INHIBITORS OF BETA-SECRETASE

The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates. 2. A compound according to or a pharmaceutically acceptable salt thereof for use as a medicament.3. A pharmaceutical composition comprising at least one compound according to or a pharmaceutically acceptable salt thereof in admixture with a pharmaceutically acceptable adjuvant claim 1 , diluent and/or carrier.4. A compound according to or a pharmaceutically acceptable salt thereof for use in the treatment of a BACE1 mediated disorder or disease.5. A compound or a pharmaceutically acceptable salt thereof for use according to claim 4 , wherein the BACE1 mediated disorder or disease is selected from the group consisting of a neurodegenerative disorder claim 4 , cognitive decline claim 4 , cognitive impairment claim 4 , dementia claim 4 , and disease characterized by the production of β-amyloid deposits or neurofibrillary tangles.6. A compound or a pharmaceutically acceptable salt thereof for use according to claim 5 , wherein the disorder or disease is selected from the group consisting of Alzheimer's disease claim 5 , Trisomy 21 (Down Syndrome) claim 5 , Hereditary Cerebral Hemorrhage with Amyloidosis of the Dutch-type (HCHWA-D) claim 5 , senile dementia claim 5 , cerebral amyloid angiopathy claim 5 , degenerative dementia claim 5 , dementias of mixed vascular and degenerative origin claim 5 , dementia associated with Parkinson's disease claim 5 , dementia associated with progressive supranuclear palsy claim 5 , dementia associated with cortical basal degeneration claim 5 , diffuse Lewy body type of Alzheimer's disease claim 5 , dry age related ...

Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”). 2. A molecule according to claim 1 , wherein Ris selected from the group consisting of H and Cl.3. A molecule according to claim 1 , wherein Ris selected from the group consisting of H claim 1 , Cl claim 1 , Br claim 1 , CH claim 1 , and CF.4. A molecule according to claim 1 , wherein Ris selected from the group consisting of H claim 1 , F claim 1 , Cl claim 1 , CH claim 1 , CF claim 1 , and OCF.5. A molecule according to claim 1 , wherein Ris selected from the group consisting of H claim 1 , F claim 1 , Cl claim 1 , Br claim 1 , CH claim 1 , and CF.6. A molecule according to claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Rare H.7. A molecule according to claim 1 , wherein Ris Cl.8. A molecule according to claim 1 , wherein Ris Cl.9. A molecule according to claim 1 , wherein Ris selected from the group consisting of H claim 1 , Cl claim 1 , and CF.10. A molecule according to claim 1 , wherein Ris selected from the group consisting of H and CH.11. A molecule according to claim 1 , wherein Ris selected from the group consisting of cyclopropyl claim 1 , cyclobutyl claim 1 , cyclopentyl claim 1 , cyclohexyl claim 1 , azetidinyl claim 1 , morpholinyl claim 1 , oxetanyl claim 1 , pyranyl claim 1 , tetrahydrothiophenyl claim 1 , thietanyl claim 1 , thietanyl-oxide claim 1 , and thietanyl-dioxide claim 1 ,{'sub': 3', '3', '3, 'wherein each cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, ...

Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”). 2. A molecule according to claim 1 , wherein Ris selected from the group consisting of H claim 1 , F claim 1 , and Cl.3. A molecule according to claim 1 , wherein Ris selected from the group consisting of H claim 1 , F claim 1 , and Cl.4. A molecule according to claim 1 , wherein Ris F or Cl.5. A molecule according to claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , R claim 1 , and Rare each independently H.6. A molecule according to claim 1 , wherein Ris selected from the group consisting of Cl and Br.7. A molecule according to claim 1 , wherein Ris selected from the group consisting of Cl and Br.8. A molecule according to claim 1 , wherein Ris selected from the group consisting of H claim 1 , Cl claim 1 , and CF.9. A molecule according to claim 1 , wherein Ris selected from the group consisting of H and CH.10. A molecule according to claim 1 , wherein Ris selected from the group consisting of CH claim 1 , CHCH claim 1 , CHCHCH claim 1 , CHCHCHCH claim 1 , CHCHCHOCHCH claim 1 , CH claim 1 , CHCH claim 1 , CHCHCH claim 1 , CHCHCHCH claim 1 , CHCHCHCHCH claim 1 , CHCHCHCHCHCH claim 1 , CHCH(CH) claim 1 , CHcyclopropyl claim 1 , CHCHcyclopropyl claim 1 , CHcyclobutyl claim 1 , CHphenyl claim 1 , CHCHphenyl claim 1 , CHC═CH claim 1 , CHC═CH claim 1 , CHCF claim 1 , CHCHF claim 1 , CHCHCF claim 1 , CHCFCF claim 1 , CHCHCHCF claim 1 , CHCHCFCF claim 1 , CHCFCFCF claim 1 , CHCHCHCHF claim 1 , CHCHSCH ...

Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”). 2. A process to control a pest claim 1 , said process comprising claim 1 , applying to a locus claim 1 , a pesticidally effective amount of a molecule according to . This Application is a continuation of, and claims the benefit of, U.S. nonprovisional application Ser. No. 15/679,415, which was filed Aug. 17, 2017, and which is now allowed; Ser. No. 15/679,415 is a divisional of, and claims the benefit of, U.S. nonprovisional application Ser. No. 15/092,650, which was filed Apr. 7, 2016, and is now U.S. Pat. No. 9,781,935; Ser. No. 15/092,650 claims the benefit of, and priority from, U.S. provisional application Ser. Nos. 62/148,809; 62/148814; 62/148818; 62/148824; 62/148830; and 62/148,837; all of which were filed on Apr. 17, 2015. The entire contents of all of the above-identified applications are hereby incorporated by reference into this Application.This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides.“Many of the most dangerous human diseases are transmitted by insect vectors” (Rivero et al.). “Historically, malaria, dengue, yellow ...

Inhibitors of beta-secretase

The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.

Inhibitors of beta-secretase

The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates.

MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”). 2. A molecule according to wherein the carboxamido claim 1 , and the phenyl claim 1 , which are bonded to the cyclopropane claim 1 , are in the R claim 1 ,R configuration.3. A molecule according to wherein Xis a substituted or unsubstituted heterocyclyl claim 1 , wherein said heterocyclyl is selected from the group consisting of indolyl claim 1 , oxazolyl claim 1 , pyrazinyl claim 1 , pyrazolyl claim 1 , pyridazinyl claim 1 , pyridyl claim 1 , pyrimidinyl claim 1 , tetrazolyl claim 1 , thiadiazolyl claim 1 , thiazolyl claim 1 , thienyl claim 1 , triazinyl claim 1 , [1 claim 1 ,2 claim 1 ,4]triazolo[1 claim 1 ,5-c]pyrimidinyl claim 1 , triazolyl claim 1 , 2 claim 1 ,3-dihydrophthalazine-1 claim 1 ,4-dionyl claim 1 , indolinyl claim 1 , and pyrimidine-2 claim 1 ,4(1H claim 1 ,3H)-dionyl claim 1 ,{'sub': 2', '2', '1', '6', '1', '6', '1', '6', '1', '6', '2', '6', '3', '6', '3', '6, 'wherein substituents are selected from the group consisting of F, Cl, Br, I, H, CN, NH, NO, (C-C)alkoxy, (C-C)alkyl, (C-C)haloalkoxy, (C-C)haloalkyl, (C-C)haloalkenyl, (C-C)halocycloalkenyl, and (C-C)halocycloalkyl.'} This application is a continuation of, and claims the benefit of, U.S. nonprovisional application Ser. No. 16/203,690, which was filed Nov. 29, 2018, now allowed; Ser. No. 16/203,690, is a continuation of nonprovisional application Ser. No. 15/679,415, which was filed Aug. 17, 2017, and is now U.S. Pat. No. 10,219,516; Ser. No. 15/679,415 is a ...

Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto

This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”). 2. A process to control a pest claim 1 , said process comprising claim 1 , applying to a locus claim 1 , a pesticidally effective amount of a molecule according to . This Application is a divisional of, and claims the benefit of, U.S. nonprovisional application Ser. No. 15/092,650, which was filed Apr. 7, 2016, and is now allowed, and which claims the benefit of, and priority from, U.S. provisional applications Ser. Nos. 62/148,830; 62/148,837; 62/148,809; 62/148,814; 62/148,818; and 62/148,824; all of which were filed on Apr. 17, 2015. The entire contents of all of the above-identified applications are hereby incorporated by reference into this Application.This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides.“Many of the most dangerous human diseases are transmitted by insect vectors” (Rivero et al.). “Historically, malaria, dengue, yellow fever, plague, filariasis, louse-borne typhus, trypanomiasis, leishmaniasis, and other vector borne diseases were responsible for more human disease and death in the 17through the early 20centuries ...

INHIBITORS OF BETA-SECRETASE

The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid aggregates. 1. A compound having the following structure:or a pharmaceutically acceptable salt thereof. This application is a continuation of U.S. patent application Ser. No. 15/383,287, filed on Dec. 19, 2016, which is a continuation of U.S. patent application Ser. No. 14/613,550, filed on Feb. 4, 2015, now U.S. Pat. No. 9,526,727, which is a continuation of U.S. patent application Ser. No. 13/784,032, filed Mar. 4, 2013, now U.S. Pat. No. 8,981,112, which, in turn, claims the benefit of U.S. Provisional Application Ser. No. 61/606,786, filed Mar. 5, 2012; the entire contents of each of the aforementioned applications are incorporated herein by reference.The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Mar. 4, 2013, is named 15161953.txt and is 718 bytes in size.The present invention relates to spirocyclic acylguanidines and their use as inhibitors of the β-secretase enzyme (BACE1) activity, pharmaceutical compositions containing the same, and methods of using the same as therapeutic agents in the treatment of neurodegenerative disorders, disorders characterized by cognitive decline, cognitive impairment, dementia and diseases characterized by production of β-amyloid deposits or neurofibrillary tangles.β-Amyloid (also referred to herein as “Abeta” or “Aβ”) deposits and neurofibrillary tangles are two major pathologic characterizations associated with Alzheimer's disease (AD), including the genetically linked early onset ...

Anionic dispersion polymerization process

The invention provides an anionic dispersion polymerization process, wherein the polymerization is improved by an organic isothiocyanate, such as methyl isothiocyanate.

Anionic dispersion polymerization process

A catalyst composition, a process for preparing the catalyst composition and a use of the catalyst composition

Способ анионной дисперсионной полимеризации

1. Способ анионной дисперсионной полимеризации, отличающийся тем, что полимеризацию улучшают с помощью органического изотиоцианата.2. Способ по п.1, отличающийся тем, что органический изотиоцианат включает алкил-, алкенил-, арил- или аралкилизотиоцианат, предпочтительно алкилизотиоцианат, такой как метилизотиоцианат, этилизотиоцианат или пропилизотиоцианат.3. Способ по п.1, отличающийся тем, что количество органического изотиоцианата составляет от 0,1 до 1,0%, предпочтительно от 0,3 до 0,8 мас.% от общей массы мономеров.4. Способ по п.1 для получения анионного дисперсионного полимера, включающий свободно-радикальную полимеризацию смеси, содержащей:i) водорастворимый анионный этилен-ненасыщенный мономер и/или водорастворимый неионный этилен-ненасыщенный мономер,ii) возможно неионный гидрофобный этилен-ненасыщенный мономер,iii) модификатор, включающий органический изотиоцианат,iv) стабилизатор,v) инициатор,vi) водорастворимую соль иvii) воду.5. Способ по п.4, отличающийся тем, что водорастворимый анионный мономер включает акриловую кислоту, метакриловую кислоту, 2-акриламидо-2-метил-1-пропансульфоновую кислоту, акриламидометилмасляную кислоту, малеиновую кислоту, фумаровую кислоту, итаконовую кислоту, винилсульфокислоту, стиролсульфокислоту, винилфосфоновую кислоту, аллилсульфокислоту, аллилфосфоновую кислоту, сульфометилированный акриламид, фосфонометилированный акриламид или водорастворимую соль щелочного металла, щелочноземельного металла или аммониевую соль, а водорастворимый неионный мономер включает акриламид, метакриламид, N-изопропилакриламид, N-трет-бутилакриламид или N-метилолакриламид.6. Способ по п.4, отл РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (51) МПК C08F 2/16 (11) (13) 2013 119 458 A (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2013119458/04, 14.10.2011 (71) Заявитель(и): КЕМИРА ОЙЙ (FI) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): КАРСЕЛЛЬЕР Роза (FI), ЮППО Ари (FI) 15.10.2010 US 61/393, ...

苯乙酸衍生物.制备它们的方法和中间体,以及它们用作杀害虫的组合物和杀真菌剂

本发明提供了式Ⅰ苯乙酸衍生物及其盐,其中各取代基和符号具有下述含义:X代表NOCH 3 ,CHOCH 3 和CHCH 3 ;Y代表NR和O;R,R 1 代表氢和C 1 －C 4 烷基;R 2 代表氢,C 1 －C 6 烷基,C 1 －C 4 卤代烷基和C 3 －C 6 环烷基;R 3 代表C 4 －C 6 环烷基,C 2 －C 6 烷基,取代的C 1 －C 6 烷基,未取代或取代的C 2 －C 6 炔基或未取代或取代的C 2 －C 6 链烯基,R 4 代表氢,未取代或取代的C 1 －C 10 烷基,C 3 －C 6 环烷基,C 2 －C 10 链烯基,C 2 －C 10 炔基,C 1 －C 10 烷基羰基,C 2 －C 10 链烯基羰基,C 3 －C 10 炔基羰基或C 1 －C 10 烷基磺酰基,芳基,芳基羰基,芳基磺酰基,杂芳基,杂芳基羰基或杂芳基磺酰基。本发明还提供了制备这些化合物的方法和中间体,以及它们的应用。

Method of obtaining 3-thiocyanate-4-trifluoromethyl-2,6-dinitroanilines

N-acetonylbenzamides and their use as fungicides

새로운 N-아세토닐 벤즈아미드 화합물 및 이를 함유한 살균조성물이 제공된다. 이들은 특히 식물 병원체균(phtropathogenic fungi)를 방제하는데 유익하다. 본 발명의 화합물은 하기 식을 갖는 화합물 및 농경학적으로 수용가능한 그 염이다. R 1 과 R 3 는 각각 독립적으로 할로 또는 (C 1 -C 4 )알킬이며 ; R 2 는 할로, (C 1 -C 4 )알킬, (C 1 -C 4 )알케닐, (C 2 -C 6 )알카닐, (C 1 -C 4 )알콕시, 혹은 시아노이며 ; R 4 와 R 5 는 각각 독립적으로 (C 1 -C 4 )알킬이나 R 4 , R 5 중 최소하나는 (C 2 -C 4 )알킬이며 ; X는 할로, 티오시아노 혹은 이소티오시아노이다. 본 발명에 의하면 상기 화합물을 이용하여 식물 병원체 균을 방제하는 방법 역시 제공된다.

5-lipoxygenase inhibitive medicinal composition

Nitrate esters and their use for nervous system disorders

신경보호제로서의 효능을 갖는 니트레이트기의 β 또는 γ 위치에 황 또는 인을 포함하는 지방족 니트레이트 에스테르를 제공한다. 바람직한 니트레이트 에스테르를 3-브로모-1,2-프로판디올을 니트로화 반응 및 후속 반응에 의해 목적하는 모노-, 디- 또는 테트라-니트레이트 에스테르를 생성시킬 수도 있다. An aliphatic nitrate ester comprising sulfur or phosphorus at the β or γ position of a nitrate group having efficacy as a neuroprotective agent is provided. Preferred nitrate esters can be produced by nitration of 3-bromo-1,2-propanediol and subsequent reactions to give the desired mono-, di- or tetra-nitrate esters.

PHENYLETHER DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF

Method for anionic dispersion polymerisation

FIELD: chemistry. SUBSTANCE: claimed invention relates to method for anionic dispersion polymerisation, in particular, to method of obtaining anionic highly molecular water-soluble dispersion polymer. Described is method for anionic dispersion polymerisation, in which polymerisation is improved by means of organic isothiocyanate, which includes alkylisothiocyanate, with said method including free-radical polymerisation of mixture, containing: i) water-soluble anionic ethylene-unsaturated monomer and/or water-soluble non-ionic ethylene-unsaturated monomer, ii) possibly non-ionic hydrophobic ethylene-unsaturated monomer, iii) modifier, including organic isothiocyanate, iv) stabiliser, v) initiator, vi) water-soluble salt and vii) water. EFFECT: control of polymerisation reaction rate and obtaining anionic highly molecular water-soluble polymers, useful as flocculants and, in particular, as retaining and draining additives in paper production. 9 cl, 2 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 573 638 C2 (51) МПК C08F 2/16 (2006.01) C08G 18/70 (2006.01) C08F 220/56 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2013119458/04, 14.10.2011 (24) Дата начала отсчета срока действия патента: 14.10.2011 (72) Автор(ы): КАРСЕЛЛЬЕР Роза (FI), ЮППО Ари (FI) (73) Патентообладатель(и): КЕМИРА ОЙЙ (FI) Приоритет(ы): (30) Конвенционный приоритет: R U 15.10.2010 US 61/393,420; 15.10.2010 FI 20106068 (43) Дата публикации заявки: 20.11.2014 Бюл. № 32 (56) Список документов, цитированных в отчете о поиске: CN 101402853 A, 08.04.2009. CN 101402853 A, 08.04.2009. EP 0546514 A1, 16.06.1993. EP 0546514 A1, 16.06.1993. GB 955197 A, 15.04.1964. GB 955197 A, 15.04.1964. EA 11824 B1, 30.06.2009. RU 2008144620 A, 20.05.2010. (86) Заявка PCT: C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 15.05.2013 FI 2011/050890 (14.10.2011) (87) Публикация заявки PCT: 2 5 7 3 6 3 8 WO 2012/049371 (19.04.2012) R U 2 5 7 ...

N-acetonyl benzamide and fungicidal action thereof

本发明涉及下式新型N-丙酮基苯甲酰胺化合 物或其农(艺)学上可受盐及其在控制植物真菌中的 应用，式中R 1 ，R 3 ，R 2 ，R 4 ，R 5 ，X定义见说明书。 此化合物在控制致植物病真菌，尤其是控制卵菌 纲类真菌有效，并且表现出强的杀真菌活性和相对低 的植物毒性。重要的卵菌纲类真菌包括疫霉属，单轴 霉属，霜霉属和假霜霉属，它们能引起诸如土豆和西 红柿的后期枯萎病及葡萄和其它作物的丘陵起伏的 霉病之类的病害。

Soot

ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (11) 2004 124 019 (13) A (51) ÌÏÊ C09C 1/00 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÇÀßÂÊÀ ÍÀ ÈÇÎÁÐÅÒÅÍÈÅ (21), (22) Çà âêà: 2004124019/15, 09.08.2004 (71) Çà âèòåëü(è): ÄÅÃÓÑÑÀ Àà (DE) (30) Ïðèîðèòåò: 08.08.2003 DE 10336575.3 (43) Äàòà ïóáëèêàöèè çà âêè: 27.01.2006 Áþë. ¹ 03 R U Ôîðìóëà èçîáðåòåíè 1. Ñàæà ñ îðãàíè÷åñêèìè ãðóïïàìè, îòëè÷àþùà ñ òåì, ÷òî îðãàíè÷åñêà ãðóïïà ñîäåðæèò òèîöèàíàòíóþ ãðóïïó. 2. Ñàæà ñ îðãàíè÷åñêèìè ãðóïïàìè ïî ï.1, îòëè÷àþùà ñ òåì, ÷òî îðãàíè÷åñêà ãðóïïà ïðåäñòàâë åò ñîáîé N-(4-òèîöèàíàòàëêèë)ñóêöèíèìèäíóþ, N-(4òèîöèàíàòàðèë)ñóêöèíèìèäíóþ, N-(4-òèîöèàíàòàëêèë)àìèäíóþ èëè N-(4òèîöèàíàòàðèë)àìèäíóþ ãðóïïó. 3. Ñàæà ñ îðãàíè÷åñêèìè ãðóïïàìè ïî ï.1, îòëè÷àþùà ñ òåì, ÷òî îðãàíè÷åñêà ãðóïïà ïðåäñòàâë åò ñîáîé N-(4-òèîöèàíàòîôåíèë)ñóêöèíèìèäíóþ èëè N-(4òèîöèàíàòîôåíèë)àìèäíóþ ãðóïïó. 4. Ñïîñîá ïîëó÷åíè ñàæè ïî ï.1, îòëè÷àþùèéñ òåì, ÷òî ñàæó ïîäâåðãàþò âçàèìîäåéñòâèþ ñ ñîäåðæàùèìè äâîéíóþ èëè òðîéíóþ óãëåðîä-óãëåðîäíóþ ñâ çü, êîòîðà íå âë åòñ êîìïîíåíòîì àðîìàòè÷åñêîé ñèñòåìû, îðãàíè÷åñêèìè ñîåäèíåíè ìè, äâîéíà èëè òðîéíà Ñ-Ñ-ñâ çü êîòîðûõ àêòèâèðîâàíà ïî ìåíüøåé ìåðå îäíèì çàìåñòèòåëåì, è îðãàíè÷åñêîå ñîåäèíåíèå ïðè ýòîì ñîäåðæèò ïî ìåíüøåé ìåðå îäíó òèîöèàíàòíóþ ãðóïïó. 5. Ñïîñîá ïîëó÷åíè ñàæè ïî ï.1, îòëè÷àþùèéñ òåì, ÷òî ñàæó ïîäâåðãàþò âçàèìîäåéñòâèþ ñ ñîîòâåòñòâóþùåé ñîëüþ äèàçîíè è ïðè ýòîì ñîëü äèàçîíè ñîäåðæèò òèîöèàíàòíóþ ãðóïïó. 6. Êàó÷óêîâà ñìåñü, îòëè÷àþùà ñ òåì, ÷òî îíà ñîäåðæèò êàó÷óê èëè ñìåñü êàó÷óêîâ è ñàæó ñ îðãàíè÷åñêèìè ãðóïïàìè ïî ï.1. 7. Êàó÷óêîâà ñìåñü ïî ï.6, îòëè÷àþùà ñ òåì, ÷òî ñàæó ñ îðãàíè÷åñêèìè ãðóïïàìè èñïîëüçóþò â êîëè÷åñòâå îò 10 äî 150 ìàñ.÷. â ïåðåñ÷åòå íà 100 ìàñ.÷. êàó÷óêà. 8. Ñïîñîá ïîëó÷åíè êàó÷óêîâîé ñìåñè ïî ï.6, îòëè÷àþùèéñ òåì, ÷òî êàó÷óê èëè ñìåñü êàó÷óêîâ è ñàæó ñ îðãàíè÷åñêèìè ãðóïïàìè ñîâìåñòíî ñìåøèâàþò â ñîîòâåòñòâóþùåì ñìåñèòåëüíîì óñòðîéñòâå. 9. Ïðèìåíåíèå êàó÷óêîâîé ñìåñè ïî ï.6 äë èçãîòîâëåíè ïíåâìàòè÷åñêèõ øèí, ...

N-acetonylbenzamide compounds and their use as bactericides

본 발명은 난균류, 불완전균류, 자낭균류 및 담자균류의 식물병리학적 균들을 포함한 광범위한 균들의 구제에 유용하며 낮은 식물독성을 나타내는 다음 일반식의 N-아세토닐벤즈아미드 화합물들을 제공한다. 상기 식에서, R 1 과 R 2 는 각각 H, (C 1 -C 4 )알킬, (C 2 -C 6 )알켄일 또는 (C 2 -C 6 )알킨일이고 ; R 3 ,R 4 및 R 5 는 각각 H, 할로, (C 1 -C 4 )알킬, (C 2 -C 6 )알켄일, (C 2 -C 6 )알킨일 또는 CR 6 =NOR 7 이되, R 3 , R 4 및 R 5 중 최소한 하나는 CR 6 =NOR 7 이며 ; R 6 는 H, (C 1 -C 4 )알킨, (C 2 -C 6 )알켄일 또는 (C 2 -C 6 )알킨일이고 ; R 7 은 H, (C 1 -C 4 )알킬, (C 3 -C 6 )알켄일, (C 2 -C 6 )알킨일 또는 (C 1 -C 4 )알킬카르보닐옥시 (C 1 -C 4 )알킬이며 ; X와 Y는 각각 H, 할로, 시아노, 티오시아나토, 이소티오시아나토, 또는 (C 1 -C 4 )알킬술포닐옥시이다.

Method of producing methanesulfonamide of 5-(2-chloro-4-trifluoromethylphenoxy) - 2 -nitrobenzoic acid

Process for the preparation of phenoxybenzoic acid derivatives containing a sulphonamide group, by reacting an appropriate phenoxy benzoic acid halide with a sulphonamide in the absence of an acid acceptor and with elimination of hydrohalic acid in the gaseous form.

Sulfonylaminocarboxylic acid sulfur-substituted n-arylamides, method for their preparing (variants), pharmaceutical composition and method for treatment

FIELD: organic chemistry, chemical technology, medicine, pharmacy. SUBSTANCE: invention relates to sulfonylaminocarboxylic acid sulfur-substituted N-arylamides of the formula (I): wherein A 1 means phenylene, thiazolylene and benzothiazolylene being phenylene can be substituted; ring A 2 that comprises carbon atoms and represents benzene ring or aromatic monocyclic 5-6-membered heterocycle comprising one or two ring heteroatoms taken among nitrogen (N), oxygen (O) and sulfur (S) atoms. Compounds are valuable pharmaceutically active compounds used for treatment and prophylaxis of diseases, for example, cardiovascular diseases. Except for, invention relates to methods for preparing compounds of the formula (I), their using for treatment and prophylaxis of above indicated diseases, and for preparing pharmaceutical preparation designated for this purposes and to pharmaceutical preparations comprising compounds of the formula (I). EFFECT: improved preparing method, valuable medicinal and pharmaceutical properties of compounds. 20 cl, 246 ex 6БбУУ$СсС ПЧ сэ (19) 13) ВО” 2 234 497 ^С2 ОМК С 07 С 311/46, 323/41, 323/42 317/40, С 070 295/22, 211/96, 333/34, 277/46, 235/28, 261/16, А 61 К 31/18, 31/38, 31/422 РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 2001103645/04, 25.06.1999 (72) Изобретатель: ШИНДЛЕР Урзула (ОЕ), ШЕНАФИНГЕР Карл (ОЕ), ШТРОБЕЛЬ Хартмут (24) Дата начала действия патента: 25.06.1999 (ОЕ) (30) Приоритет: 08.07.1998 ОЕ 19830430.7 (73) Патентообладатель: АВЕНТИС ФАРМА ДОЙЧЛАНД ГМБХ (0Е) (43) Дата публикации заявки: 10.02.2003 (74) Патентный поверенный: (16) Дата публикации: 20.08.2004 Лебедева Наталья Георгиевна (56) Ссылки: КУ 2059615 СЛ, 10.05.1996. УР 5-39265 А, 19.02.1993. ММО 96/31492 А, 10.10.1996. (85) Дата перевода заявки РСТ на национальную фазу: 08.02.2001 (86) Заявка РСТ: ЕР 99/04426 (25.06.1999) (87) Публикация РСТ: М/О 00/02851 (20.01.2000) (98) Адрес для переписки: ...

Method of producing adamantyl-containing isothiocyanates

FIELD: chemistry. SUBSTANCE: invention relates to chemistry of adamantane derivatives, specifically to a method of producing adamantyl-containing isothiocyanates, which are intermediate products for synthesis of biologically active substances. Proposed method of producing adamantyl-containing isothiocyanates involves reaction of adamantane derivative with an isothiocyanate derivative while boiling in a solvent medium followed by extraction and recrystallisation of reaction product from alcohol. Method is characterised by that adamantane derivative used is adamantyl-containing amine, selected from a series of 1-aminoadamantane, 1-(adamantan-1-yl)-ethane-1-amine or 1-amino-3,5-dimethyladamantane, and isothiocyanate derivative is phenylisothiocyanate. Reaction is carried out in a toluene medium for 3 hours in molar ratio adamantyl-containing amine : phenylisothiocyanate : toluene = 1.2:1:25. Product is separated by distilling solvent. EFFECT: method enables to obtain desired isothiocyanates with high output using a simpler method. 1 cl, 3 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 599 993 C1 (51) МПК C07C 331/18 (2006.01) C07C 331/26 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2015133687/04, 11.08.2015 (24) Дата начала отсчета срока действия патента: 11.08.2015 (45) Опубликовано: 20.10.2016 Бюл. № 29 2 5 9 9 9 9 3 R U (54) СПОСОБ ПОЛУЧЕНИЯ АДАМАНТИЛСОДЕРЖАЩИХ ИЗОТИОЦИАНАТОВ (57) Реферат: Изобретение относится к химии производных производного адамантана используют адамантана, а именно к способу получения адамантилсодержащий амин, выбранный из ряда адамантилсодержащих изотиоцианатов, которые 1-аминоадамантан, 1-(адамантан-1-ил)-этан-1являются полупродуктами для синтеза амин или 1-амино-3,5-диметиладамантан, а в биологически активных веществ. Предлагаемый качестве изотиоцианатного производного способ получения адамантилсодержащих фенилизотиоцианат. Реакцию ведут в среде изотиоцианатов заключается во ...

Molecules with a pesticidal function and intermediate compounds, compositions and methods associated therewith

FIELD: agriculture.SUBSTANCE: invention relates to compounds of the following formula one, as well as to their use in agriculture salts and stereoisomers, which can be used for controlling arthropod pests. In the formula, one R1is H; R2is selected from a group consisting of H, F, Cl, Br and (C1-C4)haloalkyl; R3is selected from a group consisting of H, F, Cl, Br, (C1-C4)alkoxy and (C1-C4)haloalkyl; R4is selected from a group consisting of H, F, Cl, Br and (C1-C4)haloalkyl; R5is H; R6is H; R7is selected from a group consisting of Cl and Br; R8is selected from a group, consisting of Cl and Br; R9is H; R10is H; R11is selected from a group consisting of H and Cl; R12is selected from a group consisting of H and Cl; R13is selected from a group consisting of H, Cl and (C1-C4)haloalkyl; R14is H; R15is selected from a group consisting of (Q), H and (C1-C4)alkyl; R16is selected from a group consisting of: (Q); (C1-C8)alkyl optionally substituted with one or more substitutes selected from a group, consisting of CN, OH, N ((C1-C8)alkyl)2, benzothionyl, pyrazolyl, pyridinyl and thiazolyl; (C1-C8)alkyl-O-(C1-C8)alkyl; (C1-C8)alkyl(C3-C8)cycloalkyl; (C1-C8)alkylphenyl, optionally substituted with one or more substitutes selected from a group consisting of F, (C1-C8)alkyl, (C1-C8)alkoxy, (C1-C8)haloalkyl and thiazolyl; (C2-C8)alkynyl, (C1-C8)haloalkyl, optionally substituted with one or more substituents selected from the group consisting of OH; (C1-C8)alkyl-S-(C1-C8)alkyl optionally substituted with one or more substituents, selected from the group consisting of C(O)O(C1-C8)alkyl, and furanyl; (C1-C8)alkyl-S(O)-(C1-C8)alkyl; (C1-C8)alkyl-S(O)2-(C1-C8)alkyl; O-phenyl; O-(C2-C8)alkenyl; O-(C1-C8)alkyl(C3-C8)cycloalkyl; O-(C1-C8)alkylphenyl; (C1-C8)alkyl-O-(C1-C8)alkyl(C3-C8)cycloalkyl; (C1-C8)alkyl-O-(C1-C8)haloalkyl; (C1-C8)alkyl-C(=O)NH-(C1-C8)haloalkyl; (C1-C8)alkyl-NHC(O)-(C1-C8)alkyl; (C1-C8)alkyl-S-(C1-C8)haloalkyl; (C1-C8)alkyl-S(O)-(C1-C8)haloalkyl; (C1-C8)alkyl-S(O)2-(C1-C8) ...

Isothiocyanate production method

FIELD: food industry. SUBSTANCE: invention refers to food industry. The method proposed envisages injection of solid byproducts of mustard oil production into a reservoir filled with water, agitation to generate a dispersed system that is subsequently heated, maintained at the heating temperature during 15 minutes and additionally treated to provide for generation of vapour phase eventually delivered for condensation and separation. The maximum content of water the solid products are mixed with in the system is 30%; the additional treatment proceeds under pressure-tight conditions. EFFECT: energy efficiency combined with the process acceleration. ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (11) 2 346 980 (13) C1 (51) ÌÏÊ C11B 13/00 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2007138047/13, 12.10.2007 (72) Àâòîð(û): ×å Ñàí Ãóí (RU), Ãðîøåâ Âëàäèìèð Àëåêñååâè÷ (RU), Íèêèòèí Àíäðåé Åâãåíüåâè÷ (RU) (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 12.10.2007 (45) Îïóáëèêîâàíî: 20.02.2009 Áþë. ¹ 5 Àäðåñ äë ïåðåïèñêè: 400007, ã. Âîëãîãðàä, ïð. Ìåòàëëóðãîâ, ä.23, êâ.42, ïàò.ïîâ. È.Ì.Òðåíîæêèíîé, ðåã.¹ 138 äîïîëíèòåëüíîé îáðàáîòêå äë îáðàçîâàíè ïàðîâîé ôàçû ñ ïîäà÷åé ïîñëåäíåé íà êîíäåíñàöèþ è ðàçäåëåíèå. Òâåðäûå ïðîäóêòû ñìåøèâàþò ñ âîäîé, ñîäåðæàíèå êîòîðîé â ñèñòåìå íå ïðåâûøàåò 30%, à äîïîëíèòåëüíóþ îáðàáîòêó ïðîâîä ò ïîä âàêóóìîì. Èçîáðåòåíèå ïîçâîë åò ñíèçèòü ýíåðãîçàòðàòû è ñîêðàòèòü äëèòåëüíîñòü ïðîöåññà. R U 2 3 4 6 9 8 0 (57) Ðåôåðàò: Èçîáðåòåíèå îòíîñèòñ ê ïèùåâîé ïðîìûøëåííîñòè. Ñïîñîá ïðåäóñìàòðèâàåò ââåäåíèå òâåðäûõ ïîáî÷íûõ ïðîäóêòîâ ãîð÷è÷íîìàñëîáîéíîãî ïðîèçâîäñòâà â åìêîñòü ñ âîäîé ñ îáðàçîâàíèåì ïðè ïåðåìåøèâàíèè äèñïåðñíîé ñèñòåìû, êîòîðóþ ïîñëå íàãðåâà è 15-ìèíóòíîé âûäåðæêè ïðè òåìïåðàòóðå íàãðåâà ïîäâåðãàþò Ñòðàíèöà: 1 RU C 1 C 1 (54) ÑÏÎÑÎÁ ÏÎËÓ×ÅÍÈß ÈÇÎÒÈÎÖÈÀÍÀÒΠ2 3 4 6 9 8 0 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: RU 2196813 Ñ2, 20.01.2003. Êðàòêà ...

Patent RU2017138090A3

’ВИ“” 2017138090” АЗ Дата публикации: 11.10.2019 Форма № 18 ИЗПМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение ж 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2017138090/04(066523) 07.04.2016 РСТ/О$2016/026409 07.04.2016 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от [ ] приоритета к ранее поданной заявке № по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 62/148,818 17.04.2015 05 2. 62/148,830 17.04.2015 05 3. 62/148,837 17.04.2015 05 4. 62/148,824 17.04.2015 05 5. 62/148,814 17.04.2015 05 6. 62/148,809 17.04.2015 05 Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) МОЛЕКУЛЫ С ПЕСТИЦИДНОЙ ФУНКЦИЕЙ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, КОМПОЗИЦИИ И СПОСОБЫ, СВЯЗАННЫЕ С НИМИ Заявитель: ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи, 0$ 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. Примечания) [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) С07С 237/42 (2006.01) С07О 295/32 (2006.01) (070 333/36 (2006.01) С07С 255/46 (2006.01) (070 305/08 (2006.01) (070 331/04 (2006.01) (070 205/04 (2006.01) С07р 309/14 (2006.01) АО1М 37/18 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) С07С 237/42, С07С 255/46, С07Ь 205/04, С07Ь 295/32, С07Ь 305/08, С07Р 309/14, С07Б 333/36, С07Р 331/ ...

Compounds useful as pesticides and intermediate compounds, compositions and methods associated therewith

FIELD: agriculture.SUBSTANCE: present invention relates to compounds of general formula one, as well as to agriculturally acceptable acid addition salts, separated stereoisomers and tautomers, having a pesticidal function with respect to pests of arthropods, molluscs and nematodes. Described also is a pesticide composition and a pest control method, wherein said method comprises applying a pesticide-effective amount of a compound of formula one or a composition containing said compounds to the location thereof.EFFECT: said pesticidal compositions can be used, for example, as acaricides, insecticides, miticides, molluscicides and nematocides.9 cl, 10 tbl, 107 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК C07C 237/42 (2006.01) C07C 255/60 (2006.01) C07C 271/28 (2006.01) C07C 271/66 (2006.01) C07C 317/50 (2006.01) C07C 323/42 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА C07C 331/12 (2006.01) ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ C07C 381/10 (2006.01) C07D 207/452 (2006.01) C07D 209/30 (2006.01) (12) (13) 2 727 811 C2 C07D 209/44 (2006.01) C07D 213/75 (2006.01) C07D 213/81 (2006.01) C07D 213/84 (2006.01) C07D 213/89 (2006.01) C07D 215/38 (2006.01) C07D 231/12 (2006.01) C07D 231/56 (2006.01) C07D 235/24 (2006.01) (см. продолжение) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 237/42 (2019.08); A01N 37/18 (2019.08) 2017139079, 07.04.2016 (24) Дата начала отсчета срока действия патента: 07.04.2016 Дата регистрации: Приоритет(ы): (30) Конвенционный приоритет: 62/148,818; 62/148,830; 62/148,837; 62/148,824; 62/148,814; 62/148809 (43) Дата публикации заявки: 17.05.2019 Бюл. № 14 (45) Опубликовано: 24.07.2020 Бюл. № 21 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 17.11.2017 (86) Заявка PCT: US 2016/026417 (07.04.2016) (87) Публикация заявки PCT: (73) Патентообладатель(и): ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи (US) WO 2016/168059 (20.10.2016) Адрес для переписки: 129090, Москва, ул. Б.Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" R U 2 7 2 7 8 1 1 US US US US US US ( ...

Catalyst composition including silver, method for obtaining same, and application of catalyst composition in ethylene epoxidation

FIELD: chemistry. SUBSTANCE: invention describes a catalyst composition including carrier with surface area of at least 500 m 2 /kg, and sediment on the carrier, made of metal silver; metal or nitrate- or nitrite-forming compound, and IA group metal or component containing IA group metal with atomic index of not less than 37 and additionally potassium, with the value of expression (Q K /R)+Q HIA being within the range of 1.5 to 30 mmol/kg, where Q HIA and Q K are quantity of IA group metal with atomic index over 37 and potassium contained in the catalytic composition, respectively, in mmol/kg, ratio of Q HIA to Q K is at least 1:1, value of Q K is at least 0.01 mmol/kg, R is a non-dimensional value within the range of 1.5 to 5, mmol/kg units are given against the mass of catalyst composition. The invention describes a method for obtaining ethylene oxide by ethylene reaction with oxygen in the presence of the afore said catalyst composition, and a method for obtaining 1,2-ethanediol or ether of 1,2-ethanediol, which involves obtaining of ethylene oxide by the above method and its transformation into 1,2-ethanediol or ether of 1,2-ethanediol. EFFECT: improved catalyst selectivity and service properties throughout its life cycle. 23 cl, 2 tbl, 10 ex ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß RU (19) (11) 2 333 034 (13) C2 (51) ÌÏÊ B01J 23/58 (2006.01) B01J 23/68 (2006.01) B01J 21/04 (2006.01) C07D 301/10 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2005133450/04, 30.03.2004 (72) Àâòîð(û): ÕÅÑÑ Ìàðòèí Ëàéñëè (US), ÌÀÒÓØ Ìàðåê (US), ÐÈ×ÀÐÄ Ìàéêë Àëàí (US) (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 30.03.2004 (73) Ïàòåíòîîáëàäàòåëü(è): ØÅËË ÈÍÒÅÐÍÝØÍË ÐÈÑÅÐ× ÌÀÀÒÑÕÀÏÏÈÉ Á.Â. (NL) (43) Äàòà ïóáëèêàöèè çà âêè: 10.03.2006 R U (30) Êîíâåíöèîííûé ïðèîðèòåò: 31.03.2003 US 60/459,136 (45) Îïóáëèêîâàíî: 10.09.2008 Áþë. ¹ 25 2 3 3 3 0 3 4 (56) Ñïèñîê äîêóìåíòîâ, öèòèðîâàííûõ â îò÷åòå î ïîèñêå: US ...

Novel medicinal composition and preparation

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Patent RU2017135874A3

7 ВУ“? 2017135874`” АЗ Дата публикации: 21.11.2019 Форма № 18 ИЗИМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2017135874/04(062604) 07.04.2016 РСТЛО52016/026413 07.04.2016 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 62/148,818 17.04.2015 05 2. 62/148,830 17.04.2015 05 3. 62/148,837 17.04.2015 05 4. 62/148,824 17.04.2015 05 5. 62/148,814 17.04.2015 05 6. 062/148,809 17.04.2015 05 Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) МОЛЕКУЛЫ С ПЕСТИЦИДНОЙ ФУНКЦИЕЙ И ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ, КОМПОЗИЦИИ И СПОСОБЫ, СВЯЗАННЫЕ С НИМИ Заявитель: ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи, 0$ 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. Примечания) [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) АО1М 37/18 (2006.01) С07С 317/28 (2006.01) (070 205/04 (2006.01) С07С 237/42 (2006.01) С07С 317/40 (2006.01) (070 207/10 (2006.01) С07С 255/29 (2006.01) С07С 323/41 (2006.01) (070 207/452 (2006.01) С07С 255/46 (2006.01) С07С 323/42 (2006.01) (070 209/30 (2006.01) С07С 255/57 (2006.01) С07С 323/59 (2006.01) (070 209/34 (2006.01) С07С 255/60 (2006.01) С07С 3312 (2006.01) (070 209/44 ...

N-acetophenone formamide and application as bactericide agent of same

本发明涉及具有高效杀菌活性和低生理毒性的N-乙酰苯甲酰胺、含有该化合物的组合物以及控制致植物病真菌的方法，该化合物具有如上结构式。

Molecules with a pesticidal function and intermediate compounds, compositions and methods associated therewith

FIELD: agriculture. SUBSTANCE: invention relates to molecules having a pesticidal function with respect to pests of arthropods, molluscs and nematodes. Disclosed is a compound of formula (1), where R 1 and R 5 are selected from H, F, Cl, Br and I; R 2 and R 4 are selected from H, F, Cl, Br, I, CN, (C 1 -C 4 )alkyl, (C 1 -C 4 )alkoxy and (C 1 -C 4 )haloalkyl; R 3 is selected from H, F, Cl, Br, I, NO 2 and (C 1 -C 4 )haloalkoxy; R 6 and R 15 are selected from H and (C 1 -C 4 )alkyl; R 7 and R 8 are selected from a group consisting of F, Cl, Br and I; R 9 , R 10 , R 11 , R 12 and R 14 are H; R 13 is selected from H, F, Cl, Br, I and (C 1 -C 4 )haloalkyl; R 16 is selected from a group consisting of (C 3 -C 8 )cycloalkyl, azetidinyl, isoxazolidinone, morpholinyl, oxazolidinone, oxetanyl, tetrahydrofuranyl, tetrahydropyranyl, tetrahydrothiophenyl, tetrahydrothiophenyl-oxide, tetrahydrothiophenyl-dioxide, which can be optionally substituted with one or more substitutes selected from a group consisting of H, F, Cl, Br, I, CN, oxo, (C 1 -C 4 )alkyl, (C 1 -C 4 )haloalkyl, C(=O)O(C 1 -C 4 )alkyl, (C=O)NH(C 1 -C 4 )alkyl, (C=O)NH(C 1 -C 4 )haloalkyl, C(=O)(C 3 -C 6 )cyclopropyl, C(=O)(C 1 -C 4 )haloalkyl and (C 1 -C 4 )alkyl morpholinyl; and each of Q 1 and Q 2 is O or N-oxides. Also disclosed is a pesticide control method of pest using said compound. (1) EFFECT: technical result is wider range of pesticides. 14 cl, 4 tbl РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (51) МПК C07C 237/42 C07C 255/46 C07D 205/04 C07D 295/32 C07D 305/08 C07D 309/14 ФЕДЕРАЛЬНАЯ СЛУЖБА C07D 333/36 ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ C07D 331/04 A01N 37/18 (12) (11) (13) 2 742 119 C2 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A01N 37/18 (2020.08); A01N 37/22 (2020.08); A01N 37/34 (2020.08); A01N 43/40 (2020.08); A01N 53/00 (2020.08); C07C 237/42 (2020.08); C07C 255/46 (2020.08); C07D 205/04 (2020.08); C07D 295/32 (2020.08); C07D 305 ...

Patent RU2017139079A3

7 ВУ“? 2017139079`” АЗ Дата публикации: 27.01.2020 Форма № 18 ИЗ,ПМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2017139079/04(068125) 07.04.2016 РСТД52016/026417 07.04.2016 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 62/148,818 17.04.2015 05 2. 62/148,830 17.04.2015 05 3. 62/148,837 17.04.2015 05 4. 62/148,824 17.04.2015 05 5. 62/148,814 17.04.2015 05 6. 62/148809 17.04.2015 05 Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) Соединения, полезные в качестве пестицидов, и промежуточные соединения, КОМПОЗИЦИИ и способы, связанные с ними Заявитель: ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи, 0$ 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. Примечания) [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) С07С 237/42 (2006.01) С07О 209/30 (2006.01) (070 235/24 (2006.01) С07С 255/60 (2006.01) С07О 209/44 (2006.01) (070 237/20 (2006.01) С07С 271/28 (2006.01) (070 213/75 (2006.01) (070 239/42 (2006.01) С07С 271/66 (2006.01) (070 213/81 (2006.01) (070 249/08 (2006.01) С07С 317/50 (2006.01) (070 213/84 (2006.01) (070 263/28 (2006.01) С07С 323/42 (2006.01) (070 213/89 (2006.01) ...

Compounds useful as pesticides and intermediates, compositions and methods related thereto

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2020 123 398 A (51) МПК C07C 237/42 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2020123398, 07.04.2016 (71) Заявитель(и): ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи (US) Приоритет(ы): (30) Конвенционный приоритет: (54) Соединения, полезные в качестве пестицидов, и промежуточные соединения, композиции и способы, связанные с ними A R U (57) Формула изобретения 1. Соединение, имеющее следующую формулу Стр.: 1 A 2 0 2 0 1 2 3 3 9 8 Адрес для переписки: 129090, Москва, ул. Б.Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" 2 0 2 0 1 2 3 3 9 8 (43) Дата публикации заявки: 18.09.2020 Бюл. № 26 (72) Автор(ы): ХЕМСТРА, Рональд Дж. (US), РОСС, Рональд (US), ДЕКОРВЕР, Кайл А. (US), ГРЕЙ, Кейтлин (US), КНЮППЕЛЬ, Дэниэл И. (US), ВЕДНОР, Питер (US), МАРТИН, Тимоти П. (US), ЭККЕЛЬБАРДЖЕР, Джозеф Д. (US), ДЭУБЛ, Джон Ф. (US), ХАНТЕР, Рики (US), ДЕМЕТЕР, Дэвид А. (US), ТРАЛЛИНГЕР, Тони К. (US), БАУМ, Эрих В. (US), БЕНКО, Золтан Л. (US), ЧОЙ, Накиен (US), КРАУЗ, Гари Д. (US), ЛИ, Фанчжэн (US), НИССЕН, Джеффри (US), ОЛСОН, Моника Б. (US), РЕЙНЕР, Мишелль (US), СПАРКС, Томас К. (US), УЭССЕЛЗ, Фрэнк Дж. (US), АЙЭП, Морис К. (US) R U 17.04.2015 US 62/148,818; 17.07.2015 US 62/148,830; 17.04.2015 US 62/148,837; 17.04.2015 US 62/148,824; 17.04.2015 US 62/148,814; 17.04.2015 US 62/148,809 (62) Номер и дата подачи первоначальной заявки, из которой данная заявка выделена: 2017139079 10.11.2017 формула один, где (A) R1 представляет собойH; (C) R3 выбирают из группы, состоящей из H, F, Cl, Br, I, (C1-C6)алкила и (C1-C6)галогеналкила; (E) R5 представляет собой H; (F) R6 представляет собой H; A (G) R7 выбирают из группы, состоящей из F и Cl; (H) R8 выбирают из группы, состоящей из F и Cl; (J) Q1 выбирают из группы, состоящей из O и S; (K) Q2 выбирают из группы, состоящей из O и S; (L) R10 выбирают из группы, состоящей из H и (C1-C6)алкила; (M) R11 выбирают из группы, состоящей из H, F, Cl, ...

Acrylic ester and bactericide containing the compound

Patent FR2510105B1

NOVEL (METH) ACRYLIC COMPOUNDS CARRIING THIOCYANATE, THEIR PREPARATION PROCESS AND THEIR APPLICATION FOR OBTAINING NEW POLYMERS.

Ces composés sont choisis parmi ceux de formule: (CF DESSIN DANS BOPI) et ceux de formule (CF DESSIN DANS BOPI) (n = 2-20; R = H, CH3 ou CHOHR' où R' = alkyle linéaire ou ramifié le cas échéant porteurs de substituants hydroxyles, alcoxy ou esters, alcényles linéaires, ramifiés ou cycliques, aryles le cas échéant porteurs de substituants halogénés, nitrés ou alcoxy, hétérocycles insaturés, alkylaryles et arylalkyles.

NOVEL TRICYCLIC COMPOUNDS, THEIR PREPARATION PROCESS, AND INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Method of producing derivatives of tetrazole

Compounds of formula wherein R,, R 2 and R 3 are each independently selected from H, OH, C 1 -C 4 alkyl, R 4 -CO and halogen, where R. is C 1 -C 4 alkyl; R 5 and R. are each independently selected from H, C 1 -C 4 alkyl and optionally-substituted phenyl; R 7 is an alkylene group having from 1 to 4 carbon atoms, optionally containing a substituted or unsubstituted phenyl group; p or 0 or 1; and Z is a 1H-tetrazol-5-yl or a -CN group; and salts thereof, may be prepared by reacting a compound of formula. with a compound of formula wherein R 1 -R 7 are as defined in claim 1, in an organic solvent at a temperature in the range of 40-120°C in the presence of a base, and reacting the resulting compound with an alkali metal cyanide orthiocyanate, and optionally reacting the resulting compound with a source of azide ions to produce pharmacologically active compounds of formula I wherein Z is 1H-tetrazol-5-yl.

NOVEL TRICYCLIC COMPOUNDS, THEIR PREPARATION PROCESS, AND INTERMEDIATES THEREOF, THEIR APPLICATION AS MEDICAMENTS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Compounds of formula (I), wherein R1, R2, R3, R4, R5 and G are as defined in the description and the dotted lines indicate an optional second bond, as well as the acid, base and ester addition salts thereof, a method for preparing said compounds, intermediates therefor, the use of said compounds as drugs, and pharmaceutical compositions containing same, are disclosed.

NOVEL (METH) ACRYLIC COMPOUNDS WITH THIOCYANATE FUNCTION, PROCESS FOR THE PREPARATION THEREOF AND THEIR USE FOR THE PRODUCTION OF NOVEL POLYMERS.

Ces composés sont choisis parmi ceux de formule: (CF DESSIN DANS BOPI) et ceux de formule (CF DESSIN DANS BOPI) (n = 2-20; R = H, CH3 ou CHOHR' où R' = alkyle linéaire ou ramifié le cas échéant porteurs de substituants hydroxyles, alcoxy ou esters, alcényles linéaires, ramifiés ou cycliques, aryles le cas échéant porteurs de substituants halogénés, nitrés ou alcoxy, hétérocycles insaturés, alkylaryles et arylalkyles. These compounds are chosen from those of formula: (CF DRAWING IN BOPI) and those of formula (CF DRAWING IN BOPI) (n = 2-20; R = H, CH3 or CHOHR 'where R' = linear or branched alkyl, in the case of optionally bearing hydroxyl, alkoxy or ester, linear, branched or cyclic alkenyl, aryl, optionally bearing halogenated, nitrated or alkoxy, unsaturated heterocycles, alkylaryl and arylalkyl substituents.

Novel phenolic thioethers and sulphoxides as inhibitors of 5-lipoxygenase

The compounds of the present invention comprise substituted phenolic thioethers represented by the formula: <IMAGE> (I) wherein: R1 and R2 are the same or different and independently represent tert-alkyl or phenyl; A represents methylene or methylene substituted by alkyl, dialkyl or hydroxy, provided that when A includes hydroxymethylene, the hydroxymethylene group is not adjacent to a heteroatom; B represents sulfur, sulfoxide, sulfone, oxygen, -NH- or nitrogen substituted by alkyl, phenyl, benzyl, substituted phenyl or substituted benzyl; C represents methylene or methylene substituted by alkyl; R3 represents CO2H, CO2-alkyl or a tetrazole group; m is 0 or 1, n is 2, 3 or 4 and p is 1, 2 or 3; and the pharmaceutically acceptable salts thereof. The compounds of the present invention are specific inhibitors of 5-lipoxygenase and, therefore, are useful in the treatment of local and systemic inflammation, allergy and hypersensitivity reactions and other disorders in which agents formed in the 5-lipoxygenase metabolic pathway are involved.

Antibacterial agents

The present invention relates to compounds of formula I or a pharmaceutically acceptable salt thereof, wherein X=NH Y=CO, CS, -C(=N-CN) or X and Y together form an alkene, or C3-C5 cycloalkyl; R1 is -COOH; R2 is an electron withdrawing group; R4 is an optionally substituted aryl. The compounds of formula I are antibacterial agents that are useful for sterilization sanitation, antisepsis, and disinfection.

MOLECULES WITH PESTICIDE UTILITY, THEIR INTERMEDIATES, COMPOSITIONS, AND PROCESS TO FIGHT PEST

a presente invenção refere-se ao campo de moléculas que têm utilidade pesticida contra pragas nos filos arthropoda, mollusca e nematoda, processos para produzir essas moléculas, intermediários usados nesses processos, composições pesticidas contendo essas moléculas, e processos de uso dessas composições pesticidas contra tais pragas. essas composições pesticidas podem ser usadas, por exemplo, como acaricidas, inseticidas, miticidas, moluscicidas e nematicidas. este documento divulga moléculas com a seguinte fórmula ("fórmula um"). the present invention relates to the field of molecules that have pesticidal utility against pests in the arthropoda, mollusca and nematoda phyla, processes for producing these molecules, intermediates used in these processes, pesticide compositions containing these molecules, and processes for using such pesticide compositions against such pests. such pesticidal compositions can be used, for example, as acaricides, insecticides, miticides, molluscicides and nematicides. this document discloses molecules with the following formula ("formula one").

Methods of making dihydropyrone HIV protease inhibitors

The present invention relates to methods of making dihydropyrone HIV inhibitors.

Anionic dispersion polymerization process

The present invention relates to an anionic dispersion polymerization process, particularly a process for the preparation of an anionic, high molecular weight water soluble dispersion polymer. High molecular weight water-soluble polymers are useful in the manufacture of paper. They act as flocculants, forming large flocs which deposit on the sheet, and aid in the dewatering of the sheet. According to the present invention it was surprisingly found that by introducing an organic isothiocyanate into an anionic dispersion polymerization process as an improver, it is possible to control the polymerization reaction speed and to obtain anionic, high molecular weight water soluble polymers which are useful as flocculants and especially as retention and drainage aids in the manufacture of paper. It is believed that the organic isothiocyanate makes it possible to control the polymerization reaction speed to get a stabile dispersion and to tailor the various properties of the final polymer.

Phenylacetic acid derivatives, processes and intermediates for their preparation, and compositions comprising them

Phenyl acetic acid derivatives of formula (I) in which: X is NOCH3, CHOCH3 and CHCH3; Y is NMR and O; R, R<1> are hydrogen and C1-4 alkyl; R<2> is hydrogen, C1-C6 alkyl, C1-C4 alkyl halide and C3-C6 cycloalkyl; R<3> is C4-C6 alkyl, substituted C1-C6 alkyl, possibly substituted C2-C6 alkinyl or possibly substituted C2-C6 alkenyl; R<4> is hydrogen, possibly substituted C1-C10 alkenyl, C2-C10 alkinyl, C1-10 alkyl carbonyl, C2-C10 alkenyl carbonyl, C3-C10 alkinyl carbonyl or C1-C10 alkyl sulphonyl, aryl, aryl carbonyl, aryl sulphonyl, hetaryl, hetaryl carbonyl or hetaryl sulphonyl; and their salts, a process and intermediate products for their production and their use.

N-PHENYLBENZAMIDES AND N-PHENYLBENZAMIDOXIMES, METHOD FOR THE PRODUCTION THEREOF, CONTAINERS THEREOF AND THEIR USE AS A PEST CONTROL

N-(2,5-dichloro-4-thiocyanatophenyl)-β-alanine

N-(2,5-Dichloro-4-thiocyanatophenyl)-β-alanine is an effective antifungal agent.

Novel pharmaceutical compounds and their preparation.

Compounds of formula < IMAGE > (I) wherein R1, R2 and R3 are each independently selected from H, OH, C1-C4 alkyl, R4-CO and halogen, where R4 is C1-C4 alkyl R5 and R6 are each independently selected from H, C1-C4 alkyl and optionally-substituted phenyl R7 is an alkylene group having from 1 to 4 carbon atoms, optionally containing a substituted or unsubstituted phenyl group p is 0 or 1 and Z is a 1H-tetrazol-5-yl or a -CN group and salts thereof, may be prepared by reacting a compound of formula. < IMAGE > with a compound of formula < IMAGE > wherein R1-R7 are as defined in claim 1, in an organic solvent at a temperature in the range of 40 DEG -120 DEG C. in the presence of a base, and reacting the resulting compound with an alkali metal cyanide or thiocyanate, and optionally reacting the resulting compound with a source of azide ions to produce pharmacologically active compounds of formula I wherein Z is 1H-tetrazol-5-yl.

SULPHONYLAMINE-CARBOXYLIC ACIDS N-ARILAMIDS REPLACED WITH SULFUR, PROCEDURE FOR THE PREPARATION AND PREPARATION OF PHARMACEUTICAL CONTAINING THEM

N-arilamidas de ácidos sulfonilamino-carboxílicos sustituidas con azufre, de la fórmula (1), en la cual A1 representa un radical bivalente de la serie fenileno, naftileno y heteroarileno, todos los cuales pueden estar sustituidos por uno o más sustituyentes, iguales o diferentes, seleccionados de la serie consistente en: halógeno, alquilo C1-5, fenilo, tolilo, CF3, NO2, OH, -O-C1-5-alquilo, -O-O-C2-4-alquil-O-C1-3-alquilo, C1-2-alquilendioxi, NH2, -NH-C1-3-alquilo, -N(C1-3-alquilo)2, -NH-CHO, -NH-CO-C1-5-alquilo, -CN, -CO-NH2, -CO-C1-3-alquilo, -CO-N(C1-3-alquilo)2, -CO-OH, -CO-O-C1-5-alquilo, heterociclilo, CHO, -CO-(C1-5-alquilo)2, -S(O)n-C1-4-alquilo, -S(O)n-fenilo y -S(O)n-tolilo; el anillo A2, que abarca los átomos de carbono que llevan los grupos C(=X)-NH- y NH-SO2R2, representa un anillo benzol, un anillo naftalina, un carbociclo de 3 a 7 miembros, saturado o parcialmente no saturado, un heterociclo monocíclico de 5 a 7 miembros, saturado, parcialmente no saturado, o aromático, que contiene uno o más heteroátomos de anillo seleccionados de la serie consistente en N, O y S, o un heterociclo bicíclico de 8 a 10 miembros, saturado, parcialmente no saturado, o aromático, que lleva uno o varios heteroátomos de anillo seleccionados de la serie consistente en N, O y S; R1 representa arilo, heterociclilo o C1-18-alquilo, que puede estar sustituido por uno o más radicales R4, iguales o diferentes, o cuando el número n en el grupo R1-S(O)n- vale 2, también representa NR5R6, o cuando el número n en el grupo R1-S(O)n- vale 0, también representa -CN; R2 representa arilo, heterociclilo, NR5R6 o alquilo C1-10 que puede estar sustituido por uno o más radicales R4, iguales o diferentes; R3 representa uno o más radicales, iguales o diferentes, seleccionados de entre la siguiente serie: hidrógeno, halógeno, CF3, OH, -O-C1-7-alquilo, -O-C2-4-alquil-O-C1-7-alquilo, -O-arilo, C1-2-alquilendioxi, NO2, -CN, NR7R8, -CO-NR7R8, -CO-OH, -CO-C1-5-alquilo, heterociclilo, S(O)n-C1-5- ...

N-Acetonylbenzamide and its use of the fungicide

Isothiocyanate derivative and preparation method and application thereof

本发明提供了一种异硫氰酸酯衍生物及其制备方法和应用，该异硫氰酸酯衍生物的分子结构中含有硫代酰胺、硫脲或硫代酰胺酯等亲油基团和羧基亲水基团，其制备方法是使用异硫氰酸酯与醇类、胺类、硫醇或酚类化合物反应得到，该制备方法简单，制备的异硫氰酸酯衍生物作为非钼硫化矿抑制剂应用于硫化钼矿与非钼硫化矿的浮选分离，能有效实现硫化钼矿与硫化铜矿、方铅矿、闪锌矿、黄铁矿、硫化铋矿等分离，提高钼精矿的品位。

Intermediate for preparing tricyclic compound and preparing method thereof

本发明公开了式(I)化合物及其酸和碱加成盐和它们的酯，其中R 1 ，R 2 ，R 3 ，R 4 ，R 5 和G如说明书所定义且虚线表示任选的第二条键，本发明还公开了所述化合物的制备方法，此法的中间体，所述化合物作为药物的应用以及含有它们的药物组合物。

(POLYCHLOROPHENOXY) METHYL THIOCYANATE COMPOUNDS

Microbicidal polychlorophenoxymethylthiocyanates.

Process for the preparation of phenoxybenzoic acid derivatives containing a sulphonamide group

내용 없음.

Dithiocarbamic acid esters

Procedure for the preparation of a cysteine and isotlocyanate cleavable dithiocarbonic acid ester of formula I **(See formula)** in which R stands for an optionally substituted aliphatic or aromatic radical, characterized in that an aqueous solution of cysteine with equimolar dose of an alcoholic solution of isothiocyanate is mixed under certain agitation and under neutral reaction conditions, the mixture is left to stand at room temperature for 2 to 3 days with occasional stirring and then isolates the precipitated dithiocarbamic acid ester. (Machine-translation by Google Translate, not legally binding)

Molecules having pesticidal utility, and intermediates, compositions, and processes, related thereto

of this disclosure This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, pesticidal compositions containing such molecules, 5 and processes of using such pesticidal compositions against such pests. These pesticidal compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula ("Formula One"). R12 R7 R8 R11 R13Ris RQ R6R R4 N N R16 R9 I Rio R14 Q2 R 3 R1 R2 10 Formula One

Tricyclic compounds having activity specific for integrins, particularly alphanubeta3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same

The subject of the invention is the products of formula (I): in which R 1 , R 2 , R 3 , R 4 , R 5 and G are as defined in the description, the dotted lines represent an optional second bond, as well as the addition salts with acids and bases and the esters, their preparation process and the intermediates of this process, their use as medicines and the pharmaceutical compositions containing them.

Novel pharmaceutical compounds and their preparation

Compounds of formula wherein R,, R 2 and R 3 are each independently selected from H, OH, C 1 -C 4 alkyl, R 4 -CO and halogen, where R. is C 1 -C 4 alkyl; R 5 and R. are each independently selected from H, C 1 -C 4 alkyl and optionally-substituted phenyl; R 7 is an alkylene group having from 1 to 4 carbon atoms, optionally containing a substituted or unsubstituted phenyl group; p or 0 or 1; and Z is a 1H-tetrazol-5-yl or a -CN group; and salts thereof, may be prepared by reacting a compound of formula. with a compound of formula wherein R 1 -R 7 are as defined in claim 1, in an organic solvent at a temperature in the range of 40-120°C in the presence of a base, and reacting the resulting compound with an alkali metal cyanide orthiocyanate, and optionally reacting the resulting compound with a source of azide ions to produce pharmacologically active compounds of formula I wherein Z is 1H-tetrazol-5-yl.

Carbamoyloxy derivatives of mutiline and their use as antibacterials

Derivatives of mutiline of formula (1A) and pharmaceutically acceptable salts and derivatives thereof, in which R1 is ethyl or vinyl, Y is a carbamoyloxy group, in which the N-atom is unsubstituted, or mono- or di-substituted, are useful in the treatment of bacterial infections.

Tric clic ompou ds ha ing a tivity specific for integrins particularly avbs intergrins method for preparing same intermediates therefore use of said compounds as drugs and pharmaceutical compositions containing same

Patent PL81800B1

I-Thiocyanato-8-substituted naphthalene derivatives

1-Thiocyanato-8-substituted naphthalene compounds, useful as biocides, especially for protecting aqueous media against infection by microorganisms, have the formula <IMAGE> wherein R is an optionally substituted alkyl, alkoxy, aryl or aryloxy group, a hydroxyl, halo, nitro, cyano, sulphonic acid or primary, secondary or tertiary amino radical or an optionally substituted carbamoyl or sulphamoyl group, and wherein the naphthalene nucleus may contain further substituents and may be fused to a further ring.

Process for the preparation of isothiocyanates

Immune response modulator-active aminophenyl-acetic acid derivatives

Novel phenolic thioethers as inhibitors of 5-lipoxygenase

Process for the preparation of isothiocyanates

There is provided a process for the preparation of isothiocyanates of the formula in which R₁ and R₂ independently of one another are each C₁-C₆-alkyl and R₃, R₄ and R₅ are each hydrogen, halogen, C₁-C₄alkyl, C₁-C₄alkoxy, trifluoromethyl or nitro, represent independently of one another, is described based on the reaction an amine of formula with ammonium or alkali metal thiocyanate in the presence of acid and an inert solvent to thiourea of ​​formula and the thermal decomposition of this thiourea based. The essential feature of the process is that the reaction of the amine of the above formula with ammonium or alkali metal thiocyanate in the presence of 0.5-5 wt.% Of water based on the total weight of the reaction mixture is carried out. The isothiocyanates of the above formula are intermediates for the preparation of pesticidally active compounds.

N-Acetonylbenzamides and their use as fungicides

Process for producing sulfonamide derivatives of phenoxy-benzoic acid

New thio-cyano-phenyl derivatives, preparation and applications

Process for producing rhodanidoisobutyric acid

Chelates for the control of metal-deficiency-phenomena in biological systems

Sulfur-substituted N-arylamides of sulfonylaminocarboxylic acid, process of their preparation, their use and pharmaceutical preparations in which they are comprised

Carbamoyloxy derivatives of methiline and their use as antimicrobial agents

본 발명은 하기 화학식 (1A)의 화합물 또는 약제학적으로 허용되는 염, 및 이들의 유도체의 머틸린의 유도체에 관한 것이며, 이들은 박테리아 감염 치료에 유용하다. (화학식 1A) 상기 식에서, R은 에틸 또는 비닐이며, Y는 N-원자가 비치환되거나, 일치환 또는 이치환된 카르바모일옥시기이다.

Phenolic thioethers and pharmaceutical compositions containing them

4-(pyrrolyl)-salicylic acid derivatives

New salicyclic acid compounds, particularly 4-(heterocyclic)salicylic acid derivatives and process for their preparation are claimed. The new 4-(heterocyclic)salicyclic acid compounds described have anti-inflammatory, anti-pyretic and analgesic activity.

Novel pharmaceutical compounds and their preparation

Preparation of alkylenes monothiocarbonates

Tricyclic compounds having activity specific for integrins, particularly .alpha.v.beta.3 integrins, method for preparing same, intermediates therefor, use of said compounds as drugs, and pharmaceutical compositions containing same

Compounds of formula (I), wherein R¿1?, R¿2?, R¿3?, R¿4?, R¿5? and G are as defined in the description and the dotted lines indicate an optional second bond, as well as the acid, base and ester addition salts thereof, a method for preparing said compounds, intermediates therefor, the use of said compounds as drugs, and pharmaceutical compositions containing same, are disclosed.

Silver catalyst composition, process for preparing catalyst composition and use of catalyst composition for epoxidation of ethylene

Sulfur substituted sulfonylaminocarboxylic acid nm-arylamides, their preparation, their use and pharmaceutical preparations comprising them

4-hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, process for their preparation, their use as pharmaceuticals, and pharmaceutical preparations and precursors

4-Hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, process for their preparation, their use as pharmaceu-ticals, and pharmaceutical preparations and precursors compounds of the formula I and the corresponding open-chain dihydroxycarboxylic acids of the formula II in which X, Y, R1, R2, R3, R4 and R5 have the meanings indicated, and also their pharmacologically tolerable salts with bases and their pharmacologically tolerable esters, processes for the preparation of these compounds, their use as pharmaceuticals and pharmaceutical prepara-tions are described. In addition, compounds of the formula III

Patent FR2147649A5

PROCESS FOR THE MANUFACTURE OF NAFTALENE 1-THIOCIANATE-8-SUBSTITUTED COMPOUNDS AND PROCESS TO PROTECT A MEDIUM THAT IS SUSTAINABLE FROM ATTACK BY MICRO-ORGANISMS AGAINST THIS ATTACK

4-Hydroxytetrahydropyran-2-ones and the corresponding dihydroxycarboxylic acid derivatives, salts and esters, process for their preparation, their use as pharmaceuticals, and pharmaceutical preparations and precursors

Compounds of the formula I …… and the corresponding open-chain dihydroxy carboxylic acids of the formula II …… in which X, Y, R<1>, R<2>, R<3>, R<4>, R<5> have the stated meanings, and their pharmacologically acceptable salts with bases and their pharmacologically acceptable esters, process for the preparation of these compounds, their use as drugs, and pharmaceutical preparations are described. Also described are compounds of the formula III …… in which R<1>, R<2>, R<3>, R<4>, R<5>, X and Y have the stated meanings.

Methods of making dihydropyrone hiv protease inhibitors

The present invention relates to methods of making dihydropyrone HIV protease inhibitors.

Improved reservoir components

The present invention provides linker lipids for use in attaching a membrane including a plurality of ionophores to an electrode and providing a space between the membrane and the electrode. The membrane is either in part or totally made up of the linker lipid. The linker lipid comprises within the same molecule a hydrophobic region capable of spanning at least half the membrane, an attachment group used to attach the molecule to an electrode surface, a hydrophilic region intermediate said hydrophobic region and the attachment group, and a polar head group region attached to the hydrophobic region at a site remote from the hydrophilic region wherein said attachment group has a cross-sectional area that is at least two times the crosssectional area of the hydrophilic region.

Acrylic-acid esters and fungicides containing these compounds

Acrylates of the general formula <IMAGE> wherein R1 and R2 independently of one another are each C1-C8-alkyl, X is hydrogen, C1-C4-alkyl, halogen, C1-C4-alkoxy, haloalkyl, cyano or nitro, W is unsubstituted or alkyl-substituted, saturated or unsaturated C1-C10-alkylene, Y is hydrogen, alkyl, haloalkyl, alkoxyalkyl, cycloalkyl, aralkyl, aryl, aryloxy, halogen, an unsubstituted or substituted C4H4 chain fused to the benzene radical, alkoxy, haloalkoxy, alkylthio, thiocyanato, cyano, NO2, aralkyloxy, <IMAGE> +TR <IMAGE> and R' and R'' independently of one another are each hydrogen, alkyl, alkoxy, alkylthio or cycloalkyl or are each phenyl which is unsubstituted or substituted by alkyl, halogen or alkoxy, and n is from 1 to 4, and fungicides containing them.

New (hydroximino-alkylidene)-imino-oxymethyl-phenyl:acetic acid derivs.

alpha -(Methoximino, methoxymethylene or ethylidene)-2-(oximinoalkylideneaminooxymethyl)-phenylacetic acid derivs. of formula (I) and their salts are new. X = NOMe, CHOMe or CHMe; Y = NR or O; R, R1 = H or 1-4C alkyl; R2 = H, alkyl, 1-4C haloalkyl or cycloalkyl; R3 = (i) 4-6C cycloalkyl; (ii) 2-6C alkyl; or (iii) alkyl, alkynyl or alkenyl, (all partially or completely halogenated and/or substd. by 1-3 of CN, NO2, OH, SH, NH2, COOH, CONH2, CSNH2, halo, mono- or dialkylaminocarbonyl, mono- or dialkylaminothiocarbonyl, alkylsulphonyl, alkylsulphoxyl, alkoxy, haloalkoxy, alkoxycarbonyl, alkylthio, mono- or dialkylamino, alkenyloxy, cycloalkyl, cycloalkoxy, heterocyclyl, heterocyclyloxy, aryl, aryloxy, aryl(1-4C)alkoxy, arylthio, aryl(1-4C)alkylthio, heteroaryl, heteroaryloxy, heteroaryl(1-4C)alkoxy, heteroarylthio and heteroaryl(1-4C)alkylthio (where the cyclic gps. are themselves opt. partially or completely halogenated and/or substd. by 1-3 of CN, NO2, OH, SH, NH2, COOH, CONH2, CSNH2, alkyl, haloalkyl, alkylsulphonyl, alkylsulphoxyl, cycloalkyl, alkoxy, haloalkoxy, alkoxycarbonyl, alkylthio, mono- or dialkylamino, mono- or dialkylaminocarbonyl, mono- or dialkylaminothiocarbonyl, alkenyl, alkenyloxy, benzyl, benzyloxy, aryl, aryloxy, arylthio, heteroaryl, heteroaryloxy, heteroarylthio and C(=NORa)-An-Rb)); R4 = (i) H; (ii) 1-10C alkyl, cycloalkyl, 2-10C alkenyl, 2-10C alkynyl, (1-10C)alkylcarbonyl, (2-10C)alkenylcarbonyl, 3-10C alkynylcarbonyl or 1-10C alkylsulphonyl, all opt. halogenated and/or substd. as for alkyl in R3, or (iii) aryl, arylcarbonyl, arylsulphonyl, heteroaryl, heteroarylcarbonyl or heteroarylsulphonyl (all opt. halogenated and/or substd. as for the cyclic gps. in R3); A = O, S , NH or N(alkyl); n = 0 or 1; Ra, Rb = H or alkyl; alkyl and alkoxy have 1-6C, alkenyl and alkynyl 2-6C and cycloalkyl has 3-6C unless specified otherwise; excluded are cpds. where (a) R1, R2 = Me, R3 = Et, R4 = Me or Et, X = NOMe and Y = NH or O; or (b) R3 = t-Bu.

Process for preparing isothiocyanates

Preparation of phenoxybenzoic acid derivatives containing a sulphonamide group

PROCESS FOR THE PREPARATION OF IRON COMPLEXES OF ETHYLENDIAMINOTETRAACETIC ACID DERIVATIVES

Sulfonylaminocarboxylic acid N-arylamides substituted with sulfur

Bu bulus A1,A2,R1,R2,R3,X ve n'nin istemlerde tanimlandigi gibi oldugu formül (I)'in bilesikleri ile ilgilidir ve bu bilesikler örnegin yüksek tansiyon,angina pectrois, kalp yetmezligi, tromboz ya da aterosklerosis gibi kalp damar hastaliklari gibi hastaliklarin tedavisi ve önlenmesinde kullanilabilen ve farmakolojik olarak etkin degerli bilesiklerdir. Formül formül I'e ait bilesikler bedendeki döngüsel guanosin monofosfat (cGMP) üretimini ayarlayabilme yetisine sahiptir ve genelde dagitilmis bir cGMP dengesi ile iliskili olan hastaliklarin tedavisi ve önlenmesinde kullanilmaya uygundurlar. This invention relates to compounds of formula (I) wherein A1, A2, R1, R2, R3, X, and n are as defined in the claims, and these compounds are cardiovascular, such as high blood pressure, angina pectrois, heart failure, thrombosis, or atherosclerosis. They are pharmacologically effective valuable compounds that can be used in the treatment and prevention of diseases such as diseases. The compounds of formula formula I have the ability to adjust the production of cyclic guanosine monophosphate (cGMP) in the body and are generally suitable for use in the treatment and prevention of diseases associated with a distributed cGMP balance.

Ethylenediaminetetraacetic acid derivatives,their salts and heavy metal chelates,their production and compositions for the control of metal-deficiency phenomena in biological plant systems

Molecules that have pesticide utility, and intermediaries, compositions and processes, related to them

Esta descripción se refiere al campo de moléculas que tienen utilidad plaguicida contra plagas en los filos Arthropoda, Mollusca y Nematoda, procesos para producir tales moléculas, intermediarios usados en tales procesos, composiciones plaguicidas que contienen tales moléculas y procesos para usar tales composiciones plaguicidas contra tales plagas. Estas composiciones plaguicidas pueden usarse, por ejemplo, como acaricidas, insecticidas, aracnicidas, molusquicidas y nematicidas. Este documento describe moléculas que tienen la siguiente fórmula (“Fórmula Uno”). Fórmula Uno This description refers to the field of molecules that have pesticide utility against pests in the Arthropoda, Mollusca and Nematoda edges, processes to produce such molecules, intermediates used in such processes, pesticide compositions containing such molecules and processes to use such pesticidal compositions against such pests These pesticidal compositions can be used, for example, as acaricides, insecticides, arachnicides, molluscicides and nematicides. This document describes molecules that have the following formula ("Formula One"). Formula One