric field is imposed in the target region for the duration of time, the alternating electric field inhibits infection of the cells in the target region by the virus.2. The method of claim 1 , wherein the target region is a region within a live subject claim 1 , and wherein the alternating electric field is safe for the subject.3. The method of claim 2 , wherein the target region is tumor-free.4. The method of claim 2 , further comprising the step of delivering an antiviral agent to the target region so that a therapeutically effective dose of the antiviral agent is present in the target region while the imposing is performed.5. The method of claim 1 , further comprising the step of delivering an antiviral agent to the target region so that the antiviral agent is present in the target region while the imposing is performed.6. The method of claim 1 , wherein the alternating electric field has a frequency between 50 and 500 kHz.7. The method of claim 1 , wherein the ...

DEVICE, SYSTEM AND METHOD FOR SUBCUTANEOUS DRUG DELIVERY

Embodiments of the present disclosure present systems, methods and devices relate to delivering a drug subcutaneously to a patient. For example, a subcutaneous drug delivery device for use in delivering a drug subcutaneously to a patient can include a needle or cannula configured for delivery of a drug from a drug reservoir to a subcutaneous tissue of a patient. 163-. (canceled)64. A subcutaneous drug delivery device for use in delivering a drug subcutaneously to a patient , the device comprising:a needle or cannula configured for delivery of a drug from a drug reservoir to a subcutaneous tissue of a patient;a treatment element configured to modify delivery of the drug into the circulatory system of the patient by application of a treatment via a surface of skin based on at least one property of the drug and/or at least one property of a drug depot, wherein the drug depot comprises an area of tissue surrounding the needle or cannula;at least one sensor configured to generate at least one signal determinative of the at least one property and generate a sensor signal representative thereof; anda controller to receive the sensor signal and configure treatment by the treatment element based on the at least one property, wherein the at least one property of the drug comprises at least one of a pharmacokinetic and pharmacodynamics profile of the drug.65. The device of claim 64 , wherein the application of treatment includes at least one of the following: heating claim 64 , cooling claim 64 , mechanical vibrations claim 64 , suction claim 64 , massaging claim 64 , acoustic stimulation claim 64 , electromagnetic radiation claim 64 , magnetic stimulation claim 64 , radio frequency irradiation claim 64 , microwave irradiation claim 64 , electrical stimulation claim 64 , Transcutaneous Electrical Nerve Stimulation (TENS) claim 64 , an additional substance claim 64 , drugs claim 64 , medicament claim 64 , chemicals claim 64 , biologically active bacteria claim 64 , biologically ...

System and Method for Motion Detection and Accounting

A stimulation electrode assembly configured to be positioned relative to a patient for an operative procedure is disclosed. An evoked stimulation response may be sensed by a sensor near a portion of a subject. The evoked response may be sensed by an electrode and determined with a monitoring system. The evoked response may additionally and/or alternatively be sensed with a motion sensor. A position sensor may be provided to measure or determine whether the sensor has moved during a procedure. 1. A system to monitor a stimulation reaction in a subject , comprising:a tube having an exterior surface configured to be placed in the subject;a contact connected on the exterior surface and configured to be placed in contact with the subject at a first location, wherein the contact is configured to sense a response to a stimulation; a motion sensing component fixed to the tube relative to the contact, and', 'a motion monitor configured to receive a signal from the motion sensing component to determine motion of the motion sensing component; and, 'a motion sensing system configured to sense motion, including a processor configured to determine a baseline sensed signal and monitor compare a current signal to the determined baseline signal, and', 'a message device to present a message to a user., 'a signal monitoring system configured to receive the sensed response to the stimulation, the monitoring system including2. The system of claim 1 , further comprising:a stimulation electrode configured to transmit a stimulation signal to the subject and evoke a nerve response to be sensed by the contact.3. The system of claim 1 , wherein the message presented by the message device includes a value of a sensed nerve response.4. The system of claim 1 , wherein the motion monitor and the signal monitoring system are integrated as a single monitoring system.5. The system of claim 4 , wherein the processor is configured to further execute instructions to determine motion of the motion ...

METHODS FOR TREATING INFECTIOUS DISEASES

Various methods and devices of treating infectious diseases are described. In one example embodiment, a method of treating an infectious disease in an individual in need thereof is provided, including administering a therapeutic agent to the individual and electroporating a tissue of the individual, wherein the therapeutic agent is inhalable. 1. A method of treating a disease in an individual in need thereof , the method comprising:administering, via inhalation, a therapeutic agent to the individual; andwhile administering the therapeutic agent, electroporating a tissue of the individual to enhance uptake or absorption of the therapeutic agent into the tissue.2. The method of claim 1 , wherein the disease comprises at least one of a viral infectious disease or a bacterial infectious disease.3. The method of claim 1 , wherein the disease comprises at least one of: a coronavirus disease 2019 (COVID-19) claim 1 , Middle East Respiratory Syndrome (MERS) claim 1 , severe acute respiratory syndrome (SARS) claim 1 , viral pneumonia claim 1 , bacterial pneumonia claim 1 , common cold claim 1 , pharyngitis claim 1 , bronchitis claim 1 , broncholitis claim 1 , acute laryngotracheobronchitis claim 1 , tracheitis claim 1 , tracheobronchitis claim 1 , sinusitis claim 1 , and laryngotracheitis.4. The method of claim 1 , wherein the disease comprises at least one of a prion disease or an antimicrobial resistant disease.5. The method of claim 1 , wherein the disease is coronavirus disease 2019 (COVID-19).6. The method of claim 1 , wherein the therapeutic agent is an ion channel blocker.7. The method of claim 6 , wherein the ion channel blocker is a voltage-gated ion channel blocker.8. The method of claim 7 , wherein the voltage-gated ion channel blocker comprises at least one of chloroquine claim 7 , hydroxychloroquine claim 7 , or quinidine.9. The method of claim 6 , wherein the ion channel blocker is a non-voltage-gated ion channel blocker.10. The method of claim 9 , wherein the ...

Systems and Methods for Ambulatory Generation of Nitric Oxide

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula. 126-. (canceled)27. A nitric oxide (NO) system , comprising:a NO source configured to provide a product gas containing nitric oxide; anda controller configured to regulate the amount of NO provided from the NO source using one or more parameters as an input to the controller, the controller being configured to communicate with one or more sensors for detecting timing of an inspiratory event such that the controller is configured to determine timing of a delivery of a pulse of NO delivered to a patient.28. The NO system of claim 27 , wherein the one or more parameters includes information from at least one sensor configured to collect information relating to at least one of the NO source claim 27 , the product gas claim 27 , and a medical gas into which the product gas flows.29. The NO system of claim 27 , wherein the controller is configured to vary one or more of pulse parameters including flow rate claim 27 , duration claim 27 , NO concentration and timing with respect to the inspiratory event.30. The NO system of claim 27 , wherein a duration of the pulse of NO is between tens of milliseconds to an entire duration of the inspiratory event.31. The NO system of claim 27 , wherein the parameters relate to one or more ...

TRANSVASCULAR DIAPHRAGM PACING SYSTEM AND METHODS OF USE

Transvascular diaphragm pacing systems (TDPS) and methods are disclosed for providing respiratory therapy to a patient. The TDPS can provide rapid insertion and deployment of endovascular pacing electrodes in critically ill patients who require intubation and invasive PPMV in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation applied to endovascular electrodes that are temporarily and reversibly inserted in central veins of the patient, such as the left subclavian vein and the superior vena cava. The TDPS can be designed to seamlessly interface with any commercially available positive-pressure ventilatory assistance/support equipment such as is commonly in use in hospital intensive care units (ICU) for treating critically ill patients with breathing insufficiencies, pain, trauma, sepsis or neurological diseases or deficits. 155.-. (canceled)56. A method of stimulating a diaphragm , the method comprising:positioning a first electrode pair of a medical device under skin of a patient proximate at least one phrenic nerve within the patient, the first electrode pair being coupled to a stimulator;providing a flow measurement to the stimulator;determining timing of inspiration of a given breath based on the flow measurement;based on the determined timing of inspiration, delivering electrical stimulation to the first electrode pair with the stimulator to at least partially activate the patient's diaphragm during inspiration of the given breath; andending the electrical stimulation before initiation of a subsequent breath.57. The method of claim 56 , wherein ending the electrical stimulation before initiation of a subsequent breath includes ending the electrical stimulation before initiation of expiration ...

Complex Aqua Skin Peeling Machine

Proposed is a complex aqua skin peeling machine which allows for the use of a handpiece to supply hydrogen water to the skin of a user for removal of reactive oxygen species in the user's body. 1. A complex aqua skin peeling machine , comprising:a main body to which one or more solution containers containing functional cosmetic solutions of different ingredients are detachably coupled;a hydrogen water container coupled to the main body, and to which a hydrogen water module that generates hydrogen water by electrolyzing water therein upon application of electric power is coupled at a lower end thereof;an aqua handpiece including a connector portion connected to a first connection port of the main body, and a head portion to which an aqua tip is replaceably coupled, the aqua tip discharging to a user's skin a functional cosmetic solution for skin cleansing or nourishing supplied from any one of the solution containers and the hydrogen water supplied from the hydrogen water container to remove reactive oxygen species in a user's body, and suctioning the functional cosmetic solution used in skin treatment and skin impurities peeled off from the skin;a waste storage container removably mounted on a side of the main body, and in which the functional cosmetic solution used in skin treatment and the skin impurities peeled off from the skin, which are suctioned through the aqua tip, are stored; anda touch screen controlling an operation of the hydrogen water module, controlling opening and closing of a solenoid valve that controls supply of the functional cosmetic solutions and the hydrogen water to the aqua handpiece from the solution containers and the hydrogen water container, and controlling an operation of the aqua handpiece, in response to a touch input.2. The complex aqua skin peeling machine of claim 1 , further comprising:at least one functional handpiece connected to a second connection port of the main body, and activating cells by massaging the skin by ...

DEVICE FOR TREATING CHRONIC TOTAL OCCLUSION

A catheterization system for treatment of a condition within a blood vessel is provided with a catheter, a balloon immediately adjacent to the distal end of the catheter, an inflation device for expanding the balloon, and a fluid injection device for injecting a treatment fluid through the central lumen of the catheter and out of the aperture at the distal end of the catheter into the treatment area. The system may include an RF wire, a hollow needle wire, a dissection tool, or a laser wire insertable through the central lumen of the catheter and selectively operable adjacent the proximal end of the catheter to apply treatment within the blood vessel. 1. A catheterization system for treatment of a condition within a blood vessel , the system comprising:a support catheter defining a proximal end, a distal end, a central lumen interconnecting the ends, and an aperture at the distal end, the catheter insertable into the blood vessel to a treatment area that is substantially distal of the distal end of the catheter, wherein the central lumen is configured to permit the advancement of a wire therethrough to the treatment area;a flexible membrane mounted on an outside surface of the catheter and disposed immediately adjacent to the aperture at the distal end of the catheter while deflated, the flexible membrane including a proximal end and an opposite distal end, wherein the distal end of the catheter projects slightly beyond the distal end of the flexible membrane when the flexible membrane is fully inflated; wherein the flexible membrane, when inflated, has a substantially cylindrical shape and is positioned to minimize contact between the vessel and a treatment fluid and/or debris;an inflation device selectively operable adjacent the proximal end of the catheter and coupled to the flexible membrane to be capable of expanding the membrane under pressure to create an atraumatic seal with a vessel wall and substantially close off the blood vessel; anda fluid injection ...

System and Method for Motion Detection and Accounting

A stimulation electrode assembly configured to be positioned relative to a patient for an operative procedure is disclosed. An evoked stimulation response may be sensed by a sensor near a portion of a subject. The evoked response may be sensed by an electrode and determined with a monitoring system. The evoked response may additionally and/or alternatively be sensed with a motion sensor. A position sensor may be provided to measure or determine whether the sensor has moved during a procedure.

System for reducing local discomfort

A device for targeted delivery of a substance to an airway may include a conduit and at least two applicators. The conduit may include a proximal end and a bifurcated distal portion having two distal ends. Each applicator may be coupled with one of the distal ends of the conduit and may be configured to direct the substance out of the applicator toward one of two sides of an airway. A method for targeted delivery of a substance to an airway may involve advancing a substance delivery device into the airway, contacting two sides of the airway with at least two applicators of the substance delivery device, such that each applicator contacts the airway near a glossopharyngeal nerve and/or a superior laryngeal nerve on each of the two sides of the airway, and delivering the substance through the applicators to contact the airway along the two sides.

EXPANDABLE ELECTROPORATION DEVICES AND METHODS OF USE

A medical system includes a shaft having a proximal end and a distal end, a balloon attached to the distal end of the shaft, the balloon movable between an expanded state and a deflated state where a maximum diameter of the balloon is greater in the expanded state than in the deflated state, and an electrode is attached to the shaft where a portion of the balloon includes a plurality of apertures fluidly connecting an interior of the balloon to an exterior of the balloon.

PHYSIOLOGICALLY RESPONSIVE VAD

A ventricular assist device incorporating a rotary pump, such as a rotary impeller pump is implantable in fluid communication with a ventricle and an artery to assist blood flow from the ventricle to the artery. The device includes a pump drive circuit supplying power to the pump, one or more sensors for sensing one or more electrophysiological signals such as electrogram signals in and a signal processing circuit connected to the sensors and the pump drive circuit. The signal processing circuit is operative to detect the sensor signals and control power supplied to the pump from the pump drive circuit so that the pump runs in a pulsatile mode, with a varying speed synchronized with the cardiac cycle. When an arrhythmia is detected, the pump drive circuit may also run the pump in an atrial arrhythmia mode or a ventricular arrhythmia mode different from the normal pulsatile mode. 119-. (canceled)20. A ventricular assist device comprising:a rotary pump configured to be implantable in fluid communication with a ventricle and an artery of a subject to assist blood flow from the ventricle to the artery; a pump drive circuit for applying power to the pump;one or more sensors for sensing one or more electrogram signals in a patient;a signal processing circuit in communication with the sensors and the pump drive circuit, the signal processing circuit being operative to receive the electrogram signals from the sensors, and control power supplied to the pump from the pump drive circuit so that in a normal sinus rhythm mode the pump drive circuit varies the power applied to the pump in synchronism with the phases of the cardiac cycle as determined by the electrogram signals, wherein variations of the normal sinus rhythm causes the pump to run with a varying pump speed synchronized with the cardiac cycle.21. A ventricular assist device as claimed in wherein the pump is a rotary impeller pump.22. A ventricular assist device as claimed in claim 20 , wherein the signal processing ...

PHYSIOLOGICALLY RESPONSIVE VAD

A ventricular assist device incorporating a rotary pump, such as a rotary impeller pump is implantable in fluid communication with a ventricle and an artery to assist blood flow from the ventricle to the artery. The device includes a pump drive circuit supplying power to the pump, one or more sensors for sensing one or more electrophysiological signals such as electrogram signals in and a signal processing circuit connected to the sensors and the pump drive circuit. The signal processing circuit is operative to detect the sensor signals and control power supplied to the pump from the pump drive circuit so that the pump runs in a pulsatile mode, with a varying speed synchronized with the cardiac cycle. When an arrhythmia is detected, the pump drive circuit may also run the pump in an atrial arrhythmia mode or a ventricular arrhythmia mode different from the normal pulsatile mode. 1. (canceled)2. A ventricular assist device comprising:an implantable rotary pump including a plurality of operating modes each having a speed;a pump drive circuit for applying power to the pump;a plurality of sensors for sensing a plurality of electrogram signals in a subject; anda signal processing circuit in communication with the pump drive circuit and the plurality of sensors, the signal processing circuit configured to detect an arrhythmia in the subject, classify the arrhythmia according to a type of the arrhythmia, and actuate the pump drive circuit to operate the pump in a select operating mode of the plurality of operating modes in accordance with the type of the arrhythmia.3. The ventricular assist device of claim 2 , wherein the type of the arrhythmia is an atrial arrhythmia and the select operating mode includes a pulsed mode claim 2 , the pulsed mode including the speed being synchronized with a cardiac cycle of the subject using an R-wave.4. The ventricular assist device of claim 2 , wherein the type of the arrhythmia is an atrial arrhythmia and the select operating mode ...

MEDICAL DEVICES AND RELATED METHODS

A medical device includes a shaft including a lumen configured to direct a flow of fluid through the shaft and an electrode. A proximal end of the electrode and a distal end of the shaft form a coupling configured to releasably couple the proximal end of the electrode with the distal end of the shaft. When the proximal end of the electrode is coupled to the distal end of the shaft, fluid delivered through the lumen is emitted from the electrode. 1. A medical device comprising:a shaft including a lumen configured to direct a flow of fluid through the shaft; andan electrode,wherein a proximal end of the electrode and a distal end of the shaft form a coupling configured to releasably couple the proximal end of the electrode with the distal end of the shaft, and wherein when the proximal end of the electrode is coupled to the distal end of the shaft, fluid delivered through the lumen is emitted from the electrode.2. The medical device of claim 1 , wherein the coupling includes one or more arms positioned within the distal end of the shaft.3. The medical device of claim 2 , wherein each of the one or more arms includes a protrusion.4. The medical device of claim 3 , wherein each of the one or more arms further includes at least one of an angled portion at a proximal end of the protrusion and an angled portion at a distal end of the protrusion claim 3 , wherein the at least one angled portion is angled relative to a central longitudinal axis of the distal end of the shaft.5. The medical device of claim 2 , wherein the electrode includes one or more receivers configured to receive the one or more arms.6. The medical device of claim 5 , wherein the one or more receivers is radially wider than a portion of the electrode distal to the one or more receivers claim 5 , and/or than a portion of the electrode proximal to the one or more receivers.7. The medical device of claim 2 , further including one or more seals configured to form a fluid tight seal between the electrode and ...

CHRONIC IMPLANTABLE NEURAL PROBE ARRAY FOR NEURAL SIGNAL ACQUISITION AND STIMULATION

Provided is a neural probe array including a probe which is insertable into a nerve, the probe having a microchannel which induces the regeneration of the nerve, wherein an electrode is installed within the microchannel and is physically isolated from gliosis, and the microchannel is configured to receive a nerve growth factor for regenerating the nerve, and when the probe is inserted into the nerve, the electrode physically isolated from gliosis accomplishes neural signal acquisition and stimulation. 1. A neural probe array , comprising:a probe which is insertable into a nerve, the probe having a microchannel which induces the regeneration of the nerve,wherein an electrode is installed within the microchannel and is physically isolated from gliosis, and the microchannel is configured to receive a nerve growth factor for regenerating the nerve, andwhen the probe is inserted into the nerve, the electrode physically isolated from gliosis accomplishes neural signal acquisition and stimulation.2. The neural probe array according to claim 1 , further comprising:a connecting body to which the probe is coupled, the connecting body having an elastic element formed in a meander shape.3. The neural probe array according to claim 2 , wherein the connecting body is configured to receive a wire electrically connected to the electrode claim 2 , andthe neural probe array further comprises a connector connected to the connecting body, the connector having a terminal electrically connected to the wire.4. The neural probe array according to claim 1 , wherein the microchannel is formed perpendicular to a lengthwise direction of the probe.5. The neural probe array according to claim 1 , wherein the nerve is a peripheral nerve.6. The neural probe array according to claim 1 , wherein the probe comprises:a support forming one surface of the probe;a first member provided on one surface of the support, and having an electrode receiving element in which the electrode is received;a second ...

SYSTEM FOR REDUCING LOCAL DISCOMFORT

A device for targeted delivery of a substance to an airway may include a conduit and at least two applicators. The conduit may include a proximal end and a bifurcated distal portion having two distal ends. Each applicator may be coupled with one of the distal ends of the conduit and may be configured to direct the substance out of the applicator toward one of two sides of an airway. A method for targeted delivery of a substance to an airway may involve advancing a substance delivery device into the airway, contacting two sides of the airway with at least two applicators of the substance delivery device, such that each applicator contacts the airway near a glossopharyngeal nerve and/or a superior laryngeal nerve on each of the two sides of the airway, and delivering the substance through the applicators to contact the airway along the two sides. 1. A device for targeted delivery of a substance to an airway , the device comprising: a conduit comprising a proximal end and a bifurcated distal portion having two distal ends , wherein the proximal end is configured to be coupled with a source of the substance; and at least two applicators , each applicator coupled with one of the distal ends of the conduit , wherein each applicator is configured to direct the substance out of the applicator toward one of two sides of an airway.230-. (canceled) This application is a divisional application of U.S. Nonprovisional application Ser. No. 14/099,233, filed on Dec. 6, 2013, issued as U.S. Pat. No. 9,409,003, which claimed the benefit of U.S. Provisional Patent Application Nos. 61/734,713, entitled “System for Reducing Local Discomfort,” as filed on Dec. 7, 2012; 61/808,142, entitled “System to Reduce Discomfort in the Upper Airway,” as filed Apr. 3, 2013; and 61/823,070, entitled “System to Reduce Discomfort in the Upper Airway,” as filed May 14, 2013. The full disclosures of all the above-referenced applications are hereby incorporated by reference herein.Pain, agitation, gagging ...

Device and a method for providing resuscitation or suspended state in cardiac arrest

Disclosed is a device for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a patient. The device includes an electrically controllable redistribution component attachable to the patient to provide redistribution of the cardiac output to increase supply to the brain and heart. The redistribution component, following a predefined reaction pattern based on an electrical signal, and computer means configured to: receive a patient data which identifies physiological and/or anatomical characteristics of the patent; and provide the electrical signal for the redistribution component based on the patient data or a standard response. The device may provide mechanisms to protect the aorta and the remaining anatomy of the patient from inadvertent damage caused by the disclosed device in any usage scenario of either correct intended usage or unintended usage. Also disclosed is a method for providing resuscitation or suspended state. 1. A device for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a patient , the device comprisingan electrically or manually controllable redistribution component attachable to the patient and being configured to interact with the patient to provide redistribution of the cardiac output to increase supply to the brain and heart, the redistribution component following a predefined reaction pattern based on an electrical signal, and receive a patient data which identifies physiological and/or anatomical characteristics of the patient; and', 'provide the electrical signal for controlling the redistribution component and/or for presenting the physiological and/or anatomical characteristics for a user based on the patient data or a standard response., 'computer means configured to2. The device according to claim 1 , where the computer means comprises memory means having stored therein a ...

Physiologically responsive vad

A ventricular assist device incorporating a rotary pump, such as a rotary impeller pump is implantable in fluid communication with a ventricle and an artery to assist blood flow from the ventricle to the artery. The device includes a pump drive circuit supplying power to the pump, one or more sensors for sensing one or more electrophysiological signals such as electrogram signals in and a signal processing circuit connected to the sensors and the pump drive circuit. The signal processing circuit is operative to detect the sensor signals and control power supplied to the pump from the pump drive circuit so that the pump runs in a pulsatile mode, with a varying speed synchronized with the cardiac cycle. When an arrhythmia is detected, the pump drive circuit may also run the pump in an atrial arrhythmia mode or a ventricular arrhythmia mode different from the normal pulsatile mode.

MEDICAL DEVICES AND RELATED METHODS

A medical device includes a shaft including a lumen configured to direct a flow of fluid through the shaft and an electrode. A proximal end of the electrode and a distal end of the shaft form a coupling configured to releasably couple the proximal end of the electrode with the distal end of the shaft. When the proximal end of the electrode is coupled to the distal end of the shaft, fluid delivered through the lumen is emitted from the electrode. 118-. (canceled)19. A method , comprising:coupling a first electrode with a first structure to a distal end of a medical device shaft, wherein the coupling includes releasably coupling an internal component of the medical device shaft to a portion of the first electrode;uncoupling the first electrode from the distal end; andcoupling a second electrode with a second structure to the distal end, wherein the second structure is different than the first structure.20. The method of claim 19 , wherein uncoupling the first electrode includes an action on a medical device handle coupled to a proximal end of the shaft claim 19 , wherein the action on the medical device handle retracts one or more arms causing the one or more arms to expand and uncouple the arms from a proximal portion of the first electrode.21. The method of claim 20 , wherein the one or more arms are biased radially outward.22. The method of claim 19 , wherein the first electrode includes a first fluid flow path claim 19 , and wherein the second electrode includes a second fluid flow path having a shape different from a shape of the first fluid flow path.23. The method of claim 22 , wherein the first fluid flow path includes a radial flow path claim 22 , and wherein the second fluid flow path extends at an acute angle relative a central longitudinal axis of the distal end of the medical device shaft.24. The method of claim 19 , wherein the first electrode includes a first insulation pattern claim 19 , and wherein the second electrode includes a second insulation ...

PHYSIOLOGICALLY RESPONSIVE VAD

A ventricular assist device incorporating a rotary pump, such as a rotary impeller pump is implantable in fluid communication with a ventricle and an artery to assist blood flow from the ventricle to the artery. The device includes a pump drive circuit supplying power to the pump, one or more sensors for sensing one or more electrophysiological signals such as electrogram signals in and a signal processing circuit connected to the sensors and the pump drive circuit. The signal processing circuit is operative to detect the sensor signals and control power supplied to the pump from the pump drive circuit so that the pump runs in a pulsatile mode, with a varying speed synchronized with the cardiac cycle so that it operates in copulsation or counterpulsation with the cycle. The cardiac cycle for purposes of synchronization can also be based on an average of two or more cardiac cycles. 1. A ventricular assist device comprising:a rotary pump configured to be implantable in fluid communication with a ventricle and an artery of a subject to assist blood flow from the ventricle to the artery;a pump drive circuit for applying power to the pump;one or more sensors for sensing one or more electrogram signals in a patient; anda signal processing circuit in communication with the sensors and the pump drive circuit, the signal processing circuit being operative to receive the electrogram signals from the sensors, and control power supplied to the pump from the pump drive circuit so that in a normal pulsatile mode the pump drive circuit varies the power applied to the pump in synchronism with the cardiac cycle as determined by the electrogram signals, and such variation causes the pump to run with a varying speed synchronized with the cardiac cycle of the subject so that the pump speeds up and slows down during each cardiac cycle,wherein the varying speed is synchronized with the cardiac cycle so that the pump operates at a maximum speed during ventricular diastole.2. The ...

Modular Extracorporeal Systems and Methods for Treating Blood-Borne Diseases

Extracorporeal systems and methods for treating blood-borne diseases in a subject or for developing drugs to treat blood-borne diseases include various environmental and treatment modules that can be tailored to a specific disease or infection. In certain embodiments of the systems and methods, a blood sample is treated with cold plasma and optionally with hydrostatic pressure, a pulsed electrical field, a pharmaceutical agent, microwave, centrifugation, sonification, radiation, or a combination thereof, under environmental conditions that are effective for the treatment.

Concepts for catheter control and stabilization

A catheter guide device configured to facilitate precise placement of a downstream end of a catheter within a patient. The catheter guide device comprises a torque assembly configured to frictionally engage an exterior surface of a catheter and a hub configured to engage a catheter sheath and thereby prevent rotation of the catheter sheath relative to the hub. The torque assembly is rotatably secured to the hub such that rotating the torque assembly relative to the hub rotates the catheter relative to the catheter sheath and thereby moves the downstream end of the catheter within the patient. The hub additionally comprises a detent mechanism configured to engage a plurality of gear teeth on an exterior surface of the torque assembly to thereby impede unintended rotation of the torque assembly relative to the hub.

REMOVABLE MANDIBULAR PHARMACEUTICAL DELIVERY DEVICE

An oral appliance for the treatment of sleep disorders, such as obstructive sleep apnea, in a user is presented. The oral appliance may include a mouthpiece configured to receive a user's dentition. The mouthpiece may include an oxygen sensor, a pressure sensor, an airflow sensor, an actigraphy sensor, a noise detector, and at least one stimulator for providing stimulation to a user's tongue in the event of decreased oxygen saturation levels, increased pressure applied to occlusal surfaces of the user's dentition, decreased actual airflow levels and/or increased noise levels. The mouthpiece may be provided with pharmaceutical compound reservoirs that deliver pharmaceutical compounds to the oral mucosa of the user, which compounds treat symptoms of sleep apnea. The mouthpiece may further include a microprocessor that receives data from the oxygen sensor, pressure sensor, airflow sensor, actigraphy sensor and noise detector, and activates the at least one stimulator and/or pharmaceutical compound reservoirs. 1. An oral appliance for treatment of sleep apnea in a user , comprising:a mouthpiece configured to be retained in the mouth of the user, the mouth of the user comprising oral tissue and the mouthpiece having a lingual wall and a buccal wall;one or more reservoirs arranged on either or both of the lingual wall or the buccal wall, each reservoir containing a pharmaceutical compound;at least one sensor attached to the mouthpiece and configured to measure a relevant symptom to an immediate presence of sleep apnea in the user; and 'the stimulator is configured for emitting an electrical current or field in response to the immediate presence of sleep apnea in the user based on the relevant symptom measured by the at least one sensor, wherein the electrical current or field results in dispensing of the pharmaceutical compound from the reservoir.', 'at least one electrical stimulator attached to the mouthpiece, wherein'}2. The oral appliance of claim 1 , wherein the ...

Means and Method to Invade Skin, Mucosa, and Underlying Tissues with Little or No Pain

A means and a method is disclosed to diminish or eliminate the pain associated with a sharp object penetrating the skin, during such procedures as an injection, biopsy, or deriving a blood sample. To this end, repeated tapping, pressing, or rubbing or vibrating is performed over the skin at or near the site of penetration of the sharp object in conjunction with applying electricity on the skin. The invention discloses a method of using a skin-puncturing means, with enhanced features, to provide local anesthesia at the site of penetration of a sharp object. 118-. (canceled)19- A method of painless or near painless injection comprising:a) applying electricity through a plurality of electrodes at least before, during, or after an injection to an injection site, andb) applying gas to said injection site through an applicator of gas at least before, during, or after an injection to said injection site.20- The method according to wherein said gas dries or blows away a disinfectant that has been applied to said injection site.21- The method according to wherein said gas is air.22- The method according to wherein said disinfectant has a boiling point selected to impart a cold sensation when said air blows on said disinfectant.23- The method according to wherein said applying gas comprises pressing at least one of said electrodes on the skin.24- The method according to wherein said applying electricity comprises pressing at least one of said electrodes on the skin.25- The method according to wherein said gas blows from a can containing compressed gas.26- The method according to wherein said injection is delayed for a predetermined amount of time after the termination of said blowing gas to the injection site.27- The method according to wherein said delay is no greater than one minute.28- The method according to wherein said delay is at least one minute.29- The method according to wherein said gas blows in discrete bursts.30- The method according to whereina) Said bursts of ...

Systems and methods for generating nitric oxide

Systems and methods for nitric oxide generation are provided. In an embodiment, an NO generation system can include a controller and disposable cartridge that can provide nitric oxide to two different treatments simultaneously. The disposable cartridge has multiple purposes including preparing incoming gases for exposure to the NO generation process, scrubbing exhaust gases for unwanted materials, characterizing the patient inspiratory flow, and removing moisture from sample gases collected. Plasma generation can be done within the cartridge or within the controller. The system has the capability of calibrating NO and NO2 gas analysis sensors without the use of a calibration gas.

METHODS FOR THERAPEUTIC TARGETING OF CIRCULATING TUMOR CELLS DURING HEMODIALYSIS

The present invention is directed towards methods for therapeutically targeting circulating tumor cells during hemodialysis. 1. A method for therapeutically targeting circulating tumor cells during hemodialysis , the method comprising:detecting circulating tumor cells from extracorporeal blood;reducing the viability of the circulating tumor cells, wherein the step of reducing the viability of the circulating tumor cells generates circulating tumor cell debris and excess chemotherapeutic reagents; andremoving the circulating tumor cell debris and the excess chemotherapeutic reagents via dialysis.2. The method of claim 1 , wherein the circulating tumor cells have an increased amount of intracellular lipid accumulation compared to the non-circulating tumor cells.3. The method of any one of the previous claims claim 1 , wherein the circulating tumor cells have higher levels of lipid metabolism proteins compared to the non-circulating tumor cells.4. The method of any one of the previous claims claim 1 , wherein the viability of the circulating tumor cells is reduced by suppressing lipid metabolism of the circulating tumor cells with a small interfering RNA (siRNA).5. The method of claim 4 , wherein the siRNA interferes with lipid metabolism proteins selected from the group consisting of acyl-CoA cholesterol acyltransferase 1 (ACAT1) claim 4 , adiponutrin claim 4 , 1-acylglycerol-3-phosphate o-acyltransferase 2 (AGPAT2) claim 4 , adipose triglyceride lipase (ATGL) claim 4 , zinc-alpha-2-glycoprotein (AZGP1) claim 4 , cell death inducing DNA fragmentation factor proteins (CIDEA claim 4 , CIDEB and CIDEC/FSP27) claim 4 , comparative gene idenfitication-58 (CGI-58) claim 4 , CTP phosphocholine cytidylyltransferase (CCT) claim 4 , acyl-CoA diacylglycerol acyltransferase (DGAT1 and DGAT2) claim 4 , hormone sensitive lipase (HSL) claim 4 , lipin1 claim 4 , PAT proteins claim 4 , triacylglycerol hydrolase (TGH) claim 4 , fatty acid binding proteins (FABP 1-9) claim 4 , fatty ...

Methods and Compositions for Treating a Disease Condition in a Subject

Methods for treating a disease condition in a subject are provided. The subject methods are characterizing by enhancing at least one symptom of the disease condition in a manner effective to cause the subject to mount a compensatory response effective to treat the disease condition. Also provided are compositions, kits and systems for practicing the subject methods.

DISPLAY FOR OUTPUTTING INFORMATION CONTENTS OF MEDICAL DEVICES

A display for outputting information contents of at least one parameter, adjustment value or measurement value of medical devices within at least one display region, wherein the at least one display region is in the form of a tachometer-like display. 119-. (canceled)20. A display for outputting information contents of at least one parameter , adjustment value or measurement value of a medical device the display comprising at least one display region formed as a tachometer-like display.21. The display according to claim 20 , wherein the tachometer-like display includes at least one needle and at least one panel containing values claim 20 , measurement values or measurement value ranges.22. The display according to claim 21 , wherein the tachometer-like display is operatively configured to implement an output of information contents of at least one parameter claim 21 , adjustment value or measurement value of medical devices by a change of position of the at least one needle relative to the panel containing values claim 21 , measurement values or measurement value ranges.23. The display according to claim 21 , wherein the change in position of the at least one needle relative to the panel containing values claim 21 , measurement values or measurement value ranges takes place due to a movement of the needle and/or of the panel.24. The display according to claim 23 , wherein motion kinematics for the relative position change follow a rotary trajectory.25. The display according to claim 24 , wherein the panel containing values claim 24 , measurement values or measurement value ranges is arranged in a semi-circular manner within the display region.26. The display according to claim 22 , wherein the output of information content of at least one parameter claim 22 , adjustment value or measurement value of medical devices is realized additively by the display of the numerical value.27. The display according to claim 20 , wherein the display is a display or monitor or ...

SYSTEM AND METHODS FOR OVERDOSE MITIGATION

Systems and methods for mitigating or preventing opioid overdoses are disclosed herein. More specifically, an overdose mitigation system includes an overdose sensor, such as a pulse oximeter, that is strapped around a user's arm in a similar manner as a blood pressure cuff. The system measures an overdose indicator, such as a minimum oxygen saturation level. When the indicator is detected, the system sounds an alarm and automatically injects an opioid antidote (e.g., intramuscularly), via an attached injector with a reservoir containing the antidote, unless an input is received from a user interface. Thus, systems and methods disclosed herein allow for an antidote to be automatically delivered to a user at risk of death from overdose, without having to wait on a first responder or rely on a caregiver. 1. A narcotic overdose mitigation system for a person comprising:an injector coupled with a reservoir, the reservoir containing a narcotic antidote;an overdose sensor configured to detect an overdose indicator for the person; anda processor coupled to a user interface, and the injector and configured to, wait a predetermined amount of time, and', 'actuate the injector unless an input is received from the user interface., 'in response to detection of the overdose indicator,'}2. The overdose mitigation system of claim 1 , further comprising an alarm claim 1 , wherein the alarm is actuated in response to the overdose indicator.3. The overdose mitigation system of claim 1 , wherein the predetermined amount of time comprises zero or more seconds.4. The overdose mitigation system of claim 1 , wherein the narcotic antidote is Narcoxone.5. The overdose mitigation system of claim 1 , wherein the overdose sensor is a pulse oximeter and the overdose indicator is an oxygen saturation level.6. The overdose mitigation system of claim 2 , wherein the alarm is a speaker and actuation of the alarm comprises an audible alert.7. The overdose mitigation system of claim 1 , wherein the ...

System and method for treating surfaces of bodies, in particular for wound treatment

Furthermore, the invention relates to a method for treating surfaces of bodies by means of the system according to the invention, wherein a body with a surface to be treated is provided, the system for treating surfaces of bodies is provided, a negative pressure is generated in a space positioned on the surface of the body and the space is filled at least partly with plasma or plasma-activated medium.

COUPLED ANNULUS AND CATHETER SYSTEM FOR PLACEMENT OF BIOCOMPATIBLE BRAIN ELECTRODES AND LIKE DEVICES

A system for placement of biocompatible electrodes in an opening formed in a patient's body part, such as DBS electrodes inserted into a patient's skull during surgical procedures in the brain. The system includes a coupled catheter and annulus. The catheter includes a guide tube having at least three cooperating guide elements configured to releasably fit together and collectively form a continuous lumen through the catheter that is dimensioned to receive an electrode therein. The annulus is configured to be placed in the opening formed in the patient's body part, and to receive the catheter therethrough. A track mechanism is used to operably couple the catheter to the annulus. 1. A system for placement of biocompatible electrodes in an opening formed in a patient's body part , comprising: each of the guide elements including a first end, a second end, a plurality of rotatably-connected segments extending between the first and second ends, and a plurality of joints connecting adjacent ones of the segments;', 'the guide elements being configured to releasably fit together and collectively form a continuous lumen through the catheter, the lumen extending along the longitudinal axis of the guide tube and being dimensioned to receive an electrode therein;, 'a catheter including a guide tube, the guide tube having a longitudinal axis and at least three guide elements extending along the longitudinal axis;'}an annulus including a circumferential rim defining an interior circular space that is dimensioned to receive the catheter therethrough, and a number of legs engaging the rim and extending outwardly therefrom, the annulus being configured to be secured in the opening;and means for operably coupling the catheter to the annulus.2506. The system of claim 1 , wherein the catheter is moveable between a first claim 1 , united cylindrical configuration with each one of the guide elements of the guide tube being fully interconnected to the others of the guide elements claim 1 ...

METHODS, SYSTEMS, AND APPARATUSES FOR DELIVERY OF ELECTROLYSIS PRODUCTS

Example apparatuses and systems are disclosed for providing controlled delivery of electrolysis products to a site which may be used for treatment of infection and ablation of undesirable cells and tissue. A system disclosed may include a power supply, two electrodes, an aqueous matrix that may close the electric circuit between the electrodes at the treated site, and a controller. The controller may control the electrical circuit to induce a direct current through the electrodes and an aqueous matrix to produce electrolysis products. The duration and magnitude of the charge applied may determine the dose of the products applied to the treatment site. The composition of the electrodes and the aqueous matrix may be chosen to produce desired products. An apparatus is disclosed that may be in the form of a pad for applying to a wound. An apparatus is disclosed that may be used for treating internal tissue. 1. (canceled)2. A method for delivering electrolysis products to a site , the method comprising:using a controller, generating an electrical signal indicative of a timing and dose of the electrolysis products; andproviding the electrical signal to a device proximate the site, wherein the device is configured to generate the electrolysis products proximate the site responsive to the electrical signal.3. The method of claim 2 , wherein the device comprises at least one electrode and an aqueous matrix claim 2 , wherein the electrolysis products are generated in the aqueous matrix responsive to the electrical signal applying a current through the aqueous matrix.4. The method of claim 2 , wherein the device comprises a pad claim 2 , and wherein the method further comprises applying the pad to the site.5. The method of claim 2 , wherein the device comprises a pad claim 2 , and wherein the method further comprises implanting the pad proximate the site.6. The method of claim 2 , wherein the device comprises one of a surface pad claim 2 , luminal catheter claim 2 , or a ...

AUTOIMMUNE MECHANICAL IMMUNOMODULATION

The present disclosure describes a novel therapeutic apheresis system and, more specifically, methods and an apparatus for performing therapeutic apheresis. The present disclosure provides highly efficient methods for therapeutic apheresis that modulate the immune system, thereby resulting in treatment of one or more underlying immunological disease processes. In some embodiments, the disclosed methods return at least a portion of blood from an extracorporeal circuit to a patient in pulsatile flow, where the portion of blood that is returned is augmented. In other embodiments, the disclosed methods and apparatus use the central arterial system to exchange volumes of plasma to immunomodulate disease processes. The disclosed methods combine concepts of intermittent flow and continuous flow therapeutic apheresis with established cardiovascular concepts. In addition, the disclosed methods reduce the amount of time spent by patients in therapeutic apheresis sessions and decrease patients' dependence on immunological drugs that may have detrimental adverse effects. 1. A method of performing therapeutic apheresis comprising the steps of:a. introducing arterial blood from a patient into an extracorporeal circuit;b. performing apheresis on the blood to remove one or more components from the blood; andc. returning a portion of the blood from the extracorporeal circuit to the patient in pulsatile flow.2. The method of claim 1 , wherein the extracorporeal circuit comprises one or more of an automated blood cell separator claim 1 , a pump claim 1 , a sensor claim 1 , and a heat exchanger.3. The method of claim 1 , wherein one or more pumps create the pulsatile flow.4. The method of claim 1 , wherein the pulsatile flow is created by a pulse wave from the patient5. The method of claim 1 , wherein the portion of the blood includes a replacement fluid.6. The method of claim 5 , wherein the replacement fluid comprises a therapeutic agent.7. The method of claim 1 , wherein the ...

SYSTEM, DEVICE AND METHOD FOR AUTOMATED TREATMENT OF SYMPTOMS ASSOCIATED WITH NERVE GAS EXPOSURE

Systems and methods for treating nerve agent exposure in a person are disclosed. Specifically, systems and methods for detecting with sensor(s) the presence of a nerve gas in the vicinity of a person and/or symptoms in a person as a result of exposure to nerve gas, followed by actuation of an alarm and automatic initiation of a programmed injection sequence comprising at least one injection of a nerve gas antidote comprising at least one of atropine, an anticholinesterase reactivator such as 2-PAM and an anti-convulsant such as diazepam. 1. A nerve agent treatment system for a person comprising:at least one injector coupled with at least one reservoir, the at least one reservoir containing the group consisting of atropine, an acetylcholinesterase reactivator, and an anticonvulsant;at least one sensor configured to detect the presence of nerve gas in the person's immediate vicinity and/or nerve gas exposure symptoms exhibited by the person; anda processor coupled to a user interface and adapted to execute a programmable injection sequence of the at least one injector, and the at least one injector and configured to actuate the at least one injector in the programmed injection sequence in response to the detection of the presence of nerve gas and/or nerve gas exposure symptoms.2. The nerve gas treatment system of claim 1 , further comprising an alarm claim 1 , wherein the alarm is actuated in response to the detection of the presence of nerve gas and/or nerve gas symptoms.3. The nerve gas treatment system of claim 2 , further comprising a predetermined amount of time immediately following actuation of the alarm and wherein the predetermined amount of time comprises zero or more seconds.4. The nerve gas treatment system of claim 3 , further comprising automatic actuation of the programmed injector sequence unless an input is received from the user interface.5. The nerve gas treatment system of claim 1 , further comprising:a first reservoir containing atropine and in ...

Respiratory apparatus and method of operating the respiratory apparatus

There is provided a respiratory apparatus. The respiratory apparatus comprises a respiratory interface configured to aid a user in respiration and an attachment configured to hold the respiratory interface in position on the face of the user. The respiratory apparatus also comprises at least one electrode configured to provide electrical stimulation to one or more facial muscles of the user. 1. A respiratory apparatus comprising:a respiratory interface configured to aid a user in respiration;an attachment configured to hold the respiratory interface in position on the face of the user;at least one electrode configured to provide electrical stimulation to one or more facial muscles of the user; andat least one sleep stage sensor configured to acquire a signal indicative of a sleep stage of the user, and wherein the at least one electrode is controllable to provide electrical stimulation to the one or more facial muscles of the user when the acquired signal is indicative of the user sleeping.2. A respiratory apparatus as claimed in claim 1 , wherein the attachment comprises at least one strap claim 1 , or at least one adhesive member.3. A respiratory apparatus as claimed in claim 1 , wherein the attachment comprises the at least one electrode.4. A respiratory apparatus as claimed in claim 1 , comprising:at least one pair of electrodes, the at least one pair of electrodes configured to provide electrical stimulation to corresponding muscles on each side of the face of the user.5. A respiratory apparatus as claimed in claim 1 , wherein the one or more facial muscles of the user comprise any one or more of:a zygomaticus major muscle of the user; andan orbicularis oculi muscle of the user.6. A respiratory apparatus as claimed in claim 1 , wherein the at least one sleep stage sensor comprises any one or more of:a physiological characteristic sensor;an eye movement sensor; andan activity sensor.7. A respiratory apparatus as claimed in claim 1 , wherein the at least one ...

Implantable heart treatment systems, devices, and methods

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; and an oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion.

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate; an electromagnetic signal generator configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; a metabolic molecule supply device configured to supply one or more metabolic molecules to one or more tissues of the heart; and control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, dependent upon a status of a ventricular fibrillation event of the heart. 143.-. (canceled)44. A method of treating a heart with an implanted heart treatment device , comprising:generating, via a heart treatment device implanted within a body of a biological subject, one or more electric signals configured to stimulate one or more tissues of a heart within a body during a fibrillation event of the heart according to a first control protocol and a second control protocol;administering the one or more electric signals to the one or more tissues of the heart according to the first control protocol and the second control protocol; anddelivering, via the heart treatment device, one or more metabolic molecules to one or more tissues of the heart, after the fibrillation event has proceeded for a duration sufficient to exhaust the myoglobin-based oxygen of the heart according to the second control protocol.45. The method of claim 44 , wherein the one or more metabolic molecules include one or more oxygenated molecules.46. The method of claim 44 , wherein the one or more metabolic molecules include iodide or salts thereof.47. The method of claim 44 , further comprising:storing the one or more metabolic molecules in the heart treatment device in vivo.48. The method of claim 44 , wherein generating ...

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; and an energy-carrier molecule delivery device coupled to the substrate and configured to supply one or more non-oxygen cellular energy sources to one or more tissues of the heart within the body. 143.-. (canceled)44. A method of treating a heart with an implanted heart treatment device , comprising:generating, via a heart treatment device implanted within a body of a biological subject, one or more electric signals configured to stimulate one or more tissues of a heart within a body during a fibrillation event of the heart;administering the one or more electric signals to the one or more tissues of the heart; anddelivering, via the heart treatment device, one or more non-oxygen cellular energy sources to one or more tissues of the heart, after the fibrillation event has proceeded for a duration sufficient to exhaust the myoglobin-based oxygen of the heart.45. The method of claim 44 , wherein the one or more non-oxygen cellular energy sources include at least one of adenosine triphosphate (ATP) claim 44 , cyclic adenosine monophosphate (cAMP) claim 44 , adenosine monophosphate (AMP) claim 44 , adenosine diphosphate (ADP) claim 44 , creatine claim 44 , and cyclocreatine.4648.-. (canceled)49. The method of claim 44 , further comprising:storing the one or more non-oxygen cellular energy sources molecules in vivo.50. The method of claim 44 , further comprising:storing the one or more non-oxygen cellular energy sources in a reservoir of the heart treatment device.51. The method of claim 44 , wherein the one or more more non-oxygen cellular energy sources are positioned within one or more carrier ...

APPARATUS FOR DELIVERY OF PHARMACEUTICALS TO THE COCHLEA

An implantable electrode array assembly configured to stimulate tissue of a recipient, including an elongate member configured to be inserted into a recipient, wherein at least a portion of the elongate member includes a bio-active substance. 1. A stimulating medical device , comprising:an implantable electrode array assembly implantable proximate to nerve cells of a recipient having at least one substance egress and a plurality of electrodes;stimulator unit configured to generate electrical stimulation signals for application to a first population of the nerve cells via one or more of the plurality of electrodes;a bioactive substance source configured to provide a bioactive substance to the at least one substance egress for application to a second population of the nerve cells; anda substance delivery mechanism configured to control one or more of the bioactive substance source and the at least one substance egress to cause selective application of the bioactive substance to the second population of nerve cells.2. The stimulating medical device of claim 1 , wherein the substance delivery mechanism is configured to cause application of the bioactive substance to the second population of nerve cells in order elicit a change in the transmembrane potential of the second population of nerve cells.3. The stimulating medical device of claim 2 , wherein the substance delivery mechanism is configured to cause application of the bioactive substance to the second population of nerve cells in order reduce the resting potential of the nerve cells.4. The stimulating medical device of claim 2 , wherein the substance delivery mechanism is configured to apply the bioactive substance to the second population of nerve cells in order to facilitate restoration of a stochastic response of the second population of nerve cells.5. The stimulating medical device of claim 4 , wherein the substance delivery mechanism is configured to cause application of the bioactive substance to the second ...

Remote closed-loop titration of decongestive therapy for the treatment of advanced heart failure

An apparatus comprises one or more physiological sensing circuits that generate a sensed physiological signal and at least one of the physiological sensing circuits is implantable, a measurement circuit configured to recurrently measure one or more physiological parameters that indicate a status of heart failure of the subject, a comparison circuit configured to compare the one or more physiological parameter measurements to one or more physiological parameter target values, a therapy circuit configured to control delivery of one or more drugs to treat heart failure, and a control circuit in electrical communication with the comparison circuit and the therapy circuit and configured to recurrently adjust delivery of drug therapy according to the comparison of the measured physiological parameters to the physiological parameter targets.

DEVICES AND METHODS FOR TREATMENT OF VENTILATOR ASSOCIATED DYSPHAGIA

The present disclosure describes an endotracheal ventilator tube for the treatment of dysphagia comprising an elongate tube and at least one electrode positioned on or about the elongate tube, wherein the at least one electrode is configured to deliver electrical stimulation to the oropharyngeal region and is electrically connected to an electrical stimulation generating means. 1. An endotracheal ventilator tube for the treatment of dysphagia comprising:an elongate tube; andat least one electrode positioned on or about the elongate tube,wherein the at least one electrode is configured to deliver electrical stimulation to the oropharyngeal region and is electrically connected to an electrical stimulation generating means.2. The endotracheal ventilator tube according to claim 1 , wherein the elongate tube is changeable between a first configuration claim 1 , in which it has a first shape claim 1 , and a second configuration claim 1 , in which it has a second shape claim 1 , different to the first.3. The endotracheal ventilator tube according to claim 1 , further comprising a sleeve selectively positionable around the elongate tube claim 1 , wherein the at least one electrode is positioned on the sleeve.4. The endotracheal ventilator tube according to claim 3 , wherein the sleeve is split longitudinally along its length.5. The endotracheal tube according to claim 4 , wherein the at least one electrode is formed from a flexible printed conductive material.6. The endotracheal ventilator tube according to claim 2 , wherein the elongate tube is resiliently biased in a pre-curved configuration.7. An endotracheal ventilator tube comprising an elongate tube claim 2 , wherein the elongate tube comprises at least one channel for receiving a catheter.8. (canceled)9. A method of treating ventilator associated or neurogenic dysphagia claim 2 , the method comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'inserting a ventilation tube as claimed in into a patient, either ...

Percutaneous Electrical Phrenic Nerve Stimulation System

A percutaneous electrical phrenic nerve stimulation (PEPNS) system that measures the patient Work of Breathing (WOB) of each type of ventilator breath and determines when to deliver electrical stimulus based upon the measured WOB. The PEPNS system alters its behavior based upon the type and origin of the ventilator breath delivered and provides warnings for certain identified interactions between the ventilator and the patient.

Catheter with Plurality of Sensing Electrodes Used as Ablation Electrode

A system includes a switching assembly and a processor. The switching assembly is connected to multiple electrodes that are disposed on an expandable distal end of a catheter, and is configured to switch the electrodes between a position tracking system, an electrophysiological (EP) sensing module and a generator of an ablative power. The processor is configured to control the switching assembly to switch the electrodes. 1. A system , comprising:a switching assembly, which is connected to multiple electrodes that are disposed on an expandable distal end of a catheter, the switching assembly configured to electrically connect the electrodes to electrically connect to one of a position tracking system, an electrophysiological (EP) sensing module and a generator of an ablative power; anda processor, which is configured to control the switching assembly to switch the electrodes.2. The system according to claim 1 , wherein the ablative power comprises at least one of a radiofrequency (RF) power outputted by an RF generator and irreversible electroporation (IRE) pulses outputted by an IRE pulse generator.3. The system according to claim 1 , wherein each of the electrodes comprises a plurality of electrode segments.4. The system according to claim 3 , wherein:when connecting a given electrode to the position tracking system or to the EP sensing module, the switching assembly and the processor are configured to connect each of the electrode segments of the given electrode individually; andwhen connecting the given electrode to the generator of the ablative power, the switching assembly and the processor are configured to jointly connect all the electrode segments of the given electrode.5. The system according to claim 1 , wherein the processor is configured to control whether to use the electrode as a position sensor claim 1 , as an EP sensor claim 1 , or as an ablation electrode claim 1 , by evaluating a preset impedance criterion.6. The system according to claim 5 , ...

Treatment apparatus and method of controlling same

The present invention relates to a treatment apparatus and a method of controlling the same, and provides a treatment apparatus including an insertion unit formed in such a way as to be inserted into a tissue through a tissue surface, a bending sensing unit sensing bending of the insertion unit occurring during insertion, and a controller controlling the insertion operation of the insertion unit based on information sensed by the bending sensing unit, and a method of controlling the same. In accordance with the present invention, there is an advantage in that a treatment effect can be improved because treatment can be performed in the state in which the insertion unit has been inserted into an accurate target location.

Methods and Apparatus for Inducing or Modifying Sleep

A neuromodulator may output stimuli that causes a user to fall asleep faster than the user would in the absence of the stimuli. Alternatively, the stimuli may modify a sleep state or behavior associated with a sleep state, or may cause or hinder a transition from a waking state to a sleep state or from a sleep state to another sleep state. The neuromodulator may take electroencephalography measurements. Based on these measurements, the neuromodulator may detect, in real time, instantaneous amplitude and instantaneous phase of an endogenous brain signal. The neuromodulator may output stimulation that is, or that causes sensations which are, phase-locked with the endogenous brain signal. In the course of calculating instantaneous phase and amplitude, the neuromodulator may perform an endpoint-corrected Hilbert transform. The stimuli may comprise auditory, visual, electrical, magnetic, vibrotactile or haptic stimuli.

Systems and Methods for Ambulatory Generation of Nitric Oxide

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula. 1. A portable nitric oxide (NO) generation system comprising:a housing configured to be portable;a reactant gas flow path configured to provide a reactant gas to one or more plasma chambers;one or more electrodes located in the one or more plasma chambers configured to generate a product gas containing nitric oxide using a flow of the reactant gas through the one or more plasma chambers;a controller configured to regulate the amount of nitric oxide generated in the reactant gas; and{'sub': '2', 'one or more scrubber paths configured to remove NOfrom the product gas generated by the one or more plasma chambers;'}wherein the portable NO generation system can be integrated with a device selected from a group consisting of a ventilator, a defibrillator, a ventricular assist device (VAD), a Continuous Positive Airway Pressure (CPAP) machine, a Bilevel Positive Airway Pressure (BiPAP) machine, a non-invasive positive pressure ventilator (NIPPV), a nasal cannula application, a nebulizer, an extracorporeal membrane oxygenation (ECMO), a bypass system, an automated CPR system, an oxygen delivery system, an oxygen concentrator, an oxygen generation system, and an automated external defibrillator AED.2. The portable nitric ...

A device and a method for providing resuscitation or suspended state in cardiac arrest

Disclosed is a device for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a patient. The device includes an electrically controllable redistribution component attachable to the patient to provide redistribution of the cardiac output to increase supply to the brain and heart. The redistribution component, following a predefined reaction pattern based on an electrical signal, and computer means configured to: receive a patient data which identifies physiological and/or anatomical characteristics of the patent; and provide the electrical signal for the redistribution component based on the patient data or a standard response. The device may provide mechanisms to protect the aorta and the remaining anatomy of the patient from inadvertent damage caused by the disclosed device in any usage scenario of either correct intended usage or unintended usage. Also disclosed is a method for providing resuscitation or suspended state. 1. A device for providing resuscitation or suspended state through redistribution of cardiac output to increase supply to the brain and heart for a patient , the device comprisingan electrically or manually controllable redistribution component attachable to the patient and being configured to interact with the patient to provide redistribution of the cardiac output to increase supply to the brain and heart, the redistribution component following a predefined reaction pattern based on an electrical signal, and receive a patient data which identifies physiological and/or anatomical characteristics of the patient; and', 'provide the electrical signal for controlling the redistribution component and/or for presenting the physiological and/or anatomical characteristics for a user based on the patient data or a standard response., 'computer means configured to2. The device according to claim 1 , where the computer means comprises memory means having stored therein a ...

SELF-CONTAINED HEART PUMP

A heart pump includes a rotative impeller partly inserted into the systemic ventricle, this rotative impeller being equipped with a membrane sutured to the outer wall of the heart in such a way as to secure the rotative impeller to the wall of the heart, a housing arranged inside the systemic ventricle in such a way as to draw up then discharge blood, a motor connected to the housing and arranged partly outside the systemic ventricle in such a way as to facilitate maintenance; an integrated management unit in the epigastric region including a power supply and a rotative impeller control unit; and a wired link between the management unit and the rotative impeller. 1. A heart pump configured to be inserted partly into a systemic ventricle of a heart , through a wall of the heart , the heart pump comprising:a housing comprising at least one opening on its side wall in such a way as to allow for the drawing up of blood inside the systemic ventricle and, an upper opening for the discharge of blood through inside the systemic ventricle;an impeller inserted inside the housing;a motor connected to the housing at opposite side of the upper opening;a sealing and fixing membrane fastened to and around the motor;a management unit comprising a power supply, and an impeller control unit;a wired link between the management unit and the impeller; andan activity sensor configured to collect cardiac activity to synchronize an operation of the impeller with electrosystolic activity of the heart.2. The heart pump according to claim 1 , wherein the sealing and fixing membrane is circular thereby being configured to ensure a complete seal and secure the heart pump to the bottom part of the heart near an apex of the heart.3. The heart pump according to claim 1 , wherein the impeller is a rotary impeller and comprises a propeller shaft disposed in the housing.4. The heart pump according to claim 1 , wherein the impeller is a rotary impeller and comprises an Archimedes screw or worm shaft ...

SYSTEMS AND METHODS FOR THE CONDITIONING OF CEREBROSPINAL FLUID

Systems and methods for treating biologic fluids are disclosed. Some disclosed embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject, heat CSF to a target temperature, cool CSF to a target temperature, apply light treatment to CSF, separate cells via their dielectric properties, apply spiral and/or centrifugal separation, introduce additives to target particles, and/or apply combinations thereof. The method may include the steps of withdrawing fluid comprising CSF, treating the fluid, and returning a portion of the treated fluid to the subject. During operation of the system, various parameters may be modified, such as flow rate. 1. A method for treating cerebrospinal fluid (CSF) of a human or animal subject , the method comprising the steps of:withdrawing a volume of fluid comprising CSF from a CSF-containing space of the subject at a first flow rate;treating the volume of fluid;measuring a characteristic of the volume of fluid using a sensor;returning at least a portion of the treated volume of fluid to the CSF-containing space of the subject at a second flow rate; andupdating a parameter of a set of operation parameters based on the measured characteristic responsive to determining that the measured characteristic passes a predetermined threshold.2. The method of claim 1 , wherein treating the volume of fluid comprises filtering the volume of fluid into permeate and retentate using a tangential flow filter.3. The method of claim 2 , further comprising increasing a rate at which the volume of fluid passes through the tangential flow filter by diverting a portion of the permeate or retentate back through the tangential flow filter.4. The method of claim 2 , further comprising inhibiting microorganism growth on the tangential flow filter by heating of the filter.5. The method of claim 1 , wherein treating the volume of fluid comprises separating a first portion of the volume of fluid from a second portion of the volume of fluid ...

SYSTEMS AND METHODS FOR THE CONDITIONING OF CEREBROSPINAL FLUID

Systems and methods for treating biologic fluids are disclosed. Some disclosed embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject, heat CSF to a target temperature, cool CSF to a target temperature, apply light treatment to CSF, separate cells via their dielectric properties, apply spiral and/or centrifugal separation, introduce additives to target particles, and/or apply combinations thereof. The method may include the steps of withdrawing fluid comprising CSF, treating the fluid, and returning a portion of the treated fluid to the subject. During operation of the system, various parameters may be modified, such as flow rate. 1. A system for treating cerebrospinal fluid of a human or animal subject , the system comprising:a catheter assembly including a first fluid pathway and a second fluid pathway;a tangential flow filter coupled to the catheter assembly, the tangential flow filter being in fluid communication with the first fluid pathway and being in fluid communication with the second fluid pathway;a pump configured to withdraw a volume of cerebrospinal fluid from the human or animal subject and transfer the volume of cerebrospinal fluid to the tangential flow filter along the first fluid pathway;wherein the tangential flow filter is configured to filter the volume of cerebrospinal fluid into a permeate and a retentate;wherein the pump is configured to return at least a portion of the permeate to the human or animal subject along the second fluid pathway; anda processing unit configured to increase a rate at which the volume of cerebrospinal fluid passes through the tangential flow filter by diverting a diverted portion of the permeate or retentate back through the tangential flow filter.2. The system of claim 1 , further comprising a sensor disposed adjacent to the tangential flow filter.3. The system of claim 2 , wherein the sensor is configured to measure a characteristic of the volume of cerebrospinal fluid.4. The ...

SYSTEMS AND METHODS FOR DELIVERING CHEMICAL AND ELECTRICAL STIMULATION ACROSS ONE OR MORE NEURAL CIRCUITS

Systems, devices, and methods are provided for delivering chemical and electrical stimulation across one or more neural circuits. The systems, devices, and methods can also be used for sensing and recording specific neural activity. In certain embodiments, a system includes first and second fluid reservoirs, a manifold, and a delivery tube. The manifold may include first and second chambers therein. The first chamber may be in fluid communication with the first reservoir, and the second chamber may be in fluid communication with the second reservoir. The delivery tube may include a first conduit in fluid communication with the first chamber, a second conduit in fluid communication with the second chamber, and a third conduit configured to house an electrode therein. In this manner, a distal tip of the delivery tube is configured to be positionable adjacent to the one or more neural circuits for providing chemical and electrical stimulation thereto. 1. An injectrode , comprising:a manifold comprising at least one chamber therein, wherein the at least one chamber comprises a plurality of chambers; and at least one conduit configured to be in fluid communication with the at least one chamber, wherein the at least one conduit comprises a plurality of conduits each in fluid communication with a respective chamber of the plurality of chambers; and', 'at least one electrode conduit configured to house an electrode therein,, 'a delivery tube comprisingwherein a distal tip of the delivery tube is configured to be positioned adjacent to the one or more neural circuits for providing chemical stimulation, electrical stimulation, sensing of neural activity, or a combination thereof, andwherein the at least one conduit has a length of at least about 5 cm and a volume hold up of less than about 10 μL.2. The injectrode of claim 1 , wherein the plurality chambers are at least partially separated by one or more septum partitions.3. The injectrode of claim 1 , wherein the at least one ...

Decongestive therapy titration for heart failure patients using implantable sensor

Assessing decongestive therapy delivered to a heart failure patient involves use of an implantable sensor configured to sense a physiologic parameter indicative of the patient's diuresis status and a processor coupled to the implantable sensor. The sensor may comprise a thoracic fluid sensor, a heart sounds sensor, a cardiac chamber or arterial pressure sensor, a respiration sensor, or a blood chemistry sensor, for example. The processor is configured to determine if a target level of patient diuresis has been achieved based on a relationship between the sensed physiologic parameter and a threshold developed for the patient, and to produce an output in response to determining that the target level of patient diuresis has been achieved. The processor may be disposed in an implantable housing, in a patient-external housing, or in a network server system.

TRANSVASCULAR DIAPHRAGM PACING SYSTEMS AND METHODS OF USE

Transvascular diaphragm pacing systems (TDPS) and methods are disclosed for providing respiratory therapy to a patient. The TDPS can provide rapid insertion and deployment of endovascular pacing electrodes in critically ill patients who require intubation and invasive PPMV in order to support the physiological requirements of the human ventilatory system. The systems and methods make best use of the contractile properties of the diaphragm muscle and prevent muscle disuse and muscle atrophy. This can be carried out by engaging the phrenic nerves using patterned functional electrical stimulation applied to endovascular electrodes that are temporarily and reversibly inserted in central veins of the patient, such as the left subclavian vein and the superior vena cava. The TDPS can be designed to seamlessly interface with any commercially available positive-pressure ventilatory assistance/support equipment such as is commonly in use in hospital intensive care units (ICU) for treating critically ill patients with breathing insufficiencies, pain, trauma, sepsis or neurological diseases or deficits. 155-. (canceled)56. A method for stimulating , the method comprising:placing a sensor under the skin of a patient;measuring, via the sensor, a thoracic pressure;calculating an electrical stimulation signal based on the thoracic pressure; anddelivering the calculated electrical stimulation, via one or more electrodes, to a nerve.57. The method of claim 56 , wherein the sensor is connected to a lead within a body claim 56 , the body being configured to be inserted into the patient.58. The method of claim 56 , wherein delivering the calculated electrical stimulation to the nerve at least partially activates a respiratory muscle.59. The method of claim 56 , further comprising claim 56 , after delivering the calculated electrical stimulation:measuring a parameter of the heart;calculating a second electrical stimulation signal, based on the parameter; anddelivering the calculated ...

ELECTRICALLY-INDUCED FLUID FILLED BALLOON CATHETER

The present disclosure relates generally to the use of medical devices for the treatment of vascular conditions. In particular, the present disclosure provides devices and methods for using electrically-induced pressure waves to disrupt vascular blockages. The present disclosure not only provides devices and methods for using electrically-induced pressure waves to disrupt vascular blockages, but the present disclosure also provides devices and method for assisting the guidewire in penetrating an occlusion, devices and method for using a sealable valve in the tip of the balloon catheter to reduce the overall size and diameter of the balloon catheter, thereby allowing the balloon catheter to penetrate smaller size blood vessels and devices. Given the persistence of coronary artery disease (CAD) and peripheral artery disease (PAD), there remains a need for improved therapeutic methods designed not only to reduce vascular blockages in the short term, but also to prevent future complications such as restenosis. 117.-. (canceled)18. A catheter comprising: 'at least one electrode assembly adjacent to the guidewire lumen, wherein the at least one electrode assembly is coupled to an electrical generator and produces an electrical pulse;', 'a sheath having a guidewire lumen, an inflation lumen, a proximal end and a distal end;'} one or more liquid medium ports disposed within the sheath and within the balloon assembly; and', 'a pressure-wave reflective element disposed adjacent the balloon assembly, wherein the pressure-wave reflective element attenuates the pressure wave passing therethrough upon creation of the pressure wave within the balloon assembly by the reaction between the electrical pulse produced by the electrode assembly and a liquid medium introduced into the balloon assembly via the one or more liquid medium ports., 'a balloon assembly circumferentially arranged around a portion of the sheath and around at least one electrode assembly;'}19. The catheter of claim ...

Ventilation Monitoring

A ventilation monitoring system for assisting in proper placement of an endotracheal tube in a subject includes: a capnography sensor configured to be placed in fluid communication with the endotracheal tube and to provide information representative of the subject's breath; and a processor in communication with the capnography sensor. The processor is configured to provide an indication of proper endotracheal tube placement when (1) a first indication of the subject's breath and a positive result of a first auscultation are identified within a first predetermined time period, and (2) a second indication of the subject's breath and a positive result of a second auscultation are identified within a second predetermined time period. The first auscultation includes auscultation of a subject's left lung, right lung, left axillary region, right axillary region, or abdomen. The second auscultation includes auscultation of another region of the subject different from the first auscultation.

Method and Device for Enhanced Blood Flow

A non-invasive method and device for promoting a localized change in a flow of blood through a blood vessel in a limb segment of a body by a series of electrically stimulated contractions of muscle tissue in the limb segment, the method including the steps of: (a) providing a device including: (i) first, second and third electrodes, each adapted to operatively contact the limb segment; (ii) a signal generator, operatively connected to the electrodes, adapted to produce a series of electrical impulses to the limb segment via the electrodes, and (iii) a control unit adapted to control the signal generator to produce the series of electrical impulses; (b) positioning the electrodes on the limb segment, wherein the first electrode is positioned on a lower end of the lower leg, the second electrode is positioned on the lower leg, and the third electrode is positioned on an upper end of the lower leg, whereby the first and third electrodes are disposed on opposite ends of the lower leg, and the second electrode and one of the first and third electrodes are disposed on a same end of the lower leg; (c) effecting a sequence of muscular contractions of the lower leg, by operations including: (i) applying a first electrical impulse between the electrodes on the same end of the lower leg to induce a first muscular contraction of a first portion of the tissue; and (ii) applying at least a second electrical impulse between the first and third electrodes to induce a longitudinal muscular contraction of a second portion of the muscular tissue; and (d) repeating operations (i) and (ii), to repeatedly induce the contractions, to effect the increased flow of blood. 1. A non-invasive method for promoting a localized increase in a flow of blood through a blood vessel in a limb segment on a lower leg of a body of a subject , by a series of electrically stimulated contractions of muscle tissue in the limb segment , the method comprising the steps of: (i) a plurality of electrodes ...

PLASMA TREATMENT APPARATUS

Disclosed is a plasma treatment apparatus that includes a cover attached to a body part, a plasma generation unit that generates plasma and provides the plasma to the cover, a gas supply unit that supplies a source gas for generating the plasma to the plasma generation unit, and an exhaust unit that exhausts an exhaust gas from the cover. 1. A plasma treatment apparatus comprising:a cover attached to a body part;a plasma generation unit configured to generate plasma and provide the plasma to the cover;a gas supply unit configured to supply a source gas for generating the plasma to the plasma generation unit; andan exhaust unit configured to exhaust an exhaust gas from the cover.25-. (canceled)6. The plasma treatment apparatus of claim 1 , wherein the plasma generation unit is separated from the cover and provides the plasma to the cover through a tube that connects the plasma generation unit and the cover.7. The plasma treatment apparatus of claim 1 , wherein the plasma generation unit is installed on the cover and provides the plasma into a space between the cover and the body part.8. The plasma treatment apparatus of claim 7 , wherein the plasma generation unit includes opposite electrodes disposed to face each other.9. (canceled)10. The plasma treatment apparatus of claim 8 , wherein the plasma generation unit further includes an ozone absorption unit configured to absorb ozone between the opposite electrodes and the space between the cover and the body part.11. (canceled)12. The plasma treatment apparatus of claim 8 , wherein the plasma generation unit further includes a medicine supply unit configured to supply a medicine between the opposite electrodes and the space between the cover and the body part.13. (canceled)14. The plasma treatment apparatus of claim 1 , wherein a medicine is applied to at least part of one surface of the cover that faces the body part.15. The plasma treatment apparatus of claim 1 , wherein the plasma generation unit is integrated with ...

PORTABLE APPARATUS FOR DECONTAMINATION OF A BREAST

A portable device for the decontamination of a breast. The aim of the device is to reduce the risk of mastitis, even when the patient has a medicament incompatibility. For this purpose, the invention includes a decontamination unit which decontaminates the breast at least by means of a physical method. 1. Portable apparatus for decontamination of a breast comprising a decontamination unit which decontaminates said breast at least by way of a physical method.2. Apparatus according to claim 1 , wherein said decontamination unit comprises at least one of: a light source claim 1 , an ultrasonic source claim 1 , an ozonization source claim 1 , or a plasma source.3. Apparatus according to claim 2 , including a bell-like structure configured to be slipped over said breast and at least partially enclose said breast.4. Apparatus according to claim 3 , wherein said bell-like structure is adapted such that said breast is exposed thereto in true contour and the bell-like structure forms a recess in a region of a nipple of said breast on an inner side of the bell-like structure.5. Apparatus according to claim 4 , wherein said bell-like structure is formed such that it takes shape instantaneously only when donned onto said breast and returns to its initial state when removed from said breast.6. Apparatus according to claim 3 , wherein said decontamination unit comprises a housing in which one or more excitation radiation sources are provided claim 3 , where said housing is a separate element which is detachably mountable on said apparatus.7. Apparatus according to claim 6 , wherein said housing can be secured by being snapped onto said apparatus for decontamination of said breast at a section of a widened region which can be slipped over said breast and/or at a section of a cylindrical tube projecting from a side of said widened region facing away from said breast.8. Apparatus according to claim 6 , wherein electronics for operating said decontamination unit are connected only on ...

BIO-ELECTROCEUTICAL DEVICE USING CELL CLUSTER

A bio-electroceutical device includes: a cell reservoir configured to accommodate a cell cluster comprising an organoid fused with a biomaterial; and a cell controller configured to control, using an electrical signal, a secretion of an active component by the organoid in the cell cluster. 1. A bio-electroceutical device comprising:a cell reservoir configured to accommodate a cell cluster comprising an organoid fused with a biomaterial; anda cell controller configured to control, using an electrical signal, a secretion of an active component by the organoid in the cell cluster.2. The device of claim 1 , wherein the cell cluster is accommodated in the cell reservoir claim 1 , and the cell cluster comprises a hydrogel and a beta cell organoid disposed in the hydrogel.3. The device of claim 1 , further comprising:an electrochemical sensor configured to sense a target molecule,wherein, for the control of the secretion, the cell controller is configured to adjust an active component generation rate of the organoid in the cell cluster based on a result of the sensing of the target molecule.4. The device of claim 3 , wherein claim 3 , to sense the target molecule claim 3 , the electrochemical sensor is configured to sense another electrical signal generated by a reaction between the target molecule and an enzyme.5. The device of claim 3 , wherein claim 3 , for the control of the secretion claim 3 , the cell controller is configured to perform either one or both of:applying an electrical stimulation that facilitates the secretion of the active component by the organoid in the cell cluster; andinterrupting the electrical stimulation based on a concentration of the sensed target molecule.6. The device of claim 5 , wherein the interrupt of the electrical stimulation comprises either one or both of reduction of a level of the electrical stimulation and termination of the application of the electrical stimulation.7. The device of claim 3 , wherein claim 3 , for the control of ...

Nonjacketing side-entry connectors and prosthetic disorder response systems

Provided is a connector suitable for securely infixing a catheter, electrode, hollow needle, probe, or other styliform device with its tip stabilized within a nontubular anatomical structure. Secure junctions between fluid lines and/or electrodes and tissue are essential for automatic controls and permanent nephrostomies and suprapubic cystostomies, for example, using synthetic materials. These can be made self-contained and fully implanted to treat one chronic condition, or represent but one module controlled as an axis or channel of control in an adaptive ambulatory hierarchical prosthetic disorder response system used to automatically coordinate the treatment of chronic comorbid disease. Such applications require prosthesis-to-native tissue junctions which are secure, immobile, unsusceptible to leaks or microbial intrusion, and require little if any maintenance. Connection for securely and least disruptively merging catheteric and native lumina is described in nonprovisional application Ser. No. 14/121,365, entitled Ductus Side-entry Jackets and Prosthetic Disorder Response Systems, filed on 25 Aug. 2014. 1. A tissue connector for apposition against bodily tissue comprising a platform cushioned beneath , said platform having means for securely and rigidly engaging said tissue thereby to fasten to said tissue therapeutic and/or diagnostic devices in working relation to said tissue.2. A tissue connector according to claim 1 , wherein said means for securely and rigidly engaging said tissue comprises a plurality of rounded rotatable tissue-undercutting and anchoring needles and said therapeutic or diagnostic devices are interchangeably mounted to said platform claim 1 , said devices selected from the group comprised of fluid delivery lines claim 1 , electrical wires claim 1 , an electromagnet claim 1 , an aspiration line claim 1 , an electrode claim 1 , a cabled device such as an endoscope claim 1 , excimer laser claim 1 , alone or in combination with any of the ...

Wireless Ventilator Reporting

Systems and methods regarding ventilation of a patient, such as a victim at the scene of an emergency are described herein. 156-. (canceled)57. A medical system , comprising:an airflow sensor in an airflow path, wherein the airflow path is positioned to sense a presence of ventilation airflow and measure gas flow rates in the airflow path of a conscious patient experiencing dyspnea;a pressure sensor in the airflow path positioned to sense gas pressure in the airflow path of the conscious patient experiencing dyspnea;a processor arranged to receive data generated by the airflow sensor and the pressure sensor and determine one or more ventilation quality parameters requiring gas flow volume for their calculation, the one or more ventilation quality parameters including spirometric information, comprising circuitry configured for delivery of electromagnetic stimulation to the patient; anda feedback unit configured to provide feedback to a rescuer based on the one or more ventilation quality parameters.58. The system of claim 57 , wherein the feedback unit is configured to display the spirometric information as simultaneous display of flow rate and volume.59. The system of claim 57 , wherein the feedback unit is configured to display the spirometric information in the form of a graphical plot.60. The system of claim 57 , wherein the feedback unit is configured to display the spirometric information in the form of side-by-side numerics.61. The system of claim 57 , wherein the spirometric information includes spirometric information for one or more of: oxygen claim 57 , carbon dioxide claim 57 , overall gas volume claim 57 , and ventilation rate.62. The system of claim 57 , wherein the feedback unit is configured to display a single value that provides a measure of the squareness of a spirometry curve based on the spirometric information.6364-. (canceled)65. The system of claim 57 , wherein the processor is arranged to compute breathing pressure during the patient's ...

MULTI-MODAL PAIN MANAGEMENT DEVICE

A mobile pain management device for managing pain of a patient, the device includes a nerve block engageable with a first nerve of the patient and an electrical stimulation device engageable with a second nerve of the patient. The device includes an analgesic dispensing system having analgesic solution stored therein, the analgesic dispensing system connected to the nerve block such that when the nerve block is activated, the dispensing system provides at least a portion of the analgesic solution to the nerve block. The device includes a control module, in response to executable instructions, providing pain relieve the patient through engagement of the nerve block and the electrical stimulation. And the device includes a sensor detecting feedback from the patient such that the control module modifies the providing of pain relief to the patient based on the feedback. 1. A mobile pain management device for managing pain of a patient , the device comprising:a peripherical continuous nerve block engageable with a first nerve of the patient; a first vial containing analgesic liquid;', 'a second vial containing dilution liquid; and', 'a regulator controlling a first flow rate of analgesic liquid and second flow rate of the dilution liquid;, 'an analgesic dispensing system having analgesic solution stored therein, the analgesic dispensing system connected to the peripheral continuous nerve block, the analgesic dispensing system includinga plurality of sensors sensor associated with the patient, the sensors detecting feedback from the patient;a communication module in wireless communication with a network-based external system including transmission of at least a portion of the feedback from the patient detected by the sensors; anda control module, in response to the wireless communication with the network-based external system, controlling the analgesic dispensing system to provide pain relieve to the patient via the peripheral continuous nerve block in response to at ...

COMBINATION THERAPY INCLUDING PERIPHERAL NERVE FIELD STIMULATION

Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies. 1delivering peripheral nerve field stimulation to a region of a body of the patient in which a patient experiences pain via at least one electrode implanted in the region; anddelivering at least one other therapy that treats pain to the patient in combination with the peripheral nerve field stimulation.. A method for treating pain of a patient comprising: This application is a continuation of U.S. application Ser. No. 14/109,049, filed Dec. 17, 2013, which is a continuation of U.S. application Ser. No. 11/450,133, filed Jun. 9, 2006, now U.S. Pat. No. 8,620,435, which claims the benefit of U.S. Provisional Application No. 60/689,203, filed Jun. 9, 2005. U.S. application Ser. No. 11/450,133 is a continuation-in-part of each of U.S. application Ser. No. 11/374,852, filed on Mar. 14, 2006, now U.S. Pat. No. 7,813,803, Ser. No. 11/375,492, filed on Mar. 14, 2006, now U.S. Pat. No. 7,890,166, and Ser. No. 11/374,793, filed on Mar. 14, 2006, now U.S. Pat. No. 8,244,360, each of which claims the benefit of U.S. Provisional Application Nos. 60/700,627, filed on Jul. 19, 2005, and 60/761,823, filed on Jan. 25, 2006. The entire content of ...

ENHANCING LEFT VENTRICULAR RELAXATION THROUGH NEUROMODULATION

Neuromodulation is used to enhance left ventricular relaxation. An exemplary neuromodulation system includes a therapy element positionable in proximity to at least one nerve fiber, and a stimulator configured to energize the therapy element to delivery therapy to the at least one nerve fiber such that left ventricular relaxation and left ventricular contractility are contemporaneously enhanced. 1. A method of treating a patient having a left ventricular contractility (LVC) and a left ventricular relaxation (LVR) , comprising:delivering neuromodulation therapy to contemporaneously enhance LVC and LVR such that the ratio of the enhancement of LVC to the enhancement of LVR is within a predetermined range.2. The method of claim 1 , wherein the neuromodulation therapy includes:using at least one therapy element to neuromodulate at least one parasympathetic nerve fiber to increase LVR and to neuromodulate at least one sympathetic nerve fiber to increase LVC.3. The method of claim 1 , wherein the neuromodulation therapy is delivered to contemporaneously enhance LVC and LVR such that the ratio of the percentage increase of LVC to the percentage increase of LVR is within a predetermined range.4. The method of claim 3 , wherein the predetermined range is 0.5-1.5.5. The method of claim 3 , wherein the predetermined range is 0.8-1.2.6. The method of claim 3 , wherein the predetermined range is approximately 1.0.7. The method of claim 1 , wherein the step of delivering neuromodulation therapy includes positioning at least one therapy element in an intravascular location and neuromodulating an extravascular nerve fiber using the therapy element.8. The method of claim 7 , wherein the intravascular location is selected from the group of blood vessels consisting of the superior vena cava claim 7 , left brachiocephalic vein and right brachiocephalic vein.9. The method of claim 7 , wherein the intravascular location is selected from the group of blood vessels consisting of the ...

ENHANCING LEFT VENTRICULAR RELAXATION THROUGH NEUROMODULATION

Neuromodulation is used to enhance left ventricular relaxation. An exemplary neuromodulation system includes a therapy element positionable in proximity to at least one nerve fiber, and a stimulator configured to energize the therapy element to delivery therapy to the at least one nerve fiber such that left ventricular relaxation and left ventricular contractility are contemporaneously enhanced. 123-. (canceled)24. A method of treating a patient having a left ventricular contractility (LVC) and a left ventricular relaxation (LVR) , comprising:using a mechanical circulatory support device to increase cardiac output or aid in unloading the heart; andwhile using the mechanical circulatory support device, delivering neuromodulation therapy to contemporaneously enhance LVC and LVR.25. The method of claim 24 , wherein the neuromodulation therapy includes:using at least one therapy element to neuromodulate at least one parasympathetic nerve fiber to increase LVR and to neuromodulate at least one sympathetic nerve fiber to increase LVC.26. The method of claim 24 , wherein the neuromodulation therapy is delivered to contemporaneously enhance LVC and LVR such that the ratio of the percentage increase of LVC to the percentage increase of LVR is within a predetermined range.27. The method of claim 26 , wherein the predetermined range is 0.5-1.5.28. The method of claim 26 , wherein the predetermined range is 0.8-1.2.29. The method of claim 26 , wherein the predetermined range is approximately 1.0.30. The method of claim 24 , wherein the step of delivering neuromodulation therapy includes positioning at least one therapy element in an intravascular location and neuromodulating an extravascular nerve fiber using the therapy element.31. The method of claim 30 , wherein the intravascular location is selected from the group of blood vessels consisting of the superior vena cava claim 30 , left brachiocephalic vein and right brachiocephalic vein.32. The method of claim 30 , wherein the ...

Portable apparatus for decontamination of a breast

A portable device for the decontamination of a breast. The aim of the device is to reduce the risk of mastitis, even when the patient has a medicament incompatibility. For this purpose, the invention includes a decontamination unit which decontaminates the breast at least by means of a physical method.

SYNCHRONIZING MECHANICAL IN-EXSUFFLATION AND DIAPHRAGMATIC PACING

Systems and methods for synchronizing machine-induced inexsufflation with diaphragmatic pacing of a subject, e.g. through a diaphragm pacer, use the detected onset of an inhalation and/or exhalation of a subject. The detection is based on output signals generated by one or more sensors. 1. A system for synchronizing machine-induced inexsufflation with a diaphragmatic pacing of a subject , the system comprising;a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of the subject; i) one or more gas parameters of a flow of breathable gas being breathed by the subject and/or', 'ii) one or more respiratory parameters of the subject; and, 'one or more sensors configured to generate one or more output signals conveying information related to one or both of'} a configuration module configured to obtain one or more configurable operational settings of the diaphragmatic pacing of the subject;', 'a detection module configured to detect onsets of inhalations of the subject such that, for a first respiratory cycle, the detection module detects an onset of a first inhalation of the subject based on the one or more output signals, wherein the first inhalation is included in the first respiratory cycle;', 'a target module configured to determine a target parameter for machine-induced inexsufflation during respiratory cycles such that, responsive to detection of the onset of the first inhalation, the target module determines the target parameter for machine-induced inexsufflation during a second respiratory cycle such that the machine-induced inexsufflation occurs in synchrony with the diaphragmatic pacing of the subject, wherein the second respiratory cycle is subsequent to the first respiratory cycle, and wherein the target parameter corresponds to an onset of inhalation during the second respiratory cycle or an onset of exhalation during the second respiratory cycle; and', 'a control module configured to control the pressure ...

IMPLANTABLE HYBRID LEAD AND METHOD OF MANUFACTURING THE SAME

In an implantable hybrid lead and a method of manufacturing the implantable hybrid lead, the implantable hybrid lead includes a conduit, a line electrode and a plurality of electrode terminals. The conduit has a fine channel through which a medicine is injected. The line electrode is inserted to and is combined with an outside of the conduit, and applies electrical simulation to a selected portion of a living body. A plurality of electrode terminals is disposed at an end of the conduit by a predetermined distance. 1. An implantable hybrid lead comprising:a conduit having a fine channel through which a medicine is injected;a line electrode inserted to and combined with an outside of the conduit, and applying electrical simulation to a selected portion of a living body; anda plurality of electrode terminals disposed at an end of the conduit by a predetermined distance.2. The implantable hybrid lead of claim 1 , wherein the line electrode is a thin film electrode or thin film multi electrodes array.3. The implantable hybrid lead of claim 1 , wherein the line electrode is coiled around an outer surface of the conduit to be connected with the conduit claim 1 , by a predetermined distance.4. A method of manufacturing an implantable hybrid lead claim 1 , the method comprising:manufacturing a thin film electrode by MEMS;manufacturing a conduit using a liquid biocompatible polymer, the conduit having a fine channel through which a medicine is injected; andinserting and combining the thin film electrode with an outside of the conduit to be packaged.5. A method of manufacturing an implantable hybrid lead claim 1 , the method comprising:manufacturing thin film multi electrodes array by MEMS;manufacturing a conduit using a liquid biocompatible polymer, the conduit having a fine channel through which a medicine is injected; andinserting and combining the thin film multi electrodes array with an outside of the conduit to be packaged.6. The method of one of and claim 1 , the method ...

CONTINUOUS ANESTHESIA NERVE CONDUCTION APPARATUS, SYSTEM AND METHOD THEREOF

The invention generally relates to a continuous anesthesia nerve conduction apparatus and method thereof, and more particularly to a method and system for use in administering a continuous flow or intermittent bolus of anesthetic agent to facilitate a continuous or prolonged nerve block. In one embodiment, the apparatus includes a sheath having a proximal end, a distal end and at least one lumen extending from the proximal end to the distal end. The sheath also includes an embedded conductive element for transmitting an electrical signal from a proximal portion of the sheath to a distal portion of the sheath. A cannula is arranged in the at least one lumen of the sheath and has a distal end protruding from a distal portion of the sheath. The cannula is electrically coupled to at least a portion of the embedded conductive element and is configured to provide nerve stimulation. 1194.-. (canceled)195. An anesthetic drug delivery system adapted for administering a continuous flow or intermittent bolus of anesthetic agent to facilitate a continuous or prolonged nerve block , the system comprising:an over the needle catheter comprising a proximal end, a distal end, a lumen extending from the proximal end to the distal end, one or more lateral ports arranged at a location proximal to the distal end of the over the needle catheter, a preformed region arranged at a location proximal to the distal end of the over the needle catheter, and a hub integral with the proximal end of the over the needle catheter; anda cannula comprising a proximal end, a distal end, a lumen extending from the proximal end of the cannula to the distal end of the cannula, and a hub integral with the cannula,wherein the preformed region of the over the needle catheter is configured to move at least a portion of the over the needle catheter from a first position to a second position upon removal of the cannula in order to form a curved portion of the over the needle catheter,wherein the cannula is ...

CONTINUOUS ANESTHESIA NERVE CONDUCTION APPARATUS, SYSTEM AND METHOD THEREOF

The invention generally relates to a continuous anesthesia nerve conduction apparatus and method thereof, and more particularly to a method and system for use in administering a continuous flow or intermittent bolus of anesthetic agent to facilitate a continuous or prolonged nerve block. In one embodiment, the apparatus includes a sheath having a proximal end, a distal end and at least one lumen extending from the proximal end to the distal end. The sheath also includes an embedded conductive element for transmitting an electrical signal from a proximal portion of the sheath to a distal portion of the sheath. A cannula is arranged in the at least one lumen of the sheath and has a distal end protruding from a distal portion of the sheath. The cannula is electrically coupled to at least a portion of the embedded conductive element and is configured to provide nerve stimulation. 1194-. (canceled)195. An anesthetic drug delivery system adapted for administering a continuous flow or intermittent bolus of anesthetic agent to facilitate a continuous or prolonged nerve block , the system comprising:an over the needle catheter comprising a proximal end, a distal end, a lumen extending from the proximal end to the distal end, the over the needle catheter comprises a first outside diameter at a proximal end portion of the over the needle catheter and a second outside diameter at a distal end portion of the over the needle catheter, the first outside diameter being greater than the second outside diameter, and a hub integral with the proximal end of the over the needle catheter; anda cannula comprising a proximal end, a distal end, a lumen extending from the proximal end of the cannula to the distal end of the cannula, and a hub integral with the cannula,wherein the cannula is adapted to be inserted into the lumen of the over the needle catheter such that a distal end portion of the cannula extends past the distal end of the over the needle catheter, andwherein the over the ...

Systems and Methods for Ambulatory Generation of Nitric Oxide

Systems and methods are provided for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula. 1. A portable nitric oxide (NO) generation system comprising:a housing configured to be portable;a reactant gas flow path located in the housing, the reactant gas flow path configured to provide a reactant gas to one or more plasma chambers;one or more electrodes located in the one or more plasma chambers configured to generate a product gas containing nitric oxide using a flow of the reactant gas through the one or more plasma chambers;a controller configured to regulate the amount of nitric oxide generated in the reactant gas by controlling a shape of an AC waveform; and{'sub': '2', 'one or more scrubber paths configured to remove NOfrom the product gas generated by the one or more plasma chambers.'}2. The portable nitric oxide generation system of claim 1 , wherein the one or more scrubber paths includes one or more inlet filters and/or one or more exhaust filters.3. The portable nitric oxide generation system of claim 1 , further comprising one or more filters positioned to receive NO-enriched air from the one or more scrubber paths and configured to filter the NO-enriched air.4. The portable nitric oxide generation system of claim 1 , further comprising a connector to deliver the product gas to a patient ...

SMARTPHONE-CONTROLLED IMPLANTABLE NEURAL DEVICES FOR LONG-TERM WIRELESS DRUG DELIVERY AND LIGHT STIMULATION, AND OPERATING METHOD THEREOF

Various embodiments, which relate to an electronic device implanted in tissue of an animal and for delivering stimulation to the neural tissue and operating method thereof, may be configured to generate a control instruction based on a control signal wirelessly received from an external device, and based on the control instruction, to input stimulation through a neural probe formed with flexible material and led out to a predetermined location of the tissue. According to various embodiments, the stimulation includes chemical stimulation by a fluid type of drug, and the neural probe may be formed to flow drug, and may include at least one fluid tube for inputting the chemical stimulation by being opened at one end of the neural probe. 1. An electronic device implanted in neural tissue of an animal and for delivering stimulation to the tissue , comprising:a probe module including a neural probe formed with flexible material and led out to a predetermined location of the tissue, and configured to input the stimulation to the location through the neural probe; anda control module configured to be connected to the probe module and generate a control instruction for occurring the stimulation.2. The device of claim 1 ,wherein the stimulation comprises chemical stimulation by a fluid form of drug, andwherein the neural probe comprises at least one fluid tube for inputting the chemical stimulation to the location by being formed to flow the drug and opened at one end of the neural probe.3. The device of claim 1 ,wherein the stimulation comprises at least one among optical stimulation by light or electrical stimulation by an electrical signal, andwherein the probe module further comprises:at least one element for generating at least one of the optical stimulation or the electrical stimulation on the location based on the control instruction by being mounted on one end of the neural probe; andat least one connecting terminal prolonged along the neural probe and for ...

MICROSTRUCTURE SYSTEMS AND METHODS FOR PAIN TREATMENT

The present invention relates generally to devices comprising one or more microstructures that are used to relieve, treat or prevent pain. The devices are designed such that they are inserted into the superficial layers of the skin to achieve pain relief. The devices are designed such that the microstructures are able to grasp and secure to the skin. The devices may consist of microstructures in arrays that are attached to a backing to enable the devices to adhere to the skin. Also provided are wound closure systems that comprise one or more microstructure devices along with other components, such as protective covers and therapeutics. A variety of packaging specifications are disclosed, as is a dispenser apparatus configured to enable simple one-handed application of the devices. Methods described herein provide for treatment of pain. 1. A device to reduce or prevent pain or inflammation comprising one or more microstructures.2. The device according to that reduces pain or inflammation.3. The device according to that prevents pain or inflammation.4. The device according to claim 1 , wherein at least one microstructure is capable of penetrating into tissue.5. The device according to claim 1 , wherein the one or more microstructures are contained in an array of microstructures.6. The device according to claim 5 , wherein the array or microstructures is attached to a backing.7. The device according to claim 6 , wherein the backing is in the form of a roll bandage.8. The device according to claim 1 , wherein a height of the one or more microstructures is between 100 μm and 4 mm.9. The device according to claim 1 , wherein the one or more microstructures are selected from microneedles claim 1 , microblades claim 1 , microanchors claim 1 , microfishscale claim 1 , micropillars claim 1 , and microhairs.10. The device according to claim 1 , further comprising a spring structure incorporated into the one or more microstructures.11. The device according to claim 1 , wherein ...

COMBINATION THERAPY INCLUDING PERIPHERAL NERVE FIELD STIMULATION

Delivery of peripheral nerve field stimulation (PNFS) in combination with one or more other therapies is described. The other therapy delivered in combination with PNFS may be, for example, a different type of neurostimulation, such as spinal cord stimulation (SCS), or a drug. PNFS and the other therapy may be delivered simultaneously, in an alternating fashion, according to a schedule, and/or selectively, e.g., in response to a request received from a patient or clinician. A combination therapy that includes PNFS may be able to more completely address complex or multifocal pain than would be possible through delivery of either PNFS or other therapies alone. Further, the combination of PNFS with one or more other therapies may reduce the likelihood that neural accommodation will impair the perceived effectiveness PNFS or the other therapies. 1. (canceled)2. A method comprising:controlling, via a processor, delivery of a first therapy to a patient via a first implantable element according to a duty cycle such that the first therapy delivery is cycled on and off; andcontrolling, via the processor, delivery of a second therapy to the patient via a second implantable element in combination with delivery of the first therapy, wherein the second therapy is not delivered according to a duty cycle.3. The method of claim 2 , further comprising receiving user input requesting delivery of the second therapy claim 2 , wherein controlling delivery of the second therapy to the patient comprises controlling the delivery of the second therapy to the patient based upon receipt of the request from a user.4. The method of claim 2 , wherein the first implantable element is configured to deliver the first therapy to a first anatomical region and the second implantable element is configured to deliver the second therapy to a second anatomical region.5. The method of claim 4 , wherein the first anatomical region comprises one of a spinal cord or a limb of the patient claim 4 , and wherein ...

ENHANCING LEFT VENTRICULAR RELAXATION THROUGH NEUROMODULATION

Neuromodulation is used to enhance left ventricular relaxation and/or left ventricular contractility, during contemporaneous use of a mechanical circulatory support device to increase cardiac output or aid in unloading the heart. An exemplary neuromodulation system includes a therapy element positionable in proximity to at least one nerve fiber, and a stimulator configured to energize the therapy element to delivery therapy to the at least one nerve fiber such that left ventricular relaxation and left ventricular contractility are contemporaneously enhanced. 1. A method of treating a patient having a left ventricular contractility (LVC) and a left ventricular relaxation (LVR) , comprising:using a mechanical circulatory support device to increase cardiac output or aid in unloading the heart; andwhile using the mechanical circulatory support device, delivering neuromodulation therapy to contemporaneously enhance LVC and LVR.2. The method of claim 1 , wherein the neuromodulation therapy includes:using at least one therapy element to neuromodulate at least one parasympathetic nerve fiber to increase LVR and to neuromodulate at least one sympathetic nerve fiber to increase LVC.3. The method of claim 1 , wherein the neuromodulation therapy is delivered to contemporaneously enhance LVC and LVR such that the ratio of the percentage increase of LVC to the percentage increase of LVR is within a predetermined range.4. The method of claim 3 , wherein the predetermined range is 0.5-1.5.5. The method of claim 3 , wherein the predetermined range is 0.8-1.2.6. The method of claim 3 , wherein the predetermined range is approximately 1.0.7. The method of claim 1 , wherein the step of delivering neuromodulation therapy includes positioning at least one therapy element in an intravascular location and neuromodulating an extravascular nerve fiber using the therapy element.8. The method of claim 7 , wherein the intravascular location is selected from the group of blood vessels consisting ...

Systems and Methods for Ambulatory Generation of Nitric Oxide

The present disclosure relates to systems and methods for portable and compact nitric oxide (NO) generation that can be embedded into other therapeutic devices or used alone. In some embodiments, an ambulatory NO generation system can be comprised of a controller and disposable cartridge. The cartridge can contain filters and scavengers for preparing the gas used for NO generation and for scrubbing output gases prior to patient inhalation. The system can utilize an oxygen concentrator to increase nitric oxide production and compliment oxygen generator activity as an independent device. The system can also include a high voltage electrode assembly that is easily assembled and installed. Various nitric oxide delivery methods are provided, including the use of a nasal cannula. 1. A wearable nitric oxide generation system comprising:a housing configured to be wearable;a reactant gas flow path located in the housing, the reactant gas flow path configured to provide release of a pressurized reactant gas at specific flow rates to one or more plasma chambers;one or more electrodes located in the one or more plasma chambers configured to generate a product gas containing nitric oxide using a flow of the reactant gas through the one or more plasma chambers;a controller configured to regulate the amount of nitric oxide generated in the reactant gas;{'sub': '2', 'a disposable cartridge including one or more scavenger paths configured to remove NOfrom the product gas generated by the one or more plasma chambers, and'}a connector to deliver the product gas to a patient delivery device;wherein the controller measures a resonant frequency of a high voltage circuit and controls a frequency and a duty cycle of an AC waveform to maximize excitation of the high voltage circuit andwherein the resonant frequency is determined throughout a service life of the system to accommodate changes in environmental conditions, system wear, and/or manufacturing variance.2. The wearable nitric oxide ...

MEDICAL DEVICE FOR GENERATING ULTRASONIC WAVES AND ELECTRICAL STIMULATION SIGNAL

A medical device can comprise: a piezoelectric element for generating ultrasonic waves; a transmission unit coming into contact with the piezoelectric element, and transmitting, to the skin, the ultrasonic waves and an electrical stimulation signal generated from the outside; and a guide having a ring shape having an inner surface and an outer surface, and coming into contact with one surface of the transmission unit in order to provide a functional material accommodation space. The functional material accommodation space can be defined by the inner surface of the guide and the one surface of the transmission unit. According to the present invention, a functional material accommodation space capable of maximizing the area in which a functional material and the skin make contact can be provided, and the configuration of a circuit for generating ultrasonic waves and the configuration of a circuit for generating an electrical stimulation signal can be simplified. 1. A medical device comprising:a piezoelectric element configured to generate an ultrasonic wave;a transmission unit configured to transmit the ultrasonic wave and an electrical stimulation signal generated from the outside to a skin, while contacting the piezoelectric element; anda guide having a ring shape having an inner side and an outer side and contacting one surface of the transmission unit in order to define a functional material accommodation space,wherein the functional material accommodation space is defined by the inner side of the guide and the one surface of the transmission unit.2. The medical device of claim 1 , wherein a functional material provided to the functional material accommodation space is injected into the skin by using the ultrasonic wave.3. The medical device of claim 1 , wherein the piezoelectric element generates the ultrasonic wave at an interval of a reference frequency claim 1 , andthe piezoelectric element generates the ultrasonic wave in an interval during which the ...

MASS TRANSPORT INSIDE MAMMALS

An apparatus, comprising, a cochlear implant electrode array, and an implantable drug reservoir, wherein the apparatus is configured such that the drug reservoir is in fluid communication with the electrode array, and the drug reservoir is at least substantially located in a middle ear space when the cochlear implant electrode array is fully implanted in a recipient. 1. An apparatus , comprising:a cochlear implant electrode array; andan implantable therapeutic substance reservoir, whereinthe apparatus is configured such that the therapeutic substance reservoir is in fluid communication with the electrode array, andthe therapeutic substance reservoir is at least substantially located in a middle ear space when the cochlear implant electrode array is fully implanted in a recipient.2. The apparatus of claim 1 , wherein:the reservoir is an elastomeric enclosure that expands upon the insertion of a liquid therapeutic substance therein, which expansion maintains the liquid therapeutic substance under pressure, and forces the therapeutic substance out of the reservoir and into the electrode array over time.3. The apparatus of claim 1 , wherein:the electrode array is configured such that the therapeutic substance elutes from the array upon entering the array into the cochlea.4. The apparatus of claim 1 , wherein:the apparatus is pumpless.5. The apparatus of claim 1 , wherein:the apparatus is configured to enable refilling of the reservoir without explanting the reservoir.6. The apparatus of claim 1 , further comprising:a valve, wherein the valve controls flow of the therapeutic substance from the reservoir into the electrode array.7. The apparatus of claim 1 , further comprising:a flow restrictor that restricts flow out of the reservoir into the electrode array beyond that which would be the case in the absence of the flow restrictor.89-. (canceled)10. An apparatus claim 1 , comprising:an implantable therapeutic substance reservoir; andan implantable electrode array ...

Medical Treatment Device and Method for Stimulating Neurons of a Patient to Suppress a Pathologically Synchronous Activity of the Neurons

The present invention relates to a medical treatment device for stimulating neurons of a patient. The device comprises a first non-invasive stimulating device for generating at least two different first stimuli to a patient's body, a second non-invasive stimulating device for generating at least two different second stimuli to the patient's body, and a control unit for selectively and intermittently actuating the stimulating devices. In a first operating mode, the control unit is configured to actuate the first stimulating device in a sequence of successive actuating periods such that a number n of first stimuli to be generated simultaneously during the actuating periods is variedly determined across the sequence and to actuate the second stimulating device so as to generate the second stimuli to be paired to the generation of at least a part of the first stimuli. In a second operating mode, the control unit is configured to actuate the second stimulating device so as to generate the second stimuli to be de-coupled from the generation of at least a part of the first stimuli. 1. Medical treatment device for stimulating neurons of a patient to suppress a pathologically synchronous activity of the neurons , the device comprises:a first non-invasive stimulating device for generating at least two different first stimuli to a patient's body,a second non-invasive stimulating device for generating at least two different second stimuli to the patient's body, anda control unit for selectively and intermittently actuating the first and the second stimulating device, wherein the control unit is configured to,in a first operating mode, actuate the first stimulating device in a sequence of successive actuating periods such that a number n of first stimuli to be generated simultaneously during the actuating periods is variedly determined across the sequence and to actuate the second stimulating device so as to generate the second stimuli to be paired to the generation of at least ...

Sealed two-way magnetic manifold

An irrigated medical device, including an inlet tube configured to receive an irrigation fluid from a pressurized fluid source, at least first and second outlet tubes configured to deliver the irrigation fluid to respective outlets of the device, a manifold containing a chamber coupled between the inlet tube and at least the first and second outlet tubes, and a ball including a magnetic material contained inside the chamber. The irrigated medical device also includes a magnetic field generator disposed outside the chamber and configured to generate a variable magnetic field within the chamber so as to move the ball between at least a first position in which the first outlet tube is blocked, a second position in which the second outlet tube is blocked, and a third position, in which neither of the outlet tubes is blocked.

Method and Device for Enhanced Blood Flow

A non-invasive method and device for promoting a localized change in a flow of blood through a blood vessel in a limb segment of a body by a series of electrically stimulated contractions of muscle tissue in the limb segment, the method including the steps of: (a) providing a device including: (i) first, second and third electrodes, each adapted to operatively contact the limb segment; (ii) a signal generator, operatively connected to the electrodes, adapted to produce a series of electrical impulses to the limb segment via the electrodes, and (iii) a control unit adapted to control the signal generator to produce the series of electrical impulses; (b) positioning the electrodes on the limb segment, wherein the first electrode is positioned on a lower end of the lower leg, the second electrode is positioned on the lower leg, and the third electrode is positioned on an upper end of the lower leg, whereby the first and third electrodes are disposed on opposite ends of the lower leg, and the second electrode and one of the first and third electrodes are disposed on a same end of the lower leg; (c) effecting a sequence of muscular contractions of the lower leg, by operations including: (i) applying a first electrical impulse between the electrodes on the same end of the lower leg to induce a first muscular contraction of a first portion of the tissue; and (ii) applying at least a second electrical impulse between the first and third electrodes to induce a longitudinal muscular contraction of a second portion of the muscular tissue; and (d) repeating operations (i) and (ii), to repeatedly induce the contractions, to effect the increased flow of blood. 1. A non-invasive method for promoting a localized increase in a flow of blood through a blood vessel in a limb segment on a lower leg of a body of a subject , by a series of electrically stimulated contractions of muscle tissue in the limb segment , the method comprising the steps of: (i) a plurality of electrodes ...

SYSTEMS AND METHODS FOR NEURAL DRUG DELIVERY AND MODULATION OF BRAIN ACTIVITY

A neural drug delivery system is disclosed. In an embodiment, the system includes two or more microtubes, each having a distal end, a proximal end, and elongate channel body extending therebetween; an electrode having a distal end, a proximal end, and elongate body extending therebetween; an elongate carrying template supporting the microtubes and the electrode in an aligned stack; and an annular needle having a distal end and a proximal end, and housing the carrying template, the microtubes, and the electrode. The system may include at least one pump fluidically connected to the proximal end(s) of one or more of the microtubes. The pump may be configured to deliver a fluid drug on demand through the elongate channel body and out of the distal end of the microtubes. 1. A drug delivery system , comprising:two or more discrete, annular microtubes, wherein each of the two or more microtubes comprises a distal end, a proximal end, and elongate channel body extending therebetween;an electrode comprising a distal end, a proximal end, and elongate body extending therebetween;an elongate carrying template supporting the two or more microtubes and the electrode in an aligned stack;an annular needle having distal end and a proximal end, an annulus of the needle housing the carrying template, the two or more microtubes, and the electrode; andat least one pump fluidically connected to the proximal end(s) of one or more of the two or more microtubes, wherein the at least one pump is configured to deliver a fluid drug on demand through the elongate channel body and out of the distal end of the one or more microtubes.2. The drug delivery system of claim 1 , wherein each of the microtubes has an outer diameter of about 30 microns and an inner diameter of about 20 microns.3. The drug delivery system of claim 1 , wherein the elongate carrying template comprises a microfabricated polyimide structure.4. The drug delivery system of claim 1 , wherein the annular needle comprises a ...

APPARATUS AND METHOD FOR IMPROVED ASSISTED VENTILATION

Devices and methods for allowing for improved assisted ventilation of a patient. The methods and devices provide a number of benefits over conventional approaches for assisted ventilation. For example, the methods and devices described herein permit blind insertion of a device that can allow ventilation regardless of whether the device is positioned within a trachea or an esophagus. In addition, the methods and device allow for timed delivery of ventilations based on a condition of a thoracic cavity to increase the amount and efficiency of blood flow during a resuscitation procedure. 1inserting a ventilation device within a respiratory opening of the individual and positioning a working end of the ventilation device within a body passageway of the individual, the ventilation device having a pressure sensor configured to detect pressure changes within the body passage;delivering a bolus of air into an airway the individual at a pre-determined rate;altering the pre-determined rate by delaying delivery of the bolus of air when the sensor detects a pressure change in the air within the body passage, where the pressure change within the body passage results from a chest compression.. A method artificially ventilating an individual, the method comprising: The present is a continuation of U.S. patent application Ser. No. 14/750,998 filed Jun. 25, 2015 (now U.S. Pat. No. 9,802,014 issued on Oct. 31, 2017), which is a continuation of U.S. patent application Ser. No. 14/666,244 filed Mar. 23, 2015 (now U.S. Pat. No. 9,757,530 issued on Sep. 12, 2017), which is a non-provisional application of U.S. Provisional Application 61/969,043 filed Mar. 21, 2014 and is a continuation-in-part of U.S. patent application Ser. No. 14/296,298 filed Jun. 4, 2014 (now U.S. Pat. No. 9,220,858 issued on Dec. 29, 2015), which is a continuation of U.S. patent application Ser. No. 13/659,699 filed Oct. 24, 2012 (now U.S. Pat. No. 8,776,796 issued on Jul. 15, 2014) which claims benefit to U.S. ...

Systems, devices and methods for neurostimulation having a modulation of packets

A method of neurostimulation may include delivering an electrical signal to a plurality of electrodes connected to a patient. The electrical signal may include a plurality of spaced-apart packets of electrical pulses. The method may include modulating at least one of a quantity of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, a width in time of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, an amplitude in voltage of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, a separation in time between adjacent ones of the plurality of electrical pulses within ones of the plurality of packets of electrical pulses, and a separation in time between adjacent ones of the plurality of packets of electrical pulses to modulate the electrical signal.

Method and Device for Enhanced Blood Flow

A non-invasive method and device for promoting a localized change in a flow of blood through a blood vessel in a limb segment of a body by a series of electrically stimulated contractions of muscle tissue in the limb segment, the method including the steps of: (a) providing a device including: (i) first, second and third electrodes, each adapted to operatively contact the limb segment; (ii) a signal generator, operatively connected to the electrodes, adapted to produce a series of electrical impulses to the limb segment via the electrodes, and (iii) a control unit adapted to control the signal generator to produce the series of electrical impulses; (b) positioning the electrodes on the limb segment, wherein the first electrode is positioned on a lower end of the lower leg, the second electrode is positioned on the lower leg, and the third electrode is positioned on an upper end of the lower leg, whereby the first and third electrodes are disposed on opposite ends of the lower leg, and the second electrode and one of the first and third electrodes are disposed on a same end of the lower leg; (c) effecting a sequence of muscular contractions of the lower leg, by operations including: (i) applying a first electrical impulse between the electrodes on the same end of the lower leg to induce a first muscular contraction of a first portion of the tissue; and (ii) applying at least a second electrical impulse between the first and third electrodes to induce a longitudinal muscular contraction of a second portion of the muscular tissue; and (d) repeating operations (i) and (ii), to repeatedly induce the contractions, to effect the increased flow of blood.

Continuous anesthesia nerve conduction apparatus, system and method thereof

The invention generally relates to a continuous anesthesia nerve conduction apparatus and method thereof, and more particularly to a method and system for use in administering a continuous flow or intermittent bolus of anesthetic agent to facilitate a continuous or prolonged nerve block. In one embodiment, the apparatus includes a sheath having a proximal end, a distal end and at least one lumen extending from the proximal end to the distal end. The sheath also includes an embedded conductive element for transmitting an electrical signal from a proximal portion of the sheath to a distal portion of the sheath. A cannula is arranged in the at least one lumen of the sheath and has a distal end protruding from a distal portion of the sheath. The cannula is electrically coupled to at least a portion of the embedded conductive element and is configured to provide nerve stimulation.

WOUND THERAPY DEVICE AND METHOD

A wound therapy device and method includes a skin contacting element, a reactor, and a reactor housing element. The skin contacting element is configured for covering an associated tissue site, the reactor for creating a pressure condition at the associated tissue site upon actuation thereof, and the reactor housing element for accommodating the reactor. The skin contacting element has a skin contacting side and an interface side, which is opposite the skin contacting side. The reactor housing element has a lower affixing side and an upper side, which is opposite the lower affixing side. 1. A method of assembling a wound therapy device , comprising:packaging a skin contacting element, a first seal and a first release layer as a first package component of the wound therapy device, wherein a first adhesive is disposed on a skin contacting side of the skin contacting element for adhering the skin contacting element around a tissue site, wherein the first seal is applied over the first adhesive and is configured to seal the skin contacting element around the tissue site, and the first release layer being removable to expose the first adhesive and the first seal provided on the skin contacting side of the skin contacting element; andpackaging a reactor housing element, a second seal and a reactor, which is an oxygen scavenger, as a second, separate, package component of the wound therapy device, wherein a second adhesive is disposed on a lower affixing side of the reactor housing element for adhering the reactor housing element to the skin contacting element, wherein the second seal being configured to promote sealing between the skin contacting element and the reactor housing element when the reactor housing element is adhered to the skin contacting element with the reactor disposed therebetween.2. The method of claim 1 , wherein the reactor housing element is a thin sheet-like membrane.3. The method of claim 1 , wherein packaging the reactor housing element claim 1 , ...

VENTILATION MACHINE AND METHOD OF VENTILATING A PATIENT

A ventilation machine is disclosed that includes a conduit interface configured to be connected to a respiratory system of a human or animal patient, an air flow generator configured to deliver air through the conduit interface into the respiratory system of the patient, a processing unit in communication with the air flow generator and configured to control the airflow generator to deliver air into the respiratory system of the patient according to a breathing scheme, and an induction device for activating a diaphragm of the patient. The induction device is in communication with the processing unit. The processing unit is configured to control the induction device to activate the diaphragm in coordination with the breathing scheme. 178-. (canceled)79. A ventilation machine , preferably being a single assembly , comprising:a conduit interface configured to be connected to a respiratory system of a human or animal patient;an air flow generator configured to deliver air through the conduit interface into the respiratory system of the patient;a processing unit in communication with the air flow generator and configured to control the airflow generator to deliver air into the respiratory system of the patient according to a breathing scheme; and the induction device is in communication with the processing unit, and', 'the processing unit is configured to control the induction device to activate the diaphragm in coordination with the breathing scheme., 'an induction device, preferably an electro-magnetic induction device, for activating a diaphragm of the patient, wherein'}80. The ventilation machine of claim 79 , wherein the processing unit comprises an input interface and the processing unit is configured such that the breathing scheme can be inputted via the input interface.81. The ventilation machine of claim 79 , wherein the breathing scheme comprises a time gap between start of operation of the induction device and start of operation of the air flow generator.82. ...

METHODS OF IMPROVING CRANIOFACIAL PAIN AND STROKE RECOVERY

Methods of improving craniofacial pain or stroke recovery via neurostimulation are provided. Methods include first screening the subject for neurostimulation based on the subject's responsiveness to a block of the sphenopalatine ganglion or branch thereof. 1. A method of improving craniofacial pain in a subject suffering therefrom comprising:applying an anesthetic to a first dorsonasal structure of the subject;determining if application of the anesthetic results in an improvement in craniofacial pain;identifying the subject as a candidate for neurostimulation upon a determination that application of the anesthetic results in an improvement in the craniofacial pain;placing a neurostimulator adjacent to a second dorsonasal structure upon an identification of the subject as a candidate for neurostimulation;activating the neurostimulator to deliver a therapy signal to the second dorsonasal structure; andimproving the subject's craniofacial pain via activation of the neurostimulator.2. The method of claim 1 , wherein the first dorsonasal structure and the second dorsonasal structure are the same structure.3. The method of claim 1 , wherein the first dorsonasal structure and the second dorsonasal structure are different structures.4. The method of claim 1 , wherein the neurostimulator is an electrical neurostimulator and the therapy signal is an electrical signal.5. The method of claim 1 , wherein the neurostimulator is a drug delivery device and the therapy signal is a chemical signal.6. The method of claim 1 , wherein the dorsonasal structure is a sphenopalatine ganglion.7. The method of claim 1 , wherein the identifying step comprise identifying if the subject is a candidate for implantation of a neurostimulator and wherein the placing step comprises implanting the neurostimulator adjacent to the second dorsal nasal structure.8. The method of claim 1 , wherein the determining step comprises determining if application of the anesthetic results in a short-term ...

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate configured for implantation within a body; an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; and an oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion. 1. An implantable heart treatment device , comprising:a substrate configured for implantation within a body;an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body; andan oxygenator coupled to the substrate and configured to supply one or more oxygenated molecules to one or more tissues of the heart within the body, the oxygenator including a blood inlet portion, a blood outlet portion, and an oxygen exchange portion positioned between the blood inlet portion and the blood outlet portion, the oxygen exchange portion including a high surface area oxygen exchanger configured to transfer one or more oxygenated molecules from the high surface area oxygen exchanger to blood passing from the blood inlet portion to the blood outlet portion.2. (canceled)3. The implantable heart treatment device of claim 1 , wherein the oxygenator includes a reservoir configured to store the one or more oxygenated molecules.4. The implantable heart ...

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Treatment of cardiac tissue via an implantable heart treatment device is described. A device embodiment includes, but is not limited to, a substrate; an electromagnetic signal generator configured to generate one or more electric signals configured to stimulate one or more tissues of a heart; a metabolic molecule supply device configured to supply one or more metabolic molecules to one or more tissues of the heart; and control circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, dependent upon a status of a ventricular fibrillation event of the heart. 1. An implantable heart treatment device , comprising:a substrate configured for implantation within a body;an electromagnetic signal generator coupled to the substrate and configured to generate one or more electric signals configured to stimulate one or more tissues of a heart within the body;a metabolic molecule supply device coupled to the substrate and configured to supply one or more metabolic molecules to one or more tissues of the heart within the body; andcontrol circuitry operably coupled to the electromagnetic signal generator and the metabolic molecule supply device, the control circuitry configured to generate one or more control signals according to at least a first control protocol and a second control protocol, the control circuitry configured to generate one or more control signals that cause the electromagnetic signal generator to generate the one or more electric signals upon execution of the first control protocol, the control circuitry configured to generate one or more control signals that cause the electromagnetic signal generator to generate the one or more electric signals and to generate one or more control signals that cause the metabolic molecule supply device to supply the one or more ...