Process for the preparation of calcium salt suspensions

The current invention is related to a novel process for the production of aqueous suspensions of micro and nanoparticles of calcium salts smaller than 10 μm particle size, along with a method to enrich nutritional, nutraceutical, and pharmaceutical beverages with calcium salts. In the process, an aqueous suspension of calcium salt is subjected to pressurization with critical, subcritical, or supercritical carbon dioxide to increase the solubility of the calcium salt, which has a particle size greater than 30 μm. The resulting solution is expanded through a nozzle to generate a calcium salt suspension of micro and nanoparticles that is imperceptible to sight and taste.

Sequestration of carbon dioxide into underground structures

An apparatus comprises a separator, a compressor, a mixer and a pump. The separator operates on an input gas mixture comprising carbon dioxide gas and one or more other gases, providing a separated carbon dioxide gas output. A compressor compresses the separated carbon dioxide gas output, providing a second output comprising at least one of gaseous carbon dioxide and liquid carbon dioxide. A mixer mixes the second output with liquid water under pressure to provide a third output comprising: at least one of liquid carbon dioxide and gaseous carbon dioxide; and water with dissolved carbon dioxide. A pump pumps the third output into an underground structure such that components of the third output react with available rock surfaces to form stable carbonates.

Composite particle manufacturing device and composite particle manufacturing method

[Solution] A device for manufacturing composite particles includes at least one first inlet flow path (2) for supplying a first fluid, at least one second inlet flow path (3) for supplying a second fluid, and a mixing flow path (5) for merging the first fluid and the second fluid supplied respectively from the first inlet flow path and the second inlet flow path and allowing the two kinds of fluids to flow down for a predetermined length while mixing the two kinds of fluids. The mixing flow path is a continuous flow path and has a heterogeneous cross-sectional flow path area in a continuity direction thereof.

Modular supercritical fluid materials processing system

A modular system for processing an exfoliated aggregate material or a polymer composite material comprising the exfoliated aggregate, utilizing supercritical fluid processing is described. The modular system may provide exfoliated aggregate particulates, polymer composite materials or master batch polymer composite materials.

Mixing apparatus

The present invention relates to a mixing apparatus. A production unit produces a working fluid that is in a supercritical state or a subcritical state. A storage unit stores a material. A dissolving unit dissolves the material in the working fluid. A mixer mixes the material together in the presence of the working fluid. A material feed valve opens or closes a flow passage through which the material is to pass to be fed from the storage unit into the dissolving unit. A working fluid inflow valve opens or closes a flow passage through which the working fluid is to pass to flow into the dissolving unit from the production unit. A mixer inflow valve opens or closes a flow passage through which the working fluid and the material are to pass to flow into the mixer from the dissolving unit.

Apparatus for proportioning two components to form a mixture

A method and apparatus is provided for combining two components to form a coating material formulation in which one of the components is a "high volume" component comprising a resin including supercritical fluid as a diluent, and the other of the components is a "low volume" component, such as a catalyst. The relative ratio of resin to catalyst is controlled by adjusting the catalyst pressure as a function of the pressure at which the resin is supplied to ,one or more coating dispensers and by adjusting the duty cycle of a catalyst valve within the catalyst flow path.

超臨界状態を用いた分散方法及び分散装置

(57)【要約】 【課題】 超臨界流体を用いて効率よく分散を行う。 【解決手段】 分散質と溶媒の混合物を超臨界容器 （６）に供給する。この超臨界容器（６）に超臨界溶媒 を供給する。この超臨界溶媒を臨界温度、臨界圧力以上 に加熱加圧し、超臨界流体とする。その後上記混合物と 超臨界流体を攪拌混合する。得られた超臨界混合物を爆 砕槽(10)において大気圧に解放する。これにより上記分 散質は溶媒中に効率よく分散する。

Method of combining materials

Apparatus and method for inverting polymer latices

Disclosed herein are inversion systems and methods of diluting w/o latices including about 10 wt% to 80 wt% of a water soluble polymer. Using the inversion systems and methods described herein, dilution of w/o latices is carried out in a single step to form dilute latices having 10,000 ppm or less polymer; the dilute latices form polymer solutions with no further addition of mixing force or water. The solution viscosities of the polymer solutions obtained using the systems and methods of the invention are at least about 80% of solution viscosity expected in the absence of shear.

用于使聚合物胶乳反相的设备和方法

本文中公开稀释包含约10‑80wt％的水溶性聚合物的w/o胶乳的反相系统和方法。使用本文中所描述的所述反相系统和方法，在单个步骤中进行w/o胶乳的稀释以形成具有10,000ppm或更低聚合物的稀释胶乳；所述稀释胶乳在不进一步添加混合力或水的情况下形成聚合物溶液。使用本发明的所述系统和方法获得的所述聚合物溶液的溶液粘度是在不存在剪切力的情况下所预期的溶液粘度的至少约80％。

Apparatus and method for inverting polymer latices

Disclosed herein are inversion systems and methods of diluting w/o lattices including about 10 wt % to 80 wt % of a water soluble polymer. Using the inversion systems and methods described herein, dilution of w/o lattices is carried out in a single step to form dilute lattices having 10,000 ppm or less polymer; the dilute lattices form polymer solutions with no further addition of mixing force or water. The solution viscosities of the polymer solutions obtained using the systems and methods of the invention are at least about 80% of solution viscosity expected in the absence of shear.

초임계 유체와 약액의 혼합장치 및 그것을 사용하여 초임계유체 혼합물을 공급하는 방법

본 발명은 초임계 이산화탄소의 순환장치 및 순환방법에 관한 것이다. 본 발명의 초임계 이산화탄소 순환장치는, 초임계 상태로 사용된 이산화탄소로부터 이물질을 제거한 후 열과 압력을 가하는 초임계형성수단을 경유하도록 하여 이산화탄소가 다시 초임계 상태로 만들어져 공급되도록 하는 것으로서, 초임계 상태로 사용된 이산화탄소를 가열하여 완전한 가스 상태의 이산화탄소가 되도록 하는 가열수단; 상기 가열수단을 경유한 이산화탄소 가스가 경유하게 되고, 경유하는 이산화탄소로부터 이물질을 제거하는 필터; 상기 필터를 경유한 이산화탄소 가스가 액체 상태가 되도록 냉각하는 냉각수단; 상기 냉각수단을 경유한 가스가 유입되어 저장되는 댐퍼; 및 상기 댐퍼에 저장된 액체 상태의 이산화탄소를 초임계형성수단으로 공급하는 고압펌프;를 포함하여 구성된다. 본 발명의 초임계 이산화탄소 순환장치 및 순환방법은, 이산화탄소로부터 이물질을 분리하는 효율이 우수할 뿐만 아니라 순환라인을 통한 이산화탄소의 순환효율이 우수한 결과를 가져오는 특징이 있다.

Method and apparatus for enhanced size reduction of particles

The present invention provides methods and apparatus for producing particles via supercritical fluid processing. In one embodiment, the method includes expanding a supercritical fluid plasticized melt across a pressure drop to form solid composite particles that are simultaneously dispersed, foamed and cooled, and milling the solid particles produced to achieve the desired size distribution. In another embodiment, a pressure vessel containing a supercritical fluid plasticized melt is depressurized to form a cooled solid porous mass, which is then milled to obtain solid composte particles.

Method and apparatus for enhanced size reduction of particles

The present invention provides methods and apparatus for producing particles via supercritical fluid processing. In one embodiment, the method includes expanding a supercritical fluid plasticized melt across a pressure drop to form solid composite particles that are simultaneously dispersed, foamed and cooled, and milling the solid particles produced to achieve the desired size distribution. In another embodiment, a pressure vessel containing a supercritical fluid plasticized melt is depressurized to form a cooled solid porous mass, which is then milled to obtain solid composte particles.

Method and apparatus for enhanced size reduction of particles

The present invention provides methods and apparatus for producing particles via supercritical fluid processing. In one embodiment, the method includes expanding a supercritical fluid plasticized melt across a pressure drop to form solid composite particles that are simultaneously dispersed, foamed and cooled, and milling the solid particles produced to achieve the desired size distribution. In another embodiment, a pressure vessel containing a supercritical fluid plasticized melt is depressurized to form a cooled solid porous mass, which is then milled to obtain solid composite particles.

Dispensing system for coating material including a catalyst

A method and apparatus for combining two components to form a coating material formulation in which one of the components is a "high volume" component comprising a resin including supercritical fluid as a diluent, and the other of the components is a "low volume" component such as a catalyst wherein resin and catalyst are transmitted through separate, but functionally related, flow paths to a mixer within which they are combined to form a coating material formulation which is then discharged by one or more coating dispenser or spray guns onto a substrate.

Method and apparatus for dispensing coating material including a catalyst

METHOD AND APPARATUS FOR DISPENSING COATING MATERIAL INCLUDING A CATALYST Abstract of the Disclosure A method and apparatus for combining two components to form a coating material formulation in which one of the components is a "high volume" component comprising a resin including supercritical fluid as a diluent, and the other of the components is a "low volume" component such as a catalyst wherein resin and catalyst are transmitted through separate, but functionally related, flow paths to a mixer within which they are combined to form a coating material formulation which is then discharged by one or more coating dispenser or spray guns onto a substrate.

Surface cleaning aerosol production system

본 발명은 표면 세정용 에어로졸 생성 시스템을 제공한다. The present invention provides an aerosol generating system for surface cleaning. 본 발명의 에어로졸 생성 시스템은, 기상의 또는 액상의 세정매체를 공급하는 세정매체 공급원과; 제 1냉매를 냉각시키는 제 1냉각장치와, 제 1냉각장치의 제 1냉매에 의해 냉각되는 제 2냉매를 가지며 이 제 2냉매를 다시 냉각시켜 세정매체 공급원으로부터 배출되는 세정매체를 냉각시키는 제 2냉각장치를 구비하는 저온냉각기와; 저온냉각기로부터 배출되는 세정매체의 배출량을 조절하는 세정매체 유량조절기와; 세정매체와 혼합되어 이를 고속으로 운반할 수 있는 캐리어를 공급하는 캐리어 공급원과; 캐리어 공급원으로부터 배출되는 캐리어의 배출량을 조절하는 캐리어 유량조절기와; 세정매체를 낮은 압력으로 단열 팽창시켜 이를 고화시키고, 고화된 상기 세정매체를 캐리어와 혼합하여 고속, 고압의 에어로졸로 생성하는 벤츄리 노즐을 포함하는 것을 특징으로 한다. 이러한 본 발명은 정량의 세정매체를 최적의 온도로 냉각시키는 저온냉각기와 유량조절기를 구비함으로써, 노즐로 하여금 더욱 미립화된 정량의 고화물을 생성할 수 있게 한다. 특히, 미립화된 고화물을 이용함으로써, 서브마이크론 크기의 미세한 오염물질까지도 제거할 수 있음은 물론 정량의 세정매체를 이용하여 정량의 고화물을 생성함으로써, 세정매체의 소비량을 줄일 수 있는 장점을 갖는다. An aerosol generating system of the present invention comprises: a cleaning medium supply source for supplying a gaseous or liquid cleaning medium; A second cooling device for cooling the first refrigerant, and a second cooling medium cooled by the first refrigerant of the first cooling device, and cooling the second refrigerant again to cool the cleaning medium discharged from the cleaning medium source. A low temperature cooler having a cooling device; A washing medium flow controller for controlling the discharge of the washing medium discharged from the low temperature cooler; A carrier supply source for supplying a carrier which is mixed with the cleaning medium and which can carry it at high speed; A carrier flow regulator for controlling the discharge of the carrier discharged from the carrier source; It is characterized in that it comprises a venturi nozzle for adiabatic expansion of the cleaning medium to a low pressure to solidify it, and mixing the solidified cleaning medium with a carrier to produce a high-speed, high-pressure aerosol. The present invention is equipped with a low temperature cooler and a flow regulator for cooling the quantitative cleaning medium to the optimum temperature, thereby enabling the nozzle to produce ...

METHOD OF PREPARING COATING MATERRIALS

본 발명은 실온에서 고체인 제1유기물질은 제공하는 단계, 실온에서 고체이고 제1유기 물질과 실질적으로 다른 화학조성물인 제2유기물질을 제공하는 단계, 초임계 유체의 원료(16)를 제공하는 단계, 기계적인 교반기(52)를 갖는 제1용기(12)를 제공하는 단계, 제2용기(14)를 제공하는 단계, 제1 및 제2 유기물질과 초임계 유체를 제1용기 안에 인가하고 상기 물질과 초임계 유체를 기계적으로 교반하는 단계 및 제1용기보다 낮은압력으로 유지되는 제2용기내로 제1 및 제2유기물질을 전부 수집하기 위해 제1용기(12)의 내용물을 제2용기(14)로 방출하는 단계로 이루어지는 코팅물질의 신규하고 개선된 제조 방법을 제공한다.

Finely divided solid crystalline powders via precipitation into an anti-solvent

The present invention is a process for producing a finely divided solid which comprises (1) dissolving the solid to be finely divided in a liquid carrier solvent to form an injection solution and (2) adding the injection solution of step (1) to a volume of anti-solvent sufficient to precipitate or crystallize the solid. The solid can be a pharmaceutical, agricultural chemical, commercial chemical, fine chemical, food item, photographic chemical, dye, explosive, paint, polymer or cosmetic.

Process for making submicron particles

The present invention relates to a process for manufacturing a pulverous preparation of a submicron-sized biologically active compound comprising the steps of dissolving a biologically active compound under elevated pressure in a compressed gas, liquid or supercritical fluid containing a surface modifier; and rapidly expanding the compressed solution thereby precipitating the dissolved compound. An alternative process comprises dissolving the biologically active compound in compressed dimethylether, which may optionally contain a surface modifier; and spraying the compressed solution into an antisolvent phase, optionally containing a surface modifier, under vacuum, atmospheric pressure or elevated pressure. An optional third step involves converting the antisolvent phase into a pulverous preparation using conventional powder processing.

Processes to generate submicron particles of water-insoluble compounds

Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizing the aqueous suspension thus formed with a high pressure homogenizer.

Emulsifying/dispersing system using multi-step vacuum module and process for producing emulsion/dispersion

经由密封垫将减压单元多级连接的多级减压模块，直接或经由热交换器连接在乳化·分散装置的出口侧。多级减压模块一方面对于乳化·分散装置供给必要的背压，而另一方面，通过级联该背压的减压单元，一阶段一阶段地进行减压，从而即使在将乳化物开放于大气时，也不发生起泡。由此，可以在乳化物的生成阶段以及作为产品取出的阶段中的任何一个阶段，都可以防止发生起泡。

Emulsification Method of Fuel Oil and Desulfurizer for Sulfur Oxide Reduction

The present invention relates to an emulsification method of fuel oil and a desulfurization agent, comprising the following: (a) a step of supplying the desulfurization agent to the fuel oil and line-mixing to prepare a mixture; (b) a droplet forming step of forming droplets of the mixture of step (a); (c) a magnetization step of magnetizing the result of step (b) by passing the same through a magnetic field; (d) a swirl mixing step of swirling and mixing the result of step (c); and (e) a colliding step of colliding the result of step (d). The emulsification method of fuel oil and a desulfurization agent, according to an embodiment of the present invention, uses fuel oil, which is oil, as a continuous phase, and a water-based desulfurization agent as a disperse phase and emulsifies the desulfurization agent in the fuel oil into water in oil (W/O), so that the desulfurization agent in the fuel oil can be dispersed stably. During combustion, the fuel oil and the desulfurization agent are combusted together to remove sulfur oxides generated in the combustion process, and thus an effect of reducing sulfur oxides finally emitted can be provided.

Emulsification/dispersion system using multistage depressurization module and method for producing emulsified/dispersed liquid

Disclosed is an emulsification/dispersion system, which comprises an emulsification/dispersion apparatus, and a multistage depressurization module connected to the outlet side of the emulsification/dispersion apparatus directly or through a heat exchanger. The multistage depressurization module is provided with a plurality of depressurization cells arranged in a multistage manner through seals, and adapted to apply a given backpressure to the emulsification/dispersion apparatus and to reduce the backpressure in a stepwise manner through the series of depressurization cells so as to prevent the occurrence of bubbling even when an emulsified liquid is released to atmosphere. The present invention can prevent the occurrence of bubbling in both processes of forming an emulsified liquid and taking out the emulsified liquid as a product.

Liquefied carbon dioxide inflow method and underground infeed device

METHOD AND DEVICE FOR DELIVERING A MIXTURE OF FLUIDS AT HIGH PRESSURE AND USING THE METHOD

Fluid mixture high-pressure delivery procedure and apparatus, for use in supercritical fluid chromatography (SFC), uses high-pressure pump after mixing zone

The procedure for high-pressure (100 - 300 bars) delivery of two or more fluids (A, B, C), especially for SFC, in which the fluids are pre-mixed at a lower pressure (about 50 bars), includes delivery of the first fluid (A) into the mixing zone (m) by a high-pressure pump (1) located downstream of the mixing zone. The first fluid, which is a solvent usable in SFC such as carbon dioxide, is pumped from a container (2) in which it is subjected to a pressure higher than that obtaining in containers (3, 4) holding second and third fluids (B, C), the second fluid being a modifier.

Emulsifying/dispersing system using multi-step vacuum module and process for producing emulsion/dispersion

经由密封垫将减压单元多级连接的多级减压模块，直接或经由热交换器连接在乳化·分散装置的出口侧。多级减压模块一方面对于乳化·分散装置供给必要的背压，而另一方面，通过级联该背压的减压单元，一阶段一阶段地进行减压，从而即使在将乳化物开放于大气时，也不发生起泡。由此，可以在乳化物的生成阶段以及作为产品取出的阶段中的任何一个阶段，都可以防止发生起泡。

Dispersing method and dispersing apparatus using supercritical state

利用超临界流体使固体与液体等的微粒均匀分散于溶剂中的分散方法与装置。将固体、液体等的分散介质与溶剂混合，将此混合物提供给超临界容器。向此超临界容器内提供超临界溶剂。将此超临界溶剂加热加压到临界压力之上而成为超临界流体。然后搅拌混合此混合物与超临界流体。使所得超临界混合物于爆碎槽中释放达到大气压。由此得以高效地将所述分散介质分散到溶剂中。

Method for preparing composite fine particles

The present invention provides a method for preparing composite microspheres of a high-molecular material and a core substance. This method includes the steps of: dissolving a high-molecular material and dispersing a core substance in a high pressure fluid containing a supercritical fluid and an entrainer, under a shear stress of 1 Pa or more; and spraying the resultant high pressure fluid containing the high-molecular material and the core substance into a poor solvent to cause rapid expansion. According to the method of the present invention, composite microspheres having a uniform size of several micrometers or less, and more preferably nanometer order (a size of 1 µm or less) can be obtained.

Process for producing fine-dispersing, solid, crystalline powders by precipitation into nonsolving medium

Process for preparing finely dispersed polymer mixtures

Highly disperse mixtures of at least two polymers which are not fully miscible in the melt under conventional conditions are prepared by melting the polymers employed in the presence of supercritical gases or gas mixtures, vigorously mixing the molten polymers until the viscosity of the melt has dropped by at least 10 %, subsequently cooling the polymer melt with further mixing until the viscosity of the melt has again at least reached the original value, and then decompressing the polymer melt. The highly disperse mixtures prepared in this way can be converted into mouldings in a conventional manner.

Processes for the preparation of developer compositions

A process for preparing a liquid developer composition comprising: a) forming a melt mixture comprised of a polymer resin or resins, a colorant, a charge director additive, and a hydrocarbon liquid carrier, to obtain a first suspension of colored polymeric particles with an area average diameter of from about 2 to about 100 microns; b) dispersing said first suspension in a supercritical fluid medium and thereafter continuously feeding the resultant dispersion to a liquid fluidizing means under pressure to obtain a second suspension comprising a supercritical fluid and liquid developer mixture containing colored polymeric particles with an area average diameter of from about 0.1 to about 10 microns; and c) reducing the pressure to evaporate, and optionally recovering, the supercritical fluid medium from said second suspension, wherein there results a liquid developer mixture containing colored polymeric particles with an area average diameter of less than about 3.0 microns and a solids content of about 10 to about 90 weight percent.

Insoluble drug delivery

Particles of water insoluble biologically active compounds, particularly water-insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.

Processes for microemulsion polymerization employing novel microemulsion systems

This invention is directed to a microemulsion system comprising a first phase including a low-polarity fluid material which is a gas at standard temperature and pressure, and which has a cloud-point density. It also includes a second phase including a polar fluid, typically water, a monomer, preferably a monomer soluble in the polar fluid, and a microemulsion promoter for facilitating the formation of micelles including the monomer in the system. In the subject process, micelles including the monomer are formed in the first phase. A polymerization initiator is introduced into the micelles in the microemulsion system. The monomer is then polymerized in the micelles, preferably in the core of the micelle, to produce a polymeric material having a relatively high molecular weight.

Processes to generate particles of water-insoluble compounds of up to 2000 nm in size

Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizing the aqueous suspension thus formed with a high pressure homogenizer.

Method of preparing coating materials

The present invention provides a new and improved method of producing coating materials comprising the steps of providing a first organic material which is solid at room temperature, providing a second organic material which is solid at room temperature and which is substantially different in chemical composition from the first organic material, providing a source of supercritical fluid, providing a first container having a mechanical agitator, providing a second container, introducing the first and second organic materials and the supercritical fluid into the first container and mechanically agitating such materials and the supercritical fluid, and discharging the contents of the first container into the second container so as to collect substantially all of the first and second organic materials in the second vessel, the second container being maintained at a lower pressure than the first container.

Processes to generate suspensions of water-insoluble biologically active compounds containing particles of sizes of up to two microns

Submicron particles of water-insoluble compounds, particularly drugs, are prepared by simultaneously stabilizing microparticulate suspensions of same with surface modifier molecules by rapid expansion into an aqueous medium from a compressed solution of the compound and surface modifiers in a liquefied gas and optionally homogenizing the aqueous suspension thus formed with a high pressure homogenizer.

Method of producing emulsion

【課題】長時間の処理や膨大なエネルギーを要せずに、高効率で乳化物の製造できる新たな方法を提供する。 【解決手段】（１）水の気／液臨界点近傍の温度及び圧力条件下で、乳化対象の水不溶性物質と水とを相溶させる工程、 （２）前記水不溶性物質と水からなる相溶物を界面活性剤の存在下で冷却して、前記水不溶性物質が水に分散した液、または水が前記水不溶性物質に分散した液を得る工程 を含む、乳化物の製造方法。 【選択図】なし

Processes to Generate Submicron Particles of Water-Insoluble Compounds

수-불용성 화합물, 특히 의약의 서브마이크론 입자는, 액화 기체내의 화합물 및 표면 변형제의 압축 용액으로부터 수용성 미디엄내로의 신속 팽창에 의해 표면 변형제 분자로 마이크로입자 현탁액을 동시에 안정화시킴으로써 제조되며, 선택적으로는 형성된 수용성 현탁액을 고압 균질화기로 균질화하여 제조된다. Water-insoluble compounds, in particular pharmaceutical submicron particles, are prepared by simultaneously stabilizing the microparticle suspension with surface modifier molecules by rapid expansion from the compressed solution of the compound and the surface modifier in liquefied gas into the aqueous medium, optionally Is prepared by homogenizing the formed aqueous suspension with a high pressure homogenizer. 초임계성 기체, 마이크로입자, 인지질, 계면활성제 Supercritical Gases, Microparticles, Phospholipids, Surfactants

Apparatus and method for inverting polymer latices

Disclosed herein are inversion systems and methods of diluting w/o latices including about 10 wt% to 80 wt% of a water soluble polymer. Using the inversion systems and methods described herein, dilution of w/o latices is carried out in a single step to form dilute latices having 10,000 ppm or less polymer; the dilute latices form polymer solutions with no further addition of mixing force or water. The solution viscosities of the polymer solutions obtained using the systems and methods of the invention are at least about 80% of solution viscosity expected in the absence of shear.

Mounting apparatus for cryogenic aerosol cleaning

An apparatus for mounting to a tool having a surface to be cleaned for producing aerosol from a substance for cleaning the surface, includes a flange for mounting to the tool having the surface to be cleaned. A nozzle is mounted to the flange for receiving the substance. The nozzle has at least one exit opening which allows passing of the substance therethrough for expanding the substance from a first pressure to a second pressure which is lower than the first pressure for solidifying at least a substantial portion of the substance and producing aerosol for cleaning the surface. Condensation preventing means is provided for preventing condensation from forming on surfaces of the apparatus and the surface to be cleaned, and contamination preventing means is provided for preventing contaminants from re-contaminating the surface subsequent to removal therefrom.

Emulsification / dispersion system using multistage decompression module and method for producing emulsification / dispersion

減圧セルをシールを介して多段に接続した多段減圧モジュールを乳化・分散装置の出口側に直接または熱交換器を介して接続する。多段減圧モジュールは乳化・分散装置に対して必要な背圧を与える一方、この背圧を縦続した減圧セルで一段階ごとに減圧することで、乳化物を大気に開放したときにもバブリングが発生しないようにする。これにより、乳化物の生成段階および製品としての取り出し段階のいずれの段階においてもバブリングの発生を防止することができる。 A multi-stage decompression module in which decompression cells are connected in multiple stages via seals is connected directly or via a heat exchanger to the outlet side of the emulsification / dispersion device. The multistage decompression module gives the necessary back pressure to the emulsification / dispersion device, while bubbling occurs even when the emulsified product is released to the atmosphere by decompressing this back pressure in stages with a cascaded decompression cell. Do not. Thereby, generation | occurrence | production of bubbling can be prevented in any step of the production | generation stage of an emulsion, and the taking-out stage as a product.

Biocompatible cationic detergents and uses therefor

Provided is a method for preparing a true, homogeneous solution of a pharmaceutical substance dissolved in an organic solvent in which the pharmaceutical substance is not normally soluble. Solubilization is obtained by forming a hydrophobic ion pair complex involving the pharmaceutical substance and an amphiphilic material. The resulting organic solution may be further processed to prepare pharmaceutical powders. A biodegradable polymer may be co-dissolved with the pharmaceutical substance and the amphiphilic material and may be incorporated into a pharmaceutical powder. A preferred method for preparing pharmaceutical powders is to subject the organic solution to gas antisolvent precipitation using a supercritical gas antisolvent such as carbon dioxide. Also provided is a method for making hollow particles having a fiber-like shape which would provide enhanced retention time in the stomach if ingested by a human or animal host. Further provided are novel biocompatible cationic surfactants and uses therefor, including the delivery, in vitro and in vivo, of nucleic acids into cells to transform the cells.

Counter Current Mixing Reactor

A mixing reactor for mixing efficiently streams of fluids of differing densities. In a preferred embodiment, one of the fluids is supercritical water, and the other is an aqueous salt solution. Thus, the reactor enables the production of metal oxide nanoparticles as a continuous process, without any risk of the reactor blocking due to the inefficient mixing inherent in existing reactor designs.

Methods and apparatus for fine particle formation

Methods and apparatuses are provided for forming fine particles of a desired substance comprising dissolving said substance in a fluid such as water to form a solution and mixing the solution with a second fluid such as supercritical carbon dioxide which becomes a gas upon rapid pressure release, and with which the first fluid is at least partially immiscible, and releasing the pressure to form an air-borne dispersion or aerosol comprising particles having an average diameter between about 0.1 and about 6.5 μm.

Method and apparatus for enhanced size reduction of particles

The present invention provides methods and apparatus for producing particles via supercritical fluid processing. In one embodiment, the method includes expanding a supercritical fluid plasticized melt across a pressure drop to form solid composite particles that are simultaneously dispersed, foamed and cooled, and milling the solid particles produced to achieve the desired size distribution. In another embodiment, a pressure vessel containing a supercritical fluid plasticized melt is depressurized to form a cooled solid porous mass, which is then milled to obtain solid composte particles.

Chemical reactions in reverse micelle systems

This invention is directed to conducting chemical reactions in reverse micelle or microemulsion systems comprising a substantially discontinuous phase including a polar fluid, typically an aqueous fluid, and a microemulsion promoter, typically a surfactant, for facilitating the formation of reverse micelles in the system. The system further includes a substantially continuous phase including a non-polar or low-polarity fluid material which is a gas under standard temperature and pressure and has a critical density, and which is generally a water-insoluble fluid in a near critical or supercritical state. Thus, the microemulsion system is maintained at a pressure and temperature such that the density of the non-polar or low-polarity fluid exceeds the critical density thereof. The method of carrying out chemical reactions generally comprises forming a first reverse micelle system including an aqueous fluid including reverse micelles in a water-insoluble fluid in the supercritical state. Then, a first reactant is introduced into the first reverse micelle system, and a chemical reaction is carried out with the first reactant to form a reaction product. In general, the first reactant can be incorporated into, and the product formed in, the reverse micelles. A second reactant can also be incorporated in the first reverse micelle system which is capable of reacting with the first reactant to form a product.

Method for producing (sub) micron sized particles by dissolving in compressed gas and surfactant

(57)【要約】 本発明は、（サブ）ミクロンレベルの大きさの生物学的活性化合物の微粉状調製物を製造する方法であって、（１）生物学的活性化合物を、高圧下で、表面改質剤を含有する、圧縮ガス、液体若しくは超臨界流体にか；又は場合により表面改質剤を含有する、圧縮ジメチルエーテルに溶解する工程；（２ａ）工程（１）の圧縮溶液を急速に膨張させ、溶解した化合物をそれによって沈澱させる工程；又は（２ｂ）工程（１）の圧縮溶液を、場合により表面改質剤を含有する溶解阻害相に、減圧下、大気圧下若しくは高圧下で噴霧する工程；及び（３）場合により、工程（２ｂ）の溶解阻害相を、慣用の粉末加工手法を用いて、微粉状調製物へと転換する工程とを含む方法に関する。本発明による方法では、超臨界溶液に溶解した粒子の凝集又はフロッキュレーションの形成が防止され；更に、助溶剤の添加を必要とせず、そのため、工業的規模での懸濁液の安定化を増大させる。

Method for producing emulsion

The disclosed invention is a method for producing an emulsion, comprising the steps of: (1) causing water and a water-insoluble substance that is to be emulsified to become freely miscible under conditions of temperature and pressure in the vicinity of the vapor-liquid critical point of water; and (2) cooling the product comprised of the water-insoluble substance and water solved each other in the presence of a surfactant to obtain a liquid comprised of the water-insoluble substance dispersed in water or a liquid comprised of water dispersed in the water-insoluble substance. The present invention provides a new method for producing emulsions with high efficiency without requiring a long period of processing or a great amount of energy.

Fluid driven stirring device for compressing gas cleaning system

Insoluble drug delivery

Sample preparation apparatus

A sample preparation apparatus, comprising: an ultrasonic vibrating unit which applies ultrasonic vibration to a sample including an analyte held in a measurement sample container; a sample preparation unit which prepares a measurement sample by mixing the sample including the analyte to which the ultrasonic vibration is applied and a predetermined reagent; and a container transporting unit which transports the measurement sample container holding the sample including the analyte from the ultrasonic vibrating unit to the sample preparation unit.

Counter current mixing reactor

A mixing reactor for mixing efficiently streams of fluids of differing densities. In a preferred embodiment, one of the fluids is supercritical water, and the other is an aqueous salt solution. Thus, the reactor enables the production of metal oxide nanoparticles as a continuous process, without any risk of the reactor blocking due to the inefficient mixing inherent in existing reactor designs.

Chemical reactions in reverse micelle systems

This invention is directed to conducting chemical reactions in reverse micelle or microemulsion systems comprising a substantially discontinuous phase including a polar fluid, typically an aqueous fluid, and a microemulsion promoter, typically a surfactant, for facilitating the formation of reverse micelles in the system. The system further includes a substantially continuous phase including a non-polar or low-polarity fluid material which is a gas under standard temperature and pressure and has a critical density, and which is generally a water-insoluble fluid in a near critical or supercritical state. Thus, the microemulsion system is maintained at a pressure and temperature such that the density of the non-polar or low-polarity fluid exceeds the critical density thereof. The method of carrying out chemical reactions generally comprises forming a first reverse micelle system including an aqueous fluid including reverse micelles in a water-insoluble fluid in the supercritical state. Then, a first reactant is introduced into the first reverse micelle system, and a chemical reaction is carried out with the first reactant to form a reaction product. In general, the first reactant can be incorporated into, and the product formed in, the reverse micelles. A second reactant can also be incorporated in the first reverse micelle system which is capable of reacting with the first reactant to form a product.

Sample preparation apparatus

A sample preparation apparatus, comprising: an ultrasonic vibrating unit which applies ultrasonic vibration to a sample including an analyte held in a measurement sample container; a sample preparation unit which prepares a measurement sample by mixing the sample including the analyte to which the ultrasonic vibration is applied and a predetermined reagent; and a container transporting unit which transports the measurement sample container holding the sample including the analyte from the ultrasonic vibrating unit to the sample preparation unit.

Devices and methods for the production of particles

The present invention provides methods and devices for producing particles with an average diameter less than about 15νm using the precipitation with compressed fluid-antisolvent (PCA) process and the carbon-dioxide assisted nebulization with a bubble dryer (CAN-BD) process. In the methods and nozzles of the invention, at least one jet of supercritical or near-supercritical fluid and at least one jet of solution interact to mix the supercritical or near-supercritical fluid and the solution within a chamber. The solution contains at least one solvent and at least one solute. At least one of the jets is a swirling jet. To form particles, the solvent and supercritical or near-supercritical fluid are then injected into a PCA or a CAN-BD process chamber. The degree of mixing depends in part on the power input into the mixing chamber. Power inputs of about 6.5xl09W/m3 enhance the degree of mixing and allow production of nanoscale particles with the PCA process. The nanoscale particles have a size distribution so that polydispersity is less than about 1.75.

Method of underground injection of liquefied carbon dioxide and apparatus therefor

A method of underground injection and apparatus therefor that would realize efficient penetration or diffusion of liquefied carbon dioxide into a deep aquifer. The method of underground injection of liquefied carbon dioxide comprises the stages of pumping up groundwater from a deep aquifer through a pumping well onto the ground to thereby obtain an injection water; applying a pulsating pressure to the injection water; injecting the injection water applied with the pulsating pressure through an injection well to the deep aquifer; injecting liquefied carbon dioxide from a storage tank while maintaining its liquefied state to the depth of the injection well appropriate for maintaining the liquefied state; and in the injection well, carrying out conversion of liquefied carbon dioxide into microdroplets in the injection water and mixing together to thereby produce a biliquid mixed fluid.

Apparatus for mixing of fluids flowing through a conduit

System for forming aerosols and cooling device incorporated therein

The present invention relates to a cooling device ( 30 ) of the reverse Carnot cycle-type using a refrigerant, and an areosol generation system including it. The cooling device ( 30 ) includes a refrigerator ( 310, 320 ) of the reverse Carnot cycle-type, a cleaning medium conduit ( 120 ), a temperature sensor ( 130 ), and a heater ( 140 ). The intermediate portion of the cleaning medium conduit and the evaporator are wound like a coil in the same configuration so as to maximize the contacting area therebetween. The temperature sensor ( 130 ) measures the temperature of the carbon dioxide discharged from the cooling device ( 30 ), and the heater ( 140 ) is arranged to contact the evaporator of the refrigerator and the intermediate portion of the cleaning medium conduit so as to precisely adjust the liquefying rate of the carbon dioxide according to the temperature measured by the temperature sensor. The carbon dioxide is refrigerated at a temperature in the range of −80° C. to −100° C. through the cooling device ( 30 ), transformed into liquid phase.

Method and apparatus for enhanced size reduction of particles

Counter current mixing device for two different fluids

Processes for microemulsion polymerization employing novel microemulsion systems

This invention is directed to conducting chemical reactions in reverse micelle or microemulsion systems comprising a substantially discontinuous phase including a polar fluid, typically an aqueous fluid, and a microemulsion promoter, typically a surfactant, for facilitating the formation of reverse micelles in the system. The system further includes a substantially continuous phase including a non-polar or low-polarity fluid material which is a gas under standard temperature and pressure and has a critical density, and which is generally a water-insoluble fluid in a near critical or supercritical state. Thus, the microemulsion system is maintained at a pressure and temperature such that the density of the non-polar or low-polarity fluid exceeds the critical density thereof. The method of carrying out chemical reactions generally comprises forming a first reverse micelle system including an aqueous fluid including reverse micelles in a water-insoluble fluid in the supercritical state. Then, a first reactant is introduced into the first reverse micelle system, and a chemical reaction is carried out with the first reactant to form a reaction product. In general, the first reactant can be incorporated into, and the product formed in, the reverse micelles. A second reactant can also be incorporated in the first reverse micelle system which is capable of reacting with the first reactant to form a product.

Method of preparing coating materials

The present invention provides a new and improved method of producing coating materials comprising the steps of providing a first organic material which is solid at room temperature, providing a second organic material which is solid at room temperature and which is substantially different in chemical composition from the first organic material, providing a source of supercritical fluid (16), providing a first container (12) having a mechanical agitator (52), providing a second container (14), introducing the first and second organic materials and the supercritical fluid into the first container and mechanically agitating such materials and the supercritical fluid, and discharging the contents of the first container (12) into the second container (14) so as to collect substantially all of the first and second organic materials in the second vessel, the second container being maintained at a lower pressure than the first container.

Continuous process for microspheres production by using expanded fluids

The invention concerns a process for the continuous treatment of an emulsion and/or a micro-emulsion assisted by an “expanded liquid” for the production of micro- and/or nano-particles or micro- and/or nano-spheres containing one or more active ingredients. In particular, a liquid solvent expanded by compressed or supercritical CO 2 is contacted with an O/W emulsion, or alternatively a W/O emulsion or multiple emulsions, formed by an external phase that is itself a liquid expanded by compressed CO 2 . The expanded liquid forms a solution with the dispersed phase of the emulsion and extracts it inducing the formation of the desired particles of the dissolved compounds. The process is carried out in a counter-current packed column wherein the expanded emulsion is fed from the top, while the expanded liquid is fed from the bottom. Thanks to the presence of the expanded liquid, any deposition of the solid particles produced on the packing elements is avoided, thus preventing any column blockage. A suspension of micro-structured particles of the desired product can be collected continuously at the bottom of the column.

Mixing apparatus

In the present invention, a manufacturing part manufactures a working fluid in a supercritical state or a subcritical state. A storage part stores a material. A dissolving part dissolves the material in the working fluid. A mixer mixes the material in the presence of the working fluid. A material charging valve opens and closes a flow channel through which passes the material charged from the storage part to the dissolving part. A working fluid inflow valve opens and closes a flow channel through which passes the working fluid flowing into the dissolving part from the manufacturing part. A mixer inflow valve opens and closes a flow channel through which passes a fluid (the working fluid and the material) flowing into the mixer from the dissolving part.

Mixing method

Supercritical Carbon-Dioxide Processed Biodegradable Polymer Nanocomposites

A biodegradable film and a method of forming a biodegradable film are provided. In one aspect, the biodegradable film includes a reinforced biodegradable polymer including a biodegradable polymer and a reinforcing agent substantially dispersed throughout the biodegradable polymer by rapid depressurization of a supercritical fluid wherein the reinforced biodegradable polymer is formed into the film.

Delivery of insoluble drugs

(57)【要約】 水不溶性の生物学的活性化合物を溶解して溶液とし、次いで適切な表面変性剤の存在下にて、本溶液を圧縮ガス、圧縮液体、または超臨界流体中に噴霧することによって、100nm〜約300nmの平均粒径を有する水不溶性の生物学的活性化合物（特に、水不溶性薬物）の粒子が製造される。

Method for mixing in a hydrocarbon conversion process

A sequential mixer for mixing a heated hydrocarbon stream and a supercritical fluid to produce an intimately mixed stream upstream of a supercritical reactor. The sequential mixer comprising a body having a body length and a body diameter; a hydrocarbon inlet physically connected to the body, having an inlet diameter, the heated hydrocarbon stream is introduced through the hydrocarbon inlet; a mixed stream outlet physically connected to the body and fluidly connected to the supercritical reactor, having an outlet diameter; a traversing axis extending through the center of the body from the hydrocarbon inlet to the mixed stream outlet; and a plurality of fluid ports physically connected to the body, the plurality of fluid ports are arranged in a port alignment arrayed along the traversing axis, each fluid port has a port diameter and a port angle, the supercritical fluid is injected through the plurality of fluid ports.

Dispersion Method and Dispersion Device Using Supercritical State

본 발명은 고체나 액체의 미립자를 초임계 유체를 이용해서 용매 속으로 균일하게 분산하는 방법 및 장치에 관한 것이다. The present invention relates to a method and apparatus for uniformly dispersing solid or liquid fine particles into a solvent using a supercritical fluid. 고체, 액체 등의 분산질은 용매와 혼합되고, 이 혼합물이 초임계 용기에 제공된다. 이 초임계 용기에 초임계 용매를 제공하여 상기 초임계 용매를 임계압력이상으로 가열가압하여 기체 상태를 거쳐 초임계 유체로 만든다. 그 후 상기 혼합물과 초임계 유체를 교반혼합하여 얻어진 초임계 혼합물을 폭쇄조에서 대기압으로 해방함으로써 상기 분산질을 용매속으로 효율적으로 분산할 수 있다. Dispersions such as solids, liquids and the like are mixed with a solvent and the mixture is provided in a supercritical vessel. A supercritical solvent is provided to the supercritical vessel, and the supercritical solvent is heated and pressurized to a critical pressure or higher to form a supercritical fluid through a gaseous state. Thereafter, the supercritical mixture obtained by stirring and mixing the mixture and the supercritical fluid can be efficiently dispersed in the solvent by releasing the supercritical mixture to atmospheric pressure in the blasting tank.

Sequestration of carbon dioxide into underground structures

An apparatus comprises a separator, a compressor, a mixer and a pump. The separator operates on an input gas mixture comprising carbon dioxide gas and one or more other gases, providing a separated carbon dioxide gas output. A compressor compresses the separated carbon dioxide gas output, providing a second output comprising at least one of gaseous carbon dioxide and liquid carbon dioxide. A mixer mixes the second output with liquid water under pressure to provide a third output comprising: at least one of liquid carbon dioxide and gaseous carbon dioxide; and water with dissolved carbon dioxide. A pump pumps the third output into an underground structure such that components of the third output react with available rock surfaces to form stable carbonates.

A method for the manufacture of foamed plaster with hemp

A method for the manufacture of foamed plaster utilizing a mixture of powdered casting plaster, powdered limestone and hemp fibre. The mixture is fed into a Venturi apparatus (40) under the influence of gravity. Compressed air may be supplied to the Venturi apparatus (40) through an inlet pipe (41) causing air and solid particles to be sucked into the Venturi apparatus (40). The elongated tube is provided with an inlet nozzle arranged to receive a mixture of water mixed with detergent agents. Further, the tube (50) is provided with an inlet nozzle (56) arranged to receive compressed air such that the elongated tube (50) delivers the mixture to a mixing and spray head (60) so as to feed the resulting mixture to a moulding means.

Cooling device and aerosol generation system including the same

本発明は、冷媒を利用した逆カルノーシステム方式の冷却装置とこれを含むエアロゾル生成システムに関するものであり、冷却装置は、逆カルノーシステム方式を利用した冷却機、洗浄媒体移送管、温度センサー及びヒーターなどを含み、洗浄媒体移送管の中間領域と冷却機の蒸発器は、相互間の接触面積を最大化するためにコイル状に同一に巻取されており、温度センサーは、冷却装置から排出される二酸化炭素の温度を測定し、ヒーターは、冷却機の蒸発器と洗浄媒体移送管の中間領域を接触するように設置されて温度センサーから測定された温度により二酸化炭素の液化率を微細に調節し、二酸化炭素は、冷却装置を通過して−８０℃乃至−１００℃に冷却されて液状に相変異する。 【選択図】図３

Countercurrent mixing reactor

Polymer matrices prepared by supercritical fluid processing techniques

Polymer matrices for use in orthopedic, pharmaceutical, and similar mixtures are prepared by mixing two or more polymers and a process medium in a reactor to form a supercritical fluid slurry. The process medium preferably is carbon dioxide which is supplied to the reactor in a supercritical state or which is heated and pressurized in the reactor to attain a supercritical state. After mixing for a period of time, the slurry either is left in the reactor or is discharged into a receiving vessel. The process medium is separated from the polymers and removed, leaving behind finely divided particles.

Mixing assembly to combine a gas and a liquid in a supercritical range has a lens sealing unit with a venturi jet and a diffuser to take the gas feed with a liquid feed in a sealed link to the outflow pipe for the mixture

To mix together a gas and a liquid component, in a supercritical range, the inflow pipe (2) for the gas component and the outflow pipe (3) for the mixture are linked together through a sealing lens unit (10), with a venturi jet (12) followed by a diffuser (15). To mix together a gas and a liquid component, in a supercritical range, the inflow pipe (2) for the gas component and the outflow pipe (3) for the mixture are linked together through a sealing lens unit (10), with a venturi jet (12) followed by a diffuser (15). A feed drilling (18) is through the sealing lens unit, at right angles to the axes of the venturi jet and diffuser, connected to the feed channel for the liquid component, and linked to the jet drillings (21) at the narrowest cross section (14) of the venturi jet.

System for forming aerosols and cooling device incorporated therein

The present invention relates a cooling device of the reverse Carnot cycle-type using a refrigerant, and an aerosol generation system including it. The cooling device includes a refrigerator of the reverse Carnot cycle-type, a cleaning medium conduit, a temperature sensor, and a heater. The intermediate portion of the cleaning medium conduit and the evaporator are wound like a coil in the same configuration so as to maximize the contacting area therebetween. The temperature sensor measures the temperature of the carbon dioxide discharged from the cooling device, and the heater is arranged to contact the evaporator of the refrigerator and the intermediate portion of the cleaning medium conduit so as to precisely adjust the liquefying rate of the carbon dioxide according to the temperature measured by the temperature sensor. The carbon dioxide is refrigerated at a temperature in the range of −80° C. to −100° C. through the cooling device, transformed into liquid phase.

Instrument for automated sample preparation by combination homogenization and clarification

Disclosed herein are instruments and methods for performing both sample homogenization and sample clarification by centrifugation with a single instrument without transferring the sample to a new sample container and without removing or repositioning the sample container within the instrument. In some embodiments, the instrument may automatically perform centrifugation after homogenization. In other embodiments, the instrument may perform both homogenization and centrifugation simultaneously.

Insoluble drug delivery

Particles of water insoluble biologically active compounds, particularly wat er- insoluble drugs, with an average size of 100 nm to about 300 nm, are prepared by dissolving the compound in a solution then spraying the solution into compressed gaz, liquid or supercritical fluid in the presence of appropriate surface modifiers.

Counter current mixing reactor

A mixing reactor for mixing efficiently streams of fluids of differing densities. In a preferred embodiment, one of the fluids is supercritical water, and the other is an aqueous salt solution. Thus, the reactor enables the production of metal oxide nanoparticles as a continuous process, without any risk of the reactor blocking due to the inefficient mixing inherent in existing reactor designs.

Method And Apparatus For Producing Particles Via Supercritical Fluid Processing

An apparatus and method for producing particles using supercritical fluid with enhanced mixing. The process includes a vessel having an inner surface defining a chamber. A high-speed shear or turbulent mixer is incorporated inside the vessel in order to create a region of enhanced mixing (mixing zone). A supercritical fluid pump communicates with the first inlet, and supplies supercritical fluid into the mixing zone through the first inlet. A solution pump communicates with the second inlet, and supplies solution into the mixing zone through the second inlet. A mixer assembly includes a motor drive and a rotor. The rotor is in the mixing zone and can mix the solution and the supercritical fluid. Particles are produced when the solution and the supercritical fluid are pumped into the mixing zone while the rotor is mixing. The design of the mixer and the direction of the flow of materials into the chamber creates a plug flow in the mixing zone. The plug flow allows the particles to be removed from the mixing zone as soon as they are precipitated. Because of the high intensity homogeneous mixing and plug flow configuration, the particle uniformity is enhanced and production of composite particles facilitated.

Composite particle manufacturing apparatus and composite particle manufacturing method

【課題】 比較的大きい幅の流路によって構成され、粒子の吸着割合を調整可能とする複合粒子の製造装置を提供することであり、また、当該製造装置を用いた複合粒子の製造方法を提供する。【解決手段】 第１の流体を供給する少なくとも一つの第１の導入流路２と、第２の流体を供給する少なくとも一つの第２の導入流路３と、第１および第２の導入流路から供給される第１および第２の流体を合流させ、所定長さの範囲において二種類の流体を混合させつつ流下させる混合流路５とを備え、混合流路は、連続する流路であって、その連続する方向において流路断面積が不均一に形成されている。【選択図】 図２ PROBLEM TO BE SOLVED: To provide an apparatus for producing composite particles which is constituted by a channel having a relatively large width and which can adjust the adsorption ratio of particles, and to provide a method for producing composite particles using the production apparatus. Do. SOLUTION: At least one first inlet channel 2 for supplying a first fluid, at least one second inlet channel 3 for supplying a second fluid, and first and second inlet flows And a mixing channel 5 for mixing the first and second fluids supplied from the channel and causing the two types of fluid to flow down in a predetermined length range, and the mixing channel is a continuous channel. The flow passage cross-sectional area is formed unevenly in the continuous direction. [Selected figure] Figure 2

약액과 초임계유체의 혼합장치

본 발명은 혼합장치의 챔버 내부의 오염을 방지하면서 약액과 초임계유체 간의 혼합이 신속하고 원활하게 이루어져 기판 세정 시간을 단축할 수 있도록 하는 약액과 초임계유체의 혼합장치를 제공함에 그 목적이 있다. 이를 구현하기 위한 본 발명의 약액과 초임계유체의 혼합장치는, 기판을 세정하기 위한 약액과 초임계유체를 혼합하기 위한 혼합장치로서, 상기 약액과 초임계유체가 공급되어 혼합이 이루어지는 챔버; 및 상기 챔버의 외부에 구비되어 상기 챔버 내부의 약액과 초임계유체에 진동을 일으켜 혼합이 이루어지도록 하는 진동 발생부;를 포함하여 구성된다.

连续式超临界发泡及混练押出设备

一种连续式超临界发泡及混练押出设备，适用于将熔融态的原料押出成型，并包含第一混练单元、第一进气单元，及押出单元。该第一混练单元包括第一管、可转动地设置于该第一管内并用于推进该原料的第一螺杆，以及用于与该第一螺杆配合挤压并推进该原料的辅助螺杆，该辅助螺杆的转速为该第一螺杆的转速的两倍以上。该第一进气单元用于将气体注入该第一管内。通过该辅助螺杆配合该第一螺杆，能产生良好的搅拌、挤压、推进效果，可避免原料产生的水蒸气朝进料处流动，使进料过程顺畅，并使注入的气体与原料充分且均匀的混合，混练效果佳。

Metodos y aparatos para suministro de droga usando soluciones supercriticas.

Métodos y aparatos para suministrar compuestos fisiológicamente activos a un ser humano o animal de blanco emplean una solución de fluido supercrítico que comprende un solvente de fluido supercrítico y un soluto fisiológicamente activo. La solución de fluido supercrítico se hace pasar hacia una región subcrítica para evaporar el solvente y formar una dispersión llevada en el gas de las partículas del soluto.

Chemische reaktionen in umkehr-micellen-systemen

Gegenstrom-mischreaktor und darauf bezogener prozess

Carbon dioxide fluidity control device and method

Provided is a carbon dioxide fluidity control device comprising, a sample preparation tank, a high-pressure stirring unit, a reciprocating plunger pump and a booster pump, wherein the stirring unit comprises one or more high-pressure stirring tanks, each provided with an atomizing spray probe and a piston, wherein a discharge port of the sample preparation tank is connected to the atomizing spray probe via a plunger pump, which is connected to the piston to push the piston to reciprocate; the booster pump is connected to the high-pressure stirring tanks to provide supercritical carbon dioxide to the high-pressure stirring tank; and a discharge port of the high-pressure stirring tanks is connected to an oilfield well group. Provided is a carbon dioxide fluidity control method using the device, comprising mixing surfactants and nanoparticles with heated carbon dioxide, and injecting a microemulsion of supercritical carbon dioxide and nano-silicon dioxide into an oilfield well group.

Emulgier-/dispergiersystem

Reaction method with homogeneous-phase supercritical fluid

A reaction method with a homogeneous-phase supercritical fluid includes introducing a first fluid into a mixing chamber. A mass is less than or equal to that can be absorbed by the molecular sieve component, totally absorbing the first fluid by the molecular sieve component. A second fluid is introduced into the mixing chamber with a mass being greater than that can be absorbed by the molecular sieve component. A temperature and a pressure in the mixing chamber are adjusted to a critical temperature and a critical pressure of the second fluid, respectively, releasing the first fluid in supercritical phase from the molecular sieve component into the mixing chamber, followed by homogeneously mixing with the second fluid in supercritical phase in the mixing chamber to obtain a homogeneous-phase mixing fluid. The homogeneous-phase mixing fluid is then introduced into a reaction chamber connected to the mixing chamber.

Verabreichung unlöslicher arzneistoffe

Process for the formation of particulate material

A process for the formation of particulate material of a desired substance including: (i) charging a vessel with a supercritical fluid ; (ii) agitating the contents of the vessel with a rotary agitator, creating a relatively highly agitated zone and a bulk mixing zone ; (iii) introducing into the agitated vessel a first feed stream comprising a solvent and the desired substance and a second feed stream comprising the supercritical fluid, wherein the desired substance is less soluble in the supercritical fluid relative to tis solubility in the solvent, the first and second feed streams are introduced into the highly agitated zone of the vessel and the first feed stream is dispersed in the supercritical fluid by action of the rotary agitator, allowing extraction of the solvent into the supercritical fluid, and (iv) precipitating particles of the desired substance in the vessel with a volume-weighted average diameter of less than 100 nanometers.

Dissolving device and method for dissolving a particulate solid in a supercritical or almost critical fluid and dyeing device

A dissolving device for dissolving a particulate solid in a supercritical or almost critical fluid comprises a circulation loop, in which there is a feed for feeding a feed stream of the supercritical or almost critical fluid, a cyclone, which is in communication with the feed and has a principal discharge for discharging a principal discharge stream of a solution of the particulate solid in the supercritical or almost critical fluid and has an auxiliary discharge for discharging an auxiliary stream of the supercritical or almost critical fluid with solid particles dispersed therein, the auxiliary discharge being in communication with the said feed. A dissolving device of this type has a low pressure drop and a high dissolving rate compared to the prior art.

Neues verfahren zur herstellung von partikeln wasserunlöslicher komponenten im grössenbereich bis 2000 nm

processo para a preparação de suspensões de sais de cálcio e método para a incorporação de cálcio em bebidas alimentícias, nutracêuticas e farmacêuticas

processo para a preparação de suspensão de sais de cálcio e método para a incorporação de cálcio em bebidas alimentícias, nutracêuticas e farmacêuticas. a presente invenção está relacionada com um processo para a produção de suspensão aquosas de micro e nanopartículas de sais de cálcio com tamanhos inferiores a 10 micrômetros (109m) e com um método para o enriquecimento de bebidas alimentícias, nutracêuticas e farmacêuticas com sais de cálcio. no processo submete-se uma suspensão aquosa do sal de cálcio a pressurização com dióxido de carbono crítico, subcritico ou supercritico para incrementar a solubidade do sal de cálcio que apresenta tamanho de partícula superior a 30 <109>m. a solução resultante expande-se através de uma boquilha para gerar uma suspensão de micro e nanopartículas do sal de cálcio que se torna imperceptível à vista e ao sabor.

Apparatus for mixing materials dissolved in a high-pressure working fluid

The present invention relates to a mixing apparatus. A production unit produces a working fluid that is in a supercritical state or a subcritical state. A storage unit stores a material. A dissolving unit dissolves the material in the working fluid. A mixer mixes the material together in the presence of the working fluid. A material feed valve opens or closes a flow passage through which the material is to pass to be fed from the storage unit into the dissolving unit. A working fluid inflow valve opens or closes a flow passage through which the working fluid is to pass to flow into the dissolving unit from the production unit. A mixer inflow valve opens or closes a flow passage through which the working fluid and the material are to pass to flow into the mixer from the dissolving unit.

Verfahren und vorrichtung zur hochdruckausgabe einer fluidmischung

Size-varying bubble complex and method of preparing the same

Proposed is to provide a size-varying bubble complex and a method of preparing the same. More specifically, the size-varying bubble complex and the method of preparing the same are proposed, wherein the bubble complex is capable of being repeatedly varied in size by changing phases of perfluorocarbon by external stimuli, by including a shell that encapsulates a core made of the perfluorocarbon and protects the core by expanding and contracting together when the core expands and contracts.