12-05-2016 дата публикации
Номер: US20160129157A1
Принадлежит:
In one aspect, the invention provides an implantable device comprising a uniform mixture of components including degradable polymer, inorganic bone particulate either natural or synthetic, a drug, and a soluble microporagen. In some embodiments, the uniform mixture further includes a soluble polymer macroporagen. In some embodiments, the uniform mixture is coated with an immobilized outer porous layer comprising or consisting of synthetic or natural inorganic bone granules. In further aspects, the invention provides an implantable device comprising a composite core of degradable polymer, bone, and a drug, and a coating comprising or consisting of microporous bone overlayer covering the degradable composite core. 1. An implantable device comprising a uniform mixture of components including degradable polymer , bone , a drug , and a microporagen.2. The device of claim 1 , wherein the device further comprises a macroporagen in the uniform mixture.3. The device of claim 1 , wherein the bone is synthetic bone.4. The device of claim 1 , wherein the microporagen is selected from the group consisting of CaCl claim 1 , MgCl claim 1 , MgCO claim 1 , KCl claim 1 , NaCl claim 1 , CaCO claim 1 , and calcium sulfate5. (canceled)6. The device of claim 2 , wherein the macroporagen is selected from the group consisting of PEG claim 2 , alginate claim 2 , polyvinylpyrrolidone claim 2 , NaCMC claim 2 , hydroxypropylcelluose claim 2 , and hyaluronic acid.7. (canceled)8. The device of claim 2 , wherein the macroporagen and the polymer are not the same.9. The device of claim 1 , further comprising a coating covering the uniform mixture.10. The device of claim 1 , wherein the coating comprises or consists essentially of bone.11. The device of claim 1 , wherein the drug is microencapsulated.1215-. (canceled)16. The device of claim 1 , wherein the bone is present in a first amount claim 1 , the polymer is present in a second amount claim 1 , the drug is present in a third amount claim 1 , ...
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