2-[1-Cyanopropyl)Carbamoyl]-5-Chloromethyl Nicotinic Acids and the Use Thereof in Manufacturing Herbicidal Imidazolinones

... 2-[(1-cyanopropyl)carbamoyl]-5-chloromethyl nicotinic acids of formula (I) where Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; R1 is C1-C4 alkyl; R2 is C1-C4 alkyl, C3-C6 cycloalkyl or R1 and R2, when taken together with the atom to which they are attached, represent a C3-C6 cycloalkyl group optionally substituted with methyl, and R3 is hydrogen or a cation preferably selected from the group consisting of alkali metals, alkaline earth metals, manganese, copper, iron, zinc, cobalt, lead, silver, nickel, ammonium and organic ammonium; are useful intermediates for the synthesis of herbicidal imidazolinones.

Process for producing 2,5-dihalophenolethers

The present invention relates to a process for providing a compound of formula (IV): wherein R 1 and R 2 are each independently C 1 -C 4 alkyl, and Hal is independently Cl or Br, the process comprising the steps of: (i) reacting a compound of formula (II) wherein R 1 and Hal is defined as above, to obtain a compound of formula (III) wherein R 1 and Hal is defined as above, and (ii) reacting the compound of formula (III) to obtain the compound of formula (IV).

Process for Manufacturing 5-Formyl-Pyridine-2,3-Dicarboxylic Acid Esters

A process for manufacturing a 5-formyl-pyridine-2,3-dicarboxylic acid ester (I) wherein Z is hydrogen or halogen; Z 1 is hydrogen, halogen, cyano or nitro and R 1 , R 2 are independently C 1 -C 10 -alkyl, comprising the steps of (i) reacting a compound of formula (II), wherein the symbols are as in formula (I), with a nitrosation agent (III) R 3 —O—N═O (III) wherein R 3 is C 1 -C 8 -alkyl, in the presence of an alkali metal or alkaline earth metal alcoholates or carbonates in a polar aprotic solvent at a temperature of from −45 to 40° C., to obtain an oxime compound (IV) where Z, Z 1 , R 1 and R 2 are as in formula (I), and (ii) reacting oxime compound (IV) with an aliphatic C 1 -C 10 -aldehyde in the presence of a Lewis acid at a temperature in the range of from 0 to 100° C. The compounds of formula (I) are useful intermediates in the synthesis of herbicidal imidazolinones, like imazamox.

Process for manufacturing 5-formyl-pyridine-2,3-dicarboxylic acid esters

A process for manufacturing a 5-formyl-pyridine-2,3-dicarboxylic acid ester (I) wherein Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro and R1, R2 are independently C1-C10-alkyl, comprising the steps of (i) reacting a compound of formula (II), wherein the symbols are as in formula (I), with a nitrosation agent (III) R3-O-N=O (III) wherein R3 is C1-C8-alkyl, in the presence of an alkali metal or alkaline earth metal alcoholates or carbonates in a polar aprotic solvent at a temperature of from -45 to 40° C., to obtain an oxime compound (IV) where Z, Z1, R1 and R2 are as in formula (I), and (ii) reacting oxime compound (IV) with an aliphatic C1-C10-aldehyde in the presence of a Lewis acid at a temperature in the range of from 0 to 100° C. The compounds of formula (I) are useful intermediates in the synthesis of herbicidal imidazolinones, like imazamox.

2-[1-cyanopropyl)carbamoyl]-5-chloromethyl nicotinic acids and the use thereof in manufacturing herbicidal imidazolinones

... 2-[(1-cyanopropyl)carbamoyl]-5-chloromethyl nicotinic acids of formula (I) where Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; R1 is C1-C4 alkyl; R2 is C1-C4 alkyl, C3-C6 cycloalkyl or R1 and R2, when taken together with the atom to which they are attached, represent a C3-C6 cycloalkyl group optionally substituted with methyl, and R3 is hydrogen or a cation preferably selected from the group consisting of alkali metals, alkaline earth metals, manganese, copper, iron, zinc, cobalt, lead, silver, nickel, ammonium and organic ammonium; are useful intermediates for the synthesis of herbicidal imidazolinones.

Process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides

A process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides (I) wherein Z is hydrogen or halogen; Z 1 is hydrogen, halogen, cyano or nitro; comprising the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with a chlorinating agent, optionally in the presence of a radical initiator in a solvent selected from halogenated hydrocarbons, and (ii) crystallizing the compound (I) formed in step (i) from a solvent selected from chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, dichloroethane, trichloromethane, dichloromethane, toluene, xylenes, ethyl acetate, methyl tert.-butyl ether, and mixtures thereof. Compounds (I) are useful intermediates in the synthesis of herbicidal imidazolinones.

Process for Manufacturing 5-Chloromethyl-2,3-Pyridine Dicarboxylic Acid Anhydrides

A process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides (I) wherein Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; comprising the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with a chlorinating agent, optionally in the presence of a radical initiator in a solvent selected from halogenated hydrocarbons, and (ii) crystallizing the compound (I) formed in step (i) from a solvent selected from chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, dichloroethane, trichloromethane, dichloromethane, toluene, xylenes, ethyl acetate, methyl tert.-butyl ether, and mixtures thereof. Compounds (I) are useful intermediates in the synthesis of herbicidal imidazolinones.

Process for manufacturing substituted 3-pyridylmethyl ammonium bromides

A process for manufacturing 5,6-disubstituted-3-pyridylmethyl ammonium bromides (I), wherein Q is a tertiary aliphatic or cyclic, saturated, partially unsaturated or aromatic amine; Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; Y and Y1 are each independently OR1, NR1R2, or when taken together YY1 is O, S or NR3; R1 and R2 are each independently hydrogen, C1-C4 alkyl optionally substituted with C1-C4 alkoxy or phenyl optionally substituted with one to three C1-C4 alkyl groups, C1-C4 alkoxy groups or halogen atoms, or phenyl optionally substituted with one to three C1-C4 alkyl groups, C1-C4 alkoxy groups or halogen atoms; R3 is hydrogen or C1-C4 alkyl; comprises the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with bromine in the presence of a radical initiator in a solvent mixture comprising an aqueous phase and an organic phase, where the organic phase comprises a solvent selected from 1,2-dichloroethane ...

Process for providing dihalogen substituted salicylic acid derivatives

The present invention relates to a process for providing dihalogen substituted salicylic acid derivatives of formula (II): ...

Process for Manufacturing Substituted 5-Methoxymethylpyridine-2,3-Dicarboxylic Acid Derivatives

A process for manufacturing a 2,3-disubstituted-5-methoxymethylpyridine of formula (I), where Z is H or halogen; Z1 is H, halogen, CN or NO2; Y2 is OM, and M is an alkali metal or an alkaline earth metal, comprises the step of: (i) reacting a compound of formula (II) where Q is a tertiary aliphatic or cyclic, saturated, partially unsaturated or aromatic amine; Z is H or halogen; Z1 is H, halogen, CN or NO2; Y1 and Y2 are each independently OR1, NR1R2, or when taken together Y1Y2 is O, S or NR3; R1 and R2 are each independently H, C1-C4 alkyl optionally substituted with C1-C1 alkoxy or phenyl optionally substituted with one to three C1-C4 alkyl groups, C1-C4 alkoxy groups or halogen atoms, or phenyl optionally substituted with one to three C1-C4 alkyl groups, C1-C4 alkoxy groups or halogen atoms; R3 is H or C1-C4 alkyl, in a methanol/H2O mixture, comprising at least 20% by weight H2O (based on the sum of water and bromide (II)), with a base comprising MOCH3 and/or MOH, where M is alkali ...

Process for hydrolyzing 1,2,4-trihalobenzene

The present invention relates to a process for providing a compound of formula (I): wherein Hal is a halogen, the process comprising the step of: reacting a compound of formula (II) wherein Hal is defined as above, with an alkali metal sulfite of the formula X 2 SO 3 and an alkali metal hydroxide of the formula YOH, wherein X and Y are independently selected from an alkali metal.

Process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides

A process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides (I) wherein Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; comprising the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with a chlorinating agent, optionally in the presence of a radical initiator in a solvent selected from halogenated hydrocarbons, and (ii) crystallizing the compound (I) formed in step (i) from a solvent selected from chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, dichloroethane, trichloromethane, dichloromethane, toluene, xylenes, ethyl acetate, methyl tert.-butyl ether, and mixtures thereof. Compounds (I) are useful intermediates in the synthesis of herbicidal imidazolinones.

Process for Manufacturing Substituted 3-pyridylmethyl Ammonium Bromides

A process for manufacturing 5,6-disubstituted-3-pyridylmethyl ammonium bromides (I), wherein Q is a tertiary aliphatic or cyclic, saturated, partially unsaturated or aromatic amine; Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; Y and Y1 are each independently OR1, NR1R2, or when taken together YY1 is O, S or NR3; R1 and R2 are each independently hydrogen, C1-C4 alkyl optionally substituted with C1-C4 alkoxy or phenyl optionally substituted with one to three C1-C4 alkyl groups, C1-C4 alkoxy groups or halogen atoms, or phenyl optionally substituted with one to three C1-C4 alkyl groups, C1-C4 alkoxy groups or halogen atoms; R3 is hydrogen or C1-C4 alkyl; comprises the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with bromine in the presence of a radical initiator in a solvent mixture comprising an aqueous phase and an organic phase, where the organic phase comprises a solvent selected from 1,2-dichloroethane ...

Selective hydrolysis and alcoholysis of chlorinated benzenes

The present invention relates to a process for providing a compound of formula (I): wherein R is hydrogen or R′, wherein R′ is —(C1-C4)alkyl, and Hal is a halogen, the process comprising the step of: reacting a compound of formula (II) wherein Hal is defined as above, with an alkali metal alkoxide of the formula XOR′, wherein X is an alkali metal, and R′ is defined as above.

Process for manufacturing substituted 5-methoxymethylpyridine-2,3-dicarboxylic acid derivatives

A process for manufacturing a compound of formula (I), Comprising reacting a compound of formula (II) in a methanol/H2O mixture. Compounds of formula (I) are useful intermediates in the synthesis of herbicidal imidazolinones, like imazamox.

Process for purifying 2,5-dichlorophenol

A process for purifying 2,5-dichlorophenol, the process comprising the steps of distillation and subsequent crystallization.

BOND WIRE TRANSFORMER

A bond wire transformer comprises a plurality of primary bond wires coupled in parallel; and a plurality of secondary bond wires coupled in parallel, each secondary bond wire being spaced apart from and oriented relative to a corresponding primary bond wire so as to achieve a desired mutual inductance between the corresponding primary and secondary bond wires, thereby providing magnetic coupling between the primary and secondary bond wires. 1. A bond wire transformer comprising a plurality of primary bond wires coupled in parallel; and a plurality of secondary bond wires coupled in parallel , each secondary bond wire being spaced apart from and oriented relative to a corresponding primary bond wire so as to achieve a desired mutual inductance between the corresponding primary and secondary bond wires , thereby providing magnetic coupling between the primary and secondary bond wires.2. A bond wire transformer according to claim 1 , wherein the number of primary bond wires is the same as the number of secondary bond wires.3. A bond wire transformer according to claim 1 , wherein each of the primary bond wires is connected between first and second common bonding pads.4. A bond wire transformer according to claim 1 , wherein the primary bond wires are connected to nodes of a circuit such that the signals flowing in each of the primary bond wires are substantially the same.5. A bond wire transformer according to claim 1 , wherein each of the secondary bond wires is connected between first and second common bonding pads to form a first section of the secondary bond wire.64. A bond wire transformer according to when dependent on claim 1 , further comprising a third common bonding pad claim 1 , each of the secondary bond wires extending from the second common bonding pad to the third common bonding pad to form a second section of the secondary bond wire () claim 1 , whereby each of the first and second sections contribute to achieving the desired mutual inductance between ...

Process for producing 2,5-dihalophenolethers

The present invention relates to a process for providing a compound of formula (IV): wherein R 1 and R 2 are each independently C 1 -C 4 alkyl, and Hal is independently Cl or Br, the process comprising the steps of: (i) reacting a compound of formula (II) wherein R 1 and Hal is defined as above, to obtain a compound of formula (III) wherein R 1 and Hal is defined as above, and (ii) reacting the compound of formula (III) to obtain the compound of formula (IV).

PRODUCTION OF ARYLPYRROL COMPOUNDS IN THE PRESENCE OF DIPEA BASE

A process A for the production of compounds of formula I is provided. 2. The process according to claim 1 , wherein the Step A is carried out in a solvent comprising a polar aprotic solvent.3. The process according to claim 1 , wherein compounds of formula I are produced by reaction of compounds of formula II with 2 claim 1 ,3-dichloropropionitrile.5. The process according to claim 4 , wherein Step B is carried out in in a solvent comprising a polar aprotic solvent.6. (canceled)7. The process according to claim 4 , wherein steps A and B are carried out as a one-pot process.8. The processes process according to claim 1 , wherein Ris para-chlorophenyl claim 1 , and n is 1.10. The process according to claim 9 , wherein Ris p-chlorophenyl claim 9 , n is 1 claim 9 , and Ris CHCHOCH.11. The process according to claim 9 , wherein Step C is carried out in a solvent comprising aliphatic C-C-hydrocarbons claim 9 , an aromatic C-C-hydrocarbons claim 9 , halogenated aliphatic C-C-alkanes claim 9 , halogenated aromatic C-C-hydrocarbons claim 9 , C-C-nitriles claim 9 , DMF claim 9 , or a mixture thereof.12. (canceled)14. The process according to claim 13 , wherein Step D and Step A are carried out in a one-pot process.16. The process according to claim 2 , wherein the Step A is carried out in a solvent comprising acetonitrile.17. The process according to claim 5 , wherein Step B is carried out in in a solvent comprising acetonitrile. The invention relates to Process A for the production of compounds of formula Iwherein the variables have the same meaning as defined for compounds of formula I; with 2,3-dihalopropionitrile (DHPN) or 2-haloacrylonitrile (HACN) in the presence of diisopropylethylamine (DIPEA).The invention also relates to Process B for the production of compounds of formula IIIwherein the variables have a meaning as defined for compounds of formula I; comprising Step B of reacting compounds of formula I with Br(bromine) in the presence of DIPEA.It also relates to ...

Process for Manufacturing 5-Chloromethyl-2,3-Pyridine Dicarboxylic Acid Anhydrides

A process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides (I) 2. The process as claimed in claim 1 , where the solvent in step (i) is selected from chlorinated hydrocarbons.3. The process as claimed in claim 1 , where the solvent in step (i) is selected from halogenated aliphatic or aromatic hydrocarbons.4. The process as claimed in claim 1 , where the solvent in step (i) is selected from 1 claim 1 ,2-dichloroethane claim 1 , chlorobenzene claim 1 , 1 claim 1 ,2-dichlorobenzene claim 1 , 1 claim 1 ,3-dichlorobenzene claim 1 , 1 claim 1 ,4-dichlorobenzene claim 1 , tetrachloromethane claim 1 , and mixtures thereof.5. The process as claimed in claim 4 , where the solvent in step (i) is selected from 1 claim 4 ,2-dichloroethane claim 4 , chlorobenzene claim 4 , 1 claim 4 ,2-dichlorobenzene claim 4 , 1 claim 4 ,3-dichlorobenzene claim 4 , 1 claim 4 ,4-dichlorobenzene claim 4 , and mixtures thereof.6. The process as claimed in claim 5 , where the solvent in step (i) is selected from chlorobenzene and dichlorobenzenes.7. The process as claimed in claim 1 , where the solvent in step (ii) is selected from chlorobenzene and dichlorobenzenes.8. The process as claimed in claim 1 , where the solvent in steps (i) and (ii) are identical.9. The process as claimed in claim 8 , where the solvent in steps (i) and (ii) is chlorobenzene.10. The process as claimed in where compound (I) is recrystallized after initial crystallization.1315-. (canceled) The invention relates to a process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides and further conversion of these compounds to herbicidal 5-substituted-2-(2-imidazolin-2-yl)nicotinic acids, such as imazamox.Derivatives of 2-(2-imidazolin-2-yl) nicotinic acids, like imazamox (2-[(RS)-4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl}-5-methoxymethyl nicotinic acid),are useful selective herbicides which act as ALS-inhibitors and can be used in pre- and post-emergence applications.Various ...

MANAGING THE CARE OF A CLIENT IN A CARE MANAGEMENT SYSTEM

A care management system for improving the care of a client who is supported by a caregiver is described. The caregiver may participate in regular activities with the client and record these activities in the care management system. The care management system may present the caregiver with questions on a regular basis. Information may also be input into the system by a care management team made up of professionals responsible for the client's overall care. A risk analyzer may determine the client's risk for different risk conditions, and may calculate domain-specific and overall risk scores for the client. Furthermore, the risk analyzer may make recommendations for actions to be taken by the client, the caregiver, or the care management team in order to improve the client's care. The information in the care management system may be used by the care management team to direct aspects of the client's care. 1. A non-transitory computer-readable medium storing instructions that , when executed by a processor , cause the processor to:receiving first authentication credentials for a first user;displaying a first interface for the first user, the first interface accepting first input data in a first domain that describes an aspect of a client's overall health;receiving the first input data from the first user through the first interface;storing the first input data in a data storage mechanism;calculating a first risk score based on the first input data;receiving second authentication credentials for a second user; the second interface differs from the first interface, and', 'the second domain differs from the first domain;, 'displaying a second interface for the second user, the second interface accepting second input data in a second domain, whereinreceiving the second input data from the second user through the second interface;storing the second input data in the data storage mechanism;calculating a second risk score based on the second input data;aggregating the first ...

RISK MODEL FOR A CARE MANAGEMENT SYSTEM

A care management system for improving the care of a client who is supported by a caregiver is described. The caregiver may participate in regular activities with the client and record these activities in the care management system. The care management system may present the caregiver with questions on a regular basis. Information may also be input into the system by a care management team made up of professionals responsible for the client's overall care. A risk analyzer may determine the client's risk for different risk conditions, and may calculate domain-specific and overall risk scores for the client. Furthermore, the risk analyzer may make recommendations for actions to be taken by the client, the caregiver, or the care management team in order to improve the client's care. The information in the care management system may be used by the care management team to direct aspects of the client's care. 1. A non-transitory electronic device readable medium storing instructions that , when executed by one or more processors , cause the one or more processors to:identify a profile of a client, the profile specifying demographic or historical information about a status of a client;present one or more structured questions on an interface relating to a status of the client;accept structured inputs from a caregiver relating to the status of the client;analyze the structured inputs based on information in the profile to determine a risk value for the client in one or more domains; andstore the risk value.2. The medium of claim 1 , further storing instructions for:presenting an activity log relating to the regular activities of the client on an interface; andaccepting activity data through the interface, the activity data comprising a level of support provided to the client by the caregiver in performing the regular activities, wherein the risk value is further determined based on the activity data.3. The medium of claim 1 , further storing instructions for:presenting a ...

RULES-BASED SYSTEM FOR CARE MANAGEMENT

A care management system for improving the care of a client who is supported by a caregiver is described. The caregiver may participate in regular activities with the client and record these activities in the care management system. The care management system may present the caregiver with questions on a regular basis. Information may also be input into the system by a care management team made up of professionals responsible for the client's overall care. A risk analyzer may determine the client's risk for different risk conditions, and may calculate domain-specific and overall risk scores for the client. Furthermore, the risk analyzer may make recommendations for actions to be taken by the client, the caregiver, or the care management team in order to improve the client's care. The information in the care management system may be used by the care management team to direct aspects of the client's care. 1. A non-transitory computer-readable medium storing instructions that , when executed by a processor of a computer , cause the processor to:select one or more questions from a question database, the question database comprising structured questions and a plurality of structured answers for each question and being subdivided into a plurality of domains related to home-based care of a client, wherein the questions are selected in a custom order by a risk analyzer based on known information about the client's risk for conditions evaluated by the questions;present the selected questions on an interface;receive a selection of one or more answers from among the plurality of structured answers; andprovide the selected one or more answers to the risk analyzer that uses the selected one or more answers to calculate risk scores for the plurality of domains.2. The medium of claim 1 , wherein the plurality of domains are selected from a group consisting of:a functional domain relating to an ability of the client to function in daily life;a medical domain relating to a medical ...

SYSTEM AND METHOD FOR TRANSMITTING DIGITAL MULTIMEDIA DATA WITH ANALOG BROADCAST DATA

A method and system for the transmission of digital data () over existing analog radio frequencies () is presented, wherein the digital data may include audio data, visual data or audio-visual data for presentation either with analog broadcast data or at a selectable time. The digital data may be transmitted over a plurality of sub-channels that have varying degrees or reliability (). A “quality-of-service” process manages the transmission of digital data over various sub-channels based on the reliability of the sub-channel, the amount of digital data and the type of digital data to be transmitted. The digital data may further be encrypted and authenticated. 1. A method of transmitting digital data on at least one RF carrier of an audio broadcast , comprising:identifying digital data associated with, but different than a set of broadcast data;determining synchronization data corresponding to a broadcast event within the set of broadcast data;assembling a data packet including the digital data and the synchronization data; andtransmitting the data packet to a receiver before the broadcast event, such that the broadcast data is presented with the digital data based on the synchronization data to a consumer of the broadcast data.2. The method of claim 1 , wherein the digital data corresponds to multimedia information for display on a receiver.3. The method of wherein the multimedia information may be stored on the receiver for recall by a user at a desired time.4. The method of claim 1 , wherein said transmitting further comprises transmitting the data packet in a digital format on at least one RF carrier of a central analog frequency on which the broadcast data is transmitted.5. The method of further comprising transmitting the broadcast data on a central analog frequency.6. The method of further comprising determining authentication data for allowing a receiver to authenticate the data packet.7. The method of wherein assembling further comprises including the ...

SYSTEM AND METHOD FOR GENERATING MULTIMEDIA ACCOMPANIMENTS TO BROADCAST DATA

A method and system is presented for coordinating the transmission of supplemental digital data to accompany broadcast data, and in particular, analog radio broadcasts, among a plurality of broadcasters. The supplemental digital data may provide information about the particular broadcast data being transmitted or may be supplemental to such data. The supplemental digital data to be presented is sorted based on particular algorithms which may take into account broadcaster-specified criteria such as target audience, time of day, type of broadcast data presented, and the like. The supplemental digital data may be audio data, visual data, or audio-visual data for presentation with the broadcast data. The supplemental digital data may further be advertisement data. The advertisement data may be sold by the broadcasters or the party coordinating the IBOC transmission of the supplemental digital data. The supplemental digital data may play simultaneously with muted broadcast data or at a user-specified time. 1. An apparatus for entering into a commercial transaction to purchase a song comprising:a receiver configured to receive supplemental digital data and broadcast data, the supplemental digital data comprising a song title, artist information, and an action code, wherein the supplemental digital data is synchronized with the broadcast data and the action code comprises information for entering into a commercial transaction to purchase the song identified by the action code; and a processor; and', 'memory in communication with the processor, the memory usable for storing a plurality of processing instructions; and', control output of the song through a speaker associated with the receiver;', 'display at least one of the song title and artist on a display associated with the receiver;', 'receive an first indication from a user that the user desires to purchase the song; and', 'transmit a second indication to a system for purchasing the song on behalf of the user., ' ...

RADIO FREQUENCY FRONT-END PROTECTION WITH TUNABLE COUPLER

A radio frequency front-end includes a power amplifier. The radio frequency front-end also includes a coupler implemented in at least a portion of a matching circuit, the matching circuit coupled to an output of the power amplifier. The radio frequency front-end further includes a control loop comprising a first feedback terminal at an output of the power amplifier. The control loop includes the coupler coupled to the first feedback terminal of the power amplifier and is configured to generate a feedback signal provided to a second feedback terminal to adjust a gain of the power amplifier. The feedback signal is based on a reflected radio frequency signal provided by the coupler. 1. A radio frequency front-end comprising:a power amplifier having an output coupled to a first feedback terminal;a coupler including a tunable load, the coupler implemented in at least a portion of a matching circuit coupled to an output of the power amplifier; anda control loop comprising a first feedback terminal at an output of the power amplifier, the control loop comprising the coupler coupled to the first feedback terminal of the power amplifier and configured to generate a feedback signal based on a reflected radio frequency signal provided by the coupler; anda comparator having a first input configured to receive the feedback signal, a second input coupled to a tunable reference voltage, and an output coupled a second feedback terminal, the second feedback terminal configured to adjust a gain of the power amplifier based on the feedback signal and the tunable reference voltage.2. The radio frequency front-end of claim 1 , wherein the tunable load is configured to tune to a first impedance at an output of the power amplifier based on a specified frequency for transmission.3. The radio frequency front-end of claim 2 , in which the first impedance comprises a duplexer allocated for transmission in the specified frequency.4. The radio frequency front-end of claim 1 , in which the ...

Process for Manufacturing Substituted 5-Methoxymethylpyridine-2,3-Dicarboxylic Acid Derivatives

A process for manufacturing a compound of formula (I), 1. (canceled)5. The process of claim 2 , wherein the ratio of methanol to compound of formula (II) is in the range of from 0.5-25:1.6. The process of claim 2 , wherein the base is a mixture of MeOM and MOH.7. The process of claim 2 , wherein the base is MeOM.8. The process of wherein the molar ratio of MeOM to compound of formula (II) is in the range of from 1-2:1.9. The process of claim 7 , wherein the molar ratio of MeOM to compound of formula (II) is in the range of from 3-5:1.10. The process of claim 2 , wherein the base is MOH.11. The process of claim 6 , wherein the molar ratio of MOH to compound of formula (II) is in the range of from 1-5:1.12. The process of claim 10 , wherein the molar ratio of MOH to compound of formula (II) is in the range of from 4-7:1.13. The process of claim 2 , wherein the reaction temperature is in the range of from about 80 to 100° C.14. The process of claim 2 , which is carried out at a pressure of 1.01 to 5.00 bar. The invention relates to a process for manufacturing 5-methoxymethylpyridine-2,3-dicarboxylic acid derivatives and further conversion of these compounds to herbicidal 5-substituted-2-(2-imidazolin-2-yl) nicotinic acids, such as imazamox.Derivatives of 2-(2-imidazolin-2-yl) nicotinic acids, like imazamox (2-[(RS)-4-isopropyl-4-methyl-5-oxo-2-imidazolin-2-yl]-5-methoxymethylnicotinic acid),are useful selective herbicides which act as ALS-inhibitors and can be used in pre- and post-emergence applications.Various processes for the synthesis of these compounds are known from the literature, see e.g. EP-A 0 322 616, U.S. Pat. No. 5,378,843, U.S. Pat. No. 5,760,239, EP-A 0 933 362 or Q. Bi et al, Modern Agrochemicals 6(2)(2007) 10-14.U.S. Pat. No. 5,378,843 discloses the synthesis of 5-(mehoxymethyl)-2,3-pyridinedicarboxylic acid by reaction of [(5,6-dicarboxy-3-pyridyl)methyl] trimethylammonium bromide di-methyl ester with sodium methoxide/methanol and NaOH/water, ...

System and method for generating multimedia accompaniments to broadcast data

A method and system is presented for coordinating the transmission of supplemental digital data to accompany broadcast data, and in particular, analog radio broadcasts, among a plurality of broadcasters. The supplemental digital data may provide information about the particular broadcast data being transmitted (i.e. cut data) or may be supplemental to such data (i.e. news, weather and traffic data). The supplemental digital data to be presented is sorted based on particular algorithms which may take into account broadcaster-specified criteria such as target audience, time of day, type of broadcast data presented, and the like. The supplemental digital data may be audio data, visual data, or audio-visual data for presentation with the broadcast data. The supplemental digital data may further be advertisement data. The advertisement data may be sold by the broadcasters or the party coordinating the IBOC transmission of the supplemental digital data. The supplemental digital data may play simultaneously with muted broadcast data or at a user-specified time.

Process for Hydrolyzing 1,2,4-trihalobenzene

The present invention relates to a process for providing a compound of formula (I): 110-. (canceled)12. The process of claim 11 , wherein the process is carried out in the presence of water.13. The process of claim 12 , wherein the process is carried out in the presence of a C-Calcohol.14. The process of claim 13 , wherein the process is carried in the absence of organic solvents apart from the optional presence of a C-Calcohol.15. The process of claim 11 , wherein the process is carried out in in the absence of organic solvents.16. The process of claim 11 , wherein about one molar equivalent of the compound of formula (II) is reacted in the presence of{'sub': 2', '3, 'b': '1', '(a) about 1.0 to about 1.4 molar equivalents of an alkali metal sulfite of formula XSO, wherein X is as defined in claim ; and/or'}{'b': '1', '(b) about 0.5 to about 4.0 molar equivalents of an alkali metal hydroxide of formula YOH, wherein Y is as defined in claim ; and/or'}(c) about 20 to about 40 molar equivalents of water; and/or{'sub': 1', '4', '1', '4, '(d) up to 3 molar equivalents of a C-Calcohol, wherein apart from the C-Calcohol no further organic solvent is present.'}17. The process of claim 11 , wherein the step of reacting the compound of formula (II) is carried out at a(a) temperature of at least about 250° C.; and/or(b) pressure of about 2050 kPa to about 5600 kPa.19. The process of claim 18 , wherein the step of reacting the compound of formula (I) to obtain a compound of formula (III) is carried out in the presence of an alkali metal hydroxide and carbon dioxide.22. The process of claim 11 , wherein(a) Hal is selected from the group consisting of F, Cl, Br and I; and/or(b) X and Y are independently selected from sodium or potassium; and/or{'sup': '1', '(c) Ris selected from sodium and potassium; and/or'}{'sup': 1′', '1′, '(d) R is selected from sodium and potassium, or R is selected from ethyl and methyl.'}24. The process of claim 23 , wherein the process is carried out in ...

SELECTIVE HYDROLYSIS AND ALCOHOLYSIS OF CHLORINATED BENZENES

The present invention relates to a process for providing a compound of formula (I): 114-. (canceled)16. The process according to , wherein the process is carried out in a solvent , wherein the solvent is an alcohol of formula HOR′ , wherein R′ is as defined in .17. The process according to claim 15 , wherein the concentration of the alcoholic alkali metal alkoxide solution added to the reaction mixture is 25 wt.-% to 67 wt.-% claim 15 , based on the weight of the total weight of the alcohol HOR′ and the alkali metal alkoxide of the formula XOR′.18. The process according to claim 15 , wherein about one molar equivalent of the compound of formula (II) is reacted in the presence of 2 to 3 molar equivalents of the alkali metal alkoxide of formula XOR′ in 2 to 14 molar equivalents of a solvent of formula HOR′.19. The process according to claim 18 , wherein about one molar equivalent of the compound of formula (II) is reacted in the presence of 2.2 to 2.6 molar equivalents of the alkali metal alkoxide of formula XOR′ in 11.5 to 12.5 molar equivalents of a solvent of formula HOR′.20. The process according to claim 19 , wherein about one molar equivalent of the compound of formula (II) is reacted in the presence of about 2.4 molar equivalents of the alkali metal alkoxide of formula XOR′ in about 12 molar equivalents of a solvent of formula HOR′.21. The process according to claim 15 , wherein the step of reacting the compound of formula (II) with an alkali metal alkoxide of formula XOR′ is carried out at a temperature of at least 150° C.22. The process according to claim 21 , wherein the step of reacting the compound of formula (II) with an alkali metal alkoxide of formula XOR′ is carried out at 150° C. to 190° C.23. The process according to claim 15 , wherein the step of reacting the compound of formula (II) with an alkali metal alkoxide of formula XOR′ is carried out within 30 to 180 minutes.24. The process according to claim 23 , wherein the step of reacting the compound ...

SYSTEM AND METHOD FOR TRANSMITTING DIGITAL MULTIMEDIA DATA WITH ANALOG BROADCAST DATA

A method and system for the transmission of digital data () over existing analog radio frequencies () is presented, wherein the digital data may include audio data, visual data or audio-visual data for presentation either with analog broadcast data or at a selectable time. The digital data may be transmitted over a plurality of sub-channels that have varying degrees or reliability (). A “quality-of-service” process manages the transmission of digital data over various sub-channels based on the reliability of the sub-channel, the amount of digital data and the type of digital data to be transmitted. The digital data may further be encrypted and authenticated. 1identifying digital data associated with, but different than a set of broadcast data;determining synchronization data corresponding to a broadcast event within the set of broadcast data;assembling a data packet including the digital data and the synchronization data; andtransmitting the data packet to a receiver before the broadcast event, such that the broadcast data is presented with the digital data based on the synchronization data to a consumer of the broadcast data.. A method of transmitting digital data on at least one RF carrier of an audio broadcast, comprising: This application is a continuation of U.S. patent application Ser. No. 13/795,229, filed Mar. 12, 2013, now U.S. Pat. No. ______.The '229 application is a continuation of U.S. patent application Ser. No. 10/484,518 filed Dec. 2, 2004, now U.S. Pat. No. 8,396,100.The '518 application is a 371 of PCT US02/22898, filed Jul. 17, 2002.The '898 PCT application claims the benefit of and priority to U.S. Provisional Patent Application Ser. No. 60/306,080, filed Jul. 17, 2001, U.S. Provisional Patent Application Ser. No. 60/346,784, filed Jan. 7, 2002, and U.S. Provisional Patent Application Ser. No. 60/346,785, filed Jan. 7, 2002.The '518 application is also a continuation-in-part of U.S. patent application Ser. No. 09/839,451, filed Apr. 20, 2001, now ...

Process for Purifying 2,5-Dichlorophenol

A process for purifying 2,5-dichlorophenol, the process comprising the steps of distillation and subsequent crystallization. 19-. (canceled)10. A process for purifying 2 ,5-dichlorophenol , the process comprising the steps of:(i) subjecting a mixture (M) comprising 2,5-dichlorophenol, 2,4-dichlorophenol and optionally 3,4-dichlorophenol to distillation to obtain a distillate (D), and(ii) subjecting the distillate (D) to a crystallization step to obtain a crystalline fraction (C) and a mother liquor (L).11. The process of claim 10 , further comprising the step of:(iii) combining a composition obtained from the mother liquor (L) in step (ii) with a feed (F), comprising 2,5-dichlorophenol, 2,4-dichlorophenol and optionally 3,4-dichlorophenol, to obtain mixture (M) to be subjected to distillation in step (i).12. The process of claim 11 , wherein the feed (F) is obtained from hydrolyzing 1 claim 11 ,2 claim 11 ,4-trichlorophenol in the presence of an alkali metal hydroxide or alkali metal alkoxide.13. The process of claim 11 , wherein the mixture (M) and/or the feed (F) comprises 40 to 95 wt.-% of 2 claim 11 ,5-dichlorophenol; 5 to 60 wt.-% of 2 claim 11 ,4-dichlorophenol; and optionally 0 to 30 wt.-% of 3 claim 11 ,4-dichlorophenol.14. The process of claim 10 , wherein the distillate (D) obtained in step (i) comprises 50 to 95 wt.-% of 2 claim 10 ,5-dichlorophenol.15. The process of claim 10 , wherein the crystalline fraction (C) obtained in step (ii) comprises 80 to 99.9 wt.-% of 2 claim 10 ,5-dichlorophenol.16. The process of claim 10 , wherein the distillation step (i) is carried out in a distillation column at a pressure of 5 kPa to 25 kPa claim 10 , and a bottom temperature of 60° C. to 230° C.17. The process of claim 10 , wherein the crystallization step (ii) is carried out using crystallization from a melt or a solution claim 10 , such as layer melt crystallization or suspension melt crystallization.18. The process of claim 17 , wherein the step of suspension ...

Process for Providing Dihalogen Substituted Salicylic Acid Derivatives

The present invention relates to a process for providing dihalogen substituted salicylic acid derivatives of formula (II): 114-. (canceled)16. The process of claim 15 , wherein the transition metal catalyst is a catalyst comprising Pd(II) claim 15 , Ru(II) claim 15 , Rh(II) claim 15 , Cu(II) claim 15 , or Fe(II).17. The process of claim 15 , wherein Ris —CN claim 15 , and Ris —(C-C)alkyl claim 15 , and the step of reacting the compound of formula (I) is carried out in the further presence of an oxidant and an alcohol of formula HOR.18. The process of claim 17 , wherein the oxidant is selected from the group consisting of KSO claim 17 , NaSO claim 17 , Oand a peroxyacetic acid ester.19. The process of claim 18 , wherein the oxidant is NaSO.21. The process of claim 15 , wherein Ris —COOH claim 15 , and Ris hydrogen claim 15 , and the step of reacting the compound of formula (I) is carried out is the further presence of molecular oxygen.23. The process of claim 15 , wherein Ris —CORand Ris selected from the group consisting of —O(C-C)alkyl claim 15 , —(C-C)alkyl and —(C-C)aryl claim 15 , and Ris hydrogen claim 15 , and the step of reacting the compound of formula (I) is carried out in the further presence of an oxidant and a carboxylic acid and a corresponding anhydride.24. The process of claim 23 , wherein the oxidant is KSOor PhI(OAc)and/or the carboxylic acid is trifluoroacetic acid (TFA) and the corresponding acid anhydride is trifluoroacetic anhydride (TFAA) claim 23 , wherein the ratio of TFA to TFAA is 5:1 to 13:1.27. The process of claim 15 , wherein(a) Hal is selected from the group consisting of —Cl and —Br; and/or{'sup': '2', '(b) Ris selected from the group consisting of hydrogen, methyl and ethyl; and/or'}{'sub': '2', '(c) a Pd(II) catalyst, Pd(OAc)is used as the transition metal catalyst in the step of reacting a compound of formula (I) to obtain a compound of formula (II).'} The present invention relates to a process for providing dihalogen substituted ...

GRAPHICAL USER INTERFACE TO ADAPT VIRTUALIZER SWEET SPOT

Systems and methods discussed herein can provide three-dimensional audio virtualization with sweet spot adaptation. In an example, an audio processor circuit can be used to update audio signals for sweet spot adaptation based on user information input to a graphical user interface information about a listener position in a listening environment. 1. A system for adjusting one or more received audio signals based on user input indicating a sweet spot location relative to a speaker , the system comprising:a graphic display circuit to cause display of a sweet spot graphic at a display screen location in relation to a display screen location of a graphic representing a speaker location, based upon user input selecting the sweet spot graphic display screen location;a 3D sweet spot position determination circuit to determine a sweet spot location in relation to the speaker location, based at least in part upon the speaker location and the user-selected sweet spot graphic display screen location in relation to the display screen location of the graphic representing the speaker location; andan audio processor circuit configured to generate one or more adjusted audio signals based at least in part upon the one or more received audio signals and an indication of the determined sweet spot location in relation to the speaker location.2. The system ofwherein the graphic display circuit further to cause display at the display screen of a distance graphic indicating a user selected distance; andwherein the 3D sweet spot position determination circuit to determine the sweet spot location in relation to the speaker location, based at least in part upon both the physical speaker location and the user-selected sweet spot graphic display screen location in relation to the display screen location of the graphic representing a speaker location.3. The system of claim 1 ,wherein the graphic display circuit further to cause display at the display screen of a graphic representing a range of ...

Process for manufacturing substituted 5-methoxymethylpyridine-2,3-dicarboxylic acid derivatives

Process for manufacturing substituted 5-methoxymethylpyridine-2,3-dicarboxylic acid derivatives Abstract A process for manufacturing a 2,3-disubstituted-5-methoxymethylpyridine of formula (I), where Z is H or halogen; Z 1 is H, halogen, CN or NO 2 ; Y 2 is OM, and M is an alkali metal or an alkaline earth metal, comprises the step of: (i) reacting a compound of formula (II) where Q is a tertiary aliphatic or cyclic, saturated, partially unsaturated or aromatic amine; Z is H or halogen; Z 1 is H, halogen, CN or NO 2 ; Y 1 and Y 2 are each independently OR 1 , NR 1 R 2 , or when taken together Y 1 Y 2 is -O-, -S- or -NR 3 -; R 1 and R 2 are each independently H, C 1 -C 4 alkyl optionally substituted with C 1 -C 4 alkoxy or phenyl optionally substituted with one to three C 1 -C 4 alkyl groups, C 1 -C 4 alkoxy groups or halogen atoms, or phenyl optionally substituted with one to three C 1 -C 4 alkyl groups, C 1 -C 4 alkoxy groups or halogen atoms; R 3 is H or C 1 -C 4 alkyl, in a methanol/H 2 O mixture, comprising at least 20% by weight H 2 O (based on the sum of water and bromide (II)), with a base comprising MOCH 3 and/or MOH, where M is alkali metal or alkaline earth metal, under pressure in a closed vessel at a temperature of from 75 to 110°C. Compounds of formula (I) are useful intermediates in the synthesis of herbicidal imidazolinones, like imazamox.

process for making a compound.

Process for manufacturing 5-methoxymethylpyridine-2,3-dicarboxylic acid derivatives

An improved process for manufacturing a compound of formula (I), comprising steps (ii) and (iii): (ii) reacting a mixture of compounds of formulae (III.1), (III.2) and (III.3), with phosphorous acid (HPO(OH) 2 ) or a phosphite selected from dimethyl phosphite and diethyl phosphite, and trimethylamine in a solvent at a temperature range of 0°C to 100°C, to obtain a compound of formula (II); and (iii) reacting the compound of formula (II) in methanol, toluene or a methanol/toluene mixture with a base selected from MOCH 3 and MOH (if the solvent is methanol), where M is as defined in formula (I), to obtain the compound of formula (I).

TABIQUE FOR CONSTRUCTION

Aminophenyl ketone derivatives and a method for the preparation thereof

The present invention provides o-aminophenyl ketone derivatives which are intermediates useful in the manufacture of herbicidal sulfamoyl urea compounds, including the crop selective herbicide 1-{[o--(cyclopropylcarbonyl) phenyl]-sulfamoyl}-3-(4,6-dimethoxy--2-pyrimidinyl)urea. Also provided is a method for the preparation of said intermediates.

process for the manufacture of a compound, compound, and, use of a compound

PROCESSO PARA A FABRICAÇÃO DE UM COMPOSTO, COMPOSTO, E, USO DE UM COMPOSTO. Um processo para a fabricação de um éster do ácido 5-formil-piridina-2,3- dicarboxílico (I), em que, Z é hidrogênio ou halogênio; Z' é hidrogênio, halogênio, ciano ou nitro; e R', R' são independentemente alquila C1-10, compreendendo os estágios de: (i) reagir um composto da fónnula (II), em que os símbolos são como na fórmula (I), com um agente de nitrosação (III), R'-O-N = O (III) em que R' é alquila Cl-C8, na presença de um alcoolato de metal alcalino ou de metal alcalino terroso, em um solvente aprótico polar, em uma temperatura de a partir de -45 a 40°C, para obter um composto oxima (IV), em que Z, Z', R' e R' são como na fómula (I), e (ii) reagir o composto oxima (IV) com um aldeído C1-C10 alifático, na presença de um ácido, em uma temperatura em uma faixa de a partir de 0 a 100°C. Os compostos da fónnula (I) são úteis como intermediários na síntese de imidazolinonas herbicidas, tais que imazamox. PROCESS FOR THE MANUFACTURE OF A COMPOUND, COMPOUND, AND, USE OF A COMPOUND. A process for the manufacture of an ester of 5-formyl-pyridine-2,3-dicarboxylic acid (I), on what, Z is hydrogen or halogen; Z 'is hydrogen, halogen, cyan or nitro; and R ', R' are independently C1-10 alkyl, comprising the stages of: (i) reacting a compound of formula (II), where the symbols are as in formula (I), with a nitrating agent (III), R'-O-N = O (III) where R 'is Cl-C8 alkyl, in the presence of an alkali metal or alkaline earth metal alcoholate, in a polar aprotic solvent, at a temperature from -45 to 40 ° C, to obtain an oxime (IV) compound, where Z, Z ', R' and R 'are as in formula (I), and (ii) reacting the oxime compound (IV) with an aliphatic C1-C10 aldehyde, in the presence of an acid, at a temperature in the range from 0 to 100 ° C. The compounds of formula (I) are useful as intermediates in the synthesis of herbicidal imidazolinones, ...

System and method for generating profile change using cephalometric monitoring data

Method and Apparatus for Dialogue Understandability Assessment

A method comprises: obtaining a mixed soundtrack that includes dialogue mixed with non-dialogue sound; converting the mixed soundtrack to comparison text; obtaining reference text for the dialogue as a reference for intelligibility of the dialogue; determining a measure of intelligibility of the dialogue of the mixed soundtrack to a listener based on a comparison of the comparison text against the reference text; and reporting the measure of intelligibility of the dialogue.

Process for purifying 2,5-dichlorophenol

A process for purifying 2,5-dichlorophenol, the process comprising the steps of distillation and subsequent crystallization.

Aminophenyl ketone derivatives and a method for the preparation thereof

4-Hydroxy-2'-nitrobutyrophenone and tetrahydro-2-(O-nitrophenyl)-2-furanol useful as intermediates in the preparation of a crop-seletive herbicide

SELECTIVE HYDROLYSIS AND ALCOHOLYSIS OF CHLORED BENZENES

Aminophenyl ketone derivatives, method for the preparation and use thereof

Az ő-aminő-fenil-kető-származékők (I) általánős képletében R jelentésealkil- vagy adőtt esetben szűbsztitűált fenilcsőpőrt, R1 jelentésehidrőgénatőm, cianő-, nitrő-, halőgén-, főrmil-, vagy adőtt esetbenszűbsztitűált alkil-, alkőxi-, alkil-tiő-, alkil-szűlfinil-, alkil-szűlfőnil-, alkil-karbőnil-, alkőxi-karbőnil-, dialkil-aminő-,dialkil-aminő-karbőnil-, dialkil-aminő-szűlfőnil-csőpőrt vagy egyheterőciklűsős csőpőrt, X jelentése -(CH2)3-Y, ciklőprőpil- vagytetrahidrő-2-őxő-3-fűrőil-csőpőrt és Y jelentés klór- vagy brómatőm,vagy hidrőxicsőpőrt. Az (I) általánős képletű vegyületeket kiindűlásianyagként alkalmazzák herbicid hatású szűlfamőil-karbamid-vegyületekelőállítsánál. ŕ In the general formula (I) of the amine phenyl-phenyl derivative (I), R is an alkyl or an optionally substituted phenyl group, R1 is hydrogen, a cyano, a nitro, a halo, a major alkyl or an optionally substituted alkyl, alkyloxy, alkyl, and the like. tertiary, alkylsulfinyl, alkylphenyl, alkylcarbonyl, alkyloxycarbonyl, dialkylamine, dialkylamine carbonyl, dialkylamine filtrate, or single-ring cyclic cores, X is - ( CH2) 3-Y, cyclic pellet-tetrahydrofuran-2-yl-3-sawdust, and Y is chlorine or bromine or hydrofluoric acid. The compounds of the general formula (I) are used as starting materials for the preparation of herbicidal filtrate phylamyl urea compounds. ŕ

Method for the preparation of 4-halo-2'-nitrobutyrophenone

Process for the preparation of 4-halo-2'nitrobutyrophenon

Process for the manufacture of 2-alkoxymethylacrolein

Herbicide intermediate o-nitrophenyl cyclopropyl ketone and a method for the preparation thereof

There is provided o-nitrophenyl cyclopropyl ketone, a key intermediate in the manufacture of the crop-selective, herbicidal agent 1-{[o-(cyclopropylcarbonyl)phenyl]sulfamoyl}-3-(4,6-dimethoxy-2-pyrimidinyl)urea and a method for the preparation of said ketone from dihydro-3-acetyl-2(3H)-furanone and o-nitrobenzoyl halide.

Process for producing 2-aza-bicyclo/2.2.1/hept-5-en-2-yl-acetic acid derivatives

Method of preparation of 2-alkoxymethylacrolein

There is provided a process for the manufacture of 2-alkoxymethylacrolein compounds via the reaction of an appropriate alcohol and acrolein in the presence of an acid and a trisubstituted amine to form an intermediate and the subsequent reaction of the intermediate with formaldehyde in the presence of an acid and a disubstituted amine. There is also provided a process for the manufacture of 3-alkoxymethylquinolines from 2-alkoxymethylacrolein.

Compound process for the preparation of a 4-halo-2-nitro-butyro-phenene compound and process for the preparation of 4-hydroxy-2'-nitro-butyrophenone or tetrahydro-2- (a-nitro-phenyl) -2 -furanol or mixtures of them

Aminophenyl derivatives and process for their preparation

Method for the preparation of 4-halo-2'-nitrobutyrophenone

The present invention provides a method for the preparation of a 4-halo-2'-nitrobutyrophenone compound having the structural formula I which comprises reacting a 2-nitrobenzoyl halide compound having the structural formula wherein X and R are as described above with at least one molar equivalent of the magnesium enolate of acetyl-butyrolactone in the presence of a solvent at an elevated temperature and optionally concentrating the resultant reaction mixture by distillation of the solvent. The formula I compound is an important intermediate in the manufacture of a sulfamoyl urea herbicidal agent.

System and method for generating profile change using cephalometric monitoring data

A method for generating an animated morph between a first image and a second image is provided. The method may include: (i) reading a first set of cephalometric landmark points associated with the first image; (ii) reading a second set of cephalometric landmark points associated with the second image; (iii) defining a first set of line segments by defining a line segment between each of the first set of cephalometric landmarks; (iv)defining a second set of line segments by defining a line segment between each of the second set of cephalometric landmarks such that each line segment of the second set of line segments corresponds to a corresponding line segment of the first set of line segments; and (v) generating an animation progressively warping the first image to the second image based at least on the first set of line segments and the second set of line segments.

2-azabicyclo(2.2.1)hept-5-ene-2-acetic acid, derivatives thereof and related compounds, process for the preparation of said compounds and the use of said compounds for the manufacture of n-phosphonomethylglycine

Process for the manufacture of 2-alkoxymethylacrolein

There is provided a process for the manufacture of 2-alkoxymethylacrolein compounds via the reaction of an appropriate alcohol and acrolein in the presence of an acid and a trisubstituted amine to form an intermediate and the subsequent reaction of the intermediate with formaldehyde in the presence of an acid and a disubstituted mine. There is also provided a process for the manufacture of 3-alkoxymethyl-quinolines from 2-alkoxymethylacrolein.

Herbicide intermediate o-nitrophenyl cyclopropyl ketone and a method for the preparation thereof

4-HYDROXY-2-NITROBUTYROPHENONE AND TETRAHYDRO-2- (O-NITROFENIL) -2-FURANOL AND METHODS FOR ITS PREPARATION.

Se proveen 4-hidroxi-2'-nitrobutirofenona y tetrahidro-2-(º-nitrofenil)-2-furanol y mezclas del mismo, que son importantes intermediarios para la preparación del agente herbicida selectivo de cultivos 1-{[º-(ciclopropilcarbonil)fenil]sulfamil}-3-(4,6 dimetoxi-2-pirimidinil)urea. También se provee un método para la preparación de 4-halo-2'-nitrobutirofenona, que es útil como intermediario para la preparación de 1-{[º-(ciclopropilcarbonil)fenil]sulfamil}-3-(4,6- dimetoxi-2-pirimidinil)urea.

Aminophenyl ketone derivatives and a method for the preparation thereof

o-Nitrophenyl cyclopropyl ketone, herbicidal intermediate and process for its preparation

4-hydroxy-2'-nitrobutyrophenone and tetrahydro-2-(o-nitrophenyl)-2-furanol useful as intermediates in the preparation of a crop-selective herbicide

There are provided 4-Hydroxy-2'-nitrobutyro-phenone and tetrahydro-2-(o-nitrophenyl)-2-furanol and mixtures thereof, important intermediates in the preparation of the crop-selective herbicidal agent 1-{[o-(cyclopropylcarbonyl)phenyl]sulfamoyl}-3-(4,6-di-methoxy-2-pyrimidinyl)urea. Also provided is a method for the preparation of 4-halo-2'-nitrobutyrophenone, useful as an intermediate in the preparation of 1-{[o-(cyclopropylcarbonyl)phenyl]sulfamoyl}-3-(4,6-dimethoxy-2-pyrimidinyl)urea.

Aminophenylketone derivatives and method for their preparation

The invention relates to derivatives of o-aminophenylketone which are intermediate compounds required for the preparation of herbicide sulphamoylcarbamides, including the selective herbicide concerning agricuktural crops 1-[/o-(cyclopropylcarbonyl)phenyl/-sulphamoyl]-3-(4,6-dimethoxy-2- pyrimidinyl)urea, as well to a method for their preparation. 10 claims

The herbicide intermediate o-nitrophenyl-cyclopropyl ketone and process for its preparation

Process for preparing o-aminophenylcyclopropyl ketone

In the present invention there is disclosed a process for preparing o-aminophenylcyclopropylketone. The proposed process is characterized in that dihydro-3-acetyl-2(3H)-furanone is brought into reaction with 0.5 to 1.0 M equivalent of magnesium alkoxide having 1 to 4 carbon atoms at a temperature in the range of 0 to 25 degC. The obtained intermediate is then brought into reaction with at least one molar equivalent of o-nitrobenzoylhalide in the presence of a solvent and at a temperature in the range of 15 to 35 degC. The obtained second intermediate is then heated in the presence of water, the formed dihydro-3-(o-nitrobenzoyl)-2(3H)-furanone is then brought into reaction hydrogen halide and the obtained 4-halogen-2ˆ-nitrobutyrophenone is recycled in the presence of a base. The obtained o-nitrophenyl cyclopropylketone is subsequently hydrogenated in the presence of a catalyst under formation of a target product. O-aminophenylcyclopropylketone, being an intermediate for the preparation of a herbicidally active and with respect to plants selective agent, 1-[[o-(cyclopropylcarbonyl)phenyl]sulfamoyl]-3-(4,6-dimethoxy-2-pyrimidinyl)-urea.

Aminophenyl ketone derivatives and preparation method thereof

The present invention provides o-aminophenyl ketone derivatives which are intermediates useful in the manufacture of herbicidal sulfamoyl urea compounds, including the crop selective herbicide 1-äÄo-(cyclopropylcarbonyl)phenylÜ-sulfamoylü-3-(4,6-dimethoxy-2-pyrim idinyl)urea. Also provided is a method for the preparation of said intermediates.

Nitrobenzene derivative and processes for preparing thereof

Řešení se týká 4-hydroxy-2'-nitrobutyrofenonu a tetrahydro-2(o-nitrofenyl)-2-furanolu, a jejich směsí. Tyto látka jsou důležitými meziprodukty při výrobě herbicidního činidla, selektivního vůči plodinám, 1-||(cyklopropylkarbonyl(fenyl| sulfamoyl|-3-4-(4,6-dimethoxy-2-pyrimidinyl) močoviny. Dále je popsán způsob výroby 4-halogen-2'-nitrobutyrofenonu, což je také užitečný meziprodukt při výrobě 1-||o-(cyklopropylkarbonyl)fenyl|-sulfamoyl|-3- -)4,6-dimethoxy-2-parimidinyl)močoviny.ŕ

Method of fabricating a through glass via on a suspended nanocrystalline diamond

2-AZABICYCLO (2,2,1) HEPT-5-EN-2-ACETIC ACID AND THEIR DERIVATIVES, THEIR PREPARATION AND APPLICATION

PROCESS FOR THE MANUFACTURE OF ACID DERIVATIVES 5-METOXIMETHYLPIRIDIN-2,3-DICARBOXYLIC REPLACED

Proceso para preparar 2,3.disustituida-5-metoximetilpiridinas de fórmula (I), en donde Z, Z1, Y y M tienen los significados de la descripción, que comprende: (i) reaccionar un compuesto de fórmula (II), en donde Q, Z, Z1, Y1 e Y2 tienen los significados de la descripción, en una mezcla de metanol/H2O, que comprende por lo menos 20% en peso de H2O (sobre la base de la suma de agua y bromuro (II)), con una base que comprende MOCH3 y/o MOH, donde M es metal alcalino o metal alcalinotérreo, bajo presión a una temperatura de 75 a 110ºC.

Process for manufacturing substituted 3-pyridylmethyl ammonium bromides.

Un proceso para fabricar bromuros 5,6-disustituido-3-piridilmetila monio (I), comprende los pasos de (i) hacer reaccionar un compuesto de la fórmula (II), para obtener un compuesto de piridina 3-bromometil-5,6-disustituido (III), (ii) hacer reaccionar el compuesto de bromo de la fórmula (III) con una base Q de amina terciaria en un solvente a un rango de temperatura de aproximadamente 0°C a 100°C.

2-azabicyclo¬2.2.1|hept-5-ene-2-acetic acid, derivatives thereof and related compounds, process for the preparation of said compounds and the use of said compounds for the manufacture of n-phosphonomethylglycine

A compound having the structure V wherein R3, R4, R5, R6, R7 and R8 are each independently hydrogen, C1-C4 alkyl, C6H5 or NO2; Y is COOR, CON(R1)2, or CN wherein R and R1 are each independently hydrogen or C1-C4 alkyl with the proviso that when R3, R4, R5, R6, R7 and R8 are hydrogen, R is independently hydrogen or C2-C4 alkyl. These compounds are useful as intermediates in the preparation of N-phosphonomethylglycine, a known herbicide and plant growth regulator.

Process for preparing 4-halogen-2'-nitrobutyrophenone

The following are claimed: A) 4-hydroxy-2'-nitrobutyrophenone (I); B) tetrahydro-2-(o-nitrophenyl)-2-furanol (II): and C) prepn. of 4-halo-2'-nitrobutyrophenone of formula (III) comprising reacting a cpd. of formula (IV) with a 2-haloethanol cpd. of formula (V) in the presence of an aq. base and a phase transfer catalyst, opt. in the presence of an organic solvent to form (I) and/or (II), and further reacting (I) and/or (II) with a hydrogen halide to form (III). X' = halo; R = 1-4C alkyl X" = Cl or Br. The hydrogen halide is used as an excess amt. and is HCl or HBr. The solvent is water and/or an aromatic hydrocarbon such as toluene. The reaction temp. is 40-130 deg.C. One molar equiv. of the 2-haloethanol cpd. is used. The phase transfer catalyst is benzyltrimethylammonium hydroxide and the aq. base is NaOH. (I) and/or (II) can be prepd. by reacting dihydro-3-(o-nitrobenzoyl)-2(3H)-furanone with an aq. acid selected from sulphuric acid, phosphoric acid and acetic acid, opt. in the presence of an organic solvent.

Production of arylpyrrol compounds in the presence of dipea base

The invention relates to a process for the production of compounds of formula (I), comprising Step A of reacting compounds of formula (II) with 2,3-dihalopropionitrile or 2-haloacrylonitrile in the presence of DIPEA. It also relates to a process for the production of compounds of formula (III), comprising Step B of reacting compounds of formula (I) with Br2 in the presence of DIPEA. It also relates to a process C for the production of compounds of formula (IV), comprising Step C of reacting compounds of formula (III) with di(C1-C4-alkoxy)methane and either POCl3, or a mixture comprising POCl3 and DMF, in the presence of DIPEA. It also relates to the use of DIPEA as a base in the production of compounds of formula (I), compounds of formula (III) or compounds of formula (IV).

Process for manufacturing substituted 5-methoxymethylpyridine-2,3-dicarboxylic acid derivatives

Process for manufacturing substituted 5-methoxymethylpyridine-2,3-dicarboxylic acid derivatives Abstract A process for manufacturing a 2,3-disubstituted-5-methoxymethylpyridine of formula (I), where Z is H or halogen; Z

Improved process for recovering n,n-dimethylformamide (dmf) from an aqueous process stream

The invention relates to an improved process for recovering N,N-Dimethylformamide (DMF) from an aqueous process stream by extracting with substituted phenols and subsequent distillation.

Improved process for recovering n,n-dimethylformamide (dmf) from an aqueous process stream

The invention relates to an improved process for recovering N,N-Dimethylformamide (DMF) from an aqueous process stream by adjusting the pH, extracting with Chloroform and subsequent distillation/rectification.

Systems and methods for omnichannel artificial intelligence (AI) restaurant management

Systems, methods, and/or articles of manufacture that utilize omnichannel Artificial Intelligence (AI) restaurant management modeling to accurately compute and update order fulfillment times in an omnichannel ordering environment.

Method for producing 2-[4-(4-chlorophenoxy)-2-(trifluoromethyl)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol

The present invention relates to a method for producing 2-[4-(4-chlorophenoxy)-2- (trifluoromethyl)phenyl]-1-(1,2,4-triazol-1-yl)propan-2-ol in high purity and yield.

Process for producing 2,5-dihalophenolethers

The present invention relates to a process for providing a compound of formula (IV):wherein R 1 and R 2 are each independently C 1 -C 4 alkyl, and Hal is independently Cl or Br, the process comprising the steps of: (i) reacting a compound of formula (II) wherein R 1 and Hal is defined as above, to obtain a compound of formula (III) wherein R 1 and Hal is defined as above, and (ii) reacting the compound of formula (III) to obtain the compound of formula (IV).

Process for recovering saflufenacil from process streams

A process for increasing the yield of a process for the preparation of Compound (I), in which Compound (I) is obtained in solubilized form in an organic solvent phase, crystallized and separated from the mother liquor, comprising (I) STEP I) wherein the mother liquor is extracted with a basic buffer solution, adjusting the pH between 7 and 10 and extracting Compound (I) into the aqueous phase; and STEP II) wherein Compound (I) is back-extracted from the aqueous phase by decreasing the pH to below 6 in the presence of organic solvent.

O-nitrophenyl cyclopropyl keton, herbizides zwischenprodukt und verfahren zu seiner herstellung

Amino-fenil-keton-származékok, eljárás előállításukra és alkalmazásukra

Az ő-aminő-fenil-kető-származékők (I) általánős képletében R jelentésealkil- vagy adőtt esetben szűbsztitűált fenilcsőpőrt, R1 jelentésehidrőgénatőm, cianő-, nitrő-, halőgén-, főrmil-, vagy adőtt esetbenszűbsztitűált alkil-, alkőxi-, alkil-tiő-, alkil-szűlfinil-, alkil-szűlfőnil-, alkil-karbőnil-, alkőxi-karbőnil-, dialkil-aminő-,dialkil-aminő-karbőnil-, dialkil-aminő-szűlfőnil-csőpőrt vagy egyheterőciklűsős csőpőrt, X jelentése -(CH2)3-Y, ciklőprőpil- vagytetrahidrő-2-őxő-3-fűrőil-csőpőrt és Y jelentés klór- vagy brómatőm,vagy hidrőxicsőpőrt. Az (I) általánős képletű vegyületeket kiindűlásianyagként alkalmazzák herbicid hatású szűlfamőil-karbamid-vegyületekelőállítsánál. ŕ

Verfahren zur herstellung von 2- alkoxymethylakrolein und seine verwendung zur herstellung von 3-alkoxymethylchinolinen

Systems and methods for omnichannel artificial intelligence (ai) restaurant management

Systems, methods, and/or articles of manufacture that utilize omnichannel Artificial Intelligence (AI) restaurant management modeling to accurately compute and update order fulfillment times in an omnichannel ordering environment.

Systems and methods for omnichannel artificial intelligence (ai) restaurant management

Systems, methods, and/or articles of manufacture that utilize omnichannel Artificial Intelligence (AI) restaurant management modeling to accurately compute and update order fulfillment times in an omnichannel ordering environment.

소프트 압력 센서 및 이의 제조방법

소프트 압력 센서가 개시된다. 본 발명에 따른 소프트 압력 센서는, 전하 축적 특성을 갖는 기능성 고분자를 포함하는 변형부; 상기 변형부 내에 패터닝 되어 센서를 작동시키기 위한 구동 전압을 인가하는 작동 전극부; 상기 변형부 내에 패터닝 되는 접지 전극부; 및 상기 작동 전극부 및 상기 접지 전극 사이에 전기적으로 연결되어 상기 센서의 임피던스를 측정하기 위한 제어부;를 포함한다.

2-азабицикло (2,2,1)-хепт-5- ен-2-оцетна киселина и нейни производни, метод за получаване и приложението им

Изобретението се отнася до 2-азабицикло-[2,2,1]-хепт-5-ен-2-оцетна киселина и нейни производни, получаването и използването им за получаване на n-фосфонометилглицин. 9 претенции

2-[(1-cyanopropyl)carbamoyl]-5-chloromethyl nicotinic acids and the use thereof in manufacturing herbicidal imidazolinones

2-[(1-cyanopropyl)carbamoyl]-5-chloromethyl nicotinic acids of formula (I) where Z is hydrogen or halogen; Z 1 is hydrogen, halogen, cyano or nitro; R 1 is C 1 -C 4 alkyl; R 2 is C 1 -C 4 alkyl, C 3 -C 6 cycloalkyl or R 1 and R 2 , when taken together with the atom to which they are attached, represent a C 3 -C 6 cycloalkyl group optionally substituted with methyl, and R 3 is hydrogen or a cation preferably selected from the group consisting of alkali metals, alkaline earth metals, manganese, copper, iron, zinc, cobalt, lead, silver, nickel, ammonium and organic ammonium; are useful intermediates for the synthesis of herbicidal imidazolinones.

Un Metodo per l'Ottimale Auto-Calibrazione in un sistema di Risonanza Magnetica Nucleare basato su un algoritmo per la codifica robusta dello spostamento chimico (OSCAR)

Fremgangsmåde til oprensning af 2,5-dichlorphenol

Processos a, b, c para produção de compostos e uso de diisopropiletilamina

A presente invenção refere-se a um processo de produção de compostos da fórmula (I): , que compreende a Etapa A de reação de compostos da fórmula (II): com 2,3-di-halopropionitrila ou 2- haloacrilonitrila na presença de DIPEA. Ela também se refere a um processo de produção de compostos da fórmula (III): , que compreende a Etapa B de reação de compostos da fórmula (I) com Br2 na presença de DIPEA. Ela também se refere a um Processo C de produção de compostos da fórmula IV: , que compreende a Etapa C de reação de compostos da fórmula (III) com di(alcóxi C1-C4) metano e POCl3 ou uma mistura que compreende POCl3 e DMF, na presença de DIPEA. Ela também se refere ao uso de DIPEA como base na produção de compostos da Fórmula (I), compostos da Fórmula (III) ou compostos da Fórmula (IV).

System and method for transmitting digital multimedia data with analog broadcast data.

A method and system for the transmission of digital data (210) over existing analog radio frequencies (230) is presented, wherein the digital data may include audio data, visual data or audio-visual data for presentation either with analog broadcast data or at a selectable time. The digital data may be transmitted over a plurality of sub-channels that have varying degrees or reliability (250). A 'quality-of-service' process manages the transmission of digital data over various sub-channels based on the reliability of the sub-channel, the amount of digital data and the type of digital data to be transmitted. The digital data may further be encrypted and authenticated.

Verfahren zur herstellung von 4-halo- 2'nitrobutyrophenon

Aminophenyl-keton-derivate und eine methode für ihre herstellung

Systems and methods for omnichannel artificial intelligence (ai) restaurant management

Systems, methods, and/or articles of manufacture that utilize omnichannel Artificial Intelligence (AI) restaurant management modeling to accurately compute and update order fulfillment times in an omnichannel ordering environment.