Implantable ultrasonic transmitter-Arrangement for the treatment of a person.

Die Erfindung betrifft eine Ultraschallsender-Anordnung (1) mit einer an der Anordnung verteilt angeordneten Vielzahl von Ultraschallsendern (2), deren ausstrahlbare Ultraschallwellen zu einem gemeinsamen Fokus hin fokussiert sind. Die Anordnung (1) ist als Schädelknochen-Implantat (4) ausgebildet, welches als Ersatz für einen Teil des Schädelknochens (5) einer Person in deren Schädelknochen (5) implantierbar ist, wobei im implantierten Zustand der gemeinsame Fokus der Anordnung in einer definierten Hirnregion liegt.

METHODS AND DEVICES FOR MODULATING CELLULAR ACTIVITY USING ULTRASOUND

Ultrasound transducer array monitoring during transcranial ultrasound procedures

一种超声系统使用安装到对象的头部的头戴件来执行颅骨治疗，所述头戴件包含治疗换能器和运动检测换能器。在治疗开始时，回波信号由所述运动检测换能采集并存储。其后，回波信号由所述运动检测换能器再次采集并与在治疗开始时存储的信号进行比较或相关。当在所比较或相关的信号之间确定差异时，由所述系统发出可能已经发生了换能器运动或声学解耦的警告。

Methods and apparatus for renal neuromodulation

本发明提供了用于肾神经调节的方法和装置，其使用脉冲电场进行电穿孔或电融合。除了别的以外，预计肾神经调节作用(例如，去除神经作用)可以减少急性心肌梗塞的扩张，减少或防止与充血性心力衰竭相关的形态学变化的发作，和/或有效用于肾病晚期的治疗。本发明的实施方案设置成经皮血管内输送脉冲电场以实现这样的神经调节作用。

PHOTODYNAMIC THERAPY DEVICE THAT SECURES LIGHT TRANSMISSION DEPTH BY FOCUSED ULTRASONIC WAVE GUIDANCE AND METHOD OF CONTROLLING LIGHT OUTPUT BY FEEDBACK CONTROL OF ULTRASONIC WAVE

APPARATUS FOR THE TREATMENT OF BRAIN AFFECTIONS AND METHOD IMPLEMENTING THEREOF

The present invention relates to an apparatus for the treatment of a brain affection, which comprises at least one implantable generator (4) made of non-ferromagnetic material comprising a casing (7), an ultrasound generating treating device (11) positioned into said casing to induce brain affection treatment by emission of ultrasound waves, and means for fastening the implantable casing into the skull. The apparatus further comprises a power controller (PwC) to supply electricity to the treating device of the implantable generator and to set and control its working parameters, and connecting means (6) to connect the power controller and the treating device of the implantable generator. A method for treating a brain affection with such an apparatus is also disclosed.

Ultrasound-based neuromodulation system

A neuromodulation system including a catheter having a balloon along its distal end is disclosed in several embodiments. An ultrasound transducer positioned within an interior of the balloon can be selectively activated to emit acoustic energy radially outwardly in order to target nerve tissue and other portions of the subject anatomy. In some embodiments, the system is configured to be delivered over a guidewire.

System and method providing directional ultrasound therapy to skeletal joints

An ultrasound therapy system and method is provided that provides directional, focused ultrasound to localized regions of tissue within body joints, such as spinal joints. An ultrasound emitter or transducer is delivered to a location within the body associated with the joint and heats the target region of tissue associated with the joint from the location. Such locations for ultrasound transducer placement may include for example in or around the intervertebral discs, or the bony structures such as vertebral bodies or posterior vertebral elements such as facet joints. Various modes of operation provide for selective, controlled heating at different temperature ranges to provide different intended results in the target tissue, which ranges are significantly effected by pre-stressed tissues such as in-vivo intervertebral discs. In particular, treatments above 70 degrees C., and in particular 75 degrees C., are used for structural remodeling, whereas lower temperatures achieves other responses ...

THERAPEUTIC TISSUE MODULATION DEVICES AND METHODS

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. Systems, devices and methods for cooling energy delivery members are also provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery. 129.-. (canceled)30. An intraluminal ablation catheter comprising:a proximal manifold;an elongate shaft comprising at least one lumen,wherein the elongate shaft comprises a central longitudinal axis extending along its length;a first balloon coupled to a distal end portion of the elongate shaft,wherein the balloon is adapted to transition between a folded configuration and an expanded, unfolded configuration,wherein the balloon comprises four electrodes,wherein a first electrode and a second electrode of the four electrodes are located in a first circumferential cross-sectional plane along the balloon and are located in opposite quadrants from each other around the circumference of the balloon when the balloon is in the expanded, unfolded configuration,wherein a third electrode and a fourth electrode of the four electrodes are located within a second circumferential cross-sectional plane along the balloon and are located in opposite quadrants from each other around the circumference of the balloon when the balloon is in the expanded, unfolded configuration, wherein the second circumferential cross-sectional plane is axially offset from the first circumferential cross-sectional plane; andone or more orifices adapted to direct fluid jets toward at least one of the four electrodes.31. The ablation catheter of claim 30 , wherein the third electrode and the fourth electrode are in different quadrants than the first electrode and the second electrode.32. ...

CONTINUOUS SINGLE WIRE STEERABLE CATHETER

Magnetic stimulation device

Die Erfindung betrifft eine Vorrichtung (1) zur magnetischen Stimulation von Körperregionen (R) mit zumindest einer Magnetspule (2), welche mit einem Stimulator (3) verbunden ist, der einen Leistungsteil (4) zur Erzeugung an die zumindest eine Magnetspule (2) anzulegende elektrischer Impulse (I) aufweist, sodass das in der zumindest einen Magnetspule (2) erzeugte Magnetfeld (H) in der Körperregion (R) induzierbar ist, wobei eine Detektionseinheit (5) zur Detektion von Metallelementen (6) innerhalb der Körperregion (R), vorgesehen, und die Detektionseinheit (5) mit einer Anzeigeeinheit (7) und dem Stimulator (3) verbunden ist. Zur Vermeidung einer Induktion von Strömen in Implantaten oder dgl. innerhalb der behandelten Körperregion (R) ist eine Messeinrichtung (8) zur Erfassung der von der zumindest einen Magnetspule (2) aufgenommenen elektrischen Leistung (P) und eine Vergleichseinrichtung (9) zum Vergleich der aufgenommenen elektrischen Leistung (P) mit einem vorgegebenen Grenzwert (Pmax ...

Magnetic Stimulation Device

Die Erfindung betrifft eine Vorrichtung (1) zur magnetischen Stimulation von Regionen (R) eines menschlichen oder tierischen Körpers, mit zumindest einer Magnetspule (2), welche mit einem Stimulator (3) verbunden ist, der einen Leistungsteil (4) zur Erzeugung an die zumindest eine Magnetspule (2) anzulegende elektrischer Impulse (I) aufweist, sodass das in der zumindest einen Magnetspule (2) erzeugte Magnetfeld (H) in der Körperregion (R) induzierbar ist. Zur Vermeidung einer Induktion von Strömen in Implantaten oder dgl. innerhalb der behandelten Körperregion (R) ist eine Detektionseinheit (5) zur Detektion von Metallelementen (6) innerhalb der Körperregion (R), in welcher das Magnetfeld (H) induziert wird, vorgesehen, und die Detektionseinheit (5) mit einer Anzeigeeinheit (7) verbunden.

GER�T F�R THE RENALE NEURO MODULATION

Systems and methods for enhancing efficacy of ultrasound treatment

Embodiments are provided that enhance ultrasound efficacy by for example, high efficiency, signal measurement, calibration, and assurance systems with a control system radio-frequency (RE) driver configured to drive one or more focused ultrasound transducers. The RE driver can comprise one or more power amplifiers including one or more III-V semiconductors, (e.g., gallium nitride GaN, GaAs, GaSb, InP, InAs, InSb, InGaAs, AlSb, AlGaAs, and/or AlGaN) field-effect transistors to efficiently provide high power with distinct narrow-band RE signals over a wide frequency range. The RE driver can include a power measurement and/or calibration system to monitor the amplitude and phase of the RE signal output from the power amplifier and estimate the amount of RE power delivered to the ultrasound transducers.

Ultrasound guided opening of blood-brain barrier

A system for delivering drugs or other molecules to the brain comprises an ultrasound imaging transducer configured to image structures such as the circle of Willis within a patient's head by way of a low attenuation acoustic window. The system includes a processor configured to register the ultrasound images to previously obtained images which also include the structures. The system includes ultrasound transducer elements operable to deliver ultrasound energy to a target region to cause the blood brain barrier to open. The system may include a drug delivery system that may be operated to deliver a drug to the patient in coordination with opening the blood brain barrier. Coordinates of the target region relative to the ultrasound imaging transducer are determined using registration information.

DEVICE AND METHOD FOR PREVENTING AND TREATING A VASOSPASM

The invention relates to a device having a stent structure (2) for inserting into intracranial blood vessels (6) of the human or animal body, wherein the stent structure (2) has an expanded state, in which the stent structure is able to contact the inner wall of the blood vessel (6), and a compressed state, in which the stent structure can be moved through the blood vessel (6) within a microcatheter (4), wherein the stent structure (2) is connected to an insertion aid (3) and wherein the stent structure (2) is able to independently transition into the expanded state after release from the microcatheter (4), wherein the stent structure (2) has electrical conductors (13), by means of which electrical pulses, high-frequency pulses, or ultrasonic pulses can be applied to nerve fibers extending in the vessel wall of the blood vessel (6) in order to temporarily or permanently reduce the function of the nerve fibers and to prevent or treat a vasospasm.

INTERNAL ORGAN, INJURY AND PAIN TREATMENT

Ultrasound (US) apparatus and method for applying low energy US onto an internal tissue/organ, including a non-invasive US appliance used on a treatment region over the internal tissue/organ, and an electrical stimulation appa ratus for simultaneously inducing interferential electrical stimulation. A controller controls parameters of the electrical stimulation apparatus and the US appliance, and dynamically changes at least one of the parameters, for maintaining the impedance of the body tissue in the treatment region within an impedance range. T he US apparatus includes an impedance monitoring apparatus for continuously measuring, tracking, and monitoring impedance in the treatment region, wherein the controller dynamically changes at least one of the parameter in response to the impedance as monitored, for maintaining the impedance within the predefined range. The internal tissue/organ can be a female fertility organ, which can be, an ovarian follicle, a blood vessel of the uterus (womb ...

METHOD AND APPARATUS FOR PERFORMANCE OF THERMAL BRONCHIPLASTY WITH UNFOCUSED ULTRASOUND

Apparatus and methods for deactivating bronchial nerves and smooth muscle extending along a bronchial branch of a mammalian subject to treat asthma and related conditions. An electromechanical transducer (11) is inserted into the bronchus as, for example, by advancing the distal end of a catheter (10) bearing the transducer into the bronchial section to be treated. The electromechanical transducer emits unfocused mechanical vibratory energy of one or more ultrasonic frequencies so as to heat tissues throughout a relatively large target region (13) as, for example, at least about 1 cm3 encompassing the bronchus to a temperature sufficient to inactivate nerves but insufficient to cause rapid ablation or necrosis of organic tissues. The treatment can be performed without locating or focusing on individual bronchial nerves.

IMMUNE SYSTEM NEUROMODULATION AND ASSOCIATED SYSTEMS AND METHODS

Methods for treating a patient using therapeutic immune system neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including modulating nerves proximate a vessel or duct of an immune system organ using an intravascularly or intraluminally positioned therapeutic element. One or more measurable physiological parameters corresponding to an immune system disorder, a condition associated with sympathetic activity in an immune system organ, or a condition associated with central sympathetic activity in the patient can thereby be reduced.

Vorrichtungen zur renalen Neuromodulation

Vorrichtung, eingerichtet zur renalen Neuromodulation, beispielsweise zur renalen Denervierung, und umfassend: einen Katheter, welcher ausgelegt ist, in einer Nierenarterie angeordnet und darin stabilisiert zu werden, wobei der Katheter einen distalen expandierbaren Abschnitt aufweist, welcher aus einer Zuführungskonfiguration mit geringem Querschnitt in Kontakt mit einer Innenwand der Nierenarterie expandiert werden kann, und eine Elektrode oder mehrere Elektroden, die an dem distalen expandierbaren Abschnitt angeordnet und ausgelegt sind, die Innenwand der Nierenarterie physisch zu kontaktieren ohne einen Nierennerv physisch zu kontaktieren, um in einer Behandlungszone der Nierenarterie Energie zuzuführen, um eine Neuromodulation, beispielsweise eine Denervierung, des Nierennervs zu bewirken.

Internal organ, injury and pain treatment

ULTRASOUND APPARATUS FOR MECHANICALLY APPLYING ULTRASOUND WAVES EFFICIENTLY

The present invention relates to an ultrasound apparatus for efficiently applying ultrasound waves over a treated area by mechanically moving the ultrasound transducer over an area larger than the Effective Radiating Area (ERA) comprising: (a) an ultrasound transducer, connected by wiring, for dispersing ultrasound waves; (b) an electric actuator for spinning a crank, wherein a shaft is eccentrically attached to said crank for rotatably whirling said transducer in circles.

SYSTEM AND METHOD FOR MEASURING AND CORRECTING ULTRASOUND PHASE DISTORTIONS INDUCED BY ABERRATING MEDIA

A system and method for efficiently transmitting and receiving focused ultrasound through a medium, such as bone, is provided. The focal region of the focused ultrasound is iteratively updated to provide an improved focus through the medium. This method may be carried out using a transducer assembly that includes two or more transmit arrays each operating at a different frequency. An initial focus is set and updated by delivering focused ultrasound with a lower frequency transmit array. The phase corrections determined in the first iteration are applied to subsequently higher frequency transmit arrays and received signals, and the process repeated until a desired focus or image resolution is achieved.

CONTINUOUS SINGLE WIRE STEERABLE CATHETER

A steerable catheter includes a body portion, a flexible catheter body with a proximal end and a distal tip and a continuous steering wire passing through the flexible body from the proximal end to the distal tip and turning back through the flexible body from the distal tip to the proximal end.

OCULAR PROBE ULTRASONIC TREATMENT

La présente invention concerne une sonde de traitement d'une pathologie oculaire comprenant : ○ un anneau (1) incluant un tronc de cône (11) ayant une première extrémité (111) adaptée pour supporter des moyens de génération d'ultrasons (2) et une deuxième extrémité (112) pour venir en contact avec un œil (4) d'un patient, ○ des moyens de génération d'ultrasons (2) comportant une première base (211) destinée à venir en regard de la première extrémité (111), et une deuxième base (212) opposée à la première base (211), remarquable en ce que la sonde comprend en outre régulateur de débit (3) pour supprimer les bulles contenues dans un fluide de couplage s'écoulant vers la première base (211) lors du remplissage de la sonde avec ledit fluide.

implantes que utilizam ondas ultrassônicas para estimular o tecido

CONSCIOUS ANIMAL ULTRASONIC NEURAL REGULATION DEVICE

Provided is a conscious animal ultrasonic neural regulation device, including a pulse signal generation module, a transducer module and a fixing module. The pulse signal generation module is configured to generate a pulse signal with high energy. The ultrasonic transducer module is configured to convert the pulse signal into an ultrasound. The fixing module includes an upper fixing module and a lower fixing module. The upper fixing module is configured to fix the ultrasonic transducer module, and the lower fixing module is configured to be fixed on an animal neural regulation target point. The upper fixing module and the lower fixing module are connected by a connecting component. The conscious animal neural regulation device of the present disclosure can perform accurate ultrasonic stimulation on a cerebral cortex and subcortex of the animal, thereby exploring and verifying the stimulation effect of the ultrasound on the animal, which is easy in operation and convenient in use.

BRAIN TO BRAIN INTERFACE SYSTEM APPLIED TO SINGLE BRAIN

A brain to brain interface system has a brain activity detection device configured to detect activity state information of a brain, a brain stimulation device configured to stimulate an area of at least a part of the brain to activate or inactivate brain cells of the corresponding area, and a computer configured to control the brain activity detection device and the brain stimulation device, wherein brain activity state information of a subject's brain (“a target brain”) is obtained through the brain activity detection device, and an area of at least a part of the target brain is stimulated through the brain stimulation device based on the brain activity state information of the target brain to regulate a function of the target brain.

IMPLANTS USING ULTRASONIC BACKSCATTER FOR RADIATION DETECTION AND ONCOLOGY

Described herein is an implantable device comprising a radiation-sensitive element (such as a transistor) configured to modulate a current as a function of radiation exposure to the transistor; and an ultrasonic device comprising an ultrasonic transducer configured to emit an ultrasonic backscatter that encodes the radiation exposure to the transistor. Further described herein is an implantable device comprising a radiation-sensitive element (such as a diode) configured to generate an electrical signal upon encountering radiation; an integrated circuit configured to receive the electrical signal and modulate a current based on the received electrical signal; and an ultrasonic transducer configured to emit an ultrasonic backscatter based on the modulated current encoding information relating to the encountered radiation. Further described are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic ...

Systems and methods for stimulating cellular function in tissue

The invention generally relates to systems and methods for stimulating cellular function in biological tissue. In certain embodiments, the invention provides a method for stimulating cellular function within tissue that involves providing a first type of energy to a region of tissue, in which the first type is provided in an amount that inhibits cellular function within the region of tissue, and providing a second type of energy to the region of tissue, in which the second type is provided in an amount that facilitates cellular function within the region of tissue, wherein the combined effect stimulates cellular function within the tissue.

Catheter-based devices and associated methods for immune system neuromodulation

Catheter-based devices and associated methods for immune system neuromodulation of human patients are disclosed herein. One aspect of the present technology is directed to methods of treating a human patient diagnosed with an immune system condition. The methods can include intravascularly positioning a neuromodulation catheter within a blood vessel proximate to neural fibers innervating an immune system organ of the patient. The method also includes reducing sympathetic neural activity in the patient by delivering energy to the neural fibers innervating the immune system organ via the neuromodulation catheter. Reducing sympathetic neural activity improves a measurable physiological parameter corresponding to the immune system condition of the patient.

INTRAVASCULAR ENERGY DELIVERY

A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.

Implants using ultrasonic waves for stimulating tissue

Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal. Further described are computer systems useful for operating ...

Neuronavigation-guided focused ultrasound system and method thereof

The present invention discloses a neuronavigation-guied focused ultrasound system and a method for the same, which are used to guide focused ultrasound energy to a target point. The system of the present invention comprises a focused ultrasound device, a neuronavigation system and a fixture. According to an image of an interested region of an individual, a focus point of the focused ultrasound device, and tracking points provided by the neuronavigation system, the neuronavigation system performs a calibration process and establishes a positional relationship between the focus point and the image of the interested region. Thereby, the neuronavigation system can recognize the focus point and guide focused ultrasound to the target point.

Neuromodulation systems having nerve monitoring assemblies and associated devices, systems, and methods

Neuromodulation systems with nerve monitoring assemblies and associated devices, systems, and methods are disclosed herein. A neuromodulation system configured in accordance with some embodiments of the present technology can include, for example, a generator, a nerve monitoring assembly configured to detect electroneurogram (ENG) signals, and a neuromodulation catheter. The neuromodulation catheter can include an elongated shaft with a distal portion and a proximal portion. The distal portion of the shaft can include an array of electrodes configured to detect nerve activity from within a blood vessel of a human. The proximal portion of the shaft can include at least one connector that operably couples the electrodes to the generator and to the nerve monitoring assembly.

HAND-HELD BATTERY-OPERATED THERAPEUTIC ULTRASONIC DEVICE

The present invention is a portable hand-held battery-operated therapeutic ultrasonic device that is specifically designed for clinical applications in muscle and joint pain management. The present invention generates stepwise high resolution, high frequency microprocessor-based signal to drive piezo-crystals for applying on the skin of the user. It makes use of a novel electronic driving technology that enables it to generate therapeutically combinations of acoustic intensities from 0 to 2 W/ cm2 and with 80-85% efficiency. It is a lightweight device and can be programmed wirelessly by a physician/professional to be used at home by a patient.

APPARATUS FOR THE TREATMENT OF BRAIN AFFECTIONS AND METHOD IMPLEMENTING THEREOF

The present invention relates to an apparatus for the treatment of a brain affection, which comprises at least one implantable generator (4) made of non-ferromagnetic material comprising a casing (7), an ultrasound generating treating device (11) positioned into said casing to induce brain affection treatment by emission of ultrasound waves, and means for fastening the implantable casing into the skull. The apparatus further comprises a power controller (PwC) to supply electricity to the treating device of the implantable generator and to set and control its working parameters, and connecting means (6) to connect the power controller and the treating device of the implantable generator. A method for treating a brain affection with such an apparatus is also disclosed.

System and method for measuring and correcting ultrasound phase distortions induced by aberrating media

Optimization of ultrasound frequency and microbubble size in microbubble enhanced ultrasound therapy

Systems and methods for optimizing transskull acoustic treatment

Ultrasound device for treatment of intervertebral disc tisssue

An ultrasound device and method for the treatment of intervertebral disc tissue for remediation of back pain. An applicator comprises a catheter and/or needle with a distal tip including one or more ultrasound transducer crystals. The crystals produce high-powered ultrasound energy that is transmitted and absorbed in the disc tissue. The resulting temperature elevation of the disc tissue shrinks the collagen fibers in the surrounding tissue, and/or destroying small nerves that may have invaded and innervated the surrounding degenerated tissue, and can provide increased structural integrity and disc support for the fragmented nucleus pulposus to relieve pressure on the spinal nerves.

CATHETER AND METHOD FOR USE

Tissue ablation systems and methods of using the same are disclosed. The tissue ablation systems can have an ultrasound ablation device connected to a catheter. The ultrasound ablation device can have a first conical reflector having a first reflective surface and a second conical reflector having a second reflective surface. The distance between the first and second conical reflectors can be adjusted, e.g., increased and/or decreased, to adjust the radial and/or longitudinal dimension of a focal zone from the device.

Catheters with enhanced flexibility and associated devices, systems, and methods

A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions.

SYSTEMS AND METHODS FOR USING LOW INTENSITY ULTRASONIC TRANSDUCER ON THE BRAIN

Methods, devices, and systems are disclosed for affixing and orienting an ultrasound transducer to a patient. A mount has a base, with a top surface, a bottom surface, an outer surface, and a plurality of internal surfaces. Some of the internal surfaces define a number of through holes that pass through the top surface and the bottom surface at the periphery or outer edge of the base. A number of supports are also arranged on the outer surface of the housing to affix the mount to the patient, to affix the transducer to the mount, or both. At least one of the plurality of internal surfaces defines a channel between the top and bottom surfaces proximal to a center of the mount, which receives a transducer and directs the transducer head toward the patient.

IMPLANTABLE ULTRASOUND GENERATING TREATING DEVICE FOR SPINAL CORD AND/OR SPINAL NERVE TREATMENT, APPARATUS COMPRISING SUCH DEVICE AND METHOD

An implantable ultrasound generating treating device (12) to induce spinal cord or spinal nerves treatment, suitable for implantation in the spinal canal and comprises an elongate support member (22, 32) and an array of several treatment transducers (20) distributed along the elongate support member. The several treatment transducers (20) comprise radial transducers emitting an ultrasound treatment beam oriented radially, wherein the treatment transducers (20) have a resonant frequency comprised between 0.5 and 4 MHz. The device has articulating portions so that the implantable device can adapt its shape to a curved elongation path. Also disclosed is an apparatus including the implantable ultrasound generating treating device and methods comprising inserting the implantable ultrasound generating treating device (12) inside the spinal canal of the spine of the patient.

УЛЬТРАЗВУКОВАЯ РАМА ДЛЯ ГОЛОВЫ ДЛЯ ЭКСТРЕННОЙ МЕДИЦИНСКОЙ ПОМОЩИ

... 1. Рама для головы, сконфигурированная для головы терапевтического больного, содержащая:опору для зонда, выполненного с возможностью формирования изображений, терапии или как формирования изображений, так и терапии; иопору для затылка (110), имеющую жесткую конструкцию, при этом опора для затылка выполнена с возможностью контакта с шеей пациента и для обеспечения жесткой опоры для шеи,при этом рама имеет конструкцию (113), которая обхватывает голову.2. Рама для головы по п. 1, дополнительно выполненная возможностью: 1) поддержки зонда на стороне головы (106) и 2) поддержки на противоположной стороне другого зонда, при этом обхватывание проходит вокруг одной стороны головы, противоположной стороне головы и затылка.3. Рама для головы по п. 1, в которой опора для затылка выполнена как отдельная часть рамы (100), при этом опора для затылка не прикреплена или если прикреплена, то с возможностью отсоединения к структуре, предоставляющей указанную опору для зонда.4. Рама для головы по п. 1, в ...

MAGNETIC STIMULATION DEVICE

The invention relates to a device (1) for magnetic stimulation of body regions (R), comprising at least one magnetic coil (2) connected to a stimulator (3), which has a power element (4) for generating electrical impulses (I) to be applied to the at least one magnetic coil (2), so that the generated magnetic field (H) can be induced in the body region (R), wherein a detection unit (5) is provided for detecting metal elements (6) within the body region (R). In order to prevent an induction of currents in implants or similar within the treated body region (R), a measuring device (8) is provided for detecting the electrical power (P) received by the magnetic coil (2) and a comparison device (9) is provided for comparing the power (P) with a predetermined limit value (Pmax), the detection unit (5) is connected to the stimulator (3), and the comparison unit (9) is designed to automatically switch off the stimulator (3) or reduce the power of the stimulator (3) or of the power element (4) of ...

IMPLANTS USING ULTRASONIC BACKSCATTER FOR DETECTING ELECTROPHYSIOLOGICAL SIGNALS

Described herein are implantable devices configured to detect an electrophysiological signal. Certain exemplary implantable devices comprise a first electrode and a second electrode configured to engage a tissue and detect an electrophysiological signal; an integrated circuit comprising a multi-transistor circuit and a modulation circuit configured to modulate a current based on the electrophysiological signal; and an ultrasonic transducer configured to emit an ultrasonic backscatter encoding the electrophysiological signal from the tissue based on the modulated current. Also described herein are systems that include one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Further described are computer systems for operating one or more implantable devices, and methods of detecting an electrophysiological ...

ACOUSTIC WINDOW FOR IMAGING ET/OU LE BRAIN TISSUE

ULTRASOUND HEAD FRAME FOR EMERGENCY MEDICAL SERVICES

A head frame is configured for the head of a medical patient (108) and includes support for a probe and a neck support. The frame wraps around said head, and can be used in the supine position. The support may include a probe holder (116) slidable under the head and to contact or engage the neck support. In some embodiments, conformal shaping to the head and/or neck, the frame's rigid construction, the alignment of the optionally separable holder to the neck support(110), and weight of the head all serve to keep the distal tip of the ultrasound probe in place against the temporal region of the head, without need for attaching the frame to the head as by straps, providing an arrangement robust against patient/vehicle movement in an emergency medical services setting. Head immobilizing walls may be folded away (316) in some versions, retaining probe alignment. In the holder, an optional circular opening with a spherical cross-section allows the probe(s) to be rotated into position, and X-Y-Z ...

APPARATUS FOR THE TREATMENT OF BRAIN AFFECTIONS AND METHOD IMPLEMENTING THEREOF

The present invention relates to an apparatus for the treatment of a brain affection, which comprises at least one implantable generator (4) made of non-ferromagnetic material comprising a casing (7), an ultrasound generating treating device (11) positioned into said casing to induce brain affection treatment by emission of ultrasound waves, and means for fastening the implantable casing into the skull. The apparatus further comprises a power controller (PwC) to supply electricity to the treating device of the implantable generator and to set and control its working parameters, and connecting means (6) to connect the power controller and the treating device of the implantable generator. A method for treating a brain affection with such an apparatus is also disclosed.

IMPLANTS USING ULTRASONIC BACKSCATTER FOR SENSING PHYSIOLOGICAL CONDITIONS

Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure. 1. A system , comprising: a sensor configured to detect an amount of an analyte; and', 'an ultrasonic transducer with a length of 5 mm or less in the longest dimension, the ultrasonic transducer configured to receive ultrasonic waves that power the implantable device, receive a current modulated based on the amount of the analyte detected by the sensor, and emit an analyte-amount-dependent ultrasonic backscatter based on the current received by the ultrasonic transducer; and, '(a) an implantable device, comprising(b) an interrogator comprising one or more ultrasonic transducers configured to transmit the ultrasonic waves that power the implantable device, and receive the ultrasonic backscatter from the implantable device.2. The system of claim 1 , wherein the analyte is oxygen.3. The system of claim 1 , wherein the analyte is glucose.4. The system of claim 1 , wherein the sensor is an optical sensor.5. The system of claim 4 , wherein the optical sensor comprises a light source and an optical detector.6. The system of claim 4 , wherein the optical sensor ...

SYSTEMS AND METHODS FOR MODULATNG NERVES OR OTHER TISSUE

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.

ADJUSTABLE HEADPIECE WITH ANATOMICAL MARKERS AND METHODS OF USE THEREOF

The invention generally relates to an adjustable headpiece with anatomical markers and methods of use thereof. In certain embodiments, the invention provides an apparatus that includes a headpiece configured to be worn on a head of a user. The headpiece includes at least a first receptacle configured to receive and retain a first energy source, and the headpiece is adjustable in at least one direction. There is at least one anatomical marker coupled to the headpiece. In that manner, a position of the receptacle can be adjustably aligned to a region of neural tissue in the head based on an alignment of the at least one anatomical marker with its designated anatomical structure. 1. An apparatus comprising:a headpiece configured to be worn on a head of a user and comprising at least a first receptacle configured to receive and retain a first energy source, the headpiece being adjustable in at least one direction; andat least one anatomical marker coupled to the headpiece so that a position of the receptacle can be adjustably aligned to a region of neural tissue in the head based on an alignment of the at least one anatomical marker with its designated anatomical structure.2. The apparatus according to claim 1 , further comprising the first energy source.3. The apparatus according to claim 1 , wherein the headpiece is adjustable in a plurality of different directions.4. The apparatus according to claim 3 , wherein the headpiece is adjustable in a vertical direction and a horizontal direction.5. The apparatus according to claim 1 , the apparatus comprises a plurality of anatomical markers claim 1 , each marker being coupled to the headpiece.6. The apparatus according to claim 5 , wherein at least two of the markers are arranged about the headpiece to be perpendicular to each other.7. The apparatus according to claim 6 , wherein at least two of the markers are arranged about the headpiece to be 180 degrees with respect to each other.8. The apparatus according to claim 1 , ...

УЛЬТРАЗВУКОВАЯ РАМА ДЛЯ ГОЛОВЫ ДЛЯ ЭКСТРЕННОЙ МЕДИЦИНСКОЙ ПОМОЩИ

Группа изобретений относится к медицинской технике, а именно к средствам для экстренной медицинской помощи. Рама для головы, сконфигурированная для головы терапевтического больного, содержит держатель зонда, содержащий по меньшей мере одно отверстие для удержания зонда, выполненного с возможностью формирования изображений или проведения терапии, или как формирования изображений, так и проведения терапии, и опору для затылка, имеющую жесткую конструкцию, при этом опора для затылка выполнена с возможностью контакта с шеей пациента и для обеспечения жесткой опоры для шеи, при этом держатель зонда имеет конструкцию, которая обхватывает голову без прикрепления держателя зонда к голове, и причем опора для затылка является отдельной от держателя зонда деталью или прикреплена к держателю зонда с возможностью отсоединения. Устройство формирования изображения содержит раму для головы. Использование группы изобретений позволяет удовлетворить требованиям об удержании зондов у головы пациента для надежного ...

SYSTEMS AND METHODS FOR ENHANCING EFFICACY OF ULTRASOUND TREATMENT

Embodiments are provided that enhance ultrasound efficacy by for example, high efficiency, signal measurement, calibration, and assurance systems with a control system radio-frequency (RE) driver configured to drive one or more focused ultrasound transducers. The RE driver can comprise one or more power amplifiers including one or more III-V semiconductors, (e.g., gallium nitride GaN, GaAs, GaSb, InP, InAs, InSb, InGaAs, AlSb, AlGaAs, and/or AlGaN) field-effect transistors to efficiently provide high power with distinct narrow-band RE signals over a wide frequency range. The RE driver can include a power measurement and/or calibration system to monitor the amplitude and phase of the RE signal output from the power amplifier and estimate the amount of RE power delivered to the ultrasound transducers.

A DEVICE FOR ULTRASONIC-ACCELERATED HEMATOMA LYSIS OR THROMBOLYSIS OF INTRACEREBRAL OR INTRAVENTRICULAR HERMORRHAGES OR HEMATOMAS

The present invention relates to a device for ultrasonic-accelerated hematoma lysis or thrombolysis of intracerebral or intraventricular hemorrhages or hematomas, comprising a body (20) which accommodates a number of separated compartments or lumens consisting of a flushing catheter (1) for flushing fluid and/or pharmaceutically active substances into the intracerebral or intraventricular hemorrhages or hematomas, a drainage catheter (2) for draining fluid from the intracerebral or intraventricular hemorrhages or hematomas, an ultrasonic probe duct (3), and a pressure sensor duct (5), wherein the compartments or lumens are arranged in proximity to each other and wherein in longitudinal extension at least upper-part sections of the compartments or lumens are isolated by walls, wherein the lumen of the pressure sensor duct (5) integrates a pressure sensor (6), and wherein in the lumen of ultrasonic probe duct (3) an endosonographic probe (4) or a stiletto (13) is interchangeably guided.

IMPLANTS USING ULTRASONIC WAVES FOR STIMULATING TISSUE

Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal. Further described are computer systems useful for operating ...

NEURONAVIGATION-GUIDED FOCUSED ULTRASOUND SYSTEM AND METHOD THEREOF

The present invention discloses a neuronavigation-guied focused ultrasound system and a method for the same, which are used to guide focused ultrasound energy to a target point. The system of the present invention comprises a focused ultrasound device, a neuronavigation system and a fixture. According to an image of an interested region of an individual, a focus point of the focused ultrasound device, and tracking points provided by the neuronavigation system, the neuronavigation system performs a calibration process and establishes a positional relationship between the focus point and the image of the interested region. Thereby, the neuronavigation system can recognize the focus point and guide focused ultrasound to the target point.

OCULAR PROBE ULTRASONIC TREATMENT

METHOD FOR TRANSIENTLY DISRUPTING A REGION OF THE BLOOD-BRAIN BARRIER OF A HUMAN

The present invention relates to a method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasounds in the presence of an ultrasound contrast agent, and uses thereof. The method comprises the application of at least one ultrasound (US) beam with a pressure level higher than 1 MPa and a resonance frequency ranging from 0.5 to 1.5 MHz. 1. A method for transiently disrupting a region of the blood-brain barrier (BBB) of a human using ultrasound in the presence of an ultrasound contrast agent , said method comprising the application to the brain of the patient of at least one ultrasound (US) beam with a pressure level higher than 1 MPa and a resonance frequency ranging from 0.5 to 1.5 MHz.2. The method of claim 1 , wherein the pressure level of the US beam is comprised between 1.1 MPa and 2.00 MPa claim 1 , or between 1.1 and 1.9 MPa claim 1 , or between 1.1 and 1.5 MPa.3. The method of claim 1 , wherein the applied US beam has a mechanical index (MI) of approximately from 1 to 2.00.4. The method of claim 1 , wherein the US beam is applied in pulses of duration about 25 ms and a pulse repetition frequency of about 1 Hz.5. The method of claim 1 , wherein the US of the US beams are focused US or unfocused US.6. The method of claim 1 , wherein the dose of ultrasound contrast agent administered to the human is approximately 0.1 ml/kg with a maximum dose of up to 8.7 ml.7. The method of claim 1 , comprising the application to the brain of the patient of US beam with a pressure level comprised between 1.1 and 1.9 MPa claim 1 , in pulses of duration about 25 ms and with a pulse repetition frequency of about 1 Hz.8. The method of claim 1 , comprising a former step consisting of implanting a US transducer within a burr hole in the skull of the human claim 1 , the US beam being applied with the US transducer.9. The method of claim 7 , comprising a former step consisting of implanting a US transducer within a burr hole in the skull of the ...

Immune system neuromodulation and associated systems and methods

Methods for treating a patient using therapeutic immune system neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including modulating nerves proximate a vessel or duct of an immune system organ using an intravascularly or intraluminally positioned therapeutic element. One or more measurable physiological parameters corresponding to an immune system disorder, a condition associated with sympathetic activity in an immune system organ, or a condition associated with central sympathetic activity in the patient can thereby be reduced.

Immune system neuromodulation and associated systems and methods

Methods for treating a patient using therapeutic immune system neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including modulating nerves proximate a vessel or duct of an immune system organ using an intravascularly or intraluminally positioned therapeutic element. One or more measurable physiological parameters corresponding to an immune system disorder, a condition associated with sympathetic activity in an immune system organ, or a condition associated with central sympathetic activity in the patient can thereby be reduced.

Neuromodulation systems having nerve monitoring assemblies and associated devices, systems, and methods

Neuromodulation systems with nerve monitoring assemblies and associated devices, systems, and methods are disclosed herein. A neuromodulation system configured in accordance with some embodiments of the present technology can include, for example, a generator, a nerve monitoring assembly configured to detect electroneurogram (ENG) signals, and a neuromodulation catheter. The neuromodulation catheter can include an elongated shaft with a distal portion and a proximal portion. The distal portion of the shaft can include an array of electrodes configured to detect nerve activity from within a blood vessel of a human. The proximal portion of the shaft can include at least one connector that operably couples the electrodes to the generator and to the nerve monitoring assembly.

Method and apparatus for performance of thermal bronchiplasty with unfocused ultrasound

Apparatus and methods for deactivating bronchial nerves and smooth muscle extending along a bronchial branch of a mammalian subject to treat asthma and related conditions. An electromechanical transducer (11) is inserted into the bronchus as, for example, by advancing the distal end of a catheter (10) bearing the transducer into the bronchial section to be treated. The electromechanical transducer emits unfocused mechanical vibratory energy of one or more ultrasonic frequencies so as to heat tissues throughout a relatively large target region (13) as, for example, at least about 1 cm3 encompassing the bronchus to a temperature sufficient to inactivate nerves but insufficient to cause rapid ablation or necrosis of organic tissues. The treatment can be performed without locating or focusing on individual bronchial nerves.

IMPLANTS USING ULTRASONIC BACKSCATTER FOR SENSING PHYSIOLOGICAL CONDITIONS

Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.

SYSTEMS AND METHODS FOR MODULATING NERVES OR OTHER TISSUE

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.

Implantable ultrasound generating treating device for brain treatment, apparatus comprising such device and method implementing such device

本发明涉及一种设备和一种可植入的超声发生治疗装置以及引起脑紊乱治疗，其适合于植入于患者的颅骨中或下方，且包括可通过共同电连接电路连接到发生器的若干超声发生换能器(20)，且其中所述超声发生换能器(20)各自具有一个或若干操作频率，其特征在于所述换能器至少包括：其特征在于所述组换能器由通过同一电驱动信号驱动且通过共同电连接电路连接到所述发生器系统的若干换能器组成，其中所述电驱动信号充当电力信号以及用于在所述组内选择性操作第一换能器或第一子组换能器以及第二换能器或第二子组换能器中的至少一者或另一者的控制信号。

METHOD FOR THE TREATMENT OF A BRAIN TISSUE

APPARATUS AND METHOD FOR DETERMINING OPTIMAL POSITIONS OF A HIFU PROBE

An apparatus for determining optimal positions of a mobile HIFU probe adapted for treating a target region (24), the apparatus comprising: a mobile probe; a central unit comprising a memory and a processor, said memory stores a database of probe positions and images of an insonificated region (105) separating the probe from the target region (24); said processor segments said image in order to identify a set of tissues and boundaries, evaluates a score for each probe position of the database, based on the set of tissues and boundaries, the score being indicative of an ultrasound energy loss along the path of ultrasound between the probe and the target region (24), and identify optimal probe positions which minimizes said ultrasound energy loss according to said scores.

NERVE MODULATION DEVICES AND RELATED METHODS

A nerve modulation device includes a first ultrasound transducer and a second ultrasound transducer. The first and second ultrasound transducers are configured to emit a first and second ultrasound waves, respectively, that exhibit different frequencies. The first and second ultrasound transducers can emit the first and second ultrasound waves in directions that are selected to cause the first and second ultrasound waves to intersect with each other at an intersection site that is at or near a selected nerve. At the intersection site, the first and second ultrasound waves can non-linearly interact to form an acoustic wave exhibiting a frequency that is less than the frequencies of the first and second ultrasound waves. The acoustic wave can modulate a selected nerve.

Infusion system and method for sonothrombolysis stroke treatment

An infusion system for sonothrombolysis treatment uses a syringe loaded with a microbubble solution and operated by a syringe pump to deliver the microbubble solution to a subject during sonothrombolysis treatment. To prevent the stratification of the microbubble solution in the barrel of the syringe during treatment, the barrel also contains a plurality of magnetic beads which are agitated into semi-random patterns of motion in the syringe chamber during the procedure. The magnetic beads are moved by magnetic attraction and repulsion from the moving magnets of a magnetic stirrer mounted in proximity to the syringe during treatment.

System for denervation

An apparatus for vascular denervation, comprising a catheter configured for delivery into a vessel of a patient. A balloon is mounted on a distal tip of the catheter, the balloon being configured to be inflatable and further configured so that, upon inflation, the balloon adopts a shape that includes a first edge and a second edge that wind around each other in a double helix, the first edge and the second edge being separated from each other by a first crease and a second crease that also wind around each other in a double helix. A first electrode is attached to the balloon and is located to extend along the first edge.

Methods and apparatus for renal neuromodulation

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

Systems and methods for modulating nerves or other tissue

According to various embodiments, systems, devices and methods for modulating targeted nerve fibers (e.g., hepatic neuromodulation) or other tissue are provided. The systems may be configured to access tortuous anatomy of or adjacent hepatic vasculature. The systems may be configured to target nerves surrounding (e.g., within adventitia of or within perivascular space of) an artery or other blood vessel, such as the common hepatic artery.

IMPLANTABLE ULTRASOUND GENERATING DEVICE FOR IMPLANTATION WITHIN A VERTEBRAL COLUMN

The present invention relates to an implantable ultrasound (US) generating device for implantation within the vertebral column of a vertebrate subject, wherein the implantable US generating device comprises at least one US generating transducer suitable for emitting US beam(s) with an oblique orientation with respect to a longitudinal axis of a vertebral column.

IMPLANTABLE ULTRASOUND GENERATING TREATING DEVICE FOR BRAIN TREATMENT, APPARATUS COMPRISING SUCH DEVICE AND METHOD IMPLEMENTING SUCH DEVICE

The present invention relates to an apparatus and an implantable ultrasound generating treating device and to induce brain disorder treatment, suitable for implantation in or under the skull bone of a patient, and comprising several ultrasound generating transducers (20) which are connectable by a common electrical connection circuit to a generator, and wherein the ultrasound generating transducers (20) each have one or several operating frequencies, characterized in that the transducers comprise at least: characterized in that the group of transducers consists of several transducers driven by a same electrical drive signal, and connected to the generator system by a common electrical connection circuit, where the electric drive signal serves both as power signal and as a control signal for operating selectively, within said group, at least one or the other of a first transducer or sub-group of transducers, and of a second transducer or sub-group of transducers.

THERAPEUTIC DEVICE BASED ON THE PRINCIPLE OF A BIOFEEDBACK BY TRANSMITTING ELECTROMAGNETIC WAVES IN FREQUENCIES CORRECTIVE PRERECORDED STIMULATES AN ACCURATE BRAIN AREA

ASSEMBLY FOR IMAGING AND/OR TREATING A BRAIN TISSUE

ULTRASONIC ENERGY DISPLAY DEVICE

Ultrasound device for treatment of intervertebral disc tissue

An ultrasound device and method for the treatment of intervertebral disc tissue for remediation of back pain. An applicator comprises a catheter and/or needle with a distal tip including one or more ultrasound transducer crystals. The crystals produce high-powered ultrasound energy that is transmitted and absorbed in the disc tissue. The resulting temperature elevation of the disc tissue shrinks the collagen fibers in the surrounding tissue, and/or destroying small nerves that may have invaded and innervated the surrounding degenerated tissue, and can provide increased structural integrity and disc support for the fragmented nucleus pulposus to relieve pressure on the spinal nerves.

Systems and methods for stimulating cellular function in tissue

The invention generally relates to systems and methods for stimulating cellular function in biological tissue. In certain embodiments, the invention provides a method for stimulating cellular function within tissue that involves providing a first type of energy to a region of tissue, in which the first type is provided in an amount that inhibits cellular function within the region of tissue, and providing a second type of energy to the region of tissue, in which the second type is provided in an amount that facilitates cellular function within the region of tissue, wherein the combined effect stimulates cellular function within the tissue.

Methods and devices for modulating cellular activity using ultrasound

The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities. Devices of the present invention comprise one or more components for generating ultrasound waves, such as ultrasonic emitters, transducers or piezoelectric transducers, composite transducers, CMUTs, and which may be provided as single or multiple transducers or in an array configurations. The ultrasound waves may be of any shape, and may be focused or unfocused.

Focused ultrasound guiding system and method thereof

The present invention discloses a neuronavigation-guided focused ultrasound system and a method for the same, which are used to guide focused ultrasound energy to a target point. The system of the present invention comprises a focused ultrasound device, a neuronavigation system and a fixture. According to an image of an interested region of an individual, a focus point of the focused ultrasound device, and tracking points provided by the neuronavigation system, the neuronavigation system performs a calibration process and establishes a positional relationship between the focus point and the image of the interested region. Thereby, the neuronavigation system can recognize the focus point and guide focused ultrasound to the target point.

INTEGRATED SYSTEM FOR ULTRASOUND IMAGING AND THERAPY

Ultrasound imaging and therapy with the same array of capacitive micromachined ultrasonic transducers is provided. The electronics includes a per-pixel switch for each transducer element. The switches provide an imaging mode driven completely by on-chip electronics and a therapy mode where off-chip pulsers provide relatively high voltages to the transducer elements.

CRANIAL IMPLANT DEVICES, SYSTEMS, AND RELATED METHODS

Devices, systems, and methods for specializing, monitoring, and/or evaluating therapeutic nasal neuromodulation

Devices, systems, and methods for specializing, monitoring, and/or evaluating therapeutic nasal neuromodulation are disclosed herein. A targeted neuromodulation system configured in accordance with embodiments of the present technology can include, for example, an evaluation/modulation assembly at a distal portion of a shaft and including a plurality of electrodes. The electrodes are configured to emit stimulating energy at frequencies for identifying and locating target neural structures and detect the resultant bioelectric properties of the tissue. The system can also include a console that maps locations of the target neural structures. The evaluation/modulation assembly can then apply therapeutic neuromodulation energy in a highly tailored neuromodulation pattern based on the mapped locations of the target neural structures. Accordingly, the system provides therapeutic neuromodulation to highly specific target structures while avoiding non-target structures to reduce collateral effects ...

Device and method for preventing and treating a vasospasm

The invention relates to a device having a stent structure (2) for inserting into intracranial blood vessels (6) of the human or animal body, wherein the stent structure (2) has an expanded state, in which the stent structure is able to contact the inner wall of the blood vessel (6), and a compressed state, in which the stent structure can be moved through the blood vessel (6) within a microcatheter (4), wherein the stent structure (2) is connected to an insertion aid (3) and wherein the stent structure (2) is able to independently transition into the expanded state after release from the microcatheter (4), wherein the stent structure (2) has electrical conductors (13), by means of which electrical pulses, high-frequency pulses, or ultrasonic pulses can be applied to nerve fibers extending in the vessel wall of the blood vessel (6) in order to temporarily or permanently reduce the function of the nerve fibers and to prevent or treat a vasospasm.

TREATING DEGENERATIVE DEMENTIA WITH LOW INTENSITY FOCUSED ULTRASOUND PULSATION (LIFUP) DEVICE

Ultrasonic energy is used for treating degenerative dementia. A focal point of an ultrasonic transducer beam is directed at a target area of the brain to promote removal of substances that accumulate in the interstitial pathways that are at least partially responsible for the degenerative dementia. In one example, the target area of the brain may comprise the hippocampus and the degenerative dementia may be Alzheimer's disease. The ultrasonic beam may stimulate brain tissue at a frequency that corresponds to a naturally occurring deep sleep burst frequency of neurons and subsequent astrocyte activation patterns that drive a convective process responsible for brain solute disposal. For example, the transducer may generate a burst frequency of between 1-4 hertz to stimulate deep sleep brain functions that help remove amyloid plaque.

APPARATUS FOR THE TREATMENT OF BRAIN AFFECTIONS AND METHOD IMPLEMENTING THEREOF

The present invention relates to an apparatus for the treatment of a brain affection, which comprises at least one implantable generator (4) made of non-ferromagnetic material comprising a casing (7), an ultrasound generating treating device (11) positioned into said casing to induce brain affection treatment by emission of ultrasound waves, and means for fastening the implantable casing into the skull. The apparatus further comprises a power controller (PwC) to supply electricity to the treating device of the implantable generator and to set and control its working parameters, and connecting means (6) to connect the power controller and the treating device of the implantable generator. A method for treating a brain affection with such an apparatus is also disclosed.

MAGNETIC STIMULATION DEVICE

The invention relates to a device (1) for magnetic stimulation of body regions (R), comprising at least one magnetic coil (2) connected to a stimulator (3), which has a power element (4) for generating electrical impulses (I) to be applied to the at least one magnetic coil (2), so that the generated magnetic field (H) can be induced in the body region (R), wherein a detection unit (5) is provided for detecting metal elements (6) within the body region (R). In order to prevent an induction of currents in implants or similar within the treated body region (R), a measuring device (8) is provided for detecting the electrical power (P) received by the magnetic coil (2) and a comparison device (9) is provided for comparing the power (P) with a predetermined limit value (Pmax), the detection unit (5) is connected to the stimulator (3), and the comparison unit (9) is designed to automatically switch off the stimulator (3) or reduce the power of the stimulator (3) or of the power element (4) of ...

Methods and apparatus for neuromodulation

A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform.

IMPLANTS USING ULTRASONIC BACKSCATTER FOR SENSING PHYSIOLOGICAL CONDITIONS

Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.

SYSTEMS AND METHODS FOR SYMPATHETIC CARDIOPULMONARY NEUROMODULATION

Methods, devices and systems are described for decreasing the activity of the sympathetic nervous innervation to and from the lungs and the vessels supplying the lungs to treat pulmonary medical conditions such as asthma. In one embodiment, the method may involve advancing an intravascular instrument to a target location in a blood vessel within the intercostal vasculature to ablate either or both the sympathetic afferent and efferent nerves lying within the paravertebral gutter including the visceral fibers that travel to the cardiothoracic cavity and abdominopelvic viscera and the T1 to T4/5 sympathetic chain. In another embodiment, an intravascular instrument may be advanced to the bronchial vessels to ablate either or both the sympathetic afferent and efferent nerves in and around the posterior pulmonary plexus. In one embodiment the ablative agent is a neurolytic agent delivered in a gel. This approach may be utilized to treat other cardiac and pulmonary diseases.

ULTRASOUND-BASED NEUROMODULATION SYSTEM

A neuromodulation system including a catheter has a balloon along its distal end. An ultrasound transducer positioned within an interior of the balloon can be selectively activated to emit acoustic energy radially outwardly, targeting nerve tissue and other portions of the subject anatomy. Targeted nerve tissue can be heated by the application of ultrasonic energy to neuromodulate the tissue. The system may be delivered over a guidewire. A catheter enhances fluid delivery to a distal end of the catheter while reducing an overall diameter of the catheter. The catheter comprises a guidewire lumen that is eccentric relative to a center axis of the catheter.

AN EYE PROBE FOR TREATMENT WITH ULTRASONIC WAVES

The present invention concerns a probe for treating an ocular pathology, comprising: o a ring () including a cone frustum () having a first end () suitable for supporting ultrasound generation means () and a second end () for coming into contact with an eye () of a patient, o ultrasound generation means () comprising a first base () intended to come to face the first end (), and a second base () opposite the first base (), remarkable in that the probe further comprises a flow regulator () for eliminating the bubbles contained in a coupling fluid flowing to the first base () when filling the probe with said fluid. 1. A probe for treating an eye pathology comprising:a ring including a truncated cone having a first end adapted for supporting means for generating ultrasonic waves and a second end for coming into contact with an eye of a patient,means for generating ultrasonic waves including a first base intended to come to face the first endue, and a second base opposed to the first base, anda flow rate regulator for suppressing the bubbles contained in a coupling fluid flowing towards the first base during the filling of the probe with said fluid.2. The probe according to claim 1 , whereinthe ring comprises a skirt coaxial with the truncated cone, andthe means for generating ultrasonic waves comprising a crown, the skirt extending outwards from the first end so as to surround the crown.3. The probe according to claim 2 , wherein the regulator comprises an aperture defined between the skirt and the crown claim 2 , said aperture extending over the whole height of the crown for allowing passing of the fluid between the second and first bases.4. The probe according to claim 3 , wherein the aperture extends over the whole perimeter of the crown.5. The probe according to wherein the thickness of the aperture is comprised between 0.1 mm and 5 mm claim 3 , preferentially between 0.2 and 2 mm claim 3 , and still more preferentially equal to 0.5 mm.6. The probe according to ...

ULTRASOUND-MEDIATED NEUROSTIMULATION

Various approaches to stimulating neural activity in one or more target regions associated with one or more brain diseases or disorders include transmitting the first sequence of ultrasound pulses to the target region(s); measuring a physiological parameter indicative of the neural activity at the target region(s) resulting from the ultrasound pulses; and based at least in part on the measurement, adjusting a parameter value associated with one or more transducer elements so as to achieve a target objective of the neural activity. 1. A system for stimulating neural activity in at least one target region associated with at least one brain disease or disorder using focused ultrasound , the system comprising:an ultrasound transducer comprising a plurality of transducer elements; and (a) transmit a first sequence of ultrasound pulses to the target region;', '(b) cause measurements of a physiological parameter indicative of the neural activity at the target region resulting from the ultrasound pulses; and', '(c) based at least in part on the measurements, adjust a first parameter value associated with at least one of the transducer elements so as to achieve a target objective of the neural activity., 'a controller configured to2. The system of claim 1 , further comprising a monitoring system for measuring the physiological parameter at the target region.3. The system of claim 2 , wherein the monitoring system comprises at least one of a fMRI claim 2 , ASL MRI claim 2 , EEG or fNIRS.4. The system of claim 1 , wherein the physiological parameter comprises at least one of a change in a blood flow or a change in a chemical in tissue at the target region.5. The system of claim 1 , wherein the controller is further configured to:cause the sequence of ultrasound pulses to create a focus at the target region;cause measurements of a temperature at the focus; andbased at least in part on the measured temperature, adjust a second parameter value associated with at least one of the ...

NEUROMODULATION ENERGY APPLICATION TECHNIQUES

SIMULATION-BASED DRUG TREATMENT PLANNING

Ischemic Stroke Therapy

A method for delivering ultrasound energy to a patient's intracranial space includes the steps of forming a hole in a patient's skull, locating an ultrasound transmitter near or into the hole, and transmitting ultrasound from the transmitter into the intracranial space, wherein the Mechanical Index of ultrasound energy traveling through cerebral tissue in the intracranial space is less than 1.0, the power intensity delivered to a target tissue in the intracranial space is greater than 50 mW/cm 2 and less than 200 mW/cm 2 , and the frequency of the transmitted ultrasound is within the range between 500 kHz and 2 MHz. Microbubbles, aspirin, both microbubbles and aspirin, and a mixture of microbubbles and aspirin, can also be delivered into the intracranial space.

Reflectance-facilitated ultrasound treatment and monitoring

Apparatus comprising an ultrasound ablation system ( 10 ), which comprises a reflection-facilitation element ( 12 ), configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultra-sound tool ( 20 ), which comprises at least one ultrasound transducer ( 40 ) configured to be positioned within a heart chamber of the subject. The ultrasound transducer ( 40 ) is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.

NEURONAVIGATION-GUIDED FOCUSED ULTRASOUND SYSTEM AND METHOD THEREOF

The present invention discloses a neuronavigation-guided focused ultrasound system and a method for the same, which are used to guide focused ultrasound energy to a target point. The system of the present invention comprises a focused ultrasound device, a neuronavigation system and a fixture. According to an image of an interested region of an individual, a focus point of the focused ultrasound device, and tracking points provided by the neuronavigation system, the neuronavigation system performs a calibration process and establishes a positional relationship between the focus point and the image of the interested region. Thereby, the neuronavigation system can recognize the focus point and guide focused ultrasound to the target point. 1. A neuronavigation-guided focused ultrasound system , which guides a focused ultrasound energy to a target point , comprisinga focused ultrasound device generating a focus point and delivering said energy to said target point;a neuronavigation system electrically connecting with said focused ultrasound device and including a calibration unit, wherein said calibration unit establishes a positional relationship between said focus point and an image of a interested region of an individual, performs a calibration process on coordinates, and enables said neuronavigation system to recognize said focus point and define said target point; anda fixture fixing said interested region of said individual.2. The neuronavigation-guided focused ultrasound system according to claim 1 , wherein said focused ultrasound device further comprisesa signal generator generating an ultrasonic signal;a signal amplifier electrically connecting with said signal generator and amplifying said ultrasonic signal into said focused ultrasound; andan ultrasonic transducer electrically connecting with said signal amplifier, delivering said focused ultrasound to said target point, wherein a central frequency of said focused ultrasound resonates with said ultrasonic ...

Methods and apparatus for renal neuromodulation

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

Integrated System for Ultrasound Imaging and Therapy using Per-Pixel Switches

Ultrasound imaging and therapy with the same array of capacitive micromachined ultrasonic transducers is provided. The electronics includes a per-pixel switch for each transducer element. The switches provide an imaging mode driven completely by on-chip electronics and a therapy mode where off-chip pulsers provide relatively high voltages to the transducer elements.

METHOD FOR STIMULATING, AND APPARATUSES PERFORMING THE SAME

Disclosed is a method and apparatus for more locally stimulating a desired stimulation region in a predetermined part of an object, the apparatus including a first ultrasonic wave generator configured to output a first ultrasonic beam to a predetermined part of an object, a second ultrasonic wave generator configured to output a second ultrasonic beam to the predetermined part of the object, and a controller configured to control the first ultrasonic wave generator and the second ultrasonic wave generator such that central axes of the first ultrasonic wave generator and the second ultrasonic wave generator are disposed on the same plane, and a crossing angle between the first ultrasonic beam and the second ultrasonic beam is a predetermined angle. 1. A stimulating apparatus , comprising:a first ultrasonic wave generator configured to output a first ultrasonic beam to a predetermined part of an object;a second ultrasonic wave generator configured to output a second ultrasonic beam to the predetermined part of the object; anda controller configured to control the first ultrasonic wave generator and the second ultrasonic wave generator such that central axes of the first ultrasonic wave generator and the second ultrasonic wave generator are disposed on the same plane, and a crossing angle between the first ultrasonic beam and the second ultrasonic beam is a predetermined angle.2. The stimulating apparatus of claim 1 , wherein the controller is configured to control an arrangement position of at least one of the first ultrasonic wave generator and the second ultrasonic wave generator such that focus points of the first ultrasonic wave generator and the second ultrasonic wave generator match.3. The stimulating apparatus of claim 2 , wherein the controller is configured to control an output intensity of at least one of the first ultrasonic wave generator and the second ultrasonic wave generator such that intensities of the first ultrasonic beam and the second ultrasonic ...

METHOD AND APPARATUS FOR PREVENTING LOCALIZED STASIS OF CEREBROSPINAL FLUID

A system and method for treating, inhibiting or ameliorating Alzheimer's disease in a patient, comprising one or more transducers operatively connected to a power source for radiating vibrational or acoustical energy to the maxilla of the patient, wherein the energy is sufficient to radiate through the paranasal sinuses of the patient to the base of the patient's skull to assist in cerebrospinal fluid clearance and inhibit localized stasis of cerebrospinal fluid in the brain. 1. A method for treating , inhibiting or ameliorating localized stasis of cerebrospinal fluid in the brain of a patient , comprising administering vibrational or acoustical energy to the maxilla of the patient , wherein the energy is sufficient to radiate through the paranasal sinuses of the patient to the base of the patient's skull to assist in cerebrospinal fluid clearance and inhibit localized stasis of cerebrospinal fluid in the brain.2. The method according to claim 1 , wherein the vibrational or acoustical energy is administered to the maxilla via one or more transducers operatively connected to a power source.3. The method according to claim 2 , wherein the one or more transducers radiate energy to one or more upper teeth of the patient.4. The method according to claim 2 , further comprising inserting a mouthpiece over the patient's upper teeth or upper jaw claim 2 , wherein the one or more transducers are disposed on the mouthpiece and direct vibrational or acoustical energy to the patient's upper teeth or upper jaw.5. The method according to claim 2 , wherein the one or more transducers are ultrasonic transducers.6. The method according to claim 2 , wherein the one or more transducers are sonic transducers.7. The method according to claim 2 , wherein the one or more transducers are supersonic transducers.8. The method according to claim 2 , wherein the transducer is releasably connected to an implant disposed in the maxilla of the patient.9. The method according to claim 2 , further ...

Devices and methods for optimized neuromodulation and their application

Disclosed are methods and systems for optimized deep or superficial deep-brain stimulation using multiple therapeutic modalities impacting one or multiple points in a neural circuit to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Also disclosed are methods for treatment of clinical conditions and obtaining physiological impacts. Also disclosed are: methods and systems for Guided Feedback control of non-invasive deep brain or superficial neuromodulation; patterned neuromodulation, ancillary stimulation, treatment planning, focused shaped or steered ultrasound; methods and systems using intersecting ultrasound beams; non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier; non-invasive neuromodulation of the spinal cord by ultrasound energy; methods and systems for non-invasive neuromodulation using ultrasound for evaluating the feasibility of neuromodulation treatment using non-ultrasound/ultrasound modalities; neuromodulation of the whole head, treatment of multiple conditions, and method and systems for neuromodulation using ultrasound delivered in sessions.

ULTRASOUND DEVICE FOR FACILITATING WASTE CLEARANCE OF THE BRAIN LYMPHATIC SYSTEM

An ultrasound device for facilitating waste clearance of the brain lymphatic system includes: a first frequency-generator generating a predetermined frequency; a first waveform modulator modulating a waveform of the frequency; a first linear amplifier amplifying the waveform; a first resonance circuit portion matching impedance of the amplified waveform; and a first ultrasound transducer coupled to the first resonance circuit portion and irradiating ultrasound toward the area of the brain of mammals, wherein the ultrasound facilitates clearance of lymphatic wastes of the brain. 1. An ultrasound device for facilitating lymphatic waste clearance of a brain lymphatic system , comprising:a first frequency-generator generating a first frequency that is of an ultrasound waveform in a band of 100 KHz to 200 KHz;a first waveform modulator modulating the waveform of the first frequency;a first linear amplifier amplifying the waveform of the first frequency;a first resonance circuit portion matching impedance of the amplified waveform of the first frequency; anda first ultrasound transducer coupled to the first resonance circuit portion and irradiating ultrasound toward a brain of mammals,wherein the ultrasound facilitates the lymphatic waste clearance of the brain.2. The ultrasound device according to claim 1 , further comprising:a second frequency-generator generating a second frequency that is of an ultrasound waveform in a band of 100 KHz to 200 KHz;a second waveform modulator modulating a waveform of the second frequency;a second linear amplifier amplifying the waveform of the second frequency;a second resonance circuit portion matching impedance of the amplified waveform of the second frequency; anda second ultrasound transducer coupled to the second resonance circuit portion and irradiating the ultrasound toward the brain of the mammals,wherein the first ultrasound transducer and the second ultrasound transducer are disposed in a circumference of the brain facing ...

PHYSIOLOGICAL MONITORING FOR ULTRASOUND THERAPY

In some examples, a system includes a flexible ultrasound device configured to be attached to an external surface of a patient proximate to an organ of the patient to deliver ultrasound configured to modulate nerve tissue of the patient at the organ. The system further comprises one or more sensors configured to sense one or more physiological parameters indicative of at least one of a symptom treatable by, or a side effect of, the neuromodulation, and processing circuitry configured to control the delivery of ultrasound during an ambulatory period of the patient, and monitor the least one of the symptom or the side effect during the ambulatory period, based on the one or more physiological parameters. The organ may be the spleen and the ultrasound may at least one of regulate the autoimmune system of the patient, or reduce an inflammation response of the patient. 1. A system comprising: a flexible interconnect element;', 'a plurality of ultrasound transducers connected to the flexible interconnect element;', 'one or more power sources connected to the flexible interconnect element; and', 'signal generation circuitry powered by the one or more power sources and connected to the flexible interconnect element, wherein the signal generation circuitry is configured to generate a signal that drives one or more of the ultrasound transducers to deliver an ultrasound signal to the organ, the ultrasound signal configured to modulate nerve tissue of the patient at the organ;, 'a flexible ultrasound device configured to be attached to an external surface of a patient proximate to an organ of the patient, wherein the flexible ultrasound device comprisesone or more sensors configured to sense one or more physiological parameters of the patient, the one or more physiological parameters indicative of at least one of a symptom treatable by the modulation of the nerve tissue of the patient at the organ, or a side effect of the modulation of the nerve tissue of the patient at the ...

Methods and Apparatus for Neuromodulation

A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform. 1. An apparatus comprising:(a) one or more sensors that are configured to measure a physiological signal; (i) to calculate a discrete signal that consists of samples of the physiological signal,', '(ii) to calculate a second signal, which second signal is a discrete Fourier transform of the discrete signal,', '(iii) to calculate a smoothed signal, by performing calculations that include (A) applying a causal filter to the second signal, which causal filter deforms a front-segment but not an end-segment of the second signal in such a way that the start point of the smoothed signal is equal in value to the endpoint of the smoothed signal, and (B) removing negative frequency components,', '(iv) to calculate an analytic signal, which analytic signal is equal to an inverse discrete Fourier transform of the smoothed signal,', '(v) to calculate, based on the analytic signal, instantaneous phase of the physiological signal, and', '(vi) to output instructions, based on the instantaneous phase; and, '(b) one or more computers that are programmed'}(c) one or more ...

Methods and Apparatus for Neuromodulation

A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform. 2. The method of claim 1 , wherein the physiological signal is an electrical signal.3. The method of claim 1 , wherein the physiological signal is motion caused by a physiological tremor.4. The method of claim 1 , wherein the calculations include computing a discrete Fourier transform of the periodic discrete signal and then applying a causal filter to the discrete Fourier transform.5. The method of claim 1 , wherein the calculations include:(a) front-padding the periodic discrete signal with a copy of an end segment of the periodic discrete signal to create a padded signal;(b) then applying a causal filter to the padded signal; and(c) then removing a front segment of the padded signal.6. The method of claim 1 , wherein the signal that affects the activity of neural tissue is phase-coordinated with the physiological signal.8. The apparatus of claim 7 , wherein the physiological signal is an electrical signal.9. The apparatus of claim 7 , wherein the physiological signal is motion caused by a physiological tremor.10. The apparatus of claim 7 , wherein the ...

Implants using ultrasonic backscatter for sensing physiological conditions

Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.

Internal Organ, Injury and Pain, Pulmonary Condition and Adipose Tissue Treatment

Ultrasound (US) apparatus and method for applying low energy US onto an internal tissue/organ, including a non-invasive US appliance used on a treatment region over the internal tissue/organ, and an electrical stimulation apparatus for simultaneously inducing interferential electrical stimulation. A controller controls parameters of the electrical stimulation apparatus and the US appliance, and dynamically changes at least one of the parameters, for maintaining the impedance of the body tissue in the treatment region within an impedance range. The US apparatus includes an impedance monitoring apparatus for continuously measuring, tracking, and monitoring impedance in the treatment region, wherein the controller dynamically changes at least one of the parameter in response to the impedance as monitored, for maintaining the impedance within the predefined range. The internal tissue/organ can be a female fertility organ which can be an ovarian follicle, a blood vessel of the uterus (womb), the ovary, the endometrial lining, and the Fallopian tube; a lung, a pulmonary organ, an adipose tissue, ulcer, closed wound, internal injury, inflammation. and nerves. 1. Ultrasound (US) apparatus for applying low energy US onto an internal tissue/organ , comprising:(a) a non-invasive external US appliance operational for applying low energy US energy, at an US frequency and an US intensity, onto a treatment region over the internal tissue/organ;(b) an electrical stimulation apparatus comprising two pairs of electrodes operational for inducing interferential electrical stimulation configured for positioning at crossed configuration onto the skin at the treatment region in proximity to the internal tissue/organ, by applying, simultaneously with said applying US energy, a first current at a first electric frequency and a first electric intensity via one of said two pairs of electrodes, and a second current at a second electric frequency and a second electric intensity via another of ...

METHODS AND SYSTEMS FOR PERIPHERAL NERVE MODULATION USING FOCUSED ULTRASOUND

Techniques for modulating peripheral nerves using focused ultrasound (FUS) are provided. Methods include locating a peripheral nerve in a subject using an imaging probe, providing a FUS having one or more ultrasound parameters to a location on the peripheral nerve, and modulating the peripheral nerve. The methods can further include eliciting and measuring a physiological response from the FUS modulation, generating tissue deformation in the vicinity of the FUS modulation, and imaging the nerve and the tissue deformation simultaneously with FUS modulation. Systems for use in the modulation of peripheral nerves are also provided. 1. A method for modulation of a peripheral nerve in a subject using a focused ultrasound (FUS) assembly having one or more ultrasound parameters , comprising:adjusting the one or more ultrasound parameters to adapt a FUS for a location on the peripheral nerve; andmodulating the peripheral nerve with the FUS.2. The method of claim 1 , further comprising locating the peripheral nerve using an imaging probe prior to adjusting the one or more ultrasound parameters.3. The method of claim 1 , wherein the peripheral nerve comprises a sciatic nerve claim 1 , a tibial nerve claim 1 , or a sacral nerve.4. The method of claim 1 , wherein the FUS assembly comprises a high intensity focused ultrasound (HIFU) transducer with a 3.57 MHz center frequency claim 1 , a 0.46×3.55 mm focal area and a 35 mm focal depth claim 1 , a 20 MHz function waveform generator claim 1 , and a 150 W amplifier.5. The method of claim 1 , wherein the one or more ultrasound parameters comprise at least one of a peak negative pressure claim 1 , a stimulation duration claim 1 , a duty cycle claim 1 , and a pulse repetition frequency (PRF).6. The method of claim 5 , wherein the peak negative pressure is from about 1.1 MPa to about 8.8 MPa.7. The method of claim 5 , wherein the stimulation duration is from about 0.8 ins to about 1 s.8. The method of claim 5 , wherein the duty cycle ...

Transcranial ultrasound focusing

The invention introduces a system for focusing ultrasonic energy through intervening tissue into a target site within a target tissue region, includes a transducer emitter array, a transducer receiver array, a processor receiving echo signals from the receiver to determine correction factors for the transducer elements to compensate for refraction occurring due to intervening tissue. The correction factors may include phase correction factors, and the phases of excitation signals provided to the transducer elements may be adjusted based upon the phase correction factors to focus the ultrasonic energy to the tissue at the target site.

INTEGRATED SYSTEM FOR ULTRASOUND IMAGING AND THERAPY

Ultrasound imaging and therapy with the same array of capacitive micromachined ultrasonic transducers is provided. The electronics includes a per-pixel switch for each transducer element. The switches provide an imaging mode driven completely by on-chip electronics and a therapy mode where off-chip pulsers provide relatively high voltages to the transducer elements. 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. (canceled)9. (canceled)10. (canceled)11. An apparatus with a plurality of ultrasound modes , the apparatus comprising:an array of ultrasound transducer elements;imaging circuitry configured to perform ultrasound imaging with the array of ultrasound transducer elements in a first mode;a pulser configured to provide a voltage to an ultrasound transducer element of the array of ultrasound transducer elements in a second mode, wherein the array generates continuous wave ultrasound or quasi-continuous wave ultrasound in the second mode; anda switch configured to electrically connect the pulser to the ultrasound transducer of the array for the second mode and to electrically disconnect the pulser from the ultrasound transducer of the array for the first mode, the switch being on a chip, and the pulser being external to the chip such that power dissipation associated with the pulser occurs external to the chip.12. The apparatus of claim 11 , wherein the imaging circuitry is on the chip.13. The apparatus of claim 11 , further comprising:additional pulsers having phases spaced with each other; andadditional switches configured to electrically connect the additional pulsers to the array in the second mode and to electrically disconnect the additional pulsers from the array in the first mode.14. The apparatus of claim 11 , wherein the pulser has a fixed connection with the switch.15. The apparatus of claim 11 , further comprising a line switch configured to selectively electrically connect the pulser to the switch.16. The ...

NONINVASIVE ELECTRICAL TREATMENT DEVICES

Noninvasive neuromodulation combines transcutaneous electrical modulation with heat and/or focused ultrasonic energy. A noninvasive neuromodulation device includes a first bipole electrode pair aligned along a first axis and a second bipole electrode pair aligned along a second axis, the first axis and the second axis defining a plane. A focused ultrasound (FUS) transducer can direct a focused ultrasound beam along a third axis that intersects the plane. A controller is electrically coupled to the first and second bipole electrode pairs and to the focused ultrasound transducer. The controller is configured to apply electrical energy having a frequency of between about 1 Hz to about 100 MHz to the first and second bipole electrode pairs, and to cause the FUS transducer to emit a focused ultrasound beam having a frequency of between about 20 kHz to about 10 MHz. 177-. (canceled)78. A noninvasive electrical treatment device comprising:a first bipole electrode pair aligned along a first axis;a second bipole electrode pair aligned along a second axis, the first axis and the second axis defining a plane;a focused ultrasound (FUS) transducer configured to direct a focused ultrasound beam along a third axis that intersects the plane; apply electrical energy having a frequency of between about 1 Hz to about 100 MHz to the first and second bipole electrode pairs; and', 'cause the FUS transducer to emit a focused ultrasound beam having a frequency of between about 20 kHz to about 10 MHz., 'a controller electrically coupled to the first and second bipole electrode pairs and to the focused ultrasound transducer, the controller configured to79. The device of claim 78 , wherein the device is configured to be applied over a patient's head to apply the electrical energy to a treatment site in the patient's brain.80. The device of claim 78 , wherein the third axis intersects the plane at an angle greater than 45 degrees.81. The device of claim 78 , further comprising a third bipole ...

IMPLANTABLE ULTRASOUND GENERATING TREATING DEVICE FOR SPINAL CORD AND/OR SPINAL NERVE TREATMENT, APPARATUS COMPRISING SUCH DEVICE AND METHOD

An implantable ultrasound generating treating device () to induce spinal cord or spinal nerves treatment, suitable for implantation in the spinal canal and comprises an elongate support member () and an array of several treatment transducers () distributed along the elongate support member. The several treatment transducers () comprise radial transducers emitting an ultrasound treatment beam oriented radially, wherein the treatment transducers () have a resonant frequency comprised between 0.5 and 4 MHz. The device has articulating portions so that the implantable device can adapt its shape to a curved elongation path. Also disclosed is an apparatus including the implantable ultrasound generating treating device and methods comprising inserting the implantable ultrasound generating treating device () inside the spinal canal of the spine of the patient. 112- Implantable ultrasound generating treating device () to induce spinal cord or spinal nerves treatment by emission of ultrasound waves , wherein the ultrasound generating treating device is suitable for implantation in the spinal canal and comprises:{'b': 22', '32', '11, 'an elongate support member (, ) extending along an elongation path ();'}{'b': 20', '11, 'an array of several ultrasound generating treatment transducers () distributed along the elongate support member along an active portion on the elongation path ();'}{'b': 20', '20, 'wherein the several treatment transducers () comprise radial transducers, each radial treatment transducer () emitting an ultrasound treatment beam oriented radially with respect to the elongation path over an effective angular range of at least 120°, preferably at least 180° around the elongation path at the location of the radial transducer;'}{'b': '20', 'wherein the treatment transducers () have an ultrasound generating resonant frequency comprised between 0.5 and 4 MHz, and'}{'b': '25', 'wherein the device has articulating portions () along the active portion of the elongation ...

SYSTEMS AND METHODS FOR FAST AND REVERSIBLE NERVE BLOCK

One aspect of the present disclosure relates a system that can quickly and reversibly block conduction in a nerve. The system can include a first nerve block modality that provides heat to the nerve to block conduction in the nerve. For example, the heat can provide the quick nerve block. The system can also include a second nerve block modality that provides an electrical signal to the nerve to block the conduction in the nerve. For example, the electrical signal can provide the reversibility. In some instances, the heat can be provided by an infrared light signal and the electrical signal can be provided by a kilohertz frequency alternating current (KHFAC) signal or a direct current (DC) signal. 114-. (canceled)15. A neural prosthetic device , comprising:an optrode that provides heat to a nerve causing the spasticity to block conduction in a nerve; andan electrode that provides an electrical signal to the nerve to block the conduction in the nerve,wherein the heat is provided to the nerve to block conduction in the nerve during an onset response of the electrical signal.16. The neural prosthetic device of claim 15 , wherein the block of the conduction in the nerve controls spacticity in a muscle17. The neural prosthetic device of claim 15 , wherein the optrode and the electrode are combined in a single device.18. The neural prosthetic device of claim 15 , wherein the heat blocks conduction in the nerve within 1 second or less while blocking an onset response of the electrical signal; andwherein the electrical signal maintains the conduction block for at least one minute.19. The neural prosthetic device of claim 18 , wherein the conduction block is reversible within one second or less and does not damage a neural response of the nerve.20. The neural prosthetic device of claim 15 , wherein the stimulation component and the conduction block component are combined in a single device. This application claims the benefit of U.S. Provisional Application No. 61/954,915, ...

ULTRASOUND-INDUCED CONVECTION FOR DRUG DELIVERY AND TO DRIVE GLYMPHATIC OR LYMPHATIC FLOWS

The utility of intrathecal delivery is limited by the poor brain and spinal cord parenchymal uptake of intrathecally delivered agents. A simple noninvasive transcranial ultrasound protocol is provided that significantly increases the brain parenchymal uptake of intrathecally administered drugs and antibodies. This protocol of transcranial ultrasound can accelerate glymphatic fluid transport from the cisternal space into the parenchymal compartment. The low intensity and noninvasive approach of ultrasound in this protocol underscores the ready path to clinical translation of this technique. This low-intensity transcranial ultrasound protocol can be used to directly bypass the blood-brain barrier for whole-brain delivery of a variety of agents. Additionally, this protocol is useful as a means to probe the causal role of the glymphatic system in the variety of disease and physiologic processes to which it has been correlated. 1. A method of increasing brain penetration of an intrathecally administered agent , the method comprising:intrathecally administering an agent to a subject; andapplying transcranial ultrasound to the subject to modulate the glymphatic pathway to promote brain penetration of the intrathecally administered agent.2. The method of claim 1 , wherein the method comprises applying transcranial ultrasound across the whole brain of the subject.3. The method of claim 1 , wherein the transcranial ultrasound has a frequency ranging from 600 kHz to 700 kHz.4. The method of claim 1 , wherein the transcranial ultrasound has an intensity ranging from 10 mW/cmto 450 mW/cm.5. The method of claim 1 , wherein the transcranial ultrasound has a mechanical index ranging from 0.2 to 0.3.6. The method of claim 1 , wherein the transcranial ultrasound comprises transcranial focused ultrasound.7. The method of claim 1 , wherein the method comprises upregulating the glymphatic pathway.8. The method of claim 1 , wherein the agent has a molecular weight ranging from 1 kDa to ...

Methods for selective treatment of renal sympathetic nerves

The present invention is directed to device and method for electrically modulating the function of a sympathetic nerve that control sympathetic activity of the renal arteries in the human body. The method includes modifying neural fibers that regulate sympathetic activity of renal tissue to accentuate or attenuate function. The present invention also includes an apparatus for executing methods to regulate renal sympathetic activity via intravascular lumen.

ENERGY DELIVERY TO INTRAPARENCHYMAL REGIONS OF THE KIDNEY TO TREAT HYPERTENSION

A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall. 119-. (canceled)20. A method to apply energy to an intraparenchymal region of a kidney in a patient to ablate nerves inside the kidney , the method comprising:obtaining an image using an imager, the image having an image of a blood vessel;verifying that the blood vessel travels to a kidney by identifying the kidney in the image that has the image of the blood vessel;determining a target region which includes nerves around the blood vessel; andapplying pulses of energy to the target region;wherein a feature in the image is used as a fiducial during the application of the pulses of the energy to ensure that the pulses of energy are applied to the target region.21. The method of claim 20 , wherein the pulses of energy are delivered using a micro catheter placed inside an artery inside the kidney.22. The method of claim 21 , wherein the micro catheter is configured to apply radio frequency energy to the intraparenchymal region of the kidney.23. The method of claim 20 , wherein the pulses of energy are delivered from outside the patient using an ultrasound transducer.24. The method of claim 20 , wherein the pulses of energy are delivered using an intravascular catheter claim 20 , which is configured to apply ultrasound to the intraparenchymal region inside the kidney.25. The method of claim 20 , wherein the target region comprises a plurality of sub-target regions.26. The method of claim 20 , wherein the target region is at the cortex of the kidney27. The method of claim 20 , wherein the target region is at ...

Methods and Apparatus for Neuromodulation

A neuromodulator accurately measures—in real time and over a range of frequencies—the instantaneous phase and amplitude of a natural signal. For example, the natural signal may be an electrical signal produced by neural tissue, or a motion such as a muscle tremor. The neuromodulator generates signals that are precisely timed relative to the phase of the natural signal. For example, the neuromodulator may generate an exogenous signal that is phase-locked with the natural signal. Or, for example, the neuromodulator may generate an exogenous signal that comprises short bursts which occur only during a narrow phase range of each period of an oscillating natural signal. The neuromodulator corrects distortions due to Gibbs phenomenon. In some cases, the neuromodulator does so by applying a causal filter to a discrete Fourier transform in the frequency domain, prior to taking an inverse discrete Fourier transform. 1. A method comprising:(a) measuring a physiological signal;(b) calculating a discrete signal that comprises samples of the physiological signal;(c) calculating a second signal, which second signal is a discrete Fourier transform of the discrete signal;(d) calculating a smoothed signal, by performing calculations that include (i) applying a causal filter to the second signal, which causal filter deforms a front-segment but not an end-segment of the second signal in such a way that the start point of the smoothed signal is equal in value to the endpoint of the smoothed signal, and (ii) removing negative frequency components;(e) calculating a portion of an analytic signal, which analytic signal is equal to an inverse discrete Fourier transform of the smoothed signal;(f) calculating, based on said portion of the analytic signal, instantaneous phase of the physiological signal;(g) outputting instructions, based on the instantaneous phase; and(h) outputting a neuromodulation signal, based on the instructions.2. The method of claim 1 , wherein the physiological signal ...

CATHETERS WITH ENHANCED FLEXIBILITY AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS

A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions. 124-. (canceled)25. A neuromodulation catheter , comprising: a first helically wound elongate member at least partially forming a first tubular structure,', 'a second helically wound elongate member at least partially forming a second tubular structure concentrically disposed around the first tubular structure, wherein the second elongate member is counter-wound relative to the first elongate member, and', 'a third helically wound elongate member at least partially forming a third tubular structure concentrically disposed around the second tubular structure, wherein the third elongate member is counter-wound relative to the second elongate member; and, 'an elongate shaft including'}a neuromodulation element at a distal end portion of the shaft.26. (canceled)27. The neuromodulation catheter of wherein claim 25 ,the first elongate member includes first windings;the second elongate member includes second windings; anda difference between a helix angle of a given one of the first windings and a helix angle of a given one of the second windings nearest to the given one of the first windings decreases at successively more distal portions of the shaft.28. The neuromodulation catheter of wherein the shaft includes a biocompatible jacket at least partially encasing the first claim 25 , second claim 25 , and third tubular ...

ADJUSTABLE HEADPIECE WITH ANATOMICAL MARKERS AND METHODS OF USE THEREOF

The invention generally relates to an adjustable headpiece with anatomical markers and methods of use thereof. In certain embodiments, the invention provides an apparatus that includes a headpiece configured to be worn on a head of a user. The headpiece includes at least a first receptacle configured to receive and retain a first energy source, and the headpiece is adjustable in at least one direction. There is at least one anatomical marker coupled to the headpiece. In that manner, a position of the receptacle can be adjustably aligned to a region of neural tissue in the head based on an alignment of the at least one anatomical marker with its designated anatomical structure. 1. An apparatus comprising:a headpiece configured to be worn on a head of a user and comprising at least a first receptacle configured to receive and retain a first energy source, the headpiece being adjustable in at least one direction; andat least one anatomical marker coupled to the headpiece so that a position of the receptacle can be adjustably aligned to a region of neural tissue in the head based on an alignment of the at least one anatomical marker with its designated anatomical structure.2. The apparatus according to claim 1 , further comprising the first energy source.3. The apparatus according to claim 1 , wherein the headpiece is adjustable in a plurality of different directions.4. The apparatus according to claim 3 , wherein the headpiece is adjustable in a vertical direction and a horizontal direction.5. The apparatus according to claim 1 , the apparatus comprises a plurality of anatomical markers claim 1 , each marker being coupled to the headpiece.6. The apparatus according to claim 5 , wherein at least two of the markers are arranged about the headpiece to be perpendicular to each other.7. The apparatus according to claim 6 , wherein at least two of the markers are arranged about the headpiece to be 180 degrees with respect to each other.8. The apparatus according to claim 1 , ...

Neuromodulation systems having nerve monitoring assemblies and associated devices, systems, and methods

Neuromodulation systems with nerve monitoring assemblies and associated devices, systems, and methods are disclosed herein. A neuromodulation system configured in accordance with some embodiments of the present technology can include, for example, a generator, a nerve monitoring assembly configured to detect electroneurogram (ENG) signals, and a neuromodulation catheter. The neuromodulation catheter can include an elongated shaft with a distal portion and a proximal portion. The distal portion of the shaft can include an array of electrodes configured to detect nerve activity from within a blood vessel of a human. The proximal portion of the shaft can include at least one connector that operably couples the electrodes to the generator and to the nerve monitoring assembly.

CATHETERS WITH ENHANCED FLEXIBILITY AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS

A neuromodulation catheter includes an elongate shaft and a neuromodulation element. The shaft includes two or more first cut shapes and two or more second cut shapes along a helical path extending around a longitudinal axis of the shaft. The first cut shapes are configured to at least partially resist deformation in response to longitudinal compression and tension on the shaft and torsion on the shaft in a first circumferential direction. The second cut shapes are configured to at least partially resist deformation in response to longitudinal compression on the shaft and torsion on the shaft in both first and second opposite circumferential directions. 1. A neuromodulation catheter , comprising: two or more first cut shapes, the first cut shapes being configured to at least partially resist deformation in response to compression on the shaft along a longitudinal axis of the shaft, tension on the shaft along the longitudinal axis, and torsion on the shaft in a first circumferential direction perpendicular to the longitudinal axis, and', 'two or more second cut shapes, the second cut shapes being configured to at least partially resist deformation in response to compression on the shaft along longitudinal axis, torsion on the shaft in the first circumferential direction, and torsion on the shaft in a second circumferential direction opposite to the first circumferential direction; and, 'an elongate shaft including—'}a neuromodulation element operably connected to the shaft via a distal end portion of the shaft, the first and second cut shapes are interspersed along a helical path extending about the longitudinal axis,', 'the first cut shapes are less resistant to deformation in response to torsion on the shaft in the second circumferential direction than are the second cut shapes, and', 'the second cut shapes are less resistant to deformation in response to tension on the shaft along the longitudinal axis than are the first cut shapes., 'wherein—'}2. The ...

INTEGRATED SYSTEM FOR ULTRASOUND IMAGING AND THERAPY

Ultrasound imaging and therapy with the same array of capacitive micromachined ultrasonic transducers is provided. The electronics includes a per-pixel switch for each transducer element. The switches provide an imaging mode driven completely by on-chip electronics and a therapy mode where off-chip pulsers provide relatively high voltages to the transducer elements. 1. (canceled)2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. (canceled)9. (canceled)10. (canceled)11. An apparatus for ultrasonic imaging and therapy , the apparatus comprising:an array of transducer elements;imaging circuitry configured to perform ultrasound imaging with the array of transducer elements in an ultrasonic imaging mode;a pulser configured to provide a voltage to a transducer element of the array of transducer elements in an ultrasound therapy mode; andmode switching circuitry connected between the pulser and the transducer element, the mode switching circuitry configured to switch operation of the transducer element between the ultrasonic therapy mode and the ultrasonic imaging mode, the mode switching circuitry comprising transistors arranged to pass a voltage that is greater than a gate-to-source voltage of any one of the transistors.12. The apparatus of claim 11 , further comprising:one or more additional pulsers, wherein the pulser and the one or more additional pulsers are included in a plurality of pulsers; anda line switch configured to connect the mode switching circuitry to a selected one of the pulsers.13. The apparatus of claim 11 , wherein the transistors comprise a first transistor and a second transistor connected in series with each other claim 11 , and wherein the switch comprises a diode connected between a source and a gate of the first transistor claim 11 , the diode also being connected between a source and a gate of the second transistor.14. The apparatus of claim 11 , wherein the imaging circuitry and the mode switching circuitry are ...

IMPLANTS USING ULTRASONIC BACKSCATTER FOR SENSING PHYSIOLOGICAL CONDITIONS

Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure. 1. An implantable device , comprising:a sensor configured to detect an amount of an analyte, a pH, a temperature, a strain, or a pressure; andan ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive a current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current.2. The implantable device of claim 1 , wherein the ultrasonic transducer is configured to receive ultrasonic waves that power the implantable device.3. The implantable device of claim 2 , wherein the ultrasonic transducer is configured to receive ultrasonic waves from an interrogator comprising one or more ultrasonic transducers.4. The implantable device of claim 1 , wherein the ultrasonic transducer is a bulk piezoelectric transducer claim 1 , a piezoelectric micro-machined ultrasonic transducer (PMUT) or a capacitive micro-machined ultrasonic transducer (CMUT).5. The implantable device of claim 1 , wherein the implantable device ...

IV CATHETER INSERTION GUIDE

An IV catheter insertion guide is configured to reduce the pain a patient may experience during catheter insertion. The IV catheter insertion guide may include two platforms that can be positioned on opposing sides of the insertion site. An upstream platform can include an ultrasonic transducer or another type of heating component for increasing the temperature of tissue near the insertion site. This heating of the tissue can cause the targeted vessel to relax and increase its cross-sectional area prior to insertion of the catheter. A downstream platform can also include an ultrasonic transducer for stimulating nerves downstream from the insertion site during the insertion of the catheter. The stimulation of the downstream nerves may reduce the pain signal that is transmitted to the central nervous system in response to the catheter insertion.

FOCUSED ULTRASOUND FOR NON-INVASIVE FOCAL GENE DELIVERY TO THE MAMMALIAN BRAIN

Methods of employing non-oncolytic viruses or plasmids and focused ultrasound are provided. Specifically, the disclosure provides methods for ultrasound-mediated non-invasive delivery of gene therapy agents to the central nervous system, wherein magnetic resonance (MR) guided focused ultrasound is used, optionally in combination with microbubbles, to facilitate gene delivery to a particular region of the brain. 1. A non-invasive method to deliver a prophylactic or therapeutic transgene to one or more regions of a brain or spinal cord of a mammal , comprising: administering to a mammal in need thereof , an amount of a population of microbubbles and an amount of a non-oncolytic recombinant virus or a plasmid comprising the transgene; and applying to one or more regions of the central nervous system of the mammal focused ultrasound in an amount that provides for delivery of the recombinant virus or the plasmid to the one or more regions of the brain or spinal cord.2. The method of wherein the microbubbles comprise a mammalian serum protein.3. The method of wherein the mammal is a human.4. The method of further comprising administering a magnetic resonance imaging (MRI) contrast agent to the mammal.5. The method of wherein the microbubbles and the recombinant virus or the plasmid are concurrently administered.6. The method of wherein a composition comprising the microbubbles and the recombinant virus or the microbubbles and the plasmid is administered.7. The method of wherein the focused ultrasound is applied after the microbubbles and the recombinant virus or the plasmid are administered or wherein the focused ultrasound is applied concurrently with the administration of the microbubbles and the recombinant virus or the plasmid.810-. (canceled)11. The method of wherein the transgene encodes a protein claim 1 , a glycoprotein claim 1 , a miRNA claim 1 , or siRNA claim 1 , wherein the protein is optionally a recombinase.12. (canceled)13. The method of wherein the ...

Ischemic Stroke Therapy

A method for delivering ultrasound energy to a patient's intracranial space includes the steps of forming a hole in a patient's skull, locating an ultrasound transmitter near or into the hole, and transmitting ultrasound from the transmitter into the intracranial space, wherein the Mechanical Index of ultrasound energy traveling through cerebral tissue in the intracranial space is less than 1.0, the power intensity delivered to a target tissue in the intracranial space is greater than 50 mW/cmand less than 200 mW/cm, and the frequency of the transmitted ultrasound is within the range between 500 kHz and 2 MHz. Microbubbles, aspirin, both microbubbles and aspirin, and a mixture of microbubbles and aspirin, can also be delivered into the intracranial space, 1. A method for delivering ultrasound energy to a patient's intracranial space , comprising:forming a hole in a patient's skull;locating an ultrasound transmitter near he hole;transmitting ultrasound from the transmitter into the intracranial space, wherein:the Mechanical Index of ultrasound energy traveling through cerebral tissue in the intracranial space is less than 1.0; and{'sup': 2', '2, 'the power intensity delivered to a target tissue in the intracranial space is greater than 50 mW/cmand less than 200 mW/cm.'}2. The method of claim 1 , wherein the frequency of the transmitted ultrasound is within the range between 500 kHz and 2 MHz.3. The method of claim 1 , wherein the locating step includes the step of advancing the transmitter into the hole.4. The method of claim 1 , wherein after the locating step claim 1 , the method includes the step of delivering microbubbles into the intracranial space.5. The method of claim 1 , wherein after the locating step claim 1 , the method includes the step of delivering aspirin into the intracranial space.6. The method of claim 4 , wherein after the locating step claim 4 , the method includes the step of delivering aspirin into the intracranial space.7. The method of claim ...

Reflectance-facilitated ultrasound treatment and monitoring

Apparatus comprising an ultrasound ablation system, which comprises a reflection-facilitation element, configured to be placed at an extramyocardial site of a subject, and to provide an extramyocardial reflective region; and an ultrasound tool, which comprises at least one ultrasound transducer configured to be positioned within a heart chamber of the subject. The ultrasound transducer is configured to ablate myocardial tissue by applying ultrasound energy to the myocardial tissue such that at least a portion of the transmitted energy is reflected by the reflective region onto the myocardial tissue. Other embodiments are also described.

Immune system neuromodulation and associated systems and methods

Methods for treating a patient using therapeutic immune system neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to methods including modulating nerves proximate a vessel or duct of an immune system organ using an intravascularly or intraluminally positioned therapeutic element. One or more measurable physiological parameters corresponding to an immune system disorder, a condition associated with sympathetic activity in an immune system organ, or a condition associated with central sympathetic activity in the patient can thereby be reduced.

FLEXIBLE AND WEARABLE LONG DURATION ULTRASOUND DEVICE

The present invention generally relates to, inter alia, devices, methods, and systems for use in medical applications for humans and animals involving long duration ultrasound treatment. An ultrasound transducer array is provided that includes (i) a plurality of ultrasound transducers arranged in a matrix formation and operably coupled to an electrical network and (ii) a mesh structure securing the plurality of ultrasound transducers in the matrix formation, where each ultrasound transducer is connected to the electrical network in a manner sufficient to allow each ultrasound transducer to operate independent of one another or in unison. Ultrasound systems including the ultrasound transducer array and methods of using the ultrasound systems are also disclosed. 1. An ultrasound transducer array comprising:a. a plurality of ultrasound transducers arranged in a matrix formation and operably coupled to an electrical network; and 'wherein each ultrasound transducer is connected to the electrical network in a manner sufficient to allow each ultrasound transducer to operate independent of one another or in unison.', 'b. a mesh structure securing the plurality of ultrasound transducers in the matrix formation,'}2. The ultrasound transducer array according to claim 1 , wherein the array is configured to be flexible and wearable claim 1 , thereby being suitable for long duration ultrasound application to a subject.3. The ultrasound transducer array according to claim 1 , wherein said matrix formation comprises the plurality of ultrasound transducers oriented in substantially the same plane with their ultrasound emitting surfaces facing the same direction.4. (canceled)5. The ultrasound transducer array according to claim 1 , wherein said electrical network is configured to have redundant wiring.6. (canceled)7. The ultrasound transducer array according to claim 1 , wherein said electrical network is configured to have redundant wiring with each transducer in parallel to ...

Implants using ultrasonic waves for stimulating tissue

Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal. Further described are computer systems useful for operating one or more implantable devices, as well as methods of electrically stimulating a tissue.

METHOD FOR MINIMALLY INVASIVE SURGERY USING THERAPEUTIC ULTRASOUND TO TREAT SPINE AND ORTHOPEDIC DISEASES, INJURIES AND DEFORMITIES

A method for minimally invasive surgery using therapeutic ultrasound in spine and orthopedic orthopedic procedures. The method includes a minimally invasive access port, a therapeutic ultrasound probe to treat a targeted area through the port, and a protective sheath that enables application of the therapeutic ultrasound without causing unintended tissue damage. 1. A surgical device comprising: a tubular member; a connector at a proximal end of said tubular member; an outlet port for light energy provided in said tubular member at said distal end thereof; and a fiber-optic light guide embedded in said tubular member and extending to said outlet port.2. The surgical device defined in wherein said tubular member is provided with a connector configured for delivering light energy to an end of said fiber-optic light guide opposite said outlet.3. The surgical device defined in wherein said tubular member is part of a sheath for an ultrasonic surgical instrument claim 2 , said sheath including a proximal section and a distal section claim 2 , said distal section having a smaller transverse cross-section than a cross-section of said proximal section claim 2 , said connector being disposed on said proximal section at a point spaced from said distal section.4. The surgical device defined in claim 3 , further comprising an ultrasonic tool including a handpiece insertable into said proximal section and further including a small-diameter probe or horn insertable into said distal section.5. The surgical device defined in wherein said outlet port comprises a translucent element attached to said tubular member at said distal end thereof.6. The surgical device defined in wherein said translucent element is provided with a coating of paint over selected areas claim 5 , said coating of paint locking light transmission.7. The surgical device defined in wherein said translucent element is annular and is provided on a cylindrical outer surface with a reflective coating.8. A surgical ...

SYSTEMS AND DEVICES FOR COUPLING ULTRASOUND ENERGY TO A BODY

Methods and systems for coupling ultrasound to the body, including to the head, are disclosed. The system is optionally configured to transmit ultrasound energy for transcranial ultrasound neuromodulation. Couplant assemblies are described that incorporate a semi-solid component that interfaces directly to the user's body and face of the ultrasound transducer. These couplant assemblies can be shaped, molded, or otherwise machined and, in some embodiments, contain one or more liquid, gel, or other non-solid component in an enclosed reservoir of the couplant assembly. Beneficial embodiments of ultrasound coupling assemblies described herein include those that conform to the contour of the user's body (e.g. the user's head for transcranial applications) and can easily be removed without leaving a messy residue. By having solid materials physically contacting the body, no residue is left that requires cleanup. 1. A system for coupling ultrasound energy to a subject comprising:a couplant assembly to couple ultrasound energy from at least one ultrasound transducer to the subject.2. The system of claim 1 , wherein the couplant assembly comprises at least one conformable solid material in physical contact with the at least one transducer and wherein the couplant assembly comprises a conformable couplant material having a Shore D durometer hardness value of less than 60 D claim 1 , such that an outer surface of the couplant material deflects at least partially in response to a skin or hair of the user when placed in order to couple the at least one ultrasound transducer to the user.3. The system of claim 2 , wherein the couplant assembly comprises at least one liquid or gel material contained within the conformable solid material.4. The system of wherein the couplant assembly comprises a couplant structure claim 3 , the couplant structure comprising a plurality of components at least one of which comprises a conformable solid material to interface directly with the at least ...

ULTRASONIC MAMMALIAN TEETH AND GUM TREATMENT SYSTEM AND METHOD

Embodiments of teeth and gum treatment employing ultrasonic transducers are described generally herein. Other embodiments may be described and claimed. 1. A system for treating mammalian teeth and gum pain , including a base including a controllable vibrational transducer; anda teeth and gum engaging head coupled to the vibrational transducer to receive vibrationsgenerated by the transducer, the head having two substantially continuous planar surface areas separated by a width less than the heights of the planar surface areas, the head made substantially of a pliable medical grade material and sized to be comfortably insertable into a mammalian month having teeth and gum to be treated.2. The system for treating mammalian teeth and gum pain of claim 1 , wherein the teeth and gum engaging head is coupled to the vibrational transducer via a substantially rigid extension directly coupled to the vibrational transducer.3. The system for treating mammalian teeth and gum pain of claim 1 , wherein the teeth and gum engaging head is removably coupled to the vibrational transducer via a substantially rigid extension directly coupled to the vibrational transducer and indirectly couplable to the teeth and gum engaging head.4. The system for treating mammalian teeth and gum pain of claim 1 , wherein the base includes a proximal end and distal end and a longitudinal axis therebetween claim 1 , and the teeth and gum engaging head includes an extension extending from the two substantially continuous planar surface areas claim 1 , the extension configured to be removably couplable to the base distal end.5. The system for treating mammalian teeth and gum pain of claim 4 , further including a substantially rigid extension directly coupled to the vibrational transducer and indirectly couplable to the teeth and gum engaging head extension.6. The system for treating mammalian teeth and gum pain of claim 1 , further including a control module electrically coupled to the transducer and a ...

Assembly for imaging and/or treating brain tissue

The present invention relates to an assembly for imaging and/or treating brain tissue, having at least one acoustic window (10) which comprises a plate (1) that is transparent to ultrasonic waves, and at least one positioning marker (2) which facilitates positioning of a probe for generating ultrasonic waves so as to be aligned with said acoustic window (10).

SYSTEMS AND METHODS FOR SELECTIVE, TARGETED OPENING OF THE BLOOD-BRAIN BARRIER

Systems and methods for applying ultrasound sonication to temporarily disrupt a patient's blood-brain barrier (BBB) include storing threshold values of an acoustic response level, an acoustic response dose and a tissue response dose associated with a target BBB region and its surrounding regions based on anatomical characteristics thereof; causing the ultrasound transducer to transmit one or more pulses/waves; measuring the acoustic response level, the acoustic response dose, and/or the tissue response dose associated with the target BBB region and/or its surrounding regions; comparing the measurement with a corresponding stored threshold value; and operating the transducer based at least in part on the comparison. 1. A system for temporarily disrupting a patient's blood-brain barrier (BBB) , the system comprising:an ultrasound transducer; anda controller configured to:(a) store at least one of threshold values of an acoustic response level, a cumulative acoustic response dose, and a tissue response dose associated with at least one target BBB region and its surrounding regions;(b) cause the transducer to transmit at least one ultrasound pulse;(c) acquire at least one of the acoustic response level, the acoustic response dose, or the tissue response dose associated with at least one of the target BBB region or its surrounding regions;(d) compare the measurement with a corresponding stored threshold value; and(e) operate the transducer based at least in part on the comparison.2. The system of claim 1 , wherein the controller is further configured to:cause at least one of a detection device or the transducer to measure acoustic signals from the target BBB region and/or its surrounding regions; anddetermine the acoustic response level, the acoustic response dose, and/or the tissue response dose based at least in part on the measured acoustic signals.3. The system of claim 2 , further comprising a filter for filtering the measured acoustic signals from the target BBB ...

Control method for the treatment of brain tissue

The present invention relates to a method for controlling a probe for the treatment of brain tissue using an assembly comprising the probe and an acoustic window (1), the probe (2) including a plurality of transducers (21) for generating ultrasound waves, the method comprising: —a phase of detection: •of the probe transducers situated above the cranium (4) of the patient, and •of the probe transducers situated above the acoustic window (1), so as to permit: •deactivation of the transducers situated above the cranium (4) of the patient, •activation of the transducers situated above the acoustic window (1).

System and method for generating heat at target area of patient's body

A method and system is provided for generating and distributing heat at a target area of a patient's body for treating lesions, tumours, cancers, body pain and nerve pain. The generated heat and the tissue temperature are monitored in real time. The system comprises a radio frequency (RF) antenna for receiving the RF waves generated from the RF generator. A RF absorber comprising several closed loop circuits and a miniaturized thermometer are implanted inside the body close to the target tissue. A controller/optimizer regulates a frequency and a transmission timing of the RF waves based on the measured target tissue temperature. The thermometer, the RF absorber and the wireless transmitter are placed in a screw. The RF absorber is made of metal with RF absorption rate higher than that of biological tissues. A ultrasound energy is also used to treat the target area.

System and method for generating heat at target area of patient's body

The embodiments herein provide a method and system for generating heat at a target area of a patient's body for treatment of lesions, tumors, cancer cells, body pain and nerve pain. The heat generated inside a target tissue is distributed throughout the target area. The system and method provides a real time monitoring of the generated heat and the temperature of the tissue. The system comprises a radio frequency (RF) antenna/transducer for receiving the generated RF waves from the RF generator. A controller/optimizer is provided for controlling a frequency of the RF waves and a transmission timing of the RF waves. A RF absorber/distributor comprising a plurality of closed loop circuits is provided. A miniaturized thermometer is arranged inside the RF absorber is arranged close to irradiation area for measuring the temperature which is transmitted to the controller. Several needles/probes are implanted at the target location of patient's body.

TREATMENT OF SUBARACHNOID HEMATOMA USING SONOTHROMBOLYSIS AND ASSOCIATED DEVICES, SYSTEMS AND METHODS

Methods for treating a human patient having a subarachnoid hematoma, such as to prevent cerebral vasospasm or to reduce the severity of cerebral vasospasm in the patient, and associated devices, systems, and methods are disclosed herein. In a particular embodiment, a thrombolytic agent is introduced extravascularly into a subarachnoid region including the hematoma. A headset configured for hands-free delivery of transcranial ultrasound energy is connected to the patient and used to deliver ultrasound energy to the subarachnoid region to enhance the thrombolytic effect of the thrombolytic agent. The type and/or dosage of the thrombolytic agent can be selected based on the enhanced thrombolytic effect. For example, the enhanced thrombolytic effect can allow the therapeutically effective use of less aggressive thrombolytic agents and/or lower dosages of thrombolytic agents. In some cases, this can reduce the clinical probability of additional cerebral hemorrhage. 127-. (canceled)28. A system for treating a human patient having basal cisterns and a basal subarachnoid region encompassing the basal cisterns , the system comprising:a headset including ultrasound transducers positioned to direct ultrasound energy evenly throughout the basal subarachnoid region; anda controller operably connected to the headset, wherein the controller is configured to control delivery of ultrasound energy to the basal subarachnoid region via the ultrasound transducers to enhance a thrombolytic effect of extravascular thrombolytic agent at the basal subarachnoid region.29. The system of wherein the controller is configured to control an intensity at which ultrasound energy is delivered to the basal subarachnoid region via the ultrasound transducers to enhance the thrombolytic effect.30. The system of wherein the controller is configured to control a frequency at which ultrasound energy is delivered to the basal subarachnoid region via the ultrasound transducers to enhance the thrombolytic ...

Systems and Methods for Mechanogenetic Functional Ultrasound Imaging

The present disclosure provides a system for functional ultrasound imaging, where the system comprises: a) an apparatus for delivering a nucleic acid encoding a mechanosensitive ion channel to a target neural cell population in a region of a brain; and b) a functional ultrasound imaging device. The present disclosure provides a method for functional ultrasound imaging.

X-OPTOGENETICS / U-OPTOGENETICS

Methods and systems for performing optogenetics using X-rays or ultrasound waves are provided. Visible-light-emitting nanophosphors can be provided to a sample, and X-ray stimulation can be used to stimulate the nanophosphors to emit visible light. Alternatively, ultrasonic waves can be provided to the sample to cause sonoluminescence, also resulting in emission of visible light, and this can be aided by the use of a chemiluminescent agent present in the sample. The emitted light can trigger changes in proteins that modulate membrane potentials in neuronal cells. 1. A method of performing optogenetics , comprising:providing light-emitting particles to a sample; andproviding X-rays to the sample such that the X-rays cause the light-emitting particles to emit light, thereby changing the membrane potential of a neuron within the sample.2. The method according to claim 1 , wherein the light-emitting particles are visible-light-emitting nanophosphors claim 1 , such that the nanophosphors emit light in the visible spectrum upon stimulation by the X-rays.3. The method according to claim 1 , wherein providing X-rays to the sample comprises providing X-rays with a carbon nanotube X-ray source.4. The method according to claim 3 , wherein the carbon nanotube X-ray source includes a carbon nanotube cathode emitting electrons that are focused onto an anode through at least one of a gate electrode and focusing electrode.5. The method according to claim 1 , wherein the sample is an animal brain.6. The method according to claim 1 , wherein providing X-rays to the sample comprises focusing the X-rays with a focusing element after they are provided by an X-ray source and before they reach the sample claim 1 , wherein the focusing element is a poly-capillary lens claim 1 , a Fresnel zone plate claim 1 , or a grating.7. The method according to claim 1 , further comprising providing one or more type of rhodopsins to the sample before providing the X-rays claim 1 , wherein the rhodopsins ...

Methods For Modifying Electrical Currents In Neuronal Circuits

The various embodiments described herein include methods, devices, and systems for providing ultrasound treatment to a patient. In one aspect, a method for adjusting a magnetic resonance guided focused ultrasound (MRgFUS) treatment plan with a magnetic resonance imaging (MRI) system and an ultrasound system includes: (1) identifying a location in a subject that is to receive treatment; (2) applying pulses of focused ultrasound to the identified location with the ultrasound system in order to modulate a level of naturally occurring hormones; (3) concurrently with applying the pulses of focused ultrasound, acquiring with the MRI system functional image data from the subject; (4) obtaining a series of functional images of the subject using the functional image data, the functional images indicative of the modified neuronal activity; and (5) adjusting one or more parameters of the MRgFUS treatment plan using the reconstructed series of functional images. 1. A method for adjusting a magnetic resonance guided focused ultrasound (MRgFUS) treatment plan with a magnetic resonance imaging (MRI) system and an ultrasound system , comprising:identifying a location in a subject that is to receive treatment;applying pulses of focused ultrasound to the identified location with the ultrasound system in order to modulate a level of naturally occurring hormones;concurrently with applying the pulses of focused ultrasound, acquiring with the MRI system functional image data from the subject;obtaining a series of functional images of the subject using the functional image data, the functional images indicative of the modified neuronal activity; andadjusting one or more parameters of the MRgFUS treatment plan using the reconstructed series of functional images.2. The method of claim 1 , wherein identifying the location in the subject that is to receive treatment includes:acquiring, with the MRI system, image data from the subject;reconstructing an image of the subject from the acquired ...

System and method for denervation

An apparatus for vascular denervation, comprising a catheter configured for delivery into a vessel of a patient. A balloon is mounted on a distal tip of the catheter, the balloon being configured to be inflatable and further configured so that, upon inflation, the balloon adopts a shape that includes a first edge and a second edge that wind around each other in a double helix, the first edge and the second edge being separated from each other by a first crease and a second crease that also wind around each other in a double helix. A first electrode is attached to the balloon and is located to extend along the first edge.

STEREOTACTIC FRAME

A stereotactic frame includes a vertical column that extends up from a base. A first laterally extending support arm extends from a first side of the column and a second laterally extending support arm extends from a second side of the column. One of the first or second support arms may include a transducer assembly. The transducer assembly may move a focal point of the transducer in different lateral and longitudinal horizontal positions and different vertical positions. The transducer assembly also may move the focal point of the transducer beam into different pivoting angled positions. The stereotactic frame applies repeatable ultrasonic energy to targets inside a patient without using invasive attachment procedures and without having to repeatedly use expensive magnetic resonance imaging (MRI) machines. 1. A stereotactic frame , comprising:a base for holding a head of a patient;a column extending up from the base for locating next to a top of the head;a first laterally extending support arm extending from a first side of the column for locating next to a first side of the head; anda second laterally extending support arm extending from a second side of the column for locating next to a second side of the head.2. The stereotactic frame of claim 1 , further comprising a transducer assembly attached to the second support arm to retain a transducer and direct ultrasonic energy from the transducer into the head of the patient.3. The stereotactic frame of claim 1 , wherein the transducer assembly includes an opening with rounded inside surfaces to hold the transducer at different pivoting angles.4. The stereotactic frame of claim 2 , wherein the transducer assembly includes:an adjustment member slidingly attached to the second support arm to move the transducer in a horizontal longitudinal direction; anda transducer cradle slidingly attached to the adjustment member to move the transducer in a vertical direction.5. The stereotactic frame of claim 4 , wherein the ...

SYSTEMS AND METHODS FOR OPTIMIZING TRANSSKULL ACOUSTIC TREATMENT

Skull inhomogeneity may be quantified in accordance with the skull density measured in skull images acquired using a conventional imager; the quantified inhomogeneity may then be used to determine whether the patient is suitable for ultrasound treatment and/or determine parameters associated with the ultrasound transducer for optimizing transskull ultrasound treatment. 1. A method of predicting a likelihood of effective transskull ultrasound treatment for individual patients , the method comprising:obtaining a plurality of images of a patient's skull;computationally determining a global parameter representing structural characteristics of the skull on a plurality of beam paths, each beam path extending from an ultrasound transducer element to the skull; andbased at least in part on the global parameter, determining the likelihood of successful ultrasound treatment of the patient.2. The method of claim 1 , further comprising computationally determining a plurality of local parameters claim 1 , each local parameter representing local structural skull characteristics on one of the beam paths claim 1 , the global parameter being determined based on at least some of the local parameters.3. The method of claim 2 , further comprising assigning a weighting factor to each of the local parameters based on an incidence angle of the associated beam path through the skull claim 2 , the global parameter being determined based on a weighted average of the at least some of the local parameters.4. The method of claim 3 , wherein a weighting factor of one is assigned to each local parameter corresponding to a beam path having an incidence angle smaller than a critical angle and a weighting factor of zero is assigned to each local parameter corresponding to a beam path having an incidence angle larger than the critical angle.5. The method of claim 3 , wherein the weighting factor is determined based on a logistic function.7. The method of claim 2 , wherein the local parameter ...

Methods for renal neuromodulation

Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney.

DEVICES, SYSTEMS, AND METHODS FOR SPECIALIZING, MONITORING, AND/OR EVALUATING THERAPEUTIC NASAL NEUROMODULATION

Devices, systems, and methods for specializing, monitoring, and/or evaluating therapeutic nasal neuromodulation are disclosed herein. A targeted neuromodulation system configured in accordance with embodiments of the present technology can include, for example, an evaluation/modulation assembly at a distal portion of a shaft and including a plurality of electrodes. The electrodes are configured to emit stimulating energy at frequencies for identifying and locating target neural structures and detect the resultant bioelectric properties of the tissue. The system can also include a console that maps locations of the target neural structures. The evaluation/modulation assembly can then apply therapeutic neuromodulation energy in a highly tailored neuromodulation pattern based on the mapped locations of the target neural structures. Accordingly, the system provides therapeutic neuromodulation to highly specific target structures while avoiding non-target structures to reduce collateral effects. 144.-. (canceled)45. A treatment system comprising:a treatment device comprising an end effector comprising a feedback element and a treatment element; anda console including a controller operably associated with the treatment device, the controller having a computer-readable medium carrying instructions, which when executed by the controller, causes the console to: receive feedback from the feedback element of the end effector, determine locations of target neural structures and vessels at a treatment site based on the received feedback, generate a treatment pattern that distinguishes the locations of the target neural structures from the locations of the vessels at the treatment site, and apply treatment via the treatment element of the end effector to the treatment site according to the treatment pattern such that treatment is provided to the target neural structures and not the vessels.46. The system of claim 45 , wherein the feedback from the feedback element further allows ...

Patient-Specific Functional Cranioplasty with Integrated Ultrasonic Transmitter Arrangement for Neuromodulation and Opening of the Blood Brain Barrier

The invention relates to an ultrasonic transmitter arrangement () with a plurality of ultrasonic transmitters () arranged on the arrangement whose emittable ultrasonic waves are focused toward a common focus (). The arrangement () is embodied as a cranial bone implant () that can be implanted in the cranial bones () of a person as a replacement for one or more parts of the cranial bone (), with the common focus () of the entire arrangement being arranged in a defined region of the brain () in the implanted state. 123. a plurality of ultrasonic transmitters () arranged in a distributed manner on the arrangement whose emittable ultrasonic waves are or can be focused toward a common focus ();{'b': 1', '4', '5, "wherein the arrangement () is embodied as a cranial bone implant () that can be implanted into a person's cranial bone () as a replacement for a portion thereof; and"}{'b': 1', '6', '3, 'wherein the common focus () of the arrangement lying in a defined region () of the brain in the implanted state, or with it being possible for the common focus () to be guided there in the implanted state;'}21424. The ultrasonic transmitter arrangement () as set forth in claim 1 , wherein the cranial bone implant () is embodied as a calotte and claim 1 , in the implanted state claim 1 , the ultrasound-emitting regions of the ultrasonic transmitters () are arranged on the surface of the calotte () facing toward the brain.3145. The ultrasonic transmitter arrangement () as set forth in claim 2 , wherein the calotte () is modeled after the removed portion of the cranial bone ().41422. The ultrasonic transmitter arrangement () as set forth in claim 2 , wherein the calotte () is a spherical shell segment on which the ultrasonic transmitters () are arranged so as to be distributed claim 2 , and the common natural focus of the ultrasonic transmitters () is the centerpoint of the spherical shell segment.514455aa. The ultrasonic transmitter arrangement () as set forth in claim 4 , wherein ...

Hand-held Battery-Operated Therapeutic Ultrasonic Device

The present invention is a portable hand-held battery-operated therapeutic ultrasonic device that is specifically designed for clinical applications in muscle and joint pain management. The present invention generates stepwise high resolution, high frequency microprocessor-based signal to drive piezo-crystals for applying on the skin of the user. It makes use of a novel electronic driving technology that enables it to generate therapeutically combinations of acoustic intensities from 0 to 2 W/cmand with 80-85% efficiency. It is a lightweight device and can be programmed wirelessly by a physician/professional to be used at home by a patient. 1) A portable and handheld ultrasonic device for therapeutic purposes , comprising:a) a piezo-crystal to generate an ultrasound vibration;b) a stepwise signal driver to drive said piezo-crystal, wherein said stepwise signal driver increases the efficiency of said device by reducing the power loss;c) a processor to control said stepwise signal driver, wherein said processor determines an operating resonance frequency of said piezo-crystal during an operation and under a loading condition to control said stepwise signal driver;d) wherein said operating resonance frequency of said piezo-crystal is determined by maximizing a current passing through said piezo-crystal and by monitoring the change in shape and pattern of a voltage drop across a resistor in series with a bridge circuit, wherein an input frequency is adjusted at a predefined increment and the change in voltage pattern is measured until a maximum current is found;e) a variable voltage source;f) a power source, and 'whereby said stepwise signal driver provides enough power to operate said ultrasonic device with a battery for a true handheld and portable operation.', 'g) a user interface unit,'}2) The portable and handheld ultrasonic device of claim 1 , wherein said stepwise driver generates voltage pulses comprising of an amplitude claim 1 , a pulse duration (a) claim 1 , ...

ULTRASOUND GUIDED OPENING OF BLOOD-BRAIN BARRIER

A system for delivering drugs or other molecules to the brain comprises an ultrasound imaging transducer configured to image structures such as the circle of Willis within a patient's head by way of a low attenuation acoustic window. The system includes a processor configured to register the ultrasound images to previously obtained images which also include the structures. The system includes ultrasound transducer elements operable to deliver ultrasound energy to a target region to cause the blood brain barrier to open. The system may include a drug delivery system that may be operated to deliver a drug to the patient in coordination with opening the blood brain barrier, Coordinates of the target region relative to the ultrasound imaging transducer are determined using registration information. 1. A system operable to deliver ultrasound energy to a patient's brain , the system comprising:an imaging ultrasound transducer;a treatment ultrasound transducer;an ultrasound machine connected to operate the imaging ultrasound transducer to generate one or more ultrasound images;a data store;a data processor configured to:process one of the ultrasound images with a corresponding previously obtained image in the data store to register the previously-obtained image to the ultrasound image to yield a transformation relating coordinates in a frame of reference of the previously obtained image to coordinates in a frame of reference of the ultrasound image;using the transformation, determine coordinates of at least one target region in the frame of reference of the ultrasound image; andbased on the coordinates of the at least one target region, determine a target location for the treatment ultrasound transducer to deliver ultrasound energy to the at least one target region.2. (canceled)3. A system according to wherein the treatment transducer has a frequency of operation lower than a frequency of operation of the imaging transducer.46.-. (canceled)7. A system according to wherein ...

IMAGE-GUIDED PULSED FOCUSED ULTRASOUND

A method for treating a nerve within a treatment region includes identifying the treatment region and positioning a device on a surface of skin for emitting ultrasound energy, wherein the device comprises a transducer array. The method further includes focusing the transducer array within the positioned device such that the ultrasound energy is focused on the treatment region, and verifying the positioned device is directing ultrasound energy on the treatment region. The method also includes delivering ultrasound energy to the treatment region based on a predetermined time, and removing the positioned device when the predetermined time has been reached. 1. A method for treating a nerve within a treatment region , comprising:identifying the treatment region;positioning a device on a surface of skin for emitting ultrasound energy, wherein the device comprises a transducer array;focusing the transducer array within the positioned device such that the ultrasound energy is focused on the treatment region;verifying the positioned device is directing ultrasound energy on the treatment region;delivering ultrasound energy to the treatment region based on a predetermined time; andremoving the positioned device when the predetermined time has been reached.2. The method of claim 1 , wherein the treatment region is located at a depth below a skin surface associated with a patient.3. The method of claim 1 , wherein the treatment region is a dorsal root ganglion located at a depth below a skin surface associated with a patient.4. The method of claim 1 , wherein the ultrasound energy is low intensity focused (liFUS) ultrasound energy.5. The method of claim 1 , wherein the device comprises an imaging transducer claim 1 , and the position of the device is verified via the imaging transducer.6. The method of claim 1 , wherein the device comprises a water circulation system for controlling a temperature associated with the transducer array.7. The method of claim 6 , wherein the water ...

TREATMENTS FOR DIABETIC AND PERIPHERAL NEUROPATHY

A method of treating a patient with diabetic and peripheral neuropathy symptoms has the steps of establishing the severity of neuropathy symptoms and treating the patient with a combination of acoustic shock waves and light therapy. 1. A method of treating a patient with diabetic neuropathy symptoms comprises the steps of:establishing the severity of the neuropathy symptoms;for those patients with symptoms below a threshold level of severity, treating an extremity of those patients with acoustic shock waves followed by near infrared light therapy; andfor patients at or exceeding the threshold level of severity, treating an extremity of those patients with one or more acoustic shock wave treatments over several weeks, monitoring for a reduction in the severity of neuropathy symptoms to below the threshold level of severity and thereafter following an acoustic shock wave treatment, treating the extremity with a near infrared light therapy.2. The method of wherein the step of treating the patient with acoustic shock waves includes the steps of activating an acoustic shock wave generator or source to emit acoustic shock waves through an extremity of the patient; stimulating the sensory nerves of the extremity to rehabilitate and restore function thereby reducing the severity of the diabetic neuropathy symptoms wherein the extremity is positioned in a path of the emitted shock waves.3. The method of wherein the shock wave generator or source is one of ballistic claim 2 , radial claim 2 , piezoelectric claim 2 , or electrohydraulic.4. The method of wherein the emitted shock waves are radial claim 3 , focused claim 3 , non-focused claim 3 , planar claim 3 , nearly planar claim 3 , convergent or divergent.5. The method of wherein the acoustic shock waves have a pressure pulse power density in the range of 0.1 to 1.0 mP.6. The method of further comprises the step of measuring the patient's blood glucose level as part of the step of establishing the severity of the neuropathy ...

Systems and methods for stimulating cellular function in tissue

The invention generally relates to systems and methods for stimulating cellular function in biological tissue. In certain embodiments, the invention provides a method for stimulating cellular function within tissue that involves providing a first type of energy to a region of tissue, in which the first type is provided in an amount that inhibits cellular function within the region of tissue, and providing a second type of energy to the region of tissue, in which the second type is provided in an amount that facilitates cellular function within the region of tissue, wherein the combined effect stimulates cellular function within the tissue.

Methods and Apparatus for Renal Neuromodulation

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

SYSTEM AND METHOD FOR SONOGENETIC THERAPY

One embodiment is directed to a method for acoustically modulating activity of cells comprising a targeted tissue portion of a patient. An implantable probe system may be utilized for delivering acoustical energy to a targeted tissue portion of a patient, comprising a plurality of substrate portions, each substrate portion comprising at least one acoustical emitter; a probe body portion having proximal and distal ends and being movably coupled to the plurality of substrates and configured to at least partially encapsulate the plurality of substrates; and a distal end portion coupled to the distal end of the probe body portion, the distal end portion comprising at least one guiding feature configured to redirect a path of at least one of the substrate portions as such substrate portion is extended through and past the distal end portion by moving the plurality of substrates relative to the probe body portion. 1. A method for acoustically modulating activity of cells comprising a targeted tissue portion of a patient , comprising:A. providing an implantable probe system for delivering acoustical energy to a targeted tissue portion of a patient, the implantable probe system comprising a plurality of substrate portions, each substrate portion comprising at least one acoustical emitter; a probe body portion having proximal and distal ends and being movably coupled to the plurality of substrates and configured to at least partially encapsulate the plurality of substrates; and a distal end portion coupled to the distal end of the probe body portion, the distal end portion comprising at least one guiding feature configured to redirect a path of at least one of the substrate portions as such substrate portion is extended through and past the distal end portion by moving the plurality of substrates relative to the probe body portion; andB. operating the implantable probe system to modulate activity of the cells comprising the targeted tissue portion by controllably activating ...

Methods and systems for modifying electrical currents in neuronal circuits

The various embodiments described herein include methods, devices, and systems for providing ultrasound treatment to a patient. In one aspect, a method for adjusting a magnetic resonance guided focused ultrasound (MRgFUS) treatment plan with a magnetic resonance imaging (MRI) system and an ultrasound system includes: (1) identifying a location in a subject that is to receive treatment; (2) applying pulses of focused ultrasound to the identified location with the ultrasound system in order to modulate a level of naturally occurring hormones; (3) concurrently with applying the pulses of focused ultrasound, acquiring with the MRI system functional image data from the subject; (4) obtaining a series of functional images of the subject using the functional image data, the functional images indicative of the modified neuronal activity; and (5) adjusting one or more parameters of the MRgFUS treatment plan using the reconstructed series of functional images.

Methods and Apparatus for Renal Neuromodulation

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation.

METHODS FOR THERAPEUTIC RENAL NEUROMODULATION

Methods and apparatus are provided for treating hypertension, e.g., via a pulsed electric field, via a stimulation electric field, via localized drug delivery, via high frequency ultrasound, via thermal techniques, etc. Such neuromodulation may effectuate irreversible electroporation or electrofusion, necrosis and/or inducement of apoptosis, alteration of gene expression, action potential attenuation or blockade, changes in cytokine up-regulation and other conditions in target neural fibers. In some embodiments, neuromodulation is applied to neural fibers that contribute to renal function. In some embodiments, such neuromodulation is performed in a bilateral fashion. Bilateral renal neuromodulation may provide enhanced therapeutic effect in some patients as compared to renal neuromodulation performed unilaterally, i.e., as compared to renal neuromodulation performed on neural tissue innervating a single kidney. 1. A method for treating hypertension , the method comprising:modulating a function of a neural fiber that contributes to renal function of a kidney of a patient,wherein modulating the function of the neural fiber further comprises modulating the function without completely physically severing the neural fiber.2. The method of claim 1 , wherein modulating the function of the neural fiber further comprises modulating the function of the neural fiber via an electric field.3. The method of claim 2 , wherein modulating the function of the neural fiber via an electric field further comprises exposing the neural fiber to a pulsed electric field.4. The method of claim 2 , wherein modulating the function of the neural fiber via an electric field further comprises exposing the neural fiber to a stimulation electric field.5. The method of claim 1 , wherein modulating the function of the neural fiber further comprises delivering a neuromodulatory agent to the neural fiber.6. The method of claim 1 , wherein modulating the function of the neural fiber further comprises at ...

Systems and methods for stimulating cellular function in tissue

The invention generally relates to systems and methods for stimulating cellular function in biological tissue. In certain embodiments, the invention provides a method for stimulating cellular function within tissue that involves providing a first type of energy to a region of tissue, in which the first type is provided in an amount that inhibits cellular function within the region of tissue, and providing a second type of energy to the region of tissue, in which the second type is provided in an amount that facilitates cellular function within the region of tissue, wherein the combined effect stimulates cellular function within the tissue.

SYSTEMS AND TECHNIQUES FOR ULTRASOUND NEUROPROTECTION

The disclosure describes devices, systems, and techniques for reducing neural degeneration within a brain of a patient. In one example, a method includes delivering, via one or more ultrasound transducers, ultrasound energy focused to a targeted region of the brain of the patient according to ultrasound parameters. The ultrasound parameters are selected to generate ultrasound energy that reduces or prevents neural degeneration within at least a portion, such as a selected region, of the brain associated with the targeted region of the brain. The targeted region of the brain may include at least a portion of the selected region of the brain and/or neurons that affect different neurons within the selected region of the brain. 1: A method for reducing or preventing neural degeneration within a brain of a patient , the method comprising:delivering, via one or more ultrasound transducers, ultrasound energy focused to a targeted region of the brain of the patient according to ultrasound parameters, wherein the ultrasound parameters are selected to generate ultrasound energy that reduces or prevents neural degeneration within at least a portion of the brain.2: The method of claim 1 , wherein the portion of the brain comprises a selected region of the brain claim 1 , and wherein the method further comprises selecting one or more ultrasound parameter values for the ultrasound parameters that at least partially define delivery of ultrasound energy focused to the targeted region of the brain of the patient that reduces or prevents neural degeneration within the selection region of the brain.3: The method of claim 2 , further comprising:receiving, by the processor, a first signal from the selected region of the brain;associating, by the processor, the first signal with a resting state of the selected region of the brain;selecting, by a processor, an initial ultrasound parameter set;delivering, by the processor, ultrasound energy to the targeted region of the brain according to ...

Apparatus, method, and computer-readable recording medium for generating tactile sensation through non-invasive brain stimulation using ultrasonic waves

The present invention relates to an apparatus for creating a tactile sensation through non-invasive brain stimulation by using ultrasonic waves. The apparatus includes: an ultrasonic transducer module for inputting the ultrasonic waves to stimulate a specific part of the brain of a specified user non-invasively through at least one ultrasonic transducer unit; a compensating module for acquiring information on a range of tactile perception areas in the brain of the specified user and compensating properties of ultrasonic waves to be inputted to the specified user through the ultrasonic transducer unit by referring to the acquired information thereon; and an ultrasonic waves generating module for generating ultrasonic waves to be inputted to the specified user through the ultrasonic transducer unit by referring to a compensating value decided by the compensating module.

Implants using ultrasonic waves for stimulating tissue

Described herein are implantable devices configured to emit an electrical pulse. An exemplary implantable device includes an ultrasonic transducer configured to receive ultrasonic waves that power the implantable device and encode a trigger signal; a first electrode and a second electrode configured to be in electrical communication with a tissue and emit an electrical pulse to the tissue in response to the trigger signal; and an integrated circuit comprising an energy storage circuit. Also described are systems that include one or more implantable device and an interrogator configured to operate the one or more implantable devices. Further described is a closed loop system that includes a first device configured to detect a signal, an interrogator configured to emit a trigger signal in response to the detected signal, and an implantable device configured to emit an electrical pulse in response to receiving the trigger signal. Further described are computer systems useful for operating one or more implantable devices, as well as methods of electrically stimulating a tissue.

DEVICES AND METHODS FOR OPTIMIZED NEUROMODULATION AND THEIR APPLICATION

Disclosed are methods and systems for optimized deep or superficial deep-brain stimulation using multiple therapeutic modalities impacting one or multiple points in a neural circuit to produce Long-Term Potentiation (LTP) or Long-Term Depression (LTD). Also disclosed are methods for treatment of clinical conditions and obtaining physiological impacts. Also disclosed are: methods and systems for Guided Feedback control of non-invasive deep brain or superficial neuromodulation; patterned neuromodulation, ancillary stimulation, treatment planning, focused shaped or steered ultrasound; methods and systems using intersecting ultrasound beams; non-invasive ultrasound-neuromodulation techniques to control the permeability of the blood-brain barrier; non-invasive neuromodulation of the spinal cord by ultrasound energy; methods and systems for non-invasive neuromodulation using ultrasound for evaluating the feasibility of neuromodulation treatment using non-ultrasound/ultrasound modalities; neuromodulation of the whole head, treatment of multiple conditions, and method and systems for neuromodulation using ultrasound delivered in sessions. 1. A method for neuromodulation by one or more neuromodulation modalities of one or a plurality of neural targets comprising:a. providing one or a plurality of neuromodulation transducers;b. aiming the energy of said ultrasound transducers at one or a plurality of applicable neural targets; andc. neuromodulating the ultrasound transducers with a control unit using guided-feedback neuromodulation wherein a set of neuromodulation parameters/variables is applied in a given time segment, the patient, operator, or agent judges the result, and based on that feedback result an optimization algorithm is applied to determine the neuromodulation parameters/variables to be applied in the next time segment.2. The method of where the optimization algorithm guiding the neuromodulation is not limited to but generally selected from the group consisting of ...

Magnetic Stimulation Device

A device for magnetic stimulation of body regions, including at least one magnetic coil connected to a stimulator which has a power element for generating electrical impulses to be applied to the at least one magnetic coil, so that the generated magnetic field can be induced in the body region, wherein a detection unit is provided for detecting metal elements within the body region. A measuring device is provided for detecting the electrical power received by the magnetic coil and a comparison device is provided for comparing the power with a predetermined limit value, the detection unit is connected to the stimulator, and the comparison unit is designed to automatically switch off the stimulator or reduce the power of the stimulator or of the power element of the stimulator in the event of the predetermined limit value being exceeded. 18.-. (canceled)9. A device for magnetic stimulation of regions of a human or animal body , comprising at least one magnetic coil connected to a stimulator which has a power element for generating electrical impulses to be applied to the at least one magnetic coil , so that the magnetic field generated in the at least one magnetic coil can be induced in the body region , wherein a detection unit is provided for the detection of metal elements within the body region in which the magnetic field is induced , and the detection unit is connected to a display unit and to the stimulator , wherein a measuring device is provided for detecting the electrical power received by the at least one magnetic coil in response to a test signal fed in the magnetic coil by measuring the amount and the phase of the current and the voltage at the magnetic coil , and a comparison device is provided for comparing the received electrical power with a predetermined limit value set during a preceding calibration , and the comparison unit is designed to automatically switch off the stimulator or reduce the power of the stimulator or of the power element of the ...

METHODS FOR RENAL NEUROMODULATION

Methods and apparatus are provided for renal neuromodulation using a pulsed electric field to effectuate electroporation or electrofusion. It is expected that renal neuromodulation (e.g., denervation) may, among other things, reduce expansion of an acute myocardial infarction, reduce or prevent the onset of morphological changes that are affiliated with congestive heart failure, and/or be efficacious in the treatment of end stage renal disease. Embodiments of the present invention are configured for percutaneous intravascular delivery of pulsed electric fields to achieve such neuromodulation. 123-. (canceled)24. A method for performing renal neuromodulation , the method comprising:applying a stimulation signal to tissue of a human patient;monitoring a physiologic response to the stimulation signal via electrical impedance tomography to determine the presence of renal nerves proximate a renal blood vessel of the patient; andinhibiting neural activity along the renal nerves in a minimally invasive manner,wherein inhibiting neural activity along the renal nerves comprises delivering an energy field to the renal nerves via an intravascularly positioned catheter.25. The method of claim 24 , further comprising identifying one or more optimal locations for delivering the energy field based on the monitored physiologic response.26. The method of wherein applying a stimulation signal and monitoring a physiologic response comprises:applying a first stimulation signal and monitoring a first physiologic response prior to delivering the energy field; andapplying a second stimulation signal and monitoring a second physiologic response after delivering the energy field.27. The method of claim 26 , further comprising comparing the first physiologic response and the second physiologic response to determine an extent of renal neuromodulation.28. The method of wherein the stimulation signal is a first stimulation signal claim 24 , and wherein the method further comprises applying a ...

A non-invasive method for selective neural stimulation by ultrasound

In an aspect of the present disclosure there is provided a method for reversibly stimulating neuronal cells, said method comprising activating mechanosensitive ion channels of neuronal cells expressing said channels by exposing said cells to an ultrasound stimulus.

Disruption of tau entanglements and amyloid plaques in the human brain by low frequency high power focused ultrasound

A method is provided to disrupt tau entanglements and amyloid plaques in a person's brain. An ultrasound profile generated by an ultrasound device is applied to the person's brain. The generated ultrasound profile is characterized by a frequency between 20-100 kHz, a pulse power greater than 10 W/cm −2 , a pulse length greater than 1 microsecond, and an interval between pulses greater than 1 millisecond. The method is performed without intravenous injection of microbubbles to the person or use of preformed microbubbles.

ENERGY DELIVERY TO INTRAPARENCHYMAL REGIONS OF THE KIDNEY

A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall. 119-. (canceled)20. A method to treat hypertension comprising:advancing a catheter into a kidney of a patient; anddelivering energy from the catheter to an intra-parenchymal region inside the kidney;wherein the energy is delivered to create a flow-restricting lesion inside the kidney.21. The method of claim 20 , wherein the energy is radiofrequency energy.22. The method of claim 20 , wherein the energy is x-ray.23. The method of claim 20 , wherein the energy is microwave energy.24. The method of claim 20 , wherein the energy is ultrasound energy.25. The method of claim 20 , where the catheter is placed in a hilum of the kidney.26. The method of claim 20 , wherein the catheter is configured to generate vibratory energy.27. The method of claim 20 , wherein the flow-restricting lesion is created at a hilum of the kidney to activate mechanoreceptors inside the kidney to send signals to a brain of the patient.28. The method of claim 20 , wherein the flow-restricting lesion is created inside the kidney to affect a hormone generating region inside the kidney.29. The method of claim 20 , wherein the flow-restricting lesion is created inside or on a vein inside the kidney to create a high intra-parenchymal pressure.30. The method of claim 20 , wherein the act of advancing the catheter into the kidney of the patient comprises advancing the catheter into the intra-parenchymal region of the kidney.31. A method to treat hypertension comprising:advancing a catheter into a kidney of a patient; anddelivering energy ...

Implants using ultrasonic backscatter for sensing physiological conditions

Described herein is an implantable device having a sensor configured to detect an amount of an analyte, a pH, a temperature, strain, or a pressure; and an ultrasonic transducer with a length of about 5 mm or less in the longest dimension, configured to receive current modulated based on the analyte amount, the pH, the temperature, or the pressure detected by the sensor, and emit an ultrasonic backscatter based on the received current. The implantable device can be implanted in a subject, such as an animal or a plant. Also described herein are systems including one or more implantable devices and an interrogator comprising one or more ultrasonic transducers configured to transmit ultrasonic waves to the one or more implantable devices or receive ultrasonic backscatter from the one or more implantable devices. Also described are methods of detecting an amount of an analyte, a pH, a temperature, a strain, or a pressure.

SYSTEMS AND METHODS FOR SYNCHRONIZING THE STIMULATION OF CELLULAR FUNCTION IN TISSUE

The present invention generally relates to systems and methods for stimulating tissue using synchronized energy from multiple sources. In certain embodiments, the invention provides a system for stimulating tissue that includes a first energy source, a second energy source, and a synchronizing element that synchronizes the two energies such that the combined effect stimulates the tissue. 1. A system for stimulating tissue , the system comprising:a first energy source;a second energy source; anda synchronization element that synchronizes the first and second energy sources, wherein the combined effect stimulates the tissue.2. The system according to claim 1 , wherein the first energy source is an electric source that produces an electric field.3. The system according to claim 2 , wherein the second energy source is a source that produces a mechanical field.4. The system according to claim 3 , wherein the second energy source is an ultrasound device.5. The system according to claim 2 , wherein the electric field is pulsed.6. The system according to claim 2 , wherein the electric field is time varying.7. The system according to claim 2 , wherein the electric field is pulsed a plurality of time claim 2 , and each pulse may be for a different length of time.8. The system according to claim 2 , wherein the electric field is time invariant.9. The system according to claim 3 , wherein the mechanical field is pulsed.10. The system according to claim 3 , wherein the mechanical field is time varying.11. The system according to claim 3 , wherein the mechanical field is pulsed a plurality of time claim 3 , and each pulse may be for a different length of time.12. The system according to claim 2 , wherein the electric field is focused.13. The system according to claim 3 , wherein the mechanical field is focused.14. The system according to claim 3 , wherein both the electric field and the mechanical field are focused.15. The system according to claim 1 , wherein the first and ...

Electroceutical device and wrap for using the same

An electroceutical apparatus and self-care method for treating pain by providing Transcutaneous Electrical Nerve Stimulation (TENS) in combination with pulsed Ultrasound or Light Emitting Diode (LED) treatments. In some embodiments, the apparatus includes a pod unit and a controller, and wrap for holding the pod unit on an area of a user's body. In some embodiments, the wrap may include electrodes and the intensity of the TENS treatment may be adjusted by a user via the controller. In some embodiments, the frequency or output of the treatments is fixed and sequentially delivered to the user in a timed manner.

ULTRASOUND DEVICE FOR TREATMENT OF A TUMOR IN A REGION OF INTERVERTEBRAL DISC TISSUE

An ultrasound device and method for the treatment of intervertebral disc tissue for remediation of back pain. An applicator comprises a catheter and/or needle with a distal tip including one or more ultrasound transducer crystals. The crystals produce high-powered ultrasound energy that is transmitted and absorbed in the disc tissue. The resulting temperature elevation of the disc tissue shrinks the collagen fibers in the surrounding tissue, and/or destroying small nerves that may have invaded and innervated the surrounding degenerated tissue, and can provide increased structural integrity and disc support for the fragmented nucleus pulposus to relieve pressure on the spinal nerves. 1. A minimally invasive applicator device for treatment of a tumor in a region of vertebral tissue , comprising:an insertion device having a proximal end and a distal end for insertion into the tumor tissue, the insertion device being structurally robust for direct insertion into a targeted area of intervertebral disc tissue without damage or misalignment;an ultrasound transducer device coupled to the distal end of the applicator wherein the ultrasound transducer device includes an array of a plurality of transducer crystals which are all aligned along a line defined by an axis enclosed by each of the plurality of transducer crystals disposed sequentially and longitudinally adjacent each other along the axis to form a customized flexible array along the applicator device, thereby enabling ultrasound radiative output treatment outward from the axis of the transducer crystals of an extended region of specific size and shape of the intervertebral disc tissue; andan external RF power generator electrically connected to the ultrasound transducer device, the generator providing power to the ultrasound transducer device.2. The applicator device of claim 1 , wherein the insertion device comprises a catheter or needle.3. The device of claim 2 , wherein in the ultrasound transducer device includes ...

Systems and methods for optimizing transskull acoustic treatment

Skull inhomogeneity may be quantified in accordance with the skull density measured in skull images acquired using a conventional imager; the quantified inhomogeneity may then be used to determine whether the patient is suitable for ultrasound treatment and/or determine parameters associated with the ultrasound transducer for optimizing transskull ultrasound treatment.

Neuromodulation techniques for perturbation of physiological systems

Embodiments of the present disclosure relate to techniques for inducing physiological perturbations in a subject via neuromodulation, e.g., peripheral neuromodulation of a region of interest of an organ. The nature and degree of the perturbations may be related to the subject's clinical condition. Accordingly, an assessment of one or more characteristics of the perturbations may be used to determine a clinical condition of the subject.

Methods and devices for modulating cellular activity using ultrasound

The present invention comprises methods and devices for modulating the activity or activities of living cells, such as cells found in or derived from humans, animals, plants, insects, microorganisms and other organisms. Methods of the present invention comprise use of the application of ultrasound, such as low intensity, low frequency ultrasound, to living cells to affect the cells and modulate the cells' activities. Devices of the present invention comprise one or more components for generating ultrasound waves, such as ultrasonic emitters, transducers or piezoelectric transducers, composite transducers, CMUTs, and which may be provided as single or multiple transducers or in an array configurations. The ultrasound waves may be of any shape, and may be focused or unfocused.

Energy delivery to intraparenchymal regions of the kidney

A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.

Intravascular energy delivery

A method to apply a nerve inhibiting cloud surrounding a blood vessel includes creating a treatment plan, wherein the treatment plan prescribes application of the nerve inhibiting cloud towards at least a majority portion of a circumference of a blood vessel wall, and applying the nerve inhibiting cloud towards the majority portion of the circumference of the blood vessel wall for a time sufficient to inhibit a function of a nerve that surrounds the blood vessel wall.

用于超声波治疗的眼部探针

本发明涉及用于治疗眼部疾病的探针，其包括：环(1)，所述环(1)包括截头锥体(11)，该截头锥体(11)具有适于支撑超声波产生装置(2)的第一端部(111)和用于与患者的眼部(4)接触的第二端部(112)；以及超声波产生装置(2)，所述超声波产生装置(2)包括旨在面向所述第一端部(111)的第一基座(211)，以及与所述第一基座(211)相对的第二基座(212)，应当注意，所述探针进一步包括流量调节器(3)，所述流量调节器(3)用于，在以耦合液填充探针时，消除包含在向所述第一基座(211)流动的所述耦合液中的气泡。

Ultrasound device for facilitating waste clearance of the brain lymphatic system

The present invention relates to an ultrasound device, and more particularly, to an ultrasound device for promoting the waste clearance from the brain lymphatic system. To this end, the ultrasound device comprises: a first frequency generator (210) for generating a predetermined frequency; a first waveform modulator (230) for modulating a waveform of a frequency; a first linear amplifier (250) for amplifying the waveform; a first resonance circuit unit (170a) for matching the impedance of the amplified waveform; and a first transducer (100) connected to the first resonance circuit unit (170a) and irradiating an ultrasound (30) toward the mammalian brain (10). Provided is the ultrasound device for promoting the waste clearance from the brain lymphatic system, characterized in that the ultrasound (30) promotes the waste clearance from the brain lymphatic system (10). The ultrasound passing through the skull of a mammal is irradiated into the deep brain to induce volume flow by dynamic pressure.

Method for stimulating, and apparatuses performing the same

Disclosed are a method for more locally stimulating a desired target area on a specific portion of an object, and a device therefor. According to an embodiment of the present invention, the stimulation device comprise: a first ultrasound generation device outputting a first ultrasonic beam to the specific portion of the object; a second ultrasound generation device outputting a second ultrasonic beam to the specific portion of the object; and a controller controlling the first ultrasound generation device and the second ultrasound generation device so that an intersecting angle between the first ultrasound generation device and the second ultrasound generation device can form a specific angle, while central axes of the first ultrasound generation device and the second ultrasound generation device are arranged on the same plane.

Ultrasound modulation system

Ultrasound-based neuromodulation system

A neuromodulation system including a catheter has a balloon along its distal end. An ultrasound transducer positioned within an interior of the balloon can be selectively activated to emit acoustic energy radially outwardly, targeting nerve tissue and other portions of the subject anatomy. Targeted nerve tissue can be heated by the application of ultrasonic energy to neuromodulate the tissue. The system may be delivered over a guidewire. A catheter enhances fluid delivery to a distal end of the catheter while reducing an overall diameter of the catheter. The catheter comprises a guidewire lumen that is eccentric relative to a center axis of the catheter.

Methods and devices for modulating cellular activity using ultrasound

本发明包括用于调节活细胞(例如在人、动物、植物、昆虫、微生物和其他有机体中发现或衍生的细胞)的一种或多种活动的方法和装置。本发明的方法包括施用超声(例如低强度低频超声)至活细胞以影响细胞和调节细胞活性的应用。本发明的装置包括产生超声波的一种或多种组件，例如超声发射器、换能器、或压电换能器、复合换能器、CMUT、和可设置为单或多换能器或设置在阵列构造中的组件。超声波可以是任何形状的，并且可以是聚焦的或未聚焦的。