14-03-2013 дата публикации
Номер: US20130066190A1
Принадлежит:
A method and composition for hyperthermally treating tumor cells in a patient under conditions that affect tumor stem cells and tumor cells. In one embodiment, the method is administered in combination with localized internal ionizing radiation therapy. 1. A method of simultaneously providing localized internal ionizing radiation therapy in combination with thermal therapy to a target site in a patient in need thereof , the method comprisingadministering to the patient a composition of nanoparticles, the nanoparticles containing at least one radioactive isotope and coated with anti-tumor antibodies, the radioactive nanoparticle resulting in radiation therapy at a dose sufficient to damage tumor-associated vessels at the localized target site, andadministering localized thermal therapy at the target site essentially simultaneously during the radiation therapy.3. The method of where the target is a tumor site.4. The method of where the target is neovascularization tissue.5. The method of where the target is endothelial cells in new blood vessels in a patient with exudative age related macular degeneration.6. The method of wherein the radioactive nanoparticle is a magnetic claim 1 , diamagnetic claim 1 , ferromagnetic claim 1 , non-ferromagnetic and/or paramagnetic nanoparticle.7. The method of wherein the antitumor antibody is coated on or conjugated with the radioactive nanoparticle.8. The method of wherein the composition is administered intravenously.9. The method of wherein the radioactive isotope is an α-emitting isotope claim 1 , a β-emitting isotope claim 1 , or a combination thereof.10. The method of wherein the isotope is selected from the group consisting of AtAc claim 9 , Bi claim 9 , Bi claim 9 , Ra claim 9 , Pb claim 9 , Tb claim 9 , I claim 9 , cu claim 9 , I claim 9 , Bi claim 9 , and Bi11. The method of wherein the dose of the isotope ranges from 10 μCi to 20 claim 9 ,000 μCi.12. The method of wherein thermal therapy is applied with a controlled energy ...
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