СПОСОБ ВЫДЕЛЕНИЯ ИНГЕНОЛА

... 1. Способ выделения ингенола из смеси дитерпеноидных сложных эфиров и сложных эфиров ингенола, объединяющий фазы гидролиза сложных эфиров ингенола и экстракции/выделения ингенола из указанной смеси в одну стадию.2. Способ по п. 1, где смесь дитерпеноидных сложных эфиров и сложных эфиров ингенола подвергают одной стадии комбинированной обработки раствором подкисленной воды и органического растворителя.3. Способ по п. 1, где соотношение подкисленной воды и органического растворителя составляет 1:1.4. Способ по п. 1, где органический растворитель представляет собой THF (тетрагидрофуран).5. Способ по п. 1, где подкисленная вода содержит неорганические соли.6. Способ по п. 1, где подкисленная вода содержит NaCl.7. Способ по п. 1, характеризующийся тем, что раствор подкисленной воды и органического растворителя состоит из комбинации 2 н. HSOи HO с NaCl, 35% мас./об., в соотношении 1:1.8. Способ по любому из пп. 1-7, дополнительно включающий дополнительную фазу очистки выделенного ингенола.9.

3-АЦИЛИНГЕНОЛЫ II

... 1. Соединение общей формулы Iгде R представляет собой арил, замещенный одним или несколькими заместителями, независимо выбранными из R3;или R представляет собой (С-C)-циклоалкил, (С-C)-циклоалкенил или (С-C)-циклоалкинил, каждый из которых может быть необязательно замещен одним или несколькими заместителями, независимо выбранными из R4;R3 представляет собой галоген, циано, гидроксил;или R3 представляет собой (С-С)-алкил, (С-С)-алкенил, (С-С)-алкинил, (С-С)-циклоалкил, гетероциклоалкил, арил, гетероарил, каждый из которых может быть необязательно замещен одним или несколькими заместителями, независимо выбранными из R5;или R3 представляет собой -NRaCORb, -CONRaRb, -COORc, -OCORa,-ORa, -OCONRaRb, -NRaCOORb, -NRaCONRaRb, -NRaSONRaRb, -NRaSORb, -SONRaRb, -SORa, -S(О)Ra, -SRa или -NRdRe;R5 представляет собой галоген, циано, гидрокси, (С-С)-алкил, галоген(С-С)-алкилили R5 представляет собой -NRaCORb, -COORc, -OCORa, -CONRaRb, -OCONRaRb, -NRaCOORb, -NRaCONRaRb, -NRaSONRaRb, -NRaSORb,-SONRaRb, - ...

TRICYCLI STEROIDHORMONKERNREZEPTOR MODULATORS

PRODUCTION OF KETONHALTIGEN CYCLI CONNECTIONS

ELECTRICAL LUMINESCENCE DEVICE

PROCEDURE FOR the PRODUCTION OF NEW ONE 8-AMINO-ALK ALKYLTETRACYCLONONANEN AND OF THEIR ACID ADDITION SALTS

APHIDICOLANDERIVATE, YOUR PRODUCTION AND IT ABSTENTION PHARMACEUTICAL COMPOSITIONS.

Procedure for the production of new more-full of seeds Polyenverbindungen

PHENOLIC CONNECTIONS AS WELL AS YOUR GLYCIDYLETHER

Polycyclic arthropodicides

3-acyl-ingenols II

The invention relates to compounds of general formula I, (I), wherein R is wherein R is aryl substituted by R3; or R is (C3-Ci3)-cycloalkyl, (C3-Ci3)- cycloalkenyl or (C7-Ci3)-cycloalkynyl optionally substituted by R4; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use -alone or in combination with one or more other pharmaceutically active compounds- in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.

Anthelmintic beta -ketoamides

TETRACYCLONONANE DERIVATIVES

The invention relates to processes for preparing a new tetracyclononane derivative of the formula: II wherein R1, R2 and R3 are hydrogen atoms or alkyl radicals and A is -CH2-CH2- or ? CH-R4 in which R4 is a hydroqen atom or an alkyl, cyclohexyl, phenyl-alkyl or optionally-substituted phenyl radical, or a pharmaceutically acceptable acid addition salt thereof, provided that when A is a radical of the formula ? CH-R4, at least one of R1, R2, R3 and R4 is other than a hydrogen atom; or a pharmaceutically-acceptable acid-addition salt thereof. Typical of the compounds disclosed is 8-(1-amino-ethyl)tetracyclo ¢4,3.0,02,4,03,7!nonane. The compounds are active against viruses such as the influenza viruses.

COMPOUNDS AND METHODS OF TREATING RNA-MEDIATED DISEASES

The present invention provides compounds, compositions thereof, and methods of using the same.

NEW CLASS OF COMPOUNDS HAVING A VARIABLE SPECTRUM OF ACTIVITIES FOR CAPSAICIN-LIKE RESPONSES, COMPOSITIONS AND USES THEREOF

... 2057917 9015055 PCTABS00002 The present invention relates to a new class of compounds having a variable spectrum of activities for capsaicin-like responses, compositions thereof, processes for preparing the same, and uses thereof. Compounds of the invention are prepared by combining phorbol related diterpenes and homovanillic acid analogs via esterification at the exocyclic hydroxy group of the diterpene. Examples of these compounds include 20-homovanillyl-mezerein and 20-homovanillyl-12-deoxyphorbol-13-phenyl-acetate.

Verfahren zur Herstellung von Octahydro-1,2,4-methenopentalen-5-carbonsäure-nieder-alkoxyalkylestern

Procédé de fabrication d'hydrocarbures polyéniques polycycliques

Sedative and tranquillising 9-aminomethyl - 9,10 ethano anthracenes

New compds. of formula (I):- (where R1 is OMe, NO2 or NH2, R2 is H or Me) also their acid addition salts are used as CNS depressants, esp. as sedatives, anti-depressants and tranquillisers, in oral doses of 10-100 mg./kg. Also used in animal foodstuffs as a growth promoter and as intermediates.

Polycyclic compositions

Norbornene Derivative and Norbornene Polymer Obtained therefrom through Ring-Opening Polymerization

Ether, polymer, resist composition and patterning process

An ether compound of formula (1) is provided in which R1 is H or C1-6 linear, branched or cyclic alkyl, R2 is C1-6 linear, branched or cyclic alkyl, R3 is H, C1-15 acyl or C1-15 alkoxycarbonyl which may be substituted with halogen atoms, k is 0 or 1, m is from 0 to 3, and n is from 3 to 6. The ether compound is polymerized to form a polymer having improved reactivity, robustness and substrate adhesion. A resist composition comprising the polymer as a base resin is sensitive to high-energy radiation, has excellent sensitivity, resolution, and etching resistance, and lends itself to micropatterning with electron beams or deep-UV. The resist material has low absorption particularly at an exposed wavelength of an ArF excimer laser or a KrF excimer laser and therefore can easily form a fine pattern perpendicular to a substrate.

Tetracyclic alcohols

Described is a genus of novel compounds, defined by the generic structure: ...

Polycyclische Polyenkohlenwasserstoffe und Verfahren zu ihrer Herstellung

PROCESS FOR PRODUCING POLYCYLINIC DIOLS

PLASTOMERS DERIVED FROM DIMETHANOOCTAHYDRONAPHTHALENE AND THEIR METHOD OF MANUFACTURE

... 1,208,371. Dimethano-octahydronaphthalenes. CHARBONNAGES DE FRANCE. 11 Jan., 1968 [12 Jan., 1967], No. 1690/68. Heading C5E. [Also in Division C3] 1,4,5,8 - Dimethano - 1,2,3,4,4a,5,8,8a - octahydronaphthalene (DMON) is prepared by condensing norbornene with cyclopentadiene (in the form of dicyclopentadiene):- C 1 -C 4 alkyl derivatives substituted in the 3-position may be prepared either by direct Diels-Alder reaction of the corresponding 5- alkyl norbornene with cyclopentadiene or by indirect Diels-Alder synthesis; e.g. methyl- DMON from propylene and cyclopentadiene, n-butyl-DMON from 1-hexene and cyclopentadiene, and iso-butyl-DMON from 4-methyl- 1 - pentene and cyclopentadiene.

Improvements in or relating to 1,2-Methylene-B-Norsteroids

... 1,156,130. B-Nor-steroids. SMITH KLINE & FRENCH LABORATORIES. 19 Sept., 1967 [21 Sept., 1966], No. 42706/67. Headings C2C and C2U. Novel compounds of formula or C(H)(- or #-CH 3 ) and R1 is hydrogen, methyl, or ethyl, and the 17-esters thereof, are prepared by adding a 1,2-methylene group (e.g. with dimethyl sulphoxonium methylide) across the 1,2-double bond of the corresponding B-nor-1,4-androstadien-3-one, which in turn is obtained by chemical or microbiological dehydrogenation of the corresponding B-norandrost-4-en-3-one, e.g. using Septomyxa affinis. The 17-esters of the invention are obtainable from the 17-ols by conventional acylation. 6,6 - Ethylene - 17# - hydroxy - 17 - methyl- # - nor - androst - 4 - en - 3 - one is prepared by the sequence: 17 - methylandrost - 5 - ene- 3#,17# - diol-#its 3,17-diacetate-#3#,17#- diacetoxy - 17 - methyl - 5,6 - seco - androstan- 5 - on - 6 - al-#the corresponding 6 - oic acid-#3#,17# - diacetoxy - 17 methyl - 5#- hydroxy - # - nor - androstan ...

NEW CLASS OF CONNECTIONS WITH VARIABLE SPECTRUM OF ACTIVITY FOR CAPSAICINÄHNLICHEN REACTIONS, YOUR COMPOSITIONS AND YOUR APPLICATIONS

SORDARINDERIVATE

PROCEDURE FOR THE PRODUCTION OF NORBORNENEN AND SUBSTITUTED NORBORNENENDERIVATE

TETRACYCLONONANE DERIVATIVES

SUBSTITUTED AROMATIC HYDROCARBONS, PROCESSES FOR PRODUCTION THEREOF, AND USE THEREOF AS ADHESIVE ADDITIVES

INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES

The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is -NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use -alone or in combination with one or more other pharmaceutically active compounds- in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.

A METHOD OF PRODUCING INGENOL-3-ANGELATE

Даний винахід стосується способів отримання інгенол-3-ангелату (І) з інгенолу (II). Крім того, винахід стосується проміжних продуктів, застосовних для синтезу інгенол-3-ангелату (І) з інгенолу (II), і способів отримання вказаних проміжних продуктів. The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). In addition, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II), and methods for producing said intermediates.

TRICYCLIC MODULATORS OF STEROID HORMONE NUCLEAR RECEPTOR

M-xylylenediamide bridging chiral molecular clamp and preparation and application thereof

Method for producing bifunctional compound having norbornane skeleton

The present invention provides a method for producing a bifunctional compound having a norbornane skeleton, the method comprising a step of hydroformylating a compound having an olefin with carbon monoxide and hydrogen, wherein the molar ratio of the carbon monoxide to the hydrogen during the reaction is 55/45 or more and 95/5 or less in the hydroformylating step.

ИНГЕНОЛ-3-АЦИЛАТЫ III И ИНГЕНОЛ-3-КАРБАМАТЫ

Изобретение относится к соединению общей структурной формулы I, которое может быть использовано для предотвращения, лечения, облегчения течения или профилактики физиологических расстройств или заболеваний, связанных с гиперплазией или неоплазией. В формуле (I) R обозначает 5-10-членный моно- или бициклический гетероарил, содержащий 1-3 гетероатома, выбранных из О, N и S, который может быть необязательно замещен одним или более заместителями, независимо выбранными из R7; или R обозначает 5-10-членный гетероциклоалкил, содержащий 1-2 гетероатома, выбранных из О, N и S, или 5-10-членный гетероциклоалкенил, содержащий 1-2 гетероатома, выбранных из О, N и S, где указанный 5-10-членный гетероциклоалкил или 5-10-членный гетероциклоалкенил необязательно замещены одним или более заместителями, независимо выбранными из R8; или R обозначает X; R7 представляет галоген; или R7 представляет (C-C) алкил, (С-С) алкенил, (С) циклоалкил, 6-членный гетероциклоалкил, содержащий 1 гетероатом, выбранный из N ...

ПРОИЗВОДНЫЕ ТАКСАНА, СПОСОБ ИХ ПОЛУЧЕНИЯ, ФАРМКОМПОЗИЦИЯ

Получение новых 3, 11-циклотаксанов, имеющих общую формулу I. Циклотаксан формулы Ia может быть выделен из растений рода Taxus (соединение формулы I, в котором R'=R''=H). Новые циклотаксаны формулы I обладают противоопухолевой активностью. 3 с. и 6 з.п. ф-лы, 1 табл.

КРИСТАЛЛИЧЕСКИЙ ИНГЕНОЛ МЕБУТАТ

... 1. Кристаллический ингенол мебутат.2. Кристаллический ингенол мебутат по п. 1, где кристаллическая форма не является сольватом.3. Кристаллическая форма по п. 1, которая является орторомбической.4. Кристаллическая форма по п. 1, которая принадлежит к пространственной группе P222.5. Кристаллическая форма по п. 1, дополнительно характеризующаяся FTIR-ATR спектром, демонстрирующим пики в спектре нарушенного полного внутреннего отражения с частотами приблизительно при 3535, 2951, 1712, 1456, 1378, 1246, 1133, 1028 и/или 956 см(±3 см).6. Кристаллическая форма по п. 1, кривая которой, полученная с помощью дифференциальной сканирующей калориметрии, демонстрирует скачок при температуре около 153±5°C.7. Кристаллическая форма по п. 1, которую получают путем кристаллизации соединения формулы 1 из ацетона, ацетонитрила, этанола, 2-пропанола, гептана, метил трет-бутилового эфира, моноглима, толуола, смеси ацетона и гептана, смеси ацетона и c-гексана, смеси ацетона и i-октана, смеси ацетона и ксилола, ...

СПОСОБ ПОЛУЧЕНИЯ ИНГЕНОЛ-3-АНГЕЛАТА

... 1. Способы получения ингенол-3-ангелата (I) из ингенола (II).2. Способ получения ингенол-3-ангелата по п.1 (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-дигидрокси-4-(гидроксиметил)-1,1,7,9-тетраметил-11-оксо-1а,2,5,5а,6,9,10,10а-октагидро-1Н-2,8а-метаноциклопента[a]циклопропа[e]циклодецен-6-илового сложного эфира 2-метил-2(Z)-бутеновой кислоты) (I) из ингенола (II),содержащий следующие стадии:(а) реакция одной или обеих гидроксильных групп в положениях 5 и 20 ингенола с подходящими гидроксилзащищающими агентами, одинаковыми или разными, с получением соединения общей формулы (III) или (IV)в которых Rпредставляет собой водород или гидроксилзащитную группу и Rпредставляет собой водород или гидроксилзащитную группу, при условии, что Rи Rодновременно не представляют собой водород, или в которых D представляет собой дигидроксилзащитную группу,(b) этерификация гидроксильной группы в положении 3 соединений (III) или (IV) с получением соединений общей формулы (V) или (VI)в которых R, Rи D имеют значения, ...

ИЗОМЕРЫ СТЕВИОЛ-ГЛИКОЗИДОВ

FIELD: chemistry. SUBSTANCE: invention relates to compounds of formula II: where R 1 can be 1-β-D-glucopyranosyl or 2-(1-β-D-glucopyranosyl)-1-β-D-glucopyranosyl, and R 2 can be hydrogen, 1-β-D-glucopyranosyl, 2-(1-β-D-glucopyranosyl)-1-β-D-glucopyranosyl, 2,3-bis(1-β-D-glucopyranosyl)-1-β-D-glucopyranosyl, 2-(1-α-L-rhamnopyranosyl)-1-β-D-glucopyranosyl, 2-(1-α-L-rhamnopyranosyl)-3-(1-β-D-glucopyranosyl)-1-β-D-glucopyranosyl, or 2-(1-β-D-xylopyranosyl)-3-(1-β-D-glucopyranosyl)-1-β-D-glucopyranosyl. EFFECT: compounds can be used as sweetening agents which do not have nutritional qualities in food and drinks. 35 cl, 8 ex, 23 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 430 102 (13) C1 (51) МПК C07H C07H C07C A23L A23L 15/24 13/08 62/32 1/236 2/60 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2010107991/04, 04.09.2008 (24) Дата начала отсчета срока действия патента: 04.09.2008 (73) Патентообладатель(и): ПепсиКо, Инк. (US) R U Приоритет(ы): (30) Конвенционный приоритет: 17.09.2007 US 11/856,274 (72) Автор(ы): ЛЕЕ Томас (US) (45) Опубликовано: 27.09.2011 Бюл. № 27 C 1 2 4 3 0 1 0 2 R U C 1 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 05.03.2010 (86) Заявка PCT: US 2008/075192 (04.09.2008) (87) Публикация заявки РСТ: WO 2009/038978 (26.03.2009) Адрес для переписки: 127006, Москва, ул. Долгоруковская, 7, Садовая Плаза, 11 этаж, фирма "Бейкер и Макензи", патентному поверенному Ю.А.Пыльневу (54) ИЗОМЕРЫ СТЕВИОЛ-ГЛИКОЗИДОВ (57) Реферат: Данное изобретение соединениям формулы II относится к Ñòð.: 1 ru 2 4 3 0 1 0 2 (56) Список документов, цитированных в отчете о поиске: М. Kobayashi et al, "Dulcosides A and B, new diterpene glycosides from Stevia Rebaudiana", Phytochemistry, 1977, v.16, pp.1405-1408. Hanson J.R. et al, "The microbiological transformation of steviol derivatives by rhizopus stolinifer and gibberella fujikuroi", ...

ИНГЕНОЛ-3-АЦЕЛАТЫ I

... 1. Соединение общей формулы Iгде R представляет собой (C-C)алкил, (C-C)алкенил или (C-C)алкинил, где R замещен одним или несколькими заместителями, независимо выбранными из R1; где R1 представляет собой(а) фтор, циано или гидрокси; или(b) (C-C)алкил, циклоалкил, циклоалкенил, арил, гетероарил, гетероциклоалкил, гетероциклоалкенил или (C-C)циклоалкилиден, каждый из которых может быть необязательно замещен одним или несколькими заместителями, независимо выбранными из R2, где R2 представляет собой галоген, циано, гидрокси, (C-C)алкил, (C-C)алкенил, галоген(C-C)алкил, -NRaCORb, -COORc, -OCORa, -CONRaRb, -OCONRaRb, -NRaCOORb, -NRaCONRaRb, -NRaSORb, -NRaSONRaRb, -SONRaRb, -SORa, -S(О)Ra, -ORa, -SRa, =N-ORa, =О; или(с) -NRaCORb, -COORc, -OCORa, -CONRaRb, -OCONRaRb, -NRaCOORb, -NRaCONRaRb, -NRaSORb, -NRaSONRaRb, -SONRaRb, -SORa, -S(О)Ra, -ORa, -SRa, =N-ORa, -NRaRb или =О;и гдеRa и Rb независимо представляют собой водород, (C-C)алкил, галоген(C-C)алкил, (C-C)алкокси(C-C)алкил, гидрокси(C-C)алкил ...

New derivative of 1,3,4-metheno-2h-cyclobuta (cd) pentalen-2-ol

The invention comprises decachlorooctahydro - 1,3,4 - methano - 2H - cyclobuta (cd) pentalen-2-ol of the formula also carbamates, inorganic ester or organic monocarboxylic esters thereof. The alcohol is prepared by refluxing the corresponding ketone with a metallic hydride in the presence of an inert solvent under substantially anhydrous conditions at a temperature of 50 DEG to 175 DEG C. Any metallic hydride may be used but NaBH4 and LiAlH4 are preferred. The solvent may be an aromatic hydrocarbon or a high boiling ether. The alcohol may be converted into its derivatives by conventional methods and numerous examples are given.ALSO:A pesticidal composition comprises decachlorooctahydro - 1,3,4 - methano - 2H - cyclobuta (cd) pentalen-2-ol of the formula or a carbamate, inorganic ester or organic monocarboxylic ester thereof together with a solid or liquid carrier or diluent. Liquid compositions may contain 10% to 25% of active ingredient with an ...

POLYCYCLIC POLYENE HYDROCARBONS AND A PROCESS FOR THE PREPARATION THEREOF

... 1,264,048. Polycyclic polyene hydrocarbons. SNAM PROGETTI S.p.A. 10 Dec., 1969 [18 Dec., 1968], No. 60397/69. Heading C5E. The inventioncomprises per se polycyclic polyene hydrocarbons A-(CH 2 ) n -B where A is a radical comprising at least one ring having-anendomethylene group (whichmay carry two methyl substituents), B is a cyclodiene radical, and n is 0 or an integer from 1 to 5. They may be prepared by any of the following methods:- (a) reacting A-(CH 2 ) n -X, with MB where X is halogen and M is alkali metal; (b) reacting X-(CH 2 ) n -B with MA; (c) heating a product A-(CH 2 ) n -B to introduce additional rings thereinto, optionally in the presence of cyclopentadiene. In Examples 1-5, reaction (a) is used to prepare compounds I, II and III formulated below. Example 6 describes production of compound IV- by heating compound III in benzene solution. Example 7 describes production of compound V by heating compound III with cyclopentadiene in benzene solution. Other possible products are ...

TUBULIN POLYMERIZATION AND/OR - DEPOLYMERISATION AFFECTING BORNEOLDERIVATE

INTERLEUKIN-1UND TUMORNEKROSEFAKTOR AMODULATOREN, SYNTHESIS OF SUCH MODULATORS AND PROCEDURES WITH APPLICATION OF SUCH MODULATORS

Procedure for the production of new Octahydro-1,2,4-methenopentalen-5-carbonsäure-alkoxyalkylestern

Novel thio derivatives of sordarin as antifungal agents

Method of isolating ingenol

The present invention relates to a new method for isolating ingenol (C ...

Cubane derivatives as metabotropic glutamate receptor antagonists and process for their preparation

TETRACYCLONONAME DERIVATIVES

REACTION PRODUCTS OF AN OLEFIN, A NORBORNENE AND A CYCLOPENTADIENE

TAXANE DERIVATIVES, THEIR PREPARATION AND USE IN ONCOLOGY

The preparation of new 3,11-cyclotaxanes having the general formula I. wherein each of R' and R", independently of the other, is hydrogen, alkanoyl of 2 to 7 carbon atoms, -CO- CHOHCH(C6H5)NHCOC6H5, or -COCHOHCH(C6H5)NHCOOC(CH3)3. Cyclotaxane 1a (1, R'=R"=H) may be isolated from plants of the genus Taxus. New cyclotaxanes 1 have antiblastic activity.

COMPOUND HAVING ALICYCLIC STRUCTURE, (METH)ACRYLIC ACID ESTER, AND PROCESS FOR PRODUCTION OF THE (METH)ACRYLIC ACID ESTER

INGENOL-3-ACYLATES III AND INGENOL-3-CARBAMATES

Method for producing norbornene derivative

Disclosed is a method for producing a norbornene derivative, wherein a norbornadiene derivative represented by the general formula (3) below is reacted with a bromine compound represented by the general formula (4) below in the presence of palladium and at least one compound selected from the phosphorus compounds represented by the general formulae (1) and (2) below, thereby producing a norbornene derivative represented by the general formula (5) below wherein a substituent represented by Z is in the exo configuration. (In the formula (1), R1, R2, R3 and R4 independently represent a hydrogen atom or the like; and R5 and R6 independently represent a branched saturated hydrocarbon group having 3-10 carbon atoms or the like.) (In the formula (2), R7 represents a branched saturated hydrocarbon group having 3-10 carbon atom.) (In the formula (3), R8, R9, R10, R11 and R12 independently represent a hydrogen atom or the like; l represents an integer of 0 or 1; m represents an integer of 0 or 1; ...

ORGANIC COMPOUND AND ORGANIC LIGHT EMITTING DEVICE USING THE SAME

The present invention provides an organic light emitting device comprising a first electrode, at least one organic layer and a second electrode, laminated successively, in which at least one layer of the organic layer has a polycyclic aromatic hydrocarbon as a core and comprises at least one of a derivative in which a substituted or unsubstituted C2-30 cycloalkane, or a substituted or unsubstituted C5-50 polycycloalkane is directly fused to the core or fused to a substituent of the core: and a new organic compound usable in the organic light emitting device. Furthermore, the present invention provides a charge carrier extracting, injecting or transporting material which has a polycyclic aromatic hydrocarbon as a core and comprises a derivative in which a substituted or unsubstituted C2-30 cycloalkane, or a substituted or unsubstituted C5-50 polycycloalkane is directly fused to the core or fused to a substituent of the core.

Method of regioselective synthesis of substituted benzoates

A method of synthesis of para-substituted benzoate esters and acids is provided, wherein the para-substituted regioisomer is obtained substantially free of the meta-substituted impurity, the method comprising contacting a coumalate ester or acid and an unactivated alkene at elevated temperature in the presence of a metal oxidation catalyst and an oxidant. The metal oxidation catalyst can be palladium, such as palladium on carbon, and the oxidant can be the oxygen gas in ambient air. The reaction can be carried out without solvent or in high boiling hydrocarbon solvents such as mesitylene. When the unactivated alkene is a monosubstituted alkene, yields of at least about 50 or 60% of para-substituted ester and acid products, respectively, are obtained, substantially free of the regioisomeric meta-substituted impurity.

Estrogen receptor modulators

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as estrogen receptor modulators. The compounds of the instant invention are ligands for estrogen receptors and as such may be useful for treatment or prevention of a variety of conditions related to estrogen functioning including: bone loss, bone fractures, osteoporosis, metastatic bone disease, Paget's disease, periodontal disease, cartilage degeneration, endometriosis, uterine fibroid disease, hot flashes, increased levels of LDL cholesterol, cardiovascular disease, impairment of cognitive functioning, age-related mild cognitive impairment, cerebral degenerative disorders, restenosis, gynecomastia, vascular smooth muscle cell proliferation, obesity, incontinence, inflammation, inflammatory bowel disease, irritable bowel syndrome, sexual dysfunction, hypertension, retinal degeneration and cancer, in particular of the breast, uterus and prostate.

ИЗОМЕРЫ СТЕВИОЛ-ГЛИКОЗИДОВ

1. Соединение по формуле II:в котором Rявляется водородом, a Rявляется 2-(1-β-D-глюкопиранозил)-1-β-D-глюкопиранозилом, 2,3-бис(1-β-D-глюкопиранозил)-1-β-D-глюкопиранозилом, 2-(1-α-L-рамнопиранозил)-1-β-D-глюкопиранозилом, 2-(1-α-L-рамнопиранозил)-3-(1-β-D-глюкопиранозил)-1-β-D-глюкопиранозилом, или 2-(1-β-D-ксилопиранозил)-3-(1-β-D-глюкопиранозил)-1-β-D-глюкопиранозилом.2. Соединение по п.1, в котором Rявляется 2-(1-β-D-глюкопиранозил)-1-β-D-глюкопиранозилом.3. Соединение по п.1, в котором Rявляется 2,3-бис(1-β-D-глюкопиранозил)-1-β-D-глюкопиранозилом.4. Соединение по п.1, в котором Rявляется 2-(1-α-L-рамнопиранозил)-1-β-D-глюкопиранозилом.5. Соединение по п.1, в котором Rявляется 2-(1-α-L-рамнопиранозил)-3-(1-β-D-глюкопиранозил)-1-β-D-глюкопиранозилом.6. Соединение по п.1, в котором Rявляется 2-(1-β-D-ксилопиранозил)-3-(1-β-D-глюкопиранозил)-1-β-D-глюкопиранозилом.7. Соединение по п.1, в котором соединение является выделенным и очищенным.8. Питьевой продукт, содержащий:водосодержащую жидкость, исоединение по формуле II:в котором Rявляется водородом, a Rявляется 2-(1-β-D-глюкопиранозил)-1-β-D-глюкопиранозилом, 2,3-бис(1-β-D-глюкопиранозил)-1-β-D-глюкопиранозилом, 2-(1-α-L-рамнопиранозил)-1-β-D-глюкопиранозилом, 2-(1-α-L-рамнопиранозил)-3-(1-β-D-глюкопиранозил)-1-β-D-глюкопиранозилом, или 2-(1-β-D-ксилопиранозил)-3-(1-β-D-глюкопиранозил)-1-β-D-глюкопиранозилом.9. Питьевой продукт по п.8, выбранный из группы, состоящей из газированных напитков, негазированных напитков, напитков, приготовляемых автоматами, замороженных газированных напитков, порошковых концентратов, сухих концентратов, фруктовых соков, ароматизированных напитков с фруктовым соком, напитков с фруктовым ароматом, спортивных напитков, энергетических напитко� РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2011 124 563 (13) A (51) МПК C07H C07H C07C A23L A23L 15/24 13/08 62/32 1/236 2/60 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21 ...

NEUE BORNEOLDERIVATE, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE PHARMAZEUTISCHE VERWENDUNG

VERFAHREN ZUR HERSTELLUNG POLYCYCLISCHER DIOLE

Tractanten und Verwendungsverfahren

1,2-Methylen-B-norsteoride und Verfahren zu deren Herstellung

PROCEDURE FOR the PRODUCTION OF NEW ONE 8-AMINO-ALKYLTETRACYCLONONANEN AND OF THEIR SAEUREADDITIONSSALZEN

VERFAHREN ZUR HERSTELLUNG VON NEUEN 8-AMINO-ALK ALKYLTETRACYCLONONANEN UND VON DEREN SAEURE- ADDITIONSSALZEN

NEW BORNEOLDERIVATE, PROCEDURES FOR YOUR PRODUCTION AND YOUR PHARMACEUTICAL USE

TAXANDERIVATE, YOUR PRODUCTION AND YOUR APPLICATION IN THE ONKOLOGIE

STEVIOLGLYCOSIDISOMERE

Cubane derivatives as metabotropic glutamate receptor antagonists and process for their preparation

NEW CLASS OF COMPOUNDS HAVING A VARIABLE SPECTRUM OF ACTIVITIES FOR CAPSAICIN-LIKE RESPONSES, COMPOSITIONS AND USES THEREOF

APHIDICOLIN DERIVATIVES

A substance for the use in a dietary supplementation or for the preparation of amedicament for the treatment of non-insulin dependent diabetes mellitus, hypert ension and/or the metabolic syndrome

POLYMERIZATION OF BULKY NORBORNENE DERIVATIVES WITH A RING OPENING METATHESIS CATALYST SYSTEM AND POLYMERS OBTAINABLE THEREWITH

SUBSTITUTED AROMATIC HYDROCARBONS, PROCESSES FOR PRODUCTION THEREOF, AND USE THEREOF AS ADHESIVE ADDITIVES

An aromatic hydrocarbon in which at least one hydrogen atom on the ring is substituted by a group selected from the class consisting of unsubstituted or lower alkyl-substituted tricyclo¢5.2.1.02,6!dec-3-yl, tricyclo ¢5.2.1.02,6!dec-4-yl, tetracyclo¢6.2.1.13,6.02,7!dodec-4-yl and tetracyclo¢6.2.1.13,6.02,7!dodec-5-yl groups, or its hydrogenation product. The compound is prepared by reacting an aromatic hydrocarbon having at least one hydrogen atom on the ring with a compound selected from the group consisting of unsubstituted or lower alkyl-substituted tricyclo¢5.2.1.02,6!dec-3-ene and tetracyclo¢6.2.1.13,6.02,7!dodec-4-ene in the presence of a Friedel-Crafts catalyst, or hydrogenating the thus-obtained compound in the presence of a hydrogenation catalyst. The compound is useful as an additive for adhesives.

HOMOCYCLIC DERIVATIVES

A SUBSTANCE FOR THE USE IN A DIETARY SUPPLEMENTATION OR FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF NON-INSULIN DEPENDENT DIABETES MELLITUS, HYPERTENSION AND/OR THE METABOLIC SYNDROME

A substance including the chemical structures of bicyclo[3.2.1]octan or the chemical structures of kaurene for the use in a dietary supplementation or as a constituent in a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome. The unique chemical structures of bicyclo[3.2.1]octan alone or in a kaurene structure provides the substances, such as e.g. steviol, isosteviol and stevioside with the capability of enhancing or potentiating the secretion of insulin in a plasma glucose dependent manner. The substances including these unique chemical structures also have the capability of reducing the glucagon concentration in the blood and/or lowering the blood pressure thereby providing a self--regulatory treatment system for non-insulin dependent diabetes mellitus and/or hypertension. In a combination drug which also comprise a soy protein, and/or soy fiber and/or at least one isoflavone these substances act synergistically and such ...

STEVIOL GLYCOSIDE ISOMERS

Steviol glycoside isomers are provided having the formula: (see above formula) wherein R1 may be 1-.beta.-D-glucopyranosyl or 2-(1-.beta.-D-glucopyranosyl)-1-.beta.-D-glucopyranosyl, and R2 may be hydrogen, 1-.beta.-D-glucopyranosyl, 2-(1-.beta.-D-glucopyranosyl)-1-.beta.-D-glucopyranosyl, 2,3-bis(1-.beta.-D-glucopyranosyl)-1-.beta.-D-glucopyranosyl, 2-(1-.alpha.-L-rhamnopyranosyl)-1-.beta.-D-glucopyranosyl, 2-(1-.alpha.-L-rhamnopyranosyl)-3-(1-.beta.-D-glucopyranosyl)-1-.beta.-D-glucopyranosyl, or 2-(1.beta.-D-xylopyranosyl)-3-(1-.beta.-D-glucopyranosyl)-1-.beta.-D-glucopyranosyl. Methods for making steviol glycoside isomers are also disclosed. These compounds may be present in food and beverage products as non-nutritive sweeteners.

SORDARIN DERIVATIVES

Sordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops.

Application of euphorbia ebracteolata hayata D and E as miR-29a inhibitor and bone marrow mesenchymal stem cell apoptosis inhibitor

POLYMERIZATION OF BULKY NORBORNENE DERIVATIVES AND POLYMERS OBTAINABLE THEREWITH

POLYCYCLIC POLYENE HYDROCARBONS AND A PROCESS FOR THE PREPARATION THEREOF

Precursor of organic device material and manufacturing method thereof, ink, and organic EL element and manufacturing method thereof

A precursor of an organic device material is provided, which has a specific structure. The organic device material such as a light-emitting element material is broadly applicable to wet process, and is capable of providing a high-performance organic device.

PYRENE DERIVATIVE, ORGANIC LIGHT-EMITTING MEDIUM, AND ORGANIC ELECTROLUMINESCENT ELEMENT CONTAINING PYRENE DERIVATIVE OR ORGANIC LIGHT-EMITTING MEDIUM

An organic light-emitting medium including a pyrene derivative represented by the following formula (1) and a phenyl-substituted anthracene derivative represented by the following formula (2): 2. The organic light-emitting medium according to claim 1 , wherein Xto Xare a hydrogen atom.3. The organic light-emitting medium according to claim 1 , wherein Xand Xare a substituted or unsubstituted aryl group having 6 to 30 ring carbon atoms claim 1 , a substituted or unsubstituted alkyl group having 1 to 20 carbon atoms or a substituted or unsubstituted cycloalkyl group having 3 to 20 ring carbon atoms claim 1 , and X claim 1 , Xto X claim 1 , Xand Xare a hydrogen atom.4. The organic light-emitting medium according to any of to claim 1 , wherein Arand Aris a substituted or unsubstituted aryl group having 6 to 30 ring carbon atoms.5. The organic light-emitting medium according to any of to claim 1 , wherein Rand R claim 1 , or Rand Rare a substituted or unsubstituted aryl group having 6 to 30 ring carbon atoms.6. The organic light-emitting medium according to or claim 1 , wherein Arand Arare a substituted or unsubstituted phenyl group.7. The organic light-emitting medium according to or claim 1 , wherein Rand R claim 1 , or Rand Rare a substituted or unsubstituted phenyl group.8. The organic light-emitting medium according to any of to claim 1 , wherein m is 1 and n is 1.9. The organic light-emitting medium according to any of to claim 1 , wherein m is 0 and n is 1.10. The organic light-emitting medium according to claim 8 , wherein Aris a substituted or unsubstituted arylene group having 6 to 18 ring carbon atoms or a substituted or unsubstituted heteroarylene group having 5 to 20 ring atoms claim 8 , Aris a substituted or unsubstituted aryl group having 6 to 18 ring carbon atoms or a substituted or unsubstituted heteroaryl group having 5 to 20 ring atoms.11. The organic light-emitting medium according to claim 9 , wherein Aris a substituted or unsubstituted aryl group ...

Spiroketal-Based C2-Symmetric Scaffold For Asymmetric Catalysis

Provided herein is a compound of formula (I): 4. The compound of claim 1 , wherein at least one X is OH.5. (canceled)6. The compound of claim 1 , wherein at least one X is PAr.7. (canceled)8. The compound of claim 1 , wherein at least one X is OPAr.9. (canceled)10. The compound of claim 1 , wherein at least one X is P(O)Ar.1112.-. (canceled)13. The compound of claim 6 , wherein Ar comprises phenyl.14. The compound of claim 1 , wherein both X together form OPNR′.1518.-. (canceled)19. The compound of claim 14 , wherein R′ is methyl.2022.-. (canceled)23. The compound of claim 1 , wherein R is ethyl.2428.-. (canceled)29. The compound of claim 1 , wherein at least one R is 3-10 membered heterocycloalkyl having 1-4 heteroatoms independently selected from N claim 1 , O claim 1 , and S.3034.-. (canceled)36. A catalyst comprising the compound of formula (I) according to and a transition metal.37. The catalyst of claim 36 , wherein the transition metal comprises iridium claim 36 , palladium claim 36 , rhodium claim 36 , platinum claim 36 , copper claim 36 , nickel claim 36 , cobalt claim 36 , or gold.38. A method of preparing the catalyst of comprising admixing the compound of formula (I) and the transition metal to form the catalyst.39. (canceled)40. The method of claim 38 , wherein the transition metal comprises [Ir(COD)Cl] claim 38 , [Pd(allyl)Cl] claim 38 , or Pd(dba).41. The method of claim 38 , wherein the compound of formula (I) and the transition metal are provided in a molar ratio of about 6:1 to 1:1.42. A method comprising:{'claim-ref': {'@idref': 'CLM-00036', 'claim 36'}, 'admixing a first reactant, a second reactant, and the catalyst of under conditions sufficient to allow reaction of the first reactant and the second reactant to form a reaction product, wherein the reaction product comprises a chiral center and the reaction produces an enantiomeric excess (ee) of the reaction product.'}43. The method of claim 42 , wherein the reaction comprises a hydroarylation ...

MATERIALS FOR ELECTRONIC DEVICES

The present application relates to a polymer containing at least one structural unit of a formula (I). The polymer is suitable for use in an electronic device.

COMPOUND HAVING ALICYCLIC STRUCTURE, (METH)ACRYLIC ACID ESTER, AND PROCESS FOR PRODUCTION OF THE (METH)ACRYLIC ACID ESTER

Provided are an alicyclic structure-containing compound, a (meth)acrylate, and a method for producing the ester. The compound and the ester are useful as a monomer and the like for a photoresist used in semiconductor manufacturing and excellent in solubility, compatibility, defect reduction, roughness improvement, and the like, realized by using an alicyclic structure-containing compound containing a linking group having an ester bond and/or a linking group having an ether bond, a (meth)acrylate derived from the alicyclic structure-containing compound, and a method for producing the ester.

СПОСОБ ПОЛУЧЕНИЯ ИНГЕНОЛ-3-АНГЕЛАТА

FIELD: chemistry. SUBSTANCE: present invention relates to method of producing ingenol-3-angelate (I) from ingenol (II). Invention also relates to intermediate products used for synthesis of ingenol-3-angelate (I) from ingenol (II), and methods of producing said intermediate products. Method of producing ingenol-3-angelate (1aR,2S,5R,5aS,6S,8aS,9R,10aR)-5,5a-dihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-11-oxo-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8A-methanocyclopente[a]cycloprope[e]cyclodecen-6-yl ester 2-methyl-2(Z)-butenoic acid) of formula (I) from ingenol of formula (II) includes following steps: (a) reaction of one or both of hydroxyl groups in positions 5 and 20 ingenol with suitable hydroxyl protecting agents, which can be identical or different, to obtain compound of general formula (III) or (IV) in which R 1 represents hydrogen or hydroxyl protecting group and R 2 represents hydrogen or hydroxyl protecting group, provided that R 1 and R 2 simultaneously represent hydrogen, or in which D is hydroxyl protecting group, (b) esterification hydroxyl group in position 3 compounds (III) or (IV) to obtain compounds of general formula (V) or (VI), in which R 1 , R 2 and D have values given above, and (c) removing hydroxyl protecting groups R 1 or R 2 , or R 1 or R 2 , or the compounds (V) or (VI) to obtain ingenol-3-angelate of formula (I). EFFECT: method allows to produce end product with good output. 25 cl, 11 tbl, 29 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 586 975 C2 (51) МПК C07C 67/08 (2006.01) C07C 67/297 (2006.01) C07C 69/533 (2006.01) C07D 319/08 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2013107386/04, 08.07.2011 (24) Дата начала отсчета срока действия патента: 08.07.2011 Приоритет(ы): (30) Конвенционный приоритет: (43) Дата публикации заявки: 27.08.2014 Бюл. № 24 (73) Патентообладатель(и): ЛЕО ЛЭБОРЕТЕРИЗ ЛИМИТЕД (IE) R U 20.07.2010 US 61/366,018 (72) Автор(ы): ХЕГБЕРГ Томас (DK), ...

ПРОИЗВОДНЫЕ ТАКСАНА Ш, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ

FIELD: organic chemistry. SUBSTANCE: invention relates to new derivatives of taxane-III of the formula (I) where R 1 = is H; R 14 = is H, C 2 -C 9 -alkanoyl nonsubstituted with halogen atom, or R 1 and R 14 taken together are carbonyl or lower alkylidene; R 7 = R 10 is H, tri(lower alkyl)silyl or free C 2 -C 9 -alkalnoyl or that mono-, di- or tri-substituted with halogen atom; R 13 is H, group -COCHOHCH-(C 6 H 5 )--NHCO-C 6 H 5 or -COCHOHCH-(C 6 H 5 )--NHCOOC-(CH 3 ) 3 ; Ac is acetyl. These compounds show antitumor activity. Invention relates to also methods of synthesis of compounds of the formula (I) where R 1 = R 7 = R 10 = R 13 = R 14 - H from plant Taxus Walliehiana above ground parts and methods of synthesis of compounds of the formula (I) with different values of radicals R 1 , R 7 , R 10 , R 13 and R 14 , and pharmaceutical composition based on taxane derivatives of the formula (I). EFFECT: improved method of synthesis. сзуеггс пы Го РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (19) ВИ” 2419 485 ' 13) СЛ 5 МК С 070 305/14, А 61 К 31/335 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 93004623/04, 04.03.1993 (30) Приоритет: 06.03.1992 ПТ М 192 А 000528 (46) Дата публикации: 27.09.1998 (56) Ссылки: ЕР, 0253738, С ОТО 3051/14, 1988. ЕР, 0473326, С 070 305/14, 1992. РСТ, 92 09582, С 07 О 305/14, 1992. (71) Заявитель: Индена С.п.А. (1Т) (72) Изобретатель: Эцо Бомбарделли (1Т), Бруно Габетга (1Т) (73) Патентообладатель: Индена С.п.А. (ТТ) (54) ПРОИЗВОДНЫЕ ТАКСАНА Ш, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ (57) Реферат: Изобретение относится к новым производным таксана !! формулы 1, в которой КЮ - Н К - Н, С>2-Со-алканоил, незамещенный атомом галогена, или К и К 14, взятые вместе, представляют собой карбонил или низший алкилиден; К7= Клд - Н, три(низший алкил)силил или С 2-Сэ-алканоил, незамещенный или моно-, ди-, тризамещенный атомом галогена; Каз - Н, -СОСНОНСН-(СьН5) МНСОСвьН5 или -СОСНОНСН (СьНМНСоОсС(СНз)3-группа; Ас ...

СОЕДИНЕНИЯ И СПОСОБЫ ЛЕЧЕНИЯ PHK-ОПОСРЕДОВАННЫХ ЗАБОЛЕВАНИЙ

ANTIVIRAL TETRACYCLONONANE DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Esterverbindungen, Polymere, Resistzusammensetzungen und Strukturierungsverfahren

A process for the production of compositions containing a substantial amount of dimethanonaphthalene

Dimethanonaphthalene is obtained by reacting cyclopentadiene with bicyclo-[2,2,1]-heptadiene-2,5 in a mole ratio of 1 : 4 to 5: 1, and optionally acetylene, at 275-365 DEG C. and 6-15 kg./cm.2 for 5-15 minutes. In a preferred embodiment this reaction is followed by a further heating for 5-60 minutes at the same or a higher temperature up to 450 DEG C. The mole ratio of acetylene, if present, to cyclopentadiene may be 0.1-3. Trimethanoanthracene may also be formed. Unreacted materials may be separated by distillation and recycled and higher boiling polymers also separated. Hydrogenation of the products yields dimethanodecatin and trimethanoperhydroanthracene, useful as jet fuels. Specification 836,104 is referred to.

Improvements in and relating to pesticides

As active components of pesticides, particularly of insecticides, use is made of addition products of dialkyl or diaryl malonates with decachloro-octahydro - 1,3,4 - metheno - 2H - cyclobuta(cd)pentalen - 2 - one, to which is assigned the cage formula (see Division C2). The addition products are said to have the formula The products may be formulated as liquid compositions or wettable powders with the aid of liquid or solid diluents, a number of which are specified. Examples and experimental results are given.

SORDARIN DERIVATIVES

Sordarin derivatives are antifungal agents useful in the treatment and/or prevention of human and animal fungal infections, as well as in the control of phytopathogenic fungi in crops.

REACTION PRODUCTS OF AN OLEFIN, A NORBORNENE AND A CYCLOPENTADIENE

A product mixture of a norbornene and a tetracyclododecene is prepared in any desired mole ratio in the range of 95/5 to 5/95 which comprises heating an olefin, cyclopentadiene, and a norbornene in the respective mole ratio of 1-20/1-5/1-5, at a temperature of 100 to 400.degree.C, 100 to 5000 psi, and 0.1 to 5 hours of residence time.

Chrysenes for deep blue luminescent applications

This disclosure relates to chrysene compounds with deep blue emission that are useful in electroluminescent applications. It also relates to electronic devices in which the active layer includes such a chrysene compound.

Resist composition for immersion exposure, method of forming resist pattern using the same, and fluorine-containing compound

BISAZO COMPOUNDS

Chrysenes for deep blue luminescent applications

This disclosure relates to chrysene compounds with deep blue emission that are useful in electroluminescent applications. It also relates to electronic devices in which the active layer includes such a chrysene compound.

Synthesis and applications of soluble pentacene precursors and related compounds

The present disclosure relates to methods and systems for synthesis of bridged-hydropentacene, hydroanthracene and hydrotetracene from the precursor compounds pentacene derivatives, tetracene derivatives, and anthracene derivatives. The invention further relates to methods and systems for forming thin films for use in electrically conductive assemblies, such as semiconductors or photovoltaic devices.

Medicament for treatment of non-insulin dependent diabetes mellitus, hypertension and/or metabolic syndrome

A dietary supplement or medicament comprising a substance including the chemical structure of bicyclo [3.2.1]octan or the chemical structure of kaurene. The medicament is useful for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome. The possible substances include steviol, isosteviol or stevioside.

Glaucocalyxin a derivative and preparation method and application thereof

Provided is a glaucocalyxin A derivative, or salt thereof, as represented by the formula (I), a method for preparation of said glaucocalyxin A derivative, and a use for said glaucocalyxin A derivative in preparing pharmaceuticals for fighting autoimmune diseases and tumors, e.g. difficult-to-treat diseases such as systemic lupus erythematosus, psoriasis and triple-negative breast cancer

Low system memory detection

Methods, systems, and computer readable media may be operable to facilitate an anticipation of an execution of a process termination tool. An allocation stall counter may be queried at a certain frequency, and from the query of the allocation stall counter, a number of allocation stall counter increments occurring over a certain duration of time may be determined. If the number of allocation stall counter increments is greater than a threshold, a determination may be made that system memory is running low and that an execution of a process termination tool is imminent. In response to the determination that system memory is running low, a flag indicating that system memory is running low may be set, and one or more programs, in response to reading the flag, may free memory that is not necessary or required for execution.

BIFUNCTIONAL COMPOUND HAVING NORBORNANE SKELETON AND METHOD FOR PRODUCING SAME

The present invention is able to provide a bifunctional compound represented by formula (I). 112-. (canceled)14. The method according to claim 13 , wherein the catalyst having hydrogenation activity comprises at least one element selected from the group consisting of copper claim 13 , chromium claim 13 , iron claim 13 , zinc claim 13 , aluminium claim 13 , nickel claim 13 , cobalt and palladium.16. The method according to claim 15 , comprising performing the hydroformylation reaction using: the rhodium compound in an amount of 0.1 to 60 μmol relative to 1 mol of the monoolefin represented by formula (2); and the organic phosphorous compound in an amount of 300 to 10000 times the molar quantity of the rhodium compound. The present invention relates to a bifunctional compound useful as a paint additive, adhesive, resin raw material or the like and a method for producing the same, and particularly relates to a bifunctional compound having a norbornane skeleton in the molecule and a method for producing the same.It is known that a bifunctional compound having a norbornane skeleton exhibits excellent characteristics when used as an adhesive or resin raw material. As the bifunctional compound having a norbornane skeleton, tricyclodecane dicarbaldehyde and pentacyclopentadecane dicarbaldehyde are known, and several production methods have been reported (Patent Document 1).Patent Documents 2 to 4 describe that tricyclodecane dicarbaldehyde is obtained by hydroformylating dicyclopentadiene in the presence of a rhodium catalyst using a mixed gas of carbon monoxide and hydrogen. Further, Patent Document 5 describes that tricyclodecane dicarbaldehyde or pentacyclopentadecane dicarbaldehyde is obtained by hydroformylating dicyclopentadiene or tricyclopentadiene in the presence of a rhodium catalyst using a mixed gas of carbon monoxide and hydrogen.The tricyclodecane dicarbaldehyde described in Patent Documents 2 to 5 is a compound in which one norbornane and cyclopentane share a ...

POLYESTER RESIN AND PRODUCTION METHOD THEREFOR

A polyester resin according to the present invention comprises a constitutional unit represented by general formula (1): The present invention relates to a polyester resin and a production method therefor.Polyethylene terephthalate (hereinafter sometimes referred to as “PET”) is a polyester resin that is characterized by excellent transparency, mechanical strength, melt stability, solvent resistance, aroma retaining properties, and recyclability, and is widely utilized in film, sheet, hollow containers, and the like. However, it cannot be said that PET has a sufficiently high glass transition temperature, also transparency may be impaired due to its crystallinity when a thick molded, article is obtained, and therefore modification by copolymerization is widely carried out.For example, polyester resins are proposed in which 1,4-cyclohexanedimethanol, tricyclodecanedimethanol, or pentacyclopentadecanedimethanol is used as a copolymerization component for polyesters. Since tricyclodecanedimethanol and pentacyclopentadecanedimethanol have a bulky, rigid skeleton, polyester resins involving these have a high glass transition temperature, the crystallinity is suppressed, and it is thus possible to increase the transparency of a molded article (see, for example, Patent Literatures 1 and 2).On the other hand, among the aliphatic polyesters in which completely no aromatic components are used, polyesters with an alicyclic structure have excellent transparency and water resistance, and thus a large number of methods involving an alicyclic monomer represented by 1,4-cyclohexanedimethanol are proposed. For example, Patent Literature 3 discloses an aliphatic polyester composed of 1,4-cyclohexanedimethanol with 1,4-cyclohexanedicarboxylic acid or the like. Also, for increased heat resistance of aliphatic polyesters, polyesters having a norbornane skeleton are proposed (see, for example, Patent Literatures 4 and 5).The polyester resins described in Patent Literatures 1 and 2 are ...

13-OXIDIZED INGENOL DERIVATIVE AND USE THEREOF

The present invention relates to a derivative of 13-oxidized ingenol, use thereof in the prevention and/or treatment of a disease associated with proliferation or tumor in a subject, or a cosmetic indication, and use thereof in the prevention and/or treatment of a disease responsive to neutrophil oxidative burst, a disease responsive to a release of IL-8 by keratinocyte, or a disease responsive to induction of necrosis. 2. The compound of claim 1 , or a pharmaceutically acceptable salt claim 1 , solvate claim 1 , prodrug claim 1 , metabolite or crystal form thereof claim 1 , wherein Ris selected from the group consisting of hydrogen and M-C(O)— claim 1 , wherein M is selected from the group consisting of linear alkyl and C-Clinear alkenyl.3. The compound of claim 1 , or a pharmaceutically acceptable salt claim 1 , solvate claim 1 , prodrug claim 1 , metabolite or crystal form thereof claim 1 , wherein claim 1 , Ris selected from the group consisting of hydrogen and Q-C(O)— claim 1 , wherein Q is selected from the group consisting of C-Clinear alkyl claim 1 , C-Cbranched alkyl claim 1 , C-Clinear alkenyl claim 1 , C-Cbranched alkenyl claim 1 , 5-6 membered cycloalkyl claim 1 , phenyl claim 1 , 5-6 membered nitrogen-containing aliphatic heterocyclic group claim 1 , 5-6 membered heteroaryl claim 1 , 8-10 membered partially saturated nitrogen-containing fused heterocyclic group claim 1 , and NR′R″ claim 1 , wherein claim 1 , R′ is methyl group claim 1 , R″ is phenyl group optionally substituted with halogen(s); and in the 5-6 membered heteroaryl group claim 1 , the heteroatom is selected from the group consisting of nitrogen and oxygen;{'sub': 1', '5', '4', '5', '3', '5', '3', '5, 'optionally, the C-Clinear alkyl group, C-Cbranched alkyl group, C-Clinear alkenyl group or C-Cbranched alkenyl group is independently substituted with one or more phenyl groups, wherein the phenyl group is optionally substituted with methyl group(s);'}{'sub': 2', '3', '2, 'optionally, the 5-6 ...

FLUORINATING AGENT

An object of the present invention is to provide a novel substance that has a high reactivity as a fluorinating agent, is effectively used in various fluorination reactions, and is safely handled even in air. As the solution for achieving this object, the present invention provides a complex obtained by reacting bromine trifluoride with at least one metal halide selected from the group consisting of halogenated metals and halogenated hydrogen metals in a nonpolar solvent. This complex serves as a fluorinating agent that provides excellent fluorination performance and that is stable in air. 19-. (canceled)10. A method for fluorinating a compound , the method comprising:bringing the compound into contact with a complex consisting of bromine trifluoride and at least one metal halide selected from the group consisting of halogenated metals and halogenated hydrogen metals.11. The method according to claim 10 , wherein the complex exhibits an exothermic decomposition onset temperature in nitrogen of 40° C. or higher.12. The method according to claim 10 , wherein the complex is a reaction product obtained by mixing bromine trifluoride with at least one metal halide selected from the group consisting of halogenated metals and halogenated hydrogen metals claim 10 , in a nonpolar solvent.13. The method according to claim 12 , wherein the reaction product is obtained by reacting 0.5 mol or more of the metal halide claim 12 , per mol of bromine trifluoride.14. The method according to claim 10 , wherein the metal halide is at least one member selected from the group consisting of a halogenated metal represented by the formula: MX claim 10 , wherein M is Mor (M)1/2) claim 10 , Mis an alkali metal claim 10 , and Mis an alkaline earth metal claim 10 , and X is a halogen atom; and a halogenated metal represented by the formula: MHX claim 10 , wherein M and X are as defined above.15. The method according to claim 10 , wherein the metal halide is at least one potassium halide selected ...

Complex and structurally diverse compounds

The invention provides a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp 3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

Method of isolating ingenol

The present invention relates to a new method for isolating ingenol (C 20 H 28 O 5 ) from mixtures of diterpenoid esters and ingenol esters in a single step. Ingenol isolated by means of this method can be used as a precursor for the synthesis of biologically active ingenol derivatives, such as ingenol-3-angelate and ingenol-3-tigliate.

Compound isolated from isodon forrestii var. forrestii and preparation method and applications thereof

A compound of Formula I or pharmaceutically acceptable salt thereof and its preparation method and applications, the new structure of the compound of formula I has not been reported in literature. It is isolated from Isodon forrestii var. forrestii and can be a compound served as Trx1 selective inhibitor. The present invention further discloses a pharmaceutical composition, preparation of the compound of Formula I and its applications in preparing medicines for preventing or treating cancer. Iso A of the present invention has the advantages of low toxicity, high safety and strong pharmacological effect, which suggests a potential prospect in pharmaceutical applications.

Shelf life mass polymerizable polycycloolefin compositions as optical materials

Embodiments in accordance with the present invention encompass compositions encompassing a latent organo-ruthenium compound and a pyridine compound along with one or more monomers which undergo ring open metathesis polymerization (ROMP) when said composition is exposed to suitable actinic radiation to form a substantially transparent film. Surprisingly, the compositions are very stable at ambient conditions to temperatures up to 80° C. for several days and undergo mass polymerization when subject only to actinic radiation. Accordingly, compositions of this invention are useful in various opto-electronic applications, including as 3D printing materials, coatings, encapsulants, fillers, leveling agents, among others.

15-Oxospiramilactone Derivatives, Preparation Method and Uses Thereof

The invention relates to a derivative of 15-oxospiramilacton, particularly to a compound of Formula I or II, or an isomer, a solvate or a pharmaceutically acceptable salt thereof. The invention also relates to a pharmaceutical composition comprising the compound as pharmaceutically active ingredient, a method for preparing the same, and use thereof in manufacture of an anti-tumor agent. The derivative of 15-oxospiramilactone of the invention have an activity against multiple tumor cell lines, and the anti-tumor activity is positively correlated to an activity inhibiting the Wnt signaling pathway.

Ingenol-3-acylates iii and ingenol-3-carbamates

The invention relates to compounds of general formula I wherein R is heteroaryl optionally substituted by R7; or R is heterocycloalkyl or heterocycloalkenyl, optionally substituted by R8; or R is X wherein X is —NR11R12; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use—alone or in combination with one or more other pharmaceutically active compounds—in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.

METHOD FOR PRODUCING BIFUNCTIONAL COMPOUND HAVING NORBORNANE SKELETON

The present invention provides a method for producing a bifunctional compound having a norbornane skeleton, the method comprising a step of hydroformylating a compound having an olefin with carbon monoxide and hydrogen, wherein the molar ratio of the carbon monoxide to the hydrogen during the reaction is 55/45 or more and 95/5 or less in the hydroformylating step. 3. The method of claim 1 , wherein the hydroformylating uses 0.1 to 60 micromoles of a rhodium compound per mole of the compound of formula (2) claim 1 , and 300 to 10000 moles of an organic phosphorus compound per mole of a rhodium atom in the rhodium compound. The present invention relates to a method for producing a bifunctional compound having a norbornane skeleton useful as coating additives, adhesives, starting materials of resin, and the like. Also, the present invention relates to a production method for preventing a monofunctional compound having a norbornane skeleton from being by-produced.It is known that a bifunctional compound having a norbornane skeleton exhibits excellent characteristics when used as adhesives or starting materials of resin. As a method for producing a bifunctional compound having a norbornane skeleton, for example, Patent Literature 1 describes that a bifunctional compound having a norbornane skeleton can be obtained through a hydroformylation reaction of a compound having a corresponding olefin.Patent Literature 1: International Publication No. WO 2015/147242A hydroformylation reaction is performed by reacting a compound having an olefin with an oxo gas, in presence of a catalyst containing rhodium or cobalt. The oxo gas for use as a starting material in the hydroformylation reaction is usually a gas having a controlled molar ratio between carbon monoxide and hydrogen of 50:50, because the hydroformylation reaction is represented by the following reaction formula. In the reaction between the oxo gas and the compound having an olefin, however, a certain amount of byproduct ...

BIFUNCTIONAL COMPOUND HAVING NORBORNANE SKELETON AND METHOD FOR PRODUCING SAME

The present invention is able to provide a bifunctional compound represented by formula (1). 111-. (canceled)13. The process as claimed in claim 12 , wherein Rin formula (3-a) and Rin in formula (3-b) represents H.14. The process as claimed in claim 12 , wherein Rin formula (3-a) and Rin in formula (3-b) represents CH.15. The process as claimed in claim 12 , wherein Rin formula (3-a) and Rin in formula (3-b) represents CH. The present invention relates to a bifunctional compound useful as a paint additive, adhesive, resin raw material or the like and a method for producing the same, and particularly relates to a bifunctional compound having a norbornane skeleton in the molecule and a method for producing the same.It is known that a bifunctional compound having a norbornane skeleton exhibits excellent characteristics when used as an adhesive or resin raw material. As the bifunctional compound having a norbornane skeleton, tricyclodecane dicarbaldehyde and pentacyclopentadecane dicarbaldehyde are known, and several production methods have been reported (Patent Document 1).Patent Documents 2 to 4 describe that tricyclodecane dicarbaldehyde is obtained by hydroformylating dicyclopentadiene in the presence of a rhodium catalyst using a mixed gas of carbon monoxide and hydrogen. Further, Patent Document 5 describes that tricyclodecane dicarbaldehyde or pentacyclopentadecane dicarbaldehyde is obtained by hydroformylating dicyclopentadiene or tricyclopentadiene in the presence of a rhodium catalyst using a mixed gas of carbon monoxide and hydrogen.The tricyclodecane dicarbaldehyde described in Patent Documents 2 to 5 is a compound in which one norbornane and cyclopentane share a plurality of atoms with each other to form the main skeleton as shown in formula (5) below. Further, the pentacyclopentadecane dicarbaldehyde described in Patent Document 5 is a compound in which two norbornanes and cyclopentane share a plurality of atoms with each other to form the main skeleton as ...

Diterpene production in yarrowia

The present invention relates to a method for the production of a diterpene or a glycosylated diterpene, which method comprises: a. fermenting a recombinant microorganism of the genus Yarrowia in a suitable fermentation medium at a temperature of about 29° C. or higher, wherein the microorganism comprises one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity and whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol; and b. recovering the diterpene or glycosylated diterpene.

Method of producing ingenol-3-angelate

The present invention relates to methods of producing ingenol-3-angelate (I) from ingenol (II). Furthermore, the invention relates to intermediates useful for the synthesis of ingenol-3-angelate (I) from ingenol (II) and to methods of producing said intermediates.

BIFUNCTIONAL COMPOUND HAVING NORBORNANE SKELETON AND METHOD FOR PRODUCING SAME

The present invention is able to provide a bifunctional compound represented by formula (1). 212-. (canceled)13. The bifunctional compound according to claim 1 , wherein Rrepresents COOCH.14. The bifunctional compound according to claim 1 , wherein Rrepresents COOCH.15. The bifunctional compound according to claim 1 , wherein Rrepresents COOCH.16. The bifunctional compound according to claim 1 , wherein Rrepresents COOCH.17. The bifunctional compound according to claim 1 , wherein Rrepresents CHO. The present invention relates to a bifunctional compound useful as a paint additive, adhesive, resin raw material or the like and a method for producing the same, and particularly relates to a bifunctional compound having a norbornane skeleton in the molecule and a method for producing the same.It is known that a bifunctional compound having a norbornane skeleton exhibits excellent characteristics when used as an adhesive or resin raw material. As the bifunctional compound having a norbornane skeleton, tricyclodecane dicarbaldehyde and pentacyclopentadecane dicarbaldehyde are known, and several production methods have been reported (Patent Document 1).Patent Documents 2 to 4 describe that tricyclodecane dicarbaldehyde is obtained by hydroformylating dicyclopentadiene in the presence of a rhodium catalyst using a mixed gas of carbon monoxide and hydrogen. Further, Patent Document 5 describes that tricyclodecane dicarbaldehyde or pentacyclopentadecane dicarbaldehyde is obtained by hydroformylating dicyclopentadiene or tricyclopentadiene in the presence of a rhodium catalyst using a mixed gas of carbon monoxide and hydrogen.The tricyclodecane dicarbaldehyde described in Patent Documents 2 to 5 is a compound in which one norbornane and cyclopentane share a plurality of atoms with each other to form the main skeleton as shown in formula (5) below. Further, the pentacyclopentadecane dicarbaldehyde described in Patent Document 5 is a compound in which two norbornanes and ...

HIGH HEAT MONOMERS AND METHODS OF USE THEREOF

High heat monomer compounds, methods for preparing compounds, and compositions derived from the compounds are provided. Also provided are materials and articles derived from the compounds. 2. The compound of claim 1 , wherein the compound has formula (II).3. The compound of claim 1 , wherein the compound has formula (III).4. The compound of claim 1 , wherein the compound has formula (IV).5. The compound of claim 1 , wherein the compound has formula (VI).6. The compound of claim 1 , wherein the compound has formula (VII).7. The compound of claim 1 , wherein the compound has formula (VIII).8. The compound of claim 1 , wherein the compound has formula (IX).10. The compound of claim 1 , wherein the compound has a purity of 97% or greater claim 1 , as determined by high performance liquid chromatography.11. A curable composition comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(i) a compound according to ;'}(ii) optionally a curing promoter; and(iii) optionally an auxiliary co-monomer.12. The curable composition of claim 11 , wherein the curable composition comprising the auxiliary co-monomer; and the auxiliary co-monomer is selected from maleimide resins claim 11 , benzoxazine resins claim 11 , vinylbenzyl ether resins claim 11 , alkene-containing monomers claim 11 , alkyne-containing monomers claim 11 , arylcyclobutene resins claim 11 , perfluorovinyl ether resins claim 11 , or a combination thereof.13. The curable composition of claim 11 , wherein the curable composition comprising the curing promoter; and the curing promoter is an organic peroxide.14. The curable composition of claim 13 , wherein the organic peroxide is selected from cumene hydroperoxide claim 13 , 2 claim 13 ,5-dimethylhexane-2 claim 13 ,5-dihydroperoxide claim 13 , 2 claim 13 ,5-dimethylhexane-2 claim 13 ,5-dihydroperoxide claim 13 , α claim 13 ,α-bis(t-butylperoxy-m-isopropyl)benzene claim 13 , dicumyl peroxide claim 13 , di(trimethylsilyl)peroxide claim 13 , trimethylsilyl ...

Chrysene compounds for blue or green luminescent applications

This invention relates to chrysene compounds that are useful in electroluminescent applications and are capable of blue or green emission. It also relates to electronic devices in which the active layer includes such a chrysene compound.

PROCEDURE FOR MANUFACTURING INGENOL-3 ANGELAT

Electroluminescent device

본 발명은 특히 인광 화합물의 호스트로서 하기 화학식 I의 화합물을 포함하는 전자 소자, 특히 전계발광 소자에 관한 것이다. 호스트는 인광 물질과 함께 기능하여 전계발광 소자의 개선된 효율성, 안정성, 제조가능성 또는 스펙트럼 특징을 제공할 수 있다. [화학식 I] The present invention relates to an electronic device, particularly an electroluminescent device, comprising a compound of the general formula (I) as a host of a phosphorescent compound. The host may function with the phosphorescent material to provide improved efficiency, stability, manufacturability, or spectral characteristics of the electroluminescent device. (I)

신규한 에스테르 화합물

α위치에 불소 원자 또는 불소 원자를 갖는 알킬기가 치환되며 알콕시메틸기를 에스테르 측쇄에 도입한 아크릴산 에스테르는 신규하다. 아크릴산 에스테르로 부터 얻어진 폴리머는 투명성, 산 탈리성 및 기판 밀착성에 있어서 개선되고 리소그라피 미세가공용 화학 증폭 레지스트 조성물을 제제화 하기 위하여 사용된다. 아크릴산 에스테르, 리소그라피, 레지스트 조성물, 화학증폭

Polymerization of bulky norbornene derivatives and polymers obtainable therewith

Reaction products of an olefin, a norbornene and a cyclopentadiene

A product mixture of a norbornene and a tetracyclododecene is prepared in any desired mole ratio in the range of 95/5 to 5/95 which comprises heating an olefin, cyclopentadiene, and a norbornene in the respective mole ratio of 1-20/1-5/1-5, at a temperature of 100° to 400° C., 100 to 5000 psi, and 0.1 to 5 hours of residence time.

Patent JPH0160011B2

2-ETHYL-1,4,5,8-DIMETHANO-1,2,3,4,4a,5,8,8a-OCTAHYDRONAPHTHALENE COMPOSITION FOR POLYMERIZATION AND PROCESS FOR PRODUCING THE SAME

A process for producing a 2-ethyl-1,4,5,8-dimethano-1,2,3,4,4a,5,8,8a-octahydronaphthalene composition in which the total content of two specific cyclopentadiene trimers is 100 to 5,000 ppm, which process comprises reacting cyclopentadiene and/or dicyclopentadiene with 5-ethyl-2-norbornene under specific conditions. By using the composition as a feed material for various kind of polymerization, homogeneous and transparent polymers containing no gel can be obtained.

Plastomers derived from dimethanooctahydronaphthalene and their method of manufacture

THE INVENTION CONCERNS NEW PLASTOMER POLYMERS OBTAINED BY POLYMERISATION OF AT LEAST ONE NEW MONOMER OF THE GROUP OF DIMETHANOOCTAHYDRONAPHTHALENE AND ITS ALKYL DERIVATIVES (OBTAINED BY REACTION OF AN ALIPHATIC OLEFIN WITH CYCLOPENTADIENE) WITH FROM 0 TO 99% OF A COMPOUND OF THE GROUP OF STYRENE, ACENAPHTHYLENE AND CYCLIC OLEFINS, IN THE PRESENCE OF A CATALYST COMPRISING A SALT OF RUTHENIUM, RHODIUM, PALLADIUM, OSMIUM, IRIDIUM, PLATINUM IN ASSOCIATION WITH AN ALCOHOL OR A SALT OF TITANIUM, VANADIUM, ZIRCONIUM, TUNGSTEN, MOLYBDENUM IN ASSOCIATION WITH A COMPOUND HAVING A METAL-HYDROCARBON OR METAL-HYDROCARBON BOND.

Polyester resin and method for producing same

Compound for organic optoelectronic device, organic light emitting diode including the same and display including the organic light emitting diode

유기광전자소자용 화합물, 이를 포함하는 유기발광소자 및 상기 유기발광소자를 포함하는 표시장치에 관한 것으로, 하기 화학식 1로 표시되는 유기광전자소자용 화합물을 제공하여, 우수한 전기화학적 및 열적 안정성으로 수명 특성이 우수하고, 낮은 구동전압에서도 높은 발광효율을 가지는 유기발광소자를 제조할 수 있다. [화학식 1] The present invention relates to a compound for an organic optoelectronic device, an organic light emitting device including the same, and a display device including the organic light emitting device. The present invention provides a compound for an organic optoelectronic device represented by the following Chemical Formula 1 and having excellent electrochemical and thermal stability, And an organic light emitting device having a high luminous efficiency even at a low driving voltage can be manufactured. [Chemical Formula 1]

Electroluminescent device

The present invention relates to an electronic device, especially an electroluminescent devices, comprising a compound of Formula (I), especially as host for phosphorescent compounds. The hosts may function with phosphorescent materials to provide improved efficiency, stability, manufacturability, or spectral characteristics of electroluminescent devices.

Compound for organic optoelectronic device, organic light emitting diode including the same and display including the organic light emitting diode

유기광전자소자용 화합물, 이를 포함하는 유기발광소자 및 상기 유기발광소자를 포함하는 표시장치에 관한 것으로, 하기 화학식 1로 표시되는 유기광전자소자용 화합물을 제공하여, 우수한 전기화학적 및 열적 안정성으로 수명 특성이 우수하고, 낮은 구동전압에서도 높은 발광효율을 가지는 유기발광소자를 제조할 수 있다. [화학식 1] The present invention relates to a compound for an organic optoelectronic device, an organic light emitting device including the same, and a display device including the organic light emitting device. The present invention provides a compound for an organic optoelectronic device represented by the following Chemical Formula 1 and having excellent electrochemical and thermal stability, And an organic light emitting device having a high luminous efficiency even at a low driving voltage can be manufactured. [Chemical Formula 1]

Chrysenes for deep blue luminescent applications

This disclosure relates to chrysene compounds with deep blue emission that are useful in electroluminescent applications. It also relates to electronic devices in which the active layer includes such a chrysene compound.

Materials for electronic devices

Die vorliegende Anmeldung betrifft ein Polymer,enthaltend mindestens eine Struktureinheit einer Formel (I). Das Polymer eignet sich zur Verwendung in einer elektronischen Vorrichtung.

Compounds that can be used in an organic electronic device as active compounds

The invention relates to compounds that can be used in an organic electronic device as an active compound, in particular for use in electronic devices. The invention further relates to a method for producing the compounds according to the invention, and to electronic devices comprising same.

Organic compound and organic electroluminescent device

一种有机化合物，其特征在于，具有如(1)所示的结构： 其中，L 1 、L 2 和L各自独立的为单键、取代或未取代的C 6 ‑C 30 的亚芳基或者取代或未取代的C 3 ‑C 30 的亚杂芳基；Ar 1 和Ar 2 各自独立的为取代或未取代的C 6 ‑C 60 的芳基、取代或未取代的C 9 ‑C 60 的稠环芳基、取代或未取代的C 3 ‑C 60 的杂芳基或者取代或未取代的C 3 ‑C 60 的稠环杂芳基；R 1 ‑R 4 相同或不同，各自独立的为H、氘、卤素、氰基、硝基、羟基、氨基、取代或未取代的C 1 ‑C 30 的烷基、取代或未取代的C 1 ‑C 30 的烷氧基、取代或未取代的C 3 ‑C 30 的环烷基、取代或未取代的C 3 ‑C 12 的杂环烷基、取代或未取代的C 6 ‑C 30 的芳基、取代或未取代的C 9 ‑C 30 的稠环芳基、取代或未取代的C 3 ‑C 30 的杂芳基或者取代或未取代的C 3 ‑C 30 的稠环杂芳基；其中，R 3 和R 4 可相互连接成环；m、n分别独立地选自1至最大可取的整数。

Compound for organic electronic element, organic electronic element usingthe same, and a electronic device thereof

본 발명은 소자의 발광효율, 안정성 및 수명을 향상시킬 수 있는 신규 화합물 및 이를 이용한 유기전기소자, 그 전자 장치를 제공한다. The present invention provides a novel compound capable of improving luminous efficiency, stability and lifetime of a device, an organic electric device using the same, and an electronic device thereof.

Patent JPS6331450B2

Chrysenes for deep blue luminescent applications

Chrysene compounds for blue or green luminescent applications

本发明涉及用于电致发光应用并且能够发射蓝光或者绿光的䓛化合物。本发明还涉及电子器件，其中的活性层包含此类䓛化合物。

Novel Ester Compounds Having Alicyclic Structure and Making Method

본 발명은 하기 화학식 1로 표시되는 에스테르 화합물에 관한 것이다. 본 발명의 에스테르 화합물을 중합함으로써 얻어지는 중합체로 제조된 레지스트 재료는 고에너지선에 감응하고, 기판과의 밀착성, 감도, 해상성, 에칭 내성이 우수하여 전자선 및 원자외선에 의한 미세 가공에 유용하다. 특히, ArF 엑시머 레이저, KrF 엑시머 레이저의 노광 파장에서의 흡수가 작기 때문에 미세하고 나아가 기판에 대하여 수직인 패턴을 쉽게 형성할 수 있으며, 초 LSI 제조용의 미세 패턴 형성 재료로서 적합하다. The present invention relates to an ester compound represented by the following formula (1). The resist material made of the polymer obtained by polymerizing the ester compound of the present invention is sensitive to high energy rays, has excellent adhesion to the substrate, sensitivity, resolution and etching resistance, and is useful for fine processing by electron beams and far ultraviolet rays. In particular, since the absorption at the exposure wavelength of the ArF excimer laser and the KrF excimer laser is small, it is possible to easily form a fine pattern and further perpendicular to the substrate, and is suitable as a fine pattern forming material for ultra LSI production. 식 중, R 1 은 수소 원자 또는 탄소수 1 내지 6의 직쇄상, 분지상 또는 환상의 알킬기를 나타내고, R 2 는 산 불안정기를 나타내며, k는 0 또는 1, m은 0≤m≤5를 만족하는 정수이다. In the formula, R 1 represents a hydrogen atom or a linear, branched or cyclic alkyl group having 1 to 6 carbon atoms, R 2 represents an acid labile group, k represents 0 or 1, and m satisfies 0 ≦ m ≦ 5. Is an integer.

Chrysene for green light emitting applications

Electroluminescent device

The present invention relates to an electronic device, especially an electroluminescent devices, comprising a compound of Formula (I), especially as host for phosphorescent compounds. The hosts may function with phosphorescent materials to provide improved efficiency, stability, manufacturability, or spectral characteristics of electroluminescent devices.

Chrysene derivative and organic electroluminescent device using the same

A chrysene derivative shown by the following formula: wherein R 1 to R 10 and R 21 to R 25 are independently a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 10 carbon atoms, a substituted or unsubstituted cycloalkyl group having 3 to 10 ring carbon atoms, a substituted or unsubstituted alkylsilyl group having 3 to 20 carbon atoms, a substituted or unsubstituted arylsilyl group having 8 to 30 carbon atoms, or a substituted or unsubstituted aryl group having 6 to 20 ring carbon atoms, provided that at least one of R 21 to R 25 is a substituted or unsubstituted fused aromatic ring group having 10 to 20 ring carbon atoms or a substituted or unsubstituted fluorenyl group.

Electroluminescent device

The present invention relates to an electronic device, especially an electroluminescent devices, comprising a compound of Formula (I), especially as host for phosphorescent compounds. The hosts may function with phosphorescent materials to provide improved efficiency, stability, manufacturability, or spectral characteristics of electroluminescent devices.

Bifunctional compound having norbornane skeleton and method for producing same

본 발명에 따르면, 하기 식(1)로 표시되는 이관능성 화합물을 제공할 수 있다. (식 중, R 1 은, COOCH 3 , COOC 2 H 5 , COOC 3 H 7 , COOC 4 H 9 , 또는 CHO를 나타낸다. R 2 는, H, CH 3 또는 C 2 H 5 를 나타낸다.) According to the present invention, it is possible to provide a bifunctional compound represented by the following formula (1). (In the formula, R 1 represents COOCH 3 , COOC 2 H 5 , COOC 3 H 7 , COOC 4 H 9 , or CHO. R 2 represents H, CH 3 or C 2 H 5 .)

Resist composition for immersion exposure, method of forming resist pattern using the same, and fluorine-containing compound

A resist composition for immersion exposure, including a base component (A) that exhibits changed solubility in an alkali developing solution under action of acid, an acid generator component (B) that generates acid upon exposure, and a fluorine-containing compound (C) represented by a general formula (c-1) shown below that is decomposable in an alkali developing solution: wherein R 1 represents an organic group which may contain a polymerizable group, with the proviso that said polymerizable group has a carbon-carbon multiple bond, and the carbon atoms forming the multiple bond are not directly bonded to the carbon atom within the -C(=O)- group in general formula (c-1); and R 2 represents an organic group having a fluorine atom.

Acid Generator, Sulfonic Acid, Sulfonic Acid Derivatives And Radiation-Sensitive Resin Composition

본 발명은 하기 화학식 1i의 구조를 가진 신규한 감방사선성 산발생제를 제공한다. 이 감방사선성 산발생제를 화학 증폭형 감방사선성 수지 조성물에 사용할 경우, 감방사선성 산발생제는 높은 투명성 및 비교적 높은 가연성을 나타내며 인체 축적성에 문제가 없으며, 발생하는 산의 산성도 및 비점이 높고, 레지스트 피막 중에서의 확산 길이가 적당히 짧으며 마스크 패턴 밀도에 대한 의존성이 낮다. The present invention provides a novel radiation-sensitive acid generator having a structure of Formula 1i. When the radiation-sensitive acid generator is used in a chemically amplified radiation-sensitive resin composition, the radiation-sensitive acid generator has high transparency and relatively high flammability and has no problem in human accumulation, and the acidity and boiling point of acid generated High, the diffusion length in the resist film is moderately short, and the dependence on the mask pattern density is low. <화학식 1i> <Formula 1i> 식 중, R은 불소 함유율이 50 중량％ 이하인 1가의 유기기, 니트로, 시아노기 또는 수소 원자를 나타내고, Z 1 및 Z 2 는 서로 독립적으로 불소 원자 또는 탄소수 1 내지 10의 직쇄상 또는 분지상의 퍼플루오로알킬기를 나타낸다. In the formula, R represents a monovalent organic group, nitro, cyano group or hydrogen atom having a fluorine content of 50% by weight or less, and Z 1 and Z 2 are each independently a fluorine atom or a linear or branched carbon atom having 1 to 10 carbon atoms. Perfluoroalkyl group is represented. 산발생제, 감방사선성 수지 조성물, 알칼리 가용성 수지, 술폰산 Acid generator, radiation sensitive resin composition, alkali soluble resin, sulfonic acid

Positive photoresist composition containing alicyclic dissolution inhibitors

폴리머, 광활성제, 및 다음 화학식 (1)로 표현되는 용해 억제제를 포함하는 포지티브 포토레지스트 조성물: A positive photoresist composition comprising a polymer, a photoactive agent, and a dissolution inhibitor represented by the following general formula (1): 상기 화학식 (1)에서 R 1 및 R 2 는 각각 독립적으로 히드록실기, C 1-8 히드록시알킬기, 또는 C 3-8 히드록시시클로알킬기이고; R 3 , R 4 및 R 5 는 각각 독립적으로 수소, C 1-8 히드록시알킬기, C 1-6 카르복실산 또는 C 3-8 카르복실산 에스테르이고; k는 0, 1, 2, 3, 4, 5 또는 6 인 정수이다. 본 발명의 포토레지스트 조성물은 KrF와 ArF 엑시머레이저로부터의 원자외선 (deep UV)에 노출될 때 화학적으로 증폭된 형태의 레지스트로서 유용하다. R 1 and R 2 in the formula (1) are each independently a hydroxyl group, a C 1-8 hydroxyalkyl group, or a C 3-8 hydroxycycloalkyl group; R 3 , R 4 and R 5 are each independently hydrogen, a C 1-8 hydroxyalkyl group, C 1-6 carboxylic acid or C 3-8 carboxylic acid ester; k is an integer equal to 0, 1, 2, 3, 4, 5 or 6. The photoresist compositions of the invention are useful as chemically amplified forms of resist when exposed to deep UV from KrF and ArF excimer lasers. 폴리머, 광활성제, 용해 억제제, 포지티브 포토레지스트, 리소그래피 Polymers, Photoactive Agents, Dissolution Inhibitors, Positive Photoresists, Lithography

Amine based compound and organic light emitting device comprising the same

본 명세서는 아민계 화합물 및 이를 포함하는 유기 발광 소자를 제공한다.

Compound for organic electronic element, organic electronic element usingthe same, and a electronic device thereof

본 발명은 소자의 발광효율, 안정성 및 수명을 향상시킬 수 있는 신규 화합물 및 이를 이용한 유기전기소자, 그 전자 장치를 제공한다.

Amine based compound and organic light emitting device comprising the same

본 명세서는 아민계 화합물 및 이를 포함하는 유기 발광 소자를 제공한다. The present invention provides an amine compound and an organic light emitting device comprising the same.

Salt and photoresist composition containing the same

A salt represented by the formula (I-CC): wherein Q 1 and Q 2 each independently represent a fluorine atom etc., X 1 represents a single bond etc., Y 1 represents a C1-C36 aliphatic hydrocarbon group etc., A 1 and A 2 independently each represents a C1-C20 aliphatic hydrocarbon group etc., Ar 1 represents a (m 4 +1)-valent C6-C20 aromatic hydrocarbon group which can have one or more substituents, B 1 represents a single bond etc., B 2 represents a group capable of being eliminated by the action of an acid, m 1 and m 2 independently each represents an integer of 0 to 2, m 3 represents an integer of 1 to 3, with the proviso that m 1 plus m 2 plus m 3 equals 3, and m 4 represents an integer of 1 to 3, and a photoresist composition comprising the salt represented by the formula (I-CC) and a resin comprising a structural unit having an acid-labile group and being insoluble or poorly soluble in an aqueous alkali solution but becoming soluble in an aqueous alkali solution by the action of an acid.

Salt and photoresist composition containing the same

A salt represented by the formula (I-CC): wherein Q 1 and Q 2 each independently represent a fluorine atom etc., X 1 represents a single bond etc., Y 1 represents a C1-C36 aliphatic hydrocarbon group etc., A 1 and A 2 independently each represents a C1-C20 aliphatic hydrocarbon group etc., Ar 1 represents a (m 4 +1)-valent C6-C20 aromatic hydrocarbon group which can have one or more substituents, B 1 represents a single bond etc., B 2 represents a group capable of being eliminated by the action of an acid, m 1 and m 2 independently each represents an integer of 0 to 2, m 3 represents an integer of 1 to 3, with the proviso that m 1 plus m 2 plus m 3 equals 3, and m 4 represents an integer of 1 to 3, and a photoresist composition comprising the salt represented by the formula (I-CC) and a resin comprising a structural unit having an acid-labile group and being insoluble or poorly soluble in an aqueous alkali solution but becoming soluble in an aqueous alkali solution by the action of an acid.

Novel Ester Compounds, Polymers, Resist Materials and Process for Forming Pattern

하기 화학식 1a로 표시되는 에스테르 화합물을 구성 단위로서 함유하는 중량평균 분자량 1,000 내지 500,000의 고분자 화합물. A polymer compound having a weight average molecular weight of 1,000 to 500,000 containing an ester compound represented by the following formula (1a) as a structural unit. 식 중, In the formula, R 1 은 수소 원자, 메틸기 또는 CH 2 CO 2 R 14 를 나타내고, R 1 represents a hydrogen atom, a methyl group or CH 2 CO 2 R 14 , R 2 는 수소 원자, 메틸기 또는 CO 2 R 14 를 나타내고, R 2 represents a hydrogen atom, a methyl group or CO 2 R 14 , R 3 은 탄소수 1 내지 8의 직쇄상, 분지상 또는 환상의 알킬기 또는 탄소수 6 내지 20의 치환될 수 있는 아릴기를 나타내고, R 3 represents a linear, branched or cyclic alkyl group having 1 to 8 carbon atoms or an aryl group which may be substituted with 6 to 20 carbon atoms, R 4 내지 R 13 은 각각 독립적으로 수소 원자 또는 탄소수 1 내지 15의 헤테로 원자를 포함할 수 있는 1가의 탄화수소기를 나타내고, 서로 환을 형성할 수 있으며, 그 경우에는 탄소수 1 내지 15의 헤테로 원자를 포함할 수 있는 2가의 탄화수소기를 나타내고, R 4 to R 13 each independently represent a hydrogen atom or a monovalent hydrocarbon group which may include a hetero atom having 1 to 15 carbon atoms, and may form a ring with each other, in which case include a hetero atom having 1 to 15 carbon atoms Represents a divalent hydrocarbon group, 또한, R 4 내지 R 13 은 인접하는 탄소에 결합하는 것 끼리 아무것도 개재하지 않고 결합하며, 2중 결합을 형성할 수 있고, In addition, R 4 to R 13 may be bonded to each other without bonding between adjacent carbons, may form a double bond, R 14 는 탄소수 1 내지 15의 직쇄상, 분지상 또는 환상의 알킬기를 나타낸다. R 14 represents a linear, branched or cyclic alkyl group having 1 to 15 carbon atoms. 본 발명의 고분자 화합물을 기재 수지로한 레지스트 재료는 고에너지선에 감응하고, 감도, 해상성, 엣칭 내성이 우수하기 때문에, 전자선이나 원자외선에 의한 미세가공에 유용하다. ArF 엑시머 레이저, KrF 엑시머 레이저의 노광 파장에서의 흡수가 작기 때문에, 미세하고 또한 기판에 대하여 수직인 패턴을 용이하게 형성할 수 있다. Since the resist material using the polymer compound of the present invention as a base resin is sensitive to high energy rays and excellent in sensitivity, resolution, and etching resistance, it is useful for microfabrication by electron beam or far ultraviolet rays. Since the absorption at the exposure wavelength of the ArF excimer laser ...

Salt for acid generator and chemically amplified resist composition

Functional norbornanyl ester derivatives, polymers and process for preparing same

本发明涉及一种新的功能性降冰片酯衍生物和/或聚合物组成,该功能性降冰片酯衍生物和/或聚合物可以方便地通过由相应的二烯烃和二烯亲和物所得到的狄尔斯‑阿尔德反应加成物与羧酸进行反应来制备。本发明主要涉及一种生产环状化工原料的新方法,这种环状化工原料可用于制造涂料，油墨，粘合剂，增塑剂,热塑性或热固性塑料和功能性聚合物。

Heterocyclic compound and organic light emitting device comprising same

본 명세서는 화학식 1로 표시되는 헤테로고리 화합물 및 이를 포함하는 유기 발광 소자에 관한 것이다.

Novel tertiary alcohol compounds having alicyclic structure

Tertiary alcohol compounds of formula (1) are novel wherein R 1 and R 2 are C1-10 alkyl groups which may have halogen substituents, or R 1 and R 2 may form an aliphatic hydrocarbon ring, Y and Z are a single bond or a divalent C1-10 organic group, and k=0 or 1. Using the tertiary alcohol compounds as a monomer, polymers are obtained. A resist composition comprising the polymer as a base resin is sensitive to high-energy radiation and has excellent sensitivity, resolution, etching resistance and substrate adhesion.

Chrysene compounds for blue or green luminescent applications

This invention relates to chrysene compounds that are useful in electroluminescent applications and are capable of blue or green emission. It also relates to electronic devices in which the active layer includes such a chrysene compound.

Electroluminescence device

Electroluminescent device

Plastomers derived from dimethanooctahydronaphthalene and their manufacturing process

Traction fluids, method of using these fluids and traction drives thus obtained

Ingenol-3-acylates i

The invention relates to compounds of general formula (I) wherein R is (C1-C7)alkyl, (C2-C7)alkenyl or (C2-C7)alkynyl; wherein R is substituted with R1; and pharmaceutically acceptable salts, hydrates, or solvates thereof, for use -alone or in combination with one or more other pharmaceutically active compounds- in therapy, for preventing, treating or ameliorating diseases or conditions responsive to stimulation of neutrophil oxidative burst, responsive to stimulation of keratinocyte IL-8 release or responsive to induction of necrosis.

NEW NORBORNYLANE AND DIMETHANODECAHYDRONAPHTYLANE DERIVATIVES

La présente invention a pour objet des dérivés I du norbornylane et du diméthanodécahydronaphtylane de formule (CF DESSIN DANS BOPI) dans laquelle : - R est H quand n est égal à 1 - ou R est CH2 =C(R1 )-C(O)- avec R1 représentant H ou CH3 et n égal à 0 ou à 1. L'invention a également pour objet des procédés de préparation des dérivés I et leurs applications.

Lube base oil and lubricating oil composition

본 발명은, 화학식 I 내지 VI으로 표시되는 구조를 기본 골격으로 하는 탄화수소 화합물을 1종 이상 포함하고, -40℃에서의 점도가 40 Pa·s 이하이며, 점도 지수가 80 이상인 윤활유 기유로서, 고온 트랙션 계수, 저온 유동성 및 점도 지수를 높은 차원으로 만족하는 윤활유 기유 및 윤활유 조성물을 제공한다. 화학식 I (상기 식에서, p는 1 내지 10의 정수를 나타내며, 단, 화학식 I 및 II에 있어서, p는 1이 아니다.) The present invention is a lubricant base oil containing at least one hydrocarbon compound having a structure represented by the formulas (I) to (VI) as a basic skeleton, having a viscosity at −40 ° C. of 40 Pa · s or less, and a viscosity index of 80 or more. Provided are lubricating oil base oils and lubricating oil compositions which satisfy the traction coefficient, low temperature fluidity and viscosity index in high dimensions. Formula I (Wherein p represents an integer of 1 to 10, except that in formulas I and II, p is not 1)

Method for preparing norbornene structure compound

A method for preparing a norbornene structure compound comprises hydrogenating a compound represented by the formula of ##STR1## wherein l, m and n are integers of 0≦l≦3, 0≦m≦8 and 1≦n≦3, respectively, and each of R 1 to R 6 is a hydrogen atom or a hydrocarbon residue having 1 to 3 carbon atoms with or without R 6 forming a ring with R 4 or R 5 , in the presence of a Ziegler type catalyst containing in combination a compound of a transition metal of Groups IV to VI of the periodic table and an organometallic compound of Groups I to III of the periodic table, to thereby convert the compound of the formula (1) into a compound represented by the following formula of ##STR2## wherein l, m and n are the same as above.

Electronic device using organic thin film, and electronic apparatus containing same

The present invention provides a high-performance, highly homogeneous, highly stable electronic device by forming an extremely uniform interface between an insulator and an organic semiconductor, as well as an electronic apparatus using the same. The present invention relates to an electronic device which contains, as a component, an organic thin film in which skeletal structures of a positive three-pronged shape of triptycene are interdigitated, and by adding a first molecule extending out of one plane of a two-dimensional molecular structure of the triptycene skeletal structure, a geometric two-dimensional arrangement is formed regularly. The invention also relates to an electronic apparatus and the like which contains the electronic device in the interior of the electronic apparatus.

Resist composition for immersion exposure, method of forming resist pattern using the same, and fluorine-containing compound

A resist composition for immersion exposure, including a base component that exhibits changed solubility in an alkali developing solution under action of acid, an acid generator component that generates acid upon exposure, and a fluorine-containing compound represented by a general formula (c-1) that is decomposable in an alkali developing solution: wherein R 1 represents an organic group which may contain a polymerizable group, with the proviso that said polymerizable group has a carbon-carbon multiple bond, and the carbon atoms forming the multiple bond are not directly bonded to the carbon atom within the —C(═O)— group in general formula (c-1); and R 2 represents an organic group having a fluorine atom.

A substance for the use in a dietary supplementation or for the preparation of a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome

A substance including the chemical structures of bicyclo[3.2.1]octan or the chemical structures of kaurene for the use in a dietary supplementation or as a constituent in a medicament for the treatment of non-insulin dependent diabetes mellitus, hypertension and/or the metabolic syndrome. The unique chemical structures of bicyclo[3.2.1]octan alone or in a kaurene structure provides the substances, such as e.g. steviol, isosteviol and stevioside with the capability of enhancing or potentiating the secretion of insulin in a plasma glucose dependent manner. The substances including these unique chemical structures also have the capability of reducing the glucagon concentration in the blood and/or lowering the blood pressure thereby providing a self-regulatory treatment system for non-insulin dependent diabetes mellitus and/or hypertension. In a combination drug which also comprise a soy protein, and/or soy fiber and/or at least one isoflavone these substances act synergistically and such combination drugs are highly useful both prophylacticly or directly in the treatment of e.g. the metabolic syndrome and obesity and has due to the self-regulatory effect a widespread applicability as a dietary supplementation.

compound, use of a compound, methods of prevention, treatment, amelioration or prophylaxis of physiological disorders or diseases, and treatment or amelioration of cosmetic indications, and, pharmaceutical composition

Pyrene derivative, light emitting element, and light emitting device

It is an object of the present invention to provide a pyrene derivative that is unlikely to crystallize and is superior in quality in the case of forming a film. In addition, it is an object of the present invention to provide a light-emitting element from which stable light emission can be obtained for a long stretch of time by using the pyrene derivative. A pyrene derivative represented by the general formula (1) is synthesized. By using vacuum deposition to deposit this material, a light-emitting element from which stable light emission can be obtained efficiently for a long stretch of time can be obtained.

Ether, polymer, resist composition and patterning process

An ether compound of formula (1) is provided wherein R 1 is H or C 1-6 alkyl, R 2 is C 1-6 alkyl, R 3 is H, C 1-15 acyl or C 1-15 alkoxycarbonyl which may be substituted with halogen atoms, k is 0 or 1, m is from 0 to 3, and n is from 3 to 6. The ether compound is polymerized to form a polymer having improved reactivity, robustness and substrate adhesion. A resist composition comprising the polymer as a base resin is sensitive to high-energy radiation, has excellent sensitivity, resolution, and etching resistance, and lends itself to micropatterning with electron beams or deep-UV

Substance for use in dietary supplementation or for prepn. of medicament for treating non-insulin dependent diabetes mellitus, Hypertension and/or metabolic syndrome

用于食品补充剂中或者作为组分用于治疗非胰岛素依赖性糖尿病、高血压和/或代谢综合征的药物中的包含二环[3.2.1]辛烷化学结构或贝壳杉烯的物质。单独的或者在贝壳杉烯结构中的独特二环[3.2.1]辛烷化学结构提供了能够以依赖于血浆葡萄糖的方式增强或促进胰岛素分泌的物质例如甜叶菊醇、异甜叶菊醇和卡哈苡苷。包含这些独特化学结构的物质还能够降低血液胰高血糖素浓度和/或降低血压，并由此给非胰岛素依赖性糖尿病和/或高血压提供自我调控的治疗系统。在还含有大豆蛋白、和/或大豆纤维和/或至少一种异黄酮的复方药物中，这些物质协同作用，并且这样的复方药物可高度用于预防或直接治疗例如代谢综合征和肥胖，并且由于自我调控作用，能广泛地用作食品补充剂。

Process for the preparation of norbornene and substituted norbornene derivatives

Polyimide precursor, polyimide, polyimide film, substrate, and tetracarboxylic acid dianhydride used for producing polyimide

【課題】透明性、折り曲げ耐性、高耐熱性、低線熱膨張係数などの優れた特性を有するポリイミド及びその前駆体を提供する。【解決手段】テトラカルボン酸成分に由来する構造が化学式（Ａ−３）又は（Ａ−４）のいずれかで表される構造である繰り返し単位を少なくとも１種含むポリイミド前駆体、及びポリイミド。【選択図】なし

Borneol derivatives affecting tubulin polymerization and depolymerization

The invention relates to borneol derivatives of the general formula (I) in which R1 is C(O)-CH(OR6)-CH(NHR7)-R8, R2 is hydrogen, -OH, C1-C10-Alkyl, C1C10-alkoxy, -OC(O)R9b, -OP(O)(OH)2 or R2 and R3 are together an oxygen atom, R4 is hydrogen, C1-C10-alkyl, -(CH2)n-OR11a, R5 is hydrogen, C1-C10-alkyl, (CH2)p-OR11b, or R4 and R5 together are an oxygen atom, a =CHR10 group, n is 0 to 8, p is 1 to 8, R7 is -C(O)R12, -SO2R12, -C(O)NHR9d, -C(O)NR9dR9e, (formula), R8 is aryl, R9a-e and R12 are the same or different and represent C1-C10-akyl, C4-C8-cycloalkyl, aryl, C7-C16-aralkyl, R10 is hydrogen, C1-C10-alkyl, -(CH2)s-OR14, s is 1 to 8, R6, R11a,b and R14 are the same or different and represent hydrogen, C1-C10-alkyl, aryl, C7-C16 aralkyl, SO2R9c, P(O)(OH)2, R13 and R15a,b are the same or different and represent hydrogen, C1C10-alkyl, aryl, C7-C16-aralkyl, X1 and X2 are the same or different and mean X, X may be hydrogen, halogen, -OH, -NO2, -N3, -CN, -NR15aR15b, -NHSO2R15a, CO2R14, C1-C10-alkyl, C1-C10-alkoxy, C1-C10-acyloxy, C1-C10-acyl and, if R15 is hydrogen, their salts with physiologically tolerable bases, and .alpha.-, .beta.- or .gamma.-cyclodextrin clathrates, and the compounds of the general formula (I) encapsulated with liposomes.

Chrysene compounds for deep blue luminescent applications

This disclosure relates to chrysene compounds with deep blue emission that are useful in electroluminescent applications. It also relates to electronic devices in which the active layer includes such a chrysene compound.

Benzophenanthrene derivative and organic electroluminescent device employing the same

A fused aromatic ring derivative shown by the following formula (1): wherein R a and R b are independently a hydrogen atom or a substituent, p is an integer of 1 to 8 and q is an integer of 1 to 11, when p is 2 or more, plural R a s may be independently the same or different and adjacent R a s may form a ring, when q is 2 or more, plural R b s may be independently the same or different, L 1 is a single bond, or a substituted or unsubstituted divalent linking group, and Ar 1 is a substituted or unsubstituted aryl group having 6 to 50 ring carbon atoms or a substituted or unsubstituted heteroaryl group having 5 to 50 ring atoms, provided that the substituent of L 1 , the substituent of Ar 1 , R a and R b contain no substituted or unsubstituted amino group.

Chrysene compounds for blue or green luminescence applications

Lumpy polymerizable polycycloolefin composition as an optical material with improved shelf life

본 발명에 따른 실시형태는 1종 이상의 단량체와 함께 잠재 오르가노-루테늄 화합물, 피리딘 화합물을 함유하는 조성물을 포함하며, 해당 조성물은 적합한 화학방사선에 노광하면 개환 복분해중합(ROMP)을 일으켜 실질적으로 투명한 필름을 형성한다. 해당 조성물은 대기 조건 하에 최대 80℃의 온도에서도 며칠간 안정성을 유지하며, 화학방사선에 노광했을 때만 덩이중합을 일으킨다. 따라서, 본 발명의 조성물은, 광전자 분야에서의 각종 용도 중에서도 특히 3D 프린팅 재료, 코팅, 캡슐화제, 충전재, 레벨링제에 유용하다.

Electronic device using organic thin film, and electronic apparatus containing same

The present invention provides a high-performance, highly homogeneous, highly stable electronic device by forming an extremely uniform interface between an insulator and an organic semiconductor, as well as an electronic apparatus using the same. The present invention relates to an electronic device which contains, as a component, an organic thin film in which a geometric two-dimensional arrangement is formed regularly by interdigitating skeletal structures of a positive three-pronged shape of triptycene and by adding a first molecule extending out of one plane of a two-dimensional molecular structure of the triptycene skeletal structure. The invention also relates to an electronic apparatus and the like which contains the electronic device in the interior of the electronic apparatus.

Bifunctional compound having norbornane backbone, and method for producing same

The bifunctional compound according to the present invention is represented by the following formula (1): wherein R 1 is a hydrogen atom, CH 3 , or C 2 H 5 ; R 2 and R 3 are each independently a hydrogen atom or CH 3 ; and X is a hydrogen atom or a hydrocarbon group having no more than 4 carbon atoms and optionally containing a hydroxyl group.

Pyrene derivative, organic light-emitting medium, and organic electroluminescent element containing pyrene derivative or organic light- emitting medium

An organic light-emitting medium including a pyrene derivative represented by the following formula (1) and a phenyl-substituted anthracene derivative represented by the following formula (2): wherein Ar 1 to Ar 4 are independently a substituted or unsubstituted aryl group having 6 to 30 ring carbon atoms or a substituted or unsubstituted heteroaryl group having 5 to 20 ring atoms.

Diterpene production in yarrowia

Bifunctional compound with norbornane skeleton and manufacturing method thereof

由本發明，能夠提供一種下述式(1)所表示之二官能性化合物。 (式中，R 1 表示COOCH 3 、COOC 2 H 5 、COOC 3 H 7 、COOC 4 H 9 或CHO，R 2 表示H、CH 3 或C 2 H 5 )。

Crystalline ingenol mebutate

The present invention relates to a novel crystalline form of ingenol mebutate, methods of preparation thereof, and to its use. More specifically, the invention relates to the conversion of amorphous ingenol mebutate (ingenol-3-angelate, PEP005) to a crystalline form, which was characterized by single crystal X-Ray crystallography (XRC), attenuated total reflectance Fourier transform infrared (FTIR-ATR) spectroscopy and Differential Scanning Calorimetry (DSC).

Method to make steviol glycoside isomers

Steviol glycoside isomers are provided having the formula: wherein R 1 may be hydrogen, 1-β-D-glucopyranosyl, or 2-(1-β-D-glucopyranosyl)-1-β-D-glucopyranosyl, and R 2 may be hydrogen, 1-β-D-glucopyranosyl, 2-(1-β-D-glucopyranosyl)-1-β-D-glucopyranosyl, 2,3-bis(1-β-D-glucopyranosyl)-1-β-D-glucopyranosyl, 2-(1-α-L-rhamnopyranosyl)-1-β-D-glucopyranosyl, 2-(1-α-L-rhamnopyranosyl)-3-(1-β-D-glucopyranosyl)-1-β-D-glucopyranosyl, or 2-(1-β-D-xylopyranosyl)-3-(1-β-D-glucopyranosyl)-1-β-D-glucopyranosyl. Methods for making steviol glycoside isomers are also disclosed. These compounds may be present in food and beverage products as non-nutritive sweeteners.

Acid generators, sulfonic acids, sulfonyl halides, and radiation-sensitive resin compositions

The invention provides novel acid generators which are unproblematic in combustibility and accumulation inside the human body and can generate acids having high acidities and high boiling points and exhibiting properly short diffusion lengths in resist coating films and which permit the formation of resist patterns excellent smoothness with little dependence on the denseness of a mask pattern; sulfonic acids generated from the acid generators; sulfonyl halides useful as raw material in the synthesis of the acid generators; and radiation-sensitive resin compositions containing the acid generators. The acid generators have structures represented by the general formula (I): (I) [wherein R1 is a monovalent substituent such as alkoxycarbonyl, alkylsulfonyl, or alkoxysulfonyl; R2 to R4 are each hydrogen or alkyl; k is an integer of 0 or above; and n is an integer of 0 to 5]. Among the radiation-sensitive resin compositions, a positive one contains a resin having acid-dissociable groups in addition to the above acid generator, while a negative one contains an alkali-soluble resin and a crosslinking agent in addition to the acid generator.