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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 1589. Отображено 100.
11-10-2012 дата публикации

Charge balancing for arbitrary waveform generator & neural stimulation application

Номер: US20120259382A1
Автор: Jeffrey A. Weisgarber, Richard J. Polefko, Stephen Trier
Принадлежит: Greatbatch Ltd

A method, device and/or system for generating arbitrary waveforms of a desired shape that can be used for generating a stimulation pulse for medical purposes such as for spinal cord stimulation therapy, where such arbitrary waveforms can also be used for charge balancing purposes.

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Номер записи: 1
01-11-2012 дата публикации

Pacing and Stimulation Apparatus and Methods

Номер: US20120277813A1
Автор: Mark Zdeblick
Принадлежит: Proteus Digital Health Inc

System, device and method of variable pacing and stimulation are provided. In one example device, one or more lead integrated circuits may programmably control one or more variability parameters. One or more electrodes may provide electrical stimulation. Each electrode may be individually addressable by at least one of the lead integrated circuits and controlled by at least one variability parameter. Electrodes may be intentionally shorted together during time intervals that fall between times of stimulus, so as to dissipate potentials that might otherwise persist and cause electrode degradation.

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Номер записи: 2
01-11-2012 дата публикации

Electrode Stimulator with Energy Recycling and Current Regulation

Номер: US20120277830A1
Автор: Rahul Sarpeshkar, Scott K. Arfin
Принадлежит: Massachusetts Institute of Technology

A system and method for stimulating an electrode is provided. The stimulator includes a sensor circuit configured to couple to the at least one electrode of a medical device to measure a power characteristic of the at least one electrode. The stimulator includes a control circuit configured to compare the measured power characteristic of the at least one electrode to a desired power characteristic, and, based upon a comparison of the measured power characteristic of the at least one electrode and the desired power characteristic, select between a first operational mode and a second operational mode of the electrode stimulator. The first operational mode includes delivering energy to the at least one electrode to stimulate the tissue and the second operational mode includes recovering energy from the at least one electrode.

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Номер записи: 3
22-11-2012 дата публикации

Display of region of activation in neurostimulation programming screen

Номер: US20120296392A1
Автор: Changfang Zhu, Dongchul Lee
Принадлежит: Boston Scientific Neuromodulation Corp

A system for use with a neurostimulator coupled to one or more electrodes implanted adjacent neural tissue of a patient. The system comprises a user input device configured for allowing a user to select different nerve fiber diameters and to select a set of stimulation parameters. The system further comprises processing circuitry configured estimating regions of activation within the neural tissue of the patient based on the selected nerve fiber diameters and the selected stimulation parameter set. The system further comprises a display device configured for displaying the estimated regions of tissue activation. The user input device may further be configured for allowing the user to select different tissue regions of therapy, in which case, the display device may display the different tissue region on a human body map, and different indicia associating the displayed tissue regions for therapy to displayed estimated regions of tissue activation.

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Номер записи: 4
21-03-2013 дата публикации

Systems and Methods for Determining a Sleep Disorder Based on Positioning of the Tongue

Номер: US20130072999A1
Автор: Adi Mashiach
Принадлежит: Nyxoah SA

Devices and methods are disclosed that include an external unit comprising at least one processor. The processor may be configured to receive a signal indicative of tongue movement in a subject from an implant unit implanted in the subject, determine whether the tongue movement is representative of sleep disordered breathing, generate a modulation control signal to correct the sleep disordered breathing when the at least one processor determines an occurrence of sleep disordered breathing.

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Номер записи: 5
28-03-2013 дата публикации

Baroreflex modulation to gradually change a physiological parameter

Номер: US20130079838A1
Автор: Imad Libbus, Julio C. Spinelli
Принадлежит: Individual

An aspect of the present subject matter relates to a baroreflex stimulator. An embodiment of the stimulator includes a pulse generator to provide a baroreflex stimulation signal through an electrode, and a modulator. The modulator modulates the baroreflex stimulation signal to increase the baroreflex stimulation therapy by a predetermined rate of change to lower systemic blood pressure to a target pressure. Other aspects are provided herein.

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Номер записи: 6
04-04-2013 дата публикации

Devices and Methods for Delivering Energy as a Function of Condition Severity

Номер: US20130085541A1
Автор: Adi Mashiach
Принадлежит: Nyxoah SA

A device for regulating energy delivery to an implanted circuit is disclosed. The device may include at least one implantable circuit and at least one pair of implantable electrodes in electrical communication with the circuit. The at least one pair of implantable electrodes may be configured to modulate at least one nerve. The at least one implantable circuit may be configured deliver a signal to the at least one pair of implantable electrodes. The signal may have at least one of a power level or a duration determined based on a severity of a detected physiologic condition.

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Номер записи: 7
04-04-2013 дата публикации

Apparatus and Method for Controlling Energy Delivery as a Function of Degree of Coupling

Номер: US20130085542A1
Автор: Mashiach Adi
Принадлежит:

A device for delivering energy as a function of degree coupling may include an external unit configured for location external to a body of a subject and at least one processor associated with the implant unit and configured for electrical communication with a power source. The device may further include a primary antenna associated with the at least one processor. The processor may be configured to determine a degree of coupling between the primary antenna and a secondary antenna associated with the implant unit, and regulate delivery of power to the implant unit based on the degree of coupling between the primary antenna and the secondary antenna. 1. A sleep disordered breathing therapy device , comprising:a skin patch configured for temporary affixation on at least one of a neck and a head of a subject;a primary antenna associated with the skin patch;at least one processor associated with the skin patch and configured for electrical communication with a power sourcethe at least one processor further configured to communicate with an implant unit via the primary antenna when the implant unit is implanted in at least one of the neck and the head of the subject of the subject in a location proximate a hypoglossal nerve, and to determine a degree of coupling between the primary antenna and a secondary antenna associated with the implant unit, and to regulate delivery of power from the power source to the implant unit based on the degree of coupling between the primary antenna and the secondary antenna.2. The sleep disordered breathing therapy device of claim 1 , wherein the primary antenna includes a coil antenna.3. The sleep disordered breathing therapy device of claim 1 , wherein the skin patch includes a flexible substrate.4. The sleep disordered breathing therapy device of claim 1 , wherein the at least one processor is further configured to receive physiological data via the implant unit and regulate delivery of power from the power source to the implant unit ...

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Номер записи: 8
04-04-2013 дата публикации

Apparatus and Method for Extending Implant Life Using a Dual Power Scheme

Номер: US20130085543A1
Автор: Mashiach Adi, Mueller Carsten
Принадлежит:

A device according to some embodiments may include a housing configured for location external to a body of a subject. The device may also include at least one processor associated with the housing and configured for electrical communication with a power source, and an antenna associated with the at least one processor. The at least one processor may be configured to communicate with an implant circuit located within the body of the subject, cause the implant circuit to receive power in a first power mode and in a second power mode, wherein a first level of power delivered in the first power mode is less than a second level of power delivered in the second power mode, and wherein during a therapy period, power delivery in the first mode occurs over a total time that is greater than about 50% of the therapy period. 1. A device for the treatment of sleep disordered breathing , the device comprising:a housing configured for temporary affixation on at least one of a neck and a head of a subject; andat least one processor associated with the housing and configured for electrical communication with a power source; andan antenna associated with the at least one processor; communicate with an implant circuit in at least one of the neck and the head of the subject of the subject in a location proximate a hypoglossal nerve,', 'cause the implant circuit to receive power in a first power mode and in a second power mode, wherein a first level of power delivered in the first power mode is less than a second level of power delivered in the second power mode, and wherein during a therapy period, power delivery in the first mode occurs over a total time that is greater than about 50% of the therapy period., 'the at least one processor being configured to2. The device of claim 1 , wherein the implant circuit is associated with electrodes claim 1 , and wherein during the first power mode claim 1 , the at least one processor causes a first alternating current signal to supply power to ...

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Номер записи: 9
04-04-2013 дата публикации

Apparatus and Method to Control an Implant

Номер: US20130085544A1
Автор: Adi Mashiach
Принадлежит: Nyxoah SA

A device according to some embodiments of the present disclosure includes a housing configured to retain a battery, a primary antenna associated with the housing, and at least one processor in electrical communication with the battery and the primary antenna. In some embodiments, the at least one processor may be configured to cause transmission of a primary signal from the primary antenna to an implantable device during a treatment session of at least three hours in duration, wherein the primary signal is generated using power supplied by the battery and includes a pulse train, the pulse train including a plurality of modulation pulses.

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Номер записи: 10
04-04-2013 дата публикации

Device and Method for Modulating Nerves Using Parallel Electric Fields

Номер: US20130085558A1
Автор: Adi Mashiach
Принадлежит: Nyxoah SA

A device may include at least one pair of modulation electrodes configured for implantation in the vicinity of a nerve to be modulated such that the electrodes are spaced apart from one another along a longitudinal direction of the nerve to be modulated. The electrodes may be further configured to facilitate an electric field in response to an applied electric signal, the electric field including field lines extending in the longitudinal direction of the nerve to be modulated. The device may further include at least one circuit in electrical communication with the at least one pair of modulation electrodes and being configured to cause application of the electric signal applied at the at least one pair of modulation electrodes.

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Номер записи: 11
04-04-2013 дата публикации

System and Method for Nerve Modulation Using Noncontacting Electrodes

Номер: US20130085560A1
Автор: Adi Mashiach
Принадлежит: Nyxoah SA

An implant unit configured for implantation into a body of a subject may include an antenna configured to receive a signal. The implant unit may also include at least one pair of modulation electrodes configured to be implanted into the body of the subject in the vicinity of at least one nerve to be modulated, the at least one pair of modulation electrodes being configured to receive an applied electric signal in response to the signal received by the antenna and generate an electrical field to modulate the at least one nerve from a position where the at least one pair of modulation electrodes does not contact the at least one nerve.

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Номер записи: 12
06-06-2013 дата публикации

SYSTEM AND METHOD FOR INCREASING RELATIVE INTENSITY BETWEEN CATHODES AND ANODES OF NEUROSTIMULATION SYSTEM USING PULSE SLICING

Номер: US20130144362A1
Автор: Lee Dongchul
Принадлежит: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

A method and neurostimulation system for providing therapy to a patient is provided. A plurality of electrodes is placed adjacent to tissue of the patient. A plurality of first electrical pulses is delivered to a first set of the electrodes, at least a second electrical pulse is delivered to a second set of the electrodes during the deliverance of each of the first electrical pulses, and at least a third electrical pulse is delivered to a third set of the electrodes during the deliverance of each of the first electrical pulses. The first electrical pulses have a first polarity, and each of the second electrical pulse(s) and third electrical pulses(s) has a second a second polarity opposite to the first polarity. The second and third electrical pulses are temporarily offset from each other. 1. A method of providing therapy to a patient , comprising:implanting a plurality of electrodes within the patient;delivering a plurality of first electrical pulses to a first set of the electrodes, the first electrical pulses having a first polarity;delivering at least a second electrical pulse having a second polarity opposite to the first polarity to a second set of the electrodes during the deliverance of each of the first electrical pulses, wherein the at least a second electrical pulse therapeutically stimulates tissue of the patient; anddelivering at least a third electrical pulse having the second polarity to a third set of the electrodes during the deliverance of each of the first electrical pulses, wherein the second and third electrical pulses are temporarily offset from each other.2. The method of claim 1 , wherein the at least a second electrical pulse comprises a plurality of electrical pulses.3. The method of claim 1 , wherein the at least a third electrical pulse therapeutically stimulates tissue of the patient.4. The method of claim 1 , wherein the at least a third electrical pulse does not therapeutically stimulate tissue of the patient.5. The method of claim 1 , ...

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Номер записи: 13
13-06-2013 дата публикации

Method for direct modulation of the dorsolateral funiculus

Номер: US20130150920A1
Автор: Kerry Bradley
Принадлежит: Boston Scientific Neuromodulation Corp

A method for treating a patient suffering from chronic neuropathic pain, comprises epidurally applying electrical stimulation energy to a dorsolateral funiculus of the patient, thereby treating the chronic neuropathic pain. The method may further comprise increasing the activation threshold of a side-effect exhibiting neural structure relative to the activation threshold of the dorsolateral funiculus of the patient, wherein the electrical stimulation energy is applied to the dorsolateral funiculus of the patient while the activation threshold of the neural structure relative to the dorsolateral funiculus is increased, thereby treating the chronic neuropathic pain without stimulating the neural structure.

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Номер записи: 14
26-09-2013 дата публикации

AUTOMATIC SELECTION OF LEAD CONFIGURATION FOR A NEURAL STIMULATION LEAD

Номер: US20130253615A1
Автор: Arcot-Krishnamurthy Shantha, Hamann Jason, Hincapie Ordonez Juan Gabriel, Ruble Stephen B., Ternes David J.
Принадлежит: Cardiac Pacemakers, Inc.

A neurostimulation system includes a neural stimulation lead having a proximal portion and a distal portion and including a plurality of electrodes along the distal portion. The plurality of electrodes are configured for positioning proximate a portion of the autonomic nervous system. A neural stimulation circuit, coupled to the plurality of electrodes, delivers neural stimulation pulses to the plurality of electrodes. A processor and controller is configured to control the neural stimulation circuit to deliver first neural stimulation pulses to each of a plurality of electrode configurations. Each electrode configuration includes one or more of the plurality of electrodes. The processor and controller is further configured to receive information related to motor fiber activity that is induced in response to delivery of the first neural stimulation pulses to each of the plurality of electrode configurations and to identify the electrode configurations that induce the motor fiber activity. 1. A neurostimulation system comprising:a neural stimulation lead having a plurality of electrodes, the plurality of electrodes configured for positioning proximate a portion of the autonomic nervous system;a neural stimulation circuit, coupled to the plurality of electrodes, to deliver neural stimulation pulses to the plurality of electrodes;a user interface, the user interfacing including a display; and control the neural stimulation circuit to deliver first neural stimulation pulses to each of a plurality of electrode configurations, each electrode configuration comprising one or more of the plurality of electrodes,', 'receive information related to motor fiber activity that is induced in response to delivery of the first neural stimulation pulses to each of the plurality of electrode configurations,', 'prioritize the plurality of electrode configurations based on a first capture threshold of the motor fiber activity,', 'control the neural stimulation circuit to deliver second ...

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Номер записи: 15
21-11-2013 дата публикации

Pulse-by-Pulse Compliance Voltage Generation for an Implantable Stimulator

Номер: US20130310897A1
Автор: Marnfeldt Goran, Shi Jess
Принадлежит: Boston Scientific Neuromodulation Corportion

Circuitry for generating a compliance voltage (V+) for the current sources and/or sinks in an implantable stimulator device in disclosed. The circuitry assesses whether V+ is optimal for a given pulse, and if not, adjusts V+ for the next pulse. The circuitry uses amplifiers to measure the voltage drop across active PDACs (current sources) and NDAC (current sinks) at an appropriate time during the pulse. The measured voltages are assessed to determine whether they are high or low relative to optimal values. If low, a V+ regulator is controlled to increase V+ for the next pulse; if not, the V+ regulator is controlled to decrease V+ for the next pulse. Through this approach, gradual changes that may be occurring in the implant environment can be accounted for, with V+ adjusted on a pulse-by-pulse basis to keep the voltage drops at or near optimal levels for efficient DAC operation. 1. Circuitry configured to adjust a compliance voltage in an implantable stimulator device , comprising:a source circuit coupled to a compliance voltage, wherein the source circuit is configured to provide a first current pulse to at least a first electrode;a sink circuit coupled to a reference voltage, wherein the sink circuit is configured to sink the first current pulse from at least a second electrode;a first amplifier configured to measure a first voltage across the source circuit;a second amplifier configured to measure a second voltage across the sink circuit;a first comparator configured to compare the measured first voltage to an optimal first voltage and to produce a first digital signal indicating whether the measured first voltage is high or low relative to the optimal first voltage;a second comparator configured to compare the measured second voltage to an optimal second voltage and to produce a second digital signal indicating whether the measured second voltage is high or low relative to the optimal second voltage;logic circuitry configured to assess the first and second ...

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Номер записи: 16
19-12-2013 дата публикации

METHOD AND APPARATUS FOR CONTROLLING STIMULATION PULSES DURING THE PROGRAMMING OF AN IMPLANTABLE PULSE GENERATOR

Номер: US20130338733A1
Автор: Avedikian Jonathan, Goddard Crystal, Overton Karen, Pounds Jason, Younker Tom
Принадлежит: ADVANCED NEUROMODULATION SYSTEMS, INC.

In one embodiment, a method for the controlling of the stimulation pulses being delivered via electrodes to a patient during the programming of a pulse generator using a controller device and selecting of a minimum amplitude that corresponds to the minimum amplitude for which the patient can detect stimulation; selecting an electrode combination defined in the controller device; setting the stimulation amplitude; making a determination of the amplitude for the stimulation pulses is greater than the perception amplitude, and if so, changing the amplitude of the stimulation pulses to be less than or equal to the perception amplitude; and if not or subsequent to the changing of the amplitude, changing the selected one of a plurality of electrode combinations to a different combination. 1. A method for controlling stimulation pulses applied via a plurality of electrodes to tissue of a patient during the programming of a pulse generator using a controller device by a user , comprising:selecting a first combination of electrodes;setting the value for a stimulation parameter for the stimulation pulses to be applied to the first combination of electrodes;receiving input from the user to change the first combination of electrodes to a second combination of electrodes;determining if the value for the stimulation parameter for the stimulation pulses is different than a predetermined value, and if the determination is positive, automatically changing the value for stimulation parameter for the stimulation pulses to be equal to the predetermined value; andif the determination is negative or subsequent to the changing of the value for the stimulation parameter for the stimulation pulses, changing the selected first combination of electrodes to the second combination of electrodes.2. The method of claim 1 , determining a perception value corresponding to the minimum stimulation parameter for the stimulation pulses where the patient perceives stimulation.3. The method of claim 2 , ...

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Номер записи: 17
02-01-2014 дата публикации

CONCURRENT THERAPY DETECTION IN IMPLANTABLE MEDICAL DEVICES

Номер: US20140005494A1
Автор: Baker Kenneth L., Hamann Jason J., Ruble Stephen, Ternes David J.
Принадлежит: Cardiac Pacemakers, Inc.

Various method embodiments detect a concurrent therapy, where the concurrent therapy includes a plurality of therapy pulses. Detecting the concurrent therapy includes detecting at least one electrical pulse, extracting at least one characteristic from the at least one electrical pulse, comparing the at least one characteristic of the detected pulse to at least one characteristic of therapy pulses, and detecting that the concurrent therapy is being applied if the at least one characteristic of the detected pulse favorably compares to the at least one characteristic of the therapy pulses. 1. A method , comprising: detecting at least one electrical pulse;', 'extracting at least one characteristic from the at least one electrical pulse;', 'comparing the at least one characteristic of the detected pulse to at least one characteristic of therapy pulses; and', 'detecting that the concurrent therapy is being applied if the at least one characteristic of the detected pulse favorably compares to the at least one characteristic of the therapy pulses., 'detecting a concurrent therapy, wherein the concurrent therapy includes a plurality of therapy pulses, wherein detecting a concurrent therapy includes2. The method of claim 1 , wherein detecting the at least one electrical pulse includes detecting a rising edge or a falling edge of the electrical pulse.3. The method of claim 2 , wherein detecting the rising edge or the falling edge of the electrical pulse includes detecting both the rising edge and the falling edge of the electrical pulse.4. The method of claim 2 , wherein detecting the rising edge or a falling edge of the electrical pulse includes applying a high frequency filter to transform a sensed pulse signal into a transformed signal claim 2 , wherein the transformed signal has spikes corresponding to transitions at the rising and falling edges of the sensed pulse.5. The method of claim 4 , wherein extracting includes extracting a pulse width from the at least one ...

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Номер записи: 18
13-02-2014 дата публикации

Systems and methods for restoring muscle function to the lumbar spine

Номер: US20140046398A1
Автор: Dan Sachs, Jason Alan Shiroff, Peter Andrew Crosby, Prashant Brijmohansingh Rawat
Принадлежит: Mainstay Medical Ltd

A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters.

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Номер записи: 19
13-03-2014 дата публикации

COUPLED MONOPOLAR AND MULTIPOLAR PULSING FOR CONDITIONING AND STIMULATION

Номер: US20140074189A1
Автор: Moffitt Michael A.
Принадлежит: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

A method and neurostimulation system of providing therapy to a patient is provided. A plurality of electrodes are placed in contact with tissue of a patient, a conditioning pulse is conveyed from the plurality of electrodes in one of a monopolar manner and a multipolar manner, and a stimulation pulse is conveyed from the plurality of electrodes in a different one of the monopolar manner and the multipolar manner. As one example, the sub-threshold conditioning pulse may be a depolarizing pulse conveyed from the plurality of electrodes to render a first region of the tissue less excitable to stimulation, and the stimulation pulse may be conveyed from the plurality of electrodes to stimulate a second different region of the tissue. 1. A method of providing therapy to a patient , comprising:placing a plurality of electrodes in contact with tissue of a patient;conveying at least one conditioning pulse from the plurality of electrodes in one of a monopolar manner and a multipolar manner; andconveying at least one stimulation pulse from the plurality of electrodes in a different one of the monopolar manner and the multipolar manner.2. The method of claim 1 , wherein the at least one conditioning pulse is at least one depolarizing pulse conveyed from the plurality of electrodes to render a first region of the tissue less excitable to stimulation claim 1 , and the at least one stimulation pulse is conveyed from the plurality of electrodes to stimulate a second different region of the tissue.3. The method of claim 2 , wherein the first tissue region is one or more dorsal root nerve fibers claim 2 , and the second tissue region is one or more dorsal column nerve fibers.4. The method of claim 2 , wherein the first tissue region is one or more dorsal column nerve fibers claim 2 , and the second tissue region is one or more dorsal root nerve fibers.5. The method of claim 1 , wherein the at least one conditioning pulse is at least one hyperpolarizing pulse conveyed from the ...

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Номер записи: 20
10-04-2014 дата публикации

Modulator Apparatus Configured for Implantation

Номер: US20140100641A1
Автор: Adi Mashiach
Принадлежит: Cephalix SA

An implant unit according to some embodiments may include a flexible carrier, at least one pair of modulation electrodes on the flexible carrier, and at least one implantable circuit in electrical communication with the at least one pair of modulation electrodes. The at least one pair of modulation electrodes and the at least one circuit may be configured for implantation through derma on an underside of a subject's chin and for location proximate to terminal fibers of the medial branch of the subject's hypoglossal nerve, such that an electric field extending from the at least one pair of modulation electrodes can modulate one or more of the terminal fibers of the medial branch of the hypoglossal nerve.

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Номер записи: 21
10-04-2014 дата публикации

System and method for nerve modulation using noncontacting electrodes

Номер: US20140100642A1
Автор: Adi Mashiach
Принадлежит: Hyllio SA

An implant unit configured for implantation into a body of a subject may include an antenna configured to receive a signal. The implant unit may also include at least one pair of modulation electrodes configured to be implanted into the body of the subject in the vicinity of at least one nerve to be modulated, the at least one pair of modulation electrodes being configured to receive an applied electric signal in response to the signal received by the antenna and generate an electrical field to modulate the at least one nerve from a position where the at least one pair of modulation electrodes does not contact the at least one nerve.

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Номер записи: 22
04-01-2018 дата публикации

Display of region of activation in neurostimulation programming screen

Номер: US20180001092A1
Автор: Changfang Zhu, Dongchul Lee
Принадлежит: Boston Scientific Neuromodulation Corp

A system for use with a neurostimulator coupled to one or more electrodes implanted adjacent neural tissue of a patient. The system comprises a user input device configured for allowing a user to select different nerve fiber diameters and to select a set of stimulation parameters. The system further comprises processing circuitry configured estimating regions of activation within the neural tissue of the patient based on the selected nerve fiber diameters and the selected stimulation parameter set. The system further comprises a display device configured for displaying the estimated regions of tissue activation. The user input device may further be configured for allowing the user to select different tissue regions of therapy, in which case, the display device may display the different tissue region on a human body map, and different indicia associating the displayed tissue regions for therapy to displayed estimated regions of tissue activation.

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Номер записи: 23
02-01-2020 дата публикации

NEUROMODULATION CALIBRATION BASED ON NEUROPHYSIOLOGICAL SIGNALS

Номер: US20200001086A1
Автор: Doan Que T., Fernandez Ismael Huertas
Принадлежит:

A system may include at least one sensor configured to bilaterally sense neurophysiological signals from the patient to provide bilateral sensing data, and at least one processor configured to calibrate at least a first electrode contact and a second electrode contact on the least one neuromodulation lead, including: instruct the neuromodulation device to deliver neuromodulation energy using at least the first electrode contact to cause a first neurophysiological response and at least the second electrode contact to cause a second neurophysiological response; receive from the at least one sensor first bilateral sensed data corresponding to the first neurophysiological response and second bilateral sensed data corresponding to the second neurophysiological response; and determine based on the first and second neurophysiological responses at least one of: physiological midline information or electrode-tissue coupling information. 1. A method performed using a neuromodulation device connected to at least one neuromodulation lead and configured to deliver neuromodulation energy to spinal cord tissue in a patient using the at least one neuromodulation lead , at least one processor , and at least one sensor configured to bilaterally sense neurophysiological signals from a patient to provide bilateral sensing data , wherein the method comprises calibrating at least a first electrode contact and a second electrode contact on the least one neuromodulation lead , including using the at least one processor to:instruct the neuromodulation device to deliver neuromodulation energy using at least the first electrode contact to cause a first neurophysiological response and using at least the second electrode contact of the lead to cause a second neurophysiological response;receive from the at least one sensor first bilateral sensed data corresponding to the first neurophysiological response and second bilateral sensed data corresponding to the sensed neurophysiological response; ...

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Номер записи: 24
03-01-2019 дата публикации

Implantable Medical Device with a Stylet Channel

Номер: US20190001136A1
Автор: Hahn Benjamin P., Howard Joshua D., Pianca Anne M.
Принадлежит:

An implantable stimulator device is disclosed preferably having a lead portion and an electronics module integrated and implantable as a single unit, which can enable trial stimulation to occur in a fully implanted solution for a lengthened or unlimited duration. The side of the housing of the electronic module includes a stylet channel which proceeds through the housing at an angle to the implantable stimulator's long axis and bends to proceed through the lead portion along the long axis. The stylet channel can receive a lead stylet to allow the lead portion and the electronics module to be properly positioned within the patient. Because the proximal end of the lead stylet exits the housing of the electronics module at an angle, it provides a handle to steer the lead portion for proper placement within the spinal column. 1. An implantable stimulator device , comprising:an electronics module having a housing with a side parallel to a long axis of the device, the housing containing stimulation circuitry configured to generate electrical stimulation;a lead portion coupled to the housing, the lead portion comprising at least one electrode configured to provide the electrical stimulation to a patient's tissue, wherein the lead portion is parallel to the long axis; anda stylet channel configured to receive a lead stylet that assists with implantation of the implantable stimulator device in a patient, wherein the stylet channel passes through an opening on the side of the housing and through the lead portion.2. The implantable stimulator device of claim 1 , wherein the side of the housing comprises at least a cylindrical portion.3. The implantable stimulator device of claim 1 , wherein the side of the housing comprises at least a flat portion claim 1 , and wherein the side comprises one of first and second parallel major sides of the housing.4. The implantable stimulator device of claim 1 , further comprising a circuit board contained within the housing claim 1 , wherein ...

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Номер записи: 25
03-01-2019 дата публикации

SYSTEM FOR NEUROMODULATION

Номер: US20190001138A1
Автор: Courtine Gregoire, MINASSIAN Karen, WAGNER Fabien
Принадлежит:

The present disclosure relates to a system for neuromodulation and/or neurostimulation, for the treatment of a subject. The system comprises a stimulation controller, a stimulation pattern storage means including stimulation data connected to the stimulation controller, an electrical stimulation device and electrical interface between the electrical stimulation device and the subject, the electrical interface being connectable with a bio-interface of the nervous system of the subject. The stimulation data are pre-programmed patterns comprising spatial and temporal components, The stimulation controller sends configuration signals on the basis of the stimulation data to the electrical stimulation device such that via the electrical interface electrical stimulation is provided to the bio-interface, wherein the electrical stimulation provided is characterized by stimulation parameters that vary over time in a pre-programmed manner. 1. A system for neuromodulation and/or neurostimulation , for the treatment of a subject , comprising at least a stimulation controller , at least a stimulation pattern storage drive which is connected to the stimulation controller and which comprises a stimulation data , at least an electrical stimulation device , at least an electrical interface between the electrical stimulation device and the subject , the electrical interface being connectable with at least a bio-interface of or with a nervous system of the subject , wherein the electrical interface and the bio-interface are arranged such that signals and/or data are exchanged from the electrical interface to the bio-interface or vice versa , wherein the stimulation data are pre-programmed patterns which comprise at least a spatial component which is related to a part of the nervous system being stimulated and a temporal component which is related to a time at which the spatial component is applied; andwherein the stimulation controller is capable to send configuration signals on a ...

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Номер записи: 26
03-01-2019 дата публикации

APPARATUS WITH ENHANCED STIMULATION WAVEFORMS

Номер: US20190001139A1
Автор: FLAHERTY J. Christopher, HARTLEY Lee Fason, Makous James C., Mishra Lakshmi Narayan, PIVONKA Daniel M.
Принадлежит:

A medical apparatus for a patient comprises an implantable system. The implantable system comprises a first implantable device comprising: at least one implantable functional element configured to deliver stimulation energy to tissue of the patient; and an implantable controller configured to provide a stimulation waveform to the at least one implantable functional element, the stimulation waveform comprising one or more stimulation parameters. The apparatus is configured to randomly vary at least one of the one or more stimulation parameters. Methods of providing stimulation energy with randomly varying stimulation parameters are also provided. 1. A medical apparatus for a patient , comprising:an implantable systemwherein the implantable system comprises a first implantable device comprising:at least one implantable functional element configured to deliver stimulation energy to tissue of the patient; andan implantable controller configured to provide a stimulation waveform to the at least one implantable functional element, the stimulation waveform comprising one or more stimulation parameters,wherein the apparatus is configured to randomly vary at least one of the one or more stimulation parameters.2. The medical apparatus according to any claim herein , wherein the apparatus is configured to treat pain.3. The medical apparatus according to claim 2 , wherein the apparatus is configured to treat pain selected from the group consisting of: back pain; joint pain; neuropathic pain; tennis elbow; muscle pain; shoulder pain; chronic claim 2 , intractable pain of the back; chronic intractable pain of the lower limbs; unilateral pain; bilateral pain; neuropathic groin pain; perineal pain; phantom limb pain; complex regional pain syndrome; failed back surgery syndrome; cluster headaches; migraines; inflammatory pain; arthritis; abdominal pain; pelvic pain; and combinations thereof.4. The medical apparatus according to claim 2 , wherein the apparatus is configured to ...

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Номер записи: 27
14-01-2021 дата публикации

Pulsed Passive Charge Recovery Circuitry for an Implantable Medical Device

Номер: US20210008365A1
Автор: Featherstone Adam T., Feldman Emanuel, Marnfeldt Goran N., Parramon Jordi
Принадлежит:

The problem of a potentially high amount of supra-threshold charge passing through the patient's tissue at the end of an Implantable Pulse Generator (IPG) program is addressed by circuitry that periodically dissipates only small amount of the charge stored on capacitances (e.g., DC-blocking capacitors) during a pulsed post-program recovery period. This occurs by periodically activating control signals to turn on passive recovery switches to form a series of discharge pulses each dissipating a sub-threshold amount of charge. Such periodic pulsed dissipation may extend the duration of post-program recovery, but is not likely to be noticeable by the patient when the programming in the IPG changes from a first to a second program. Periodic pulsed dissipation of charge may also be used during a program, such as between stimulation pulses. 1. A pulse generator , comprising:a plurality of electrode nodes, wherein each electrode node is configured to be coupled to one of a plurality of electrodes in contact with a patient's tissue;a reference voltage;a plurality of switches, wherein each of the switches is configured to couple the reference voltage to a different one of the electrode nodes;stimulation circuitry configured to provide stimulation pulses to two or more of the electrode nodes; andcontrol circuitry configured to repeatedly close and open at least some of the plurality of switches during a time period when the stimulation circuitry is not providing stimulation pulses, wherein the time period occurs between successive stimulation pulses provided to the two or more of the electrode nodes.2. The pulse generator of claim 1 , wherein the control circuitry is configured to select and repeatedly close and open only the switches coupled to the two or more electrode nodes during the time period.3. The pulse generator of claim 1 , wherein the control circuitry is configured to repeatedly close and open all of the switches during the time period.4. The pulse generator of ...

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Номер записи: 28
08-01-2015 дата публикации

Neurostimulator Configured to Sense Evoked Potentials in Peripheral Nerves

Номер: US20150012064A1
Автор: Bradley Kerry, Chen Joey, Halberg Leslie
Принадлежит:

A method of providing stimulation therapy to a patient includes performing first and second calibration processes in first and second patient posture states, respectively. The first and second calibration processes respectively associates a sensation experienced by a patient, in the respective patient posture states, with first and second amounts of an evoked potential, respectively, and also with first and second values of a stimulation parameter to achieve the first and second amounts of evoked potential, respectively. Thereafter, a current patient posture state is detected. If the current patient posture state is detected as the first patient posture state, stimulation therapy is applied to the patient using the first value of the stimulation parameter as an initial value. If the current patient posture state is detected as the second patient posture state, stimulation therapy is applied to the patient using the second value of the stimulation parameter as the initial value. 1. A method of providing a stimulation therapy to a patient , the method comprising:performing a first calibration process in a first patient posture state, wherein the first calibration process associates a sensation experienced by a patient, in the first patient posture state, with a first amount of an evoked potential and a first value of a stimulation parameter for the stimulation therapy to achieve the first amount of evoked potential;performing a second calibration process in a second patient posture state, wherein the second calibration process associates the sensation experienced by a patient, in the second patient posture state, with a second amount of the evoked potential and a second value of the stimulation parameter for the stimulation therapy to achieve the second amount of evoked potential;detecting, after the first and second calibration processes have been performed, a current patient posture state;if the current patient posture state is detected as the first patient posture ...

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Номер записи: 29
08-01-2015 дата публикации

SYSTEM AND METHOD FOR SELECTIVE AND MAINTAINED ACTIVATION OF SENSORY PERIPHERAL NERVE FIBERS

Номер: US20150012068A1
Автор: Bradley Kerry, Halberg Les
Принадлежит:

A method of establishing a stimulation treatment protocol includes delivering electrical stimulation to a nerve site of the patient. The electrical stimulation is delivered using a stimulation configuration with respect to one or more of the following: activation of a subset of a plurality of electrodes on a lead, electrode polarity for the activated electrodes, stimulation pulse width, and stimulation pulse amplitude. An action potential evoked from the nerve site in response to the electrical stimulation is measured. The action potential includes a sensory fiber contribution and a motor fiber contribution. Both the sensory fiber contribution and the motor fiber contribution are measured. The delivering and the measuring are repeated for a plurality of cycles. Each cycle is performed using a different stimulation configuration. The stimulation configuration that offers a greatest sensory fiber contribution relative to the motor fiber contribution is recommended as a candidate for optimized stimulation configuration. 1. A method of establishing a stimulation treatment protocol for a patient , the method comprising:delivering electrical stimulation to a nerve site of the patient, wherein the electrical stimulation is delivered using a stimulation configuration with respect to one or more of the following: activation of a subset of a plurality of electrodes on a lead, electrode polarity for the activated electrodes, stimulation pulse width, and stimulation pulse amplitude;measuring an action potential evoked from the nerve site in response to the electrical stimulation, wherein the action potential includes a sensory fiber contribution and a motor fiber contribution, and wherein the measuring comprises measuring the sensory fiber contribution and the motor fiber contribution;repeating the delivering and the measuring for a plurality of cycles, wherein each cycle is performed using a different stimulation configuration; andthereafter recommending, as a candidate for ...

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Номер записи: 30
03-02-2022 дата публикации

Dorsal root ganglion stimulation in influencing organ function

Номер: US20220032058A1
Автор: Berthold Stegemann, Jules Hamers, Lilian Kornet, Mirko de Melis, Richard Cornelussen
Принадлежит: MEDTRONIC INC

Systems and methods are directed to influencing organ function by stimulating the dorsal root ganglion. Systems include at least one electrode to deliver electrical stimulation to the dorsal root ganglion to activate afferent nerves innervating at least one organ, and computing apparatus comprising one or more processors operably coupled to the at least one electrode to control the electrical stimulation.

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Номер записи: 31
17-01-2019 дата публикации

CURRENT SENSING MULTIPLE OUTPUT CURRENT STIMULATORS

Номер: US20190015664A1
Автор: LEE EDWARD K.F.
Принадлежит: ALFRED E. MANN FOUNDATION FOR SCIENTIFIC RESEARCH

A multiple output current stimulator circuit with fast turn on time is described. At least one pair of input side and output side transistors is arranged in a current mirror connected to a supply transistor by cascode coupling. The output side transistor supplies stimulation current to an electrode in contact with tissue. An operational amplifier connected to a reference voltage and to the output side transistor drives the supply transistor to maintain the voltage at the output side transistor equal to the reference voltage. The at least one pair of transistors includes multiple pairs of transistors whose output side transistors drive respective electrodes with stimulation currents. The stimulator determines the initiation and duration of stimulation current pulses supplied to each electrode. At circuit activation, large currents are generated which discharge capacitances in the output side transistors causing rapid output side transistor turn on. 117-. (canceled)18. A method of providing stimulation comprising:implanting a pulse generator configured to generate one or several electrical pulses in a portion of a body, the pulse generator comprising a stimulator circuit, wherein the stimulator circuit comprises a supply transistor having an output connected to one or several gates of one or several output transistors;implanting a lead within the portion of the body, wherein the lead comprises one or more electrodes;positioning the one or more electrodes of the lead proximate to a nerve; andconnecting the lead to the pulse generator.19. The method of providing stimulation of claim 18 , further comprising generating an electrical pulse with the pulse generator; and conducting the electrical pulse to the nerve with the lead.20. The method of providing stimulation of claim 18 , wherein the stimulator circuit further comprises a current source.21. The method of providing stimulation of claim 20 , wherein the implantable pulse generator further comprises a switching ...

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Номер записи: 32
16-01-2020 дата публикации

GRAPHICAL USER INTERFACE FOR PROGRAMMING NEUROSTIMULATION PULSE PATTERNS

Номер: US20200016409A1
Автор: Kothandaraman Sridhar, Moffitt Michael A.
Принадлежит:

An example of a neurostimulation system may include a storage device, a programming control circuit, and a graphical user interface (GUI). The storage device may be configured to store individually definable waveforms. The programming control circuit may be configured to generate stimulation parameters controlling the delivery of the neurostimulation pulses according to a pattern. The GUI may be configured to define the pattern using one or more waveforms selected from the individually definable waveforms. The GUI may display waveform tags each selectable for access to a waveform of the individually definable waveforms, and display a waveform builder in response to selection of one of the waveform tags. The waveform builder may present a graphical representation of the accessed waveform and allow for the accessed waveform to be adjusted by editing the graphical representation of the accessed waveform on the GUI. 1. A system for controlling delivery of neurostimulation by a user , the neurostimulation delivered using a plurality of electrodes , the system comprising:a programming control circuit configured to generate stimulation parameters for programming the neurostimulation device to deliver the neurostimulation according to a pattern of neurostimulation pulses;a storage device configured to store individually definable waveforms; and organize the stored individually definable waveforms into a hierarchical structure including multiple levels and allow each waveform of each level of the multiple levels to include one or more waveforms of one or more lower levels when the each level is above the lowest level of the hierarchical structure;', 'allow the user to graphically create a new waveform for each level of the hierarchical structure to be added to the stored individually definable waveforms by including one or more waveforms selected from the stored individually definable waveforms at one or more lower levels of the hierarchical structure when the each level is ...

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Номер записи: 33
21-01-2021 дата публикации

SYSTEM FOR NEUROMODULATION

Номер: US20210016093A1
Автор: Courtine Gregoire, MINASSIAN Karen, WAGNER Fabien
Принадлежит:

The present disclosure relates to a system for neuromodulation and/or neurostimulation, for the treatment of a subject. The system comprises a stimulation controller, a stimulation pattern storage means including stimulation data connected to the stimulation controller, an electrical stimulation device and electrical interface between the electrical stimulation device and the subject, the electrical interface being connectable with a bio-interface of the nervous system of the subject. The stimulation data are pre-programmed patterns comprising spatial and temporal components, The stimulation controller sends configuration signals on the basis of the stimulation data to the electrical stimulation device such that via the electrical interface electrical stimulation is provided to the bio-interface, wherein the electrical stimulation provided is characterized by stimulation parameters that vary over time in a pre-programmed manner. 1. A system for neuromodulation and/or neurostimulation , for the treatment of a subject , comprising at least a stimulation controller , at least a stimulation pattern storage drive which is connected to the stimulation controller and which comprises stimulation data , at least an electrical stimulation device , at least an electrical interface between the electrical stimulation device and the subject , the electrical interface being connectable with at least a bio-interface of or with a nervous system of the subject , wherein the electrical interface and the bio-interface are arranged such that signals and/or data are exchanged from the electrical interface to the bio-interface or vice versa , wherein the stimulation data are pre-programmed patterns which comprise at least a spatial component which is related to a part of the nervous system being stimulated and a temporal component which is related to a time at which the spatial component is applied; andwherein the stimulation controller is capable to send configuration signals on a basis ...

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Номер записи: 34
21-01-2021 дата публикации

PROGRAMMABLE AUTOTITRATING OF ELECTRICAL PARAMETERS OF IMPLANTABLE MEDICAL DEVICE

Номер: US20210016094A1
Автор: Osorio Ivan
Принадлежит: FLINT HILLS SCIENTIFIC, L.L.C.

We report a method of automatically titrating an electrical therapy administered to a patient by an implanted medical device to a target dosage, comprising programming the medical device with a programmed electrical therapy comprising a first target value for a first therapy parameter; programming at least one titration parameter for automatically adjusting the first therapy parameter from a first value to the first target value over a titration time period initiating the electrical therapy, wherein the first therapy parameter comprises said first value; and automatically titrating the electrical therapy by making a plurality of adjustments to the value of the first therapy parameter, whereby the first electrical therapy parameter is changed from the first value to the first target value according to a titration function. We also report a medical device system configured to implement the method. 1. A method of treating a medical condition of a patient via an implantable medical device comprising:initiating via one or more processors of the implantable medical device a titration period for a first therapy with a first treatment period based on an input obtained from the patient, the first therapy including an electrical stimulation with one or more parameters;initiating a modification procedure of one or more values associated with the one or more parameters during the titration period; andinitiating the first therapy for the first treatment period based on one or more parameters being tolerated by the patient or reaching one or more target values.2. The method of claim 1 , further comprising initiating a second titration period for a second therapy with a second treatment period.3. The method of claim 2 , further comprising initiating a third therapy based on an acute event detection.4. The method of claim 3 , further comprising initiating a third therapy based on the acute event detection.5. The method of claim 1 , wherein one or more changes in the one or more ...

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Номер записи: 35
28-01-2016 дата публикации

Stimulation patterns for treating dry eye

Номер: US20160022992A1
Автор: James Donald Loudin, Manfred Franke
Принадлежит: Oculeve Inc

Described herein are electrical stimulation patterns and methods of use thereof for treating dry eye disease, tired eye, or other forms of ocular discomfort. The methods generally include applying patterned stimulation to an anatomical structure located in an ocular region or a nasal region to increase tear production.

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Номер записи: 36
24-01-2019 дата публикации

STIMULATION DEVICES AND METHODS FOR TREATING DRY EYE

Номер: US20190022392A1
Автор: FRANKE Manfred, HOLDBROOK Mark Jeffrey, LOUDIN James Donald, WARDLE John
Принадлежит:

Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described. 1. A method for treating dry eye in a patient in need thereof , comprising:contacting nasal mucosa of the patient with a first electrode; anddelivering current from the electrode through tissue of the patient to a return contact,wherein the electrode is located on a nasal insertion prong of a stimulator probe of a stimulator, and the return contact is located on a stimulator body of the stimulator, and wherein the stimulator probe is reversibly attachable to the stimulator body.2. The method of claim 1 , further comprising delivering current from the first electrode through tissue of the patient to a second electrode claim 1 , wherein the second electrode is located on the nasal insertion prong.3. The method of claim 2 , wherein current is delivered simultaneously from the first electrode to the return contact and from the first electrode to the second electrode.4. The method of claim 2 , wherein current is delivered sequentially from the first electrode to the return contact and from the first electrode to the second electrode.5. The method of claim 1 , wherein the first electrode contacts nasal mucosa in the anterior nasal cavity.6. The method of claim 5 , wherein the first electrode contacts nasal mucosa at a location anterior to a middle or inferior turbinate of the nasal cavity.7. The method of claim 2 , wherein the ...

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Номер записи: 37
17-04-2014 дата публикации

USER INTERFACE WITH 3D ENVIRONMENT FOR CONFIGURING STIMULATION THERAPY

Номер: US20140107731A1
Автор: Ball Warren W., Goetz Steven M., Otten Lynn M., Stone Richard T., Wahlstrand Carl D.
Принадлежит: Medtronic, Inc.

The disclosure describes a method and system that allows a user to configure electrical stimulation therapy by defining a three-dimensional (3D) stimulation field. After a stimulation lead is implanted in a patient, a clinician manipulates the 3D stimulation field in a 3D environment to encompass desired anatomical regions of the patient. In this manner, the clinician determines which anatomical regions to stimulate, and the system generates the necessary stimulation parameters. In some cases, a lead icon representing the implanted lead is displayed to show the clinician where the lead is relative to the 3D anatomical regions of the patient. 1. A method comprising:representing a three-dimensional (3D) anatomical region of a patient in a 3D environment;representing a 3D stimulation field within the 3D anatomical region;receiving stimulation field input from a user defining the 3D stimulation field in the 3D environment; andgenerating electrical stimulation parameters in a programming device based upon the 3D stimulation field and a location of at least one electrode within patient.2. The method of claim 1 , wherein the electrical stimulation parameters define an electrode combination from a complex electrode array geometry.3. The method of claim 1 , further comprising:representing an electrical stimulation lead as a lead icon in the 3D environment; andpositioning the lead icon relative to the 3D anatomical region of the patient in the 3D environment based on a physical location of the electrical stimulation lead in the patient.4. The method of claim 3 , wherein positioning the lead icon comprises receiving directional user input specifying placement of the lead icon relative to the 3D anatomical region of the patient.5. The method of claim 3 , wherein positioning the lead icon comprises:receiving information regarding the physical location of the electrical stimulation lead in the patient; andautomatically positioning the lead icon relative to the 3D anatomical ...

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Номер записи: 38
23-01-2020 дата публикации

AUTOMATIC ADJUSTMENT TO MAINTAIN EVOKED POTENTIAL FEATURE

Номер: US20200023188A1
Автор: Bradley Kerry, Haut Harold, Nathan Robert, Peterson David K.L., Thacker James R.
Принадлежит:

Tissue stimulation systems generally include a pulse generating device for generating electrical stimulation pulses, at least one implanted electrode for delivering the electrical stimulation pulses generated by the pulse generating device, and a programmer capable of communicating with the pulse generating device. Stimulation pulses may be defined by several parameters, such as pulse width and amplitude. In methods of stimulating the tissue with the stimulation system, a user may adjust one of the parameters such as pulse width. The programmer may automatically adjust the pulse amplitude in response to the change in pulse width in order to maintain a substantially constant effect of the stimulation pulses. 1. (canceled)2. A method , comprising:delivering electrical current defined by adjustable stimulation parameters to at least one electrode to provide at least one evoked potential feature, wherein the adjustable stimulation parameters have a defined relationship to the at least one evoked potential feature and include at least a first stimulation parameter and a second stimulation parameter; andadjusting at least the first stimulation parameter, and then maintaining the at least one evoked potential feature by automatically adjusting at least the second stimulation parameter, using the defined relationship, in response to adjusting the at the first stimulation parameter.3. The method of claim 2 , wherein the at least one evoked potential feature includes an evoked potential amplitude.4. The method of claim 2 , wherein the at least one evoked potential feature includes an evoked potential conduction velocity.5. The method of claim 2 , wherein:the defined relationship includes a defined relationship of a pulse rise time, a pulse fall time, and a pulse amplitude to the at least one evoked potential feature,the first stimulation parameter includes the pulse amplitude, andthe at least the second parameter includes at least one of the pulse rise time or the pulse fall ...

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Номер записи: 39
02-02-2017 дата публикации

DELAYING THE ONSET OF MUSCLE FATIGUE ASSOCIATED WITH FUNCTIONAL ELECTRICAL STIMULATION

Номер: US20170028210A1
Автор: Fisher Lee, Triolo Ronald, Tyler Dustin J.
Принадлежит:

The present invention relates a system that can configure a stimulus for functional electrical stimulation (“FES”) to maintain a constant muscle force while delaying the onset of muscle fatigue and a related method of use. The stimulus can be delivered to a nerve via a set of multiple electrode contacts according to a stimulation parameter that maximizes a joint moment associated with the stimulus and minimizes the overlap between pairs of contacts. The joint moment can be related to the muscle force, and the overlap can be related to the onset of muscle fatigue. 120-. (canceled)21. A method comprising:configuring, by a system comprising a processor, a set of electrical stimulation waveforms to be applied to a nerve by a set of electrode contacts, wherein the configuring comprises determining a set of stimulation parameters to maximize joint moment and minimize overlap between pairs of contacts in the set of electrode contacts; andapplying the set of electrical stimulation waveforms to the nerve according to the stimulation parameter.22. The method of claim 21 , wherein the set of stimulation parameters is determined based on an optimization of a cost function based on a first model of joint moment and a second model of overlap between contacts recruiting the same motor unit.23. The method of claim 22 , wherein the first model of the joint moment is based on a sum of moments generated based on the electrical stimulation waveform from the set of electrical stimulation waveforms delivered by each contact of the set of multiple electrode contacts.24. The method of claim 23 , wherein the sum of moments corresponds to a sum of twitch responses of the muscle to the electrical stimulation waveform from the set of electrical stimulation waveforms delivered by each contact of the set of electrode contacts.25. The method of claim 22 , wherein the set of stimulation parameters is determined by minimizing the cost function.26. The method of claim 21 , wherein application of the ...

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Номер записи: 40
01-02-2018 дата публикации

SYSTEMS AND METHODS FOR SELECTIVE MEMORY ENHANCEMENT AND/OR DISRUPTION

Номер: US20180028813A1
Автор: Brincat Scott L., Miller Earl K.
Принадлежит:

Systems and methods are disclosed for selectively reinforcing or weakening memory associations. At least one current generator provides an electrical current including a plurality of oscillating pulses with at least one predetermined frequency. A user interface includes at least one output device for delivering a sensory stimulus to a user and at least one user input device for registering a response to the stimulus. At least one processor determines from the response, based on at least one predetermined standard, whether an underlying memory association is desired or undesired and respectively sets the at least one predetermined frequency to be a beta or theta frequency. Consequently, the electrical current is generated and administered, via at least one electrode pair, thereby stimulating at least one specific portion of the user's brain so as to reinforce or weaken the underlying memory association. 1. A system for selectively reinforcing or weakening memory associations , the system comprising:at least one current generator for providing an electrical current, the electrical current including a plurality of oscillating pulses with at least one predetermined frequency; at least one output device for delivering at least one sensory stimulus to a user;', 'at least one user input device for registering at least one response of the user to the at least one sensory stimulus; and', "at least one electrode pair for detachable attachment to or proximate to the user's scalp, the at least one electrode pair configured to stimulate at least one specific portion of the user's brain with the electrical current based at least in part on the at least one response of the user to the at least one sensory stimulus;"], 'a user interface, includingat least one memory for storing processor-executable instructions; and controls the user interface to deliver a first sensory stimulus to the user and register the at least one response of the user to the first sensory stimulus;', ' ...

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Номер записи: 41
01-02-2018 дата публикации

VAGUS NERVE AND CAROTID BARORECEPTOR STIMULATION SYSTEM

Номер: US20180028817A1
Автор: Amurthur Badri, KenKnight Bruce H., Libbus Imad
Принадлежит: CYBERONICS, INC.

Systems and methods are provided for delivering vagus nerve stimulation and carotid baroreceptor stimulation to patients for treating chronic heart failure and hypertension. The vagus nerve stimulation and carotid baroreceptor stimulation therapies may be provided using a single implantable pulse generator, which can coordinate delivery of the therapies. 1. A method of operating an implantable neurostimulation system , comprising:delivering a vagus nerve stimulation (VNS) therapy to a vagus nerve of a patient, according to a first set of parameters, with a VNS subsystem of a pulse generator; anddelivering a carotid baroreceptor stimulation (CBS) therapy to carotid baroreceptors of the patient, according to a second set of parameters different from the first set of parameters, with a CBS subsystem of the pulse generator.2. The method according to claim 1 , further comprising:detecting subcutaneous electrocardiographic (ECG) signals; anddetermining, based on the ECG signals, a change in a heart rate in response to at least one of the VNS therapy or the CBS therapy.3. The method according to claim 1 , further comprising:estimating when the patient is in a sleep state; andmodifying at least one of the first set of parameters of the VNS therapy or the second set of parameters of the CBS therapy when the patient is estimated to be in a sleep state.4. The method according to claim 1 , further comprising:determining an activity level of the patient; andmodifying at least one of the first set of parameters of the VNS therapy or the second set of parameters of the CBS therapy based on the determined activity level.5. The method according to claim 1 , wherein:delivering the VNS therapy comprises delivering the VNS therapy via a VNS electrode assembly coupled to the vagus nerve; anddelivering the CBS therapy comprises delivering the CBS therapy via a CBS electrode assembly electrically coupled to the carotid baroreceptors.6. The method according to claim 5 , wherein the VNS ...

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Номер записи: 42
17-02-2022 дата публикации

DEVICE NETWORKS FOR MODULATING NEURAL ACTIVITY

Номер: US20220047869A1
Автор: Carmena Jose M., Maharbiz Michel M., Neely Ryan
Принадлежит: Iota Biosciences, Inc.

Described herein are implantable device networks that include two or implantable devices configured to modulate neural activity in a subject. The network includes at least one implantable device that can detect a detection signal, such as an electrophysiological signal or a physiological condition. The network also includes a second implantable device configured to emit an electrical pulse based at least on information related to the detection signal. The implantable devices in the network can wirelessly communicate between each other, either directly or through an intermediate device. 1. A method of modulating neural activity using an implantable device network , comprising:(a) detecting, at one or more implantable devices in a first set of one or more implantable devices, a detection signal comprising one or more electrophysiological signals transmitted by a recorded nerve or one or more physiological conditions;(b) wirelessly transmitting, from the one or more implantable devices in the first set of one or more implantable devices, information related to the detection signal;(c) wirelessly receiving, at one or more implantable devices in a second set of one or more implantable devices, the information related to the detection signal; and(d) determining whether to emit, from one or more implantable devices in the second set of one or more implantable devices, one or more electrical pulses configured to modulate neural activity of one or more target nerves based on at least the received information related to the detection signal.2. The method of claim 1 , comprising emitting claim 1 , at the one or more implantable devices in the second set of one or more implantable devices claim 1 , the one or more electrical pulses.3. The method of claim 2 , comprising determining one or more pulse characteristics of the one or more electrical pulses emitted from the one or more implantable devices in the second set of one or more implantable devices in the second set of one or ...

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Номер записи: 43
04-02-2021 дата публикации

STIMULATION DEVICES AND METHODS FOR TREATING DRY EYE

Номер: US20210031040A1
Автор: FRANKE Manfred, HOLDBROOK Mark Jeffrey, LOUDIN James Donald, WARDLE John
Принадлежит:

Described herein are devices and methods of use thereof for treating dry eye, tired eye, or other forms of ocular discomfort such as from contact lenses. The methods generally include applying spatially and/or temporally patterned stimulation to one or more anatomical structures located in an ocular or nasal region. The electrical stimulation may elicit a reflex that activates the lacrimal gland or may directly activate the lacrimal gland or nerves innervating the lacrimal gland to produce tears. The devices may be implantable or handheld, and may be configured to deliver the spatially and/or temporally patterned stimulation patterns described. 120.-. (canceled)21. A device for delivering an electrical stimulus to nasal mucosa of a patient , comprising:a stimulator probe comprising a first nasal insertion prong including a first electrode configured to deliver current, the stimulator probe further comprising a second electrode;a stimulator body comprising a power source and configured to releasably couple the stimulator probe to the stimulator body, the stimulator body being configured to be held by the patient while delivering current from the first electrode, the stimulator body comprising a return contact positioned to contact tissue of the patient while the patient is holding the stimulator body, the return contact configured to receive at least a portion of the delivered current.22. The device of claim 21 , further comprising a user interface configured to allow the patient to adjust an amount of current delivered between the first electrode and the second electrode and between the first electrode and the return contact.23. The device of claim 22 , wherein the user interface comprises one or more operating mechanisms configured to adjust one or more parameters of the delivered current.24. The device of claim 21 , wherein the current is configured to be delivered between the first electrode and the return contact through tissue of the patient.25. The device of ...

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Номер записи: 44
09-02-2017 дата публикации

SYSTEMS AND METHODS FOR RESTORING MUSCLE FUNCTION TO THE LUMBAR SPINE

Номер: US20170036025A1
Автор: CROSBY Peter Andrew, Rawat Prashant Brijmohansingh, Sachs Dan, SHIROFF Jason Alan
Принадлежит: Mainstay Medical Limited

A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters. 1. A system for restoring muscle function to the lumbar spine to treat back pain , the system comprising:one or more electrodes configured to be implanted in or adjacent to tissue associated with control of the lumbar spine;a pulse generator operatively coupled to the one or more electrodes, the pulse generator configured to deliver a neuromuscular electrical stimulation therapy for restoring muscle function to the lumbar spine to treat back pain via the one or more electrodes; anda computer readable medium with instructions that, when executed by a processor of a computer operatively coupled to the pulse generator, cause a graphical user interface displayed on the computer to generate at least one user interface screen configured to display to the user information retrieved from the pulse generator, an identification and status area, an electrode configuration area, and a sessions parameters area.2. The system of claim 1 , wherein the system is configured to communicate with the pulse generator via an external programmer.3. The system of claim 1 , wherein the identification and status area is configured to permit the user to enter an ID for a subject having the pulse generator implanted therein claim 1 , and to activate and deactivate operation of the pulse generator claim 1 , the identification and status area further configured to display remaining battery ...

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Номер записи: 45
09-02-2017 дата публикации

MULTI-CHANNEL NEUROMODULATION SYSTEM HAVING FREQUENCY MODULATION STIMULATION

Номер: US20170036030A1
Автор: Doan Que T., Zhu Changfang
Принадлежит:

A neuromodulation system comprises a plurality of electrical terminals configured for being respectively coupled to electrodes, modulation output circuitry configured for respectively outputting a plurality of individual electrical pulse trains in a plurality of timing channels to the electrical terminals, wherein each of the timing channels prevents the respective pulse train from having a specific characteristic, and control circuitry configured for controlling the modulation output circuitry in a manner that outputs the pulse trains to a common set of the electrical terminals, thereby creating a combined electrical pulse train at the common set of electrical terminals that has the specific characteristic. A method of providing therapy to a patient comprises delivering a plurality of electrical pulse trains respectively in a plurality of timing channels to a common set of electrodes implanted within the patient, thereby creating a combined electrical pulse train at the common set of electrical terminals. 1. (canceled)2. A neuromodulation system to deliver neuromodulation therapy using a patterned electrical waveform output through an electrode , comprising:an electrical terminal configured to be electrically coupled to the electrode;modulation output circuitry configured to output patterned electrical signals in timing channels to the electrical terminal; andcontrol circuitry configured to control the modulation output circuitry to combine the patterned electrical signals at the electrical terminal to provide the patterned electrical waveform, wherein the patterned electrical signals have characteristics that provide the patterned electrical waveform.3. The neuromodulation system of claim 2 , wherein the patterned electrical signals have amplitudes claim 2 , and the control circuitry is further configured to combine the patterned electrical signals to sum the amplitudes at the electrical terminal to provide the patterned electrical waveform.4. The neuromodulation ...

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Номер записи: 46
24-02-2022 дата публикации

Device and Implantation System for Electrical Stimulation of Biological Systems

Номер: US20220054834A1
Автор: Gani Matt Joseph, Goode Paul V., Hogg Bevil, Miazga Jay, Policker Shai, Raby Kaila, Sharma Virender K.
Принадлежит:

The present specification discloses devices and methodologies for the treatment of transient lower esophageal sphincter relaxations (tLESRs). Individuals with tLESRs may be treated by implanting a stimulation device within the patient's lower esophageal sphincter and applying electrical stimulation to the patient's lower esophageal sphincter, in accordance with certain predefined protocols. The presently disclosed devices have a simplified design because they do not require sensing systems capable of sensing when a person is engaged in a wet swallow and have improved energy storage requirements. 1. A method of implanting electrodes in a patient in order to treat gastroesophageal reflux disease , comprising:implanting a first electrode in an anterior proximal wall of an esophagus, wherein said first electrode is positioned axially along a length of said esophagus; andimplanting a second electrode proximate a right lateral wall of said esophagus, wherein said second electrode is positioned parallel and distal to said first electrode.2. The method of claim 1 , further comprising the steps of:connecting said first and second electrodes to a pulse stimulator configured to supply a stimulation pulse to said first and second electrodes; andoperating said first and second electrodes in combination to deliver electrical stimulation to at least partly normalize a function of a lower esophageal sphincter (LES) of said patient post-stimulation.3. The method of claim 2 , wherein said stimulation pulse has a pulse amplitude equal to or less than 15 mAmp.4. The method of claim 2 , wherein said pulse stimulator is configured to detect a LES pressure derived from an impedance sensor claim 2 , piezoelectric sensor claim 2 , or electrical activity based sensor.5. The method of claim 1 , wherein said second electrode is separated from said first electrode by a distance equal to or less than 1.5 cm.6. The method of claim 1 , wherein said first electrode and second electrode are each ...

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Номер записи: 47
06-02-2020 дата публикации

ORAL APPLIANCE AND KIT FOR TREATMENT OF SLEEP APNEA

Номер: US20200038231A1
Автор: Radmand Reza
Принадлежит: Achaemenid, LLC

An oral appliance for the treatment of obstructive sleep apnea includes a mouthpiece configured for being received in an oral cavity of a user. The mouthpiece may include a pulse oximeter, a pressure sensor, an airflow sensor, an actigraphy sensor, a noise detector, and at least one stimulator for providing stimulation to a user's tongue in the event of decreased oxygen saturation levels, increased pressure applied to occlusal surfaces of the user's dentition, decreased actual airflow levels and/or increased noise levels. A microprocessor receives data from the oxygen sensor, pressure sensor, airflow sensor, actigraphy sensor and noise detector, and activates the at least one stimulator. 1. An oral appliance for treatment of sleep apnea in a user , comprising:a mouthpiece for being received in an oral cavity of the user;at least one pulse oximeter attached to the mouthpiece, wherein the pulse oximeter is configured to monitor actual oxygen saturation levels of hemoglobin of the user; andat least one stimulator attached to the mouthpiece and configured for providing stimulation to the user in response to the actual oxygen saturation level of hemoglobin of the user.2. The oral appliance of claim 1 , wherein the stimulator provides constant stimulation or variant stimulation to a genioglossus muscle of the user's tongue until the oxygen saturation level of hemoglobin rises above the predetermined level.3. The oral appliance of claim 1 , wherein the stimulator is activated if the at least one pulse oximeter determines that the actual oxygen saturation level of hemoglobin of the user is below about 95% oxygen saturation.4. The oral appliance of claim 1 , further comprising one or more pressures sensors positioned at an occlusal portion of the mouthpiece and configured for measuring actual pressure applied to the mouthpiece.5. The oral appliance of claim 1 , further comprising a noise detector attached to the mouthpiece claim 1 , wherein the noise detector is configured ...

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Номер записи: 48
12-02-2015 дата публикации

METHOD AND DEVICE FOR DISPLAYING PREDICTED VOLUME OF INFLUENCE

Номер: US20150045852A1
Автор: BUTSON Christopher R., Hall John D., Henderson Jaimie M., MCINTYRE Cameron C.
Принадлежит:

This document discusses, among other things, brain stimulation models, systems, devices, and methods, such as for deep brain stimulation (DBS) or other electrical stimulation. In an example, volumetric imaging data representing an anatomical volume of a brain of a patient can be obtained and transformed to brain atlas data. A patient-specific brain atlas can be created using the inverse of the transformation to map the brain atlas data onto the volumetric imaging data and a volume of influence can be calculated using the patient-specific brain atlas. In certain examples, the volume of influence can include a predicted volume of tissue affected by an electrical stimulation delivered by an electrode at a corresponding at least one candidate electrode target location. 126-. (canceled)27. A computer-implemented method of outputting information concerning an electrode inserted inside a patient's neural tissue , the method comprising:determining, by a computer processor, a distribution of electrical values, to be generated by the inserted electrode, in the patient's neural tissue in a region surrounding the inserted electrode;determining at least one threshold electrical value for neural tissue activation;determining, by the processor and by applying the at least one threshold value to the electrical values, an estimated volume of neural tissue activated by the distribution of electrical values; andoutputting, by the processor, a graphical representation of the determined estimated volume.28. The method of claim 27 , wherein the outputting includes displaying the graphical representation relative to an anatomical atlas.29. The method of claim 27 , further comprising determining conductivity at a plurality of tissue regions claim 27 , wherein the determination of the distribution of electrical values is based on the determined conductivity.30. The method of claim 29 , wherein the plurality of tissue regions span an anatomical area across which the determined conductivity ...

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Номер записи: 49
18-02-2016 дата публикации

VAGUS NERVE AND CAROTID BARORECEPTOR STIMULATION SYSTEM

Номер: US20160045741A1
Автор: Amurthur Badri, KenKnight Bruce H., Libbus Imad
Принадлежит:

Systems and methods are provided for delivering vagus nerve stimulation and carotid baroreceptor stimulation to patients for treating chronic heart failure and hypertension. The vagus nerve stimulation and carotid baroreceptor stimulation therapies may be provided using a single implantable pulse generator, which can coordinate delivery of the therapies. 1. An implantable neurostimulation system , comprising:a pulse generation module comprising a control system, a vagus nerve stimulation (VNS) subsystem, and an implantable carotid baroreceptor stimulation (CBS) subsystem;a first VNS electrode assembly coupled to the pulse generation module, said first VNS electrode assembly configured to couple to and deliver electrical stimulation to a vagus nerve; anda first CBS electrode assembly coupled to the pulse generation module, said first CBS electrode assembly configured to couple to and deliver electrical stimulation to carotid baroreceptors.2. The system according to claim 1 , wherein:the control system is configured to activate the VNS subsystem to deliver electrical energy to the first VNS electrode assembly and to activate the CBS subsystem to deliver electrical energy to the first CBS electrode assembly.3. The system according to claim 1 , further comprising:a first lead assembly coupled to the pulse generation module, said first lead assembly comprising the first VNS electrode assembly and the first CBS electrode assembly.4. The system according to claim 3 , wherein:the first lead assembly comprises a bifurcated portion coupled to a first VNS lead portion and a first CBS lead portion, wherein the first VNS electrode assembly is provided at a distal end of the first VNS lead portion and the first CBS electrode assembly is provided at a distal end of the first CBS lead portion.5. The system according to claim 3 , wherein:the first lead assembly comprises a cuff portion configured to wrap around both the vagus nerve and a carotid artery, said first VNS electrode ...

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Номер записи: 50
18-02-2016 дата публикации

ELECTRICAL CHARGE BALANCING METHOD FOR FUNCTIONAL STIMULATION USING PRECISION PULSE WIDTH COMPENSATION

Номер: US20160045743A1
Автор: Chen Kuanfu, Hill Richard, Liu Wentai, Lo Yi-Kai
Принадлежит: The Regents of the University of California

An apparatus and method for electrical charge balancing when generating a stimulus during functional neural stimulation is presented. A stimulus pulse is generated (cathodic or anodic), and after a selected delay a charge compensating pulse is generated of an opposite polarity. The electrode circuit discontinuously examines electrode voltage after termination of the stimulus pulse, and utilizes this voltage to determine how long to extend the width of the charge compensating pulse. The electrode circuit thus performs accurate electrical charge cancellation to remove residual charges from the electrode by precisely controlling pulse width for an opposing polarity compensating pulse that need not have the same current level as the stimulus pulse. 1. An apparatus for electrical charge balancing when generating functional neural stimulation , comprising:one or more stimulus electrodes;a stimulation pulse generation circuit configured for driving current waveforms as a cathodic or anodic stimulus through said one or more stimulation electrodes;a switching circuit configured for sampling electrode voltage from each said stimulus electrode when each stimulus terminates;a feedback sensor coupled to said switching circuit for generating triggering signals in response to comparing electrode voltage sampled by said switching circuit with a reference; anda digital control circuit configured for causing said stimulation pulse generation circuit to output either a cathodic or anodic stimulus pulse, then after a selected delay, causing said stimulation pulse generation circuit to generate an opposing polarity pulse having a pulse width that is adjusted by said digital control circuit toward achieving a zero net charge residual based on input from said trigger signals.2. The apparatus recited in claim 1 , wherein said one or more stimulus electrodes comprises an array of electrodes.3. The apparatus recited in claim 1 , wherein said switching circuit is configured for turning on and ...

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Номер записи: 51
16-02-2017 дата публикации

Head pain management device having an antenna

Номер: US20170043165A1
Автор: Adi Mashiach, Carsten Mueller
Принадлежит: Adi Mashiach, Carsten Mueller

A device may include a primary antenna configured to be located external to a subject and at least one processor in electrical communication with the primary antenna. The at least one processor may be configured to cause transmission of a primary signal from the primary antenna to an implantable device, wherein the implantable device includes at least one pair of modulation electrodes. The at least one processor may be further configured to adjust one or more characteristics of the primary signal to generate a sub-modulation control signal adapted so as not to cause a neuromuscular modulation inducing current at the at least one pair of modulation electrodes when received by the implantable device and to generate a modulation control signal adapted so as to cause a neuromuscular modulation inducing current at the at least one pair of modulation electrodes when received by the implantable device.

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Номер записи: 52
16-02-2017 дата публикации

Controlling Charge Flow in the Electrical Stimulation of Tissue

Номер: US20170043169A1
Автор: Jordi Parramon, Kelly H. Mcclure, Rafael Carbunaru
Принадлежит: Boston Scientific Neuromodulation Corp

Systems of techniques for controlling charge flow during the electrical stimulation of tissue. In one aspect, a method includes receiving a charge setting describing an amount of charge that is to flow during a stimulation pulse that electrically stimulates a tissue, and generating and delivering the stimulation pulse in a manner such that an amount of charge delivered to the tissue during the stimulation pulse accords with the charge setting.

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Номер записи: 53
16-02-2017 дата публикации

User interface with 3d environment for configuring stimulation therapy

Номер: US20170043172A1
Автор: Carl D. Wahlstrand, Lynn M. Otten, Richard T. Stone, Steven M. Goetz, Warren W. Ball
Принадлежит: MEDTRONIC INC

The disclosure describes a method and system that allows a user to configure electrical stimulation therapy by defining a three-dimensional (3D) stimulation field. After a stimulation lead is implanted in a patient, a clinician manipulates the 3D stimulation field in a 3D environment to encompass desired anatomical regions of the patient. In this manner, the clinician determines which anatomical regions to stimulate, and the system generates the necessary stimulation parameters. In some cases, a lead icon representing the implanted lead is displayed to show the clinician where the lead is relative to the 3D anatomical regions of the patient.

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Номер записи: 54
15-02-2018 дата публикации

PROGRAMMABLE AUTOTITRATING OF ELECTRICAL PARAMETERS OF IMPLANTABLE MEDICAL DEVICE

Номер: US20180043165A1
Автор: Osorio Ivan
Принадлежит: FLINT HILLS SCIENTIFIC, L.L.C.

We report a method of automatically titrating an electrical therapy administered to a patient by an implanted medical device to a target dosage, comprising programming the medical device with a programmed electrical therapy comprising a first target value for a first therapy parameter; programming at least one titration parameter for automatically adjusting the first therapy parameter from a first value to the first target value over a titration time period initiating the electrical therapy, wherein the first therapy parameter comprises said first value; and automatically titrating the electrical therapy by making a plurality of adjustments to the value of the first therapy parameter, whereby the first electrical therapy parameter is changed from the first value to the first target value according to a titration function. We also report a medical device system configured to implement the method. 1. A method of treating a medical condition of a patient via an implantable medical device comprising:initiating via one or more processors of the implantable medical device a titration period for a first therapy with a first treatment period based on an input obtained from the patient, the first therapy including an electrical stimulation with one or more parameters;initiating a modification procedure of one or more values associated with the one or more parameters during the titration period; andinitiating the first therapy for the first treatment period based on one or more parameters being tolerated by the patient or reaching one or more target values.2. The method of claim 1 , further comprising initiating a second titration period for a second therapy with a second treatment period.3. The method of claim 2 , further comprising initiating a third therapy based on an acute event detection.4. The method of claim 1 , further comprising initiating a third therapy based on an acute event detection.5. The method of claim 1 , wherein one or more changes in the one or more ...

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Номер записи: 55
03-03-2022 дата публикации

MODULATING AFFERENT SIGNALS TO TREAT MEDICAL CONDITIONS

Номер: US20220062637A1
Автор: Johnson Bruce D., Joyner Michael J., Olson Thomas P.
Принадлежит: Mayo Foundation for Medical Education and Research

This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided.

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Номер записи: 56
19-02-2015 дата публикации

SELECTIVE RECRUITMENT AND ACTIVATION OF FIBER TYPES IN NERVES FOR THE CONTROL OF UNDESIRABLE BRAIN STATE CHANGES

Номер: US20150051637A1
Автор: Osorio Ivan
Принадлежит:

We disclose methods and medical device systems for selectively recruiting a nerve fiber type within a cranial nerve, a peripheral nerve or a spinal root. Such a method may comprise applying a first pressure, a heating, and/or a cooling to a second location of the nerve, the pressure, heating, or cooling sufficient to substantially block at least one of activation or conduction in at least one fiber population through the second location of the nerve for a blocking time period; and applying an electrical signal to a first location during the blocking time period. 1. A method for selectively recruiting a nerve fiber type of a cranial nerve , a peripheral nerve or a spinal root , comprising:performing an operation selected from one of heating or cooling a second location of said cranial nerve, said peripheral nerve or said spinal root, said heating or cooling sufficient to substantially block at least one of activation or conduction on at least a first fiber type of said cranial nerve, said peripheral nerve or said spinal root for a blocking time period; andapplying an electrical signal to a first location of cranial nerve, said peripheral nerve or said spinal root during said blocking time period.2. The method of further comprising selecting at least a second fiber type of said cranial nerve claim 1 , said peripheral nerve or said spinal root for stimulation by said electrical signal claim 1 , wherein said at least a second fiber type is different from said at least a first fiber type.3. The method of claim 1 , wherein the at least a first fiber type population is selected from an A-fiber population claim 1 , a B-fiber population claim 1 , or a C-fiber population.4. The method of claim 1 , wherein said heating or cooling comprises heating or cooling said cranial nerve claim 1 , said peripheral nerve or said spinal root to a selected temperature at said second location claim 1 , and wherein said temperature is programmably selectable.5. The method of claim 1 , further ...

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Номер записи: 57
25-02-2021 дата публикации

IMPLANTABLE NEURO-STIMULATION DEVICE

Номер: US20210052898A1
Автор: Cameron Tracy, Mantes Ernest, Robinson David
Принадлежит: Mudjala Medical Pty Limited

An implantable electrical stimulation device includes an electrically conductive electrode structure configured for coupling with a pulse generator device and transmitting an electrical signal configured to generate a desirable electric field around a target tissue. The electrode structure includes a porous substrate constructed of a bio-compatible and bio-survivable material having a structure that mimics extracellular matrix embedding. The porous substrate supports an electrically conductive electrode element. The implantable device may further include a pulse generator also embedded, enmeshed, and supported within the porous substrate. 1. (canceled)2. A method of neural stimulation for therapeutic outcomes comprising:generating a first stimulation pattern with a first desired therapeutic outcome;generating a second stimulation pattern with a second desired therapeutic outcomecombining the first and second stimulation patterns to produce a composite stimulation pattern with an enhanced therapeutic outcome; andtransmitting the composite stimulation pattern to an implanted lead assembly disposed proximate to a target nerve.3. The method of claim 2 , further comprising generating at least one additional stimulation pattern to achieve at least one additional enhanced therapeutic outcome and combining said at least one additional stimulation pattern with the first and second stimulation patterns to produce the composite stimulation pattern with an enhanced therapeutic outcome.4. The method of claim 2 , further comprising independently adjusting parameters of at least one of the first and second stimulation patterns.5. The method of claim 4 , wherein generating the first stimulation pattern comprises adjusting at least one of frequency and amplitude to achieve the first desired therapeutic outcome.6. The method of claim 4 , wherein generating the second stimulation pattern comprises adjusting at least one of frequency and amplitude to achieve the second desired ...

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Номер записи: 58
13-02-2020 дата публикации

SYSTEMS AND METHODS FOR RESTORING MUSCLE FUNCTION TO THE LUMBAR SPINE AND KITS FOR IMPLANTING THE SAME

Номер: US20200046972A1
Автор: Beck John, CROSBY Peter, DEMORETT Henry, SHIROFF Jason Alan, SKUBITZ Jason
Принадлежит: Mainstay Medical Limited

A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include one or more electrode leads coupled to an implantable pulse generator (IPG) and a tunneler system for subcutaneously implanting a proximal portion of the lead(s). The system may also include a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters. 1. A kit for use in implanting components for restoring muscle function of the lumbar spine , the kit comprising:an electrode lead configured to be implanted in or adjacent to tissue associated with control of the lumbar spine, the electrode lead having a proximal end and a distal end with one or more electrodes disposed thereon;a pulse generator configured to be coupled to the proximal end of the electrode lead, the pulse generator having a programmable controller configured to provide electrical stimulation via the one or more electrodes disposed on the electrode lead;a tunneler comprising an elongated shaft, a proximal end having a handle, a stopper positioned between the elongated shaft and the handle, and a threaded portion at a distal end of the elongated shaft;a tunneler tip having a mating portion configured to be removably coupled to the threaded portion of the tunneler, the tunneler tip configured to create a subcutaneous passage; anda sheath having a lumen extending therethrough configured to receive the elongated body of the tunneler including the threaded portion and the proximal end of the electrode lead, the sheath sized and shaped to fit between the stopper and the threaded portion of the tunneler, the sheath further ...

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Номер записи: 59
13-02-2020 дата публикации

Varying Stimulation Parameters to Prevent Tissue Habituation in a Spinal Cord Stimulation System

Номер: US20200046980A1
Автор: Ismael HUERTAS FERNANDEZ, Michael A. Moffitt
Принадлежит: Boston Scientific Neuromodulation Corp

A method is disclosed for programming a patient's stimulator device using an external device. The method obtains information such as a model at the external device, wherein the information is specific to the patient, wherein the information comprises a range or volume of stimulation parameters determined based on testing of the patient that preferably provide sub-perception therapy; and providing from the external device instructions for execution at the stimulator device, the instructions specifying an amplitude, a pulse width, and a frequency of stimulation pulses to be provided at one of more of electrodes in an electrode array of the patient's stimulator device, wherein the instructions vary over time at least one of the amplitude, pulse width, and frequency within the range or volume. Varying at least one of these parameters helps in preventing the patient's neural tissue from become habituated when compared to stimulation that is provided without variance.

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Номер записи: 60
22-02-2018 дата публикации

FULLY IMPLANTABLE MODULAR COCHLEAR IMPLANT SYSTEM

Номер: US20180050198A1
Автор: Earnest Timothy J., MAZANEC PAUL R., Whittington Benjamin R.
Принадлежит:

Cochlear implant systems can include a cochlear electrode, a stimulator in electrical communication with the cochlear electrode, and a signal processor in communication with the stimulator. The signal processor can receive an input signal from an input source and output a stimulation signal to the stimulator based on the received input signal and a transfer function of the signal processor. The signal processor can be connected to the stimulator via a first detachable connector configured to detachably connect and provide communication between the signal processor and the stimulator. The signal processor can be connected to the input source via a second detachable connector configured to detachably connect and provide communication between the signal processor and the input source. A modular signal processor can be detached from the stimulator and the input source for repair or replacement. 1. A modular cochlear implant system comprising:a cochlear electrode;a stimulator in electrical communication with the cochlear electrode;a signal processor in communication with the stimulator;an input source in communication with the signal processor; anda first detachable connector configured to detachably connect the signal processor and the stimulator and to provide communication between the signal processor and the stimulator when attached; whereinthe signal processor is configured to receive an input signal from the input source and output a stimulation signal to the stimulator based on the received input signal and a transfer function of the signal processor;the stimulator provides an electrical stimulus to the cochlear electrode based on the stimulation signal; andthe cochlear electrode, the stimulator, the signal processor, and the input source are fully implantable into a patient.2. The implant system of claim 1 , further comprising a second detachable connector configured to detachably connect the signal processor and the input source and to provide communication ...

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Номер записи: 61
26-02-2015 дата публикации

MODULATING AFFERENT SIGNALS TO TREAT MEDICAL CONDITIONS

Номер: US20150057313A1
Автор: Johnson Bruce D., Joyner Michael J., Olson Thomas P.
Принадлежит:

This document provides methods and materials for modulating afferent nerve signals to treat medical conditions such as CHF, CHF respiration, dyspnea, peripheral vascular disease (e.g., peripheral arterial disease or venous insufficiency), hypertension (e.g., age-associated hypertension, resistant hypertension, or chronic refractory hypertension), COPD, sleep apnea, and chronic forms of lung disease where muscle dysfunction is a part of the disease pathophysiology. For example, methods and materials involved in using electrical and/or chemical techniques to block or reduce afferent nerve signals (e.g., nerve signals of group III and/or IV afferents coming from skeletal muscle and/or the kidneys) are provided. 1. A method for increasing exercise tolerance of a mammal having heart failure , wherein said method comprises:(a) identifying a mammal having heart failure and reduced exercise tolerance, and(b) applying an electrical therapy signal to a muscle or kidney afferent nerve of said mammal under conditions wherein afferent nerve signals of said muscle or kidney afferent nerve are reduced or blocked.2. The method of claim 1 , wherein said mammal is a human.3. The method of claim 1 , wherein said method comprises implanting an electrode device within said mammal.4. The method of claim 1 , wherein said electrical therapy signal comprises a frequency between about 1 and about 100 Hz claim 1 , a current intensity between about 1 and about 10 μA claim 1 , and a pulse width of about 1 to about 10 milliseconds.5. The method of claim 1 , wherein said method comprises applying said electrical therapy signal to a muscle afferent nerve.67-. (canceled)8. The method of claim 1 , wherein said method comprises applying said electrical therapy signal to a kidney afferent nerve.910-. (canceled)11. The method of claim 1 , wherein said electrical therapy signal is delivered by an electrode connected to an implanted neurostimulator control unit.12. The method of claim 1 , wherein said ...

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Номер записи: 62
04-03-2021 дата публикации

SUBTHRESHOLD DIRECT CURRENT (DC) NERVE CONDUCTION BLOCK AFTER SUPRATHRESHOLD "PRIMING"

Номер: US20210060344A1
Автор: BHADRA Niloy, Kilgore Kevin L., SHAW Laura, VRABEC Tina L.
Принадлежит:

A DC nerve conduction block can be maintained by delivering a subthreshold direct current (DC) after priming a neural structure with a suprathreshold DC. A waveform generator can provide a DC waveform including a first phase with a first amplitude capable of providing a nerve conduction block of a neural structure within 1 second and a second phase with a second amplitude less than the first amplitude. One or more electrodes can deliver the first phase for to the neural structure for a first time to provide the nerve conduction block of the neural structure within 1 second and deliver the second phase to the neural structure for a second time to maintain the block of the neural structure. By maintaining the DC nerve conduction block with the subthreshold DC, significant power can be saved, resulting in an extended battery life of the waveform generator. 1. A method comprising:configuring, by a waveform generator, a first phase of a direct current waveform with a first amplitude capable of providing a block of a neural structure within 1 second;delivering the first phase of the direct current waveform through one or more electrodes for a first time to provide the block of the neural structure;configuring, by the waveform generator, a second phase of the direct current waveform with a second amplitude less than the first amplitude; anddelivering the second phase of the direct current waveform through the one or more electrodes for a second time to maintain the block of the neural structure.2. The method of claim 1 , wherein the second amplitude is as low as possible to maintain the block of the neural structure.3. The method of claim 1 , wherein the block of the neural structure is a complete block or a partial block.4. The method of claim 1 , wherein the one or more electrodes comprise a surface or transcutaneous electrode.5. The method of claim 1 , wherein the one or more electrodes reside in a cuff.6. The method of claim 1 , wherein the one or more electrodes ...

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Номер записи: 63
28-02-2019 дата публикации

PATTERNED STIMULATION INTENSITY FOR NEURAL STIMULATION

Номер: US20190060648A1
Автор: Schiefer Matthew, Tan Daniel, Tyler Dustin
Принадлежит:

One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal. 1. A method for providing artificial sensation comprising:determining a virtual sensation to be felt by an individual based on a stimulation;configuring a stimulation signal with a pattern of stimulation intensities based on the virtual sensation to be felt by the individual; anddelivering the stimulation signal with the pattern of stimulation intensities to one or more peripheral nerves to cause the individual to experience the virtual sensation.2. The method of claim 1 , further comprising:receiving a feedback signal based on the virtual sensation; andreconfiguring the stimulation signal with a new pattern of stimulation intensities based on the feedback signal.3. The method of claim 1 , wherein the one or more peripheral nerves comprise a median nerve claim 1 , an ulnar nerve claim 1 , and/or a radial nerve.4. The method of claim 1 , wherein individual is an able-bodied individual claim 1 , an amputee claim 1 , a paralyzed individual claim 1 , or a diseased individual.5. The method of claim 1 , wherein the stimulation is related to a touch-enabled virtual reality.6. The method of claim 5 , wherein the touch-enabled virtual reality is related to a user interface claim 5 , a clinical diagnosis claim 5 , a mechanical diagnosis claim 5 , a robotic control claim 5 , and/or a telepresence.7. A system comprising: receive a signal comprising information related to a virtual sensation to be felt by an ...

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Номер записи: 64
17-03-2022 дата публикации

FITTING METHOD USING CHANNELS

Номер: US20220080199A1
Автор: Smith Zachary Mark
Принадлежит:

A method, comprising, fitting an electrical stimulating device to the recipient, the electrical stimulating device including electrodes implanted in the recipient, the electrical stimulating device being a multipolar electrical stimulating device, wherein the fitting includes simultaneously applying multipolar stimulation to the recipient via the electrodes based on at least two different stimulation channels of the electrical stimulating device. 1. A method , comprising:{'claim-text': 'simultaneously applying multipolar stimulation to the recipient via the electrodes based on at least two different multipolar stimulation channels of the electrical stimulating device.', '#text': 'fitting an electrical stimulating device to the recipient, the electrical stimulating device including electrodes implanted in the recipient, the electrical stimulating device being a multipolar electrical stimulating device, wherein the fitting includes:'}2. The method of claim 1 , wherein the action of fitting the stimulating device includes:determining a threshold level specific to the recipient based on the simultaneously applied multipolar stimulation channels.3. The method of claim 1 , wherein the action of fitting the stimulating device includes:determining a comfort level specific to the recipient based on the simultaneously applied multipolar stimulation channels.4. The method of claim 1 , further comprising:developing a first stimulation channel;developing a second stimulation channel, wherein the at least two different stimulation channels include at least the first stimulation channel and the second stimulation channel;identifying one of the first or second stimulation channels as the target channel; andcombining the first and second stimulation channels to make up a merged channel, whereinthe applied simultaneous multipolar stimulation corresponds to the merged channel.5. The method of claim 5 , wherein:the first stimulation channel is the target channel; andthe second ...

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Номер записи: 65
17-03-2022 дата публикации

AUTOTITRATION OF THERAPY USING DETECTED ELECTRICAL ACTIVITY

Номер: US20220080206A1
Автор: Brink Thaddeus S., Nelson Dwight E., Su Xin
Принадлежит:

This disclosure relates to devices, systems, and methods for autotitrating stimulation parameters. In one example, a method includes controlling an implantable medical device to deliver electrical stimulation to a patient according to a plurality of electrical stimulation parameter sets, each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets defining a respective electrical stimulation signal deliverable to the patient, obtaining, by one or more processors and for each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets, a respective signal representative of an electrical response sensed from the patient in response to the electrical stimulation delivered to the patient according to the respective electrical stimulation parameter set, and determining, by the one or more processors and based on the obtained respective signals, a primary electrical stimulation parameter set that defines electrical stimulation therapy deliverable to the patient by the implantable medical device. 114-. (canceled)15. A medical system comprising:an implantable medical device (IMD); anda lead coupled to the IMD, the lead comprising a plurality of electrodes, the plurality of electrodes comprising at least one stimulation electrode configured to deliver electrical stimulation to a target tissue site of a patient and at least one sensing electrode configured to sense one or more bioelectrical signals from the patient,{'claim-text': ['a stimulation generator programmed to deliver, via the at least one stimulation electrode, electrical stimulation to the patient according to a plurality of electrical stimulation parameter sets, each electrical stimulation parameter set of the plurality of electrical stimulation parameter sets defining a respective electrical stimulation signal deliverable to the patient; and', {'claim-text': ['control the stimulation generator to deliver, via the at least one stimulation ...

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Номер записи: 66
10-03-2016 дата публикации

SYSTEMS AND METHODS FOR ENHANCING OR AFFECTING NEURAL STIMULATION EFFICIENCY AND/OR EFFICACY

Номер: US20160067496A1
Автор: Fowler Brad, Gliner Bradford Evan, Kuntz Richard, Leyde Kent, Sheffield W. Douglas, Sloan Leif R., Wyler Allen
Принадлежит:

Systems and methods for enhancing or affecting neural stimulation efficiency and/or efficacy are disclosed. In one embodiment, a system and/or method may apply electromagnetic stimulation to a patient's nervous system over a first time domain according to a first set of stimulation parameters, and over a second time domain according to a second set of stimulation parameters. The first and second time domains may be sequential, simultaneous, or nested. Stimulation parameters may vary in accordance with one or more types of duty cycle, amplitude, pulse repetition frequency, pulse width, spatiotemporal, and/or polarity variations. Stimulation may be applied at subthreshold, threshold, and/or suprathreshold levels in one or more periodic, aperiodic (e.g., chaotic), and/or pseudo-random manners. In some embodiments stimulation may comprise a burst pattern having an interburst frequency corresponding to an intrinsic brainwave frequency, and regular and/or varying intraburst stimulation parameters. Stimulation signals providing reduced power consumption with at least adequate symptomatic relief may be applied prior to moderate or significant power source depletion. 1. A method adjusting electrical stimulation based upon drug therapy comprising:selecting a set of electrical stimulation parameters such that the electrical stimulation accommodates a drug half-life;evaluating a status of the drug half-life and if the drug half-life is not at an acceptable level, then adjust the electrical stimulation to adequately control a patient's symptoms.2. The method of wherein the evaluating the status of the drug half-life comprises assessing the patient's symptoms.3. The method of wherein the drug half-life comprises a drug onset time.4. The method of wherein the evaluating step is performed automatically.5. The method of wherein the evaluating step is performed by a clock or timer.6. The method of wherein the evaluating step is performed in response to receipt and/or analysis of a ...

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Номер записи: 67
08-03-2018 дата публикации

STIMULATION PATTERNS FOR TREATING DRY EYE

Номер: US20180064942A1
Автор: FRANKE Manfred, LOUDIN James Donald
Принадлежит:

Described herein are electrical stimulation patterns and methods of use thereof for treating dry eye disease, tired eye, or other forms of ocular discomfort. The methods generally include applying patterned stimulation to an anatomical structure located in an ocular region or a nasal region to increase tear production. 18-. (canceled)10. The method of claim 9 , wherein the stimulus is delivered to nasal mucosa of the user.11. The method of claim 9 , wherein the stimulus comprises a patterned stimulation waveform.12. The method of claim 11 , wherein the patterned stimulation waveform comprises a pulse shape claim 11 , maximum amplitude claim 11 , and pulse width that are modulated over time.13. The method of claim 12 , wherein the pulse shape is modulated at a frequency of 0.1 Hz.14. The method of claim 12 , wherein the pulse width is modulated between 0 μs and 300 μs.15. The method of claim 12 , wherein the pulse width is modulated over time according to an exponential function.16. The method of claim 9 , wherein the stimulus induces lacrimation in the user.17. The method of claim 9 , wherein the probe comprises at least one electrode claim 9 , and wherein the stimulus is an electrical stimulus.18. The method of claim 17 , wherein the probe is connected to a stimulator body claim 17 , wherein the stimulator body comprises a control subsystem to control the electrical stimulus to be delivered to the subject via the probe.20. The method of claim 19 , wherein the electrical stimulus is delivered to nasal mucosa of the user.21. The method of claim 19 , wherein the electrical stimulus comprises a patterned stimulation waveform.22. The method of claim 21 , wherein the patterned stimulation waveform comprises a pulse shape claim 21 , maximum amplitude claim 21 , and pulse width that are modulated over time.23. The method of claim 22 , wherein the pulse shape is modulated at a frequency of 0.1 Hz.24. The method of claim 22 , wherein the pulse width is modulated between 0 μs ...

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Номер записи: 68
11-03-2021 дата публикации

Patterned stimulation intensity for neural stimulation

Номер: US20210069497A1
Автор: Daniel Tan, Dustin J. Tyler, Matthew SCHIEFER
Принадлежит: CASE WESTERN RESERVE UNIVERSITY

One aspect of the present disclosure relates to a system that can modulate the intensity of a neural stimulation signal over time. A pulse generator can be configured to generate a stimulation signal for application to neural tissue of an individual and modulate a parameter related to intensity of a pattern of pulses of the stimulation signal over time. An electrode can be coupled to the pulse generator and configured to apply the stimulation signal to the neural tissue. A population of axons in the neural tissue can be recruited with each pulse of the stimulation signal.

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Номер записи: 69
11-03-2021 дата публикации

SYSTEMS AND METHODS FOR RESTORING MUSCLE FUNCTION TO THE LUMBAR SPINE

Номер: US20210069509A1
Автор: CROSBY Peter, Rawat Prashant Brijmohansingh, Sachs Dan, SHIROFF Jason
Принадлежит: Mainstay Medical Limited

A system for restoring muscle function to the lumbar spine to treat low back pain is provided. The system may include electrodes coupled to an implantable pulse generator (IPG), a handheld activator configured to transfer a stimulation command to the IPG, and an external programmer configured to transfer programming data to the IPG. The stimulation command directs the programmable controller to stimulate the tissue in accordance with the programming data. The system may include a software-based programming system run on a computer such that the treating physician may program and adjust stimulation parameters. 1. A method of rehabilitating a multifidus muscle to alleviate back pain of a patient , the method comprising:positioning, within the patient, one or more electrodes in or adjacent to tissue associated with the multifidus muscle that is associated with local segmental control of a lumbar spine;delivering electrical stimulation to the tissue via the one or more electrodes to cause the multifidus muscle to contract; anddelivering additional electrical stimulation to the tissue over time via the one or more electrodes to cause the multifidus muscle to contract to rehabilitate the multifidus muscle to thereby improve lumbar spine stability.2. The method of claim 1 , wherein positioning claim 1 , within the patient claim 1 , one or more electrodes comprises:positioning an introducer in or adjacent to the tissue associated with the multifidus muscle;inserting the one or more electrodes through a lumen of the introducer such that the one or more electrodes are positioned in or adjacent to the tissue associated with the multifidus muscle; andretracting the introducer while maintaining the position of the one or more electrodes within the patient.3. The method of claim 2 , wherein the one or more electrodes are disposed on a lead having at least one fixation element claim 2 , and wherein retracting the introducer while maintaining the position of the one or more ...

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Номер записи: 70
11-03-2021 дата публикации

MACHINE LEARNING TO OPTIMIZE SPINAL CORD STIMULATION

Номер: US20210069512A1
Автор: Bokil Hemant, Brill Natalie A., CARCIERI Stephen, Gu Jianwen, Hincapie Ordonez Juan Gabriel, Moffitt Michael A., Zhu Changfang
Принадлежит:

An example of a system may include a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to: access a patient metric of a subject; use the patient metric as an input to a machine learning algorithm, the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets, the candidate neuromodulation parameter set designed to produce a non-regular waveform that varies over a time domain and a space domain; and program a neuromodulator using the candidate neuromodulation parameter set to stimulate the subject. 1. A system comprising:a processor; and access a pain level of a subject;', 'use the pain level to identify a candidate neuromodulation parameter set for a use by a neuromodulator to deliver a non-regular electrical waveform for neuromodulation using electrodes, wherein the non-regular electrical waveform varies in distribution of modulation energy fractionalized across the electrodes; and', 'enable the neuromodulator to treat patient pain using the candidate neuromodulation parameter set to electrically stimulate the subject using the non-regular electrical waveform that varies in the distribution., 'a memory device comprising instructions, which when executed by the processor, cause the processor to2. The system of claim 1 , wherein the processor is configured to use a genetic algorithm to identify the candidate neuromodulation parameter set.3. The system of claim 1 , wherein the processor is configured to use a neural network to identify the candidate neuromodulation parameter set.4. The system of claim 1 , wherein the system is a cloud-based system claim 1 , and wherein the instructions to provide the candidate neuromodulation parameter set comprise instructions to transmit the candidate neuromodulation parameter set to a client device of the cloud-based system.5. The system ...

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Номер записи: 71
17-03-2016 дата публикации

GRAPHICAL USER INTERFACE FOR PROGRAMMING NEUROSTIMULATION PULSE PATTERNS

Номер: US20160074662A1
Автор: Kothandaraman Sridhar, Moffitt Michael A.
Принадлежит:

An example of a neurostimulation system may include a storage device, a programming control circuit, and a graphical user interface (GUI). The storage device may be configured to store individually definable waveforms. The programming control circuit may be configured to generate stimulation parameters controlling the delivery of the neurostimulation pulses according to a pattern. The GUI may be configured to define the pattern using one or more waveforms selected from the individually definable waveforms. The GUI may display waveform tags each selectable for access to a waveform of the individually definable waveforms, and display a waveform builder in response to selection of one of the waveform tags. The waveform builder may present a graphical representation of the accessed waveform and allow for the accessed waveform to be adjusted by editing the graphical representation of the accessed waveform on the GUI. 1. A system for delivering neurostimulation pulses through a plurality of electrodes , comprising:a storage device configured to store a plurality of individually definable waveforms;a programming control circuit configured to generate a plurality of stimulation parameters controlling the delivery of the neurostimulation pulses according to a pattern of the neurostimulation pulses; and display waveform tags each selectable for access to a waveform of the plurality of individually definable waveforms; and', 'display a waveform builder in response to selection of a waveform tag of the waveform tags, the waveform builder configured to present a graphical representation of the accessed waveform and allow for the accessed waveform to be adjusted by editing the graphical representation of the accessed waveform on the GUI., 'a graphical user interface (GUI) coupled to the storage device and the control circuit and configured to define the pattern of the neurostimulation pulses using one or more waveforms selected from the plurality of individually definable ...

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Номер записи: 72
23-03-2017 дата публикации

AUTOMATED PROGRAM OPTIMIZATION

Номер: US20170080234A1
Автор: Doan Que T., Gillespie Christopher Ewan, Moffitt Michael A., Zhu Changfang
Принадлежит:

An example of a system may include a processor; and a memory device comprising instructions, which when executed by the processor, cause the processor to access at least one of: patient input, clinician input, or automatic input; use the patient input, clinician input, or automatic input in a search method, the search method designed to evaluate a plurality of candidate neuromodulation parameter sets to identify an optimal neuromodulation parameter set; and program a neuromodulator using the optimal neuromodulation parameter set to stimulate a patient. 1. A system comprising:a processor; and access at least one of: patient input, clinician input, or automatic input;', 'use the patient input, clinician input, or automatic input in a search method, the search method designed to evaluate a plurality of candidate neuromodulation parameter sets to identify an optimal neuromodulation parameter set of the plurality of candidate neuromodulation parameter sets; and', 'program a neuromodulator using the optimal neuromodulation parameter set to stimulate a patient., 'a memory device comprising instructions, which then executed by the processor, cause the processor to2. The system of claim 1 , wherein the patient input comprises subjective data.3. The system of claim 2 , wherein the subjective data comprises a visual analog scale (VAS) claim 2 , numerical rating scale (NRS) claim 2 , a satisfaction score claim 2 , a global impression of change claim 2 , or an activity level.4. The system of claim 1 , wherein the clinician input comprises a selected neuromodulation parameter set claim 1 , a selected neuromodulation parameter set dimension claim 1 , or a search method configuration option.5. The system of claim 4 , wherein the selected neuromodulation parameter set dimension comprises a spatial location claim 4 , a frequency claim 4 , a pulse width claim 4 , a number of pulses within a burst or train of pulses claim 4 , the train-to-train interval claim 4 , the burst frequency of ...

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Номер записи: 73
12-03-2020 дата публикации

MEDICAL DEVICE WITH A BILATERAL JAW CONFIGURATION FOR NERVE STIMULATION

Номер: US20200078085A1
Автор: Estera Frederick, McLain Cameron D., Messerly Jeffrey D., Nott Cameron R., Papa Christopher A., Shires Peter K., Stulen Foster B., Yates David C.
Принадлежит:

Aspects of the present disclosure are presented for a single surgical instrument configured to grasp, seal, and/or cut tissue through application of therapeutic energy, and also detect nerves through application of non-therapeutic electrical energy. A medical device may include two jaws at an end effector, used to apply therapeutic energy and to perform surgical procedures. The therapeutic energy may be in the form of ultrasonic vibrations or higher voltage electrosurgical energy. One of the jaws may be configured to cut tissue through application of the blade. In addition, one or both of the two jaws may be configured to apply nontherapeutic energy for nerve stimulation probing. The application of therapeutic energy may be disabled while the nontherapeutic nerve stimulation energy is applied, and vice versa. The nontherapeutic nerve stimulation energy may be applied to the use of one or more probes positioned near one or both of the jaws. 121-. (canceled)22. A surgical instrument , comprising:a handle assembly; and a first jaw;', 'a second jaw, wherein the first jaw and second jaw are configurable between an open configuration and a closed configuration, and wherein at least one of the first jaw and the second jaw is configured to deliver first energy to tissue positioned between the first jaw and the second jaw; and', 'a probe movable relative to the handle assembly between an extended configuration and a retracted configuration, wherein the probe is configured to deliver second energy to tissue., 'an end effector operably coupled to the handle assembly, wherein the end effector comprises23. The surgical instrument of claim 22 , wherein the probe comprises a first probe and a second probe.24. The surgical instrument of claim 23 , wherein a gap is defined between a distal end of the first probe and a distal end of the second probe.25. The surgical instrument of claim 24 , wherein the distal end of the first probe and the distal end of the second probe are ...

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Номер записи: 74
12-03-2020 дата публикации

Electromyographic Lead Positioning and Stimulation Titration in a Nerve Stimulation System for Treatment of Overactive Bladder

Номер: US20200078594A1
Автор: JIANG GUANGQIANG, Schmid Eric, Schroeder Dennis, Woock John
Принадлежит:

The present invention provides improved methods for positioning of an implantable lead in a patient with an integrated EMG and stimulation clinician programmer. The integrated clinician programmer is coupled to the implantable lead, wherein the implantable lead comprises at least four electrodes, and to at least one EMG sensing electrode minimally invasively positioned on a skin surface or within the patient. The method comprises delivering a test stimulation at a stimulation amplitude level from the integrated clinician programmer to a nerve tissue of the patient with a principal electrode of the implantable lead. Test stimulations are delivered at a same stimulation amplitude level for a same period of time sequentially to each of the four electrodes of the implantable lead. A stimulation-induced EMG motor response is recorded with the integrated clinician programmer for each test stimulation on each electrode of the implantable lead via the at least one pair of EMG sensing electrodes so as to facilitate initial positioning of the implantable lead at a target stimulation region. 1. (canceled)2. A method for improved positioning of an implantable neurostimulation lead in a patient with a clinician programmer coupled to the implantable neurostimulation lead comprising a plurality of neurostimulation electrodes , wherein at least one EMG sensing electrode is minimally invasively positioned on a skin surface or within the patient , the method comprising:delivering a first test stimulation at a stimulation amplitude level from the clinician programmer to a nerve tissue of the patient with a principal neurostimulation electrode of the implantable neurostimulation lead, wherein the principal neurostimulation electrode is selected from the plurality of neurostimulation electrodes of the implantable neurostimulation lead;delivering one or more second test stimulations at the same stimulation amplitude level as the first test stimulation sequentially to each remaining ...

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Номер записи: 75
25-03-2021 дата публикации

Therapeutic window for treatment of ischemia by vagus nerve stimulation

Номер: US20210085979A1
Автор: David A. FRIEDENBERG, Doug Weber, Patrick GANZER, Seyed Masoud LOEIAN
Принадлежит: Battelle Memorial Institute Inc

Closed-loop stimulation of the Vagus nerve in response to a detected myocardial ischemia state within a therapeutic window can mitigate or reverse effects of the ischemia. This window is between 0 and 50 seconds of the onset of ischemia, before the myocardial ischemia reaches a statistically significant evolution level. A properly trained machine learning system such as a long short-term memory system can be used to analyze cardiovascular features and detect myocardial ischemia within the therapeutic window.

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Номер записи: 76
30-03-2017 дата публикации

User interface with 3d environment for configuring stimulation therapy

Номер: US20170087370A1
Автор: Carl D. Wahlstrand, Lynn M. Otten, Richard T. Stone, Steven M. Goetz, Warren W. Ball
Принадлежит: MEDTRONIC INC

The disclosure describes a method and system that allows a user to configure electrical stimulation therapy by defining a three-dimensional (3D) stimulation field. After a stimulation lead is implanted in a patient, a clinician manipulates the 3D stimulation field in a 3D environment to encompass desired anatomical regions of the patient. In this manner, the clinician determines which anatomical regions to stimulate, and the system generates the necessary stimulation parameters. In some cases, a lead icon representing the implanted lead is displayed to show the clinician where the lead is relative to the 3D anatomical regions of the patient.

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Номер записи: 77
05-05-2022 дата публикации

SYSTEMS AND METHODS FOR STRENGTHENING A RESPIRATORY MUSCLE

Номер: US20220134095A1
Автор: Evans Douglas G., Thakkar Viral S.
Принадлежит: Lungpacer Medical Inc.

This disclosure describes methods and systems for stimulating a respiratory muscle of a patient. The methods herein may include positioning a stimulator adjacent a nerve capable of activating the respiratory muscle; activating the stimulator to cause the respiratory muscle to contract; and ceasing the activation of the stimulator for a period of time. The level and the time of the stimulation may be adjusted for various applications. One or more of the steps in the methods may be repeated. The systems herein may include a stimulator for positioning adjacent a nerve capable of activating the respiratory muscle; a signal generator for providing stimulation energy to the stimulator; a sensor for detecting a response of the respiratory muscle to the stimulation energy; and a controller programmed to control the signal generator for providing stimulation with desired level and time.

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Номер записи: 78
05-05-2022 дата публикации

Programmable autotitrating of electrical parameters of implantable medical device

Номер: US20220134112A1
Автор: Ivan Osorio
Принадлежит: Flint Hills Scientific LLC

We report a method of automatically titrating an electrical therapy administered to a patient by an implanted medical device to a target dosage, comprising programming the medical device with a programmed electrical therapy comprising a first target value for a first therapy parameter; programming at least one titration parameter for automatically adjusting the first therapy parameter from a first value to the first target value over a titration time period initiating the electrical therapy, wherein the first therapy parameter comprises said first value; and automatically titrating the electrical therapy by making a plurality of adjustments to the value of the first therapy parameter, whereby the first electrical therapy parameter is changed from the first value to the first target value according to a titration function. We also report a medical device system configured to implement the method.

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Номер записи: 79
19-03-2020 дата публикации

NEUROMODULATION DEVICE

Номер: US20200086109A1
Автор: Giarrola Alessandra, Lewis Stephen J., SRIDHAR Arun
Принадлежит:

A neuromodulation apparatus for stimulating neural activity in a renal nerve of a patient is provided, the apparatus comprising a transducer Patient for applying a signal to the renal nerve so as to produce a physiological response. Methods of treating sleep apnoea are also provided, including methods using the neuromodulation apparatus. 13.-. (canceled)4. A neuromodulation apparatus for stimulating neural activity in a renal nerve of a patient , the apparatus comprising:an electrode configured to apply an electrical signal to a renal nerve of the patient; anda controller coupled to the electrode, the controller controlling the signal to be applied by each of the electrode, such that the signal increases neural activity in the nerve to produce a physiological response in the patient,wherein the signal comprises an alternating current (AC) waveform and/or a DC waveform.5. An apparatus according to claim 4 , wherein the signal has a frequency of from about 0.5 to about 50 Hz.6. (canceled)7. (canceled)8. An apparatus according to claim 4 , wherein the signal has a voltage of about 1-20V.9. (canceled)10. An apparatus according to claim 4 , wherein the signal has a current of about 0.01-2 mA.11. (canceled)12. (canceled)13. An apparatus according to claim 4 , wherein the signal has a pulse width of about 0.1-5 ms.14. An apparatus according to claim 4 , wherein the signal has a pulse width of less than or equal to about 1 ms.15. (canceled)16. An apparatus according to claim 4 , wherein the signal comprises a DC waveform of about 0.1 mA and about 0.5 ms pulse width claim 4 , with a frequency of about 2-5 Hz.17. An apparatus according to claim 4 , wherein the physiological response is an improvement in one or more physiological parameters selected from: duration of apnoeic episodes claim 4 , frequency of apnoeic episodes claim 4 , sympathetic tone claim 4 , blood pressure claim 4 , heart rate claim 4 , respiratory rate claim 4 , tidal volume claim 4 , upper airway resistance ...

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Номер записи: 80
12-05-2022 дата публикации

LOW HEALTHCARE PROVIDER INTERACTION AND OUTCOME BASED PROGRAMMING

Номер: US20220143403A1
Автор: Bittner Katie C., Offutt Sarah J., Singer Nicholas Reid
Принадлежит:

A medical system for treating incontinence includes an implantable medical device (IMD) implantable proximate to a tibial nerve of a patient comprising therapy delivery circuitry configured to provide electrical stimulation therapy proximate the tibial nerve of the patient for treating incontinence, and processing circuitry configured to: during an implant period, determine a set of stimulation parameters to control the therapy delivery circuitry, during an induction period after the implant period, initiate electrical stimulation therapy according to the set of stimulation parameters, during a first maintenance period, determine an adjustment to the set of stimulation parameters as first maintenance period stimulation parameters to reduce the electrical stimulation therapy from the induction period, and during a second maintenance period, determine an adjustment to the set of stimulation parameters as second maintenance period stimulation parameters to reduce the electrical stimulation therapy from the first maintenance period. 1. A medical system for treating incontinence comprising:an implantable medical device (IMD) implantable proximate to a tibial nerve of a patient, the IMD comprising therapy delivery circuitry configured to provide electrical stimulation therapy proximate the tibial nerve of the patient for treating incontinence; and during an implant period, determine a set of stimulation parameters to control the therapy delivery circuitry,', 'during an induction period after the implant period, initiate electrical stimulation therapy according to the set of stimulation parameters,', 'during a first maintenance period, determine an adjustment to the set of stimulation parameters as first maintenance period stimulation parameters to reduce the electrical stimulation therapy from the induction period, wherein the therapy delivery circuitry provides the electrical stimulation therapy according to the first maintenance period stimulation parameters, and', ' ...

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Номер записи: 81
12-05-2022 дата публикации

APPARATUS AND METHODS FOR PHASE-AGNOSTIC STIMULI

Номер: US20220143412A1
Автор: CHANG Joshua, HACKETT Sara A., PAYDARFAR David, SRIDHAR Varun K.
Принадлежит: RESEARCH DEVELOPMENT FOUNDATION

Apparatus and methods for applying a phase-agnostic stimuli are disclosed herein. Certain embodiments include methods and apparatus that are configured to receive a detected signal from a subject and transmit a stimulation signal that is configured to optimize a response signal without regard to the phase of the detected signal. 1. An apparatus for applying a therapeutic treatment to a subject , the apparatus comprising:a stimulation electrode; and receive a detected signal from the subject;', 'transmit a first stimulation signal to the subject via the stimulation electrode, wherein the first stimulation signal is transmitted at a phase of the detected signal;', 'receive a response signal from the subject; and', 'transmit a second stimulation signal to the subject via the stimulation electrode, wherein the second stimulation signal is configured to optimize the response signal without regard to the phase of the detected signal., 'a programmable arbitrary waveform generator, wherein the programmable arbitrary waveform generator is configured to2. The apparatus of wherein the detected signal is received from a detection electrode.3. The apparatus of wherein the detection electrode is a separate component coupled to the apparatus.4. The apparatus of wherein the detection electrode is integral to the apparatus.5. The apparatus of wherein the programmable arbitrary waveform generator is configured to:transmit a third stimulation signal via the stimulation electrode;receive a second response signal from the subject; andtransmit a fourth stimulation signal, to the subject via the stimulation electrode, wherein the fourth stimulation signal is configured to optimize the second response signal without regard to the phase of the detected signal.6. The apparatus of wherein the programmable arbitrary waveform generator is configured to apply subsequent stimulation signals and receive subsequent response signals in an iterative process.7. The apparatus of wherein the second ...

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Номер записи: 82
28-03-2019 дата публикации

METHODS AND DEVICES FOR ACTIVATING BROWN ADIPOSE TISSUE USING ELECTRICAL ENERGY

Номер: US20190091464A1
Автор: Baynham Tamara C., Harris Jason L.
Принадлежит:

Methods and devices are provided for activating brown adipose tissue (BAT) using electrical energy. In general, the methods and devices can facilitate activation of BAT to increase thermogenesis. The BAT can be activated by applying an electrical signal thereto that can be configured to target sympathetic nerves that can directly innervate the BAT. The electrical signal can be configured to target the sympathetic nerves using fiber diameter selectivity. In other words, the electrical signal can be configured to activate nerve fibers having a first diameter without activating nerve fibers having diameters different than the first diameter. Sympathetic nerves include postganglionic unmyelinated, small diameter fibers, while parasympathetic nerves that can directly innervate BAT include preganglionic myelinated, larger diameter fibers. The electrical signal can be configured to target and activate the postganglionic unmyelinated, small diameter fibers without activating the preganglionic myelinated, larger diameter fibers. 1. A medical apparatus , comprising:a device configured to be positioned in contact with tissue of a patient and configured to be activated, when so positioned, to deliver an electrical signal to the patient using an electrode of the device and thereby activate a first type of neurons in brown adipose tissue (BAT) of the patient without activating a second, different type of neurons in the BAT.2. The apparatus of claim 1 , wherein the first type of neurons are unmyelinated neurons claim 1 , and the second type of neurons are myelinated neurons.3. The apparatus of claim 1 , wherein the first type of neurons have a first diameter claim 1 , and the second type of neurons have a second diameter that is greater than the first diameter.4. The apparatus of claim 1 , wherein the electrical signal has a peak current that is in a range of about 50 mA to 100 mA.5. The apparatus of claim 1 , wherein the device is configured to be positioned in contact with ...

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Номер записи: 83
26-06-2014 дата публикации

Brain stimulation response profiling

Номер: US20140180358A1
Автор: Jonathon E. Giftakis, Paul H. Stypulkowski, Scott R. Stanslaski, Timothy J. Denison
Принадлежит: MEDTRONIC INC

Various embodiments concern delivering electrical stimulation to the brain at a plurality of different levels of a stimulation parameter and sensing a bioelectrical response of the brain to delivery of the electrical stimulation for each of the plurality of different levels of the stimulation parameter. A suppression window of the stimulation parameter can be identified as having a suppression threshold as a lower boundary and an after-discharge threshold as an upper boundary based on the sensed bioelectrical responses. A therapy level of the stimulation parameter can be set for therapy delivery based on the suppression window. The therapy level of the stimulation parameter may be set closer to the suppression threshold than the after-discharge threshold within the suppression window. Data for hippocampal stimulation demonstrating a suppression window is presented.

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Номер записи: 84
13-04-2017 дата публикации

SYSTEMS AND METHODS FOR PROGRAMMING AND OPERATING DEEP BRAIN STIMULATION ARRAYS

Номер: US20170100601A1
Автор: Johnson Matthew Douglas, Peña Edgar, Xiao Yizi
Принадлежит:

Systems, methods and apparatus for determining and/or programming stimulation settings for a pulse generator capable of steering current to a deep brain stimulation array are disclosed. Individual patient brain geometry and lead specific geometry data can be used to generate a maximum activation function curve. Optimization methods can be used to find stimulation settings that are as close as possible to achieving the value of the maximum activation function curve. 1. A method for determining a stimulation setting for each electrode in a deep brain stimulation array including one or more electrodes , the method comprising:identifying one or more grid points representing a target tissue to be activated by stimulation through the one or more electrodes;calculating a maximum activation function value for each of the one or more grid points;determining a set of stimulation settings for each of the one or more electrodes such that an actual activation function value for each of the one or more grid points is as close as possible to the maximum activation function value calculated for each of the one or more grid points; andproviding, to a pulse generator capable of delivering therapy via each of the one or more electrodes, the set of stimulation settings for each electrode.2. The method of claim 1 , wherein the identifying comprises:receiving brain geometry data;receiving lead geometry data; andgenerating, from the brain geometry data and the lead geometry data, the one or more grid points representing a target tissue to be activated.3. The method of claim 1 , wherein the determining comprises minimizing a maximum deviation between the maximum activation function value and the actual activation function value for each of the one or more grid points.4. The method of claim 1 , wherein the determining comprises minimizing a difference between the maximum activation function value and the actual activation function value for each of the one or more grid points.5. The method ...

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Номер записи: 85
04-04-2019 дата публикации

ORAL MUSCLE TRAINING

Номер: US20190099598A1
Автор: Sama Anshul
Принадлежит:

A trans mucosal neuromuscular electrical stimulation device including a mouthpiece, electrodes associated with the mouthpiece. The device and/or mouthpiece incorporates electrical circuitry operatively connecting to the electrodes to a power source and is configured to provide, in use, electrical stimulation to one or more palate and/or tongue muscles via the electrodes through the oral mucosa. The treatment regime, including the location of stimulation and the parameters used, is designed to increase resting muscle tone and/or muscle tone during sleep. 1. A trans mucosal neuromuscular electrical stimulation device comprising a mouthpiece , the mouthpiece comprises a pair or arms joined together at one end and diverging from one another , at least one of the arms comprises a first member shaped to cooperate with or approximate or accommodate a dorsal tongue surface , and at least one of the said pair of arms comprises a second member , wherein the first member comprises a first electrode , and the second member comprises a second electrode , the mouthpiece further comprises electrical circuitry operatively connected to the first and second electrodes , wherein the device is configured to provide , in use , via the first electrode to the second electrode or via the second electrode to the first electrode , electrical stimulation from a first side to a second side of the mouthpiece , through the tongue to increase resting muscle tone and/or muscle tone during sleep.2. A device according to claim 1 , wherein the second member is shaped to cooperate with or approximate or accommodate a dorsal tongue surface.3. A device according to claim 1 , wherein the first member comprises a flange shaped to cooperate with or approximate or accommodate a dorsal tongue surface.4. A device according to claim 1 , wherein the second member is shaped to cooperate with or approximate or accommodate a dorsal tongue surface.5. A device according to claim 4 , wherein the second member ...

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Номер записи: 86
02-06-2022 дата публикации

COMBINATION HEARING AID AND COCHLEAR IMPLANT SYSTEM

Номер: US20220168570A1
Автор: MAZANEC PAUL R.
Принадлежит:

Cochlear implant systems can comprise a cochlear implant system comprising a cochlear electrode, a stimulator, an input source, and an implantable battery and/or communication module. The signal processor may be programmed with a transfer function and be configured to receive input signals from the input source and output a stimulation signal to the stimulator based on the received input signals with the transfer function. The system may be configured to receive a status indicator signal indicative of whether an external auditory aid device is active and update the transfer function of the signal processor if the external auditory aid device is active. For example, the signal processor can operate programmed with a first transfer function if the external auditory aid device is not active and with a second transfer function if the external auditory aid device is active. 1. A system comprising: a cochlear electrode;', 'a stimulator in electrical communication with the cochlear electrode;', 'an input source configured to receive a stimulus and generate an input signal representative of the received stimulus, wherein the received stimulus is representative of an external acoustic signal;', 'a signal processor in communication with the stimulator and the input source, the signal processor being programmed with a transfer function and being configured to receive one or more input signals from the input source and output a stimulation signal to the stimulator based on the received one or more input signals and the transfer function; and', 'an implantable battery and/or communication module in communication with the signal processor and being configured to provide electrical power to the signal processor; and, 'a cochlear implant system comprising receive a status indicator signal indicative of whether an external auditory aid device is active; and', 'update the transfer function of the signal processor to compensate for operation of the external auditory aid device if the ...

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Номер записи: 87
29-04-2021 дата публикации

Methods and Apparatus for Stimulation of Biological Tissue

Номер: US20210121693A1
Автор: Bono David, Boyden Edward, Grossman Nir
Принадлежит:

In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents. 1. A method comprising:(a) creating a first electric field between a first pair of electrodes and creating a second electric field between a second pair of electrodes, in such a way that the first and second electric fields constructively and destructively interfere with each other to create an amplitude-modulated waveform, which waveform has an envelope amplitude; and(b) controlling location of a spatial position at which the envelope amplitude of the waveform is greatest, in such a way that the spatial position is located in biological tissue.2. The method of claim 1 , wherein the first and second pairs of electrodes are positioned in such a way that:(a) the first pair of electrodes is positioned entirely on one side of a geometric plane;(b) the second pair of electrodes is positioned entirely on another side of the geometric plane; and(c) the geometric plane intersects the biological tissue.3. The method of claim 1 , wherein distance between electrodes in the first pair of electrodes is different than distance between electrodes in the second pair of ...

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Номер записи: 88
02-04-2020 дата публикации

SYSTEMS AND METHODS FOR PROGRAMMING NEUROMODULATION WAVEFORM

Номер: US20200101284A1
Автор: Marnfeldt Goran N., Moffitt Michael A.
Принадлежит:

This document discusses, among other things, systems and methods for programming neuromodulation therapy to treat neurological or cardiovascular diseases. A system includes an input circuit that receives a modulation magnitude representing a level of stimulation intensity, a memory that stores a plurality of gain functions associated with a plurality of modulation parameters, and a electrostimulator that may generate and deliver an electrostimulation therapy. A controller may program the electrostimulator with the plurality of modulation parameters based on the received modulation magnitude and the plurality of gain functions, and control the electrostimulator to generate electrostimulation therapy according to the plurality of modulation parameters. 1. A method for providing electrostimulation to a patient via an ambulatory medical device (AMD) communicatively coupled to an external programmer device , the method comprising:receiving, via the external programmer device, at least a single user input corresponding to a modulation magnitude;determining, via the external programmer device, respective values for a plurality of modulation parameters based on the received single user input of the modulation magnitude; andproviding, via the AMD, an electrostimulation therapy to the patient in accordance with the determined respective values for the plurality of modulation parameters.2. The method of claim 1 , wherein determining the respective values for the plurality of modulation parameters includes using a plurality of gain functions each defining a correspondence between a modulation parameter and the modulation magnitude.3. The method of claim 1 , wherein determining the respective values for the plurality of modulation parameters includes using a plurality of lookup tables each defining a correspondence between a modulation parameter and the modulation magnitude.4. The method of claim 1 , wherein the plurality of modulation parameters includes at least a temporal ...

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Номер записи: 89
11-04-2019 дата публикации

NEURONAL STIMULATION MODEL, DEVICE AND METHODS USING ALTERNATE CURRENT

Номер: US20190105498A1
Автор: Tang-Schomer Min
Принадлежит:

The present disclosure relates generally to models and methods to modulate neuronal network activities simulating normal brain functions or neurological disorders in culture by applying alternating electric field. The electric filed has alternating polarity and changing frequencies to achieve neuronal synchrony. The present disclosure also provides method of modulating modulate directed growth of neuronal axon by applying an alternating field electrical signal. The present disclosure also provides methods of screening compounds using the disclosed models, kits and systems thereof. 1. A method of modulating neuronal network activities comprising applying an alternating electric field (EF) to a neuronal network of neuronal cells in culture for a period of time , wherein the activities are synchronizing or desynchronizing the neuronal network of neuronal cells.2. The method of wherein the neuronal network activities simulate normal brain functions.3. The method of wherein the neuronal network activities simulate neurological disorders.4. The method of wherein the neurological disorder is Alzheimer's claim 3 , Parkinson's claim 3 , stroke claim 3 , spinal cord injury or schizophrenia.5. The method of wherein the culture comprises an electrode or electrode array-embedded silk protein film-based substrate.6. The method of wherein the EF is applied to a random neuronal network.7. The method of wherein the neuronal cells are cortical neuron claim 1 , medulla neuron claim 1 , inner neuron claim 1 , spinal cord neuron or a combination thereof.8. The method of wherein the neuronal cells were cultured for about 1-3 weeks before the EF was applied.9. (canceled)10. The method of wherein the neuronal cells comprise functional neuronal cells claim 1 , wherein the functional neuronal cells are evaluated by electron microscopy claim 1 , physiological measurement claim 1 , electric impulse claim 1 , electric potential claim 1 , neuronal connectivity or neuronal marker.11. The method ...

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Номер записи: 90
26-04-2018 дата публикации

SYSTEM FOR LOCATION-DEPENDENT THERAPY DELIVERY

Номер: US20180110983A1
Автор: GROSSKOPF RAINER JOERG, Reinert Michael
Принадлежит:

A system for spinal cord stimulation, includes a stimulation device having a plurality of electrodes. The stimulation device is configured to deliver spinal cord stimulation via the electrodes according to a set of stimulation parameters. The stimulation device is further configured to store a plurality of different sets of stimulation parameters. The stimulation device is further configured to select one of the stored sets and to deliver spinal cord stimulation according to this selected set, when the stimulation device or a component of the system is located in proximity to an external activator associated with the selected set. 1. A system for spinal cord stimulation , the system comprising:an external activator associated with a set of stimulation parameters; anda stimulation device having a plurality of electrodes, said stimulation device being configured to deliver spinal cord stimulation via said electrodes according to said set of stimulation parameters, said stimulation device being further configured to store a plurality of different sets of stimulation parameters, and said stimulation device being further configured to select one of said stored sets and to deliver spinal cord stimulation according to said selected set, when said stimulation device or a component of the system is located in proximity to said external activator associated with said selected set.2. The system according to claim 1 , wherein said component is an external component.3. The system according to claim 1 , wherein said component is configured to transmit control signals to said stimulation device for operating said stimulation device.4300. The system according to claim 1 , wherein said stimulation device includes a detecting unit for detecting said external activator ().5. The system according to claim 4 , wherein said detecting unit is configured to detect an electromagnetic signal from said external activator identifying a set of stimulation parameters associated with said ...

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Номер записи: 91
09-06-2022 дата публикации

NEURONAL STIMULATION MODEL, DEVICE AND METHODS USING ALTERNATE CURRENT

Номер: US20220176126A1
Автор: Tang-Schomer Min
Принадлежит:

Described is a method of modulating neuronal network activities, the method including applying an alternating electric field (EF) to a neuronal network of neuronal cells in culture for a period of time, and increasing or decreasing a frequency of the alternating EF after the period of time to provide the neuronal network activities that are synchronizing or desynchronizing the neuronal network of neuronal cells in the culture, wherein increasing the frequency of the alternating electric field provides synchronizing neuronal network activities, and wherein decreasing the frequency of the alternating electric field provides desynchronizing neuronal network activities. 1. A method of modulating neuronal network activities comprisingapplying an alternating electric field (EF) to a neuronal network of neuronal cells in culture for a period of time, andincreasing or decreasing a frequency of the alternating EF after the period of time to provide the neuronal network activities that are synchronizing or desynchronizing the neuronal network of neuronal cells in the culture,wherein increasing the frequency of the alternating electric field provides synchronizing neuronal network activities, andwherein decreasing the frequency of the alternating electric field provides desynchronizing neuronal network activities.2. The method of claim 1 , wherein the EF is applied by increasing the frequency from about 0.2 Hz to about 200 kHz claim 1 , wherein the EF is applied by decreasing the frequency from 200 kHz to 0.2 Hz.3. The method of claim 1 , wherein the neuronal network activities simulate normal brain functions.4. The method of claim 1 , wherein the neuronal network activities simulate neurological disorders.5. The method of claim 3 , wherein the neurological disorder is Alzheimer's claim 3 , Parkinson's claim 3 , stroke claim 3 , spinal cord injury or schizophrenia.6. The method of wherein the culture comprises an electrode or electrode array-embedded substrate.7. The method of ...

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Номер записи: 92
03-05-2018 дата публикации

Implantable neuro-stimulation device

Номер: US20180117332A1
Автор: David Robinson, Ernest Mantes, Tracy Cameron
Принадлежит: Mudjala Medical Pty Ltd

An implantable electrical stimulation device includes an electrically conductive electrode structure configured for coupling with a pulse generator device and transmitting an electrical signal configured to generate a desirable electric field around a target tissue. The electrode structure includes a porous substrate constructed of a bio-compatible and bio-survivable material having a structure that mimics extracellular matrix embedding. The porous substrate supports an electrically conductive electrode element. The implantable device may further include a pulse generator also embedded, enmeshed, and supported within the porous substrate.

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Номер записи: 93
03-05-2018 дата публикации

USE OF A SEPARATE DEVICE IN MANAGING THE PACE PULSE ENERGY OF A CARDIAC PACEMAKER

Номер: US20180117336A1
Автор: Ludwig Jacob M., Maile Keith R.
Принадлежит: Cardiac Pacemakers, Inc.

A medical system may include a first medical device such as a leadless cardiac pacemaker (LCP) that is configured to pace a patient's heart and a second medical device that is configured to have a capture threshold capability. The second medical device may monitor the patient's heart to ascertain whether the pacing pulses from the first medical device are capturing the heart, and to send the first medical device instructions to alter an energy level of subsequent pacing pulses. 1. A leadless cardiac pacemaker (LCP) configured to pace a patient's heart , the LCP disposable within a chamber of the patient's heart , the LCP comprising:a housing;a pair of pacing electrodes secured relative to the housing;a controller disposed within the housing and operably coupled to the pair of pacing electrodes, the controller configured to generate and deliver a plurality of pacing pulses via the pair of pacing electrodes, wherein each of the plurality of pacing pulses has a controllable pacing energy level; anda communications module operably coupled to the controller, the communications module configured to receive a pacing energy signal from a second implantable medical device that results from an automatic capture threshold capability of the second implantable medical device, wherein the pacing energy signal causes the controller of the LCP to change the pacing energy level of one or more subsequent pacing pulses of the plurality of pacing pulses.2. The LCP of claim 1 , wherein the controller is free of a capture verification capability.3. The LCP of claim 1 , wherein the controller is configured to change the pacing energy level by adjusting a voltage of one or more of the subsequent pacing pulses.4. The LCP of claim 1 , wherein the controller is configured to change the pacing energy level by adjusting a pulse width of one or more of the subsequent pacing pulses.5. The LCP of claim 1 , wherein the pacing energy signal causes the controller to increase the pacing energy level ...

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Номер записи: 94
04-05-2017 дата публикации

SYSTEMS AND METHODS FOR PROGRAMMING IMPLANTABLE DEVICES

Номер: US20170120062A1
Автор: Kumar Prasanna
Принадлежит:

The present disclosure provides systems and methods for programming an implanted device when a patient is remote from a clinician. A system includes a patient programmer configured to be operated by the patient, a clinician programmer configured to be operated by the clinician, and a remote diagnostic server configured to facilitate secure communication between the patient programmer and the clinician programmer, wherein the remote diagnostic server is configured to initiate a secure programming session between the patient programmer and the clinician programmer, receive a proposed stimulation program from the clinician programmer, transmit the proposed stimulation program to the patient programmer, receive an indication from the patient programmer that the patient has accepted the proposed stimulation program, and transmit an alert to the clinician programmer, the alert indicating that the patient has accepted the proposed stimulation program. 1. A system for programming an implanted device when a patient is remote from a clinician , the system comprising:a patient programmer configured to be operated by the patient;a clinician programmer configured to be operated by the clinician; and initiate a secure programming session between the patient programmer and the clinician programmer;', 'receive a proposed stimulation program from the clinician programmer;', 'transmit the proposed stimulation program to the patient programmer;', 'receive an indication from the patient programmer that the patient has accepted the proposed stimulation program; and', 'transmit an alert to the clinician programmer, the alert indicating that the patient has accepted the proposed stimulation program., 'a remote diagnostic server configured to facilitate secure communication between the patient programmer and the clinician programmer, wherein the remote diagnostic server is configured to2. The system of claim 1 , further comprising a representative programmer claim 1 , wherein the remote ...

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Номер записи: 95
25-08-2022 дата публикации

Selective Electrical Modulation of Neural Populations

Номер: US20220265999A1
Автор: Bokil Hemant
Принадлежит:

Methods of providing electrical neural modulation to a patient's brain are disclosed herein. The methods involve differentially modulating two or more target regions of the brain. For example, a first target region may be provided with an electrical neural modulation signal that activates that target region while a second target region is provided with an electrical neural modulation signal that suppresses or deactivates that target region. As the implantable pulse generators (IPGs) described herein include independent current sources, such differential modulation can be provided with a single IPG. 1. A method of providing electrical stimulation to a patient's brain using one or more electrode leads implantable in the patient's brain , wherein each electrode lead comprises a plurality of electrodes , the method comprising:identifying a first neural target for excitation in the brain,identifying a second neural target for suppression in the brain, based on the first identified neural target, using a first one or more of the electrodes to issue a first stimulation waveform to the first neural target, wherein the first stimulation waveform comprises one or more pulses having a first polarity, andbased on the second identified neural target, using a second one or more electrodes to issue a second stimulation waveform to the second neural target, wherein the second stimulation waveform comprises one or more pulses having a second polarity opposite of the first polarity.2. The method of claim 1 , wherein the first stimulation waveform is configured to excite the first neural target.3. The method of claim 1 , wherein the second stimulation waveform is configured to suppress activity of the second neural target.4. The method of claim 1 , wherein the both the first and second stimulation waveforms are monophasic waveforms.5. The method of claim 4 , wherein the first stimulation waveform comprises first pulses having a first amplitude and a first pulse width claim 4 , and ...

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Номер записи: 96
25-04-2019 дата публикации

Methods and Apparatus for Stimulation of Biological Tissue

Номер: US20190117975A1
Автор: Bono David, Boyden Edward, Grossman Nir
Принадлежит:

In illustrative implementations of this invention, interferential stimulation is precisely directed to arbitrary regions in a brain. The target region is not limited to the area immediately beneath the electrodes, but may be any superficial, mid-depth or deep brain structure. Targeting is achieved by positioning the region of maximum envelope amplitude so that it is located at the targeted tissue. Leakage between current channels is greatly reduced by making at least one of the current channels anti-phasic: that is, the electrode pair of at least one of the current channels has a phase difference between the two electrodes that is substantially equal to 180 degrees. Pairs of stimulating electrodes are positioned side-by-side, rather than in a conventional crisscross pattern, and thus produce only one region of maximum envelope amplitude. Typically, current sources are used to drive the interferential currents. 1. A method comprising:(a) creating a first electric field between a first pair of electrodes and creating a second electric field between a second pair of electrodes, in such a way that the first and second electric fields constructively and destructively interfere with each other to create an amplitude-modulated waveform (“AM waveform”), which AM waveform has an envelope amplitude; and(b) controlling location of a spatial position at which the envelope amplitude of the AM waveform is greatest, in such a way that the spatial position is located in a brain of a person.2. The method of claim 1 , wherein the first and second pairs of electrodes are positioned on the scalp of the person in such a way that:(a) the first pair of electrodes is positioned entirely on one side of a geometric plane;(b) the second pair of electrodes is positioned entirely on another side of the geometric plane; and(c) the geometric plane intersects the brain of the person.3. The method of claim 1 , wherein distance between electrodes in the first pair of electrodes is different than ...

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Номер записи: 97
27-05-2021 дата публикации

MANAGEMENT OF STIMULATION SAFETY LIMITS IN A NEUROSTIMULATION SYSTEM

Номер: US20210154479A1
Автор: Moffitt Michael A., Steinke Gustav Karl
Принадлежит:

An electrical stimulation system for use with a plurality of electrodes implanted within a tissue region comprises a neurostimulator configured for delivering electrical stimulation energy to the plurality of electrodes in accordance with a set of stimulation parameters, thereby injecting a charge into the tissue region, a control device configured for receiving user input to modify the set of stimulation parameters, and controller/processor circuitry configured for, in response to the user input computing a charge injection metric value as a function of a physical electrode parameter and an electrical source parameter for a first set of the electrodes, wherein the electrode set comprises at least two electrodes, comparing the computed charge injection metric value to a safety threshold value, and performing a corrective action based on the comparison. 1. A neurostimulation system , comprising:a memory having a safety threshold value stored in the memory; and computing, for a set of stimulation parameters, a charge injection metric value as a function of at least two parameters and a weighting value for each of at least two active electrodes, wherein the weighting value is based on proximity of the at least two active electrodes to each other or to a reference electrode;', 'comparing the computed charge injection metric value to the safety threshold value; and', 'performing a corrective action based on the comparison., 'a processor coupled to the memory and configured for'}2. The neurostimulation system of claim 1 , wherein the at least two parameters comprises a physical electrode parameter and an electrical source parameter.3. The neurostimulation system of claim 2 , wherein the physical electrode parameter is at least one of an electrode surface area claim 2 , an electrode surface shape claim 2 , and an electrode material.4. The neurostimulation system of claim 2 , wherein the electrical source parameter is at least one of a current claim 2 , a voltage claim 2 , ...

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Номер записи: 98
12-05-2016 дата публикации

WAVEFORM SHAPES FOR TREATING NEUROLOGICAL DISORDERS OPTIMIZED FOR ENERGY EFFICIENCY

Номер: US20160129258A1
Автор: GRILL WARREN M., Wongsarnpigoon Amorn
Принадлежит:

Systems and methods for stimulation of neurological tissue apply a stimulation waveform that is derived by a developed genetic algorithm (GA), which may be coupled to a computational model of extracellular stimulation of a mammalian myelinated axon. The waveform is optimized for energy efficiency. 1. A stimulation waveform for application to targeted neurological tissue , the stimulation waveform being selected from a set of stimulus waveforms consisting essentially of Gaussian curves having varying pulse widths and derived by a prescribed genetic algorithm coupled to a computational model of extracellular stimulation of a mammalian myelinated axon , wherein the set of stimulus waveforms are optimized for energy efficiency.2. A waveform according to claim 1 , wherein the stimulation waveform is monophasic.3. A waveform according to claim 1 , wherein the stimulation waveform is biphasic.4. A method for stimulating neurological tissue comprising:applying a stimulation waveform optimized for energy efficiency derived by a prescribed genetic algorithm coupled to a computational model of extracellular stimulation of a mammalian myelinated axon.5. A method according to claim 4 ,(i) wherein the prescribed genetic algorithm generates a population of offspring stimulation waveforms by mating a population of parent stimulation waveforms;(ii) wherein the computational model of extracellular stimulation of a mammalian myelinated axon assesses fitness of individual offspring stimulation waveforms generated by the prescribed genetic algorithm in terms of energy efficiency and selects as a new population of parent stimulation waveforms current offspring stimulation waveforms having highest energy efficiency values; and(iii) wherein (i) and (ii) are repeated until predetermined termination criteria is met.6. A method according to claim 5 , wherein the termination criteria includes fitness of successive populations of offspring stimulation waveforms converging toward a common energy ...

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Номер записи: 99
14-05-2015 дата публикации

PUDENDAL AND SACRAL NERVE STIMULATION SWEEP ALGORITHM AND METHOD

Номер: US20150134026A1
Автор: Iyassu Yohannes, Kaula Norbert
Принадлежит:

In response to input from a patient who is being treated by a sacral nerve stimulation therapy, an electronic diary is generated that includes a plurality of voiding responses of the patient over a period of time. The sacral nerve stimulation therapy includes electrical pulses delivered to the patient according to a first stimulation program and via a first subset of electrode contacts on a lead that is implanted in the patient. The lead has a plurality of electrode contacts that include the first subset. Based on the voiding responses in the electronic diary, a loss of efficacy of the sacral nerve stimulation therapy is detected. The sacral nerve stimulation therapy is automatically adjusted in response to the detected loss of efficacy. The automatically adjustment of the sacral nerve stimulation therapy may include either a program-based sweep or a contact-based sweep. 1. A medical system for treating a patient , comprising:an implantable lead having a plurality of electrode contacts;a pulse generator coupled to the lead and configured to generate electrical pulses to be delivered to a patient through the electrode contacts; and a graphical user interface module configured to receive input from, and display output to, a user;', 'a memory storage module configured to store instructions; and', generating, at least in part via the graphical user interface, an electronic diary in response to input from the patient who is being treated by the sacral nerve stimulation therapy, wherein the electronic diary includes a plurality of voiding responses of the patient over a period of time, and wherein the sacral nerve stimulation therapy includes electrical pulses delivered to the patient according to a first stimulation program and via a first subset of the electrode contacts on the lead;', 'detecting, based on the voiding responses in the electronic diary, a loss of efficacy of the sacral nerve stimulation therapy; and', identifying, from a plurality of predefined ...

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Номер записи: 100