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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 15256. Отображено 100.
05-01-2012 дата публикации

Process for producing alkylated aromatic compounds and process for producing phenols

Номер: US20120004471A1
Автор: Kenji Fujiwara, Masao Imai, Masayasu Ishibashi, Shinobu Aoki, Terunori Fujita, Tsuneyuki Ohkubo
Принадлежит: Mitsui Chemicals Inc

According to a process of the invention, a ketone, an aromatic compound and hydrogen as starting materials are reacted together in a single reaction step to produce an alkylaromatic compound in high yield. A process for producing phenols in the invention includes a step of performing the above alkylation process and does not increase the number of steps compared to the conventional cumene process. The process for producing alkylated aromatic compounds includes reacting an aromatic compound such as benzene, a ketone such as acetone and hydrogen in the presence of a solid acid substance, preferably a zeolite, and a silver-containing catalyst.

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Номер записи: 1
21-06-2012 дата публикации

Cyclic compound, process for production of the cyclic compound, radiation-sensitive composition, and method for formation of resist pattern

Номер: US20120156615A1
Автор: Hiromi Hayashi, Masatoshi Echigo
Принадлежит: Mitsubishi Gas Chemical Co Inc

A cyclic compound represented by formula (1): wherein L, R 1 , R′, and m are as defined in the specification. The cyclic compound of formula (1) is highly soluble to a safety solvent, highly sensitive, and capable of forming resist patterns with good profile. Therefore, the cyclic compound is useful as a component of a radiation-sensitive composition.

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Номер записи: 2
28-06-2012 дата публикации

Cyclic compound, process for preparation thereof, radiation-sensitive composition, and method for formation of resist pattern

Номер: US20120164576A1
Автор: Dai Oguro, Hiromi Hayashi, Masatoshi Echigo
Принадлежит: Mitsubishi Gas Chemical Co Inc

A cyclic compound represented by formula (1): wherein L, R 1 , R′, and m are as defined in the specification. The cyclic compound of formula (1) is highly soluble to a safety solvent, highly sensitive, and capable of forming resist patterns with good profile. Therefore, the cyclic compound is useful as a component of a radiation-sensitive composition.

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Номер записи: 3
12-07-2012 дата публикации

Process For Producing Cyclohexylbenzene

Номер: US20120178969A1
Автор: Jane C. Cheng, Prasenjeet Ghosh, Tan-Jen Chen
Принадлежит: ExxonMobil Chemical Patents Inc

In a process for producing cyclohexylbenzene, benzene and hydrogen are contacted under hydroalkylation conditions with a catalyst system comprising a MCM-22 family molecular sieve and at least one hydrogenation metal. The conditions comprise a temperature of about 140° C. to about 175° C., a pressure of about 135 psig to about 175 psig (931 kPag to 1207 kPag), a hydrogen to benzene molar ratio of about 0.30 to about 0.65 and a weight hourly space velocity of benzene of about 0.26 to about 1.05 hr −1 .

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Номер записи: 4
20-09-2012 дата публикации

Process for preparing alkylated hydroxyaromatics in microreactors

Номер: US20120238783A1
Автор: Hans-Ulrich Moritz, Klaus-Wilhelm Lienert, Oliver Bleifuss, Simon Rost
Принадлежит: Elantas GmbH

A process is proposed for preparing hydroxyaromatics by heterogeneous catalytic reaction of hydroxyaromatics with C 1 -C 4 -alkanols in a microreactor ( 10 ), comprising the steps of: a) introducing the hydroxyaromatic and at least one compound selected from the group consisting of C 1 -C 4 -alkanols as reactants into at least one inlet orifice ( 22 ) of the microreactor ( 10 ) comprising at least one microreactor unit ( 18 ), b) passing the reactants through at least one microreactor unit ( 18 ) of the microreactor ( 10 ), said unit comprising a multitude of microchannels ( 28 ), said microchannels ( 28 ) having a lateral extent of less than 1 mm, and a heterogeneous catalyst being incorporated in the microchannels ( 28 ) for conversion of the reactants, c) passing the hydroxyaromatics prepared out through at least one outlet orifice ( 24 ) of the microreactor ( 10 ).

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Номер записи: 5
04-10-2012 дата публикации

Compounds, compositions, and methods for the treatment of beta-amyloid diseases and synucleinopathies

Номер: US20120252858A1
Автор: Alan D. Snow, F. Michael Hudson, Joel Cummings, Lesley Larsen, Luke A. Esposito, Manfred Weigele, Thomas Lake
Принадлежит: ProteoTech Inc

Dihydroxyaryl compounds and pharmaceutically acceptable esters, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of β-amyloid diseases, such as observed in Alzheimer's disease, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment.

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Номер записи: 6
13-12-2012 дата публикации

METHOD OF RESOLUTION OF (RS)- 1,1'-BI-2-NAPHTHOL FOR OBTAINING ENANTIOMERIC PURE I.E. (S)-(-)-1,1'-BI-2-NAPHTHOL AND/OR (R)-(+)-1,1'-BI-2-NAPHTHOL VIA CO-CRYSTAL FORMATION WITH OPTICALLY ACTIVE DERIVATIVES OF y -AMINO ACIDS

Номер: US20120316361A1
Автор: Bhairab Nath Roy, Girij Pal Singh, Piyushi Suresh Lathi, Rangan Mitra
Принадлежит: Lupin Ltd

Novel method for synthesis of optically pure (S)-(−)-1,1′-bi-2-naphthol and/or (R)-(+)-1,1′-bi-2-naphthol via resolution of racemic (RS)-1,1′-bi-2-naphthol through formation of co-crystal with optically active derivatives of γ-amino acids.

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Номер записи: 7
14-02-2013 дата публикации

Propylene-based polymer, articles, and process for producing same

Номер: US20130041113A1
Автор: Linfeng Chen, William G. Sheard
Принадлежит: Linfeng Chen, William G. Sheard

Disclosed are propylene-based polymer compositions and processes for producing same. Polymerization with an improved catalyst composition provides a propylene-based polymer with improved stiffness.

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Номер записи: 8
07-03-2013 дата публикации

Therapeutic Compounds

Номер: US20130059919A1
Автор: Thomas E. Jenkins
Принадлежит: Individual

A (−)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.

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Номер записи: 9
21-03-2013 дата публикации

PROCESS FOR PREPARING EXTRA PURE 2, 6-DIISOPROPYL PHENOL

Номер: US20130072573A1
Автор: Edaki Dhananjay Uddhavrao, Jain Kirti Prakash, Minhas Gurpreet Singh, Minhas Harpreet Singh
Принадлежит: HARMAN FINOCHEM LIMITED

Disclosed herein is a process for the preparation of highly pure 2,6-diisopropyl phenol (Formula I), which comprises reacting p-hydroxy benzoic acid (Formula II) with an alkylating agent in presence of aq. mineral acid followed by basilication and subsequent washings to yield 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) free of dimer impurity, 4, 4′-oxy-dibenzoic acid of Formula IV, ether impurity 3,5-di(propan-2-yl)-4-(propan-2-yloxy)benzoic acid of Formula V and the monoalkylated impurity 4-hydroxy-3-(propan-2-yl) benzoic acid of Formula VI; and decarboxylating 4-hydroxy-3,5-diisopropylbenzoic acid (Formula III) in presence of high boiling solvent and sodium hydroxide as a catalyst at high temperature to yield 2,6-diisopropyl phenol substantially free of ether impurity 1,3-di(propan-2-yl)-2-(propan-2-yloxy)benzene of Formula VII and monoalkylated phenol impurity 2-(propan-2-yl) phenol of Formula VIII. Propofol prepared by the process of the present invention is suitable for pharmaceutical use. 16-. (canceled)8) The process of claim 7 , wherein step (b) comprises performing at least two steps selected from the group consisting of:i) washing said crude 4-hydroxy-3,5-diisopropylbenzoic acid with toluene at a basic pH to remove 3,5-di(propan-2-yl)-4-(propan-2-yloxy)benzoic acid;ii) washing said crude 4-hydroxy-3,5-diisopropylbenzoic acid with hot water to remove 4,4′-oxydibenzoic acid; andiii) removing 4-hydroxy-3-(propan-2-yl) benzoic acid from said crude 4-hydroxy-3,5-diisopropylbenzoic acid by either:washing said crude 4-hydroxy-3,5-diisopropylbenzoic acid with a mixture of methanol and water, orrecrystallizing said crude 4-hydroxy-3,5-diisopropylbenzoic acid from a mixture of methanol and water.9) The process of claim 7 , wherein step (b) comprises sequentially:i) washing said crude 4-hydroxy-3,5-diisopropylbenzoic acid with toluene at a basic pH to remove 3,5-di(propan-2-yl)-4-(propan-2-yloxy)benzoic acid;ii) washing said crude 4-hydroxy-3,5- ...

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Номер записи: 10
11-04-2013 дата публикации

Cyclohexanone Dehydrogenation Catalyst and Process

Номер: US20130090499A1
Автор: Bakka Jihad M., Chen Tan-Jen, DeCaul Lorenzo C., Helton Terry E., JR. Edward A., Lemon, Miseo Sabato, Xu Teng
Принадлежит:

A catalyst composition comprising: (i) a support; (ii) a first component comprising at least one metal component selected from Group 1 and Group 2 of the Periodic Table of Elements; and (iii) a second component comprising at least one metal component selected from Groups 6 to 10 of the Periodic Table of Elements, wherein the catalyst composition exhibits an oxygen chemisorption of greater than 50%. 2. The process of claim 1 , wherein the inorganic support is at least one material selected from silica claim 1 , a silicate claim 1 , and an aluminosilicate.3. The process of claim 1 , wherein the inorganic support comprises silica.4. The process of claim 1 , wherein the second component comprises at least one metal component selected from platinum and palladium.5. The process of claim 1 , wherein the first component comprises a metal component comprising potassium.6. The process claim 1 , wherein the calcining (b) is conducted in an oxygen-containing atmosphere.7. The process of claim 1 , wherein the calcining (d) is conducted in an oxygen-containing atmosphere.8. The process of claim 1 , wherein the dehydrogenation conditions include a temperature of about 250° C. to about 500° C. claim 1 , a pressure of about 100 to about 3550 kPa claim 1 , a weight hourly space velocity of about 0.2 to 50 hr claim 1 , and a hydrogen to cyclohexanone-containing feed molar ratio of about 2 to about 20 claim 1 ,10. The process of claim 9 , wherein the inorganic support is selected from at least one material selected from silica claim 9 , a silicate claim 9 , and an aluminosilicate.11. The process of claim 9 , wherein the inorganic support comprises silica.12. The process of claim 9 , wherein the second component comprises at least one metal component selected from platinum and palladium.13. The process of claim 9 , wherein the first component comprises a metal component comprising potassium.14. The process of claim 9 , wherein the calcining (b) is conducted in an oxygen-containing ...

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Номер записи: 11
18-04-2013 дата публикации

Process for Preparation of Optically Active Compounds using Transfer Hydrogenation

Номер: US20130096337A1
Автор: Foulkes Michael, Kesselgruber Martin, Mathes Christian
Принадлежит: NOVARTIS AG

A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drug substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmetric catalytic reduction and transfer hydrogenation, thereby providing an improved route to forming drug substances such as rivastigimine and rivastigimine hydrogen tartrate. 139-. (canceled)42. The process of claim 41 , wherein the asymmetric catalytic reduction forms an enantiomeric excess of compound (III) to compound (IV) of from about 96%:4% or higher claim 41 , about 98%:2% or higher claim 41 , or about 99%:1% or higher.43. The process of claim 41 , wherein after a crystallization step the enantiomeric excess of compound (III) to compound (IV) is from about 97%:3% or higher claim 41 , about 98%:2% or higher claim 41 , about 99%:1% or higher claim 41 , or about >99.5%:about <0.5% claim 41 , or about >99.7%:about <0.03.%.44. The process of claim 41 , wherein n=1 in general formulas (I)-(IV).45. The process of claim 41 , wherein n=1 in general formulas (I)-(IV) and a hydroxyl group occurs at position 3 on the aromatic ring.46. The process of claim 40 , wherein Ris a Calkyl claim 40 , Calkenyl claim 40 , Calkynyl claim 40 , or Corganohalide.47. The process of claim 40 , wherein Ris selected from any of methyl claim 40 , ethyl claim 40 , propyl and butyl.49. The process of claim 40 , wherein the transfer hydrogenation is performed using a chiral transition metal based catalyst.50. The process of claim 40 , wherein the transfer hydrogenation is performed using a complexed transition metal based chiral catalyst containing multiple aryl claim 40 , mono- bi- claim 40 , or poly-dentate ligands.51. The process of claim 40 , wherein the transfer hydrogenation is performed using a Ru claim 40 , Rh or Ir based catalyst.52. The process of claim 40 , wherein the transfer hydrogenation is performed using a chiral (diphenylethylenediamine) based ...

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Номер записи: 12
18-04-2013 дата публикации

PROCESS FOR THE SELECTIVE HYDROXYLATION OF BENZENE WITH MOLECULAR OXYGEN

Номер: US20130096351A1
Автор: Bal Rajaram, Ghosh Shilpi, Pendem Chandrashekar, RAWAT Karan Singh, Sarkar Bipul, Shankha Shubhra Acharyya
Принадлежит: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

The present invention provides an improved process for the selective hydroxylation of benzene. The process provides a direct single step selective vapour phase hydroxylation of benzene to phenol using molecular oxygen (air) over Cu—Cr oxide catalysts. The process provides benzene conversion of 10 to 45% and selectivity for phenol up to 100%. 1. An improved process for the selective hydroxylation of benzene with molecular oxygen (air) over solid catalysts which comprises reacting benzene with air in the pressure range of 1-5 MPa , at a temperature of 150-450° C. with a liquid hourly space velocity (LHSV , benzene feed/g catalyst/hour) in the range of 20 to 400 for a period of 1-30 hrs to obtain phenol.2. A process as claimed in claim 1 , wherein solid catalyst is Cu—Cr oxide.3. A process as claimed in claim 1 , wherein the molar ratio of Cu to Cr of the catalyst varied in the range of 0.1 to 0.5.4. A process as claimed in claim 1 , wherein the air pressure is preferably in the range of 2-5 MPa.5. A process according to claim 1 , wherein the reaction temperature is preferably in the range 200-400° C.6. A process as claimed in claim 1 , wherein the liquid hourly space velocity (LHSV) is preferably in the range 30 to 300.7. A process as claimed in claim 1 , wherein the reaction time used is preferably in the range 2-30 h.8. A process as claimed in claim 1 , wherein the conversion of benzene is in the range of 1-42%.9. A process as claimed in claim 1 , wherein the selectivity of the phenol obtained in the range of 50-100%. The present invention relates to an improved process for the selective hydroxylation of benzene with molecular oxygen (air) over solid catalysts. More particularly, the present invention relates to an improved process for the vapour phase selective hydroxylation of benzene to phenol by using molecular oxygen (air) over Cu—Cr oxide.Phenol is a very important chemical for the chemical industry due to its widespread use in the fields of resin, plastics, ...

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Номер записи: 13
02-05-2013 дата публикации

PROCESS FOR PRODUCING BISPHENOL A WITH REDUCED SULFUR CONTENT, POLYCARBONATE MADE FROM THE BISPHENOL A, AND CONTAINERS FORMED FROM THE POLYCARBONATE

Номер: US20130108820A1
Автор: Belfadhel Hatem Abdallah, Brander Eric, de Brouwer Johannes, Vieveen Marcel, Wold Christian
Принадлежит:

In one embodiment, a process for producing a bisphenol A product comprises: reacting phenol with acetone in the presence of a sulfur containing promoter to obtain a reaction mixture comprising bisphenol A, phenol, and the promoter; after reacting the phenol with the acetone, cooling to form a crystal stream comprising crystals of bisphenol A and phenol; separating the crystals from the crystal steam; melting the crystals to form a molten stream of bisphenol A, phenol, and sulfur; contacting the molten stream with a base to reduce a sulfur concentration in the molten stream and form a reduced sulfur stream; and removing phenol from the reduced sulfur stream to form a bisphenol A product. Also disclosed herein is a container comprising: a polycarbonate formed from a bisphenol A having a sulfur concentration of 0.5 to 15 ppm based upon the weight of the bisphenol A. 1. A process for producing a bisphenol A product comprising:reacting phenol with acetone in the presence of a sulfur containing promoter to obtain a reaction mixture comprising bisphenol A, phenol, and the promoter;after reacting the phenol with the acetone, cooling the reaction mixture to form a crystal stream comprising crystals of bisphenol A and phenol;separating the crystals from the crystal steam;melting the crystals to form a molten stream of bisphenol A, phenol, and sulfur;contacting the molten stream with a base to reduce a sulfur concentration in the molten stream and form a reduced sulfur stream; andremoving phenol from the reduced sulfur stream to form a bisphenol A product.2. The process according to claim 1 , wherein the molten stream is contacted with the base at a temperature of 70° C. to 120° C.3. The process according to claim 2 , wherein the temperature is 80° C. to 100° C.4. The process according to claim 1 , wherein the promoter comprises a catalyst selected from 3-mercaptopropionic acid claim 1 , methyl mercaptan claim 1 , ethyl mercaptan claim 1 , 2 claim 1 ,2-bis(methylthio)propane ...

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Номер записи: 14
09-05-2013 дата публикации

METHOD AND SYSTEM FOR PRODUCING GRAPHENE AND GRAPHENOL

Номер: US20130112925A1
Автор: Beall Gary W.
Принадлежит: NATIONAL NANOMATERIALS, INC.

This disclosure includes a process that unexpectedly can produce very inexpensive graphene and a new compound called graphenol in particulate or dispersions in solvents. The process can also produce graphene layers on metallic and nonmetallic substrates. Further, the graphenol and graphene can be utilized to form nanocomposites that yield property improvements exceeding anything reported previously. 1. A process for making graphenol , said process comprising the steps of:providing a carbonaceous material;extracting a humic acid solution from said carbonaceous material via a basic solution, said basic solution having a hydroxide concentration of at least approximately 0.005 moles per liter; and placing said humic acid solution in a pressure reactor;', 'adding a hydrogenation catalyst to said humic acid solution;', 'purging said pressure reactor with an inert gas;', 'charging said pressure reactor with hydrogen gas;', 'heating said humic acid solution; and', 'removing said hydrogenation catalyst from said humic acid solution,, 'chemically reducing at least one of a carbonyl group portion and a carboxylic acid group portion of said humic acid solution, said step of chemically reducing comprising the steps ofthereby producing a solution containing graphenol.2. The process of claim 1 , wherein said carbonaceous material comprises lignite or peat.3. The process of claim 1 , wherein said carbonaceous material comprises leonardite.4. The process of claim 3 , wherein said basic solution is chosen from the group consisting of sodium hydroxide claim 3 , potassium hydroxide claim 3 , and ammonium hydroxide.5. The process of claim 3 , wherein said basic solution comprises ammonium hydroxide claim 3 , and further comprising the step of removing said ammonium hydroxide by heating after said step of chemically reducing said at least one of a carbonyl group portion and a carboxylic acid group portion.6. The process of claim 1 , wherein said step of removing said hydrogenation ...

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Номер записи: 15
09-05-2013 дата публикации

Ordered mesoporous titanosilicate and the process for the preparation thereof

Номер: US20130116453A1
Автор: Anuj Kumar, Srinivas Darbha
Принадлежит: Council of Scientific and Industrial Research CSIR

The invention discloses three-dimensional, ordered, mesoporous titanosilicates wherein the Ti is in a tetrahedral geometry and exclusively substituted for Si in the silica framework. Such titanosilicates find use as catalysts for epoxidation, hydroxylation, C—H bond oxidation, oxidation of sulfides, aminolysis of epoxide and amoximation, with approx. 100% selectivity towards the products.

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Номер записи: 16
16-05-2013 дата публикации

Simultaneous Hydrolysis Refine Method Of Cellulose Biomass

Номер: US20130123547A1
Автор: Chungao Su, Hongping Ye, Meg M. Sun, Zuolin Zhu
Принадлежит: Individual

A method of refining cellulosic biomass, including synchronous hydrolyzation of at least 85 wt % organic polymers, based on the total weight of the cellulosic biomass, in the cellulosic biomass into small molecular organic compounds. The synchronous hydrolyzation is catalytic hydrolyzation for which the catalyst used is a substance represented by L-M-S-H or L-M=S, wherein “M” represents metal, carbon or silicon, “S” represents a heteroatom, “L” represents one or more ligands, and “H” represents hydrogen.

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Номер записи: 17
23-05-2013 дата публикации

Production of renewable aromatic compounds

Номер: US20130130345A1
Автор: David A. Sikkenga, Wendy Thai, Will SCHROEDER
Принадлежит: JNF BIOCHEMICALS LLC

The invention provides a process for producing a variety renewable aromatic compounds such as benzene, toluene, xylenes, and cumene, as well as compounds derived from these including, for example, aniline, benzoic acid, cresol, cyclohexane, cyclohexanone, phenol and bisphenol A, toluene di-isocyanate, isophthalic acid, phthalic anhydride, terephthalic acid and dimethyl terephthalate. The invention also provides for renewable forms of these aromatic compounds.

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Номер записи: 18
06-06-2013 дата публикации

METHOD AND SYSTEM FOR PRODUCING GRAPHENE AND FUNCTIONALIZED GRAPHENE

Номер: US20130140495A1
Автор: Beall Gary W.
Принадлежит: NATIONAL NANOMATERIALS, INC.

This disclosure includes a process that unexpectedly can produce very inexpensive graphene, functionalized graphenes, and a new compound called graphenol in particulate or dispersions in solvents. The process can also produce graphene layers on metallic and nonmetallic substrates. Further, the graphenol, functionalized graphenes, and graphene can be utilized to form nanocomposites that yield property improvements exceeding anything reported previously. 1. A process for making graphenol or functionalized graphenes , said processes comprising the steps of:providing a carbonaceous material;extracting a humic acid solution from said carbonaceous material via a basic solution, said basic solution having a hydroxide concentration of at least approximately 0.005 moles per liter; and placing said humic acid solution in a pressure reactor;', 'adding a hydrogenation catalyst to said humic acid solution;', 'purging said pressure reactor with an inert gas;', 'charging said pressure reactor with hydrogen gas;', 'heating said humic acid solution; and', 'removing said hydrogenation catalyst from said humic acid solution,, 'chemically reducing at least one of a carbonyl group portion and a carboxylic acid group portion of said humic acid solution, said step of chemically reducing comprising the steps ofthereby producing a solution containing graphenol.2. The process of claim 1 , wherein said carbonaceous material comprises lignite or peat.3. The process of claim 1 , wherein said carbonaceous material comprises leonardite.4. The process of claim 3 , wherein said basic solution is chosen from the group consisting of sodium hydroxide claim 3 , potassium hydroxide claim 3 , and ammonium hydroxide.5. The process of claim 3 , wherein said basic solution comprises ammonium hydroxide claim 3 , and further comprising the step of removing said ammonium hydroxide by heating after said step of chemically reducing said at least one of a carbonyl group portion and a carboxylic acid group portion ...

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Номер записи: 19
06-06-2013 дата публикации

METHOD OF PRODUCING IODIZING AGENT, AND METHOD OF PRODUCING AROMATIC IODINE COMPOUND

Номер: US20130144071A1
Автор: Hagiwara Yuji, KATAOKA Kazuhide, MIDORIKAWA Koji, SUGA Seiji, YOSHIDA Junichi
Принадлежит:

A method of the present invention, for producing an iodizing agent, includes the step of electrolyzing iodine molecules in a solution by using an acid as a supporting electrolyte. This realizes (i) a method of producing an iodine cation suitable for use as an iodizing agent that does not require a sophisticated separation operation after iodizing reaction is completed, and (ii) an electrolyte used in the method. Further, a method of the present invention, for producing an aromatic iodine compound, includes the step of causing an iodizing agent, and an aromatic compound whose nucleus has one or more substituent groups and two or more hydrogen atoms, to react with each other under the presence of a certain ether compound. This realizes such a method of producing an aromatic iodine compound that position selectivity in iodizing reaction of an aromatic compound is improved. 17-. (canceled)9. The method of producing an aromatic iodine compound claim 8 , according to claim 8 , wherein:{'sub': '3-12', 'the cyclic ether compound contains a Cring.'}10. The method of producing an aromatic iodine compound claim 8 , according to claim 8 , wherein:the iodizing agent is an iodine cation.11. The method of producing an aromatic iodine compound claim 8 , according to claim 8 , further comprising the steps of:separating a solid reaction product from a reaction solution obtained in the step (a); andrecrystallizing the reaction product thus separated from the reaction solution.12. The method of producing an aromatic iodine compound claim 8 , according to claim 8 , further comprising the step of isolating a reaction product by carrying out distillation process with respect to a reaction solution obtained in the step (a).13. (canceled) This application is a divisional of U.S. patent application Ser. No. 12/530,274 filed on Sep. 8, 2009, which is a 371 of PCT/JP2008/054184 filed on Mar. 7, 2008 and claims priority to Japanese Application No. 2007-061067 filed on Mar. 9, 2007 and Japanese ...

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Номер записи: 20
06-06-2013 дата публикации

PROCESS FOR REGENERATION OF TITANO SILICATE CATALYST

Номер: US20130144075A1
Автор: BORLE Yogesh Laxman, KANAGASABAPATHY Subbareddy, Kapoor Bir, VERMA Arati
Принадлежит: Aditya Birla Science and Technology Co. Ltd.

Titanosilicate catalyst is used in the oxidation reactions such as allylchloride epoxidation, phenol hydroxylation, Cyclohexanone ammoximation. During the reaction the catalyst is deactivated which further decrease in the efficiency of the oxidation reactions. The present invention provides a method for an efficient regeneration of catalyst titanosilicate catalyst at low temperature below 100° C. using a gaseous mixture containing ozone, without isolating the catalyst from the reactor system. 1. A process for activating a deactivated titano silicate catalyst , in a reactor , said process comprising the following steps;i) washing the catalyst bed containing deactivated titano silicate at a temperature range of 20 to 40° C., with a solvent selected from the group consisting of alcohol, ester, ketone, water and aqueous hydrogen peroxide;ii) heating the reactor to a temperature in the range of 50° C. to 100° C., to provide a heated catalyst bed;iii) reacting the heated catalyst in the catalyst bed, with ozone gas under exothermic conditions, said reaction being carried out by feeding a gaseous mixture containing air/oxygen and ozone having ozone content in the range of 2 to 10%, and monitoring the outlet stream of the gas coming out through said bed for ozone seepage, said reaction continued till the ozone content in the outlet stream is at least 0.2%, to provide a regenerated catalyst; andiv) cooling the regenerated catalyst bed first by passing of air/oxygen gas through the said bed followed by washing of the said bed with a solvent selected from the group consisting of alcohol and water, to a temperature in the range of 20 to 40° C.2. The process as claimed in claim 1 , wherein the steps (ii) and (iii) are repeated at least once claim 1 , after cooling of the regenerated catalyst bed by air/oxygen gas in step (iv).3. The process as claimed in claim 1 , wherein the temperature of the heated catalyst bed in the step (ii) is raised to 80° C.4. The process as claimed in ...

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Номер записи: 21
13-06-2013 дата публикации

PROCESS FOR PRODUCING A t-BUTYL PHENOL FROM A C4 RAFFINATE STREAM

Номер: US20130150629A1
Автор: Kirthivasan Nagarajan, Roger D&#39;Souza, Scott Smith
Принадлежит: SI Group Inc

This invention relates to processes for producing various t-butyl phenols, such as 2,6-di-ten-butyl phenol and ortho-tert-butyl phenol, by selectively reacting phenol or a substituted phenol with an isobutylene-containing C 4 raffinate stream. The 2,6-di-ten-butyl phenol and ortho-tert-butyl phenol can be transalkylated to form other ten-butyl phenols, such as para-tert-butyl phenol, 2,4-di-ten-butyl phenol.

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Номер записи: 22
13-06-2013 дата публикации

METHOD FOR PREPARING PHENOLIC COMPOUNDS

Номер: US20130150630A1
Автор: Chang Ying-Hsi, Chen Chih-Ching, Chen Chih-Hao, LEE Hom-Ti, Liu Chiung-Fang, Wan Hou-Peng, Yu Pei-Jung
Принадлежит: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

In an embodiment of the disclosure, a method for preparing a phenolic compound is provided. The method includes providing a lignin depolymerization product, and hydrogenating the lignin depolymerization product under iron oxide and hydrogen gas to prepare a phenolic compound. The prepared phenolic compound is a crude phenolic composition including phenol, methylphenol, dimethylphenol or a combination thereof. 1. A method for preparing a phenolic compound , comprising:providing a lignin depolymerization product; andhydrogenating the lignin depolymerization product under iron oxide and hydrogen gas to prepare a phenolic compound.3. The method for preparing a phenolic compound as claimed in claim 1 , wherein the iron oxide is triiron tetraoxide (FeO).4. The method for preparing a phenolic compound as claimed in claim 1 , wherein the iron oxide has a particle size equal to or less than 5 μm.5. The method for preparing a phenolic compound as claimed in claim 1 , wherein the lignin depolymerization product is hydrogenated at a temperature of 160-360° C.6. The method for preparing a phenolic compound as claimed in claim 1 , wherein the lignin depolymerization product is hydrogenated at a pressure of hydrogen gas of 5-100 atm.7. The method for preparing a phenolic compound as claimed in claim 1 , wherein the lignin depolymerization product is hydrogenated at a space velocity of 10-60 h.8. The method for preparing a phenolic compound as claimed in claim 1 , wherein the phenolic compound is a crude phenolic composition.9. The method for preparing a phenolic compound as claimed in claim 8 , wherein the crude phenolic composition comprises phenol claim 8 , methylphenol claim 8 , dimethylphenol or a combination thereof. This Application claims priority of Taiwan Patent Application No. 100145895, filed on Dec 13, 2011, the entirety of which is incorporated by reference herein.1. Technical FieldThe technical field relates to a method for preparing a phenolic compound from lignin ...

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Номер записи: 23
04-07-2013 дата публикации

"process for producing cycloalkylaromatic compounds"

Номер: US20130172514A1
Автор: Teng Xu, Wenyih F. Lai
Принадлежит: ExxonMobil Chemical Patents Inc

In a process for producing a cycloalkylaromatic compound, an aromatic compound, hydrogen and at least one diluent are supplied to a hydroalkylation reaction zone, such that the weight ratio of the diluent to the aromatic compound supplied to the hydroalkylation reaction zone is at least 1:100. The aromatic compound, hydrogen and the at least one diluent are then contacted under hydroalkylation conditions with a hydroalkylation catalyst in the hydroalkylation reaction zone to produce an effluent comprising a cycloalkylaromatic compound.

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Номер записи: 24
11-07-2013 дата публикации

CRYSTALLIZER AND METHOD FOR PRODUCING PHENOL-BPA ADDUCT CRYSTALS

Номер: US20130178660A1
Автор: FETSKO Stephen W.
Принадлежит: BADGER LICENSING LLC

A method for the evaporative production of phenol-BPA adduct crystals in a crystallizer is provided. First, a supersaturated BPA solution is introduced into a crystallizer that includes a cylindrical vessel and a concentrically-disposed draft tube that defines an annular space between the vessel and tube. Next, the BPA solution is circulated through the draft tube and annular space while a coolant is uniformly distributed in the circulating flow by radially injecting a volatile hydrocarbon compound at between about 30% and 60% of a radial extent of the annular space of to form a BPA mixture. Phenol-BPA adduct crystals are produced in the vessel by evaporating the volatile hydrocarbon compound out of the BPA mixture. The method provides a consistent and uniform concentration of coolant across the surface of the boiling zone that prevents or at least reduces unwanted crystal nucleation. 1. A method of forming phenol-BPA adduct crystals in a crystallizer by evaporative cooling including a cylindrical vessel; a draft tube concentrically disposed within said cylindrical vessel such that an annular space is defined between said vessel and tube , comprisingintroducing a supersaturated BPA solution into said vessel;circulating said BPA solution through said draft tube and annular space;uniformly distributing a coolant in the circulating flow of supersaturated BPA solution to form a BPA mixture by radially injecting said volatile hydrocarbon compound at between about 30% and 60% of a radial extent of said annular space, andproducing phenol-BPA adduct crystals in said vessel by evaporating said volatile hydrocarbon compound out of said BPA mixture.2. The method of claim 1 , wherein said coolant is injected through discharge ends of nozzles that are located at between about 30% and 60% of a radial extent of said annular space and below an upper end of the draft tube a distance of between about 50% to 150% the diameter of said vessel.3. The method of claim 2 , wherein said ...

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Номер записи: 25
25-07-2013 дата публикации

Fluorine Radiolabelling Process

Номер: US20130190529A1
Автор: Gouveneur Veronique, Huiban Mickael, Li Lei, Lim Yee-Hwee
Принадлежит:

The invention relates to a process for producing a process for producing an F-labelled compound, the process comprising treating a compound of formula (I) 4. A process according to wherein said rearomatisation is performed in situ.5. A process according to wherein said rearomatisation comprises the addition of a reagent which effects cleavage of Xfrom the carbon atom of the ring which is para to EDG′ in the compound of formula (IIa) claim 3 , to produce a compound of formula (II) claim 3 , wherein said reagent is an acid claim 3 , base or oxidising agent.613.-. (canceled)1517.-. (canceled)2021.-. (canceled)28. A process according to which further comprises a deprotection step comprising substituting H for said amino protecting group R claim 27 , thereby converting the group —NHRin the compound of formula (IIc″″) or (IId″″) into a —NHgroup.3233.-. (canceled)34. A process according to wherein said rearomatisation is performed in situ.35. A process according to wherein said rearomatisation comprises the addition of a reagent which effects cleavage of Xfrom the carbon atom of the ring which is para to EDG′ in the compound of formula (IIc) or formula (IId) claim 23 , wherein said reagent is an acid claim 23 , base or oxidising agent.3645.-. (canceled)47. A process according to wherein said deprotection step is performed in situ.4851.-. (canceled)52. A process according to wherein the step of treating the compound of formula (I) with [F]fluoride comprises treating the compound of formula (I) with a compound comprising F and a counter cation claim 1 , wherein the counter cation is a quaternary ammonium cation claim 1 , an alkali metal or H.5362.-. (canceled)63. A process according to wherein the oxidant is a hypervalent iodonium (III) reagent or a metal oxide.6466.-. (canceled)67. A process according to wherein the step of treating the compound of formula (I) with [F]fluoride is performed in the presence of an additive claim 1 , wherein the additive is an acid or a crown ...

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Номер записи: 26
08-08-2013 дата публикации

"OXIDATION OF HYDROCARBONS"

Номер: US20130203984A1
Автор: Becker Christopher L., Benitez Franisco M., Dakka Jihad M., Mozeleski Edmund J.
Принадлежит:

In a process for oxidizing a hydrocarbon to a product comprising at least one of the corresponding hydroperoxide, alcohol, ketone, carboxylic acid and dicarboxylic acid, the hydrocarbon is contacted with an oxygen-containing compound in at least one oxidation zone in the presence of a catalyst comprising a cyclic imide having an imide group of formula (I): 2. The process of claim 1 , wherein the oxygen-containing compound is air that has been at least partially dehydrated.3. The process of claim 1 , wherein said hydrocarbon comprises an alkane or cycloalkane.4. The process of claim 1 , wherein said hydrocarbon comprises isobutane or cyclohexane.5. The process of claim 1 , wherein said hydrocarbon comprises cyclohexane claim 1 , the product comprises cyclohexanol and the process further comprises converting the cyclohexanol to adipic acid.6. The process of claim 1 , wherein said hydrocarbon comprises cyclohexane claim 1 , the product comprises cyclohexanone and the process further comprises converting the cyclohexanone to caprolactam.7. The process of claim 1 , wherein said hydrocarbon comprises iso-butane claim 1 , the product comprises tert-butyl hydroperoxide and the process further comprises using the tert-butyl hydroperoxide as an oxidation catalyst.9. The process of claim 8 , wherein said alkylaromatic compound of general formula (II) is selected from ethyl benzene claim 8 , cumene claim 8 , sec-butylbenzene claim 8 , sec-pentylbenzene claim 8 , p-methyl-sec-butylbenzene claim 8 , 1 claim 8 ,4-diphenylcyclohexane claim 8 , sec-hexylbenzene claim 8 , and cyclohexylbenzene.10. The process of claim 8 , and further comprising cleaving the hydroperoxide to produce phenol or a substituted phenol.13. The process of claim 1 , wherein said cyclic imide comprises N-hydroxyphthalimide.14. The process of claim 1 , wherein said oxygen-containing compound supplied to said oxidation zone has a water content of less than or equal to 0.3% by weight of the oxygen-containing ...

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Номер записи: 27
08-08-2013 дата публикации

"CYCLOHEXANONE COMPOSITIONS"

Номер: US20130204045A1
Автор: Benitez Francisco Manuel, Kuechler Keith Holroyd
Принадлежит:

Described herein are compositions having (a) at least 99 wt % cyclohexanone; and (b) 0.1 wppm to 1000 wppm of at least one of cyclohexanedione and hydroxycyclohexanone. The wt % and wppm are based upon the total weight of the composition. The compositions may further comprise 0.1 wppm to 1000 wppm of cyclohexanol. 1. A composition comprising:(a) at least 99 wt % cyclohexanone; and(b) 0.1 wppm to 1000 wppm of at least one of cyclohexanedione and hydroxycyclohexanone, wherein the wt % and wppm are based upon the total weight of the composition.2. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 100 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.3. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 10 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.4. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 1 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.5. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 100 wppm of each one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.6. The composition of claim 1 , wherein the composition comprises 1 wppm to 100 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.7. The composition of claim 1 , wherein the composition comprises 2 wppm to 100 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.8. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 1000 wppm of cyclohexanol claim 1 , based upon the total weight of the composition.9. The composition of claim 1 , wherein the composition comprises 0.1 ...

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Номер записи: 28
08-08-2013 дата публикации

Dehydrogenation Process

Номер: US20130204048A1
Автор: Dakka Jihad M., DeCaul Lorenzo C.
Принадлежит: ExxonMobil Chemical Patents Inc.

In a process for the dehydrogenation of at least one dehydrogenatable hydrocarbon, at least one dehydrogenatable hydrocarbon selected from an oxygen-containing six-membered carbon ring compound is supplied to a first dehydrogenation reaction zone together with at least one stabilizing compound selected from a non-oxygen-containing six membered carbon ring compound to the first dehydrogenation reaction zone, such that the weight ratio of the stabilizing compound to the dehydrogenatable hydrocarbon supplied to the first dehydrogenation reaction zone is in the range of from 1:200 to 200:1. The dehydrogenation feed stream and the at least one stabilizing compound are contacted with a first dehydrogenation catalyst in the first dehydrogenation reaction zone under dehydrogenation conditions to convert at least a portion of the dehydrogenatable hydrocarbon into an unsaturated six-membered carbon ring compound and hydrogen. 1. A process for the dehydrogenation of at least one dehydrogenatable hydrocarbon , the process comprising:(a) supplying a dehydrogenation feed stream comprising at least one dehydrogenatable hydrocarbon to a first dehydrogenation reaction zone wherein the at least one dehydrogenatable hydrocarbon is an oxygen-containing six-membered carbon ring compound;(b) supplying at least one stabilizing compound to the first dehydrogenation reaction zone, such that the weight ratio of the stabilizing compound to the dehydrogenatable hydrocarbon supplied to the first dehydrogenation reaction zone is in the range of from 1:200 to 200:1 wherein the stabilizing compound is a non-oxygen-containing six membered carbon ring compound; and(c) contacting the at least one dehydrogenatable hydrocarbon and the at least one stabilizing compound with a first dehydrogenation catalyst in the first dehydrogenation reaction zone under dehydrogenation conditions to convert at least a portion of the dehydrogenatable hydrocarbon into an unsaturated six-membered carbon ring compound and ...

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Номер записи: 29
15-08-2013 дата публикации

Oxidation of Alkylbenzenes

Номер: US20130211036A1
Автор: Becker Christopher L., Dakka Jihad M., Mozeleski Edmund J., Smith Charles Morris, Zushma Stephen
Принадлежит: ExxonMobil Chemical Company - Law Technology

A process for oxidizing a composition comprising contacting an alkylbenzene of the general formula (I): 2. The process of claim 1 , and further comprising:(c) cleaving at least a portion of the alkylbenzene hydroperoxide produced by the contacting step (b) to produce phenol and cyclohexanone.3. The process of claim 2 , wherein at least a portion of the phenol present in the feed in the composition is provided from a recycle stream from the contacting step (b) and/or the cleaving step (c).4. The process of claim 1 , wherein the composition comprises from about 0.1 wt % to about 1 wt % of phenol based upon total weight of the composition.5. The process of claim 1 , wherein the composition comprises from about 0.15 wt % to about 0.5 wt % of phenol based upon total weight of the composition.6. The process of claim 1 , wherein the alkylbenzene is selected from cumene claim 1 , sec-butylbenzene claim 1 , cyclohexylbenzene and mixtures thereof.8. The process of claim 1 , wherein the cyclic imide comprises N-hydroxyphthalimide.9. The process of claim 1 , wherein the catalyst containing a cyclic imide having the general formula (II) is effective to remove at least a portion of the phenol.10. The process of claim 1 , wherein the cyclic imide is present in an amount of between 0.05 wt % and 5 wt % of the composition.11. The process of claim 1 , wherein the contacting step (b) is conducted at a temperature of between 90° C. and 150° C.12. The process of claim 1 , wherein the contacting step (b) is conducted at a temperature of between 105° C. and 120° C.13. The process of claim 1 , wherein the contacting step (b) is conducted at a pressure between 15 kPa and 500 kPa.14. (canceled)15. The process of claim 2 , wherein at least a portion of the phenol produced in the cleaving step (c) is converted to one or more of a phenolic resin claim 2 , bisphenol A claim 2 , ε-caprolactam claim 2 , an adipic acid claim 2 , or a plasticizer.16. The process of claim 2 , wherein at least a ...

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Номер записи: 30
15-08-2013 дата публикации

Process for the preparation of hydroquinones

Номер: US20130211149A1
Автор: Kadam Shahuraj Hanamantrao, Paknikar Shashikumar
Принадлежит: Merck Patent GmBH

The invention relates to a process for the preparation of a hydroquinone compound of formula (I)

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Номер записи: 31
22-08-2013 дата публикации

SHIP1 MODULATORS AND RELATED METHODS

Номер: US20130217674A1
Автор: Andersen Raymond, Meimetis Labros George, Nodwell Matthew Bruce, Wang Xiaoxia
Принадлежит: The University of British Columbia

Compounds of structure (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R, Rand A are as defined herein are disclosed. Such compounds have enhanced water solubility and have activity as SHIP1 modulators, and thus may be used to treat any of a variety of diseases, disorders or conditions that would benefit from SHIP1 modulation. Enantioselective methods for preparation of compounds of structure (I), compositions comprising a compound of structure (I) in combination with a pharmaceutically acceptable carrier or diluents and methods of SHIP1 modulation by administration of such compounds to an animal in need thereof are also disclosed. 19. A composition comprising a compound of in combination with a pharmaceutically acceptable carrier or diluent.20. A method for modulating SHIP1 comprising administering an effective amount of a composition of to an animal in need thereof.21. A method for treating a disease claim 19 , disorder or condition comprising administering an effective amount of a composition of to an animal in need thereof claim 19 , where the disease claim 19 , disorder or condition is an autoimmune disease claim 19 , disorder or condition claim 19 , an inflammatory disease claim 19 , disorder or condition claim 19 , or a neoplastic or cell proliferative disease claim 19 , disorder or condition.22. The method of wherein the disease claim 21 , disorder or condition is an autoimmune disease claim 21 , disorder or condition selected from idiopathic pulmonary fibrosis claim 21 , an inflammatory bowel disease claim 21 , rheumatoid arthritis claim 21 , Still's Disease claim 21 , Sjögren's Syndrome claim 21 , systemic lupus erythematosus claim 21 , and systemic sclerosis.23. The method of claim 22 , wherein the disease claim 22 , disorder or condition is an inflammatory bowel disease selected from Crohn's Disease and ulcerative colitis.24. The method of wherein the disease claim 21 , disorder or condition is an inflammatory disease ...

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Номер записи: 32
22-08-2013 дата публикации

"PROCESSES FOR PRODUCING PHENOL"

Номер: US20130217921A1
Автор: Benitez Francisco M., Kuechler Keith H.
Принадлежит: ExxonMobil Chemical Patents Inc.

In a process for producing phenol and cyclohexanone, a feed comprising cyclohexylbenzene is oxidized to produce an oxidation reaction product comprising cyclohexyl-1-phenyl-1-hydroperoxide. At least a portion of the oxidation reaction product is then cleaved to produce a cleavage reaction product comprising phenol, cyclohexanone, and at least one contaminant. At least a portion of the cleavage reaction product is contacted with an acidic material to convert at least a portion of the at least one contaminant to a converted contaminant and thereby produce a modified reaction product. 1. A process for producing phenol comprising:(a) oxidizing at least a portion of a feed comprising cyclohexylbenzene to produce an oxidation composition comprising cyclohexyl-1-phenyl-1-hydroperoxide;(b) cleaving at least a portion of the oxidation composition to produce a cleavage reaction mixture comprising phenol, cyclohexanone and at least one contaminant; and(c) contacting at least a portion of the cleavage reaction mixture with an acidic material to convert at least a portion of the contaminant to a converted contaminant, thereby producing a modified reaction mixture.2. The process of claim 1 , wherein the contaminant is one or more of an acyclic aliphatic hexanal claim 1 , an acyclic aliphatic hexanone claim 1 , a cyclohexenone claim 1 , a cyclohexyldione claim 1 , a hydroxycyclohexanone claim 1 , benzoic acid claim 1 , a benzoic ester claim 1 , a cyclohexenyl cyclohexanone claim 1 , a methylcyclopentenyl cyclohexanone claim 1 , 1-phenyl-6-hydroxyhexan-1-one claim 1 , 1-cyclohexyl-6-hydroxyhexan-1-one and a bicyclic twelve carbon hydroperoxide.3. The process of claim 1 , wherein the acidic material comprises at least one of a microporous acid material claim 1 , a cation exchange resin claim 1 , a Bronsted acid claim 1 , and sulfurous acid or acid salt.4. The process of claim 1 , wherein the acidic material is a solid acid catalyst.5. The process of claim 1 , wherein the acidic ...

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Номер записи: 33
22-08-2013 дата публикации

Processes for Producing Phenol

Номер: US20130217922A1
Автор: Becker Christopher L., Benitez Francisco M., Kuechler Keith H., Lattner James R., Wang Kun
Принадлежит:

Disclosed herein is a process for producing phenol. The process includes oxidizing at least a portion of a feed comprising cyclohexylbenzene to produce an oxidation composition comprising cyclohexyl-1-phenyl-1-hydroperoxide. The oxidation composition may then be cleaved in the presence of an acid catalyst to produce a cleavage reaction mixture comprising the acid catalyst, phenol and cyclohexanone. At least a portion of the cleavage reaction mixture may be neutralized with a basic material to form a treated cleavage reaction mixture. In various embodiments, the treated cleavage reaction mixture contains no greater than 50 wppm of the acid catalyst or no greater than 50 wppm of the basic material. 1. A process for producing phenol comprising:(a) oxidizing at least a portion of a feed comprising cyclohexylbenzene to produce an oxidation composition comprising cyclohexyl-1-phenyl-1-hydroperoxide;(b) cleaving at least a portion of the oxidation composition in the presence of an acid catalyst to produce a cleavage reaction mixture comprising the acid catalyst, phenol and cyclohexanone; and(c) neutralizing at least a portion of the cleavage reaction mixture with a basic material to form a treated cleavage reaction mixture, wherein the treated cleavage reaction mixture contains no greater than 50 weight-parts-per-million (wppm) of the acid catalyst or no greater than 50 wppm of the basic material.2. The process of claim 1 , wherein the oxidation composition comprises at least 65 wt % cyclohexylbenzene claim 1 , the wt % based upon the total weight of the oxidation composition.3. The process of claim 1 , wherein the oxidation composition further comprises one or more hydroperoxides selected from cyclohexyl-1-phenyl-2-hydroperoxide; cyclohexyl-1-phenyl-3-hydroperoxide; cyclohexyl-1-phenyl-4-hydroperoxide; cyclopentyl-1-methyl-2-phenyl-2-hydroperoxide; cyclopentyl-1-methyl-3-phenyl-3-hydroperoxide; cyclopentyl-1-methyl-1-phenyl-2-hydroperoxide; cyclopentyl-1-methyl-1-phenyl-3 ...

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Номер записи: 34
29-08-2013 дата публикации

Polycarbonate made from low sulfur bisphenol a and containing converions material chemistry, and articles made therefrom

Номер: US20130221837A1
Автор: Christian Wold, Christopher Luke Hein, Eric BRANDER, Hatem Abdallah Belfadhel, Johannes DE BROUWER, Marcel Vieveen, Thomas L. Evans
Принадлежит: SABIC INNOVATIVE PLASTICS IP BV

In one embodiment, a process for producing a bisphenol A product comprises: reacting phenol with acetone in the presence of a sulfur containing promoter to obtain a reaction mixture comprising bisphenol A, phenol, and the promoter; after reacting the phenol with the acetone, cooling to form a crystal stream comprising crystals of bisphenol A and phenol; separating the crystals from the crystal steam; melting the crystals to form a molten stream of bisphenol A, phenol, and sulfur; contacting the molten stream with a base to reduce a sulfur concentration in the molten stream and form a reduced sulfur stream; and removing phenol from the reduced sulfur stream to form a bisphenol A product.

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Номер записи: 35
29-08-2013 дата публикации

Continuous process for conversion of lignin to useful compounds

Номер: US20130224816A1
Автор: Aaron MURRAY, Dan Gastaldo, Guliz Arf Elliott, Steven RYBA
Принадлежит: Chemtex Italia SpA

This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles.

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Номер записи: 36
29-08-2013 дата публикации

Fluoroalkylation Methods And Reagents

Номер: US20130225815A1
Автор: Hiroyuki Morimoto, John F. Hartwig, Patrick Fier
Принадлежит: University of Illinois

A method of forming a fluorinated molecular entity includes reacting in a reaction mixture an aromatic halide, copper, a fluoroalkyl group, and a ligand. The aromatic halide includes an aromatic group and a halogen substituent bonded to the aromatic group. The ligand includes at least one group-V donor selected from phosphorus and an amine. The overall molar ratio of copper to aromatic halide in the reaction mixture is from 0.2 to 3. The method further includes forming a fluoroalkylarene including the aromatic group and the fluoroalkyl group bonded to the aromatic group. A composition, which may be used in the method, consists essentially of copper, the fluoroalkyl group, and the ligand, where the molar ratio of copper to the fluoroalkyl group is approximately 1.

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Номер записи: 37
29-08-2013 дата публикации

CONTINUOUS PROCESS FOR CONVERSION OF LIGNIN TO USEFUL COMPOUNDS

Номер: US20130225853A1
Автор: Elliott Guliz Arf, Gastaldo Dan, Murray Aaron, Ryba Steven, Sisson Edwin A.
Принадлежит: CHEMTEX ITALIA, S.P.A.

This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles. 1. A process for preparing a slurry comprised of lignin comprising the steps of:a. charging a composition comprised of lignin and at least one slurry liquid at 25° C. to a vessel capable of being subjected to vacuum,b. subjecting the vessel to vacuum for a time sufficient to disperse particles of the composition comprised of lignin to greater than 50% of the theoretical dispersion of the composition comprised of lignin.2. The process according to claim 1 , wherein the slurry liquid comprises water.3. The process according to claim 1 , wherein the slurry liquid comprises a hydrogen donor.4. The process according to claim 1 , wherein the vacuum is defined as a pressure less than atmospheric pressure.5. The process according to claim 4 , wherein the pressure less than atmospheric pressure is in the range of between 0.2 bar and 0.8 bar.6. The process according to claim 1 , wherein the time is sufficient to disperse the particles of lignin to greater than 75% of the theoretical dispersion.7. The process according to claim 1 , wherein the time is sufficient to disperse the particles of lignin to greater than 90% of the theoretical dispersion.8. The process according to claim 1 , wherein the process further comprises the application of mechanical agitation in which the composition comprised of lignin is mechanically mixed with the slurry liquid.9. The process according to claim 8 , ...

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Номер записи: 38
29-08-2013 дата публикации

CONTINUOUS PROCESS FOR CONVERSION OF LIGNIN TO USEFUL COMPOUNDS

Номер: US20130225854A1
Автор: Elliott Guliz Arf, Gastaldo Dan, Moharreri Ehsan, Murray Aaron, Ryba Steven, Sharma Krishna, Sisson Edwin A.
Принадлежит: CHEMTEX ITALIA, S.P.A.

This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles. 1. A continuous process for the conversion of lignin feedstock comprised of lignin and glucans , said process comprising:A. Slurry creation of a slurry comprised of lignin from the lignin feedstock,B. Charging the slurry comprised of lignin into a lignin conversion reactor having a lignin conversion pressure, wherein the pressure of the slurry comprised of lignin is higher than the lignin conversion pressure,C. Converting the lignin of the slurry comprised of lignin into lignin conversion products by contacting the lignin with hydrogen in the presence of a first catalyst at a lignin conversion temperature, andD. Removing the lignin conversion products from the lignin conversion reactor.2. The process of claim 1 , wherein the slurry creation comprises the steps of:a. charging the lignin feedstock comprised of lignin and at least one slurry liquid at 25° C. to a vessel capable of being subjected to vacuum,b. subjecting the vessel to vacuum for a time sufficient to disperse particles of the lignin to greater than 50% of the theoretical dispersion.3. The process of claim 1 , wherein the slurry creation comprises the steps of:a. imparting high shear forces to the lignin feedstock,b. adding a slurry liquid to the lignin feedstock after application of the high shear forces.4. The process of claim 1 , wherein the charging of the slurry comprised of lignin into the lignin conversion ...

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Номер записи: 39
29-08-2013 дата публикации

Continuous process for conversion of lignin to useful compounds

Номер: US20130225855A1
Автор: Aaron MURRAY, Dan Gastaldo, Guliz Arf Elliott, Steven RYBA
Принадлежит: Chemtex Italia SpA

This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles.

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Номер записи: 40
29-08-2013 дата публикации

CONTINUOUS PROCESS FOR CONVERSION OF LIGNIN TO USEFUL COMPOUNDS

Номер: US20130225856A1
Автор: Elliott Guliz Arf, Gastaldo Dan, Murray Aaron, Ryba Steven
Принадлежит: CHEMTEX ITALIA, S.P.A.

This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles. 1. An integrated process for the conversion of a ligno-cellulosic biomass feedstock comprised of lignin and carbohydrates , said process comprising:A. Pretreating the ligno-cellulosic biomass feedstock with treatment water which includes steam explosion to create a pre-treated ligno-cellulosic biomass feedstock,B. Converting at least a portion of the carbohydrates of the pre-treated ligno-cellulosic biomass feedstock into carbohydrate conversion products selected from the group consisting of alcohols, polyols, glucans, gluco-lignins and cellulose,C. Charging the lignin from the ligno-cellulosic biomass feedstock into a lignin conversion reactor having a lignin conversion pressure via a stream comprised of lignin from the ligno-cellulosic biomass feedstock,D. Converting at least a portion of the lignin of the pre-treated ligno-cellulosic biomass feedstock into lignin conversion products by contacting the lignin with hydrogen in the presence of a first catalyst at a lignin conversion temperature,E. Removing the lignin conversion products from the lignin conversion reactor.2. The process according to claim 1 , wherein converting at least a portion of the carbohydrates of the pretreated ligno-cellulosic biomass feedstock to at least one polyol produces a hydrogen donor which is used as a source of hydrogen for converting at least a portion of the lignin of the pre-treated ligno- ...

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Номер записи: 41
29-08-2013 дата публикации

METHOD OF SYNTHESIZING SUBSTITUTED 2-ALKYL PHENOLS

Номер: US20130225870A1
Автор: Bloom Steven, Lee Chi-Wan
Принадлежит: Synta Pharmaceuticals Corp.

Methods of synthesizing 4-alkyl resorcinols and other substituted phenol compounds, according to formula (IV): or salts thereof, are disclosed, wherein the variables are defined herein. 153.-. (canceled)61. The method of or , wherein the organic solvent has a boiling point of about 100° C. or above.62. The method of claim 61 , wherein the organic solvent is selected from xylene claim 61 , toluene claim 61 , an alcohol claim 61 , DMA claim 61 , DME claim 61 , NMP claim 61 , DMF claim 61 , ethylene glycol claim 61 , and diethylene glycol.63. The method of or claim 61 , wherein the base is NaOH or KOH.64. The method of or claim 61 , wherein the base is NaOH claim 61 , the organic solvent is DMF claim 61 , and the reaction temperature is about 110° C.65. The method of or claim 61 , wherein the double bond is reduced by a hydrogenation procedure.66. The method of claim 65 , wherein the hydrogenation is done using Pd/C and a source of hydrogen.67. The method of claim 66 , wherein the source of hydrogen is hydrogen gas.68. The method of claim 66 , wherein the source of hydrogen is NHCOH.69. The method of or claim 66 , wherein the reaction is a Vilsmeire-Haack reaction; and wherein Y is O; and Ris H for the compound of Formula (IV).70. The method of claim 60 , wherein the reaction is a Vilsmeire-Haack reaction.71. The method of or claim 60 , wherein the reaction is run at a temperature range of about −10° C. to about 5° C.72. The method of or claim 60 , wherein the reaction is performed using POClin DMF in an inert atmosphere. Resorcinol and its derivatives have a wide variety of applications, from the cosmetic industry to pharmaceuticals. Commonly, contract vendors for synthesizing 4-isoalkyl resorcinols use methods such as disclosed in WO 04/52814 (Unilever). However, this method produces five side products and is expensive. In order to isolate the desired 4-isoalkyl resorcinol from the side products produced by these methods, a complicated and expensive purification ...

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Номер записи: 42
12-09-2013 дата публикации

Method for tiered production of biobased chemicals and biofuels from lignin

Номер: US20130232852A1
Автор: Benjamin M.T. Scott, John R. Peterson, Vladimir Romakh
Принадлежит: Thesis Chemistry LLC

The present invention is directed generally to a method of production of value-added, biobased chemicals from lignin sources, including waste lignin. A method of using a depolymerization of lignin to create a tiered production of biobased aromatic chemicals and biofuels is also described herein. The method described herein may also allow for the selective production of the biobased aromatic chemicals and biofuels. Additionally, a reduction of waste products may also be provided from the present method.

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Номер записи: 43
03-10-2013 дата публикации

Compounds and methods for kinase modulation, and indications therefor

Номер: US20130261117A1
Автор: Chao Zhang, Gideon Bollag, Jianming Tsai, Jiazhong Zhang, Klaus-Peter Hirth, Prabha N. Ibrahim, Wayne Spevak
Принадлежит: Plexxikon Inc

Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

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Номер записи: 44
03-10-2013 дата публикации

INTEGRATED METHODS OF PREPARING RENEWABLE CHEMICALS

Номер: US20130261323A1
Автор: Al Obaidi Yassin, Griffith Josefa M., Gruber Patrick R., Henton David E., Manzer Leo E., Peters Matthew W., Taylor Joshua D.
Принадлежит: GEVO, INC.

Isobutene, isoprene, and butadiene are obtained from mixtures of Cand/or Colefins by dehydrogenation. The Cand/or Colefins can be obtained by dehydration of Cand Calcohols, for example, renewable Cand Calcohols prepared from biomass by thermochemical or fermentation processes. Isoprene or butadiene can be polymerized to form polymers such as polyisoprene, polybutadiene, synthetic rubbers such as butyl rubber, etc. in addition, butadiene can be converted to monomers such as methyl methacrylate, adipic acid, adiponitrile, 1,4-butadiene, etc. which can then be polymerized to form nylons, polyesters, polymethylmethacrylate etc. 1. An integrated process for preparing renewable hydrocarbons , comprising:(a) providing renewable isobutanol and renewable ethanol;(b) dehydrating the renewable isobutanol, thereby forming a renewable butene mixture comprising one or more renewable linear butenes and renewable isobutene;(c) dehydrating the renewable ethanol, thereby forming renewable ethylene; and{'sub': 3', '16, '(d) reacting at least a portion of the renewable butene mixture and at least a portion of the renewable ethylene to form one or more renewable C-Colefins.'}257-. (canceled)58. The integrated process of claim 1 , wherein the one or more renewable linear butenes comprise one or more of 1-butene claim 1 , cis-2-butene or trans-2-butene.59. The integrated process of claim 1 , wherein said reacting of step (d) comprises one or more reactions selected from the group consisting of disproportionation claim 1 , metathesis claim 1 , oligomerization claim 1 , isomerization claim 1 , alkylation claim 1 , dehydrodimerization claim 1 , dehydrocyclization claim 1 , and combinations thereof.60. The integrated process of claim 1 , wherein said reacting of step (d) comprises disproportionating at least a portion of the renewable ethylene formed in step (c) claim 1 , and at least a portion of the renewable 2-butene formed in step (b) and renewable 2-butene formed by isomerizing the ...

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Номер записи: 45
10-10-2013 дата публикации

PROCESS FOR THE PREPARATION OF BENZYLBENZENE SGLT2 INHIBITORS

Номер: US20130267694A1
Автор: Lv Binhua, Roberge Jacques Y., Seed Brian, Xu Baihua, XU Ge
Принадлежит: Theracos, Inc.

Provided are methods of making compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides synthetic intermediates useful for preparing such compounds. 3. The method of claim 1 , wherein{'sup': '2', 'Ris H;'}{'sup': '3', 'sub': 1', '6', '1', '3', '1', '3', '1', '3', '3', '6', '3', '6', '1', '3, 'Ris selected from the group consisting of C-Calkyl, C-Calkoxy, (C-Calkoxy)C-Calkoxy, C-Ccycloalkyl, and (C-Ccycloalkoxy)C-Calkoxy; and'}{'sup': '4', 'sub': 1', '3, 'Ris selected from the group consisting of H, OH and C-Calkoxy.'}4. The method of claim 1 , wherein Ris selected from the group consisting of C-Calkoxy claim 1 , C-Ccycloalkyl claim 1 , and (C-Ccycloalkoxy)C-Calkoxy.5. The method of claim 1 , wherein Ris selected from the group consisting of ethoxy claim 1 , cyclopropyl and 2-cyclopropoxyethoxy.6. The method of claim 1 , wherein Ris OH.7. The method of claim 1 , wherein{'sup': '2', 'Ris H;'}{'sup': '3', 'Ris selected from the group consisting of ethoxy, cyclopropyl and 2-cyclopropoxyethoxy; and'}{'sup': '4', 'Ris OH.'}8. The method of claim 1 , wherein the ratio of the alkyl-magnesium complex in step (a) to the compound of Formula II is from about 0.95 up to 1.0 (mol/mol).9. The method of claim 1 , wherein the first reaction mixture further comprises an accelerating agent selected from the group consisting of LiCl claim 1 , ZnCl claim 1 , diisobutylaluminum hydride claim 1 , sodium bis(2-methoxyethoxy)aluminum hydride claim 1 , tri-methylsilyl chloride claim 1 , and 2 claim 1 ,2′-oxybis(N claim 1 ,N-dimethylethanamine).10. The method of claim 9 , wherein the first reaction mixture further comprises LiCl.11. The method of claim 9 , wherein the ratio of the accelerating agent to the alkyl-magnesium complex is about 1.0 (mol/mol).12. The method of claim 1 , wherein the first reaction mixture is at a temperature of from about −60 to about −50° C.13. The method of claim 1 , wherein the second reaction mixture ...

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Номер записи: 46
17-10-2013 дата публикации

HYDROGENATION OF ESTERS OR CARBONYL GROUPS WITH TETRADENTATE AMINO/IMINO-THIOETHER BASED RUTHENIUM COMPLEXES

Номер: US20130274487A1
Автор: Santoro Francesco, Saudan Christophe, Saudan Lionel
Принадлежит: FIRMENICH SA

The present invention relates to the field of catalytic hydrogenation and, more particularly, to the use of specific ruthenium catalysts, or pre-catalysts, in hydrogenation processes for the reduction of ketones and/or aldehydes into the corresponding alcohol respectively. Said catalysts are ruthenium complexes comprising a tetradentate ligand (L4) coordinating the ruthenium with: two nitrogen atoms, each in the form of a primary or secondary amine (i.e. a NHor NH group) or N-alkyl imine functional groups (i.e. a C═N group), and two sulfur atoms, each in the form of thioether functional groups. 1. A process for the reduction by hydrogenation , using molecular H , of a C-Csubstrate containing one , two or three ketones and/or aldehydes functional groups into the corresponding alcohol , characterized in that said process is carried out in the presence of at least a base and at least one catalyst or pre-catalyst in the form of a C-Cruthenium complex comprising in the coordination sphere a tetradentate ligand (L4) coordinating the ruthenium with:{'sub': '2', 'two nitrogen atoms, each in the form of a primary or secondary amine (i.e. a NHor NH group) or N-alkyl imine functional groups (i.e. a C═N group), and'}two sulfur atoms, each in the form of thioether functional groups.4. A process according to claim 1 , characterized in that said base is a Calkoxide claim 1 , an alkaline or alkaline-earth hydroxide claim 1 , or an inorganic hydride.5. A process according to claim 1 , characterized in that said ruthenium complex is of formula{'br': None, 'sub': 2-r', 'r', '2-r, '[Ru(L4)(L)Y](Z)\u2003\u2003(1)'}wherein r represents 0, 1 or 2;{'sub': '10-40', 'claim-text': [{'sub': '2', 'two nitrogen atoms, each in the form of a primary or secondary amine (i.e. a NHor NH group) or N-alkyl imine functional groups (i.e. a C═N group), and'}, 'two sulfur atoms, each in the form of thioether functional groups; and, 'L4 represents one Ctetradentate ligand coordinating the Ru metal with{'sub ...

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Номер записи: 47
17-10-2013 дата публикации

Oxidation of Alkylaromatic Compounds

Номер: US20130274524A1
Автор: Dakka Jihad M., Stanat Jon E.R., Zushma Stephen
Принадлежит:

In a process for oxidizing an alkylaromatic compound to the corresponding hydroperoxide, a feed comprising an alkylaromatic compound is contacted with an oxygen-containing gas in the presence of a catalyst comprising a cyclic imide. The contacting is conducted at a temperature of about 90° C. to about 150° C., with the cyclic imide being present in an amount between about 0.05 wt % and about 5 wt % of the alkylaromatic compound in the feed and the catalyst being substantially free of alkali metal compounds. The contacting oxidizes at least part of the alkylaromatic compound in said feed to the corresponding hydroperoxide. 3. The process of claim 1 , wherein said cyclic imide comprises N-hydroxyphthalimide.4. The process of claim 1 , wherein said contacting is conducted at a temperature of between about 125° C. and about 140° C. and a pressure of about 15 kPa to about 150 kPa.5. The process of claim 1 , wherein said cyclic imide is present in an amount between about 0.1 wt % and about 1 wt % of the alkylaromatic in said feed during said contacting.6. The process of claim 1 , wherein said cyclic imide is present in an amount between about 0.05 wt % and about 0.5 wt % of the alkylaromatic in said feed during said contacting.7. The process of claim 1 , wherein said contacting converts at least 4 wt % per hour conversion of said alkylaromatic compound with a selectivity to the corresponding alkylaromatic hydroperoxide of at least 90 wt %.8. The process of claim 1 , wherein said alkylaromatic compound is cyclohexylbenzene.9. The process of claim 1 , further comprising the step of:cleaving the alkylaromatic hydroperoxide to produce phenol and the corresponding ketone.10. The process of claim 9 , wherein the cleaving is conducted in the presence of a catalyst.11. The process of claim 9 , wherein the cleaving is conducted in the presence of a homogeneous catalyst.12. The process of claim 11 , wherein said homogeneous catalyst comprises at least one of sulfuric acid claim 11 ...

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Номер записи: 48
24-10-2013 дата публикации

Method for Cultivation of Monarda Fistulosa for Production of Thymoquinone

Номер: US20130281740A1
Автор: William G. Rohlfsen
Принадлежит: PRAIRIE PHARMS LLC

A method for cultivating Monarda fistulosa for production of thymoquinone includes planting seeds at rates between about 2.5 and about 5 pounds per acre, preferably about 4 pounds per acre. The heavy rate of planting produces plants bearing oil without weed contamination and reduces herbicide use due to production of natural herbicides by the monarda plants. Seeding and mowing the first season, and harvesting in seasons thereafter reduce costs. The method results in increased production of essential oils including thymoquinone and thymohydroquinone at levels up to about 5% of recovered oils, and which may be distilled from the plant.

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Номер записи: 49
07-11-2013 дата публикации

PROCESS FOR PRODUCTION OF HYDROXYSTILBENE DERIVATIVE HAVING PHYSIOLOGICAL ACTIVITY

Номер: US20130296613A1
Автор: Doi Satoshi, Kishi Akinobu, Matsui Takeki, Matsukawa Taiji, Yamada Ichiro, Yamada Yasumasa
Принадлежит: UHA MIKAKUTO CO., LTD.

A process for producing a hydroxystilbene derivative represented by formula (1) (wherein X-Xindependently represent a hydrogen atom, a hydroxy group, a saturated or unsaturated linear or branched alkoxy group having 1-10 carbon atoms, or a saturated or unsaturated linear or branched alkyl group having 1-10 carbon atoms; Zand Zindependently represent a hydrogen atom, or a group represented by the formula (2) (wherein Xand Xindependently represent a hydrogen atom, a hydroxy group, a saturated or unsaturated linear or branched alkoxy group having 1-10 carbon atoms, or a saturated or unsaturated linear or branched alkyl group having 1-10 carbon atoms); and Zand Zmay be the same as or different from each other; wherein X-Xmay be the same as or different from one another), which is characterized by heating a 4-hydroxycinnamic acid compound and a hydroxystilbene compound in the presence of a metal salt. 3. The process according to claim 2 , wherein the 4-hydroxycinnamic acid compounds are one or more kinds of compounds selected from a group consisting of p-coumaric acid claim 2 , ferulic acid claim 2 , caffeic acid claim 2 , sinapic acid claim 2 , di-t-butyl hydroxycinnamic acid compound claim 2 , and artepillin C.5. The process according to claim 4 , wherein the hydroxystilbenes are one or more kinds of compounds selected from a group consisting of resveratrol claim 4 , piceatannol claim 4 , and pterostilbene.6. The process according to claim 1 , wherein the 4-hydroxycinnamic acid compounds are one or more kinds of compounds selected from the group consisting of p-coumaric acid claim 1 , ferulic acid claim 1 , caffeic acid claim 1 , sinapic acid claim 1 , di-t-butyl hydroxycinnamic acid compound claim 1 , and artepillin C claim 1 , and the hydroxystilbenes are one or more kinds of compounds selected from the group consisting of resveratrol claim 1 , piceatannol claim 1 , and pterostilbene.13. The process according to claim 1 , comprising performing heat treatment at 90° C ...

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Номер записи: 50
07-11-2013 дата публикации

Dehydrogenation Processes and Phenol Compositions

Номер: US20130296614A1
Автор: Benitez Francisco M., Kuechler Keith H.
Принадлежит: ExxonMobil Chemical Patents Inc.

Described herein is a process for producing phenol in which (a) benzene and hydrogen are contacted with a hydroalkylation catalyst under hydroalkylation conditions to produce cyclohexylbenzene; (b) the cyclohexylbenzene is contacted with an oxidation catalyst under oxidation conditions to produce cyclohexylbenzene hydroperoxide; (c) the cyclohexylbenzene hydroperoxide is contacted with a cleavage catalyst under cleavage conditions to produce a cleavage effluent comprising phenol and cyclohexanone; (d) the cyclohexanone is contacted with a dehydrogenation catalyst under dehydrogenation conditions to produce a dehydrogenation effluent having at least a portion of the cyclohexanone and a first contaminant; and (e) the first contaminant is contacted with an acidic material under contaminant treatment conditions to convert at least a portion of the first contaminant into a converted first contaminant. Phenol compositions made from the above-described process are also described herein. 1. A process for producing phenol comprising:(a) contacting benzene and hydrogen with a hydroalkylation catalyst under hydroalkylation conditions to produce cyclohexylbenzene;(b) contacting at least a portion of the cyclohexylbenzene with an oxidation catalyst under oxidation conditions to produce cyclohexylbenzene hydroperoxide;(c) contacting at least a portion of the cyclohexylbenzene hydroperoxide with a cleavage catalyst under cleavage conditions to produce a cleavage effluent comprising phenol and cyclohexanone;(d) contacting at least a portion of the cyclohexanone from the cleavage effluent with a dehydrogenation catalyst under dehydrogenation conditions to produce a dehydrogenation effluent having at least a portion of the cyclohexanone converted to phenol, wherein the dehydrogenation effluent further comprises a first contaminant; and(e) contacting at least a portion of the first contaminant from the dehydrogenation effluent with an acidic material under contaminant treatment ...

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Номер записи: 51
14-11-2013 дата публикации

Method of producing biphenolic compound, novel biphenyl compound and synthesis method thereof, and pharmaceutical composition for treating parkinson's disease

Номер: US20130303788A1
Автор: Chinpiao Chen, Hwei-Hsien Chen, Ming-Huan Chan
Принадлежит: Tzu Chi Univ

A method of producing honokiol and analogues thereof, and novel intermediates prepared by virtue thereof are disclosed herein. A pharmaceutical composition for treating Parkinson's disease, which contains honokiol and/or the analogues thereof, is also disclosed herein.

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Номер записи: 52
21-11-2013 дата публикации

PROCESS FOR PRODUCTION OF PHENOLIC POLYMERIZABLE COMPOUND HAVING PHYSIOLOGICAL ACTIVITY

Номер: US20130310611A1
Автор: Doi Satoshi, Kishi Akinobu, Matsui Takeki, Matsukawa Taiji, Yamada Ichiro, Yamada Yasumasa
Принадлежит: UHA MIKAKUTO CO., LTD.

A process for producing a phenolic polymerizable compound represented by formula (1) or (2); wherein X-Xindependently represent a hydrogen atom, a hydroxy group, a saturated or unsaturated linear or branched alkoxy group having 1-10 carbon atoms, or a saturated or unsaturated linear or branched alkyl group having 1-10 carbon atoms; Y represents a hydrogen atom, a hydroxy group, a saturated or unsaturated linear or branched alkoxy group having 1-10 carbon atoms, a saturated or unsaturated linear or branched alkyl group having 1-10 carbon atoms, or a group represented by formula (6); and Z represents a hydrogen atom or a group represented by formula (3), which is characterized by heating a 4-hydroxycinnamic acid compound in the presence of a metal salt. 3. The process according to claim 2 , wherein the 4-hydroxycinnamic acid compounds are one or more kinds of compounds selected from a group consisting of p-coumaric acid claim 2 , ferulic acid claim 2 , coffeic acid claim 2 , sinapic acid claim 2 , di-t-butyl hydroxycinnamic acid compound claim 2 , and artepillin C.10. The process according to claim 1 , comprising performing heat treatment at 90° C. to 150° C.11. An anticancer agent claim 1 , comprising a phenolic polymerizable compound produced by the process according to .12. An anticancer agent to oral cancer claim 1 , comprising a phenolic polymerizable compound produced by the process according to .13. A lipase inhibitor claim 1 , comprising a phenolic polymerizable compound produced by the process according to .14. An anti-obesity agent claim 1 , comprising a phenolic polymerizable compound produced by the process according to .15. A skin disease therapeutic agent claim 1 , comprising a phenolic polymerizable compound produced by the process according to .16. A food claim 1 , a pharmaceutical agent claim 1 , a quasi-drug claim 1 , or cosmetics claim 1 , comprising a phenolic polymerizable compound produced by the process according to . The present invention ...

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Номер записи: 53
28-11-2013 дата публикации

INTERMEDIATES FOR THE SYNTHESIS OF BENZINDENE PROSTAGLANDINS AND PREPARATIONS THEREOF

Номер: US20130317245A1
Автор: HSU Min-Kuan, HSU Ming-Kun, WEI Shih-Yi
Принадлежит: CHIROGATE INTERNATIONAL INC.

Novel processes for preparing optically active cyclopentanones 1 2. A process according to claim 1 , wherein M is phenyl or 4-phenylphenyl. This application is a divisional of U.S. patent application Ser. No. 13/216,378 filed Aug. 24, 2011.1. Field of the InventionThe present invention relates to novel processes for preparing cyclopentanones of Formula 1,which are useful for the preparation of benzindene Prostaglandins. The invention also relates to novel cyclopentanones prepared from the processes.2. Description of the Prior ArtFlolan (Epoprostenol) is the first drug approved by Food and Drug Administration for the treatment of pulmonary hypertension. However, Epoprostenol is extremely unstable and normally has a half-life of about 3˜5 minutes and needs to be administered via continuous intravenous administration and be stored at lower temperatures. Benzindene Prostaglandins, such as UT15 (Treprostinil), are derivatives of Epoprostenol and are a new class of drugs for the treatment of pulmonary hypertension. Benzindene prostaglandins are more stable and thus more convenient and safer in utilization as compared to Epoprostenol.As shown in Scheme 1, cyclopentanones of Formula 1a are important intermediates for the synthesis of benzindene prostaglandins, such as UT15 (Tetrahedron Letters (1982), 23(20), 2067-70):However, as shown in Scheme 2, the synthesis of cyclopentanones of Formula 1a should be started with the intermediate B and undergoes eight steps (43, No. 11, 1978), and would involve more than 20 chemical steps, including the steps for the synthesis of the intermediate B. Such synthesis is very complicated and only achieves a low yield.Consequently, there is a demand in the industry for processes for the preparation of cyclopentanones of Formula 1 and benzindene prostaglandins that involve less steps and are more convenient to operate.The present invention provides novel processes of preparing optically active cyclopentanones 1 and novel cyclopentanones.The ...

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Номер записи: 54
12-12-2013 дата публикации

CHRYSOPHAENTIN ANALOGS THAT INHIBIT FTSZ PROTEIN

Номер: US20130331460A1
Автор: Bewley Carole A., Wipf Peter
Принадлежит:

Embodiments of antimicrobial chrysophaentin compounds, pharmaceutical compositions including the chrysophaentin compounds, methods for using the chrysophaentin compounds, and methods for synthesizing the chrysophaentin compounds are disclosed. Certain embodiments of the chrysophaentin compounds inhibit FtsZ protein, thereby inhibiting the growth of clinically relevant bacteria, including drug-resistant strains. 2. The compound of claim 1 , wherein the compound has formula IX claim 1 , and wherein each Ris hydroxyl claim 1 , Rand Rindependently are halogen claim 1 , Ris hydrogen or halogen claim 1 , and at least one of R claim 1 , R claim 1 , and Ris hydrogen.3. The compound of claim 1 , wherein the compound has formula VII or VIII claim 1 , and wherein each Ris hydroxyl claim 1 , Rand Rindependently are halogen claim 1 , Ris hydrogen or halogen claim 1 , and each Ris ═CH.6. A pharmaceutical composition claim 1 , comprising a pharmaceutically acceptable carrier and a therapeutically effective amount of at least one compound of or a pharmaceutically acceptable salt claim 1 , hydrate claim 1 , or solvate thereof claim 1 , wherein the pharmaceutical composition is capable of inhibiting bacterial cell growth when applied to a bacterium.7. The pharmaceutical composition of claim 6 , further comprising a therapeutically effective amount of a second agent other than the compound.8. The pharmaceutical composition of claim 7 , wherein the second agent is an antimicrobial agent.9. The pharmaceutical compound of claim 8 , wherein the second agent is effective against Gram-negative bacterial cells.10. The pharmaceutical composition of claim 7 , wherein the second agent increases penetration of the compound into the bacterium.11. A method of inhibiting bacterial cell growth claim 1 , comprising exposing a bacterium to an effective amount of a composition comprising a compound of or a pharmaceutically acceptable salt claim 1 , hydrate claim 1 , or solvate thereof.12. The method of ...

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Номер записи: 55
26-12-2013 дата публикации

Reduction of c-0 bonds by catalytic transfer hydrogenolysis

Номер: US20130345445A1
Автор: Anna Lundstedt, Joseph Samec, Supaporn SAWADJOON
Принадлежит: KAT2BIZ AB

The present invention relates to a method of reducing a C—O bond to the corresponding C—H bond in a substrate which could be a benzylic alcohol, allylic alcohol, ester, or ether or an ether bond beta to a hydroxyl group or alpha to a carbonyl group.

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Номер записи: 56
30-01-2014 дата публикации

OLEFIN CONDITIONING IN A FAST CATALYTIC PYROLYSIS RECYCLE PROCESS

Номер: US20140031583A1
Автор: Mazanec Terry, Norenberg Greg, Pesa Fred, Whiting Jeff
Принадлежит:

This invention relates to improvements in the fast pyrolysis of biomass. In this invention, olefins are separated from the effluent stream of a pyrolysis reactor and at least a portion of the olefins are treated and the resulting treated stream recycled to the pyrolysis reactor for further conversion to valuable, useful products. 1. A method for producing one or more fluid hydrocarbon products from a hydrocarbonaceous material , comprising:feeding a hydrocarbonaceous material is fed to a reactor;pyrolyzing at least a portion of the hydrocarbonaceous material within the reactor under reaction conditions sufficient to produce one or more pyrolysis products;separating the products into at least a first fraction and a second fraction, where the first fraction comprises at least one olefin;treating the first fraction by adding a chemical compound and/or reacting at least some of the olefins in the first fraction to produce a treated fraction; andadding the treated fraction to a pyrolysis reactor.2. The method of wherein the treated fraction is recycled to the same reactor that produced the pyrolysis products.3. The method of wherein the step of treating comprises one or any combination of the following steps: conversion of olefins to alcohols or ethers; addition of radical inhibiting agents; low temperature (80-400° C.) polymerization of olefins;reaction with CO to form carboxylic acids; alkylation to form alkylated aromatics, and hydrogenation of alkynes to olefins.4. The method of wherein a gaseous product stream from the reactor is separated into an olefin poor and olefin rich stream claim 1 , and at least a portion of the olefin rich stream coming from an olefins separator is treated before mixing with a full recycle gas stream claim 1 , thereby reducing the volume to be treated.5. The method of wherein one or more fluid hydrocarbon products are produced from the pyrolysis products by a treatment selected from the group consisting of dehydration claim 1 , ...

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Номер записи: 57
27-02-2014 дата публикации

SULFONATED CARBON SILICA COMPOSITE MATERIAL AND A PROCESS FOR THE PREPARATION THEREOF

Номер: US20140057778A1
Автор: NANDAN DEVAKI, VISWANADHAM NAGABHATLA
Принадлежит: COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH

The present invention relates to a novel sulfonated carbon silica (SCS) composite material and a process for the preparation thereof. The synthesized SCS composite material on calcination yields the hierarchical mesoporous silica (MS) and further finds application as catalyst in two industrially important reactions namely phenol butylation and glycerol acetalization. 16.-. (canceled)7. A process of preparing a Sulfonated carbon silica (SCS) composite comprising:(a) gradually mixing a saccharide with a silica source and a sulfuric acid to form a reaction mixture, wherein a ratio between saccharide and the silica source is in the range of about 0.385 to about 4.25 and a quantity of the sulphuric acid is in the range of 0.234 to 1.020 M;(b) allowing a hydrolyzing reaction to progress in the mixture reaction by maintaining the reaction mixture at a temperature in the range of about 298 K to 320 K for a period in the range of about 2 to about 5 hours to effect hydrolyzation thereby to obtain a gel;(c) treating the gel thus obtained in step (b) at a temperature in the range of about 350 K to about 423 K for a period in the range of about 12 hours to about 18 hours to obtain a bulk solid mass; and(d) heating the bulk solid mass as obtained in (c) at a temperature in range of about 473 K to about 573 K for a period in the range of about 4 hours to about 8 hours under nitrogen gas to obtain the sulfonated carbon silica (SCS) composite.8. The process according to claim 7 , wherein step (c) comprises treating the gel as obtained in step (b) inside a Teflon-lined autoclave at a temperature in the range of about 350 K to about 423 K for a period in the range of about 12 hours to about 18 hours to obtain bulk solid mass.9. The process according to claim 7 , further comprising washing the sulfonated carbon silica composite at least once.10. The process according to claim 9 , further comprising drying the sulfonated carbon silica composite.11. The process according to claim 9 , ...

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Номер записи: 58
27-02-2014 дата публикации

SYSTEM FOR FLUORINATING ORGANIC COMPOUNDS

Номер: US20140058106A1
Автор: Furuya Takeru, Kaiser Hanns M., Ritter Tobias
Принадлежит:

Described herein are fluorinated organic compounds and methods of making fluorinated organic compounds, for example, using palladium complexes. Also described herein are compositions and kits containing compounds and palladium complexes described herein. 2. The palladium complex of claim 1 , wherein the palladium complex further comprises a negatively charged counterion X claim 1 , wherein X is selected from BF claim 1 , BPh claim 1 , PF claim 1 , [BArF] claim 1 , B(CF) claim 1 , SbF claim 1 , and CFSO.3. The palladium complex of claim 1 , wherein Z is —N(R)—.4. The palladium complex of claim 3 , wherein Ris —S(O)R.5. The palladium complex of claim 4 , wherein Ris optionally substituted aryl.7. The palladium complex of claim 1 , wherein Ris pyridyl.8. The palladium complex of claim 1 , wherein Ris halogen claim 1 , an optionally substituted heteroaryl claim 1 , or —OR.9. The palladium complex of claim 8 , wherein Ris —Cl or pyridyl.10. The palladium complex of claim 1 , wherein Ris —C(═O)Ror —S(O)R.11. The palladium complex of claim 10 , wherein Ris an optionally substituted aliphatic.12. The palladium complex of claim 11 , wherein Ris —C(═O)CHor —S(O)CF.15. The method of claim 14 , wherein the organic compound comprises an aryl group.16. The method of claim 14 , wherein the organic compound comprises a boron substituent.18. The method of claim 14 , wherein the fluorinating agent provides a source of F.20. The palladium complex of claim 19 , wherein Ris pyridyl.21. The palladium complex of claim 19 , wherein Ris halogen claim 19 , an optionally substituted heteroaryl claim 19 , or —OR.22. The palladium complex of claim 21 , wherein Ris —Cl or pyridyl.23. The palladium complex of claim 21 , wherein Ris —C(═O)Ror —S(O)R.24. The palladium complex of claim 23 , wherein Ris an optionally substituted aliphatic.25. The palladium complex of claim 24 , wherein Ris —C(═O)CHor —S(O)CF. The present application is a Continuation of U.S. application Ser. No. 12/865,703, which is ...

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Номер записи: 59
06-03-2014 дата публикации

Dehydrogenation Catalyst and Process

Номер: US20140066663A1
Автор: Dakka Jihad M., DeCaul Lorenzo C., Helton Terry E., Kuechier Keith H., Waliace Jenna L.
Принадлежит: ExxonMobil Chemical Patents Inc.

A catalyst composition comprises (i) a support; (ii) a dehydrogenation component comprising at least one metal or compound thereof selected from Groups 6 to 10 of the Periodic Table of Elements; and (iii) tin or a tin compound, wherein the tin is present in an amount of 0.01 wt % to about 0.25 wt %, the wt % based upon the total weight of the catalyst composition. 1. A catalyst composition comprising: (i) a support; (ii) a dehydrogenation component comprising at least one metal or compound thereof selected from Groups 6 to 10 of the Periodic Table of Elements; and (iii) tin or a tin compound , wherein the tin is present in an amount of 0.01 wt % to about 0.25 wt % , the wt % based upon the total weight of the catalyst composition.2. The catalyst composition of claim 1 , wherein the tin is present in an amount of about 0.05 wt % to about 0.25 wt % claim 1 , based upon the total weight of the catalyst composition.3. The catalyst composition of claim 1 , wherein the tin is present in an amount of about 0.05 wt % to about 0.15 wt % of tin based upon the total weight of the catalyst composition.4. The catalyst composition of claim 1 , wherein the support is selected from the group consisting of silica claim 1 , a silicate claim 1 , an aluminosilicate claim 1 , zirconia claim 1 , carbon claim 1 , and carbon nanotubes.5. The catalyst composition of claim 1 , wherein the dehydrogenation component comprises at least one of platinum claim 1 , palladium and compounds thereof.6. The catalyst composition of claim 1 , wherein the dehydrogenation component is present in an amount of greater than 0.01 wt % to about 2 wt % claim 1 , based upon the total weight of the catalyst composition.7. The catalyst composition of claim 1 , wherein the composition provides a reduced selectivity to one or more of pentane claim 1 , pentene and carbon monoxide.8. A method for preparing a catalyst composition claim 1 , the method comprising:(a) treating a support with tin or a compound thereof;(b) ...

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Номер записи: 60
13-03-2014 дата публикации

Method for hydroxylating phenols and phenol ethers

Номер: US20140073818A1
Автор: Bigouraux Jean-Christophe, Garel Laurent, NORMAND Stephanie, PITIOT Pascal
Принадлежит: Rhodia Operations

A method for hydroxylating phenols and phenol ethers using hydrogen peroxide and specifically, a method for hydroxylating phenol using hydrogen peroxide. The method for hydroxylating a phenolic substrate selected from a phenol or a phenol ether by reacting such phenolic substrate with hydrogen peroxide in the presence of an acid catalyst comprises the following steps, implemented consecutively or simultaneously: a first step consisting of mixing a phenolic substrate with a hydrogen peroxide solution under conditions in which the temperature is sufficient for the initial phenolic substrate to remain liquid and for minimizing the conversion rate of the hydrogen peroxide; a second step consisting of carrying out the phenolic substrate hydroxylation reaction under adiabatic conditions, the acid catalyst being added at the mixing stage and/or at the beginning of the hydroxylation reaction; and a third step, if necessary, consisting of recovering the hydroxylated product. 1. A process for hydroxylating a phenol or a phenol ether , by reacting said phenol or phenol ether with hydrogen peroxide , in the presence of an acid catalyst , said process comprising the following steps performed successively or simultaneously:a first step of mixing a phenolic substrate selected from the group consisting of a phenol and a phenol ether, with a hydrogen peroxide solution under conditions such that the temperature is sufficient for the starting phenolic substrate selected from the group consisting of a phenol and a phenol ether to remain liquid and for the degree of conversion of the hydrogen peroxide to be minimized,a second step consisting in performing a hydroxylation reaction of the phenolic substrate with hydrogen peroxide under adiabatic conditions to form a hydroxylated product; the acid catalyst being introduced into the mixing step and/or at the start of the hydroxylation reaction, andoptionally, a third step of recovery of the hydroxylated product.2. The process as claimed in ...

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Номер записи: 61
27-03-2014 дата публикации

METHOD OF EXTRACTING PHENOLIC FRACTIONS OF EXTRA VIRGIN OLIVE OIL

Номер: US20140088299A1
Автор: Gutierrez Thomas, Harrell C. Chad, Hillhouse M. Christine, Klapish Timothy A.
Принадлежит: PhytoChem Pharmaceuticals, Inc.

The present invention relates to isolating phenolics from extra virgin olive oil (EVOO) having a low triglyceride and non-polar content. The method includes an ethanol/water extraction with a heptane wash 1. A method for isolating phenolics from EVOO , wherein the isolated phenolics have a low triglyceride and non-polar content comprising:a) selecting a desired quantity of EVOO for extraction;b) extracting the EVOO a plurality of times with an ethanol/water solution;c) isolating the ethanol/water solution after each extraction;d) rinsing the ethanol/water solution with a heptane solution;e) isolate the ethanol/water solution from the heptane; andf) evaporate the ethanol/water solution to remove the phenolics from the solution.2. A method according to wherein the plurality isolated solutions of step c) are combined before step d).3. A method according to wherein the evaporation is carried out by a method selected from the list comprising rotary evaporation and speed vacuum evaporation.4. A method according to wherein the ethanol comprises about 50 to 90 percent of the ethanol/water solution.5. A method according to wherein the ethanol comprises about 80 percent of the ethanol/water solution.6. A method according to which further comprises the addition of further ethanol/water solution to the isolated solution in step e) during the evaporation process.7. A phenolic extract of EVOO manufactured by the method of .8. A polar phenolic extract of EVOO comprising EVOO that has been extracted with an ethanol/water solution than then has been washed with a solution of heptane. This application claims priority of U.S. provisional application No. 61/448,265 filed on Mar. 2, 2011 and included herein in its entirety by reference.A portion of the disclosure of this patent contains material that is subject to copyright protection. The copyright owner has no objection to the reproduction by anyone of the patent document or the patent disclosure as it appears in the Patent and ...

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Номер записи: 62
03-04-2014 дата публикации

Transition-metal free reductive cleavage of aromatic c-o, c-n, and c-s bonds by activated silanes

Номер: US20140091256A1
Автор: Alexey FEDOROV, Anton Toutov, Nicholas A. Swisher, Robert H. Grubbs
Принадлежит: California Institute of Technology CalTech

The present invention describes chemical systems and methods for reducing C—O, C—N, and C—S bonds, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said system optionally comprising at least one molecular hydrogen donor compound, molecular hydrogen, or both.

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Номер записи: 63
10-04-2014 дата публикации

CONTINUOUS PROCESS FOR CONVERSION OF LIGNIN TO USEFUL COMPOUNDS

Номер: US20140096830A1
Автор: Elliott Guliz Arf, Gastaldo Dan, Murray Aaron, Ryba Steven
Принадлежит: CHEMTEX ITALIA, S.P.A.

This specification discloses an operational continuous process to convert lignin as found in ligno-cellulosic biomass before or after converting at least some of the carbohydrates. The continuous process has been demonstrated to create a slurry comprised of lignin, raise the slurry comprised of lignin to ultra-high pressure, deoxygenate the lignin in a lignin conversion reactor over a catalyst which is not a fixed bed without producing char. The conversion products of the carbohydrates or lignin can be further processed into polyester intermediates for use in polyester preforms and bottles. 1. A process for introducing a slurry comprised of lignin into a lignin conversion reactor by pressurizing the slurry comprised of lignin using a pump having an inlet valve which can be present in an inlet valve position selected from the group consisting of open , closed and at least partially open , an outlet valve which can be present in an outlet valve position selected from the group consisting of open , closed and at least partially open , and a pump cavity ,said pressurizing step comprisingA. Passing the slurry comprised of lignin through the inlet valve which is in the inlet valve position selected from the group consisting of at least partially open and open into the pump cavity, with said outlet valve in the closed outlet valve position and the pump cavity being at an inlet pump cavity pressure,B. Changing the inlet valve position to closed,C. Increasing the pressure of the pump cavity to a discharge pressure,D. Discharging at least a portion of the slurry comprised of lignin from the pump cavity into the lignin conversion reactor by changing the outlet valve position to a position selected from the group consisting of at least partially open and open and forcing at least a portion of the slurry comprised of lignin through the outlet valve;wherein the inlet valve and the outlet valve both provide for at least one flow of the slurry comprised of lignin selected from the ...

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Номер записи: 64
10-04-2014 дата публикации

METHOD FOR HYDROXYLATION OF PHENOL

Номер: US20140100392A1
Автор: Hsieh Cheng-Fa, Lin I-Hui, Yao Pin-To
Принадлежит: China Petrochemical Development Corporation, Taipei (Taiwan)

A method for hydroxylation of phenol is disclosed. The method includes the step of performing a reaction of phenol and hydrogen peroxide to form diphenol in the presence of solid catalyst with zeolite framework, wherein the solid catalyst includes silicon oxide, titanium oxide and cobalt oxide. The solid catalyst used in the preparation of diphenol of the present invention has high conversion rate of diphenol, selectivity of diphenol and higher utilization rate of hydrogen peroxide without using high concentration of hydrogen peroxide. 1. A method for hydroxylation of phenol , comprising:performing a reaction of phenol and hydrogen peroxide to form diphenol in the presence of a solvent and a solid catalyst,wherein the solid catalyst has zeolite framework and comprises silicon oxide, titanium oxide and cobalt oxide.2. The method of claim 1 , wherein the solid catalyst has MFI zeolite framework.3. The method of claim 1 , wherein the solid catalyst is obtained from a hydrothermal reaction of titanium source claim 1 , silicon source and cobalt source claim 1 , wherein a molar ratio of titanium from the titanium source to silicon from the silicon source is 0.01 to 0.05 claim 1 , and a molar ratio of cobalt from the cobalt source to the silicon from the silicon source is 0.00001 to 0.002.4. The method of claim 1 , wherein a molar ratio of hydrogen peroxide to phenol is 0.2 to 1.5. The method of claim 1 , wherein an amount of the solid catalyst is 0.5% to 10% of a total weight of phenol and hydrogen peroxide.6. The method of claim 1 , wherein the reaction is performed at a temperature in a range from 20° C. to 100° C.7. The method of claim 1 , wherein the solvent is one or more selected from the group consisting of alcohol claim 1 , ketone claim 1 , nitrile claim 1 , organic acid and water. 1. Field of the InventionThis invention relates to a method for hydroxylation of phenol and, more particularly, to a method for catalyzing the hydroxylation of phenol by using solid ...

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Номер записи: 65
07-01-2016 дата публикации

Process for Making Alkylated Aromatic Compound

Номер: US20160001276A1
Автор: Gabor Kiss, Tan-Jen Chen, Terry E. Helton, Thomas E. Green, William A. Lamberti, William C. Horn
Принадлежит: ExxonMobil Chemical Patents Inc

A process for producing an alkylated aromatic compound comprises contacting an aromatic starting material and hydrogen with a plurality of catalyst particles under hydroalkylation conditions to produce an effluent comprising the alkylated aromatic compound, the catalyst comprising a composite of a solid acid, an inorganic oxide different from the solid acid and a hydrogenation metal, wherein the distribution of the hydrogenation metal in at least 60 wt % of the catalyst particles is such that the average concentration of the hydrogenation metal in the rim portion of a given catalyst particle is Crim, the average concentration of the hydrogenation metal in the center portion of the given catalyst particle is Ccenter, where 0.2≦Crim/Ccenter<2.0. Also disclosed are hydroalkylation catalyst and process for making phenol and/or cyclohexanone using the catalyst.

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Номер записи: 66
02-01-2020 дата публикации

RESINOUS COMPOUND CRYSTALLIZATION USING NON-POLAR SOLVENT SEQUENCE

Номер: US20200001201A1
Автор: Noble Linden
Принадлежит:

A resin containing a desirable compound is extracted from plant material and dissolved in a volatile non-polar solvent. The solvent is evaporated, cooling the solution and increasing the saturation level of the compound in the solution. A second volatile non-polar solvent, in which the compound is less soluble, is then added to the solution and evaporated. This again cools the solution and increases the saturation level until the compound has started to crystallize. The crystals are then filtered and rinsed. Crystallization is more rapid compared to traditional techniques. The resin is obtained from the plant material using an extraction solvent to form a solution, which is then floated above an immiscible liquid, where it is drawn off through a screen and the extraction solvent evaporated. 1. A method for crystallizing a compound from a resin , comprising:mixing a first non-polar solvent with the resin to form a solution;evaporating the first non-polar solvent from the solution;then, mixing a second non-polar solvent with the solution, wherein the compound has a lower solubility in the second non-polar solvent than in the first non-polar solvent;removing the second non-polar solvent from the solution to cause a temperature of the solution to drop and the compound to form crystals.2. The method of claim 1 , wherein the first non-polar solvent has a higher boiling point than the second non-polar solvent.3. The method of claim 1 , wherein the first non-polar solvent is miscible with the second non-polar solvent.4. The method of claim 1 , wherein the first non-polar solvent is butane and the second non-polar solvent is propane.5. The method of claim 1 , wherein the first non-polar solvent is evaporated by pumping off the first non-polar solvent in its gaseous phase.6. The method of claim 1 , wherein the solution is maintained at a temperature of 0-20° C. and between a pressure of 0-140 kPa while evaporating the first non-polar solvent from the solution.7. The method of ...

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Номер записи: 67
07-01-2016 дата публикации

NOVEL PROCESS FOR GENERATING HEMP OIL WITH A HIGH CANNABIDIOL (CBD) CONTENT

Номер: US20160002133A1
Автор: Hartsel Joshua A., III Michael J., Mona, Waterbury Greg
Принадлежит:

A method for producing hemp oil, comprising decarboxylation of CBDA in hemp oil; short-path evaporation of CBD from the decarboxylated hemp oil to produce CBD oil; selective THC to CBN conversion performed on the decarboxylated hemp oil. 1. A method for producing hemp oil , comprising:decarboxylation of CBDA in hemp oil;short-path evaporation of CBD from the decarboxylated hemp oil to produce CBD oil; anda selective THC to CBN conversion performed on the decarboxylated hemp oil.2. The method of claim 1 , wherein decarboxylation of CBDA in hemp oil comprises:starting with virgin CO2 extracted hemp oil that has been extracted from the whole plant;decarboxylating the virgin CO2 extracted hemp oil by heating to 140-150° C. for 10-18 hours to convert the CBDA to CBD.3. The method of claim 5 , wherein upon reaching about 150° C. claim 5 , mixing the resultant solution and then lowering the temperature to about 80° C.4. The method of claim 1 , wherein the short-path evaporation of CBD from the decarboxylated hemp oil to produce CBD oil comprises isolating the CBD from a crude decarboxylated CO2 extract generated by decarboxylation of CBDA in hemp oil using two sequential short-path evaporation steps claim 1 , and wherein the first step comprises:placing decarboxylated hemp oil in a feed tank of a first short-path evaporator;setting the feed tank heater to about 140° C. and allowing the decarboxylated hemp oil to fully melt;maintaining a vacuum of at least 0.5 torr to 0.08 torr with primary vacuum pump.5. The method of claim 7 , wherein the evaporator #1 is set to 250-275° C. with a feed rate of 2-3.5 Hz from a feed tank pump.6. The method of claim 7 , wherein the second step comprises using a second evaporator to refine the CBD to maximum purity.79. The method of claim claim 7 , wherein the second evaporator is set to 160-170° C. and is equipped with an additional diffusion pump capable of achieving an ultimate vacuum of 0.5-0.005 torr. Evaporator #2 is fed at a rate ...

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Номер записи: 68
07-01-2016 дата публикации

Processes for recovering valuable components from a catalytic fast pyrolysis process

Номер: US20160002162A1
Автор: Charles M. Sorensen, Jr., Jeffrey P. WHITING, Marc E. SCHNEIDKRAUT, Michael TANZIO
Принадлежит: Anellotech Inc

Methods of separating products from the catalytic fast pyrolysis of biomass are described. In a preferred method, a portion of the products from a pyrolysis reactor are recovered and separated using a quench system and solvent contacting system that employs materials produced in the pyrolysis process.

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Номер записи: 69
05-01-2017 дата публикации

PROCESS OF PRODUCTION OF 2,5-DIMETHYLPHENOL

Номер: US20170001935A1
Автор: Bonrath Werner, Letinois Ulla, Netscher Thomas
Принадлежит:

The present invention relates to a new method to produce 2,5-dimethylphenol (2,5-DMP). 2. Process according to claim 1 , wherein the catalyst is an Au(I) complex.6. A process according claim 3 , wherein the Au(I) complex is added to reaction mixture as such.7. Process according to claim 3 , wherein the Au(I) complex is formed in situ in the reaction mixture.8. Process according to claim 1 , wherein the substrate to catalyst ratio is 2:1 to 10000:1 claim 1 , preferably are 10:1 to 3000:1 The present invention relates to a new method to produce 2,5-dimethylphenol (2,5-DMP).2,5-dimethylphenol, which is also called 2,5 xylenol, can be used for example as an intermediate in the production of vitamin E.Xylenols are organic compounds with the formula (I)They are volatile colorless solids or oily liquids. They are derivatives of phenol with two methyl groups and a hydroxyl group. Six isomers are existing.Together with many other compounds, xylenols are traditionally extracted from coal tar, the volatile materials obtained in the production of coke from coal. These residues contain a few percent by weight of xylenols as well as cresols and phenol.Together with cresols and cresylic acid, xylenols are an important class of phenolics with great industrial importance. They are used in the manufacture of antioxidants. Xylenol orange is a redox indicator built on a xylenol skeleton. 2,5-DMP, which is the compound of formula (Ia)is an intermediate in the production of the 2,3,6-trimethylphenol (2,3,6-TMP) which is the compound of formula (II)2,3,6-TMP is usually produced by a gasphase methylation of 2,5-DMP.2,3,6-TMP can be used as such (for example in cosmetic formulations) as well as intermediate in the production of other organic compounds, such as for example vitamin E.Due to fact that of 2,5-DMP is obtained from not renewable resources, an alternative, more sustainable production of 2,5-DMP is desirable.We now found a new way for the production of 2,5-DMP, which is carried out ...

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Номер записи: 70
05-01-2017 дата публикации

METHOD OF ALKYLATING OR ACYLATING AN ARENE

Номер: US20170001936A1
Автор: Faust Rudolf
Принадлежит:

A method of alkylating or acylating an arene includes reacting the arene with an organic halide in the presence of an aprotic solvent and a catalyst of formula (I) 1. A method of alkylating or acylating an arene , the method comprising: {'br': None, 'sup': 1', '2', '3, 'sub': m', 'n, 'MRX.Z(R)(R)\u2003\u2003(I)'}, 'reacting an arene with an organic halide selected from the group consisting of unsubstituted or substituted tertiary alkyl halides, unsubstituted or substituted allyl halides, unsubstituted or substituted benzyl halides, and unsubstituted or substituted acyl halides in the presence of a catalyst and an aprotic solvent; wherein the catalyst is of formula (I)'}whereinM is Al, Ga, or Fe;{'sup': '1', 'sub': 1', '12, 'Ris C-Calkyl;'}m is 0 or 1;{'sup': 2', '3, 'sub': 2', '12, 'Rand Rare each independently unsubstituted or substituted C-Calkyl;'}each occurrence of X is independently a halogen;n is 2 or 3;the sum of m and n is 3; andZ is S or O;{'sup': 2', '3, 'provided that when M is Al, then m is 1, n is 2, and Rand Rare each independently substituted with at least one electron-withdrawing group; and'}provided that when M is Ga or Fe, then m is 0 and n is 3.2. The method of claim 1 , wherein the arene is an unsubstituted or substituted C-Carene.3. The method of claim 1 , wherein the arene is an unsubstituted or substituted benzene.4. The method of claim 1 , wherein the arene is a monosubstituted benzene.5. The method of claim 1 , wherein the organic halide is selected from the group consisting of C-Ctertiary alkyl chlorides claim 1 , allyl chloride claim 1 , benzyl chloride claim 1 , and C-Cacyl chlorides.6. The method of claim 1 , wherein the organic halide is t-butyl chloride or acetyl chloride.7. The method of claim 1 , wherein the aprotic solvent is an aliphatic aprotic solvent.8. The method of claim 1 , wherein the aprotic solvent is a C-Calkane.9. The method of claim 1 , wherein M is Al claim 1 , Ris ethyl claim 1 , and each occurrence of X is chloro.10. ...

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Номер записи: 71
04-01-2018 дата публикации

EPOXY COMPOUND, METHOD FOR PRODUCING THE SAME, EPOXY RESIN COMPOSITION, AND CURED PRODUCT THEREOF

Номер: US20180002261A1
Автор: Hayashi Masamichi, Kinoshita Hiroshi, Morinaga Kunihiro, Yoshimoto Yasuyo
Принадлежит:

The present invention provides an epoxy compound which is 2,2′,7,7′-tetraglycidyloxy-1,1′-binaphthalene. Also, the present invention provides a method for producing [1,1′-binaphthalene]-2,2′,7,7′-tetraol, the method including a step of bringing a crude product produced by dimerization reaction of naphthalene-2,7-diol or a naphthalene-2,7-diol derivative into contact with an aromatic solvent; a step of separating [1,1′-binaphthalene]-2,2′,7,7′-tetraol dissolved in the aromatic solvent from insoluble substances; and a step of removing the solvent from a solution of [1,1′-binaphthalene]-2,2′,7,7′-tetraol. The present invention also provides a method for producing an epoxy compound, the method including reacting [1,1′-binaphthalene]-2,2′,7,7′-tetraol or [1,1′-binaphthalene]-2,2′,7,7′-tetraol monohydrate with epihalohydrin. 1. An epoxy compound which is 2 ,2′ ,7 ,7′-tetraglycidyloxy-1 ,1′-binaphthalene.2. A method for producing an epoxy compound , the method comprising reacting [1 ,1′-binaphthalene]-2 ,2′ ,7 ,7′-tetraol or [1 ,1′-binaphthalene]-2 ,2′ ,7 ,7′-tetraol monohydrate with epihalohydrin.3. An epoxy compound produced by the method according to .4. An epoxy resin composition comprising the epoxy compound according to and a curing agent.5. A cured product produced by curing the epoxy resin composition according to .611.-. (canceled)12. An epoxy resin composition comprising the epoxy compound according to and a curing agent.13. A cured product produced by curing the epoxy resin composition according to . This application is a divisional application of U.S. Ser. No. 14/431,968 filed on Mar. 27, 2015, which claims the right of priority under 35 U.S.C. §119 based on Japanese Patent Application Nos. 2012-261035 filed on Nov. 29, 2012 and 2012-216516 filed on Sep. 28, 2012. The entire contents of these applications are incorporated herein by reference in their entirety.The present invention relates to an epoxy compound and a method for producing the compound which ...

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Номер записи: 72
03-01-2019 дата публикации

Method for Preparing Phenolics Using a Catalyst

Номер: US20190002379A1
Автор: CROCKATT Marc, KÖNST Paul Mathijs, Snelders Dennis Johannes Maria, URBANUS Jan HARM
Принадлежит:

The invention is directed to a method for preparing a phenolic compound comprising reacting a furanic compound with a dienophile in the presence of a catalyst comprising yttrium. 1. Method for preparing a phenolic compound comprising reacting a furanic compound with a dienophile in the presence of a catalyst comprising yttrium.2. Method according to claim 1 , wherein the catalyst further comprises a ligand.3. Method according to claim 15 , wherein the electron-withdrawing group is a halogenated group comprising at least one halogen atom claim 15 , a perhalogenated group claim 15 , a perfluoroalkyl claim 15 , or a trifluoromethyl group.4. Method according to claim 1 , wherein the catalyst comprises yttrium(III) triflate.5. Method according to claim 1 , wherein the catalyst is applied on a solid support.9. Method according to claim 1 , wherein reacting the furanic compound with the dienophile is carried out in an apolar claim 1 , aprotic and/or non-coordinating solvent.10. Method according to claim 1 , wherein reacting the furanic compound with the dienophile is carried out at a temperature ranging from −60-350° C.11. Method according to claim 1 , wherein the method comprises reacting the phenolic compound further to obtain a final phenolic product.12. Method according to claim 11 , wherein the phenolic compound is reacted further in one or more reaction steps selected from the group consisting of hydrolysis claim 11 , oxidation claim 11 , reduction claim 11 , nucleophilic addition claim 11 , olefination claim 11 , rearrangement claim 11 , decarboxylation claim 11 , decarbonylation and combinations thereof.13. Method according to claim 11 , wherein the final phenolic product is selected from the group consisting of phenol claim 11 , o-alkylphenol claim 11 , m-alkyphenol claim 11 , p-alkylphenol claim 11 , (e.g. cresols) o-hydroxybenzoic acid claim 11 , m-hydroxybenzoic acid claim 11 , p-hydroxybenzoic acid claim 11 , 2 claim 11 ,6-dialkylphenol claim 11 , 2 claim 11 , ...

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Номер записи: 73
07-01-2021 дата публикации

CHEMICALLY CLEAVABLE GROUP

Номер: US20210002320A1
Автор: Robillard Marc Stefan, ROSSIN RAFFAELLA, Ten Hoeve Wolter, Versteegen Ronny Mathieu
Принадлежит: TAGWORKS PHARMACEUTICALS B.V.

Disclosed is the use of the reactive components of the inverse electron-demand Diels Alder reaction for chemical masking and unmasking in vitro. This can be applied in complex chemical reactions and, particularly in the synthesis of biomolecules, e.g. on solid supports. The reactice components are a dienophile, particularly a trans-cyclooctene, and a diene, particularly a tetrazine. 1. A dienophile as a chemically cleavable group attached to a Construct , thereby provoking the release , in vitro , of the Construct by allowing the dienophile to react with a diene , wherein the dienophile is an eight-membered non-aromatic cyclic alkenylene group , preferably a cyclooctene group , and more preferably a trans-cyclooctene group.11. The dienophile according to claim 10 , wherein the diene satisfies formula (7) as defined in the description. This application is a continuation of U.S. application Ser. No. 14/646,619, filed May 21, 2015, which in turn is a 371 of PCT/NL2013/050850, filed Nov. 22, 2013, which claims the benefit of priority from European Patent Application No. 12193911.0, filed Nov. 22, 2012, the contents of each of which are hereby incorporated by reference.The invention pertains to the field of provoked chemical cleavage. Particularly, the invention pertains to providing chemical substances with a functional group capable of acting as a Trigger for release of an entity attached to said chemical group. This plays a role, e.g., in solid phase synthesis, biomolecule interactions, modification of surfaces (including cell surfaces), and modification of molecules under physiological conditions (e.g., in a cellular environment).The current state of the art in organic chemistry enables the preparation of highly complex molecular structures, by application of a wide toolbox of synthetic transformations. Unfortunately, the vast majority of chemical techniques is executed under strictly defined conditions, requiring toxic solvents, stoichiometric reagents, extreme ...

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Номер записи: 74
13-01-2022 дата публикации

Method for decomposing phenolic by-product

Номер: US20220009868A1
Автор: Joon Ho Shin, Min Suk Kang, Sang Beom Lee
Принадлежит: LG Chem Ltd

The present disclosure provides a method for decomposing a phenolic by-product, the method including: a step S10 of injecting and mixing a bisphenol A by-product produced in a bisphenol A production process, a mixed by-product stream of phenol by-products produced in a phenol production process, a decomposition apparatus side discharge stream, and a process water stream in a mixing apparatus; a step S20 of injecting a mixing apparatus discharge stream discharged from the mixing apparatus into a phase separation apparatus and phase-separating the mixing apparatus discharge stream into an oil-phase stream and a liquid-phase stream; a step S30 of feeding the oil-phase stream, which is phase-separated in the step S20 and discharged from the phase separation apparatus, to a decomposition apparatus to decompose the oil-phase stream; and a step S40 of circulating the decomposition apparatus side discharge stream obtained by the decomposition in the step S30 to the mixing apparatus in the step S10.

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Номер записи: 75
01-01-2015 дата публикации

Hydroalkylation Process

Номер: US20150005531A1
Автор: Becker Christopher L., Kuechler Keith H., Lattner James R., Nair Hari
Принадлежит: ExxonMobil Chemical Patents Inc.

In a process for producing phenol, benzene is hydroalkylated with hydrogen in the presence of a catalyst under conditions effective to produce a hydroalkylation reaction product comprising cyclohexylbenzene and cyclohexane. At least a portion of the cyclohexane from said hydroalkylation reaction product is then dehydrogenated to produce a dehydrogenation effluent comprising benzene, toluene and hydrogen. At least a portion of the dehydrogenation effluent is washed with a benzene-containing stream to transfer at least a portion of the toluene from the dehydrogenation effluent to the benzene-containing stream. 1. A hydroalkylation process comprising:(a) hydroalkylating benzene with hydrogen in the presence of a catalyst under conditions effective to produce a hydroalkylation reaction product comprising cyclohexylbenzene and cyclohexane;(b) contacting at least a portion of the hydroalkylation reaction product with a dehydrogenation catalyst to produce a dehydrogenation effluent having at least a portion of the cyclohexane converted to benzene and hydrogen, wherein the dehydrogenation effluent further comprises toluene; and(c) washing at least a portion of the dehydrogenation effluent with a benzene-containing stream to produce a toluene-depleted dehydrogenation effluent and a wash stream containing at least a portion of the toluene from the dehydrogenation effluent, wherein the at least a portion of the dehydrogenation effluent is in the vapor phase and the benzene-containing stream is in the liquid phase.2. The process of claim 1 , wherein the at least a portion of the dehydrogenation effluent contains at least 50 wt % hydrogen claim 1 , the wt % based upon the weight of the at least a portion of the dehydrogenation effluent.3. The process of claim 1 , wherein at least a portion of the toluene in the dehydrogenation effluent is formed from the decomposition of the cyclohexylbenzene.4. The process of claim 1 , wherein the wash stream contains at least 80 wt % of the ...

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Номер записи: 76
01-01-2015 дата публикации

Postharvest production and enhancement of resveratrol and piceatannol in sugarcane

Номер: US20150005533A1
Автор: Bhatnagar Deepak, BOUE Stephen M., BUROW Matthew E.
Принадлежит: THE ADMINISTRATORS OF THE TULANE EDCATIONAL FUND

It has been discovered that irradiating the cut side of sugarcane billets, preferably 2-50 mm, with UVB or UVC light or combinations thereof initiates stilbene production, particularly resveratrol and piceatannol. In an embodiment the cut sides of sugarcane billets of a predetermined thickness are irradiated with Ultraviolet-C or Ultraviolet-B light or combinations thereof at an intensity and for a duration of time sufficient to produce a significant increase in a level of one or more stilbenes in the irradiated billets compared to a level of stilbenes in billets that are not irradiated; and the the irradiated sugarcane billets are maintained for at least about three days up to about 20 days, to optimize stilbene levels. 1. A method , comprisinga) providing sugarcane billets of a predetermined thickness;b) irradiating the cut side of sugarcane billets with Ultraviolet-C or Ultraviolet-B light or combinations thereof at an intensity and for a duration of time sufficient to produce a significant increase in a level of one or more stilbenes in the irradiated billets compared to a level of stilbenes in billets that are not irradiated;c) maintaining the irradiated sugarcane billets for at least about three days up to about 20 days; andd) selecting the irradiated sugarcane billets.2. The method of claim 1 , wherein the irradiated sugarcane billets are maintained in step (c) at a level of light that does not cause stilbene isomerization.3. The method of claim 1 , wherein the sugarcane billets range from about 2 mm to about 50 mm in thickness.4. The method of claim 1 , wherein the intensity of UVB light ranges from about 10 mW/cm2 to about 50 W/cm2.5. The method of claim 1 , wherein the intensity of UVC light ranges from about 1 mW/cm2 to about 25 mW/cm2.6. The method of claim 1 , wherein the duration of irradiation ranges from about 10 minutes to about 3 hours.7. The method of claim 1 , wherein the stilbene is resveratrol.8. The method of claim 1 , wherein the stilbene is ...

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Номер записи: 77
14-01-2016 дата публикации

PROCESS FOR PURIFYING HYDROCARBONS

Номер: US20160008735A1
Автор: Lindholm Tero, Pakala Tero, Pakala Timo, Saukonoja Jouni
Принадлежит:

A process for washing hydrocarbons said process comprising: (I) distilling a crude acetone mixture preferably obtained from the cleavage of cumene hydroperoxide and containing hydrocarbons and water so as to form a bottoms fraction containing said hydrocarbons in an organic phase and an aqueous phase; (II) contacting at least a part of said bottoms fraction with an aqueous metal hydroxide solution so as to provide a concentration of 0.1 to 5 wt % MOH, where M is an alkali metal, in the aqueous phase; (III) separating the aqueous phase and the organic phase; (IV) contacting at least a part the organic phase from step (III) with an aqueous metal hydroxide solution so as to provide a concentration of 6 to 20 wt % MOH in the aqueous phase; (V) separating the organic phase and aqueous phase formed in step (IV); (VI) washing at least a part of the organic phase of step (V) with water. 1. A process comprising:(I) distilling a crude acetone mixture containing hydrocarbons and water so as to form a bottoms fraction containing said hydrocarbons in an organic phase and an aqueous phase;(II) contacting at least a part of said bottoms fraction with an aqueous metal hydroxide solution so as to provide a concentration of 0.1 to 5 wt % MOH, where M is an alkali metal, in the aqueous phase;(III) separating the aqueous phase and the organic phase;(IV) contacting at least a part the organic phase from step (III) with an aqueous metal hydroxide solution so as to provide a concentration of 6 to 20 wt % MOH, where M is an alkali metal, in the aqueous phase;(V) separating the organic phase and aqueous phase formed in step (IV);(VI) washing at least a part of the organic phase of step (V) with water.2. A process as claimed in wherein the hydrocarbons comprise cumene and alpha methyl styrene (AMS).3. A process as claimed in said process comprising:(I) distilling a crude acetone mixture obtained from the cleavage of cumene hydroperoxide and containing hydrocarbons and water so as to form a ...

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Номер записи: 78
12-01-2017 дата публикации

Process for producing 2,5-dihalophenolethers

Номер: US20170008824A1
Автор: David Cortes, Eric George Klauber, Gerald SCHMELEBECK, Junmin JI, Michael Rack, Nicole HOLUB, Thomas Zierke
Принадлежит: BASF SE

The present invention relates to a process for providing a compound of formula (IV): wherein R 1 and R 2 are each independently C 1 -C 4 alkyl, and Hal is independently Cl or Br, the process comprising the steps of: (i) reacting a compound of formula (II) wherein R 1 and Hal is defined as above, to obtain a compound of formula (III) wherein R 1 and Hal is defined as above, and (ii) reacting the compound of formula (III) to obtain the compound of formula (IV).

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Номер записи: 79
12-01-2017 дата публикации

ELECTROCHEMICALLY ACTIVE AGENTS FOR PH MODULATION IN BIOLOGICAL BUFFERS

Номер: US20170008825A1
Автор: Ahmad Habib, Fomina Nadezda, Johnson Christopher, Kavusi Sam, Lang Christoph, Maruniak Autumn, RAGHUNATHAN Ashwin
Принадлежит:

Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample. 1. An electrochemically active composition comprising a quinone derivative , wherein:a reactivity between a nucleophile and the quinone derivative is reduced compared to a reactivity between the nucleophile and an unsubstituted quinone from which the quinone derivative is derived, andthe composition is configured such that the pH of the composition is electrochemically modulated via the quinone derivative.3. The composition of claim 2 , wherein all of the R groups of the quinone derivative are different from each other.4. The composition of claim 2 , wherein two or more of the R groups of the quinone derivative are the same.5. The composition of claim 1 , wherein the composition is an aqueous solution.6. The composition of claim 1 , further comprising an additive selected from the group consisting of: an aqueous buffer claim 1 , an organic solvent claim 1 , an electrolyte claim 1 , a buffer salt claim 1 , a bioreagent claim 1 , a biomolecule claim 1 , a surfactant claim 1 , a preservative claim 1 , a cryoprotectant claim 1 , and combinations thereof.7. The composition of claim 1 , wherein the one or more nucleophiles are selected from the group ...

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Номер записи: 80
12-01-2017 дата публикации

PROCESS FOR THE PRODUCTION OF CANNABIDIOL AND DELTA-9-TETRAHYDROCANNABINOL

Номер: US20170008869A1
Автор: Dialer Lukas, Petrovic Denis, WEIGL ULRICH
Принадлежит:

The present disclosure relates to the preparation of a cannabidiol compound or a derivative thereof. The cannabidiol compound or derivatives thereof can be prepared by an acid-catalyzed reaction of a suitably selected and substituted di-halo-olivetol or derivative thereof with a suitably selected and substituted cyclic alkene to produce a dihalo-cannabidiol compound or derivative thereof. The dihalo-cannabidiol compound or derivative thereof can be produced in high yield, high stereospecificity, or both. It can then be converted under reducing conditions to a cannabidiol compound or derivatives thereof. 6. The process of wherein the compound of formula (I) is selected from the group consisting of ethyl cannabidiolate claim 1 , delta-9-tetrahydrocannabidiol and delta-8-tetrahydrocannabidiol.7. The process of wherein the protic or first Lewis acid catalyst is selected from the group consisting of p-toluene sulfonic acid claim 1 , trifluoromethanesulfonic acid claim 1 , trifluoroacetic acid claim 1 , acetic acid claim 1 , sulfuric acid claim 1 , iron(II) chloride claim 1 , scandium(III) triflate claim 1 , zinc chloride claim 1 , aluminum chloride and combinations thereof.8. The process of wherein the second Lewis acid catalyst is selected from the group consisting of p-toluene sulfonic acid claim 1 , BF claim 1 , diethyl etherate claim 1 , BF*AcOH claim 1 , tri-isobutyl aluminum claim 1 , and combinations thereof.9. The process of wherein the reducing agent is a sulfur-containing compound.10. The process of wherein the reduction occurs in a polar solvent.11. The process of wherein the reduction occurs in the presence of an organic or weak inorganic base.16. The process of wherein the protic or first Lewis acid catalyst is selected from the group consisting of p-toluene sulfonic acid claim 12 , trifluoromethanesulfonic acid claim 12 , trifluoroacetic acid claim 12 , acetic acid claim 12 , sulfuric acid claim 12 , iron(II) chloride claim 12 , scandium(III) triflate claim ...

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Номер записи: 81
14-01-2016 дата публикации

Process for Making Alkylated Aromatic Compound

Номер: US20160009613A1
Автор: Chen Tan-Jen, Green Thomas E., Helton Terry E., Horn William C., Kiss Gabor, Lamberti William A.
Принадлежит:

A process for producing an alkylated aromatic compound comprises contacting an aromatic starting material and hydrogen with a plurality of catalyst particles under hydroalkylation conditions to produce an effluent comprising the alkylated aromatic compound, the catalyst comprising a composite of a solid acid, an inorganic oxide different from the solid acid and a hydrogenation metal, wherein the distribution of the hydrogenation metal in at least 60 wt % of the catalyst particles is such that the average concentration of the hydrogenation metal in the rim portion of a given catalyst particle is Crim, the average concentration of the hydrogenation metal in the outer portion of a given catalyst particle is Couter, the average concentration of the hydrogenation metal in the center portion of the given catalyst particle is Ccenter, where Crim/Ccenter≧2.0 and/or Couter/Ccenter2.0. Also disclosed are rimmed catalyst and process for making phenol and/or cyclohexanone using the catalyst. 1. A process for producing an alkylated aromatic compound , the process comprising contacting an aromatic starting material and hydrogen with a plurality of catalyst particles under hydroalkylation conditions to produce an effluent comprising the alkylated aromatic compound , the catalyst comprising a composite of a solid acid , an inorganic oxide different from the solid acid and a hydrogenation metal , wherein the distribution of the hydrogenation metal in at least 60 wt % of the catalyst particles is such that:the average concentration of the hydrogenation metal in the rim portion of a given catalyst particle is Crim;the average concentration of the hydrogenation metal in the outer portion of a given catalyst particle is Couter; andthe average concentration of the hydrogenation metal in the center portion of the given catalyst particle is Ccenter; andat least one of the following conditions is met:(i) Crim/Ccenter≧2.0; and(ii) Couter/Ccenter≧2.0.2. The process of claim 1 , wherein the ...

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Номер записи: 82
14-01-2016 дата публикации

PHENOLIC EPOXY COMPOUNDS

Номер: US20160009672A1
Автор: Adam Georgius Abidal
Принадлежит:

Disclosed herein are compositions and methods of making phenolic compounds, and resins comprising these phenolic compounds. The compounds include multifunctional epoxies, amino glycidyl derivatives, and multi-functional amines prepared from hydroxymethyl derivatives of phenols and bisphenols. 25-. (canceled)6. The compound of claim 1 , wherein:{'sub': '1', 'Ris H or Z;'}{'sub': 2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris —N(Z), —N(CH—O—Z), —N(CHCH—O—Z), —N(CHOH), —N(CHNH), or —N(CHCHOH);'}{'sub': 3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris —N(Z), —N(CH—O—Z), —N(CHCH—O—Z), —N(CHOH), —N(CHNH), or —N(CHCHOH); and'}{'sub': 4', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris —N(Z), —N(CH—O—Z), —N(CHCH—O—Z), —N(CHOH), —N(CHNH), or —N(CHCHOH).'}7. The compound of claim 1 , wherein:{'sub': '1', 'Ris Z;'}{'sub': 2', '2', '2', '2', '2', '2', '2, 'Ris —N(Z), —N(CH—O—Z), or —N(CHCH—O—Z);'}{'sub': 3', '2', '2', '2', '2', '2', '2, 'Ris —N(Z), —N(CH—O—Z), or —N(CHCH—O—Z); and'}{'sub': 4', '2', '2', '2', '2', '2', '2, 'Ris —N(Z), —N(CH—O—Z), or —N(CHCH—O—Z).'}8. The compound of claim 1 , wherein Ris Z claim 1 , Ris —N(Z) claim 1 , Ris —N(Z)and Ris —N(Z).9. The compound of claim 1 , wherein Ris Z claim 1 , and each of Ris —N(CH—O—Z) claim 1 , Ris{'sub': 2', '2', '4', '2', '2, '—N(CH—O—Z)and Ris —N(CH—O—Z).'}10. The compound of claim 1 , wherein Ris Z claim 1 , and each of Ris —N(CHCH—O—Z) claim 1 , Ris{'sub': 2', '2', '2', '4', '2', '2', '2, '—N(CHCH—O—Z)and Ris —N(CHCH—O—Z).'}11. The compound of claim 1 , wherein:{'sub': '1', 'Ris H;'}{'sub': 2', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris —N(CHOH), —N(CHNH), or —N(CHCHOH);'}{'sub': 3', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris —N(CHOH), —N(CHNH), or —N(CHCHOH); and'}{'sub': 4', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris —N(CHOH), —N(CHNH), or —N(CHCHOH).'}12. The compound of claim 1 , wherein Ris H claim 1 , Ris —N(CHOH) claim 1 , Ris ...

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Номер записи: 83
27-01-2022 дата публикации

METHODS OF SYNTHESIZING CANNABIGERGOL, CANNABIGEROLIC ACID, AND ANALOGS THEREOF

Номер: US20220024843A1
Автор: BRUMAR Daniel, FARD Mahmood Azizpour, Geiling Ben, HAGHDOOST MANJILI Mohammadmehdi
Принадлежит: CANOPY GROWTH CORPORATION

Disclosed are methods for preparing cannabigerol (CBG) or a CBG analog, embodiments of the method comprising providing a compound (I); combining the compound (I) with geraniol and a solvent to form a reaction mixture; and combining the reaction mixture with an acid catalyst to form a product mixture comprising the CBG or the CBG homolog. The method may further comprise separating the CBG or the CBG analog from the product mixture and may further comprise purifying the CBG or CBG analog. Methods for preparing cannabigerolic acid (CBGA) or a cannabigerolic acid analog are also disclosed. The present disclosure also provides highly purity CBG, CBGA, and analogs thereof. 2. The method of claim 1 , wherein the acid catalyst is camphorsulfonic acid.3. The method of claim 1 , wherein the acid catalyst is acidic alumina.4. The method of claim 1 , wherein the acid catalyst is montmorillonite K10.5. The method of claim 1 , wherein the acid catalyst is iron (III) perchlorate hydrate.6. The method of claim 1 , wherein the method includes the solvent.7. The method of claim 6 , wherein the solvent is chloroform claim 6 , heptane claim 6 , tert-butylmethyl ether claim 6 , diethyl ether claim 6 , dichloromethane claim 6 , dichloroethane claim 6 , trifluorotoluene claim 6 , hexane claim 6 , cyclohexane claim 6 , pentane claim 6 , toluene claim 6 , or any combination thereof.8. The method of claim 1 , wherein the compound (I) and geraniol are present in a compound (I):geraniol molar ratio of between about 1:1.5 and about 1:3.5.9. The method of claim 8 , wherein the compound (I):geraniol molar ratio is between about 1:1.5 to about 1:2.10. The method of claim 9 , wherein the compound (I):geraniol molar ratio is about 1:1.7.11. The method of claim 1 , wherein the acid catalyst is in an amount of between about 0.001 and about 0.5 molar equivalents with respect to the compound (I).12. The method of claim 1 , wherein Ris C-Calkyl.13. The method of claim 1 , wherein Ris CH.14. The method of ...

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Номер записи: 84
14-01-2021 дата публикации

Menaquinol Compositions and Methods of Treatment

Номер: US20210009494A1
Автор: Drouet Keith E., Rudey John M., Tumlin James A.
Принадлежит: Epizon Pharma, Inc.

The present application discloses methods for the efficient preparation of high purity compounds of the Formula I, and their methods of use. 146.-. (canceled)48. The method of claim 47 , wherein the method comprises administering the menaquinol compound of the Formula I claim 47 , wherein:m is 7, 8, 9 or 10;{'sup': 1', '2, 'Rand Rare both the residue 15;'}{'sup': 1', '2, 'Rand Rare both the residue 16;'}{'sup': 1', '2, 'Rand Rare both the residue 17;'}{'sup': 1', '2, 'Rand Rare both the residue 18;'}{'sup': 1', '2, 'Rand Rare both the residue 20;'}{'sup': 1', '2, 'Rand Rare both the residue 21;'}{'sup': 1', '2, 'Rand Rare both the residue 22;'}{'sup': 1', '2, 'Rand Rare both the residue 23;'}{'sup': 1', '2, 'Rand Rare both the residue 24;'}{'sup': 1', '2, 'Rand Rare both the residue 25;'}{'sup': 1', '2, 'Rand Rare both the residue 26;'}{'sup': 1', '2, 'Rand Rare both the residue 27; and'}{'sup': 1', '2, 'Rand Rare both the residue 28.'}54. The method of claim 47 , wherein the mammal has distal calciphylaxis and/or central calciphylaxis.55. The method of claim 47 , wherein the mammal has diabetes claim 47 , chronic kidney disease or end stage renal disease.57. The method of claim 56 , wherein the method comprises administering the menaquinol compound of the Formula I claim 56 , wherein:m is 7, 8, 9 or 10;{'sup': 1', '2, 'Rand Rare both the residue 15;'}{'sup': 1', '2, 'Rand Rare both the residue 16;'}{'sup': 1', '2, 'Rand Rare both the residue 17;'}{'sup': 1', '2, 'Rand Rare both the residue 18;'}{'sup': 1', '2, 'Rand Rare both the residue 20;'}{'sup': 1', '2, 'Rand Rare both the residue 21;'}{'sup': 1', '2, 'Rand Rare both the residue 22;'}{'sup': 1', '2, 'Rand Rare both the residue 23;'}{'sup': 1', '2, 'Rand Rare both the residue 24;'}{'sup': 1', '2, 'Rand Rare both the residue 25;'}{'sup': 1', '2, 'Rand Rare both the residue 26;'}{'sup': 1', '2, 'Rand Rare both the residue 27; and'}{'sup': 1', '2, 'Rand Rare both the residue 28.'}63. The method of claim 56 , ...

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Номер записи: 85
14-01-2021 дата публикации

BURST ATOMIZATION FRACTIONATION SYSTEM, METHOD AND APPARATUS

Номер: US20210009548A1
Автор: Casserly Thomas B., MCEUEN MARION, Papa Frank, Vogler Jeffrey F.
Принадлежит: FOG ATOMIC TECHNOLOGIES LLC

Systems, methods and apparatus for fractioning mixtures comprising combinations of volatiles, essentially non-volatiles and non-volatile solutes are disclosed. Embodiments of a burst atomization fractionation apparatus comprises an atomization chamber into which a liquid mixture is atomized across a pressure gradient. In various embodiments, a mixture for fractionation comprises mixtures of solvents, solvents and oils, used engine oil, or salt water. In various examples, a solute undergoes a chemical transformation during the fractionation process, such as dehydrogenation, dehydration, or decarboxylation. 1. A burst atomization fractionation apparatus comprising:an atomization chamber having interior walls defining an interior, the atomization chamber fitted with an atomizer fluidically connecting a liquid feed inlet to the interior of the atomization chamber, the atomizer configured to atomize a liquid mixture from the liquid feed inlet into the interior of the atomization chamber in the form of atomized fine particles;a vacuum pump fluidically connecting the interior of the atomization chamber through a vapor outlet to an environment outside the atomization chamber; anda liquid outlet fluidically connecting the interior of the atomization chamber to an environment outside the atomization chamber.2. The burst atomization fractionation apparatus of claim 1 , wherein the atomizer comprises an atomization nozzle or an ultrasonic nebulizer.3. The burst atomization fractionation apparatus of claim 1 , further comprising a liquid feed tank fluidically connected to the liquid feed inlet claim 1 , the liquid feed tank configured to feed a liquid mixture contained in the liquid feed tank to the liquid feed inlet.4. The burst atomization fractionation apparatus of claim 3 , further comprising a pressurized tank of process gas fluidically connected to at least one of the liquid feed tank or the liquid feed inlet claim 3 , the pressurized tank of process gas configured to ...

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Номер записи: 86
08-01-2015 дата публикации

PROCESS OF PRODUCING AND USE OF A TREATED, PROMOTED ION EXCHANGE RESIN CATALYST

Номер: US20150011800A1
Автор: Olsen Robert James, Pierce Gregory C., Schultz Alfred K., Topp Klaus-Dieter
Принадлежит: Rohm and Haas Company

The present invention relates to the treatment of a promoted strong acid ion exchange resin for use as an acid catalyst with an antioxidant to protect the resin from oxidative degradation and the use of said treated promoted ion exchange resin catalyst in chemical production processes. 1. A process for producing a treated promoted ion exchange resin catalyst comprising contacting the promoted ion exchange resin catalyst with an antioxidant to produce a treated promoted ion exchange resin.2. The process of wherein the ion exchange resin catalyst is a sulfonic acid-type cation-exchange resin catalyst.3. The process of wherein the cation-exchange resin catalyst is a sulfonated styrene-divinyl benzene copolymer.4. The process of wherein the antioxidant is a monocyclic or polycyclic phenol claim 1 , an amine claim 1 , a diamine claim 1 , a thioester claim 1 , a phosphate claim 1 , a quinoline claim 1 , or a mixture thereof.5. The process of wherein the antioxidant is 2 claim 1 ,6-di-t-butyl-.alpha.-dimethylamino-p-cresol.6. The process of wherein the amount of antioxidant incorporated into the cation-exchange resin catalyst is from 0.001 to 10 percent by weight.7. The treated promoted ion exchange resin of .8. The method of using the treated promoted ion exchange resin of in a condensation reaction. The present invention relates to the treatment of a promoted strong acid ion exchange resin for use as an acid catalyst with an antioxidant to protect the resin from oxidative degradation and the use of said treated promoted ion exchange resin catalyst in chemical production processes.Polymeric promoted ion exchange resins, such as sulfonated styrene-divinylbenzene types of strong acid ion exchange resins are used as catalysts in the production of various organic chemicals including for example bisphenol-A and alkyl phenol. These catalysts are susceptible to oxidation during manufacture, storage, handling, processing, washing, and drying prior to use. Oxidative degradation ...

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Номер записи: 87
08-01-2015 дата публикации

Catalytic Pulsed Flow Hydrogenation Of Lignin Carboxylic Acid Compounds

Номер: US20150011801A1
Автор: Carter M. K.
Принадлежит: Carter Technologies Corporation

Renewable resources comprising bagasse, corn stover, wood sawdust and switch grass are subject to direct catalytic conversion or bio-fermentation producing ethanol leaving complex lignin compounds for disposal. Chemical conversion of lignin compounds (recoverable from digested lignin) to substituted phenols followed by a carbon steel catalyzed pulsed flow hydrogenation produces cresol and substituted creosol compounds. The pulsed flow process produced close to 100 percent reduction of the reactants compared to 25 percent with continuous flow and is applicable to aliphatic carboxylic acid compounds such as natural oils producing valued liquid hydrocarbons. 1. A catalytic , pulsed flow hydrogenation process for substituted carboxylic acid compounds in contact with a carbon steel catalytic surface , a promoter comprising an anhydrous sodium sulfate with no mineral acid or alkaline material and an activator comprising Co(II)-Co(III)-Co(II) made from tri-metal compounds of mixed valence produced from cobalt using hydrogen gas at 225° C. to 350° C. and ambient to 10 atmospheres pressure forming substituted methyl compounds.2. A catalytic , pulsed flow hydrogenation process for substituted lignin acids (recoverable from digested lignin) comprising 4-hydroxy-3 ,5-dimethoxybenzoic acid , 4 ,5-dihydroxy-3-methoxybenzoic acid , 4-hydroxy-3-methoxybenzoic acid or 4-hydroxybenzoic acid compounds in contact with a carbon steel catalytic surface , a promoter comprising an anhydrous sodium sulfate with no mineral acid or alkaline material and an activator comprising Co(II)-Co(III)-Co(II) made from tri-metal compounds of mixed valence produced from cobalt using hydrogen gas at 225° C. to 350° C. and ambient to 10 atmospheres pressure forming substituted methyl carboxylic acid compounds comprising cresols or substituted cresols.3. A catalytic , pulsed flow hydrogenation process for substituted aliphatic carboxylic acid compounds comprising citric acid or oleic acid in contact with a ...

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Номер записи: 88
10-01-2019 дата публикации

PROCESS FOR PURIFICATION AND SEPARATION OF CANNABINOIDS, FROM DRIED HEMP AND CANNABIS LEAVES

Номер: US20190010106A1
Автор: ADEL Faridedin, Chen Xinjie, Edirisinghe Praneeth Dayanthe, House David W., OROSKAR Anil Rajaram, OROSKAR Asha Anil, OROSKAR Gautham Anil
Принадлежит:

Disclosed is a method for purification and separation of cannabinoids, specifically cannabidiol and tetrahydrocannabinol, from the dried hemp and leaves using a combination of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, a continuous simulated moving bed process, polishing, and crystallization to separate cannabinoids from tetrahydrocannabinol and to provide phytocannabinoid rich oil and cannabidiol isolate. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications. 1cannabis. A process for the purification of cannabidiol (CBD) in a crude extract stream to provide at least one high purity cannabidiol product selected from the group consisting of a high purity cannabinoid oil stream , a phytocannabinoid rich oil , a solid CBD aggregate and mixtures thereof being essentially free of tetrahydrocannabinol , said process comprising:{'i': 'cannabis', 'a) passing the crude extract stream comprising debris and small particles, cannabidiol, tetrahydrocannabinol, cannabidiolic acid, tetrahydrocannabinolic acid, other cannabinols, chlorophylls, color bodies, sugars and carbohydrates, lipids, plant waxes, impurities, and ethanol to a first filtration zone comprising a series of successive filters of decreasing pore size, starting at a pore size of 100 microns and reducing to about 10 microns in 3 or more stages to remove debris and small particles in a progressive filtration step to provide a filtered crude cannabinoid stream;'}b) passing the filtered crude cannabinoid stream comprising cannabidiol, tetrahydrocannabinol, cannabidiolic acid, tetrahydrocannabinolic acid, other cannabinols, chlorophylls, color bodies, sugars and carbohydrates, lipids, plant waxes, impurities, and ethanol to a decolorization zone comprising a 10 μm filter and a decolorization chromatographic column containing a modified activated carbon adsorbent which was heat treated to provide a highly ...

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Номер записи: 89
10-01-2019 дата публикации

PROCESS FOR PURIFICATION AND SEPARATION OF CANNABINOIDS, FROM DRIED HEMP AND CANNABIS LEAVES

Номер: US20190010107A1
Автор: ADEL Faridedin, Chen Xinjie, Edirisinghe Praneeth Dayanthe, House David W., OROSKAR Anil Rajaram, OROSKAR Asha Anil, OROSKAR Gautham Anil
Принадлежит: OROCHEM TECHNOLOGIES, INC.

A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from the dried hemp and leaves can use a continuous simulated moving bed process and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications. 1cannabiscannabis. A method of separating a cannabinoid from a plant , the plant including the cannabinoid and at least one impurity , the method comprising:{'i': cannabis', 'cannabis, 'combining the plant and a solvent to form a crude extract stream;'}{'i': cannabis', 'cannabis, 'processing the crude extract stream into a simulated moving bed (SMB) feedstock stream by removing at least a portion of at least one impurity in the crude extract stream; and'}passing the SMB feedstock stream through a SMB zone to provide a primary raffinate stream having a higher purity of the cannabinoid than in the SMB feedstock stream as measured by weight percentage of the solid content and a SMB extract stream having a lower purity of the cannabinoid than in the SMB feedstock stream as measured by weight percentage of the solid content.2cannabisCannabis sativa, Cannabis indica, Cannabis rudralis. The method of claim 1 , wherein the plant is selected from claim 1 , and mixtures thereof.3cannabiscannabis. The method of claim 1 , wherein the plant comprises dried hemp claim 1 , leaves claim 1 , or a mixture thereof.4. The method of claim 1 , wherein the solvent comprises ethanol.5cannabiscannabiscannabiscannabiscannabiscannabiscannabiscannabiscannabis. The method of claim 1 , wherein said at least one impurity comprises at least one of color bodies claim 1 , acidic components claim 1 , lipids claim 1 , and plant waxes claim 1 , and wherein ...

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Номер записи: 90
10-01-2019 дата публикации

PROCESS FOR SEPARATING A CONSTITUENT/CANNABINOID USING A CHROMATOGRAPHIC RESIN

Номер: US20190010110A1
Автор: ADEL Faridedin, Chen Xinjie, Edirisinghe Praneeth Dayanthe, House David W., OROSKAR Anil Rajaram, OROSKAR Asha Anil, OROSKAR Gautham Anil
Принадлежит: OROCHEM TECHNOLOGIES, INC.

A method for purification and separation of cannabinoids, such as cannabidiol and tetrahydrocannabinol, e.g., from dried hemp and leaves can use a continuous simulated moving bed process, a batch column chromatography method, or a single column, and a combination of one or more of a sequence of purification steps including: filtration, decolorization, activation or decarboxylation, dewaxing, polishing, and crystallization to separate a cannabinoid from the plant and to provide various cannabinoid products. The cannabinoid products can be used in various pharmaceutical and nutraceutical applications. 1cannabiscannabis. A method of separating a cannabinoid of a plant , the plant including the cannabinoid and at least one impurity , the method comprising:{'i': 'cannabis', 'preparing a feedstock stream, the feedstock stream including the plant and a solvent;'} a first resin, the first resin comprising a modified activated carbon adsorbent having an average particle size range of from about 45 to about 1700 microns,', 'a second resin, the second resin comprising a modified hydrophobic adsorbent having an average bulk density of from about 0.4 g/mL to about 0.6 g/mL, the modified hydrophobic adsorbent comprising at least one of a styrene-divinylbenzene (DVB) resin or a poly(methyl methacrylate) (PMMA) resin,', 'a third resin, the third resin comprising a hydrophobic resin having an average bulk density of from about 0.75 g/mL to about 0.85 g/mL,', 'a fourth resin, the fourth resin comprising a hydrophobic polystyrene-divinylbenzene adsorbent having a water content of from about 55% to about 65%, and', 'any mixture thereof., 'passing the feedstock stream through a chromatographic resin to provide an eluate stream, the eluate stream having a higher purity of the cannabinoid than in the feedstock stream as measured by weight percentage of the solid content, wherein the chromatographic resin comprises at least one of2. The method of claim 1 , wherein the cannabinoid is CBD ...

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Номер записи: 91
10-01-2019 дата публикации

Preparation of Phenyl Compounds

Номер: US20190010111A1
Автор: CROCKATT Marc, KÖNST Paul Mathijs, URBANUS Jan HARM
Принадлежит:

The invention relates to a method for preparing a compound comprising two phenyl groups by reacting a bisfuranic compound with a dienophile; and to such compounds. 1. Method for preparing a compound comprising two phenyl groups by reacting a bisfuranic compound with a dienophile.5. The method according to claim 4 , wherein R4 is hydrogen.7. The method according to claim 4 , wherein an alkyne dienophile is used and wherein the product is a bisphenol claim 4 , preferably bisphenol A claim 4 , AP claim 4 , AF claim 4 , B claim 4 , BP claim 4 , C1 claim 4 , C2 claim 4 , E claim 4 , F claim 4 , TMZ or Z claim 4 , more preferably bisphenol A claim 4 , B claim 4 , C1 claim 4 , E claim 4 , F or Z.8. The method according to according to claim 4 , wherein the dienophile is an alkene with formula (IIIa) claim 4 , wherein R4 is H and R5 is —SO3X claim 4 , wherein X is H or linear or branched C1-C8-alkyl claim 4 , optionally substituted with halogens.9. The method according to claim 1 , wherein the reaction is catalysed with a Lewis acid.10. The method according to claim 1 , comprising further reacting the compound comprising two phenyl groups in one or more reactions selected from the group consisting of hydrolysis claim 1 , reduction claim 1 , oxidation claim 1 , decarboxylation claim 1 , decarbonylation claim 1 , nucleophilic addition claim 1 , olefination claim 1 , rearrangement and combinations thereof.11. The method according to claim 1 , further comprising removing substituents from the formed phenyl groups.14. The method according to claim 7 , wherein the product is bisphenol A claim 7 , AP claim 7 , AF claim 7 , B claim 7 , BP claim 7 , C1 claim 7 , C2 claim 7 , E claim 7 , F claim 7 , TMZ or Z.15. The method according to claim 11 , comprising removing all substituents other than hydroxyl. The present invention relates to the preparation of compounds comprising two phenyl groups, such as bisphenol compounds.Bisphenol compounds comprise two hydroxyphenyl groups linked by ...

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Номер записи: 92
09-01-2020 дата публикации

Composition for Control and Inhibition of Polymerization of Monomers, and Method of Use and Preparation Thereof

Номер: US20200010386A1
Автор: Subramaniyam Mahesh
Принадлежит:

The present invention relates to an additive composition for controlling and inhibiting polymerization of monomers, wherein the composition comprises a combination of (a) a phenol compound comprising catechol compound with (b1) an aliphatic tertiary amine, (b2) oxide treated derivative of the aliphatic tertiary amine, or (b2) a mixture thereof, wherein the aliphatic tertiary amine contains one or more hydroxyl groups in the alkyl chain of the aliphatic tertiary amine. In one embodiment, the present invention also relates to a method for controlling and inhibiting polymerization of monomers by employing the additive composition of the present invention. In another embodiment, the present invention also relates to a method of using the additive composition of the present invention for controlling and inhibiting polymerization of monomers. In another embodiment, the present invention also relates to methods for controlling and inhibiting polymerization of monomers in a primary fractionator (or an ethylene plant), and for operating a primary fractionator, and for reducing fouling and polymer deposits in a primary fractionator, and to extend a run-length of a primary fractionator or of an ethylene plant. 1. An additive composition for control and inhibition of polymerization of monomers , wherein the composition consisting of a combination of:(a) a phenol compound comprising catechol compound; and(b) an amine selected from the group consisting of:(i) tri-isopropanol amine (TIPA);(ii) ethyl oxide treated derivative of tri-isopropanol amine (EO-TIPA);(iii) propyl oxide treated derivative of tri-isopropanol amine (PO-TIPA); or(iv) a mixture thereof.26-. (canceled)7. The additive composition as claimed in claim 1 , wherein the catechol compound comprises a tertiary butyl catechol (TBC).8. The additive composition as claimed in claim 1 , wherein the tertiary butyl catechol (TBC) is selected from the group comprising 4-tert-butyl catechol; 3 claim 1 ,5-di-tert-butylcatechol; ...

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Номер записи: 93
03-02-2022 дата публикации

Chromium-Catalyzed Production of Alcohols From Hydrocarbons

Номер: US20220033332A1
Автор: Carlos A. Cruz, Jared L. BARR, Kathy S. CLEAR, Masud M. Monwar, Max P. McDaniel, William C. Ellis
Принадлежит: Chevron Phillips Chemical Co LP

Processes for converting a hydrocarbon reactant into an alcohol compound and/or a carbonyl compound are disclosed, and these processes include the steps of forming a supported chromium catalyst comprising chromium in a hexavalent oxidation state, irradiating the hydrocarbon reactant and the supported chromium catalyst with a light beam at a wavelength in the UV-visible spectrum to reduce at least a portion of the supported chromium catalyst to form a reduced chromium catalyst, and hydrolyzing the reduced chromium catalyst to form a reaction product comprising the alcohol compound and/or the carbonyl compound. The supported chromium catalyst can be formed by heat treating a supported chromium precursor, contacting a chromium precursor with a solid support while heat treating, or heat treating a solid support and then contacting a chromium precursor with the solid support.

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Номер записи: 94
19-01-2017 дата публикации

NANOPOROUS FILMS DERIVED FROM POLYCYCLO-OLEFINIC BLOCK POLYMERS

Номер: US20170015790A1
Автор: Bell Andrew, Burtovyy Oleksandr, Vogt Bryan D., YE CHANGHUAI
Принадлежит:

A nanoporous film formed from a series of vinyl addition block polymers derived from functionalized norbornene monomers are disclosed and claimed. The nanoporous films as disclosed herein are useful as pervaporation membranes and antireflective coatings among various other uses. Also disclosed herein are the fabrication of nanoporous films into pervaporation membranes which exhibit unique separation properties, and their use in the separation of organic volatiles from biomass and/or organic waste, including butanol, phenol, and the like. The fabrication of nanoporous films into antireflective coatings are also disclosed. 3. The film according to claim 1 , wherein the diblock polymer is selected from the group consisting of:a diblock polymer derived from 5-hexylbicyclo[2.2.1]hept-2-ene and norbornenyl-2-trifluoromethyl-3,3,3-trifluoropropan-2-ol (HexNB-b-HFANB);a diblock polymer derived from 5-butylbicyclo[2.2.1]hept-2-ene and norbornenyl-2-trifluoromethyl-3,3,3-trifluoropropan-2-ol (BuNB-b-HFANB);a diblock polymer derived from 5-decylbicyclo[2.2.1]hept-2-ene and norbornenyl-2-trifluoromethyl-3,3,3-trifluoropropan-2-ol (DecNB-b-HFANB); anda diblock polymer of derived from norbornenyl-2-trifluoromethyl-3,3,3-trifluoropropan-2-ol and 2-(bicyclo[2.2.1]hept-5-en-2-yl)bicyclo[2.2.1]heptane (HFANB-b-NBANB).4. The film according to claim 2 , wherein the polymer is selected from the group consisting of:a triblock polymer derived from norbornenyl-2-trifluoromethyl-3,3,3-trifluoropropan-2-ol, 5-decylbicyclo[2.2.1]hept-2-ene and norbornenyl-2-trifluoromethyl-3,3,3-trifluoropropan-2-ol (HFANB-b-DecNB-b-HFANB);a triblock polymer derived from norbornenyl-2-trifluoromethyl-3,3,3-trifluoropropan-2-ol, 5-butylbicyclo[2.2.1]hept-2-ene, and norbornenyl-2-trifluoromethyl-3,3,3-trifluoropropan-2-ol (HFANB-b-BuNB-b-HFANB);a triblock polymer derived from norbornenyl-2-trifluoromethyl-3,3,3-trifluoropropan-2-ol, 5-octylbicyclo[2.2.1]hept-2-ene and 1-(4-(bicyclo[2.2.1]hept-5-en-2-yl)butyl)-3 ...

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Номер записи: 95
21-01-2016 дата публикации

Process For The Preparation Of Substituted TRIS(2-Hydroxyphenyl)Methane

Номер: US20160016871A1
Автор: Brand Fabien Jean, Gerster Michele, Hänggi Peter, HANSCH Markus
Принадлежит: Wintershall Holding GmbH

Described is a novel process for the preparation of substituted tris(2-hydroxyphenyl)methane derivatives and the use of tris(2-hydroxyphenyl)methane derivatives for tertiary mineral oil production.

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Номер записи: 96
18-01-2018 дата публикации

DECARBOXYLATION OF CANNABIDIOLIC ACID IN HEMP BIOMASS & HEMP EXTRACT

Номер: US20180016216A1
Автор: Leker Jeremy, Maye John Paul
Принадлежит:

Provided is a decarboxylating carboxylic acids of cannabinoids in hemp extract or hemp biomass in which the hemp extract or hemp biomass is heated to a temperature of 40° C. to 100° C. in the presence of one or more divalent or monovalent reagents. 1. A method for decarboxylating carboxylic acids of cannabinoids in hemp extract or hemp biomass which comprises heating the hemp extract or hemp biomass to a temperature of 40° C. to 100° C. in the presence of one or more divalent or monovalent reagents.2. The method of claim 1 , wherein the carboxylic acids of cannabinoids are selected from the group consisting of cannabidolic acid claim 1 , tetrahydrocannabonolic acid claim 1 , and mixtures thereof.3. The method of claim 1 , wherein the hemp extract comprises a super critical COextract or a Liquid COextract of hemp or a hemp biomass.4. The method of claim 1 , wherein the hemp extract comprises an organic solvent extract of hemp or a hemp biomass.5. The method of claim 4 , wherein the organic solvent extract comprises an alcohol extract or a hexane extract of hemp or a hemp biomass.6. The method of claim 5 , wherein the alcohol comprises a lower alcohol selected from the group consisting of methanol claim 5 , ethanol claim 5 , propanol and butanol.7. The method of claim 6 , wherein the alcohol is ethanol.8. The method of claim 1 , wherein the reagent used to perform the decarboxylation is selected from the group consisting of a divalent metal oxide claim 1 , a divalent metal hydroxide claim 1 , and divalent metal salts claim 1 , and a mixture thereof.9. The method of claim 8 , wherein the reagent is selected from the group consisting of MgO claim 8 , CaO claim 8 , ZnO claim 8 , Mg(OH) claim 8 , Ca(OH) claim 8 , CaCl claim 8 , MgSO4 claim 8 , MgSO4(HO) claim 8 , and ZnSO4 and a mixture thereof.10. The method of claim 1 , wherein a reagent used to perform the decarboxylation is selected from the group consisting of a sodium claim 1 , a potassium and a lithium monovalent ...

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Номер записи: 97
15-01-2015 дата публикации

METHOD FOR PREPARING A HERBICIDAL COMPOUND

Номер: US20150018569A1
Автор: Baird Mark Stephen, Braganca Radek Messias, Fowler Paul Anthony, Gould Spencer Matthew, Howard Frank Arthur, Tverezovskiy Viacheslav Vitalievich
Принадлежит: BANOR UNIVERSIITY

The present invention discloses a simple method for transforming cashew nut shell liquid into an active herbicidal composition. 2. The method of wherein R is alkyl having from 12 to 18 carbon atoms.3. The method of wherein R′ is alkyl having from 1 to 5 carbon atoms.4. The method of wherein R″ is hydrogen or alkyl having from 1 to 5 carbon atoms.6. The method of wherein alkylation step b) is carried out with alcohol R′OH wherein R′ is alkyl having up to 6 carbon atoms claim 1 , preferably methyl claim 1 , or with alkyl halide R′X wherein X is halogen claim 1 , or with alkyl sulfonate or alkyl sulfate claim 1 , or dialkyl sulfate claim 1 , optionally in a solvent.7. The method of wherein the alkylation step b) is carried out with dialkyl carbonate claim 6 , preferably dimethyl carbonate claim 6 , in the presence of a phase transfer catalyst.8. The method of wherein first oxidation step c) is carried out with oxygen claim 1 , or hydrogen peroxide claim 1 , or CrO claim 1 , or potassium permanganate claim 1 , or ferric chloride claim 1 , or potassium dichromate claim 1 , or nitric acid claim 1 , or with air in the presence of a catalyst selected from salcomine claim 1 , Pt claim 1 , Pd claim 1 , Ru claim 1 , Zr or Rh.9. The method of wherein Thiele (Thiele-Winter) acetoxylation step d) is carried out with acetic anhydride in the presence of sulfuric acid claim 1 , or triflic acid claim 1 , or bismuth triflate claim 1 , or acetic phosphoric anhydride or boron trifluoride.10. The method of wherein deacetylation step e) is carried out with lithium aluminium hydride or in the presence of a Lewis acid or with hydrochloric or another strong acid like sulphuric or para-toluenesulfonic acids in polar solvent.11. The method of wherein steps c claim 1 , d) claim 1 , and e) are replaced by a treatment with air or oxygen in the presence of a catalyst.12. The method of wherein the oxidizing is carried out with ferric chloride.13. The method of wherein the oxidizing is carried out ...

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Номер записи: 98
15-01-2015 дата публикации

Process for Producing Phenol

Номер: US20150018583A1
Автор: Becker Christopher L., Kuechler Keith H., Lattner James R., Nair Hari
Принадлежит:

In a process for producing phenol, benzene is reacted with a source of hydrogen containing methane in the presence of a hydroalkylation catalyst under conditions effective to produce a hydroalkylation reaction effluent comprising cyclohexylbenzene, benzene, hydrogen, and methane. A first stream comprising hydrogen, methane, and benzene is removed from the hydroalkylation reaction effluent and the first stream is washed with a second stream containing cyclohexylbenzene to produce a benzene-depleted hydrogen stream containing hydrogen and methane and a wash stream containing cyclohexylbenzene and benzene. 1. A process for producing phenol , the process comprising:(a) reacting benzene with a hydrogen-containing stream in the presence of a hydroalkylation catalyst under conditions effective to produce a hydroalkylation reaction effluent comprising cyclohexylbenzene, benzene, and hydrogen;(b) removing a first stream from the hydroalkylation reaction effluent, said first stream comprising hydrogen and benzene; and(c) washing at least a portion of the first stream with a second stream containing cyclohexylbenzene to produce a benzene-depleted hydrogen stream and a wash stream containing cyclohexylbenzene and benzene.2. The process of claim 1 , wherein the first stream is substantially in the vapor phase and the second stream is substantially in the liquid phase.3. The process of claim 1 , wherein at least 50 wt % of the benzene contained in said at least a portion of the first stream is transferred to the wash stream in said washing (c) claim 1 , the wt % based upon the weight of said at least a portion of the first stream.4. The process of claim 1 , wherein the second stream contains less than 1 wt % of benzene claim 1 , based upon the weight of the second stream.5. The process of claim 1 , wherein the benzene-depleted hydrogen stream contains less than 0.1 wt % benzene claim 1 , based upon the weight of the benzene-depleted hydrogen stream.6. The process of claim 1 , ...

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Номер записи: 99
16-01-2020 дата публикации

EXTRACTION OF CANNABINOIDS, CURCUMINOIDS AND GINSENOSIDES

Номер: US20200016508A1
Автор: Hari V., Stockwell John
Принадлежит:

An example method for extracting phytochemical oil from plant parts includes freezing plant parts from at least one of Cannabis sativa, Curcuma longa, Panax ginseng, and Panax quinquefolius. The frozen plant parts are reduced to a plant powder, which is suspended in an aqueous buffer. The aqueous buffer containing the suspended plant powder is incubated with at least one pectinase and at least one cellulose. An aqueous phase of the incubated aqueous buffer is evaporated through steam heating to obtain a steam dried product. Phytochemical oil, which includes at least one of cannabinoids, curcuminoids, and ginsenosides, is extracted from the steam dried product. 1. A method for extracting phytochemical oil from plant parts , comprising:freezing plant parts from at least one of Cannabis sativa, Curcuma longa, Panax ginseng, and Panax quinquefolius;reducing the frozen plant parts to a plant powder;suspending the plant powder in an aqueous buffer;incubating the aqueous buffer containing the suspended plant powder with at least one pectinase and at least one cellulase;evaporating an aqueous phase of the incubated aqueous buffer through steam heating to obtain a steam dried product; andextracting phytochemical oil from the steam dried product, the phytochemical oil including at least one of cannabinoids, curcuminoids, and ginsenosides.2. The method of claim 1 , comprising claim 1 , prior to said freezing:sanitizing the plant parts, the sanitizing including at least one of washing, ultraviolet irradiation, and ozonolysis.3. The method of claim 2 , wherein said washing and disinfecting removes microorganisms from the plant parts.4. The method of claim 3 , wherein said reducing the frozen plant parts to a plant powder comprises pulverizing the frozen plant parts.5. The method of claim 1 , wherein:said freezing comprises cooling the plant parts with dry ice; andsaid reducing is performed while the plant parts are being cooled by the dry ice.6. The method of claim 1 , wherein ...

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Номер записи: 100