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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 3731. Отображено 100.
21-06-2012 дата публикации

Phosphorous derivatives as chemokine receptor modulators

Номер: US20120157413A1
Автор: Haiqing Yuan, John E. Donello, Michael E. Garst, Richard I. Beard, Veena Viswanath, Xiaoxia Liu
Принадлежит: Allergan Inc

The present invention relates to novel phosphorous derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

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Номер записи: 1
25-04-2013 дата публикации

Compounds, Compositions, And Methods For Reducing Or Eliminating Bitter Taste

Номер: US20130101684A1
Автор: Brown Peter H., Gunnet Joseph, Hayashi David, Jones William P., Langer Jessica, Lavery Daniel, Leland Jane V., Shekdar Kambiz, SLADE Louise
Принадлежит: CHROMOCELL CORPORATION

The present invention provides edible compositions comprising a compound of the present invention, food products comprising such edible compositions and methods of preparing such food products. The present invention also provides methods of reducing the amount of NaCl in a food product, methods of reducing the sodium intake in a diet, and methods of reducing bitter taste in a food product. 710.-. (canceled)1355.-. (canceled)5661112. The composition of any one of - claims 1 , or claims 1 , further comprising a bitter tastant.576111256. The composition of any one of - claims 1 , claims 1 , or claims 1 , wherein the composition further comprises one or more components selected from the group consisting of: NaCl claims 1 , sodium lactate and sugar.58611125657. The composition of any one of - claims 1 , claims 1 , claims 1 , or claims 1 , wherein the composition is found in a food product or a consumer product.5961112. The composition of any one of - claims 1 , or claims 1 , wherein the composition further comprises a pharmaceutically active ingredient claims 1 , and optionally claims 1 , a bitter tastant.60. The composition of claim 59 , wherein the pharmaceutically active ingredient is bitter.61. The composition of or claim 59 , wherein the pharmaceutically active ingredient or bitter tastant is a potassium salt.62. The composition of any one of claim 59 , or claim 59 , wherein the bitter tastant is a potassium salt claim 59 , and wherein the potassium salt is potassium chloride or potassium lactate.6361112. A method of use of the composition of any one of - claims 1 , or claims 1 , wherein the method comprises:(a) providing a comestibly acceptable carrier; and{'claim-ref': {'@idref': 'CLM-00001', 'claims 1'}, 'b': '8', '(b) adding to the comestibly acceptable carrier, a composition as described in any of - or combinations thereof.'}64. The method of claim 63 , wherein the method further comprises adding a bitter tastant to the comestibly acceptable carrier.65. The ...

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Номер записи: 2
16-05-2013 дата публикации

ALLOSTERIC BINDING COMPOUNDS

Номер: US20130123326A1
Автор: Jensen Henrik Helligsø, Neubauer Henrik Amtoft, Wiborg Ove Kjaer
Принадлежит:

The present invention relates to allosteric binding compounds of formula (I), especially for the treatment of CNS disorders, together with pharmaceutical compositions and methods of treatment including these compounds. 2. The method according to claim 1 , comprising administering the compound of formula (I) wherein A is an aryl ring.35.-. (canceled)6. The method according to claim 1 , comprising administering the compound of formula (I) claim 1 , wherein B is a 6-membered cycloalkyl claim 1 , aryl claim 1 , or heteroaryl ring claim 1 , which ring together with A forms an annulated ring system.78.-. (canceled)9. The method according to claim 1 , comprising administering the compound of formula (I) claim 1 , wherein B is a 5-membered heteroaryl ring claim 1 , which ring together with A forms an annulated ring system.1011.-. (canceled)14. (canceled)15. The method according to claim 1 , comprising administering the compound of formula (I) claim 1 , wherein Lis selected from the group consisting of —O— claim 1 , —NH— claim 1 , and —NR—.16. The method according to claim 15 , wherein Ris Calkyl.17. The method according to claim 16 , wherein Ris selected from the group consisting of methyl claim 16 , ethyl claim 16 , propyl claim 16 , isopropyl claim 16 , butyl claim 16 , iso-butyl claim 16 , sec-butyl claim 16 , and tert-butyl.1821.-. (canceled)22. The method according to claim 1 , comprising administering the compound of formula (I) claim 1 , wherein Ris selected from the group consisting of Calkyl claim 1 , Calkoxy claim 1 , Calkenyl claim 1 , Calkynyl claim 1 , and —NH—Calkyl claim 1 , where any of these optionally is substituted with one or more substituents.23. (canceled)24. The method according to claim 22 , wherein Ris Calkyl claim 22 , wherein the alkyl optionally is substituted with one or more substituents.2527.-. (canceled)29. The method according to claim 28 , wherein Lis selected from the group consisting of —O— and —S—.3038.-. (canceled)39. The method ...

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Номер записи: 3
25-07-2013 дата публикации

SULFUR DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS

Номер: US20130190338A1
Автор: Beard Richard L., Donello John E., Garst Michael E., Liu Xiaoxia, Viswanath Veena, Yuan Haiqing
Принадлежит: ALLERGAN, INC.

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors. 2. A compound according to claim 1 , wherein:{'sup': '5', 'Ris S.'}3. A compound according to claim 1 , wherein:{'sup': '5', 'Ris —S(O)—.'}4. A compound according to claim 1 , wherein:{'sup': '5', 'sub': '2', 'Ris —S(O)—.'}5. A compound according to claim 1 , wherein:{'sup': '1', 'Ris H;'}{'sup': '2', 'sub': 1-6', '3-8', '3-8, 'Ris substituted or unsubstituted Calkyl, substituted or unsubstituted Ccycloalkyl or substituted or unsubstituted Ccycloalkenyl;'}{'sup': '5', 'sub': '2', 'Ris —S—, —S(O)—, or —S(O)—;'}{'sup': '6', 'Ris optionally substituted 1-benzofuran;'}{'sup': '17', 'sub': '1-6', 'Ris H, substituted or unsubstituted Calkyl or halogen;'}{'sup': '18', 'sub': '1-6', 'Ris H, substituted or unsubstituted Calkyl or halogen;'}{'sup': '7', 'sub': 1-6', '1-6', '3-8, 'Ris H, halogen, CN, —OCalkyl, substituted or unsubstituted Calkyl or substituted or unsubstituted Ccycloalkyl; and'}{'sup': '8', 'sub': '1-6', 'Ris H, substituted or unsubstituted Calkyl, CN or halogen.'}6. A compound according to claim 5 , wherein:{'sup': '1', 'Ris H;'}{'sup': '2', 'sub': '1-6', 'Ris substituted or unsubstituted Calkyl;'}{'sup': '5', 'sub': '2', 'Ris —S—, —S(O)—, or —S(O)—;'}{'sup': '6', 'Ris optionally substituted 1-benzofuran;'}{'sup': '17', 'Ris H;'}{'sup': '18', 'Ris H;'}{'sup': '7', 'sub': '1-6', 'Ris H, halogen or Calkyl; and'}{'sup': '8', 'Ris H or CN.'}7. A compound according to claim 6 , wherein:{'sup': '1', 'Ris H;'}{'sup': '2', 'Ris methyl propionate, methyl-2-benzoic acid, methyl-2-methylbenzoate, methyl-3-methylphenylacetamide, methyl-3-methylphenylsulfonamide, methyl acetic acid, methyl-2-methylphenylcarboxylate or propionic acid;'}{'sup': '5', 'sub': '2', 'Ris —S(O)—, S or —S(O)—;'}{'sup': '6', 'Ris optionally substituted 1-benzofuran;'}{'sup': '7', 'Ris chlorine, ...

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Номер записи: 4
15-08-2013 дата публикации

Preparation of methionine or selenomethionine from homoserine via a carbamate intermediate

Номер: US20130211078A1
Автор: Dayna Turner, James Peterson, Kevin Trankler, Richard Vonder Embse, Steve Lorbert, Tracy Rode
Принадлежит: Novus International Inc

Provided herein are processes for the production of methionine or selenomethionine from homoserine. In particular, the processes proceed via the production of carbamate intermediates.

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Номер записи: 5
05-09-2013 дата публикации

ROS-Activated Compounds as Selective Anti-Cancer Therapeutics

Номер: US20130230542A1
Автор: Bell-Horwath Tiffany, LI Guorui, Merino Edward J., Mulloy James C.
Принадлежит:

Provided are compounds according to the following Formula I: 2. The compound according to claim 1 , wherein said alkyl claim 1 , aryl claim 1 , and aralkyl substitutions are selected from the group consisting of alkoxyl claim 1 , halo claim 1 , OH claim 1 , CN claim 1 , carboxyl claim 1 , carboxyl ester claim 1 , and substituted or unsubstituted alkyl.3. The compound according to claim 1 , wherein Ris H or alkyl when Ris aryl or aralkyl claim 1 , and wherein Ris H or alkyl when Ris aryl or aralkyl.4. The compound according to claim 1 , wherein Rand Rare each independently selected from the group consisting of H claim 1 , substituted or unsubstituted C-Calkyl claim 1 , and substituted or unsubstituted phenyl; and Ris OH.5. The compound according to claim 1 , wherein the cancer is associated with production of elevated reactive oxygen species.6. The compound according to claim 5 , wherein the cancer is selected from the group consisting of leukemia claim 5 , renal cancer claim 5 , and cancers of the central nervous system.7. The compound according to claim 6 , wherein the leukemia is selected from the group consisting of acute myeloid leukemia claim 6 , acute lymphoblastic leukemia claim 6 , plasmacytoma claim 6 , myeloma claim 6 , myelogenous leukemia claim 6 , acute lymphocytic leukemia claim 6 , acute promyelocytic leukemia claim 6 , and multiple myeloma.9. A method of reducing proliferative capacity in a cell claim 1 , the method comprising contacting the cell with an effective amount of a compound according to .10. The method according to claim 9 , wherein the cell is a mammalian cell.11. The method according to claim 10 , wherein the cell is a cancer cell.12. A method of treating a cancer associated with elevated ROS comprising administering to a subject in need thereof an effective amount of a compound according to .13. The method according to claim 12 , wherein the subject is a mammal.14. The method according to claim 13 , wherein the cancer is selected from ...

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Номер записи: 6
31-10-2013 дата публикации

Substituted 2-[2-(phenyl) ethylamino] alkaneamide derivatives and their use as sodium and/or calcium channel modulators

Номер: US20130289122A1
Автор: Alessandra Restivo, Cibele Sabido-David, Elena Colombo, Emanuela Izzo, Piero Melloni, Simona Francisconi
Принадлежит: Newron Pharmaceuticals SpA

Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them are useful as sodium and/or calcium channel modulators for preventing, alleviating and curing pathologies wherein the above mechanisms play a pathological role. The compounds may be particularly useful for the prevention, alleviation, and curing of, for example, neurological, cognitive, psychiatric, inflammatory, urogenital and gastrointestinal diseases.

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Номер записи: 7
21-11-2013 дата публикации

ISOPRENYL COMPOUNDS AND METHODS THEREOF

Номер: US20130310559A1
Автор: Chen Jinglong, Chen Shuyi, Gordon Joel, Lee Seung-Yub, Perez Eduardo, Rapole Keshava, Stock Jeffry B., Stock Maxwell, Voronkov Michael
Принадлежит: SIGNUM BIOSCIENCES, INC.

Among other things, the present invention provides novel isoprenyl compounds capable of effectively modulating inflammatory responses and pharmaceutical, cosmetic, cosmeceutical and topical compositions comprising these isoprenyl compounds. Anti-inflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with inflammation. Proinflammatory compounds of the present invention are useful in treating or preventing diseases or conditions associated with suppression of inflammatory responses. Thus, the present invention also provides methods useful in the treatment or prevention of diseases or conditions associated with inflammation as well as methods useful in the treatment or prevention of diseases or conditions associated with suppression of inflammatory responses. 2. (canceled)3. The compound according to claim 1 , wherein L is selected from a bivalent claim 1 , branched or unbranched claim 1 , saturated or unsaturated claim 1 , Chydrocarbon chain wherein one or more methylene units of L is independently replaced by —NH— claim 1 , —C(O)— claim 1 , —CH═CH— claim 1 , C-Ccycloalkylene claim 1 , C-Cheterocycloalkylene claim 1 , 8-10-membered bicyclic heterocyclic moiety claim 1 , an optionally substituted arylene and optionally substituted heteroarylene claim 1 , and wherein L is optionally substituted by one or more groups selected from halogen claim 1 , substituted or unsubstituted C-Calkyl claim 1 , and —NHC(O)CH.5. The compound according to claim 1 , wherein L is selected from a bivalent claim 1 , branched or unbranched claim 1 , saturated or unsaturated claim 1 , Chydrocarbon chain wherein one or more methylene units of L is independently replaced by —NH— claim 1 , —C(O)— claim 1 , —C(═CH)— claim 1 , —CH═CH— claim 1 , C-Ccycloalkylene claim 1 , 8-10-membered bicyclic heterocyclic moiety claim 1 , an optionally substituted arylene and optionally substituted heteroarylene claim 1 , and wherein L is optionally ...

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Номер записи: 8
05-12-2013 дата публикации

Industrial Methods for Producing Arylsulfur Pentafluorides

Номер: US20130324765A1
Автор: Norimichi Saito, Teruo Umemoto
Принадлежит: UBE Industries Ltd

Industrial methods for producing arylsulfur pentafluorides are disclosed. Methods include reacting arylsulfur halotetrafluoride with hydrogen fluoride in the absence or presence of one or more additives selected from a group of fluoride salts, non-fluoride salts, and unsaturated organic compounds to form arylsulfur pentafluorides.

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Номер записи: 9
12-12-2013 дата публикации

Lipids for therapeutic agent delivery formulations

Номер: US20130330401A1
Автор: John A. Gaudette, Joseph E. Payne, Jun Zhang, Lei Yu, Mohammad Ahmadian, Neda SAFARZADEH, Priya Karmali, Richard P. Witte, Victor Knopov, Violetta Akopian, Wenbin Ying, Zheng Hou
Принадлежит: Nitto Denko Corp

The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.

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Номер записи: 10
30-01-2014 дата публикации

CHROMENE COMPOUND

Номер: US20140030529A1
Автор: Izumi Shinobu, Momoda Junji, Takahashi Toshiaki, Takenaka Junji, Teranishi Kazuhiro
Принадлежит: TOKUYAMA CORPORATION

A chromene compound which develops a color of a neutral tint and has high color optical density, high fading speed and excellent durability and a photochromic curable composition comprising the chromene compound and polymerizable monomers. 3. The chromene compound according to claim 1 , wherein in the above formula (2) claim 1 , Rand Rform an aliphatic hydrocarbon ring together with the 13-position carbon atom bonded thereto claim 1 , and the aliphatic hydrocarbon ring has 4 to 20 ring member carbon atoms and may have at least one substituent selected from the group consisting of alkyl group claim 1 , haloalkyl group claim 1 , cycloalkyl group claim 1 , alkoxy group claim 1 , amino group claim 1 , aralkyl group claim 1 , aryl group and halogen atom.4. The chromene compound according to claim 1 , wherein the ratio (A/A) of the color optical density (A: value of λ) of an absorption peak having a maximum absorption wavelength at 430 to 530 nm to the color optical density (A: value of λ) of an absorption peak having a maximum absorption wavelength at 550 to 650 nm is 0.80 to 2.00.5. A photochromic curable composition comprising the chromene compound of and a polymerizable monomer.6. A photochromic optical article having a polymer molded product comprising the chromene compound of dispersed therein as a constituent member.7. An optical article having an optical substrate all or part of at least one surface of which is covered with a polymer film comprising the chromene compound of dispersed therein as a constituent member.9. The chromene compound according to claim 2 , wherein in the above formula (2) claim 2 , Rand Rform an aliphatic hydrocarbon ring together with the 13-position carbon atom bonded thereto claim 2 , and the aliphatic hydrocarbon ring has 4 to 20 ring member carbon atoms and may have at least one substituent selected from the group consisting of alkyl group claim 2 , haloalkyl group claim 2 , cycloalkyl group claim 2 , alkoxy group claim 2 , amino group ...

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Номер записи: 11
20-02-2014 дата публикации

Process to purify dialkyl sulfides

Номер: US20140051891A1
Автор: Elizabeth Burkhardt, Kevin Neigh
Принадлежит: BASF SE

The invention relates to new processes to prepare low odor dialkyl sulfides, the low odor dialkyl sulfides obtainable by these processes and to methods of using these low odor dialkyl sulfides. Moreover, the invention relates to a process to prepare dialkyl sulfide borane complexes of high purity, the dialkyl sulfide borane complexes obtainable by this process and to a process for enantioselective reductions employing these dialkyl sulfide borane complexes of high purity as reducing agent.

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Номер записи: 12
06-03-2014 дата публикации

Method For The Preparation of Poly(Disulfide) Polymers and Gels

Номер: US20140066589A1
Автор: Puskas Judit E., Rosenthall Emily Q.
Принадлежит: THE UNIVERSITY OF AKRON

High molecular weight disulfide polymers are synthesized in aqueous media by exposing dithiol compounds to a mild oxidizing environment in the presence of a tertiary amine catalyst. The unique oxidizing system polymerizes monomers through the formation of sulfur-sulfur bonds between dithiol compounds. The same oxidizing system may be used to make disulfide-crosslinked gels from compounds containing multiple thiol groups. The oxidizing system is comprised of oxygen at atmospheric concentration and dilute hydrogen peroxide. A filler such as carbon black may be incorporated into the polymer or cross-linked gel during polymerization. A polydisulfide polymer is provided having a weight average molecular weight of greater than about 100,000 g/mol and a polydispersity index of about 2 or less. A tetrathiol composition results from a reaction of a diacrylate with a trithiol. The tetrathiol composition may be subjected to an oxidizing environment with a tertiary amine catalyst to provide a polytetrathiol polymer network. 1. A method for the synthesis of poly(disulfide) polymers , the method comprising:providing a dithiol composition, andsubjecting the dithiol composition to an oxidizing environment, in an aqueous solution and in the presence of a tertiary amine catalyst and an additional thiol-containing compound, to provide a crosslinked poly(disulfide) polymer network.2. The method of claim 1 , wherein the dithiol composition comprises at least one dithiol compound selected from the group consisting of aliphatic dithiols and alkoxy dithiols.3. The method of claim 2 , wherein the dithiol composition is a C-Ccompound.4. The method of claim 2 , wherein the dithiol composition is selected from the group consisting of ethanedithiol claim 2 , 2 claim 2 ,2′-[ethane-1 claim 2 ,2diylbis(oxy)]diethanethiol claim 2 , α claim 2 ,ω-thiol functionalized tetraethylene glycol claim 2 , α claim 2 ,ω-thiol functionalized poly(isobutylene) claim 2 , α claim 2 ,ω-thiol functionalized poly( ...

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Номер записи: 13
04-01-2018 дата публикации

COMPOUND COMPRISING AROMATIC RING, POLYMER COMPRISING SAME, AND POLYELECTROLYTE MEMBRANE USING SAME

Номер: US20180006320A1
Автор: Han Joong Jin, Jang Yong Jin, JUNG Sehee, KANG Esder, KIM Youngjea, RYU Hyun Woog, YU Yunah
Принадлежит: LG CHEM, LTD.

The present specification relates to a compound comprising an aromatic ring, a polymer comprising the same, a polyelectrolyte membrane comprising the same, a membrane-electrode assembly comprising the polyelectrolyte membrane, a fuel cell comprising the membrane-electrode assembly, and a redox flow battery comprising the polyelectrolyte membrane. 2. The compound of claim 1 , wherein R1 and R5 are a halogen group claim 1 , and R2 to R4 are hydrogen.3. The compound of claim 1 , wherein R2 and R5 are a halogen group claim 1 , and R1 claim 1 , R3 claim 1 , and R4 are hydrogen.4. The compound of claim 1 , wherein R3 and R5 are a halogen group claim 1 , and R1 claim 1 , R2 claim 1 , and R4 are hydrogen.5. The compound of claim 1 , wherein R2 and R4 are a halogen group or a hydroxy group claim 1 , and R1 claim 1 , R3 claim 1 , and R5 are hydrogen.6. The compound of claim 1 , wherein at least one of R7 to R9 is —SOH or —SOM claim 1 , the others are hydrogen claim 1 , and the definition of M is the same as that in Chemical Formula 1.8. A polymer comprising a monomer derived from the compound of .10. A polyelectrolyte membrane comprising the polymer of .11. The polyelectrolyte membrane of claim 10 , wherein the polyelectrolyte membrane has an ion exchange capacity (IEC) value of 0.01 mmol/g to 7 mmol/g.12. The polyelectrolyte membrane of claim 10 , wherein the polymer has a weight average molecular weight of 500 or more and 5 claim 10 ,000 claim 10 ,000 or less (g/mol).13. The polyelectrolyte membrane of claim 10 , wherein the polyelectrolyte membrane has a thickness of 1 μm or more and 500 μm or less.14. The polyelectrolyte membrane of claim 10 , wherein the polyelectrolyte membrane has ion conductivity of 0.01 S/cm or more and 0.5 S/cm or less.15. A membrane-electrode assembly comprising:an anode;a cathode; and{'claim-ref': {'@idref': 'CLM-00010', 'claim 10'}, 'the polyelectrolyte membrane of disposed between the anode and the cathode.'}16. A polyelectrolyte-type fuel cell ...

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Номер записи: 14
11-01-2018 дата публикации

Process for the preparation of a polyunsaturated ketone compound

Номер: US20180009745A1
Автор: Inger-Reidun AUKRUST, Marcel Sanderberg
Принадлежит: Avexxin AS

A process for the preparation of a polyunsaturated thiol comprising: (1) reacting a polyunsaturated alcohol in the presence of a compound of formula R 2 —SO 2 Hal wherein R 2 is a C 1-20 hydrocarbyl group, such an C 1-10 alkyl group, to form a polyunsaturated sulphonyl ester; (2) converting the polyunsaturated sulphonyl ester to a polyunsaturated thioester by reacting with an anion of formula − SC(═O)R 4 wherein R 4 is a C 1-20 hydrocarbyl group; (3) converting the polyunsaturated thioester to form a polyunsaturated thiol optionally in the presence of an antioxidant, e.g. using a metal carbonate. (4) reacting said polyunsaturated thiol with a compound (LG)R 3 COX wherein X is an electron withdrawing group and R 3 is an alkylene group carrying a leaving group (LG), such as LG-CH 2 — forming where X is an electron withdrawing group and LG is a leaving group; optionally in the presence of an antioxidant, so as to form a polyunsaturated ketone compound.

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Номер записи: 15
09-01-2020 дата публикации

Cytotoxic Chemotherapy-Based Predictive Assays for Acute Myeloid Leukemia

Номер: US20200010910A1
Автор: Brian Jonas, Chong-Xian Pan, George D. Cimino, Kenneth W. Turteltaub, Maike ZIMMERMANN, Michael A. Malfatti, Paul Henderson, Ralph W. DE VERE WHITE, Tiffany Scharadin
Принадлежит: Accelerated Medical Diagnostics Inc, Lawrence Livermore National Security LLC, UNIVERSITY OF CALIFORNIA, US Department of Veterans Affairs VA

The invention relates to methods, systems and kits for determining therapeutic effectiveness or toxicity of cancer-treating compounds that incorporate into or bind to DNA. In particular, the invention is directed to methods, systems and kits for predicting a patient's treatment outcome after administration of a microdose of therapeutic composition to the patient or a sample from the patient. The methods provides physicians with a diagnostic tool to segregate cancer patients into differential populations that have a higher or lower chance of responding to a particular therapeutic treatment.

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Номер записи: 16
14-01-2021 дата публикации

LINKER OF BIOPROBES

Номер: US20210011012A1
Автор: CHEN YU-CHE, LI CHING-WEN
Принадлежит:

A linker of bioprobes, suitable for immobilizing a bioprobe on a chip substrate of a sensor, includes SH—(CH)n-NH2, SH—(CH)n-COOH, SH—(CH)n-SH, (OH)m-(CH)n-COOH or (OH)m-(CH)n-NH2, having a carbon number of 6 or more, m and n being integers greater than 1. When an average surface roughness (Ra) of the chip substrate is greater than 250 nm, coverage of the linker on the chip substrate is 40%-80%. A further linker of bioprobes, includes SH—(CH)n-NH2, SH—(CH)n-COOH, SH—(CH)n-SH, (OH)m-(CH)n-COOH or (OH)m-(CH)n-NH2, having a carbon number of less than 6, m and n being integers greater than 1. When an average surface roughness (Ra) of the chip substrate is less than 250 nm, coverage of the linker on the chip substrate is 65%-100%. The optimal carbon chain length of the linker and the coverage are realized for substrates of various roughnesses, and grasping ability of an electrochemical sensor chip for a detected object are enhanced. 1. A linker of bioprobes , suitable for immobilizing a bioprobe on a chip substrate of a sensor , comprising:SH—(CH)n-NH2, SH—(CH)n-COOH, SH—(CH)n-SH, (OH)m-(CH)n-COOH or (OH)m-(CH)n-NH2, having a carbon number of 6 or more, m and n being integers greater than 1,wherein when an average surface roughness (Ra) of the chip substrate is greater than 250 nm, a coverage of the linker on the chip substrate is in a range of 40% to 80%.2. The linker of bioprobes according to claim 1 , wherein a material of the chip substrate of the sensor is silicon claim 1 , glass claim 1 , graphene claim 1 , gold claim 1 , platinum or polymers.3. The linker of bioprobes according to claim 1 , wherein the chip substrate is subjected to surface treatment according to a proportion of 1 part of 98 wt % sulfuric acid and 3 parts of 33 wt % hydrogen peroxide claim 1 , and a specific roughness is obtained by different treatment time.4. The linker of bioprobes according to claim 1 , further comprising: soaking the chip substrate into a solution of a linker dissolved in 99.8 ...

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Номер записи: 17
17-01-2019 дата публикации

Dental Materials Based On Low-Viscosity Radically Polymerizable Monomers With A High Refractive Index

Номер: US20190015301A1
Автор: Fässler Pascal, FISCHER Urs Karl, MOSZNER Norbert
Принадлежит:

Radically polymerizable, difunctional phenylene sulfide according to Formula I 3. The dental material according to claim 1 , wherein the variables have the following meanings:{'sup': 1', '2, 'R, Rindependently of each other in each case are H or Br,'}{'sup': '3', 'sub': 2', '4, 'Ris dispensed with or is a C-Calkylene radical,'}{'sup': '4', 'sub': 1', '3, 'Ris dispensed with or is a C-Calkylene radical,'}{'sup': '5', 'Ris H,'}a, b, c, d in each case are 0, ande is 1.4. The dental material according to claim 1 , wherein the difunctional phenylene sulfide of Formula I has a viscosity of ≤3 Pa·s claim 1 , measured using a capillary viscometer at a temperature of 23° C.5. The dental material according to claim 4 , wherein the viscosity is in the range of 5 to 2 claim 4 ,000 mPas or 10 to 1 claim 4 ,000 mPa·s claim 4 , measured using a capillary viscometer at a temperature of 23° C.6. The dental material according to claim 1 , wherein the difunctional phenylene sulfide of Formula I has a refractive index of more than 1.57 claim 1 , measured at 20° C. with the light of the yellow Na D line (λ=589 nm).7. The dental material according to claim 6 , wherein the refractive index is in the range of from 1.575 to 1.75 or from 1.58 to 1.72 claim 6 , measured at 20° C. with the light of the yellow Na D line (λ=589 nm).8. The dental material according to claim 1 , which additionally contains at least one initiator for the radical polymerization claim 1 , wherein the initiator comprises a photoinitiator.9. The dental material according to claim 1 , which additionally contains at least one further radically polymerizable monomer claim 1 , wherein the at least one further radically polymerizable monomer comprises at least one mono- or multifunctional (meth)acrylate.10. The dental material according to claim 9 , wherein the at least one mono- or multifunctional (meth)acrylate comprises Bis-GMA claim 9 , UDMA claim 9 , TMX-UDMA claim 9 , DMA claim 9 , TEGDMA claim 9 , CMP-1E claim 9 , ...

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Номер записи: 18
18-01-2018 дата публикации

Processes for the preparation of pesticidal compounds

Номер: US20180016238A1
Автор: Belgin CANTURK, Beth Lorsbach, Carl Deamicis, Elisabeth J. KANE, Gary Roth, Gregory Whiteker, Joseck M. Muhuhi, Kaitlyn Gray, Qiang Yang, Thomas Clark, Yu Zhang
Принадлежит: DOW AGROSCIENCES LLC

The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds.

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Номер записи: 19
18-01-2018 дата публикации

COLD-TOLERANT SEALANTS AND COMPONENTS THEREOF

Номер: US20180016480A1
Автор: Capel Matthew, DeMoss Susan E., Zook Jonathan D.
Принадлежит:

Polythioether polymers, sealants containing polythioether polymers, and compounds useful as stabilizing monomers in the manufacture of polythioether polymers are provided. In many embodiments the polymers and sealants demonstrate reduced risk of spoilage that may be caused by low temperature storage of the polymer or uncured sealant. Compounds useful as stabilizing monomers include compounds according to formula I: CH═CR—CHR—S—R—S—CHR—CR═CH[I] wherein R, R, Rand Rare independently selected from —H, —CHor —CH, and wherein Ris selected from divalent groups comprising 2-12 carbon atoms, 0-5 ether oxygen atoms and 0-5 thioether sulfur atoms, which may be straight, branched or cyclic. 1. A compound according to formula I:{'br': None, 'sub': 2', '2, 'sup': 1', '2', '3', '4', '5, 'CH═CR—CHR—S—R—S—CHR—CR═CH\u2003\u2003[I]'}{'sup': 1', '2', '4', '5, 'sub': 3', '2', '5, 'wherein R, R, Rand Rare independently selected from —H, —CHor —CH, and'}{'sup': '3', 'wherein Ris selected from divalent groups comprising 2-12 carbon atoms, 0-5 ether oxygen atoms and 0-5 thioether sulfur atoms, which may be straight, branched or cyclic.'}2. The compound according to wherein Rand Rare the same and are selected from —H and —CHand wherein Rand Rare the same and are selected from —H and —CH.3. The compound according to wherein Rand Rare —CHand Rand Rare —H.4. The compound according to wherein Ris a divalent group according to formula II:{'br': None, 'sub': 2', 'n', 'm', '2', 'n, '—((CH)—X)—(CH)—\u2003\u2003[II]'}wherein m is 0-5,wherein each n is independently selected from 2-6, andwherein each X is independently selected from O or S.5. A polythioether polymer which is a copolymer of one or more compounds according to with one or more polythiols.6. A polythioether polymer which is a copolymer of one or more compounds according to with one or more polythiols and one or more polyepoxides.7. The polythioether polymer according to wherein the polythiol is a dithiol according to formula VI:{'br': ...

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Номер записи: 20
21-01-2021 дата публикации

ANTICONVULSANT COMPOUNDS

Номер: US20210017116A1
Автор: Durst Tony, Poulter Michael
Принадлежит:

The present application relates to compounds and methods for reducing the severity of convulsant activity or epileptic seizures, or for the treatment of chronic or acute pain. 132-. (canceled)341. The compound of claim , wherein R=R=CH , or a pharmaceutically acceptable salt thereof.352. The compound of claim , wherein Ris:H;{'sub': 5', '5', '3', '2', '5', '3', '2', '3, 'C(O)R, wherein Ris H, CH, CH, CH(CH), CHCHCN, or aryl;'}{'sup': '−', 'sub': 6', '6', '2', '6', '5', '2, 'C(O)—O, or C(O)—O—R, wherein Ris H, a straight or branched C1 to C6 alkyl, CHCH, or CH(CH)n, and wherein n is an integer from 2 to 5;'}{'sub': 2', '6', '7', '8', '7', '8', '2', '6', '5', '7', '8', '2, 'C(O)NH, C(O)NHRor C(O)NRRwherein Rand Rindependently =C1 to C6 alkyl (straight chain or branched), CHCH, aryl, or Rand Rtogether =(CH)m, and wherein m is an integer from 3 to 5; or'}{'sub': 3', '2', '6', '5, 'OH, OCH, or OCHCH,'}or a pharmaceutically acceptable salt thereof.371. A compound of claim , wherein R=H and R=aryl.396. The compound of claim , wherein R=R=CH , or a pharmaceutically acceptable salt thereof.407. The compound of claim , wherein Ris{'sub': 2', '2', '6', '5', '3', '6', '5', '3', '2', '3', '2', '4', '9', '6', '5, 'a straight C5 to C6 alkyl, branched C3 to C6 alkyl, or CH(CH)n, wherein n is an integer from 3 to 5; CHSCH; CH═CHC(O)CH; CH═CHC(O)CH; CH═CHC(O)—O—CH; CH═CHC(O)—O—CH; CH═CHC(O)—O—CH(CH); CH═CHC(O)—O—CH; or CH═CHC(O)—O—CH, or'}a pharmaceutically acceptable salt thereof. This application is a Continuation Application of U.S. patent application Ser. No. 16/723,630 filed Dec. 20, 2019 which is a Divisional Application of U.S. patent application Ser. No. 15/866,924 filed Jan. 1, 2018, U.S. Pat. No. 10,556,853 issued Feb. 11, 2020 which claims priority from provisional application No. 62/444,474 filed Jan. 10, 2017, the entire contents of each are hereby incorporated by reference herein.The present invention relates to compounds with anti-convulsant and pain activity. These ...

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Номер записи: 21
21-01-2021 дата публикации

Zwitterionic polymer, method for producing same and protein stabilizer containing zwitterionic polymer

Номер: US20210017309A1
Автор: Hideharu Mori, Ryutaro Imamura
Принадлежит: NOF Corp, Yamagata University NUC

Provided is a zwitterionic polymer that has a zwitterion that includes an effect of improving the stability of proteins. This zwitterionic polymer is a polymeric protein stabilizer that exhibits a protein stabilizing effect even at a small addition amount of addition, and at the same time has an antioxidant capability. Also provided is a method for producing this zwitterionic polymer. This problem is solved by a zwitterionic polymer containing a repeating unit represented by formula (1) and having a number-average molecular weight of 1,000 to 1,000,000. On formula (1), R 1 and R 2 are each independently selected from a hydrogen atom; linear, branched or cyclic alkyl groups having 1 to 6 carbons; aromatic groups having 6 to 20 carbons; or alkylene groups having 1 to 6 carbons and formed by linking R 1 to R 2 . R 3 represents a hydrogen atom or a methyl group).

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Номер записи: 22
28-01-2016 дата публикации

Compositions and Products for Infectious or Inflammatory Diseases or Conditions

Номер: US20160022713A1
Автор: Huiru Wang
Принадлежит: Huiru Wang

Composition and methods for treating infectious and inflammatory diseases using saccharide based products and therapies. Products can be implemented as a nutritional supplement, a food, a feed, a food additive, a feed additive, a therapeutic product, a rehydration salt, or a rehydration solution. The present disclosure relates generally to the fields of compositions and products containing the compositions, and the use of the compositions or the products for preventing and/or treating infectious or inflammatory diseases or conditions in particular gastrointestinal and respiratory diseases (diarrhea and influenza infections) or inflammatory.

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Номер записи: 23
22-01-2015 дата публикации

Compounds and Methods for Use in Detecting Gabapentin

Номер: US20150024456A1
Автор: Helms Michael Kevin, Moon Byung Sook, Orozco Alejandro A., Valdez Johnny Jose
Принадлежит:

Compounds and methods for use in detecting gabapentin in a sample suspected of containing gabapentin are disclosed. Gabapentin derivatives are used to produce gabapentin conjugates. A gabapentin-immunogenic carrier conjugate may be used as an immunogen for the preparation of an anti-gabapentin antibody. A gabapentin-detectable label may be used in a signal producing system in gabapentin assays. 2. The compound of claim 1 , wherein said linker comprises 0 to 40 carbon atoms and 0-6 heteroatoms.3. The compound of claim 2 , wherein W is a lower alkyl and said linker is selected from the group consisting of{'sub': 2', 'n, '—(CH)C(O)—,'}{'sub': 2', 'n, '—C(O)(CH)—,'}{'sub': 2', 'n, '—C(O)(CH)NH—C(O)—,'}{'sub': 2', 'm', '2', 'n, '—C(O)(CH)NH—C(O)(CH)—,'}{'sub': 2', 'n', '2, '—(CH)SCHC(O)—,'}{'sub': 2', 'm', '2', '2', 'n, '—(CH)SCHC(O)(CH)—,'}{'sub': 2', 'm', '2', 'n, '—(CH)C(O)NH(CH)—,'}{'sub': 2', 'n, '—(CH)NH—C(O)—,'}{'sub': 2', 'm', '2', 'n, '—(CH)NH—C(O)(CH)—,'}{'sub': 2', 'n, '—C(O)—(CH)—, and'}{'sub': 2', 'n, '—(CH)—;'}wherein m, n, o, and p are independently selected from an integer from 0 to 10.4. The compound of claim 2 , wherein W is a carbonyl and said linker is selected from the group consisting of{'sub': 2', 'n, '—(CH)C(O)—,'}{'sub': 2', 'n', '2, '—(CH)SCHC(O)—,'}{'sub': 2', 'm', '2', '2', 'n, '—(CH)SCHC(O)(CH)—,'}{'sub': 2', 'm', '2', 'n, '—(CH)C(O)NH(CH)—,'}{'sub': 2', 'n, '—(CH)NH—C(O)—,'}{'sub': 2', 'm', '2', 'n, '—(CH)NH—C(O)(CH)—, and'}{'sub': 2', 'n, '—(CH)—;'}wherein m, n, o, and p are independently selected from an integer from 0 to 10.5. The compound of claim 1 , wherein W is a lower alkyl group and the lower alkyl group is a methyl group.6. The compound of claim 1 , wherein said reactive functional group is selected from the group consisting of halogen claim 1 , OH claim 1 , SH claim 1 , NH claim 1 , O-lower alkyl claim 1 , epoxy claim 1 , S-acyl claim 1 , carboxyl claim 1 , maleimidyl claim 1 , haloacetamide claim 1 , hydroxysuccinimidyl claim 1 , ...

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Номер записи: 24
24-01-2019 дата публикации

COMPOUND HAVING ENHANCING ACTIVITY FOR GLUCAGON-LIKE PEPTIDE-1 RECEPTOR ACTIONS

Номер: US20190022039A1
Автор: FUJII Tomohiro, KITAHARA Yoshiro, Kitajima Seiji, Ohsumi Koji
Принадлежит: AJINOMOTO CO., INC.

Compounds represented by formula (I): 2. The compound or salt according to claim 1 , wherein{'sub': '6-14', 'A is a Caryl group or a 5- or 6-membered monocyclic aromatic heterocyclic group, each of which is optionally further substituted,'}L is a bond or a methylene group,Q is an oxygen atom,{'sup': 4', '5, 'sub': '1-6', 'Rand Rare the same or different and are each independently a hydrogen atom or an optionally substituted Calkyl group, and'}n is 1 or 2.3. The compound or salt according to claim 1 , wherein{'sub': 1-6', '1-6', '1-6', '1-3', '1-6', '1-6', '1-6', '1-3, 'A is a phenyl group optionally further substituted by the same or different 1 to 5 substituents selected from the group consisting of a halogen atom, a hydroxy group, a carboxy group, a sulfanyl group, an optionally substituted Calkyl group, an optionally substituted Calkoxy group, an optionally substituted amino group, a Calkylthio group optionally substituted by a halogen atom, and a Calkylenedioxy group, or a pyridyl group optionally further substituted by the same or different 1 to 4 substituents selected from the group consisting of a halogen atom, a hydroxy group, a carboxy group, a sulfanyl group, an optionally substituted Calkyl group, an optionally substituted Calkoxy group, an optionally substituted amino group, a 4- to 7-membered monocyclic non-aromatic heterocyclic group, a Calkylthio group optionally substituted by a halogen atom, and a Calkylenedioxy group,'}{'sub': 1-6', '1-6', '1-6', '1-3, 'B is a benzene ring optionally further substituted by the same or different 1 to 4 substituents selected from the group consisting of a halogen atom, a hydroxy group, a sulfanyl group, an optionally substituted Calkyl group, an optionally substituted Calkoxy group, an optionally substituted amino group, a Calkylthio group optionally substituted by a halogen atom, a Calkylenedioxy group, and a 4- to 7-membered monocyclic non-aromatic heterocyclic group,'}L is a bond or a methylene group,{'sup': '1', ...

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Номер записи: 25
17-02-2022 дата публикации

PEG LIPIDS AND USES THEREOF

Номер: US20220047518A1
Автор: Benenato Kerry, Hennessy Edward J.
Принадлежит: Moderna TX, Inc.

The present disclosure in part provides compounds (i.e., PEG lipids) which are useful in pharmaceutical compositions, cosmetic compositions, and drug delivery systems, e.g, for use in lipid nanoparticle (LNP) formulations. The present disclosure also provides LNP formulations comprising PEG lipids described herein, and methods of using the same. For example, the LNPs provided herein are useful for the delivery of an agent (e.g, therapeutic agent) to a subject. The PEG lipids and LNPs provided herein, in certain embodiments, exhibit increased PEG shedding compared to existing PEG lipids and LNP formulations. 30. The LNP of any one of the preceding claims , wherein Lis L.32. The LNP of any one of the preceding claims , wherein Yis —O— , —NR— , or —S—.33. The LNP of any one of the preceding claims , wherein Ris hydrogen.34. The LNP of any one of the preceding claims , wherein Ris optionally substituted Calkyl.35. The LNP of any one of the preceding claims , wherein Ris unsubstituted Calkyl.36. The LNP of any one of the preceding claims , wherein m is 12 , 13 , 14 , or 15.37. The LNP of any one of the preceding claims , wherein s is 12 , 13 , 14 , 15 , 16 , 17 , or 18.38. The LNP of any one of the preceding claims , wherein Ris hydrogen or methyl.39. The LNP of any one of the preceding claims , wherein r is an integer from 35-55 , inclusive.40. The LNP of any one of the preceding claims , wherein r is an integer from 40-50 , inclusive.41. The LNP of any one of the preceding claims , wherein the LNP comprises about 0.15-15% of the PEG lipids.42. The LNP of any one of the preceding claims , wherein the LNP comprises about 1-2% of the PEG lipids.43. The LNP of any one of the preceding claims , wherein the LNP comprises about 1.5% of the PEG lipids.44. The LNP of any one of the preceding claims , further comprising an ionizable amino lipid.51. The LNP of claim any one of - , wherein the ionizable amino lipid is present in a molar ratio of about 25-65% with respect to other ...

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Номер записи: 26
30-01-2020 дата публикации

Process for the purification of acrolein

Номер: US20200031751A1
Автор: Bruno Krudewig, Haohao Zhu, Martin Koerfer, Michael Eicker, Rainer Malzkorn, Thorsten MERKER
Принадлежит: EVONIK DEGUSSA GmbH

The present invention relates to a process for purifying acrolein. The process includes the steps of a) splitting a liquid feed stream containing acrolein into at least a first liquid stream and a second liquid stream, b) introducing the first liquid stream with a temperature T 1 into a distillation column at a point between the top and the bottom of the distillation column, c) introducing the second liquid stream with a temperature T 2 into the distillation column at the top of the distillation column, d) withdrawing an overhead vapor stream enriched in acrolein from the distillation column, and e) withdrawing a bottom stream depleted in acrolein. The temperature T 2 of the second liquid stream in step c) is lower than the temperature T 1 of the first liquid stream in step b).

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Номер записи: 27
30-01-2020 дата публикации

POLYOL OR POLYTHIOL COMPOUND, PREPARATION METHOD THEREFOR, TRANSPARENT POLYURETHANE-BASED RESIN PREPARED THEREFROM, AND OPTICAL BODY

Номер: US20200031986A1
Автор: Kim Keun Sik
Принадлежит:

The present invention relates to a novel polyol or polythiol having three or more functional groups, a preparation method there for, and an optical body manufactured therefrom. Especially, the present invention relates to a poly(thio)urethane-based resin and an optical body, such as lenses, manufactured using the resin, wherein the poly(thio)urethane-based resin is prepared by obtaining a novel polyol and then combining a polythiol, which is prepared from the obtained polyol, with a polyiso(thio)cyanate. 123-. (canceled)25. The polyol compound according to claim 24 , as represented by Formula (a) or (b) claim 24 , wherein Y is an oxygen atom; Ra is a methyl or ethyl group; and Rb is one substituent selected from the group consisting of the following substituents:{'sub': 2', '2', '2', '2', '2', '2', '2', '2, '—CHCH(OH)CHF, —CHCH(OH)CHCl, —CHCH(OH)CHBr, —CHCH(OH)CHI,'}{'sub': 2', '2', '2', '2', '2', '3, '—CHCH(OH)CHSCHCH(OH)CHSCHCH(OH)CH,'}{'sub': 2', '2', '2', '2', '3', '2, '—CHCH(OH)CHSCHCH(OH)CHSCH(CH)CHOH,'}{'sub': 2', '2', '2', '3, '—CHCH(OH)CHSCHCH(OH)CH,'}{'sub': 2', '2', '3', '2, '—CHCH(OH)CHSCH(CH)CHOH,'}{'sub': 2', '2', '2', '2', '3, '—CHCH(OH)CHSCHCH(OH)CHCH,'}{'sub': 2', '2', '2', '3', '2, '—CHCH(OH)CHSCH(CHCH)CHOH,'}{'sub': 2', '2', '2', '2', '2', '2', '3, '—CHCH(OH)CHSCHCH(OH)CHSCHCH(OH)CHCH, and'}{'sub': 2', '2', '2', '2', '2', '3', '2, '—CHCH(OH)CHSCHCH(OH)CHSCH(CHCH)CHOH.'}26. The polythiol compound according to claim 24 , as represented by Formula (a) or (b) claim 24 , wherein Y is a sulfur atom; Ra is a methyl or ethyl group; and Rb is one substituent selected from the group consisting of the following substituents:{'sub': 2', '2', '2', '2', '3', '2, '—CH(CHSH)CHSH, —CHCH(CHSH)SCH(CH)CHSH,'}{'sub': 2', '2', '2', '3', '2', '2', '3', '2, '—CHCH(CHSH)SCHCH(CH)SH, —CH(CHSH)CHSCH(CH)CHSH,'}{'sub': 2', '2', '2', '3, '—CH(CHSH)CHSCHCH(CH)SH,'}{'sub': 2', '2', '2', '3', '2, '—CHCH(CHSH)SCH(CHCH)CHSH,'}{'sub': 2', '2', '2', '2', '3, '—CHCH(CHSH)SCHCH(CHCH)SH ...

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Номер записи: 28
09-02-2017 дата публикации

Metal-Catalyzed Oxidative Coupling of Thiols

Номер: US20170036998A1
Автор: Anantaneni Prakasa Rao, Harrington Ryan M., Laurent Boyd
Принадлежит: ECOLAB USA INC.

Disclosed are methods for preparing disulfide compounds through oxidative coupling of thiol compounds. Thiols are oxidized to the corresponding disulfide compound in high yield in presence of a base and a metal salt. The method uses low catalyst loadings and provides organic disulfide compounds with little to no byproducts. 2. The method of claim 1 , wherein the nickel salt is selected from the group consisting of nickel sulfate claim 1 , nickel acetate claim 1 , and a combination thereof.3. The method of claim 1 , wherein the organic base is triethylamine or triethanolamine.4. The method of claim 1 , wherein the molar ratio of the nickel salt to thiol is about 0.0005 to 1 or less.10. The method of claim 6 , wherein the nickel salt is selected from the group consisting of nickel sulfate claim 6 , nickel acetate claim 6 , and a combination thereof.11. The method of claim 6 , wherein the organic base is a tertiary amine.12. The method of claim 6 , wherein the molar ratio of the nickel salt to thiol is about 0.0005 to 1 or less.14. A method for producing a compound of formula (I) claim 6 , (II) claim 6 , or (III) or a salt thereof claim 6 , the method comprising:adding nitrogen to a reaction vessel comprising a thiol, a base, and a nickel salt;adding substantially pure oxygen to the reaction vessel after the nitrogen has been added; heating the reaction vessel;maintaining oxygen at the same pressure during reaction;wherein oxygen is added and maintained at a pressure less than the pressure of nitrogen.18. The method of claim 14 , wherein the nickel salt is selected from the group consisting of nickel sulfate claim 14 , nickel acetate claim 14 , and a combination thereof.19. The method of claim 14 , wherein the reaction vessel is maintained under an oxygen pressure of from about 50 psig to about 150 psig.20. The method of claim 14 , wherein the reaction vessel is maintained at a temperature of about 60° C. or less. This patent application claims the benefit of U.S. ...

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Номер записи: 29
09-02-2017 дата публикации

RADIATION-SENSITIVE RESIN COMPOSITION, RESIST PATTERN-FORMING METHOD, ACID GENERATOR AND COMPOUND

Номер: US20170038679A1
Автор: Asano Yusuke, KIMOTO Takakazu, Tomioka Hiroshi
Принадлежит: JSR Corporation

The present invention provides a radiation-sensitive resin composition that contains a polymer having a structural unit that includes an acid-labile group; and an acid generator, wherein the acid generator includes a compound including a sulfonate anion having SO, wherein a hydrogen atom or an electron-donating group bonds to an α carbon atom with respect to SO, and an electron-withdrawing group bonds to a β carbon atom with respect to SO; and a radiation-degradable onium cation. The compound preferably has a group represented by the following formula (1-1) or (1-2). In the following formulae (1-1) and (1-2), Rand Reach independently represent a hydrogen atom or a monovalent electron-donating group. Rrepresent a monovalent electron-withdrawing group. Rrepresents a hydrogen atom or a monovalent hydrocarbon group. 112-. (canceled)14: The radiation-sensitive resin composition according to claim 13 ,whereinn in the formula (2) is 1.15: The radiation-sensitive resin composition according to claim 13 , wherein the radiation-degradable onium cation is a sulfonium cation or an iodonium cation.17: The radiation-sensitive resin composition according to claim 13 , wherein a content of the first acid generator in the at least one acid generator is in a range of 25% by mass to 90% by mass.18: The radiation-sensitive resin composition according to claim 13 , wherein a content of the first acid generator in the at least one acid generator is in a range of 30% by mass to 70% by mass.19: The radiation-sensitive resin composition according to claim 13 , further comprising an acid diffusion controller.20: The radiation-sensitive resin composition according to claim 13 , further comprising a fluorine atom-containing polymer other than the polymer.21: The radiation-sensitive resin composition according to claim 13 , wherein Z represents a group represented by formula (1-1).22: The radiation-sensitive resin composition according to claim 21 , wherein n is 1.23: The radiation-sensitive ...

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Номер записи: 30
09-02-2017 дата публикации

Compound, polymer compound, resist composition, and patterning process

Номер: US20170038683A1
Автор: Jun Hatakeyama, Masahiro Fukushima, Masaki Ohashi, Takayuki Fujiwara
Принадлежит: Shin Etsu Chemical Co Ltd

The present invention provides a compound shown by the formula (1), wherein R 1 represents a hydrogen atom, a fluorine atom, a methyl group, or a trifluoromethyl group; A represents a single bond or a linear divalent hydrocarbon group having 1 to 30 carbon atoms or a branched or cyclic divalent hydrocarbon group having 3 to 30 carbon atoms, in which the hydrocarbon group may contain a heteroatom, and a part or all of hydrogen atoms in the hydrocarbon group may be substituted with a group containing a heteroatom; “n” represents 0 or 1, provided that “n” is 0 when A is a single bond; and M + represents a cation. This compound is suitable as a raw material of a polymer compound usable for a base resin of a resist composition that has high resolution and high sensitivity and is excellent in balance of lithography properties such as LWR and CDU.

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Номер записи: 31
01-05-2014 дата публикации

LOW VISCOSITY LUBRICATING OIL BASE STOCKS AND PROCESSES FOR PREPARING SAME

Номер: US20140121143A1
Автор: Bodige Satish, Luo Shuji, Patil Abhimanyu Onkar
Принадлежит: EXXONMOBIL RESEARCH AND ENGINEERING COMPANY

A composition that includes one or more compounds represented by the formula 2. The composition of wherein Rand Rare selected from the residue of a mPAO dimer (C-C) claim 1 , trimer (C-C) claim 1 , tetramer (C-C) claim 1 , pentamer (C-C) claim 1 , and hexamer (C-C) claim 1 , or α-olefin (C-C) claim 1 , X is selected from the residue of 1 claim 1 ,2-ethanedithiol claim 1 , 3-mercaptopropionate claim 1 , pentaerythritoltetrakis(3-mercaptopropionate) claim 1 , and trimethylopropanetris(3-mercaptopropionate) claim 1 , a is a value from 1 to 4 claim 1 , and b is a value or 0 or 1.3. The composition of having a Noack volatility of no greater than 20 percent.4. The composition of which is selected from a heteroatom-containing mPAO dimer claim 1 , trimer claim 1 , tetramer claim 1 , pentamer claim 1 , hexamer and higher oligomer claim 1 , or one or more compounds represented by a formula of .5. A composition comprising me or more heteroatom-containing hydrocarbon compounds claim 1 , wherein said one or more heteroatom-containing hydrocarbon compounds are produced by a process comprising reacting a polyalphaolefin oligomer or α-olefin (C-C) with an aliphatic polythiol claim 1 , aromatic polythiol claim 1 , cycloaliphatic polythiol claim 1 , ester or acid containing thiol claim 1 , or ester or acid containing polythiol claim 1 , optionally in the presence of a catalyst claim 1 , under reaction conditions sufficient to produce said one or more heteroatom-containing hydrocarbon compounds.6. The composition of wherein the process is carried out under reaction conditions sufficient to couple the polyalphaolefin oligomer or α-olefin (C-C) with the aliphatic polythiol claim 5 , aromatic polythiol claim 5 , cycloaliphatic polythiol claim 5 , ester or acid containing thiol claim 5 , or ester or acid containing polythiol claim 5 , to produce said heteroatom-containing hydrocarbon compound.7. The composition of having a viscosity (Kv) from 2 to 30 at 100° C. claim 5 , a viscosity index ...

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Номер записи: 32
19-02-2015 дата публикации

USE OF 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES FOR TREATING LIVER DISORDERS

Номер: US20150051145A1
Автор: DARTEIL Raphael, DUFOUR Ingrid, HANF Rémy, HUM Dean
Принадлежит: GENFIT

The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular those requiring the reduction of plasma level of biochemical markers such as aminotransferases. The 1,3-diphenylprop-2-en-1-one derivatives of General Formula (I) have hepatoprotective properties and can be used in methods for treating liver disorders involving the pathological disruption, inflammation, degeneration, and/or proliferation of liver cells, such as liver fibrosis or fatty liver disease. 2. The method of wherein the compound is of general formula (I) in which:X1 represents a halogen, a R1, or a G1-R1 group;A represents a CH═CH group;X2 represents a G2-R2 group;G1 and G2, identical or different, represent an atom of oxygen or sulfur;R1 represents an alkyl or cycloalkyl group having from one to seven carbon atoms, in particular, the alkyl or cycloalkyl group being substituted or not by one or more halogen atoms;R2 represents an alkyl group substituted by a —COOR3 group, wherein R3 represents a hydrogen atom or an alkyl group having from one to four carbon atoms.R4 and R5 represent an alkyl group having from one to four carbon atoms.3. The method of wherein the compound is of general formula (I) in which:X1 represents a R1 or G1-R1 group;A represents a CH2-CH2 group;X2 represents a G2-R2 group;G1 represents an atom of oxygen or sulfur and G2 represents an atom of oxygen;R1 represents an alkyl or cycloalkyl group having from one to seven carbon atoms;R2 represents an alkyl group substituted by at least a —COOR3 group, wherein R3 represents a hydrogen atom or an alkyl group having from one to four carbon atoms;R4 and R5 represent an alkyl group having from one to four carbon atoms.4. The method of wherein the compound is of general formula (I) in which:X1 represents a halogen atom or a R1 or G1-R1 group;A represents a CH2-CH2 group;X2 represents a G2-R2 group;G1 represents an atom of oxygen or sulfur ...

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Номер записи: 33
08-05-2014 дата публикации

METHOD FOR DETERMINING THE PRESENCE OR ABSENCE OF A BIOMARKER

Номер: US20140127709A1
Автор: Baird Mark Stephen, Gwenin Christopher David, Gwenin Vanessa Valerie, Pitts Mark
Принадлежит: Bangor University

A method of determining the presence or absence in a sample of a biomarker, the method comprising: (a) linking an antigen to colloidal gold to provide a gold-antigen species; (b) contacting the gold-antigen species with the sample; (c) adding a diagnosis agent to the sample; and (d) observing the colour of the sample. 1. A method of determining the presence or absence in a sample of a biomarker , the method comprising:(a) linking an antigen to colloidal gold to provide a gold-antigen species;(b) contacting the gold-antigen species with the sample;(c) adding a diagnosis agent to the sample; and(d) observing the colour of the sample.2. A method according to wherein the biomarker is a disease antibody indicative of infection with a mycobaterial disease.3. A method according to wherein the biomarker is a disease antibody indicative of the presence of tuberculosis.4. A method according to claim 1 , wherein the antigen is a mycolic acid derived antigen selected from one or more of the following classes of compounds:(i) mycolic acids obtained from natural sources;(ii) synthetically prepared mycolic acids;(iii) salts of mycolic acids;(iv) esters of mycolic acids (i) and/or (ii);(v) sulfur-containing mycolic acids and/or salts or esters thereof;(vi) simple structural analogues of mycotic acids and/or salts or esters thereof.5. A method according to claim 1 , wherein the antigen is linked to the gold by a gold-sulfur bond.6. A method according to wherein the antigen is directly bonded to the colloidal gold by a sulfur atom contained within the antigen molecule.7. A method according to wherein the antigen is linked to the colloidal gold via a sulfur-containing linker compound.8. A method according to claim 1 , wherein the diagnosis agent is an aqueous composition having one or more salts dissolved therein.9. A method according to claim 1 , in which step (d) involves visually observing the presence or absence of a colour change to provide a qualitative assessment.10. A method ...

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Номер записи: 34
25-02-2016 дата публикации

ORGANOCATALYSTS OF OXIDATIVE PROTEIN FOLDING

Номер: US20160052878A1
Автор: III John C., Lukesh, RAINES Ronald T.
Принадлежит:

Catalysts of protein-disulfide isomerization of formula: 2. The compound of claim 1 , wherein the calculated logP of (CH)NRis greater than or equal to 0.3. The compound of claim 1 , wherein each Rand each Rare hydrogens.4. The compound of claim 1 , wherein Ris —COR.5. The compound of claim 4 , wherein Ris an alkyl group having 1-20 carbon atoms or an alkenyl group having 3-20 carbon atoms.6. The compound of claim 4 , wherein Ris an alkyl group having 1-6 carbon atoms.7. The compound of claim 4 , wherein Ris an aromatic group having 6-12 carbon atoms.8. The compound of claim 4 , wherein Ris a cyclopentyl claim 4 , cyclohexyl claim 4 , cyclooctyl claim 4 , cyclononyl claim 4 , cyclodecyl claim 4 , cyclopentenyl claim 4 , cyclohexenyl claim 4 , cyclooctenyl claim 4 , cyclononenyl or cyclodecenyl group.9. The compound of claim 4 , wherein Ris a phenyl claim 4 , benzyl claim 4 , biphenyl claim 4 , naphthyl claim 4 , indanyl or indenyl group.10. The compound of claim 4 , wherein Ris an alkyl-substituted phenyl group.11. The compound of claim 1 , wherein R claim 1 , each Rand each of Rare hydrogens.12. The compound of claim 1 , wherein each Rand each of Rare hydrogens and Ris —COR claim 1 , where Ris an unsubstituted straight-chain or branched alkyl group having 3-6 carbon atoms.13. The compound of claim 1 , wherein each Rand each of Rare hydrogens and Ris —COR claim 1 , where Ris a phenyl claim 1 , benzyl claim 1 , phenethyl claim 1 , or an alkyl-substituted phenyl group.14. The compound of claim 1 , wherein each Rand each of Rare hydrogens and Ris —COR claim 1 , where Ris an unsubstituted cycloalkyl group having 5-8 carbon atoms.15. The compound of claim 1 , wherein each Ris —COR.16. The compound of claim 1 , wherein each Ris —COR claim 1 , each Ris hydrogen and Ris —COR.17. A refolding buffer comprising one or more compounds of .18. A method for forming a disulfide bond in a polypepetide or protein containing at least two cysteines which comprises contacting the ...

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Номер записи: 35
25-02-2016 дата публикации

SUBSTITUTED BICYCLIC COMPOUNDS

Номер: US20160052888A1
Автор: Dhar T.G. Murali, Dyckman Alaric J., Gilmore John L., Marcoux David, Xiao Hai-Yun, Xiao Zili, Yang Michael G.
Принадлежит:

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): 3. The compound according to claim 2 , having the structure of Formula (I) or a salt thereof claim 2 , wherein:{'sub': 1', '2, 'Ris —OH or —OP(O)(OH);'}{'sub': 2', '2a', '2b, 'Ris Ror R;'}{'sub': '2a', 'claim-text': [{'sub': 2', '3', '3', '2', '5', '3', '2', '2', '3', '2', '2', '2', '3', '2', '3', '3', '2', '3', '3', '2', '2', '4', '2', '2', '4', '3', '2', '3', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '3', '2', '3', '2', '2', '2', '3, 'is —(CH)CH, —(CH)CH, —CHCH═CHCHCH, —CHCHCH═CHCHCH, —(CH)CH═CHCH, —(CH)CH═C(CH), —(CH)CH═CH, —(CH)CH═CHCH, —CH═C H(CH)CH, —CH═CH(CH)OCH, —CH═CHCHCHCH(CH), —CH═CHCHCHCHOCH, —CHCH═CHCH═CHCH, —CH═CHCHCHCH═CH, —CH═CH(phenyl) wherein said phenyl is substituted with —CH'}, {'sub': 3', '2', '1-3', '3', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '2', '2', '1-2, 'or —OCH; —CH═CH(tetrahydropyranyl), —(CH)(phenyl) wherein said phenyl is substituted with zero to 2 substituents independently selected from F, I, —CH, —OCH, —OCHCH, —OCH(CH), and —CHC(O)N(CH); —(CH)(methyl imidazolyl), —(CH)(methyl pyrazolyl), —(CH)(pyridinyl) wherein said pyridinyl is substituted with zero to 1 substituent selected'}, {'sub': 3', '2', '2', '2', '2', '2', '2-3', '2', '2', '3-4', '3', '2', '2', '2', '3', '2', '2', '2', '2', '3', '3', '2', '2', '9', '3', '2', '2', '2', '2', '3', '2', '2', '2', '3', '2', '2', '3', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '3', '2', '3', '3', '2', '3', '3', '3', '3', '2', '1-6', '3', '3', '2', '2', '3', '2', '2', '3', '3', '3', '2', '2', '2', '3, 'from —OCH; —(CH)(pyrimidinyl), —(CH)(quinolinyl), —(CH)(tetrahydropyranyl), —CHO(CH)CH, —CHOCHCHCH(CH), —CHOCHCHC(CH), —CHO(CH)CH, —CHOCHCHCHCF, —CHOCHCH═CHCHCH, —CHOCHCH═C(CH), —CHOCHCH═CHCHCHCH, — ...

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Номер записи: 36
08-05-2014 дата публикации

PROCESS TO PREPARE CROSSLINKABLE TRIFLUOROSTYRENE POLYMERS AND MEMBRANES

Номер: US20140128560A1
Автор: Roelofs Mark Gerrit, Teasley Mark F.
Принадлежит: E I DU PONT DE NEMOURS AND COMPANY

Described herein is a trifluorostyrene compound that can be used as a monomer to form crosslinkable polymers, and their use as polymer electrolyte membranes. 2. The compound of wherein Rf′ is selected from the group consisting of (CF)wherein r=1 to 20 claim 1 , (CFCF)OCFCFwherein r=1 to 6 claim 1 , and (CFCF(CF)O)CFCFwherein r=1 to 8.3. The compound of wherein Rf′ is (CF)wherein r=1 to 4.4. The compound of wherein X is Br.5. The compound of wherein n is 1 and T is S or SO.7. A copolymer prepared from the compound of .9. The copolymer of wherein (II) is present at 0.01 to 0.10 mole % and (I) is present at 0.99 to 0.90 mole %.10. The copolymer of wherein Rf and Rf′ are independently selected from the group consisting of (CF)wherein r=1 to 20 claim 8 , (CFCF)OCFCFwherein r=1 to 6 claim 8 , and (CFCF(CF)O)CFCFwherein r=1 to 8.11. The copolymer of wherein Rf and Rf′ are selected from the group consisting of (CF)wherein r=1 to 4.12. The copolymer of wherein Q is F and X is Br.13. The copolymer of wherein M is H.14. The copolymer of wherein the copolymer is crosslinked.16. The copolymer of wherein (VII) is present at less than 10 mole %.17. The copolymer of wherein n is 1 in both Formula I and Formula II claim 8 , and T is S or SO.19. A membrane comprising the copolymer of .20. The membrane of wherein Rf and Rf′ are independently selected from the group consisting of (CF)wherein r=1 to 20 claim 19 , (CFCF)OCFCFwherein r=1 to 6 claim 19 , and (CFCF(CF)O)CFCFwherein r=1 to 8.21. An electrochemical cell comprising the membrane of .22. The electrochemical cell of that is a fuel cell. Described herein is a process to prepare crosslinkable polymers based on trifluorostyrene, and their use as polymer electrolyte membranes.Polymer electrolyte membrane fuel cells (PEMFC) are expected to provide higher efficiencies, fewer environmental pollutants, and reduced operating and maintenance costs than traditional power sources. An important component of a PEMFC is a polymer electrolyte ...

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Номер записи: 37
23-02-2017 дата публикации

Sulfur derivatives as chemokine receptor modulators

Номер: US20170050925A9
Автор: Haiqing Yuan, John E. Donello, Michael E. Garst, Richard L. Beard, Veena Viswanath, Xiaoxia Liu
Принадлежит: Allergan Inc

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

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Номер записи: 38
20-02-2020 дата публикации

4-DIFLUOROMETHYL BENZOYL AMIDES WITH HERBICIDAL ACTION

Номер: US20200055829A1
Автор: AHRENS HARTMUT, Dietrich Hansjoerg, GATZWEILER ELMAR, MACHETTIRA Anu Bheemaiah, ROSINGER CHRISTOPHER HUGH, Tiebes Joerg, WALDRAFF CHRISTIAN
Принадлежит:

Benzoylamides of the general formula (I) are described as herbicides. 6. A herbicidal composition comprising at least one compound as claimed in mixed with one or more formulation auxiliaries.7. The herbicidal composition as claimed in claim 6 , comprising at least one further pesticidally active substance selected from the group consisting of insecticides claim 6 , acaricides claim 6 , herbicides claim 6 , fungicides claim 6 , safeners claim 6 , and growth regulators.8. A method for controlling one or more unwanted plants claim 1 , comprising applying an effective amount of at least one compound of the formula (I) as claimed in or of herbicidal compositions thereof to the plants or a site of unwanted vegetation.9. A product comprising a compound as claimed in or of herbicidal compositions thereof for controlling one or more unwanted plants.10. The product as claimed in claim 9 , wherein the compound is used for controlling unwanted plants in one or more crops of useful plants.11. The product as claimed in claim 10 , wherein the useful plants are transgenic useful plants.13. The compound as claimed in claim 12 , in whichX represents cyclopropyl, fluorine, chlorine, bromine or iodine,R represents methyl, ethyl, cyclopropylmethyl or methoxyethyl,n represents 0, 1 or 2.15. The compound as claimed in claim 14 , in whichX represents methyl, ethyl, cyclopropyl, fluorine, chlorine, bromine or iodine,R represents methyl, ethyl, cyclopropylmethyl or methoxyethyl,n represents 0, 1 or 2. The invention relates to the technical field of the herbicides, especially that of the herbicides for selective control of weeds and weed grasses in crops of useful plants.WO 2011/035874 A1, WO 2012/126932 A1, WO 2012/028579 A1 and WO 2016/146561 A1 describe herbicidally active benzoylamides which differ from one another essentially by the nature of the heterocyclic substituent. These benzoylamides may be substituted in the 2-, 3- and 4-positions of the phenyl ring by a large number of ...

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Номер записи: 39
01-03-2018 дата публикации

PHOTOACID-GENERATING COMPOUND, POLYMER DERIVED THEREFROM, PHOTORESIST COMPOSITION INCLUDING THE PHOTOACID-GENERATING COMPOUND OR POLYMER, AND METHOD OF FORMING A PHOTORESIST RELIEF IMAGE

Номер: US20180059542A1
Автор: Aqad Emad, III William, LIU Cong, Williams
Принадлежит:

A photoacid-generating compound has the structure 8. A polymer comprising repeat units derived from the photoacid-generating compound of .9. A photoresist composition comprising the photoacid-generating compound of .10. A method of forming a photoresist relief image claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00009', 'claim 9'}, '(a) applying a layer of the photoresist composition of on a substrate to form a photoresist layer;'}(b) pattern-wise exposing the photoresist layer to activating radiation to form an exposed photoresist layer; and(c) developing the exposed photoresist layer to provide a photoresist relief image.11. A photoresist composition comprising the polymer of . The present invention relates to a photoacid-generating compound, a polymer formed from an embodiment of the photoacid-generating compound comprising a polymerizable group, a photoresist composition comprising the photoacid-generating compound, the polymer, or a combination thereof, and a method of forming a photoresist relief image with the photoresist composition.Advance lithographic techniques such as electron beam and Extreme Ultraviolet (EUV) lithographies are being used for the formation of fine patterns. Further shrinking of pattern size to 25 nanometers and less requires, in addition to other process and exposure tool related requirements, the development of highly resolving chemically amplified photoresist compositions. The use of slow diffusion photoacid-generating (PAG) compounds has proved to be critical for the improvement in resolution and pattern quality. Slow acid diffusion in a chemically amplified photoresist composition was achieved by attaching the acidic unit to one or more bulky substituents. However, the use of bulky substituents often decreases the solubility of the PAG compound, which is associated with PAG compound aggregation and/or inhomogeneous PAG compound distribution in the photoresist layer, and with the formation of defects during and after lithographic ...

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Номер записи: 40
17-03-2022 дата публикации

METHODS OF PREPARING SUBSTITUTED INDANES

Номер: US20220081407A1
Автор: Spencer Stacey Renee, STENGEL Peter J., Xu Rui
Принадлежит: Peloton Therapeutics, Inc.

This application discloses methods for the synthesis of substituted indane analogs that modulate HIF-2α activity, as well as key intermediates produced thereby. The synthesis of 3-(((1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl)oxy)-5-fluorobenzonitrile was exemplified. 12-. (canceled)315-. (canceled)1618-. (canceled)1934-. (canceled)3536-. (canceled)3760-. (canceled)6166-. (canceled)6771-. (canceled)72. (canceled)74. (canceled)7680-. (canceled) This application is a U.S. non-provisional application which claims the benefit of provisional Application No. 62/901,669, filed Sep. 17, 2019.An adequate supply of oxygen to tissues is essential in maintaining mammalian cell function and physiology. A deficiency in oxygen supply to tissues is a characteristic of a number of pathophysiologic conditions in which there is insufficient blood flow to provide adequate oxygenation. The hypoxic (low oxygen) environment of tissues activates a signaling cascade that drives the induction or repression of the transcription of a multitude of genes implicated in events such as angiogenesis (neo-vascularization), glucose metabolism, and cell survival/death. A key to this hypoxic transcriptional response lies in the transcription factors, the hypoxia-inducible factors (HIF). HIFs are dysregulated in a vast array of cancers through hypoxia-dependent and independent mechanisms and expression is associated with poor patient prognosis.HIFs consist of an oxygen-sensitive HIFα subunit and a constitutively expressed HIFβ subunit. When HIFs are activated, the HIFα and HIFβ subunits assemble a functional heterodimer (the a subunit heterodimerizes with the β subunit). Both HIFα and HIFβ have two identical structural characteristics, a basic helix-loop-helix (bHLH) and PAS domains (PAS is an acronym referring to the first proteins, PER, ARNT, SIM, in which this motif was identified). There are three human HIFα subunits (HIF-1α, HIF-2α, and HIF-3α) that are oxygen ...

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Номер записи: 41
12-03-2015 дата публикации

LIQUID CRYSTAL COMPOUND HAVING TETRAFLUOROPROPENYL, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY ELEMENT

Номер: US20150069297A1
Автор: Tanaka Hiroyuki
Принадлежит:

A liquid crystal compound having high stability to heat and light, etc., a high clearing point, a low minimum temperature of liquid crystal phase, a low viscosity, a suitable optical anisotropy, a large dielectric anisotropy, a suitable elastic constant, and good compatibility with other liquid crystal compounds, a liquid crystal composition containing the compound, and a LCD element using the composition are described. The compound is represented by formula (1): 2. The compound of claim 1 , wherein in formula (1) claim 1 , ring Bis 1 claim 1 ,4-cyclohexylene claim 1 , 1 claim 1 ,4-phenylene claim 1 , or 1 claim 1 ,4-phenylene in which at least one hydrogen is substituted with halogen.3. The compound of claim 1 , wherein in formula (1) claim 1 , Ris Calkyl claim 1 , Calkenyl claim 1 , Calkoxy claim 1 , or Calkenyloxy claim 1 , and Z claim 1 , Z claim 1 , Zand Zare independently a single bond claim 1 , —(CH)— claim 1 , —CH═CH— claim 1 , —COO— claim 1 , —OCO— claim 1 , —CFO— claim 1 , —OCF— claim 1 , or —CF═CF—.4. The compound of claim 1 , wherein in formula (1) claim 1 , Ris Calkyl or Calkenyl claim 1 , and Z claim 1 , Z claim 1 , Zand Zare independently a single bond claim 1 , —(CH)— claim 1 , —CH═CH— claim 1 , —COO— claim 1 , or —CFO—.5. The compound of claim 1 , wherein in formula (1) claim 1 , Ris Calkyl or Calkenyl claim 1 , ring A claim 1 , ring A claim 1 , ring Aand ring Aare independently 1 claim 1 ,4-cyclohexylene claim 1 , 1 claim 1 ,4-phenylene claim 1 , 1 claim 1 ,4-phenylene in which at least one hydrogen is substituted with halogen claim 1 , 1 claim 1 ,3-dioxane-2 claim 1 ,5-diyl claim 1 , or tetrahydropyran-2 claim 1 ,5-diyl claim 1 , ring Bis 1 claim 1 ,4-cyclohexylene claim 1 , 1 claim 1 ,4-phenylene claim 1 , or 1 claim 1 ,4-phenylene in which at least one hydrogen is substituted with halogen claim 1 , and Z claim 1 , Z claim 1 , Zand Zindependently a single bond claim 1 , —(CH)— claim 1 , or —CH═CH—.11. A liquid crystal composition claim 1 , ...

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Номер записи: 42
08-03-2018 дата публикации

INTRODUCTION OF ALKYL SUBSTITUENTS TO AROMATIC COMPOUNDS

Номер: US20180065904A1
Автор: Pappo Doron, PARNES Regev
Принадлежит:

Novel selective synthesis route to introduce primary alkyl groups on aromatic compounds is disclosed. The synthesis route is based on electrophilic aromatic substitutions of thionium ion species that are generated in-situ from aldehydes and thiols, affording benzyl sulfide that can be reduced with triethylsilane. 2. The process of claim 1 , wherein Ris ethyl.3. The process of claim 1 , wherein said acidic catalyst is one or more Lewis acid selected from the group consisting of: CuCl claim 1 , Sc(OTf) claim 1 , Fe(OTf) claim 1 , In(OTf) claim 1 , BF3.OEt claim 1 , and Cu(OTf).4. The process of claim 1 , wherein said acidic catalyst is one or more Brønsted acids selected from the group consisting of: Triflic acid (TfOH) claim 1 , para-toluenesulfonic acid claim 1 , and trifluoroacetic acid.5. The process of claim 1 , wherein said suitable solvent is a polar solvent selected from the group consisting of: acetonitrile claim 1 , nitromethane claim 1 , and 2 claim 1 ,2 claim 1 ,2-trifluoroethanol (TFE) claim 1 , hexafluoroisopropanol (HFIP) or a mixture thereof.6. The process of claim 1 , characterized by at least 30% yield of the compound represented by Formula I.8. The process of claim 7 , wherein said reducing agent is a silane.9. The process of claim 8 , wherein said silane is EtSiH.14. A pharmaceutical composition comprising a product according to and a pharmaceutically acceptable excipient.15. A composition comprising:{'sub': 2', '3', '3', '3', '3', '2', '2, '(i) one or more Lewis acids selected from the group consisting of: CuCl, Sc(OTf), Fe(OTf), In(OTf), BF.OEt, TfOH and Cu(OTf);'}(ii) a polar solvent selected from the group consisting of: acetonitrile, nitromethane, and 2,2,2-trifluoroethanol (TFE), or a mixture thereof; and(iii) RSH, wherein R is selected from the group consisting of: alkyl, benzyl, alkoxy, aryloxy, carbonyl, and carboxy, substituted or non-substituted.16. The composition of claim 15 , wherein said Lewis acid is in a molar concentration of at ...

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Номер записи: 43
08-03-2018 дата публикации

POLYMERIZABLE COMPOSITION AND NOVEL ALKYNE COMPOUND

Номер: US20180066082A1
Автор: ANDO Tomoyuki, MURAKAMI Masakazu
Принадлежит: Mitsui Chemicals, Inc.

Provided is a polymerizable composition including an alkyne compound represented by the following general formula (1): 4. The polymerizable composition according to claim 1 , further comprising a thiol compound.5. The polymerizable composition according to claim 4 , wherein the thiol compound includes at least one kind of polythiol compounds selected from 4-mercaptomethyl-1 claim 4 ,8-dimercapto-3 claim 4 ,6-dithiaoctane claim 4 , 4 claim 4 ,8 or 4 claim 4 ,7 or 5 claim 4 ,7-dimercaptomethyl-1 claim 4 ,11-dimercapto-3 claim 4 ,6 claim 4 ,9-trithiaundecane claim 4 , pentaerythritol tetrakis(2-mercaptoacetate) claim 4 , pentaerythritol tetrakis(3-mercaptopropionate) claim 4 , 2 claim 4 ,5-bis(mercaptomethyl)-1 claim 4 ,4-dithiane claim 4 , bis(mercaptoethyl)sulfide claim 4 , 1 claim 4 ,1 claim 4 ,3 claim 4 ,3-tetrakis(mercaptomethylthio)propane claim 4 , 4 claim 4 ,6-bis(mercaptomethylthio)-1 claim 4 ,3-dithiane claim 4 , and 2-(2 claim 4 ,2-bis(mercaptomethylthio)ethyl)-1 claim 4 ,3-dithietane.6. A molded product obtained by curing the polymerizable composition according to .7. An optical material comprised of the molded product according to .8. A plastic lens comprised of the molded product according to . The present invention relates to a polymerizable composition and a novel alkyne compound.In recent years, a transparent organic polymer material has been used as a transparent material to replace inorganic glass. In the case where such a material is used in, for example, optical applications such as spectacle lenses, it is required to have a high refractive index while having generally required properties such as transparency, thermal properties, and mechanical properties.As a related art relating to such a resin, Patent Document 1 describes examples of using a compound having a disulfide bond. Further, Non-Patent Document 1 describes that a resin is obtained by copolymerizing a compound having sulfur atom and a triple bond with a polythiol, although optical ...

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Номер записи: 44
29-05-2014 дата публикации

SPECIFIC CARBOXAMIDES AS KCNQ2/3 MODULATORS

Номер: US20140148468A1
Автор: Bahrenberg Gregor, Kühnert Sven, LUCAS Simon, Schröder Wolfgang
Принадлежит: Grünenthal GmbH

The invention relates to specific carboxamides, to processes for their preparation, to medicaments comprising these compounds and to the use of these compounds in the preparation of medicaments. 3. The compound according to claim 1 , wherein{'sup': '1', 'Arepresents S; and'}{'sup': 2', '12', '13, 'sub': '2', 'claim-text': {'sup': 12', '13, 'wherein Rand Rboth represent H or both represent F.'}, 'Arepresents S, S(═O)or CRR,'}4. The compound according to claim 1 ,wherein{'sup': 3', '7', '4', '7', '5', '7', '6', '7, 'n denotes 1 and Arepresents CR, Arepresents CR, Arepresents CRand Arepresents CR; or'}{'sup': 3', '4', '7', '5', '7', '6', '7, 'n denotes 1 and Arepresents N, Arepresents CR, Arepresents CRand Arepresents CR; or'}{'sup': 3', '7', '4', '5', '7', '6', '7, 'n denotes 1 and Arepresents CR, Arepresents N, Arepresents CRand Arepresents CR; or'}{'sup': 3', '7', '4', '7', '5', '6', '7, 'n denotes 1 and Arepresents CR, Arepresents CR, Arepresents N and Arepresents CR; or'}{'sup': 3', '4', '5', '7', '6', '7, 'n denotes 1 and Arepresents N, Arepresents N, Arepresents CRand Arepresents CR; or'}{'sup': 3', '4', '7', '5', '6', '7, 'n denotes 1 and Arepresents N, Arepresents CR, Arepresents N and Arepresents CR; or'}{'sup': 3', '4', '7', '5', '7', '6, 'n denotes 1 and Arepresents N, Arepresents CR, Arepresents CRand Arepresents N; or'}{'sup': 3', '7', '4', '5', '7', '6, 'n denotes 1 and Arepresents CR, Arepresents N, Arepresents CRand Arepresents N; or'}{'sup': 3', '7', '4', '5', '6', '7, 'n denotes 1 and Arepresents CR, Arepresents N, Arepresents N and Arepresents CR; or'}{'sup': 3', '7', '4', '7', '5', '6, 'n denotes 1 and Arepresents CR, Arepresents CR, Arepresents N and Arepresents N; or'}{'sup': 3', '4', '7', '5', '7, 'n denotes 0 and Arepresents S, Arepresents CRand Arepresents CR;'}or{'sup': 3', '4', '7', '5, 'n denotes 0 and Arepresents S, Arepresents CRand Arepresents N;'}or{'sup': 3', '4', '7', '5', '7, 'n denotes 0 and Arepresents O, Arepresents CRand ...

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Номер записи: 45
11-03-2021 дата публикации

Reagents and Methods for Analysis of Proteins and Metabolites Targeted by Covalent Probes

Номер: US20210072254A1
Автор: Adelmant Guillaume, Ficarro Scott B, Marto Jarrod A
Принадлежит:

The present application relates to mass spectrometry methods for use in identifying proteins or other biomolecules which are bound irreversibly by test compounds. 1. An analytical method , comprising:i) contacting a broad thiol reactive compound with a polypeptide to form a broad thiol reactive compound-polypeptide conjugate;ii) analyzing the broad thiol reactive compound-polypeptide conjugate using a mass spectrometry assay;iii) detecting one or more thiolated ions of the broad thiol reactive compound, or derivative ions thereof, produced in the mass spectrometry assay; andiv) identifying that the broad thiol reactive compound forms an irreversible bond with the polypeptide based on the detection of the one or more thiolated ions, or derivative ions thereof, in the mass spectrometry assay;wherein the thiolated ions or derivatives thereof are fragment ions.2. The method of claim 1 , wherein the compound-polypeptide conjugate comprises one or more thioether bonds between the compound and the polypeptide.3. The method of claim 1 , wherein the irreversible bond is an irreversible covalent bond.4. The method of claim 1 , wherein step i) comprises contacting the compound and the polypeptide in the presence of a first solvent component.5. The method of claim 1 , wherein step i) further comprises contacting the compound and the polypeptide in the presence of a buffer agent.6. The method of claim 1 , wherein step i) is performed using a molar excess of the compound compared to the polypeptide.7. The method of claim 1 , further comprising contacting the broad thiol reactive compound-polypeptide conjugate with an acid in the presence of a second solvent component prior to performing the mass spectrometry assay of step ii).8. The method of claim 1 , wherein the method further comprises digesting the broad thiol reactive compound-polypeptide conjugate prior to the performing the mass spectrometry assay of step ii).9. The method of claim 8 , wherein the digesting comprises ...

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Номер записи: 46
07-03-2019 дата публикации

SUBSTITUTED 3-HALOALLYLAMINE INHIBITORS OF SSAO AND USES THEREOF

Номер: US20190071396A1
Автор: Deodhar Mandar, Findlay Alison Dorothy, Foot Jonathan Stuart, Jarolimek Wolfgang, Mcdonald Ian Alexander, Robertson Alan Duncan, Turner Craig Ivan
Принадлежит:

The present invention is related to the preparation and pharmaceutical use of substituted 3-haloallylamine derivatives as SSAO/VAP-1 inhibitors having the structure of Formula I, as defined in the specification: 2. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris hydrogen and Ris methyl; or Ris methyl and Ris hydrogen.3. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Rand Rare both hydrogen.4. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein Ris an unsubstituted phenylene group or a phenylene group substituted by one or more groups independently selected from methyl claim 1 , fluorine claim 1 , chlorine claim 1 , bromine claim 1 , OCHand CF.5. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein{'sup': 7', '8, 'Rand Rare both hydrogen,'}{'sup': 7', '8, 'sub': '1-6', 'Rand Rare both Calkyl, or'}{'sup': 7', '8, 'sub': '1-6', 'Ris hydrogen and Ris Calkyl.'}6. The compound of claim 1 , or a pharmaceutically acceptable salt thereof claim 1 , wherein X is oxygen.9. The compound of wherein said compound is (E)-4-(2-(aminomethyl)-3-fluoroallyloxy) -N-tert-butylbenzamide or a pharmaceutically acceptable salt thereof.10. A pharmaceutically acceptable salt of a compound according to .11. The pharmaceutically acceptable salt according to characterized in that it is an acid addition salt.12. The pharmaceutically acceptable salt according to characterized in that the acid addition salt is selected from the group consisting of hydrochlorides claim 11 , hydrobromides claim 11 , sulfates claim 11 , formates claim 11 , acetates claim 11 , lactates claim 11 , malates claim 11 , tartrates claim 11 , citrates claim 11 , ascorbates claim 11 , succinates claim 11 , maleates claim 11 , butyrates claim 11 , valerates and fumarates.13. The pharmaceutically acceptable salt of wherein said pharmaceutically acceptable salt is (E)-4 ...

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Номер записи: 47
05-03-2020 дата публикации

LOW FREE 2-MERCAPTOETHANOL ESTER AND USES THEREOF

Номер: US20200071269A1
Автор: DUNLAP Jeremy, NORRIS Gene Kelly, ROSS Kevin John
Принадлежит: PMC ORGANOMETALLIX, INC.

A novel Low Free 2-MercaptoEthanol Ester has been used to prepare Alkyl Tin Reverse Ester Stabilizers as well as used to enhance the thermal performance of those Alkyl Tin Reverse Ester Stabilizers or Alkyl Tin Thioglycolate Stabilizers or Alkyl Tin Mercaptides for PVC applications where odor during PVC compounding, processing, or of the final PVC article has prevented widespread use of Alkyl Tin Reverse Ester Stabilizers. 1. A Low Free 2-MercaptoEthanol Ester (LFMEE) that is obtained through removal of 2-MercaptoethylEthanol from a standard 2-MercaptoEthanol Ester , wherein the resulting LFMEE have residual 2-Mercaptoethanol below 1.0 wt %.2. The LFMEE of wherein the resulting LFMEE have residual 2-Mercaptoethanol below 0.7 wt %.3. The LFMEE of wherein the resulting LFMEE have residual 2-Mercaptoethanol below 0.5 wt %.4. A method of using the LFMEE of to enhance thermal performance of alkyl tin thioglycolate ester stabilizers.5. A method of using the LFMEE of to enhance thermal performance of alkyl tin reverse ester stabilizers.6. A method of using the LFMEE of to enhance thermal performance of alkyl tin mercaptide stabilizers.7. The method of wherein the mercaptide can be dodocylmercaptan or carboxylates.8. The method of wherein the mercaptide is Maleates.9. The method of wherein the stabilizer further includes sulfide bridging for alkyl groups ranging of C1-C8.10. The method of wherein the alkyl tin mercaptide stabilizer has alkyl tin groups having both mono and di components claim 6 , wherein the mono and di components of alkyl tin groups are in ratios ranging from 100% di to 100% mono and all combinations between.11. The method of wherein the amount of LFMEE used in the stabilizer can range from 5 wt % to 75 wt %.12. The method of wherein the amount of LFMEE used in the stabilizer can range from 10 wt % to 40 wt %.13. The method of wherein the stabilizer further includes Ca/Zn-based boosters claim 4 , organic-based stabilizers and/or other traditional ...

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Номер записи: 48
22-03-2018 дата публикации

Mixed Decyl Mercaptans Compositions and Methods of Making Same

Номер: US20180079718A1
Автор: Byers Jim D., KREIDER Jason L., Matson Michael S.
Принадлежит:

Compositions comprising branched Cmercaptans selected from the group consisting of 5-methyl-1-mercapto-nonane, 3-propyl-1-mercapto-heptane, 4-ethyl-1-mercapto-octane, 2-butyl-1-mercapto-hexane, 5-methyl-2-mercapto-nonane, 3-propyl-2-mercapto-heptane, 4-ethyl-2-mercapto-octane, 5-methyl-5-mercapto-nonane, and combinations thereof. Compositions comprising C mercaptans, wherein the C mercaptans are characterized by structure R—SH, wherein Ris an alkyl group derived from one or more C monoolefins, and wherein the one or more C monoolefins comprise Cinternal monoolefins, Cinternal monoolefins, Cinternal monoolefins, Cinternal monoolefins, 1-tetradecene, 1-hexadecene, or combinations thereof. Compositions comprising branched C mercaptans, wherein the branched C mercaptans are characterized by structure R—SH, wherein Ris an alkyl group derived from one or more branched Cto Cmonoolefins. 1. A composition comprising C mercaptans , wherein at least about 50 wt. % of the C mercaptans are branched Cto Cmercaptans characterized by the general formula R—SH , wherein Ris a branched alkyl group; and wherein Rhas from 10 to 30 carbon atoms.3. The composition of claim 1 , wherein Ris a Cto Calkyl group.4. A composition comprising C sulfides claim 1 , wherein at least about 50 wt. % of the C sulfides are branched Cto Csulfides represented by structure R—S—R claim 1 , wherein Rand Rare each independently a functional group derived from an olefin claim 1 , and wherein the olefin comprises a branched Cto Cmonoolefin.6. The composition of claim 5 , wherein Ris a Cto Calkyl group.7. The composition of claim 4 , wherein the olefin further comprises from about 0.1 mol % to about 26 mol % linear Cto Cmonoolefins.8. The composition of claim 4 , wherein the olefin further comprises from about 0.1 mol % to about 5 mol % Cmonoolefins claim 4 , the Cmonoolefins comprising at least about 95 mol % 1-octene.9. The composition of claim 4 , wherein the olefin comprises i) at least about 70 wt. % ...

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Номер записи: 49
22-03-2018 дата публикации

Novel thiol compound composition for optical material

Номер: US20180079719A1
Автор: Kouhei Takemura, Takashi Aoki
Принадлежит: Mitsubishi Gas Chemical Co Inc

According to the present invention, it is possible to provide a polythiol composition, which comprises a polythiol (A) represented by formula (1) and a thiol compound (B) represented by formula (2). (In formula (1), p and q each independently represent an integer of 1 to 3.) (In formula (2), p and q each independently represent an integer of 1 to 3.)

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Номер записи: 50
23-03-2017 дата публикации

PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS

Номер: US20170081288A1
Автор: CANTURK Belgin, Clark Thomas, Deamicis Carl, GRAY KAITLYN, KANE Elisabeth J., Lorsbach Beth, MUHUHI Joseck M., Roth Gary, Whiteker Gregory, Yang Qiang, Zhang Yu
Принадлежит:

The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds. 45.-. (canceled)8. A process according to claim 7 , wherein Ris C-Chaloalkyl.9. A process according to claim 7 , wherein Ris CHCHCF.10. A process according to claim 7 , wherein Ris CH(2 claim 7 ,2-difluorocyclopropyl).12. A process according to claim 11 , wherein Ris CHCHCF.13. A process according to claim 11 , wherein Ris CH(2 claim 11 ,2-difluorocyclopropyl).14. A process to control insects said process comprising applying a molecule according to to a locus to control insects inhabiting said locus.1519.-. (canceled)22. (canceled) This application claims the benefit of the following U.S. Provisional patent applications: Ser. No. 62/041,943, filed Aug. 26, 2014; Ser. No. 62/001,923, filed May 22, 2014; and Ser. No. 61/892,113, filed Oct. 17, 2013; the entire disclosures of these applications are hereby expressly incorporated by reference into this application.This application relates to efficient and economical synthetic chemical processes for the preparation of pesticidal thioether and pesticidal sulfoxides. Further, the present application relates to certain novel compounds necessary for their synthesis. It would be advantageous to produce pesticidal thioether and pesticidal sulfoxides efficiently and in high yield from commercially available starting materials.The following definitions apply to the terms as used throughout this specification, unless otherwise limited in specific instances.As used herein, the term “alkyl” denotes branched or unbranched hydrocarbon chains.Unless otherwise indicated, the term “cycloalkyl” as employed herein alone is a saturated cyclic hydrocarbon group, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl.The term “thio” as used herein as part of another group refers to a sulfur atom serving as a linker between two groups.The term “halogen” or “halo” as used herein alone or ...

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Номер записи: 51
26-03-2015 дата публикации

SULFONIUM SALT, CHEMICALLY AMPLIFIED RESIST COMPOSITION, AND PATTERN FORMING PROCESS

Номер: US20150086926A1
Автор: FUKUSHIMA Masahiro, KOBAYASHI Tomohiro, OHASHI Masaki, Taniguchi Ryosuke
Принадлежит: SHIN-ETSU CHEMICAL CO., LTD.

A carboxylic acid sulfonium salt having formula (1) is provided wherein Ris hydrogen or a monovalent hydrocarbon group, Rand Rare hydrogen or a monovalent hydrocarbon group, at least one of R, R, and Rhas a cyclic structure, L is a single bond or forms an ester, sulfonate, carbonate or carbamate bond with the vicinal oxygen atom, R, Rand Rare monovalent hydrocarbon groups. The sulfonium salt functions as a quencher in a resist composition, enabling to form a pattern of good profile with minimal LWR, rectangularity, and high resolution. 7. The resist composition of claim 4 , further comprising a nitrogen-containing compound.8. The resist composition of claim 4 , further comprising surfactant which is insoluble in water and soluble in alkaline developer.9. A pattern forming process comprising the steps of applying the chemically amplified resist composition of onto a substrate claim 4 , prebaking to form a resist film claim 4 , exposing the resist film to KrF excimer laser claim 4 , ArF excimer laser or EUV through a photomask claim 4 , baking claim 4 , and developing the exposed resist film in a developer.10. The pattern forming process of wherein the exposing step is by immersion lithography wherein a liquid having a refractive index of at least 1.0 is interposed between the resist film and a projection lens.11. The pattern forming process of claim 10 , further comprising the step of forming a protective film on the resist film claim 10 , and in the immersion lithography claim 10 , the liquid is interposed between the protective film and the projection lens. This non-provisional application claims priority under 35 U.S.C. §119(a) on Patent Application No. 2013-188086 filed in Japan on Sep. 11, 2013, the entire contents of which are hereby incorporated by reference.This invention relates to a carboxylic acid sulfonium salt of specific structure, a chemically amplified resist composition comprising the salt, and a pattern forming process using the resist composition. ...

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Номер записи: 52
29-03-2018 дата публикации

SUBSTITUTED 3-HALOALLYLAMINE INHIBITORS OF SSAO AND USES THEREOF

Номер: US20180086698A1
Автор: Deodhar Mandar, Findlay Alison Dorothy, Foot Jonathan Stuart, Jarolimek Wolfgang, Mcdonald Ian Alexander, Robertson Alan Duncan, Turner Craig Ivan
Принадлежит:

The present invention is related to the preparation and pharmaceutical use of substituted 3-haloallylamine derivatives as SSAO/VAP-1 inhibitors having the structure of Formula I, as defined in the specification: 119-. (canceled)21. The compound of claim 20 , wherein Ris an unsubstituted phenylene group or a phenylene group substituted by one or more groups independently selected from alkyl claim 20 , halo claim 20 , alkoxy and haloalkyl claim 20 , preferably independently selected from methyl claim 20 , fluorine claim 20 , chlorine claim 20 , bromine claim 20 , OCHand CF.22. The compound of claim 20 , wherein X is oxygen.23. The compound of wherein Rand Rare independently selected from the group consisting of hydrogen and Calkyl.28. The compound of wherein said compound is (E)-4-(2-(aminomethyl)-3-fluoroallyloxy)-N-tert-butylbenzamide or (E)-4-(2-(aminomethyl)-3-fluoroallyloxy)-N-tert-butylbenzamide hydrochloride.29. A pharmaceutically acceptable salt of a compound according to .30. The pharmaceutically acceptable salt according to characterized in that it is an acid addition salt.31. The pharmaceutically acceptable salt according to characterized in that the acid addition salt is selected from the group consisting of hydrochlorides claim 30 , hydrobromides claim 30 , sulfates claim 30 , formates claim 30 , acetates claim 30 , lactates claim 30 , malates claim 30 , tartrates claim 30 , citrates claim 30 , ascorbates claim 30 , succinates claim 30 , maleates claim 30 , butyrates claim 30 , valerates and fumarates.32. The pharmaceutically acceptable salt according to characterized in that the acid addition salt is a hydrochloride salt.33. A composition comprising a compound according to claim 20 , or a pharmaceutically acceptable salt claim 20 , and at least one pharmaceutically acceptable excipient claim 20 , carrier or diluent.34. A method of inhibiting the amine oxidase activity of semicarbazide-sensitive amine oxidase/vascular adhesion protein-1 (SSAO/VAP-1) in a ...

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Номер записи: 53
19-03-2020 дата публикации

LINKER COMPOUNDS, METHODS OF PRODUCING THE SAME AND USES THEREOF

Номер: US20200087238A1
Автор: Amir Elizabeth, Anavi Daniel
Принадлежит:

The present disclosure provides a bifunctional linker for coupling at least one functional moiety, preferably a bis-allyl propionic acid (BAPA), to a polymer-containing matrix. Also disclosed by the present disclosure are anhydrides of the bifunctional linker, processes for preparing the bifunctional linker and such anhydride, as well as surfaces, such as cellulose containing matrices, coupled with the bifunctional linker, at times, the latter carrying a functional agent. 2. The process of claim 1 , wherein Rand Reach represent —CH—CH═CH.3. The process of claim 1 , wherein Rrepresents a methyl.4. The process of claim 1 , wherein Xrepresents —O—CH—.5. The process of claim 1 , wherein Xrepresents —O—CH—.6. The process of claim 1 , wherein Rrepresents a carbonyl.7. The process of claim 6 , wherein W represents —OH or —Cl.9. (canceled)10. (canceled)12. (canceled)13. (canceled)15. The process of claim 14 , wherein said Rand Rare identical.16. The process of claim 14 , wherein said leaving group is a halogen.17. The process of claim 14 , wherein said reaction is carried out with a nucleophilic agent having the formula CH═CH—CH—Br.19. (canceled)22. (canceled)23. The process of claim 21 , wherein said amine containing compound is 4-Dimethylaminopyridine (DMAP).24. The process of claim 21 , wherein said polar aprotic solvent is dichloromethane (DCM) and said reaction medium comprises pyridine.25. (canceled)26. A functionalized polymer-containing matrix comprising at least one functional agent bound claim 1 , via a bifunctional linker of formula (I) as defined in claim 1 , where W is an oxygen group linked to the polymer containing matrix.27. (canceled)28. (canceled)29. A modified cellulose-containing matrix comprising covalently bound to its cellulose fibers bis-allyl propionic acid (BAPA) linker; and optionally to at least one functional agent.30. (canceled) The present disclosure relates to bifunctional linkers and their use in matrices functionalization.References ...

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Номер записи: 54
07-04-2016 дата публикации

DIALKYL POLYSULFIDE, PROCESS FOR PREPARING DIALKYL POLYSULFIDE, EXTREME PRESSURE ADDITIVE, AND LUBRICATING FLUID COMPOSITION

Номер: US20160097016A1
Автор: Iba Takafumi, Sakata Hiroshi
Принадлежит: DIC CORPORATION

The present invention provides a dialkyl polysulfide which can be suitably used as an extreme pressure additive that can be added to a lubricant in a wide range of amounts, that enables effective formation of a film of a metal sulfide on a metal surface, and that is less likely to cause corrosion of the metal surface. In particular, provided is a dialkyl polysulfide containing compounds represented by General Formula (1) (where Rand Reach represent an alkyl group, and n is an integer from 1 to 6), wherein the total content of a compound in which n in General Formula (1) is 2 and a compound in which n in General Formula (1) is 3 is in the range of 80 to 100 mass % relative to the entire amount of the compounds represented by General Formula (1). 114-. (canceled)16. The dialkyl polysulfide according to claim 15 , wherein the total content of a compound in which n in General Formula (1) is 2 and a compound in which n in General Formula (1) is 3 is in the range of 85 to 95 mass % relative to the entire amount of the compounds represented by General Formula (1).17. The dialkyl polysulfide according to claim 15 , wherein Rand Reach represent a linear alkyl group having 4 to 20 carbon atoms.18. The dialkyl polysulfide according to claim 15 , wherein the first process includes allowing the 1-olefin compound (a) having a linear end to react with sulfur in the presence of a hydrogen sulfide at 60 to 130° C. and then holding a reaction system at 160 to 200° C. for 5 to 48 hours to obtain the dialkyl polysulfide (A).19. A method for producing a dialkyl polysulfide claim 15 , the method comprising a first process in which a 1-olefin compound (a) having a linear end is allowed to react with sulfur in the presence of a hydrogen sulfide to obtain a dialkyl polysulfide (A) and a second process in which the dialkyl polysulfide compound (A) is allowed to react with a sulfide of an alkali metal to reduce the number of sulfur atoms contained in the dialkyl polysulfide (A).20. The method ...

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Номер записи: 55
09-04-2015 дата публикации

COMPOUNDS AS L-CYSTINE CRYSTALLIZATION INHIBITORS AND USES THEREOF

Номер: US20150099806A1
Автор: Ward Michael D., Zhu Zina
Принадлежит:

A method of preventing or inhibiting L-cystine crystallization is disclosed, using the compounds of formula I: 2. (canceled)3. (canceled)4. (canceled)5. (canceled)6. (canceled)7. (canceled)8. A method according to wherein the compound is of formula I; the subscript m is 0; the subscript v is 0; and the compound is according to formula II:{'br': None, 'sup': 1a', '1b, 'R-A-R\u2003\u2003II;'}{'sup': 1a', '1b, 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'and wherein A, Rand Rare as in .'}10. (canceled)11. (canceled)12. (canceled)13. (canceled)14. (canceled)15. (canceled)16. (canceled)17. (canceled)18. (canceled)19. (canceled)20. (canceled)21. (canceled)22. (canceled)23. (canceled)24. (canceled)25. (canceled)26. (canceled)27. (canceled)28. (canceled)29. (canceled)30. (canceled)31. (canceled)32. (canceled)33. (canceled)34. (canceled)35. (canceled)36. (canceled)37. (canceled)38. (canceled)39. (canceled)40. (canceled)41. (canceled)42. (canceled)43. (canceled)44. (canceled)46. (canceled)47. (canceled)48. (canceled)49. (canceled)50. (canceled)51. The method of claim 1 , wherein one of Rand Ris H; and the other is alkyl or aryl.52. The method of claim 1 , wherein one of Rand Ris H; and the other is Me claim 1 , Et claim 1 , n-Pr claim 1 , i-Pr claim 1 , n-Bu claim 1 , t-Bu claim 1 , or Ph.53. (canceled)54. (canceled)55. (canceled)56. (canceled)57. (canceled)58. (canceled)59. The method of claim 1 , wherein each of Rand Ris alkyl claim 1 , cycloalkyl claim 1 , or aryl.60. The method of claim 1 , wherein each of Rand Ris independently Me claim 1 , Et claim 1 , n-Pr claim 1 , i-Pr claim 1 , n-Bu claim 1 , t-Bu claim 1 , cyclohexyl claim 1 , cyclopropyl claim 1 , or Ph.61. The method of claim 1 , wherein each of Rand Ris alkenyl.62. The method of claim 1 , wherein each of Rand Ris alkynyl.63. (canceled)64. (canceled)65. (canceled)66. (canceled)67. (canceled)68. The method of claim 1 , wherein each of Rand Ris Ph.70. (canceled)71. (canceled)72. (canceled)73. (canceled)74. ( ...

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Номер записи: 56
09-04-2015 дата публикации

Aryloxyurea compound and pest control agent

Номер: US20150099883A1
Автор: Asaho Nagagata, Daisuke Hanai, Hironori Furukawa, Jun Kanazawa, KATSUNORI Tanaka, Tetsuo Tamai
Принадлежит: Nippon Soda Co Ltd

The present invention provides an aryloxyurea compound or salt thereof, and a pest control agent including the aryloxyurea compound or salt thereof as an active ingredient. The aryloxyurea compound has a superior acaricidal and/or insecticidal activity, superior safety, and can be synthesized advantageously and industrially. The compound of the present invention includes aryloxyurea compounds represented by the following formula or salts thereof: in the formula, Cy represents an unsubstituted or X-substituted phenyl group or the like, X represents a halogen atom or the like, R 1 represents an ethyl group or the like, R 2 represents a hydrogen atom or the like, R 3 and R 4 represents a methyl group or the like, X 1 represents a methylthio group or the like, m1 represents an integer of 1 to 4, X 2 represents a methyl group or the like, m2 is an integer of 0 to 3.

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Номер записи: 57
28-03-2019 дата публикации

FUSING AGENT INCLUDING A METAL BIS(DITHIOLENE) COMPLEX

Номер: US20190092799A1
Автор: Erickson Kristopher J., Hartman Aja, Olubummo Paul, Tom Howard S., Zhao Lihua
Принадлежит: Hewlett-Packard Development Company, L.P.

An example of a fusing agent includes a metal bis(dithiolene) complex, a thiol surfactant, a polar aprotic solvent, and a balance of water. In an example of a method of making the fusing agent, the metal bis(dithiolene) complex is exposed to an aqueous solution including a reducing agent and a thiol surfactant to form a reduced metal bis(dithiolene) complex and to dissolve the reduced metal bis(dithiolene) complex in the aqueous solution. The aqueous solution is incorporated into a vehicle including a water soluble organic solvent and an additive selected from the group consisting of an emulsifier, a surface tension reduction agent, a wetting agent, a scale inhibitor, an anti-deceleration agent, a chelating agent, an antimicrobial agent, and a combination thereof. The fusing agent may be utilized in a three-dimensional printing method and/or incorporated into a three-dimensional printing system. 1. A fusing agent , comprising:a metal bis(dithiolene) complex;a thiol surfactant;a polar aprotic solvent; anda balance of water.3. The fusing agent as defined in wherein:the polar aprotic solvent is selected from the group consisting of 1-methyl-2-pyrrolidone, 2-pyrrolidone, 1-(2-hydroxyethyl)-2-pyrrolidone, dimethylformamide (DMF), dimethyl sulfoxide (DMSO), and a combination thereof; andthe thiol surfactant is dodecanethiol.4. The fusing agent as defined in claim 1 , further comprising a colorant.5. The fusing agent as defined in claim 1 , further comprising an additive selected from the group consisting of a water soluble organic solvent claim 1 , an emulsifier claim 1 , a surface tension reduction agent claim 1 , a wetting agent claim 1 , a scale inhibitor claim 1 , an anti-deceleration agent claim 1 , a chelating agent claim 1 , an antimicrobial agent claim 1 , and a combination thereof.6. The fusing agent as defined in wherein:the metal bis(dithiolene) complex is present in an amount ranging from about 1 wt % to about 3 wt % based on a total wt % of the fusing agent; ...

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Номер записи: 58
06-04-2017 дата публикации

RESIST COMPOSITION, METHOD OF FORMING RESIST PATTERN, COMPOUND, AND ACID DIFFUSION CONTROL AGENT

Номер: US20170097564A1
Автор: Endo Kotaro, Nagamine Takashi, Nito Hideto
Принадлежит: TOKYO OHKA KOGYO CO., LTD.

A resist composition which generates acid upon exposure and exhibits changed solubility in a developing solution under action of acid, the resist composition including a base component (A) which exhibits changed solubility in a developing solution under action of acid, and a compound (D1) represented by general formula (d1), wherein Z represents an anion having an aromatic ring containing a hydroxybenzoic acid skeleton, provided that at least one hydrogen atom of the aromatic ring has been substituted with a halogen atom; m represents an integer of 1 or more; and M represents an organic cation having a valency of m. 1. A resist composition which generates acid upon exposure and exhibits changed solubility in a developing solution under action of acid , the resist composition including a base component (A) which exhibits changed solubility in a developing solution under action of acid , and a compound (D1) represented by general formula (d1) shown below:{'br': None, 'i': Z', 'M, 'sup': −', 'm+, 'sub': '1/m', '()\u2003\u2003(d1)'}{'sup': −', 'm+, 'wherein Z represents an anion having an aromatic ring containing a hydroxybenzoic acid skeleton, provided that at least one hydrogen atom of the aromatic ring has been substituted with a halogen atom; m represents an integer of 1 or more; and Mrepresents an organic cation having a valency of m.'}2. The resist composition according to claim 1 , wherein the acid dissociation constant pKa of the conjugate acid of the compound (D1) is less than 3.3. The resist composition according to claim 1 , wherein the octanol/water partition coefficient (log P) of the compound (D1) is 1.5 or more.5. The resist composition according to claim 4 , wherein Rh represents a fluorine atom.7. The resist composition according to claim 6 , wherein Rh represents a fluorine atom.8. The resist composition according to claim 1 , further comprising an acid generator component (B) which generates acid upon exposure claim 1 , provided that the acid ...

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Номер записи: 59
04-04-2019 дата публикации

NANO-TO-NANO FE/PPM Pd CATALYSIS OF CROSS-COUPLING REACTIONS IN WATER

Номер: US20190099747A1
Автор: Handa Sachin, Lipshutz Bruce H.
Принадлежит:

In one embodiment, the present application discloses a catalyst composition comprising: a) a reaction solvent or a reaction medium; b) organometallic nanoparticles comprising: i) a nanoparticle (NP) catalyst, prepared by a reduction of an iron salt in an organic solvent, wherein the catalyst comprises at least one other metal selected from the group consisting of Pd, Pt, Au, Ni, Co, Cu, Mn, Rh, Ir, Ru and Os or mixtures thereof; c) a ligand; and d) a surfactant; wherein the metal or mixtures thereof is present in less than or equal to 50,000 ppm relative to the iron salt. 120.-. (canceled)22. The method of claim 21 , wherein the metal claim 21 , other than Pd claim 21 , is selected from the group consisting of Pt claim 21 , Au claim 21 , Ni claim 21 , Co claim 21 , Cu claim 21 , Mn claim 21 , Rh claim 21 , Ir claim 21 , Ru and Os or a mixture thereof.23. The method of further comprising:iii) contacting the product mixture with an organic solvent to form an organic phase and an aqueous phase; andiv) separating the organic phase from the aqueous phase containing the micelle composition as well as the iron/ppm Pd nanoparticles.24. The method of further comprising:v) re-cycling the aqueous phase containing the micelle composition and Fe/ppm Pd nanoparticles for use in a subsequent cross coupling or other reactions.25. The method of claim 21 , wherein the reaction solvent is water claim 21 , and the reaction solvent further comprising an organic solvent claim 21 , wherein the organic co-solvent is present in at least 5% claim 21 , 10% claim 21 , 20% claim 21 , 30% claim 21 , 40% claim 21 , 50% claim 21 , 70% claim 21 , 80% or at least 90% wt/wt.2611. The method of claim claim 21 , wherein the organic co-solvent is present at a wt of organic co-solvent to the wt of water (wt/wt) of 1/10 claim 21 , 2/10 claim 21 , 5/10 claim 21 , 10/10 claim 21 , 20/10 claim 21 , 30/10 claim 21 , 50/10 claim 21 , 70/10 claim 21 , 90/10 claim 21 , 100/10 claim 21 , 200/10 claim 21 , 300/10 ...

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Номер записи: 60
21-04-2016 дата публикации

CYCLOALKYL ACID DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL APPLICATION THEREOF

Номер: US20160108035A1
Автор: CAO Guoqing, Dong Qing, GU Chunyan, HAN Chunzhou, HU Qiyue, JIN Fangfang, LAN Jiong, LI Xiaotao, LIU Bonian, PENG Jianbiao, Sun Piaoyang
Принадлежит: Shanghai Hengrui Pharmaceutical Co., Lt.d

Cycloalkyl acid derivatives, a preparation method thereof, and a pharmaceutical application thereof are described. In particular, a cycloalkyl acid derivative represented by general formula (I) and a medical salt thereof, a preparation method thereof, and an application of the cycloalkyl acid derivative and the medical salt thereof as URAT1 inhibitors, and particularly as therapeutic agents for diseases related to an abnormal uric acid level are described, wherein definitions of substituent groups in general formula (I) are the same as the definitions in the specification. 2. The compound of formula (I) claim 1 , or the tautomer claim 1 , mesomer claim 1 , racemate claim 1 , enantiomer claim 1 , or diastereomer thereof claim 1 , or mixture thereof claim 1 , or the pharmaceutically acceptable salt thereof according to claim 1 , wherein ring A is cycloalkyl.3. The compound of formula (I) claim 1 , or the tautomer claim 1 , mesomer claim 1 , racemate claim 1 , enantiomer claim 1 , or diastereomer thereof claim 1 , or mixture thereof claim 1 , or the pharmaceutically acceptable salt thereof according to claim 1 , wherein Ris selected from the group consisting of hydrogen claim 1 , halogen claim 1 , cyano claim 1 , alkyl claim 1 , cycloalkyl claim 1 , aryl claim 1 , —OR claim 1 , —NRRand —NRC(O)R claim 1 , wherein the alkyl claim 1 , cycloalkyl and aryl are each independently optionally substituted with one or more groups selected from the group consisting of halogen claim 1 , cyano claim 1 , nitro claim 1 , oxo claim 1 , alkyl claim 1 , haloalkyl claim 1 , hydroxyalkyl claim 1 , cycloalkyl and heterocyclyl.4. The compound of formula (I) claim 1 , or the tautomer claim 1 , mesomer claim 1 , racemate claim 1 , enantiomer claim 1 , or diastereomer thereof claim 1 , or mixture thereof claim 1 , or the pharmaceutically acceptable salt thereof according to claim 1 , wherein Ris selected from the group consisting of hydrogen claim 1 , halogen claim 1 , alkyl and haloalkyl.5. ...

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Номер записи: 61
19-04-2018 дата публикации

GLUTATHIONE-CLEAVABLE PRODRUG AND METHODS OF USE THEREOF

Номер: US20180105505A1
Автор: Brown Milton L., Hou Shujie, Kong Yali, Smith Jacqueline, Wang Kan
Принадлежит: GEORGETOWN UNIVERSITY

A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject. 2. A composition comprising a compound of and a pharmaceutically acceptable carrier.3. A kit comprising a compound of .4. A method of treating or preventing cancer in a subject claim 1 , comprising administering to the subject an effective amount of a compound of .5. The method of claim 4 , wherein the cancer is breast cancer.6. The method of claim 5 , wherein the breast cancer is triple negative breast cancer.7. A method of inhibiting angiogenesis in a subject claim 1 , comprising administering to the subject an effective amount of a compound of .8. The method of claim 7 , wherein the subject has cancer.9. The method of claim 8 , wherein the cancer is triple negative breast cancer.10. The method of claim 7 , wherein the cancer overexpresses glutathione.11. A method of inhibiting tubulin polymerization in a cell claim 1 , comprising contacting the cell with an effective amount of a compound of .12. The method of claim 11 , wherein the cell is a cancer cell.13. The method of claim 12 , wherein the cancer cell is a triple negative breast cancer cell.14. The method of claim 11 , wherein the cell is a cell that overexpresses glutathione.15. A method of delivering combretastatin A-4 to a cell claim 1 , comprising contacting a cell comprising glutathione with a compound of claim 1 , wherein the glutathione cleaves the compound to form combretastatin A-4.16. The method of claim 15 , wherein the cell is a cancer cell.17. The method of claim 16 , wherein the cancer cell is a triple negative breast cancer cell.18. The method of claim 15 , wherein the cell is a cell that overexpresses glutathione.19. ...

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Номер записи: 62
19-04-2018 дата публикации

Mixed Decyl Mercaptans Compositions and Use Thereof as Chain Transfer Agents

Номер: US20180105623A1
Автор: KREIDER Jason L., Matson Michael S.
Принадлежит:

A chain transfer agent composition comprises at least one branched Cmercaptan selected from 5-methyl-1-mercapto-nonane, 3-propyl-1-mercapto-heptane, 4-ethyl-1-mercapto-octane, 2-butyl-1-mercapto-hexane, 5-methyl-2-mercapto-nonane, 3-propyl-2-mercapto-heptane, 4-ethyl-2-mercapto-octane, 5-methyl-5-mercapto-nonane, or combinations thereof. The chain transfer agent composition can be a component of an emulsion polymerization mixture and can be used in a process for emulsion polymerization for the production of polymers, for example, via free-radical polymerization. 3. The composition of claim 2 , wherein the olefin comprises a) at least 76 mol % Cmonoolefins claim 2 , the Cmonoolefins comprising i) at least 3 mol % 2-butyl-1-hexene (represented by Structure L) claim 2 , ii) at least 8 mol % 3-propyl-1-heptene (represented by Structure J) claim 2 , iii) at least 6 mol % 4-ethyl-1-octene (represented by Structure K) claim 2 , and iv) at least 20 mol % 5-methyl-1-nonene (represented by Structure I); and b) at least 1 mol % Cmonoolefins.4. The composition of claim 3 , wherein the Cmonoolefins comprise from 1 mol % to 16 mol % 4-decene and/or 5-decene.5. The composition of claim 3 , wherein the Cmonoolefins comprise from 0.5 mol % to 9 mol % 1-decene.6. The composition of claim 2 , wherein the olefin further comprises from 0.1 mol % to 5 mol % Cmonoolefins claim 2 , the Cmonoolefins comprising from 54 mol % to 74 mol % 1-dodecene.7. The composition of claim 2 , wherein the olefin further comprises from 0.1 mol % to 5 mol % Cmonoolefins claim 2 , the Cmonoolefins comprising at least 95 mol % 1-octene.8. The composition of claim 1 , wherein the olefin further comprises from 0.05 mol % to 2 mol % Cmonoolefins and/or Cmonoolefins.9. The composition of claim 1 , wherein the chain transfer agent composition has an odor which is less unpleasant than an odor of mercaptan compounds which include n-dodecyl mercaptans claim 1 , tert-dodecyl mercaptans claim 1 , or combinations thereof ...

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Номер записи: 63
29-04-2021 дата публикации

IRON AMINO ACID COMPOUNDS, METHOD FOR PREPARING IRON AMINO ACID COMPOUNDS, COMPOSITIONS CONTAINING IRON AMINO ACID COMPOUNDS, AND USES THEREOF

Номер: US20210122705A1
Автор: FERNANDES FILHO Nelson Henriques, Fernandes Nelson Henriques, SERCHELI Ricardo Da Silva
Принадлежит:

The invention describes hydrosoluble iron (III) oxyhydroxide complexes prepared from different sources of iron, amino acids and carboxylic acids. The iron (III) complexes have no undesirable residual taste and can be used as supplementation forms for the prevention or treatment of iron deficiency anemia in humans or animals and pharmaceutical or food compositions containing them. 3. Process for obtaining iron amino acid compounds , comprising:(i) reaction of a source of iron (III) with an amino acid, an organic acid and a base in aqueous solution;(ii) separating the iron (III) amino acid complex obtained in solid form or as an aqueous solution; and(iii) drying the solvent used for obtaining the iron (III) amino acid complex.4. Process according to claim 3 , wherein the stoichiometric ratio between the iron source and the selected amino acid is not less than 1:0.5 claim 3 , and preferably not greater than 1:10 claim 3 , respectively claim 3 , the stoichiometric ratio between the iron source and the selected organic acid varied between 1:0.1 and 1:1 and the stoichiometric ratio of the iron source and the base varied from 1:0.001 and 1:5.0.5. Process according to claim 3 , wherein the iron source is selected from ferric hypophosphite claim 3 , ferric albuminate claim 3 , ferric chloride claim 3 , ferrous chloride claim 3 , ferric sulfate claim 3 , ferrous sulfate claim 3 , ammonium ferric sulfate claim 3 , ammonium ferrous sulfate claim 3 , ferric citrate claim 3 , ammonium ferric citrate claim 3 , ferrous gluconate claim 3 , ferrous iodide claim 3 , ferrous lactate claim 3 , ferrous fumarate claim 3 , ferric triglycinate claim 3 , ferrous bisglycinate claim 3 , ferrous aspartate glycinate claim 3 , ferric nitrate claim 3 , ferric aspartate claim 3 , ferric phosphate claim 3 , ferrous hydroxide claim 3 , ferric hydroxide claim 3 , ferrous oxide claim 3 , ferric oxide claim 3 , metallic iron claim 3 , ferric ascorbate claim 3 , ferrous formate claim 3 , ferrous acetate ...

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Номер записи: 64
29-04-2021 дата публикации

METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES

Номер: US20210122768A1
Автор: Reardon Michael, Silva Richard A.
Принадлежит:

The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors. 136-. (canceled)38. The method of claim 37 , wherein claim 37 , in step 1) claim 37 , 0.6 to 1.0 molar equivalent of cyanuric chloride relative to the compound of formula (IA′) is used.39. The method of claim 38 , wherein between 0.7 and 0.8 molar equivalent of cyanuric chloride is used.40. The method of claim 38 , wherein 0.75 molar equivalent or 0.85 molar equivalent of cyanuric chloride is used.41. The method of claim 37 , wherein the reaction in step 1) is carried out in DMF.42. The method of claim 37 , wherein claim 37 , in step 2) claim 37 , the reaction between the compound of formula (IIA′) and the compound of formula (b) is carried out in the presence of an alcohol activating agent and an azodicarboxylate.43. The method of claim 42 , wherein the alcohol activating agent is tributylphosphine or triphenylphosphine claim 42 , and the azodicarboxylate is selected from the group consisting of diethyl azodicarboxylate (DEAD) claim 42 , diisopropyl azodicarboxylate (DIAD) claim 42 , 1 claim 42 ,1′-(azodicarbonyl)dipiperidine (ADDP) claim 42 , and ditertbutyl azodicarboxylate (DTAD).44. The method of claim 43 , wherein the alcohol activating agent is triphenylphosphine and the azodicarboxylate is diisopropyl azodicarboxylate (DIAD).45. The method of claim 44 , wherein the triphenylphosphine and diisopropyl azodicarboxylate are mixed together first to form an triphenylphosiphosphine-azodicarboxylate complex before mixing the complex with the compound of formula (IIA′) and the compound of formula (b).46. The method of claim 37 , wherein claim 37 , in step 3) claim 37 , the imine reducing agent is selected from the group consisting of sodium borohydride claim 37 , sodium triacetoxy borohydride claim 37 , sodium cyanoborohydride claim 37 , lithium aluminum hydride claim 37 , hydrogen gas claim 37 , ammonium formate claim 37 , borane claim 37 , ...

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Номер записи: 65
11-04-2019 дата публикации

Methods for Producing Thiol Compounds and Sulfide Compounds Using Diphenylamine or a Phenol Compound

Номер: US20190106384A1
Автор: LASSEN Kenneth M.
Принадлежит:

The present invention discloses processes for producing a thiol compound or a sulfide compound from an olefin compound. Diphenylamine or a phenol compound can be used to increase the rate of conversion of the olefin compound to the thiol compound or the sulfide compound. 1. A process for producing a thiol compound , the process comprising: a) an olefin compound;', {'sub': '2', 'b) HS;'}, 'c) diphenylamine and/or a phenol compound, or any combination thereof and', 'd) a photoinitiator and/or a free radical initiator; and, 'i) contactingii) forming the thiol compound.2. The process of claim 1 , wherein the phenol is an alkyl phenol.3. The process of claim 1 , wherein a molar ratio of HS to carbon-carbon double bonds of the olefin compound is from about 2:1 to about 150:1.4. The process of claim 1 , wherein:an amount of diphenylamine and/or the phenol compound is in a range from about 0.1 wt. % to about 1 wt. %, based on the weight of the olefin compound; andan amount of the photoinitiator and/or the free radical initiator is in a range from about 0.05 wt. % to about 5 wt. %, based on the weight of the olefin compound.5. The process of claim 1 , wherein the thiol compound is formed in the presence of ultraviolet light.6. The process of claim 1 , wherein the olefin compound comprises ethylene claim 1 , propylene claim 1 , 1-butene claim 1 , 2-butene claim 1 , 3-methyl-1-butene claim 1 , isobutylene claim 1 , 1-pentene claim 1 , 2-pentene claim 1 , 3-methyl-1-pentene claim 1 , 4-methyl-1-pentene claim 1 , 1-hexene claim 1 , 2-hexene claim 1 , 3-ethyl-1-hexene claim 1 , 1-heptene claim 1 , 2-heptene claim 1 , 3-heptene claim 1 , 1-octene claim 1 , 1-decene claim 1 , 1-dodecene claim 1 , styrene claim 1 , cyclopentene claim 1 , cyclohexene claim 1 , cycloheptene claim 1 , cyclooctene claim 1 , or any combination thereof.7. The process of claim 1 , wherein the olefin compound comprises limonene claim 1 , butadiene claim 1 , isoprene claim 1 , cyclobutadiene claim 1 , ...

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Номер записи: 66
26-04-2018 дата публикации

URETHANE-MODIFIED PREPOLYMERS CONTAINING PENDENT ALKYL GROUPS, COMPOSITIONS AND USES THEREOF

Номер: US20180112025A1
Автор: BOGHOSSIAN RAZMIK, Sharaby Ahmed
Принадлежит:

Adducts and prepolymers comprising pendent alkyl groups are disclosed. Polythiol adducts prepared by reacting a polythiol with a ketone and urethane-extended polythiol adducts. The polythiol adducts can be terminated with isocyanate groups. Compositions comprising the isocyanate-terminated polythiol adducts, isocyanate-terminated sulfur-containing prepolymers, and diisocyanates can be combined with polyamine or polyepoxide curing agents to provide curable compositions. Cured compositions are suitable for aerospace coating and sealant applications. The compositions can also include a low specific gravity filler and, when cured, meet the requirements of aerospace sealant applications. 1. A polythiol adduct comprising the condensation reaction products of reactants comprising:a polythiol; anda ketone.2. The polythiol adduct of claim 1 , wherein the polythiol adduct has a thiol functionality from 2 to 6.3. The polythiol adduct of claim 1 , wherein the polythiol comprises a dithiol claim 1 , wherein the dithiol comprises dimercaptodiethylsulfide (DMDS) claim 1 , 3 claim 1 ,6-dioxa-1 claim 1 ,8-octanedithiol (DMDO) claim 1 , or a combination thereof.4. The polythiol adduct of claim 1 , wherein the ketone comprises propan-2-one claim 1 , methyl ethyl ketone (butan-2-one) claim 1 , pentan-2-one claim 1 , hexan-2-one claim 1 , pentan-3-one claim 1 , 3-methylbutan-2-one claim 1 , 3-methylpentan-2-one claim 1 , 4-methylhexan-3-one claim 1 , 2-methylpentan-3-one claim 1 , 2 claim 1 ,4-dimethylpentan-3-one claim 1 , or a combination thereof.5. The polythiol adduct of claim 1 , wherein:the polythiol comprises dimercaptodiethylsulfide, 3,6-dioxa-1,8-octanedithiol, or a combination thereof; andthe ketone comprises methyl ethyl ketone.6. The polythiol adduct of claim 1 , wherein claim 1 , {'br': None, 'sup': 3', '3, 'sub': p', 'q', 'r, 'HS—[—(CHR)—X—]—(CHR)—SH\u2003\u2003(1)'}, 'the polythiol comprises a dithiol having the structure of Formula (1) [{'sup': '3', 'each Ris selected ...

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Номер записи: 67
28-04-2016 дата публикации

COMPOUND, ACTIVE LIGHT SENSITIVE OR RADIATION SENSITIVE RESIN COMPOSITION, RESIST FILM USING SAME, RESIST-COATED MASK BLANK, PHOTOMASK, PATTERN FORMING METHOD, METHOD FOR MANUFACTURING ELECTRONIC DEVICE, AND ELECTRONIC DEVICE

Номер: US20160116840A1
Автор: Tsuchimura Tomotaka
Принадлежит: FUJIFILM Corporation

Provided is an active light sensitive or radiation sensitive resin composition which contains a compound (A) represented by General Formula (I) or (II): 2. The active light sensitive or radiation sensitive resin composition according to claim 1 ,{'sub': 1', '2, 'sup': '1', 'wherein, in General Formula (I) or (II), Xor Xis a group which is represented by —NH— or —NR—.'}3. The active light sensitive or radiation sensitive resin composition according to claim 1 ,{'sub': 2', '2, 'wherein, in General Formula (I) or (II), Xor Xis a group which is represented by —S—.'}4. The active light sensitive or radiation sensitive resin composition according to claim 1 ,{'sub': 1', '2, 'wherein, in General Formula (I) or (II), Yor Yis an aryl group or a monovalent hydrocarbon group which has an alicyclic hydrocarbon structure having 5 or more carbon atoms.'}5. The active light sensitive or radiation sensitive resin composition according to claim 1 , further comprising:a compound (B) which has a phenolic hydroxyl group.8. The active light sensitive or radiation sensitive resin composition according to claim 1 , further comprising:an acid cross-linkable compound (C).9. The active light sensitive or radiation sensitive resin composition according to claim 8 ,wherein the compound (C) is a compound which has two or more hydroxymethyl groups or alkoxymethyl groups in a molecule.10. The active light sensitive or radiation sensitive resin composition according to claim 1 , which is used for exposure to electron beams or extreme ultraviolet light.11. A resist film formed using the active light sensitive or radiation sensitive resin composition according to .12. A resist-coated mask blank coated with the resist film according to .13. A photomask obtained by exposing and developing the resist-coated mask blank according to .14. A pattern forming method comprising:{'claim-ref': {'@idref': 'CLM-00011', 'claim 11'}, 'exposing the resist film according to ; and'}developing the exposed film.15. A ...

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Номер записи: 68
13-05-2021 дата публикации

Dynamic combinatorial library based on pseudopeptides and its use for the detection of cysteine and other biothiols

Номер: US20210139419A1
Автор: Igancio ALFONSO RODRIGUEZ, Jordi Sola Oller, Maria LAFUENTE FABRA
Принадлежит: Consejo Superior de Investigaciones Cientificas CSIC

The present invention relates to a dynamic chemical network that mimics the transfer of information and ultimately produces a chemical response, for example a readable signal. More specifically, the invention discloses a dynamic system able to selectively sense a biologically-relevant analyte, such as cysteine, in its reduced or its oxidized form (cystine) in aqueous media and in a biofluid (such as urine) for diagnostic application. Due to this property, said dynamic system is useful for the detection of cysteine or its derivatives in biological fluids such as urine.

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Номер записи: 69
09-04-2020 дата публикации

SULFUR DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS

Номер: US20200109110A1
Автор: Beard Richard L., Donello John E., Garst Michael E., Liu Xiaoxia, Viswanath Veena, Yuan Haiqing
Принадлежит:

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors. 115.-. (canceled)17. The method according to claim 16 , wherein:{'sup': '5', 'Ris —S—.'}18. The method according to claim 16 , wherein:{'sup': '5', 'Ris —S(O)—.'}19. The method according to claim 16 , wherein:{'sup': '5', 'sub': '2', 'Ris —S(O)—.'}20. The method according to claim 16 , wherein the compound is selected from the group consisting of:3,4-dichloro-N-[5-chloro-2-(methylthio)phenyl]benzenesulfonamide;3,4-dichloro-N-[5-chloro-2-(methylsulfinyl)phenyl]benzenesulfonamide;4-chloro-N-[5-chloro-2-(methylsulfinyl)phenyl]-3-methylbenzenesulfonamide;N-[5-chloro-2-(methylsulfinyl)phenyl]-3-nitro-4-(trifluoromethyl)benzenesulfonamide;4-chloro-N-[5-chloro-2-(methylthio)phenyl]-2-fluorobenzenesulfonamide;4-chloro-N-{5-chloro-2-[(1H-imidazol-4-ylmethyl)sulfonyl]phenyl}-3-(trifluoromethyl)benzenesulfonamide;4-chloro-N-[5-chloro-2-(methylsulfinyl)phenyl]-3-(trifluoromethyl)benzenesulfonamide;4-chloro-N-[5-chloro-2-(ethylthio)phenyl]-3-(trifluoromethyl)benzenesulfonamide;4-chloro-N-[5-chloro-2-(ethylsulfinyl)phenyl]-3-(trifluoromethyl)benzenesulfonamide;tert-butyl {6-[({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}thio)methyl]pyridin-2-yl}carbamate;tert-butyl {6-[({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}sulfonyl)methyl]pyridin-2-yl}carbamate;tert-butyl 3-[({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}thio)methyl]-1H-pyrazole-1-carboxylate;3-{[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]sulfinyl}-N,N-dimethylpropanamide;3-{[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]sulfonyl}-N,N-dimethylpropanamide;3-[(4-chloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)thio]-N,N-dimethylpropanamide;3-[(4-chloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)sulfinyl]-N,N-dimethylpropanamide;3-[(4-chloro-2 ...

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Номер записи: 70
09-04-2020 дата публикации

Synthesis of Methyl Ethyl Sulfide and Related Production Systems

Номер: US20200109111A1
Автор: Daniel M. Hasenberg, Henry HWU, Jason L. Kreider, Kenneth M. Lassen
Принадлежит: Chevron Phillips Chemical Co LP

The present invention discloses processes for producing methyl ethyl sulfide by contacting dimethyl sulfide and diethyl sulfide in the presence of a suitable catalyst. Methyl ethyl sulfide can be used as an odorant in natural gas. Integrated mercaptan and sulfide manufacturing systems and integrated methods for making mercaptans and sulfides also are disclosed.

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Номер записи: 71
13-05-2021 дата публикации

TIN ALLOY PLATING SOLUTION

Номер: US20210140060A1
Автор: Tatsumi Koji
Принадлежит: MITSUBISHI MATERIALS CORPORATION

A tin alloy plating solution includes a soluble tin salt, a soluble salt of a metal more noble than tin, and a sulfide compound represented by General Formula (1). In the General Formula (1), (A) is a hydrocarbon group including no oxygen atom and having 1 to 2 carbon atoms, or (A) is a hydrocarbon group including one or more oxygen atoms and having 2 to 6 carbon atoms. The metal which is more noble than tin is preferably silver, copper, gold or bismuth. 1. (canceled)2. (canceled)4. The tin alloy plating solution according to claim 3 ,wherein the metal which is more noble than tin is at least one or more metals selected from silver, copper, gold, and bismuth.5. The tin alloy plating solution according to claim 3 , further comprising at least one or more types of auxiliary complexing agent selected from a gluconic acid or a salt thereof claim 3 , a citric acid or a salt thereof claim 3 , a pyrophosphoric acid or a salt thereof claim 3 , an ethylenediamine claim 3 , a thiourea claim 3 , a mercaptothiazole claim 3 , a mercaptotriazole claim 3 , a mercaptotetrazole claim 3 , and a hydroxyalkylphosphine.6. The tin alloy plating solution according to claim 3 , further comprising at least one or more types of surfactant selected from an anionic surfactant claim 3 , a cationic surfactant claim 3 , a non-ionic surfactant claim 3 , and an amphoteric surfactant.7. The tin alloy plating solution according to claim 3 , further comprising an antioxidant.8. The tin alloy plating solution according to claim 3 , further comprising a complexing agent for tin.9. The tin alloy plating solution according to claim 3 , further comprising a pH adjusting agent.10. The tin alloy plating solution according to claim 3 , further comprising a brightening agent.11. The tin alloy plating solution according to claim 4 , further comprising at least one or more types of auxiliary complexing agent selected from a gluconic acid or a salt thereof claim 4 , a citric acid or a salt thereof claim 4 , a ...

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Номер записи: 72
03-05-2018 дата публикации

A PROCESS FOR THE PREPARTION OF METHIONINE ALPHA-HYDROXY ANALOGUES FROM SUGARS AND DERIVATIVES THEREOF

Номер: US20180118673A1
Автор: Sadaba Zubiri Irantzu, TAARNING Esben, Tzoulaki Despina
Принадлежит: Haldor Topsoe A/S

A process for the preparation of methionine α-hydroxy analogue and derivatives thereof comprising contacting one or more sugars or derivatives thereof with a metallo-silicate composition in the presence of a compound comprising sulphur and a solvent. 1. A process for the preparation of a methionine α-hydroxy analogue and derivatives thereof of the formula:{'br': None, 'R′—S—CH2-CH2-CHOH—COO—R \u2003\u2003(I)'}{'sub': 1', '8, 'wherein R is selected from the group consisting of H, C-Calkyl, alkaline or alkaline-earth metals; and R′ is selected from the group consisting of H and methyl; and wherein the process comprises a step of contacting one or more sugars or derivatives thereof with a metallo-silicate composition in the presence of a compound comprising sulphur and a solvent.'}2. A process according to claim 1 , wherein the compound comprising sulphur is selected from the group consisting of C-Calkyl thiol claim 1 , C-Calkyl thiol salt claim 1 , dimethylmercaptan claim 1 , dimethyl disulphide and hydrogen sulphide.3. A process according to claim 2 , wherein the compound comprising sulphur is selected from the group consisting of methane thiol claim 2 , methanethiolate alkaline salts claim 2 , dimethylmercaptan claim 2 , dimethyl disulphide claim 2 , and hydrogen sulphide.4. A process according to claim 1 , wherein the one or more sugars or derivatives thereof is selected from the group consisting of glucose claim 1 , fructose claim 1 , galactose claim 1 , mannose claim 1 , sucrose claim 1 , xylose claim 1 , erythrose claim 1 , erythrulose claim 1 , threose claim 1 , glycolaldehyde claim 1 , methyl vinyl glycolate claim 1 , vinyl glycolic acid and 2-hydroxy-γ-butyrolactone.5. A process according to claim 1 , wherein the one or more sugars or derivatives thereof are derivatives obtained by subjecting one or more sugars selected from the group consisting of glucose claim 1 , fructose claim 1 , galactose claim 1 , mannose claim 1 , sucrose claim 1 , xylose claim 1 , ...

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Номер записи: 73
05-05-2016 дата публикации

Photoacid generators and photoresists comprising same

Номер: US20160124304A1
Автор: Cheng-Bai Xu, Cong Liu, Emad Aqad, George G. Barclay, Joseph Mattia, Mingqi Li
Принадлежит: Rohm and Haas Electronic Materials LLC

New methods are provided for synthesis of photoacid generator compounds (“PAGs”), new photoacid generator compounds and photoresist compositions that comprise such PAG compounds. In a particular aspect, sulfonium-containing (S+) photoacid generators and methods of synthesis of sulfonium photoacid generators are provided.

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Номер записи: 74
04-05-2017 дата публикации

LIPOCATIONIC DENDRIMERS AND USES THEREOF

Номер: US20170121279A1
Автор: SIEGWART Daniel J., ZHOU Kejin
Принадлежит:

Modular dendrimers with cationic groups and lipophilic groups are provided herein. In some aspects, the dendrimers provided herein may be formulated in compositions which contain a nucleic acid and one or more helper excipients. In some aspects, these compositions may also be used to treat diseases or disorders with a therapeutic nucleic acid. 2. (canceled)5. (canceled)818.-. (canceled)2025.-. (canceled)26. The dendrimer of claim 19 , wherein Ris amino claim 19 , alkylamino claim 19 , substituted alkylamino claim 19 , dialkylamino claim 19 , or substituted dialkylamino.2731.-. (canceled)3545-. (canceled)4759.-. (canceled)60. A composition comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(A) a dendrimer of ; and'}(B) a nucleic acid.61. The composition of claim 60 , wherein the nucleic acid is siRNA claim 60 , a miRNA claim 60 , a pri-miRNA claim 60 , a messenger RNA (mRNA) claim 60 , a cluster regularly interspaced short palindromic repeats (CRISPR) related nucleic acid claim 60 , a single guide RNA (sgRNA) claim 60 , a CRISPR-RNA (crRNA) claim 60 , a trans-activating crRNA (tracrRNA) claim 60 , a plasmid DNA (pDNA) claim 60 , a transfer RNA (tRNA) claim 60 , an antisense oligonucleotide (ASO) claim 60 , a guide RNA claim 60 , a double stranded DNA (dsDNA) claim 60 , a single stranded DNA (ssDNA) claim 60 , a single stranded RNA (ssRNA) claim 60 , and a double stranded RNA (dsRNA).62. The composition of claim 61 , wherein the nucleic acid is a siRNA claim 61 , a tRNA claim 61 , or a nucleic acid which may be used in a CRISPR process.63. The composition of claim 60 , wherein the dendrimer and the nucleic acid are present in a weight ratio from about 100:1 to about 1:5.64. The composition of claim 60 , wherein the composition further comprises one or more helper lipids.65. The composition of claim 64 , wherein the helper lipid is selected from a steroid claim 64 , a steroid derivative claim 64 , a PEG lipid claim 64 , or a phospholipid.6677.-. (canceled)78 ...

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Номер записи: 75
25-08-2022 дата публикации

ORGANIC COMPOUND AND ORGANIC LIGHT-EMITTING ELEMENT

Номер: US20220267256A1
Автор: Ito Yuto, Kamatani Jun, Kawata Isao, Miyashita Hirokazu, Shiobara Satoru, Yamada Naoki
Принадлежит:

The present disclosure provides an organic compound that has a mother skeleton with a fused-ring structure, an electron-withdrawing group bonded to the mother skeleton, and an electron-donating group bonded to the mother skeleton, wherein the electron-withdrawing group is bonded at a position satisfying the following relationship in the mother skeleton. 1. An organic compound comprising: a mother skeleton with a fused-ring structure; an electron-withdrawing group bonded to the mother skeleton; and an electron-donating group bonded to the mother skeleton , wherein the electron-withdrawing group is bonded at a position satisfying the following relationship in the mother skeleton.{'br': None, 'i': C', '|>Σ|C, 'sub': H', 'L, 'Σ||\u2003\u2003(1)'}{'sub': 'H', '(C: 2PZ atomic orbital coefficient of a carbon at a substitution site in HOMO of the mother skeleton)'}{'sub': 'L', '(C: 2PZ atomic orbital coefficient of the carbon at the substitution site in LUMO of the mother skeleton)'}2. The organic compound according to claim 1 , wherein the electron-withdrawing group satisfies the following formula (2) claim 1 , the electron-donating group is provided on a first carbon atom in the mother skeleton such that a substituent can be introduced into at least one of second and third carbon atoms on both sides of the first carbon atom claim 1 , and an electric charge value of a natural bond orbital of the first carbon atom having the electron-donating group in the mother skeleton is equal to or lower than an electric charge value of a natural bond orbital of the second carbon atom adjacent to the first carbon atom and equal to or lower than an electric charge value of a natural bond orbital of the third carbon atom adjacent to the first carbon atom.{'br': None, 'i': 'E−Eb', '≤−1.51 (eV)\u2003\u2003(2)'}(E: a LUMO level of a substituent in the mother skeleton, Eb: a LUMO level of a structure in which the electron-withdrawing group is removed from the substituent)3. The organic ...

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Номер записи: 76
25-04-2019 дата публикации

Pharmaceutical compounds

Номер: US20190119309A1
Автор: James MARECEK, Lakmal Boteju, Paul Bingham, Robert Rodriguez, Robert Shorr, Thomas Kwok
Принадлежит: Rafael Pharmaceuticals Inc

Therapeutically-effective amounts of novel analogs or derivatives of alkyl fatty acids, such as but not limited to lipoic acid, and pharmaceutical formulations comprising such analogs or derivatives and pharmaceutically-acceptable carriers therefor, are useful for the treatment, prevention, imaging, and/or diagnosis of medical disorders.

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Номер записи: 77
16-04-2020 дата публикации

Polybrominated diphenyl-based flame retardant compounds

Номер: US20200115308A1
Автор: Brandon M. Kobilka, Jason T. Wertz, Joseph Kuczynski, Scott B. King
Принадлежит: International Business Machines Corp

A process of forming a flame retardant material is disclosed. The process includes forming a functionalized polybrominated diphenyl-based flame retardant compound having the following structural formula: In the structural formula, X corresponds to a functional group. The process also includes forming a flame retardant material by covalently bonding the functionalized polybrominated diphenyl-based flame retardant compound into a material using the functional group.

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Номер записи: 78
24-07-2014 дата публикации

Charge controlling agent and toner using same

Номер: US20140205945A1
Автор: Ikuo Kimura, Masafumi Asakai, Masami Ito, Masaya Tojo
Принадлежит: Hodogaya Chemical Co Ltd

To provide a charge controlling agent for electrophotography, which presents sufficient triboelectric chargeability to a toner, is useful particularly for a color toner and further for a polymerized toner, increases a charge rising rate, has a high electric charge amount, is excellent in charging characteristics, stability over time and environmental stability and yet is safe without posing any problem regarding waste regulations, and a negatively chargeable toner for developing an electrostatic image, which uses such a charge controlling agent and which has a high charging performance. A charge controlling agent comprising, as an effective component, at least one type of cyclic phenol sulfide represented by the following formula (1), and a toner comprising such a charge controlling agent:

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Номер записи: 79
27-05-2021 дата публикации

AROMATIC SUBSTITUTED ALKANE-CORE MONOMERS AND POLYMERS THEREOF FOR VOLUME BRAGG GRATINGS

Номер: US20210155599A1
Автор: Colburn Matthew E., LANE Austin, PURVIS Lafe
Принадлежит:

The disclosure provides recording materials including aromatic substituted alkane-core derivatized monomers and polymers for use in volume Bragg gratings, including, but not limited to, volume Bragg gratings for holography applications. Several structures are disclosed, including Formula I. When used in Bragg gratings applications, the monomers and polymers disclosed lead to materials with higher refractive index, low birefringence, and high transparency. The disclosed derivatized monomers and polymers can be used in any volume Bragg gratings materials, including two-stage polymer materials where a matrix is cured in a first step, and then the volume Bragg grating is written by way of a second curing step of a monomer. 2. The compound of claim 1 , wherein the substituent comprises one or more linking groups selected from —Calkyl- claim 1 , —O—Calkyl- claim 1 , —Calkenyl- claim 1 , —O—Calkenyl- claim 1 , —Ccycloalkenyl- claim 1 , —O—Ccycloalkenyl- claim 1 , —Calkynyl- claim 1 , —O—Calkynyl- claim 1 , —Caryl- claim 1 , —O—C— claim 1 , -aryl- claim 1 , —O— claim 1 , —S— claim 1 , —S(O)— claim 1 , —C(O)— claim 1 , —C(O)O— claim 1 , —OC(O)— claim 1 , —C(O)S— claim 1 , —SC(O)— claim 1 , —OC(O)O— claim 1 , —N(R)— claim 1 , —C(O)N(R)— claim 1 , —N(R)C(O)— claim 1 , —OC(O)N(R)— claim 1 , —N(R)C(O)O— claim 1 , —SC(O)N(R)— claim 1 , —N(R)C(O)S— claim 1 , —N(R)C(O)N(R)— claim 1 , —N(R)C(NR)N(R)— claim 1 , —N(R)S(O)— claim 1 , —S(O)N(R) claim 1 , —S(O)O— claim 1 , —OS(O)— claim 1 , —OS(O)O— claim 1 , —O(O)P(OR)O— claim 1 , (O)P(O—) claim 1 , —O(S)P(OR)O— claim 1 , and (S)P(O—) claim 1 ,{'sup': 'b', 'wherein w is 1 or 2, and Ris independently hydrogen, optionally substituted alkyl, or optionally substituted aryl.'}3. The compound of claim 1 , wherein the substituent comprises one or more linking groups selected from —(CH)— claim 1 , 1 claim 1 ,2 disubstituted phenyl claim 1 , 1 claim 1 ,3 disubstituted phenyl claim 1 , 1 claim 1 ,4 disubstituted phenyl claim 1 , disubstituted ...

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Номер записи: 80
12-05-2016 дата публикации

ANTIOXIDANT HAVING DIFLUOROMETHOXY GROUP, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY DEVICE

Номер: US20160130501A1
Автор: GOTOH YASUYUKI, SATOU Teizi
Принадлежит:

[Subject] One object of the invention is a compound useful as an antioxidant. Other objects include a liquid crystal composition having high stability to ultraviolet light and heat, and a device that hardly undergoes a decrease in voltage holding ratio even after a long-time use. 2. The compound of claim 1 , wherein in formula (1) claim 1 , Ris hydrogen or alkyl having 1 to 20 carbons claim 1 , wherein at least one —CH— in the alkyl is optionally replaced with —O— or —S—; Rand Rare independently methyl claim 1 , ethyl claim 1 , isopropyl claim 1 , or t-butyl; ring A is 1 claim 1 ,4-cyclohexylene claim 1 , 1 claim 1 ,4-cyclohexenylene claim 1 , tetrahydropyran-2 claim 1 ,5-diyl claim 1 , 1 claim 1 ,4-phenylene claim 1 , or 1 claim 1 ,4-phenylene in which at least one hydrogen is replaced with fluorine or chlorine; Z is a single bond claim 1 , —CHCH— claim 1 , —CH═CH— claim 1 , —C≡C— claim 1 , —COO— claim 1 , —OCO— claim 1 , —CHO— claim 1 , —OCH— claim 1 , —CF═CF— claim 1 , —CFCF— claim 1 , —CHCF— claim 1 , —CHCHF— claim 1 , —CHS— claim 1 , or —SCH—; and m is 0 claim 1 , 1 claim 1 , or 2 claim 1 , wherein when m=2 claim 1 , two rings A may be the same or different claim 1 , and two Z's may be the same or different.3. The compound of claim 1 , wherein in formula (1) claim 1 , Ris alkyl having 2 to 20 carbons; Rand Rare independently methyl claim 1 , ethyl claim 1 , isopropyl claim 1 , or t-butyl; ring A is 1 claim 1 ,4-cyclohexylene claim 1 , 1 claim 1 ,4-phenylene claim 1 , or 1 claim 1 ,4-phenylene in which at least one hydrogen is replaced with fluorine; Z is a single bond claim 1 , —CHCH— claim 1 , —CH═CH— claim 1 , —C≡C— claim 1 , —COO— claim 1 , —OCO— claim 1 , —CHO— claim 1 , or —OCH—; and m is 1 or 2 claim 1 , wherein when m=2 claim 1 , two rings A may be the same or different claim 1 , and two Z's may be the same or different.6. The compound of claim 5 , wherein in formulae (1-2-a) to (1-2-e) claim 5 , Ris alkyl having 2 to 15 carbons; Rand Rare independently ...

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Номер записи: 81
12-05-2016 дата публикации

Novel onium salt compound, resist composition, and pattern forming process

Номер: US20160131972A1
Автор: Jun Hatakeyama, Masahiro Fukushima, Masaki Ohashi
Принадлежит: Shin Etsu Chemical Co Ltd

Sulfonium and iodonium salts of a carboxylate having an aromatic ring to which a nitrogen-containing alkyl or cyclic structure is attached are novel. The onium salt functions as an acid diffusion controlling agent in a resist composition, enabling to form a pattern of good profile with high resolution, improved MEF, LWR and DOF.

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Номер записи: 82
31-07-2014 дата публикации

MACROCYCLES

Номер: US20140212381A1
Автор: LI Keqiang, Peel Michael Robert
Принадлежит: SCYNEXIS, INC.

Cyclosporin derivatives, methods of manufacturing the cyclosporin derivatives and methods for treating subjects infected with certain viruses, including hepatitis virus or HIV by administering the cyclosporin derivatives are described. 1. A cyclosporine A derivative in which the 3-Sarcosine position is substituted by a group —S—CHC[CH(CH)]NRR , wherein Ris hydrogen or an alkyl chain having from one to four carbon atoms and , when the alkyl chain has 3 or 4 carbon atoms , the chain is straight or branched; Ris an alkyl chain having from one to four carbon atoms and , when the alkyl chain has 3 or 4 carbon atoms the chain is straight or branched; and n is 1 or 2.3. The compound of claim 2 , where X is hydroxyl.4. The compound of claim 2 , where A is (E) —CH═CHCH claim 2 , B is ethyl claim 2 , and n is 1.5. The compound of claim 2 , where A is (E) —CH═CHCH claim 2 , B is ethyl claim 2 , n is 1 and Rand Rare each methyl.6. The compound of claim 2 , where{'sub': '3', 'A is (E) —CH═CHCH;'}B is ethyl;n is 1 or 2;{'sup': '1', 'Ris hydrogen or benzyl; and'}{'sup': 2', '3, 'sub': 1', '4, 'Rand R, which may be the same or different, each are a C-Calkyl group.'}7. The compound of claim 1 , which is selected from the group consisting of:{'sup': 3', '4, '[(R)-[(1-(N,N-dimethylamino)cyclopropyl)methylthio-Sar][4′hydroxy-N methylleucine]cyclosporine A;'}{'sup': 3', '4, '[(R)-[(1-(N-methyl-N-isopropylamino)cyclopropyl)methylthio-Sar][4′hydroxy-N methylleucine]cyclosporine A;'}{'sup': 3', '4, '[(R)-[(1-(N,N-dimethylamino)cyclobutyl)methylthio-Sar][4′hydroxy-N methylleucine]cyclosporine A;'}{'sup': 3', '4, '[(R)-[(1-(N,N-diethylamino)cyclopropyl)methylthio-Sar][4′hydroxy-N methylleucine]cyclosporine A;'}{'sup': 3', '4, '[(R)-[(1-(N-ethyl-N-methylamino)cyclopropyl)methylthio-Sar][4′hydroxy-N methylleucine]-cyclosporine A; and'}{'sup': 3', '5, '[(R)-[(1-(N,N-dimethylamino)cyclobutyl)methylthio-Sar]-(N-benzyl)-Valcyclosporine A.'}8. A composition comprising a compound of and a ...

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Номер записи: 83
11-05-2017 дата публикации

URETHANE-MODIFIED PREPOLYMERS CONTAINING PENDENT ALKYL GROUPS, COMPOSITIONS AND USES THEREOF

Номер: US20170129986A1
Автор: BOGHOSSIAN RAZMIK, Sharaby Ahmed
Принадлежит:

Adducts and prepolymers comprising pendent alkyl groups are disclosed. Polythiol adducts prepared by reacting a polythiol with a ketone and urethane-extended polythiol adducts. The polythiol adducts can be terminated with isocyanate groups. Compositions comprising the isocyanate-terminated polythiol adducts, isocyanate-terminated sulfur-containing prepolymers, and diisocyanates can be combined with polyamine or polyepoxide curing agents to provide curable compositions. Cured compositions are suitable for aerospace coating and sealant applications. The compositions can also include a low specific gravity filler and, when cured, meet the requirements of aerospace sealant applications. 1. A polythiol adduct comprising the condensation reaction products of reactants comprising:a polythiol; anda ketone.2. The polythiol adduct of claim 1 , wherein claim 1 , {'br': None, 'sup': 3', '3, 'sub': p', 'q', 'r, 'HS—[(-CHR)—X—]-(CHR)—SH\u2003\u2003(1)'}, 'the polythiol comprises a polythiol having the structure of Formula (1) [{'sup': '3', 'each Rcomprises hydrogen or methyl;'}, 'each X is independently selected from O and S;', 'p is an integer from 2 to 6;', 'q is an integer from 1 to 5; and', 'r is an integer from 2 to 10; and., 'wherein,'} [{'br': None, 'sup': 4', '4, 'R—C(═O)—R\u2003\u2003(3)'}, {'sup': '4', 'sub': '1-5', 'wherein each Rindependently comprises Calkyl.'}], 'the ketone comprises a ketone having the structure of Formula (3)3. The polythiol adduct of claim 1 , wherein claim 1 ,the polythiol comprises dimercaptodiethylsulfide, 3,6-dioxa-1,8-octanedithiol, or a combination thereof; andthe ketone comprises methyl ethyl ketone.4. A polythiol adduct having the structure of Formula (6):{'br': None, 'sup': 1', '2', '1, 'sub': 'n', 'HS—(-R—S—R—S—)-R—SH\u2003\u2003(6)'} n is an integer from 1 to 10;', {'sup': '1', 'claim-text': [{'br': None, 'sup': 3', '3, 'sub': p', 'q', 'r, '-[—(CHR)—X—]-(CHR)—\u2003\u2003(1a)'}, [{'sup': '3', 'each Rcomprises hydrogen or methyl;'}, ' ...

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Номер записи: 84
01-09-2022 дата публикации

IMMUNOREGULATORY AGENTS

Номер: US20220274926A1
Автор: Balog James Aaron, BECK Hilary Plake, Guo Weiwei, JAEN Juan Carlos, OSIPOV Maksim, POWERS Jay Patrick, REILLY Maureen Kay, SHUNATONA Hunter Paul, WALKER James Ross, Williams David K., ZIBINSKY Mikhail
Принадлежит:

Compounds that modulate the oxidoreductase enzyme indoleamine 2,3-dioxygenase, and compositions containing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by indoleamine 2,3-dioxygenase is also provided. 238-. (canceled)39. A pharmaceutical composition comprising a compound of and a pharmaceutically acceptable excipient.40. A method of treating cancer claim 1 , said method comprising administering an effective amount of a compound of claim 1 , to a subject in need thereof.41. A method of claim 40 , wherein said compound is administered concurrently with claim 40 , subsequent to claim 40 , or prior to claim 40 , radiation treatment.4245-. (canceled)46. A method of claim 40 , wherein said cancer is a cancer of the prostate claim 40 , colon claim 40 , rectum claim 40 , pancreas claim 40 , cervix claim 40 , stomach claim 40 , endometrium claim 40 , brain claim 40 , liver claim 40 , bladder claim 40 , ovary claim 40 , testis claim 40 , head claim 40 , neck claim 40 , skin (including melanoma and basal carcinoma) claim 40 , mesothelial lining claim 40 , white blood cell (including lymphoma and leukemia) claim 40 , esophagus claim 40 , breast claim 40 , muscle claim 40 , connective tissue claim 40 , lung (including small-cell lung carcinoma and non-small-cell carcinoma) claim 40 , adrenal gland claim 40 , thyroid claim 40 , kidney claim 40 , or bone; or is glioblastoma claim 40 , mesothelioma claim 40 , renal cell carcinoma claim 40 , gastric carcinoma claim 40 , sarcoma (including Kaposi's sarcoma) claim 40 , choriocarcinoma claim 40 , cutaneous basocellular carcinoma claim 40 , or testicular seminoma.47. A method of claim 40 , wherein said cancer is selected from the group consisting of melanoma claim 40 , colon cancer claim 40 , pancreatic cancer claim 40 , breast cancer claim 40 , ...

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Номер записи: 85
19-05-2016 дата публикации

SYNTHESIS OF CYCLOPHANES FROM A SELF-ASSEMBLY REACTION

Номер: US20160137598A1
Автор: Collins Mary, Johnson Darren W.
Принадлежит: University of Oregon

Disclosed herein is a novel method for preparing cyclophanes, comprising forming a disulfide cyclophane by contacting a linker moiety which includes two or more thiol groups, with a metal salt and an oxidant. The disulfide cyclophane is then desulfurized to form a thiacyclophane comprising thioether bridges. This thiacyclophane optionally may be further desulfurized to form an unsaturated hydrocarbon cyclophane, which can then be reduced to form a saturated hydrocarbon cyclophane. The various cyclophanes can be synthesized in a ring form, such as a dimer, trimer or tetramer etc., or they can be synthesized in a tetrahedral or larger structure. Also disclosed are novel cyclophanes formed by the disclosed method. 5. The compound of claim 1 , wherein m is greater than 0.6. The compound of claim 1 , wherein p is greater than 3.7. The compound of claim 1 , wherein each R independently is heteroaliphatic.8. The compound of claim 7 , wherein each R is methoxy.9. The compound of claim 1 , wherein each L independently is aliphatic or aralkyl.10. The compound of claim 9 , wherein at least one L is CH11. The compound of claim 9 , wherein at least one L is benzyl.12. The compound of claim 1 , wherein ring 1 is phenyl claim 1 , napthyl or biphenyl.14. The compound of claim 13 , wherein each Rand Ris hydrogen.15. The compound of claim 13 , wherein each Ris hydrogen or alkoxy. This application claims the benefit of the earlier filing date of U.S. Provisional Application No. 62/081,398, filed on Nov. 18, 2014, the contents of which are incorporated herein by reference in its entirety.Since the first synthesis of metacyclophane by Pellegrin in 1899 and paracyclophane by Cram et al. in 1951, there has been wide interest in these highly strained systems. The restricted positions of the often distorted aromatic rings in these classes of molecules have allowed many studies of the fundamental properties of aromaticity itself. The well-defined topology and high strain of cyclophanes has ...

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Номер записи: 86
17-05-2018 дата публикации

Anthranilic acid ester compound or salt thereof, agricultural and horticultural microbicide comprising the compound, and method for using the microbicide

Номер: US20180132482A1
Автор: Atsushi Okada, Eiji YASUKOUCHI, Hiroto Harayama, Naoto Shimizu, Takashi Furuya, Yutaka Abe, Yutaka Kato
Принадлежит: Nihon Nohyaku Co Ltd

In crop production in the fields of agriculture, horticulture and the like, the damage caused by diseases etc. is still immense, and diseases resistant to existing microbicides have emerged. Under such circumstances, the development of novel agricultural and horticultural microbicides is desired. The present invention provides an anthranilic acid ester compound represented by the general formula (1): (wherein A 1 , A 3 and A 4 each represent a CH group, A 2 represents a C-haloalkyl group, R 1 represents an alkyl group, R 3 represents a hydrogen atom or an acyl group, R 4 , R 5 and R 7 each represent a hydrogen atom, R 6 represents a haloalkyl group, Z represents an alkyl group, and m represents 0, 1 or 2), or a salt thereof, an agricultural and horticultural microbicide comprising the compound or a salt thereof as an active ingredient, and a method for using the microbicide.

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Номер записи: 87
17-05-2018 дата публикации

THIOETHER COMPOUNDS AS NITRIFICATION INHIBITORS

Номер: US20180134633A1
Автор: Cunningham Allan F., Dickhaut Joachim, Nave Barbara, Nesvadba Peter, Pasda Gregor, SISAY Mihiret Tekeste, Wallquist Olof, Wissemeier Alexander, ZERULLA Wolfram
Принадлежит:

Provided herein are a use of thioether compounds of formula I as nitrification inhibitors, and agricultural mixtures and compositions including the thioether compounds. 2. The thioether compound of claim 1 , wherein in the compound of formula I{'sup': 1', '2, 'Rand Rare H; and'}p is 1 or 2.6. A composition for use in reducing nitrification comprising at least one compound of formula I as defined in and at least one carrier.7. An agrochemical mixture comprising (i) at least one fertilizer; and (ii) at least one compound of formula I as defined in .8. (canceled)9. (canceled)10. A method for reducing nitrification claim 1 , the method comprising treating a plant growing on at least one of soil claim 1 , soil substituents claim 1 , and a locus claim 1 , soil claim 1 , and soil substituents where the plant is growing or is intended to grow with at least one compound of formula I as defined in .11. The method of claim 10 , further comprising providing the at least one of the plant and the locus claim 10 , soil claim 10 , and soil substituents where the plant is growing or is intended to grow with a fertilizer.12. The method of claim 11 , wherein the treating with the compound of formula I and the providing of the fertilizer are carried out simultaneously.13. A method for treating at least one of a fertilizer and a fertilizer composition claim 1 , comprising applying a nitrification inhibitor as defined in to the at least one of the fertilizer and the fertilizer composition.14. The agrochemical mixture of claim 7 , wherein the fertilizer is selected from the group consisting of a solid ammonium-containing inorganic fertilizer claim 7 , a liquid ammonium-containing inorganic fertilizer claim 7 , a solid organic fertilizer claim 7 , a liquid organic fertilizer claim 7 , and a urea-containing fertilizer.15. The method of claim 10 , wherein the plant is an agricultural plant claim 10 , a vegetable claim 10 , sorghum; a silvicultural plant; an ornamental plant; and a ...

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Номер записи: 88
07-08-2014 дата публикации

Sulfur derivatives as chemokine receptor modulators

Номер: US20140221481A1
Автор: Haiqing Yuan, John E. Donello, Michael E. Garst, Richard L. Beard, Veena Viswanath, Xiaoxia Liu
Принадлежит: Allergan Inc

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

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Номер записи: 89
30-04-2020 дата публикации

COMPOUND HAVING ENHANCING ACTIVITY FOR GLUCAGON-LIKE PEPTIDE-1 RECEPTOR ACTIONS

Номер: US20200129458A1
Автор: FUJII Tomohiro, KITAHARA Yoshiro, Kitajima Seiji, Ohsumi Koji
Принадлежит: AJINOMOTO CO., INC.

Compounds represented by formula (I): 2. The compound or salt according to claim 1 , wherein{'sub': '6-14', 'A is a Caryl group or a 5- or 6-membered monocyclic aromatic heterocyclic group, each of which is optionally further substituted,'}L is a bond or a methylene group,Q is an oxygen atom,{'sup': 4', '5, 'sub': '1-6', 'Rand Rare the same or different and are each independently a hydrogen atom or an optionally substituted Calkyl group, and'}n is 1 or 2.3. The compound or salt according to claim 1 , wherein{'sub': 1-6', '1-6', '1-6', '1-3', '1-6', '1-6', '1-6', '1-3', '1-6', '1-6', '1-6', '1-3, 'A is a phenyl group optionally further substituted by the same or different 1 to 5 substituents selected from the group consisting of a halogen atom, a hydroxy group, a carboxy group, a sulfanyl group, an optionally substituted Calkyl group, an optionally substituted Calkoxy group, an optionally substituted amino group, a Calkylthio group optionally substituted by a halogen atom, and a Calkylenedioxy group, or a pyridyl group optionally further substituted by the same or different 1 to 4 substituents selected from the group consisting of a halogen atom, a hydroxy group, a carboxy group, a sulfanyl group, an optionally substituted Calkyl group, an optionally substituted Calkoxy group, an optionally substituted amino group, a 4- to 7-membered monocyclic non-aromatic heterocyclic group, a Calkylthio group optionally substituted by a halogen atom, and a Calkylenedioxy group, B is a benzene ring optionally further substituted by the same or different 1 to 4 substituents selected from the group consisting of a halogen atom, a hydroxy group, a sulfanyl group, an optionally substituted Calkyl group, an optionally substituted Calkoxy group, an optionally substituted amino group, a Calkylthio group optionally substituted by a halogen atom, a Calkylenedioxy group, and a 4- to 7-membered monocyclic non-aromatic heterocyclic group,'}L is a bond or a methylene group,{'sup': '1', 'sub': 1 ...

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Номер записи: 90
08-09-2022 дата публикации

ADDITIVE FOR IMPARTING ULTRAVIOLET ABSORBENCY AND/OR HIGH REFRACTIVE INDEX TO MATRIX, AND RESIN MEMBER USING SAME

Номер: US20220281851A1
Автор: KANEKO Kotaro, KANEKO Nobuhiro, KAWAI Koji, OKAMOTO Kuniyoshi, SHISHINO Yuichi
Принадлежит:

Provided is an additive for imparting ultraviolet absorbency, or an additive for imparting a high refractive index, which has satisfactory compatibility with a resin serving as a matrix and can maintain high transparency even if added in high concentrations. Also provided is an additive with which the function of imparting both ultraviolet absorbency and a high refractive index can be realized by means of one kind of additive. This additive is represented by the following Formula (I): 169-. (canceled)71. The resin composition according to claim 70 , wherein the aromatic group is a phenyl group.72. The resin composition according to claim 70 , wherein the thermoplastic resin is selected from the group consisting of an acrylic resin; a polyolefin-based resin; a polyester resin selected from the group consisting of polycarbonate claim 70 , polyethylene terephthalate and polyethylene naphthalate; polyurethane; polythiourethane; polystyrene; polyamide; polyimide; acrylonitrile-styrene copolymer; polyether sulfone; polysulfone; a cellulose-based resin; polyvinyl acetate; ethylene-vinyl acetate copolymer; polyvinylpyrrolidone; polyvinyl chloride; polyvinylidene chloride; polyether ether ketone; polyacetal; and nylon.73. The resin composition according to claim 72 , wherein the thermoplastic resin is selected from the group consisting of an acrylic resin claim 72 , polyurethane claim 72 , polythiourethane claim 72 , polyethylene terephthalate claim 72 , polystyrene and polycarbonate.74. A transparent resin member comprising the resin composition according to .75. The resin composition according to claim 70 , wherein at least Ria represents a hydroxyl group.76. The resin composition according to claim 75 , wherein at least Rand Rrepresent a t-butyl group or a methyl group.77. The resin composition according to claim 76 , wherein Rrepresents a t-butyl group and at least Rrepresents a methyl group. The present invention relates to an additive for enhancing ultraviolet ...

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Номер записи: 91
26-05-2016 дата публикации

SALT, RESIN, RESIST COMPOSITION AND METHOD FOR PRODUCING RESIST PATTERN

Номер: US20160145205A1
Автор: ICHIKAWA Koji, SAKAMOTO Hiromu
Принадлежит: Sumitomo Chemical Company, Limited

A salt represented by formula (1): 2. The salt according to claim 1 , wherein{'sup': '1', 'Lis a group represented by the formula (b1-1).'}4. The salt according to claim 1 , wherein{'sup': '2', 'sub': 1', '6, 'Lis a Cto Calkanediyl group.'}5. The salt according to claim 1 , wherein{'sup': '3', 'Ris a hydrogen atom.'}6. A resin comprising a structural unit derived from the salt according to .7. The resin according to claim 6 , further comprising a structural unit having an acid-labile group.8. A resist composition comprising at least one selected from among the salt according to and the resin according to .9. A method for producing a resist pattern comprising steps (1) to (5);{'claim-ref': {'@idref': 'CLM-00008', 'claim 8'}, '(1) applying the resist composition according to onto a substrate;'}(2) drying the applied composition to form a composition layer;(3) exposing the composition layer;(4) heating the exposed composition layer, and(5) developing the heated composition layer. This application claims priority to Japanese Application No. 2014-238521 filed on Nov. 26, 2014. The entire disclosures of Japanese Application No. 2014-238521 is incorporated hereinto by reference.1. Field of the InventionThe present disclosure relates to a salt, a resin, a resist composition and a method for producing resist pattern.2. Related ArtA resist composition which contains a resin having a structural unit derived from a salt represented by the following formula is described in Patent document of JP 2007-197718A.The present invention provides following inventions of <1> to <9>. <1> A salt represented by formula (I):wherein Qand Qindependently represent a fluorine atom or a Cto Cperfluoroalkyl group,Rand Reach independently represent a hydrogen atom, a fluorine atom or a Cto Cperfluoroalkyl group,z represents an integer of 0 to 6,Rrepresents a hydrogen atom, a fluorine atom, a Cto Calkyl group or a Cto Cfluorinated alkyl group,Rrepresents a Cto Cfluorinated alkyl group,Lrepresents a ...

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Номер записи: 92
28-05-2015 дата публикации

Novel method for preparing polythiol compound and polymeric composition for optical material comprising same

Номер: US20150148512A1
Автор: Dong Gyu Jang, Jong Hyo Kim, Soo Gyun Roh
Принадлежит: KOC SOLUTION CO LTD

The present invention relates to novel methods for preparing a polythiol compound for use in an optical material and polymerizable compositions including a polythiol compound prepared by the methods. According to the methods, a polythiol compound with uniform color, high purity and high quality can be prepared at reduced cost. The polymerizable compositions can be used to manufacture clear, transparent optical lenses with good heat resistance and excellent optical properties.

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Номер записи: 93
10-06-2021 дата публикации

PREPARATION METHOD FOR POLYTHIOL HAVING IMPROVED STORAGE STABILITY

Номер: US20210171491A1
Автор: HONG Seung Mo, KIM Jeongmoo, SEO Hyeon Myeong, SHIN Junghwan
Принадлежит:

According to one embodiment, in producing polythiols in a manner similar to a conventional method, a polythiol having improved storage stability may be produced in a convenient manner by adjusting reaction conditions so as to prevent thiourea from remaining within products. In particular, the equivalent weight of thiourea to be used in a reaction may be adjusted to a predetermined range, thereby reducing the amount of unreacted thiourea, and thiourea may be removed once more in a sub sequent process, thereby effectively removing remaining thiourea while achieving a high yield. The polythiol thus produced does not contain residual thiourea, and thus does not show discoloration or cloudiness caused by precipitates even under prolonged storage or high-temperature conditions. 1. A process for preparing a polythiol , which comprises:reacting 1 equivalent of an organohalide or a polyol containing a sulfur atom with 1.11 to 1.30 equivalents of thiourea;hydrolyzing the reaction product to obtain a crude polythiol; andsubjecting the crude polythiol to acid washing and water washing to remove unreacted thiourea.2. The process for preparing a polythiol of claim 1 , wherein the water washing is repeatedly carried out until the waste liquid has a pH of 6 to 7.3. The process for preparing a polythiol of claim 1 , wherein the polyol is a polyol having a thioether group claim 1 , and the polythiol has a thioether group.8. The process for preparing a polythiol of claim 1 , wherein the acid washing and water washing is repeatedly carried out until no thiourea is detected in the waste liquid.9. The process for preparing a polythiol of claim 1 , wherein the acid washing is carried out using an aqueous acid solution containing 1% by weight to 40% by weight of an inorganic acid selected from the group consisting of hydrochloric acid claim 1 , nitric acid claim 1 , sulfuric acid claim 1 , phosphoric acid claim 1 , boric acid claim 1 , carbonic acid claim 1 , hydrofluoric acid claim 1 , ...

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Номер записи: 94
14-08-2014 дата публикации

Novel organic compound, organic light-emitting device, and display apparatus

Номер: US20140225968A1
Автор: Akihito Saitoh, Jun Kamatani, Naoki Yamada
Принадлежит: Canon Inc

The present invention provides a novel organic compound having a high quantum yield and a high color purity. Provided is an organic compound represented by Formula (1) described in Claim 1 . In Formula (1), R 1 to R 20 are each independently selected from hydrogen atoms, halogen atoms, substituted or unsubstituted alkyl groups, substituted or unsubstituted alkoxy groups, substituted or unsubstituted amino groups, substituted or unsubstituted aryl groups, substituted or unsubstituted heterocyclic groups, substituted or unsubstituted aryloxy groups, substituted or unsubstituted thiol groups, silyl groups, and cyano groups.

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Номер записи: 95
04-06-2015 дата публикации

BENZAMIDE DERIVATIVE

Номер: US20150152047A1
Автор: Hada Kihito, Hara Sousuke, Kawada Hatsuo, Murata Takeshi, Nakanishi Yoshito, Niizuma Satoshi, Shimada Hideaki, Tanaka Hiroshi
Принадлежит:

The present invention relates to benzamide derivatives represented by formula (I) or pharmaceutically acceptable salts thereof. 3. The compound or a pharmaceutically acceptable salt thereof according to or , wherein Q is CH.4. The compound or a pharmaceutically acceptable salt thereof according to any one of to , wherein Rrepresents a hydrogen atom or Calkyl group , wherein the Calkyl group may be substituted with 1 to 5 halogen atoms.5. The compound or a pharmaceutically acceptable salt thereof according to any one of to , wherein Rrepresents a hydrogen atom , chlorine atom , or Calkyl group , wherein the Calkyl group may be substituted with 1 to 5 halogen atoms.6. The compound or a pharmaceutically acceptable salt thereof according to any one of to , wherein Rrepresents a halogen atom , Calkyl group , Calkenyl group , or Calkoxy group , wherein the Calkyl group , Calkenyl group , or Calkoxy group may be substituted with 1 to 5 halogen atoms.7. The compound or a pharmaceutically acceptable salt thereof according to any one of to , wherein{'sup': '6', 'claim-text': {'br': None, '•-X—Y—Z\u2003\u2003(i)'}, 'Rrepresents a hydrogen atom or a group represented by formula (i) below;'}{'sub': '2', 'wherein X represents CH;'}Y represents piperazine, pyrrolidine, piperidine, morpholine, 3,3-dimethylpiperazine, 3,6-diazabicyclo[3.1.1]heptane, azaspiro[2.4]heptane, 2-oxo-1,3-diazinane, 1,2,5-oxadiazepane, 2-oxopiperidine, azetidine, 5-oxa-2,8-diazaspiro[3.5]nonane, 1,8-diazaspiro[5.5]undecane, imidazole, or benzene;{'sub': 2', 'm', '2', '2', 'm', '2', 'm', '2', 'm', '2', 'm, 'Z represents a hydrogen atom, —(CH)NRaRb, —NHCOCHRe, —(CH)NHCORc, —(CH)ORd, —(CH)CORe, —(CH)CONRlRm, piperazine, pyrrolidine, piperidine, or tetrahydropyran; m represents 0, 1, 2, or 3;'}{'sub': 1-6', '3-6', '2', '3', '1-6', '3-6', '1-6', '2', '1-6', '1-6, 'Ra and Rb are identical or different, each representing a hydrogen atom, Calkyl group, Ccycloalkyl group, or —SOCH, wherein the Calkyl group or ...

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Номер записи: 96
25-05-2017 дата публикации

MATERIAL FOR FORMING FILM FOR LITHOGRAPHY, COMPOSITION FOR FORMING FILM FOR LITHOGRAPHY, FILM FOR LITHOGRAPHY, PATTERN FORMING METHOD AND PURIFICATION METHOD

Номер: US20170144954A1
Автор: ECHIGO Masatoshi, MAKINOSHIMA Takashi
Принадлежит:

The material for forming a film for lithography according to the present invention contains a compound represented by the following formula (1): 2. The material for forming the film for lithography according to claim 1 , wherein at least one p is an integer of 1 to 4.3. The material for forming the film for lithography according to claim 1 , wherein at least one Rrepresents the monovalent group having the oxygen atom.7. The resin according to claim 6 , wherein at least one p is an integer of 1 to 4.8. The resin according to claim 6 , wherein at least one Rrepresents the monovalent group having the oxygen atom.9. The resin according to claim 6 , wherein the compound having crosslinking reactivity is an aldehyde claim 6 , a ketone claim 6 , a carboxylic acid claim 6 , a carboxylic acid halide claim 6 , a halogen-containing compound claim 6 , an amino compound claim 6 , an imino compound claim 6 , an isocyanate claim 6 , or an unsaturated hydrocarbon group-containing compound.10. The resin according to claim 6 , which is at least one selected from the group consisting of a novolac-based resin claim 6 , an aralkyl-based resin claim 6 , a hydroxystyrene-based resin claim 6 , a (meth)acrylic acid-based resin and copolymers thereof.13. A material for forming a film for lithography claim 6 , comprising the resin according to .14. A composition for forming a film for lithography claim 6 , comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the material for forming the film for lithography according to , and'}an organic solvent.15. The composition for forming the film for lithography according to claim 14 , further comprising an acid generating agent.16. The composition for forming the film for lithography according to claim 14 , further comprising a crosslinking agent.17. A film for lithography claim 14 , formed using the composition for forming the film for lithography according to .18. A resist pattern forming method claim 14 , comprising{'claim-ref': {'@idref': ' ...

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Номер записи: 97
02-06-2016 дата публикации

PROCESSES FOR THE PREPARATION OF PESTICIDAL COMPOUNDS

Номер: US20160152594A1
Автор: CANTURK Belgin, Clark Thomas, Deamicis Carl, GRAY KAITLYN, KANE Elisabeth J., Lorsbach Beth, MUHUHI Joseck M., Roth Gary, Whiteker Gregory, Yang Qiang, Zhang Yu
Принадлежит:

The present application provides processes for making pesticidal compounds and compounds useful both as pesticides and in the making of pesticidal compounds. 4. (canceled)8. A process according to claim 7 , wherein Ris C-Chaloalkyl.9. A process according to claim 7 , wherein Ris CHCHCF.10. A process according to claim 7 , wherein Ris CH(2 claim 7 ,2-difluorocyclopropyl).12. A process according to claim 11 , wherein Ris CHCHCF.13. A process according to claim 11 , wherein Ris CH(2 claim 11 ,2-difluorocyclopropyl).14. A process to control insects said process comprising applying a molecule according to to a locus to control insects inhabiting said locus.1519.-. (canceled)22. (canceled) This application claims the benefit of the following U.S. Provisional Patent Applications: Ser. No. 62/041,943, filed Aug. 26, 2014; Ser. No. 62/001,923, filed May 22, 2014; and Ser. No. 61/892,113, filed Oct. 17, 2013; the entire disclosures of these applications are hereby expressly incorporated by reference into this Application.This application relates to efficient and economical synthetic chemical processes for the preparation of pesticidal thioether and pesticidal sulfoxides. Further, the present application relates to certain novel compounds necessary for their synthesis. It would be advantageous to produce pesticidal thioether and pesticidal sulfoxides efficiently and in high yield from commercially available starting materials.The following definitions apply to the terms as used throughout this specification, unless otherwise limited in specific instances.As used herein, the term “alkyl” denotes branched or unbranched hydrocarbon chains.Unless otherwise indicated, the term “cycloalkyl” as employed herein alone is a saturated cyclic hydrocarbon group, such as cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl.The term “thio” as used herein as part of another group refers to a sulfur atom serving as a linker between two groups.The term “halogen” or “halo” as used herein alone or as ...

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Номер записи: 98
15-09-2022 дата публикации

Organic electroluminescent element and electronic device using same

Номер: US20220289704A1
Автор: HIROAKI Itoi, Satomi TASAKI, Taro YAMAKI, Yuki Nakano
Принадлежит: Idemitsu Kosan Co Ltd

An organic electroluminescence device comprising: a cathode, an anode, and an organic layer disposed between the cathode and the anode, wherein the organic layer comprises a compound represented by the following formula (1), and a compound A having a Stokes shift of 20 nm or smaller and an emission peak wavelength of 440 nm to 465 nm (at least one of Ar1 and Ar2 is a monovalent group having a structure represented by the following formula (2)).

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Номер записи: 99
16-05-2019 дата публикации

Copper protective agent

Номер: US20190144381A1
Автор: Yue Wu
Принадлежит: Shenzhen China Star Optoelectronics Technology Co Ltd

A copper protective agent is provided. The copper protective agent is represented by a general formula (GI): HS—R (GI); and R is a linear or branched alkyl group having 1 to 20 carbon atoms.

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Номер записи: 100