15-03-2018 дата публикации
Номер: US20180072671A1
Принадлежит:
The present invention relates to compounds of formula (I): 2. A compound of or a pharmaceutically acceptable salt claim 1 , hydrate claim 1 , solvate claim 1 , or prodrug thereof claim 1 , wherein{'sub': 1', '2', '3', '4', '1', '2', '3', '4, 'W, W, W, and Ware each independently selected from hydrogen, chlorine, fluorine, and deuterium, provided that at least one of W, W, W, and Wis not hydrogen;'}{'sub': 1', '5', '1', '3, 'Xand Xare each independently selected from hydrogen, halogen and C-Calkyl;'}{'sub': 2', '3', '4', 'p', 'p', '1', '8', '2', '8', '2', '8', '3', '8', '4', '8', '2', '3', '4, 'sup': 5', '6', '7', '1', '7', '3', '4', '1', '2', 'a, 'X, X, and Xare each independently selected from hydrogen, halogen, OR, C(O)R, OS(O)R, NRS(O)R, NRR, NRC(O)R, C-Calkyl, C-Calkenyl, C-Calkynyl, C-Ccycloalkyl, C-Ccycloalkenyl, aromatic ring, 3-8 membered heteroaromatic ring, and 3-8 membered saturated or partially saturated heterocyclic ring, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aromatic ring, heteroaromatic ring, and heterocyclic ring is unsubstituted or substituted with one or more Rand one or two of X, X, and Xis hydrogen;'}{'sup': a', '25', '26', '27', '28', '29, 'sub': 1', '8', '3', '2', '2, 'Ris selected from halogen, OR, C-Calkyl, CF, CHF, CHF, NRC(O)R, and NRR; or'}{'sup': 1', '26, 'sub': 1', '8, 'Rand Rare each independently selected from hydrogen and C-Calkyl;'}{'sup': 2', 'b, 'sub': 1', '8', '2', '8', '3', '8', '3', '8', '4', '8, 'Ris selected from hydrogen, C-Calkyl, C-Calkenyl, C-Calkynyl, C-Ccycloalkyl, C-Ccycloalkenyl, aromatic ring, 3-8 membered heteroaromatic ring, and 3-8 membered saturated or partially saturated heterocyclic ring, wherein said alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aromatic ring, heteroaromatic ring, and heterocyclic ring are unsubstituted or substituted with one or more R;'}{'sup': 27', 'b, 'sub': 1', '8', '3', '8', '3', '8', '4', '8, 'Ris selected from hydrogen, C-Calkyl, C-Calkynyl, C-Ccycloalkyl, ...
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