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Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
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Применить Всего найдено 5933. Отображено 100.
05-01-2012 дата публикации

Process for producing alkylated aromatic compounds and process for producing phenols

Номер: US20120004471A1
Автор: Kenji Fujiwara, Masao Imai, Masayasu Ishibashi, Shinobu Aoki, Terunori Fujita, Tsuneyuki Ohkubo
Принадлежит: Mitsui Chemicals Inc

According to a process of the invention, a ketone, an aromatic compound and hydrogen as starting materials are reacted together in a single reaction step to produce an alkylaromatic compound in high yield. A process for producing phenols in the invention includes a step of performing the above alkylation process and does not increase the number of steps compared to the conventional cumene process. The process for producing alkylated aromatic compounds includes reacting an aromatic compound such as benzene, a ketone such as acetone and hydrogen in the presence of a solid acid substance, preferably a zeolite, and a silver-containing catalyst.

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Номер записи: 1
12-07-2012 дата публикации

Process For Producing Cyclohexylbenzene

Номер: US20120178969A1
Автор: Jane C. Cheng, Prasenjeet Ghosh, Tan-Jen Chen
Принадлежит: ExxonMobil Chemical Patents Inc

In a process for producing cyclohexylbenzene, benzene and hydrogen are contacted under hydroalkylation conditions with a catalyst system comprising a MCM-22 family molecular sieve and at least one hydrogenation metal. The conditions comprise a temperature of about 140° C. to about 175° C., a pressure of about 135 psig to about 175 psig (931 kPag to 1207 kPag), a hydrogen to benzene molar ratio of about 0.30 to about 0.65 and a weight hourly space velocity of benzene of about 0.26 to about 1.05 hr −1 .

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Номер записи: 2
14-02-2013 дата публикации

Propylene-based polymer, articles, and process for producing same

Номер: US20130041113A1
Автор: Linfeng Chen, William G. Sheard
Принадлежит: Linfeng Chen, William G. Sheard

Disclosed are propylene-based polymer compositions and processes for producing same. Polymerization with an improved catalyst composition provides a propylene-based polymer with improved stiffness.

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Номер записи: 3
07-03-2013 дата публикации

Therapeutic Compounds

Номер: US20130059919A1
Автор: Thomas E. Jenkins
Принадлежит: Individual

A (−)-stereoisomer of formula (I): [insert formula (I) wherein X is H or F; or a pharmaceutically acceptable salt or prodrug thereof, useful as an anesthetic.

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Номер записи: 4
11-04-2013 дата публикации

Cyclohexanone Dehydrogenation Catalyst and Process

Номер: US20130090499A1
Автор: Bakka Jihad M., Chen Tan-Jen, DeCaul Lorenzo C., Helton Terry E., JR. Edward A., Lemon, Miseo Sabato, Xu Teng
Принадлежит:

A catalyst composition comprising: (i) a support; (ii) a first component comprising at least one metal component selected from Group 1 and Group 2 of the Periodic Table of Elements; and (iii) a second component comprising at least one metal component selected from Groups 6 to 10 of the Periodic Table of Elements, wherein the catalyst composition exhibits an oxygen chemisorption of greater than 50%. 2. The process of claim 1 , wherein the inorganic support is at least one material selected from silica claim 1 , a silicate claim 1 , and an aluminosilicate.3. The process of claim 1 , wherein the inorganic support comprises silica.4. The process of claim 1 , wherein the second component comprises at least one metal component selected from platinum and palladium.5. The process of claim 1 , wherein the first component comprises a metal component comprising potassium.6. The process claim 1 , wherein the calcining (b) is conducted in an oxygen-containing atmosphere.7. The process of claim 1 , wherein the calcining (d) is conducted in an oxygen-containing atmosphere.8. The process of claim 1 , wherein the dehydrogenation conditions include a temperature of about 250° C. to about 500° C. claim 1 , a pressure of about 100 to about 3550 kPa claim 1 , a weight hourly space velocity of about 0.2 to 50 hr claim 1 , and a hydrogen to cyclohexanone-containing feed molar ratio of about 2 to about 20 claim 1 ,10. The process of claim 9 , wherein the inorganic support is selected from at least one material selected from silica claim 9 , a silicate claim 9 , and an aluminosilicate.11. The process of claim 9 , wherein the inorganic support comprises silica.12. The process of claim 9 , wherein the second component comprises at least one metal component selected from platinum and palladium.13. The process of claim 9 , wherein the first component comprises a metal component comprising potassium.14. The process of claim 9 , wherein the calcining (b) is conducted in an oxygen-containing ...

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Номер записи: 5
18-04-2013 дата публикации

Process for Preparation of Optically Active Compounds using Transfer Hydrogenation

Номер: US20130096337A1
Автор: Foulkes Michael, Kesselgruber Martin, Mathes Christian
Принадлежит: NOVARTIS AG

A catalytic process for the preparation of optically active compounds and their conversion thereafter to desired drug substances. In particular, the process relates to the preparation of (S)-3-(1-Dimethylamino-ethyl)-phenol using asymmetric catalytic reduction and transfer hydrogenation, thereby providing an improved route to forming drug substances such as rivastigimine and rivastigimine hydrogen tartrate. 139-. (canceled)42. The process of claim 41 , wherein the asymmetric catalytic reduction forms an enantiomeric excess of compound (III) to compound (IV) of from about 96%:4% or higher claim 41 , about 98%:2% or higher claim 41 , or about 99%:1% or higher.43. The process of claim 41 , wherein after a crystallization step the enantiomeric excess of compound (III) to compound (IV) is from about 97%:3% or higher claim 41 , about 98%:2% or higher claim 41 , about 99%:1% or higher claim 41 , or about >99.5%:about <0.5% claim 41 , or about >99.7%:about <0.03.%.44. The process of claim 41 , wherein n=1 in general formulas (I)-(IV).45. The process of claim 41 , wherein n=1 in general formulas (I)-(IV) and a hydroxyl group occurs at position 3 on the aromatic ring.46. The process of claim 40 , wherein Ris a Calkyl claim 40 , Calkenyl claim 40 , Calkynyl claim 40 , or Corganohalide.47. The process of claim 40 , wherein Ris selected from any of methyl claim 40 , ethyl claim 40 , propyl and butyl.49. The process of claim 40 , wherein the transfer hydrogenation is performed using a chiral transition metal based catalyst.50. The process of claim 40 , wherein the transfer hydrogenation is performed using a complexed transition metal based chiral catalyst containing multiple aryl claim 40 , mono- bi- claim 40 , or poly-dentate ligands.51. The process of claim 40 , wherein the transfer hydrogenation is performed using a Ru claim 40 , Rh or Ir based catalyst.52. The process of claim 40 , wherein the transfer hydrogenation is performed using a chiral (diphenylethylenediamine) based ...

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Номер записи: 6
09-05-2013 дата публикации

METHOD AND SYSTEM FOR PRODUCING GRAPHENE AND GRAPHENOL

Номер: US20130112925A1
Автор: Beall Gary W.
Принадлежит: NATIONAL NANOMATERIALS, INC.

This disclosure includes a process that unexpectedly can produce very inexpensive graphene and a new compound called graphenol in particulate or dispersions in solvents. The process can also produce graphene layers on metallic and nonmetallic substrates. Further, the graphenol and graphene can be utilized to form nanocomposites that yield property improvements exceeding anything reported previously. 1. A process for making graphenol , said process comprising the steps of:providing a carbonaceous material;extracting a humic acid solution from said carbonaceous material via a basic solution, said basic solution having a hydroxide concentration of at least approximately 0.005 moles per liter; and placing said humic acid solution in a pressure reactor;', 'adding a hydrogenation catalyst to said humic acid solution;', 'purging said pressure reactor with an inert gas;', 'charging said pressure reactor with hydrogen gas;', 'heating said humic acid solution; and', 'removing said hydrogenation catalyst from said humic acid solution,, 'chemically reducing at least one of a carbonyl group portion and a carboxylic acid group portion of said humic acid solution, said step of chemically reducing comprising the steps ofthereby producing a solution containing graphenol.2. The process of claim 1 , wherein said carbonaceous material comprises lignite or peat.3. The process of claim 1 , wherein said carbonaceous material comprises leonardite.4. The process of claim 3 , wherein said basic solution is chosen from the group consisting of sodium hydroxide claim 3 , potassium hydroxide claim 3 , and ammonium hydroxide.5. The process of claim 3 , wherein said basic solution comprises ammonium hydroxide claim 3 , and further comprising the step of removing said ammonium hydroxide by heating after said step of chemically reducing said at least one of a carbonyl group portion and a carboxylic acid group portion.6. The process of claim 1 , wherein said step of removing said hydrogenation ...

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Номер записи: 7
16-05-2013 дата публикации

Simultaneous Hydrolysis Refine Method Of Cellulose Biomass

Номер: US20130123547A1
Автор: Chungao Su, Hongping Ye, Meg M. Sun, Zuolin Zhu
Принадлежит: Individual

A method of refining cellulosic biomass, including synchronous hydrolyzation of at least 85 wt % organic polymers, based on the total weight of the cellulosic biomass, in the cellulosic biomass into small molecular organic compounds. The synchronous hydrolyzation is catalytic hydrolyzation for which the catalyst used is a substance represented by L-M-S-H or L-M=S, wherein “M” represents metal, carbon or silicon, “S” represents a heteroatom, “L” represents one or more ligands, and “H” represents hydrogen.

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Номер записи: 8
23-05-2013 дата публикации

Production of renewable aromatic compounds

Номер: US20130130345A1
Автор: David A. Sikkenga, Wendy Thai, Will SCHROEDER
Принадлежит: JNF BIOCHEMICALS LLC

The invention provides a process for producing a variety renewable aromatic compounds such as benzene, toluene, xylenes, and cumene, as well as compounds derived from these including, for example, aniline, benzoic acid, cresol, cyclohexane, cyclohexanone, phenol and bisphenol A, toluene di-isocyanate, isophthalic acid, phthalic anhydride, terephthalic acid and dimethyl terephthalate. The invention also provides for renewable forms of these aromatic compounds.

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Номер записи: 9
06-06-2013 дата публикации

METHOD AND SYSTEM FOR PRODUCING GRAPHENE AND FUNCTIONALIZED GRAPHENE

Номер: US20130140495A1
Автор: Beall Gary W.
Принадлежит: NATIONAL NANOMATERIALS, INC.

This disclosure includes a process that unexpectedly can produce very inexpensive graphene, functionalized graphenes, and a new compound called graphenol in particulate or dispersions in solvents. The process can also produce graphene layers on metallic and nonmetallic substrates. Further, the graphenol, functionalized graphenes, and graphene can be utilized to form nanocomposites that yield property improvements exceeding anything reported previously. 1. A process for making graphenol or functionalized graphenes , said processes comprising the steps of:providing a carbonaceous material;extracting a humic acid solution from said carbonaceous material via a basic solution, said basic solution having a hydroxide concentration of at least approximately 0.005 moles per liter; and placing said humic acid solution in a pressure reactor;', 'adding a hydrogenation catalyst to said humic acid solution;', 'purging said pressure reactor with an inert gas;', 'charging said pressure reactor with hydrogen gas;', 'heating said humic acid solution; and', 'removing said hydrogenation catalyst from said humic acid solution,, 'chemically reducing at least one of a carbonyl group portion and a carboxylic acid group portion of said humic acid solution, said step of chemically reducing comprising the steps ofthereby producing a solution containing graphenol.2. The process of claim 1 , wherein said carbonaceous material comprises lignite or peat.3. The process of claim 1 , wherein said carbonaceous material comprises leonardite.4. The process of claim 3 , wherein said basic solution is chosen from the group consisting of sodium hydroxide claim 3 , potassium hydroxide claim 3 , and ammonium hydroxide.5. The process of claim 3 , wherein said basic solution comprises ammonium hydroxide claim 3 , and further comprising the step of removing said ammonium hydroxide by heating after said step of chemically reducing said at least one of a carbonyl group portion and a carboxylic acid group portion ...

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Номер записи: 10
04-07-2013 дата публикации

"process for producing cycloalkylaromatic compounds"

Номер: US20130172514A1
Автор: Teng Xu, Wenyih F. Lai
Принадлежит: ExxonMobil Chemical Patents Inc

In a process for producing a cycloalkylaromatic compound, an aromatic compound, hydrogen and at least one diluent are supplied to a hydroalkylation reaction zone, such that the weight ratio of the diluent to the aromatic compound supplied to the hydroalkylation reaction zone is at least 1:100. The aromatic compound, hydrogen and the at least one diluent are then contacted under hydroalkylation conditions with a hydroalkylation catalyst in the hydroalkylation reaction zone to produce an effluent comprising a cycloalkylaromatic compound.

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Номер записи: 11
08-08-2013 дата публикации

"OXIDATION OF HYDROCARBONS"

Номер: US20130203984A1
Автор: Becker Christopher L., Benitez Franisco M., Dakka Jihad M., Mozeleski Edmund J.
Принадлежит:

In a process for oxidizing a hydrocarbon to a product comprising at least one of the corresponding hydroperoxide, alcohol, ketone, carboxylic acid and dicarboxylic acid, the hydrocarbon is contacted with an oxygen-containing compound in at least one oxidation zone in the presence of a catalyst comprising a cyclic imide having an imide group of formula (I): 2. The process of claim 1 , wherein the oxygen-containing compound is air that has been at least partially dehydrated.3. The process of claim 1 , wherein said hydrocarbon comprises an alkane or cycloalkane.4. The process of claim 1 , wherein said hydrocarbon comprises isobutane or cyclohexane.5. The process of claim 1 , wherein said hydrocarbon comprises cyclohexane claim 1 , the product comprises cyclohexanol and the process further comprises converting the cyclohexanol to adipic acid.6. The process of claim 1 , wherein said hydrocarbon comprises cyclohexane claim 1 , the product comprises cyclohexanone and the process further comprises converting the cyclohexanone to caprolactam.7. The process of claim 1 , wherein said hydrocarbon comprises iso-butane claim 1 , the product comprises tert-butyl hydroperoxide and the process further comprises using the tert-butyl hydroperoxide as an oxidation catalyst.9. The process of claim 8 , wherein said alkylaromatic compound of general formula (II) is selected from ethyl benzene claim 8 , cumene claim 8 , sec-butylbenzene claim 8 , sec-pentylbenzene claim 8 , p-methyl-sec-butylbenzene claim 8 , 1 claim 8 ,4-diphenylcyclohexane claim 8 , sec-hexylbenzene claim 8 , and cyclohexylbenzene.10. The process of claim 8 , and further comprising cleaving the hydroperoxide to produce phenol or a substituted phenol.13. The process of claim 1 , wherein said cyclic imide comprises N-hydroxyphthalimide.14. The process of claim 1 , wherein said oxygen-containing compound supplied to said oxidation zone has a water content of less than or equal to 0.3% by weight of the oxygen-containing ...

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Номер записи: 12
08-08-2013 дата публикации

"CYCLOHEXANONE COMPOSITIONS"

Номер: US20130204045A1
Автор: Benitez Francisco Manuel, Kuechler Keith Holroyd
Принадлежит:

Described herein are compositions having (a) at least 99 wt % cyclohexanone; and (b) 0.1 wppm to 1000 wppm of at least one of cyclohexanedione and hydroxycyclohexanone. The wt % and wppm are based upon the total weight of the composition. The compositions may further comprise 0.1 wppm to 1000 wppm of cyclohexanol. 1. A composition comprising:(a) at least 99 wt % cyclohexanone; and(b) 0.1 wppm to 1000 wppm of at least one of cyclohexanedione and hydroxycyclohexanone, wherein the wt % and wppm are based upon the total weight of the composition.2. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 100 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.3. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 10 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.4. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 1 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.5. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 100 wppm of each one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.6. The composition of claim 1 , wherein the composition comprises 1 wppm to 100 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.7. The composition of claim 1 , wherein the composition comprises 2 wppm to 100 wppm of at least one of cyclohexanedione and hydroxycyclohexanone claim 1 , based upon the total weight of the composition.8. The composition of claim 1 , wherein the composition comprises 0.1 wppm to 1000 wppm of cyclohexanol claim 1 , based upon the total weight of the composition.9. The composition of claim 1 , wherein the composition comprises 0.1 ...

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Номер записи: 13
08-08-2013 дата публикации

Dehydrogenation Process

Номер: US20130204048A1
Автор: Dakka Jihad M., DeCaul Lorenzo C.
Принадлежит: ExxonMobil Chemical Patents Inc.

In a process for the dehydrogenation of at least one dehydrogenatable hydrocarbon, at least one dehydrogenatable hydrocarbon selected from an oxygen-containing six-membered carbon ring compound is supplied to a first dehydrogenation reaction zone together with at least one stabilizing compound selected from a non-oxygen-containing six membered carbon ring compound to the first dehydrogenation reaction zone, such that the weight ratio of the stabilizing compound to the dehydrogenatable hydrocarbon supplied to the first dehydrogenation reaction zone is in the range of from 1:200 to 200:1. The dehydrogenation feed stream and the at least one stabilizing compound are contacted with a first dehydrogenation catalyst in the first dehydrogenation reaction zone under dehydrogenation conditions to convert at least a portion of the dehydrogenatable hydrocarbon into an unsaturated six-membered carbon ring compound and hydrogen. 1. A process for the dehydrogenation of at least one dehydrogenatable hydrocarbon , the process comprising:(a) supplying a dehydrogenation feed stream comprising at least one dehydrogenatable hydrocarbon to a first dehydrogenation reaction zone wherein the at least one dehydrogenatable hydrocarbon is an oxygen-containing six-membered carbon ring compound;(b) supplying at least one stabilizing compound to the first dehydrogenation reaction zone, such that the weight ratio of the stabilizing compound to the dehydrogenatable hydrocarbon supplied to the first dehydrogenation reaction zone is in the range of from 1:200 to 200:1 wherein the stabilizing compound is a non-oxygen-containing six membered carbon ring compound; and(c) contacting the at least one dehydrogenatable hydrocarbon and the at least one stabilizing compound with a first dehydrogenation catalyst in the first dehydrogenation reaction zone under dehydrogenation conditions to convert at least a portion of the dehydrogenatable hydrocarbon into an unsaturated six-membered carbon ring compound and ...

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Номер записи: 14
15-08-2013 дата публикации

Oxidation of Alkylbenzenes

Номер: US20130211036A1
Автор: Becker Christopher L., Dakka Jihad M., Mozeleski Edmund J., Smith Charles Morris, Zushma Stephen
Принадлежит: ExxonMobil Chemical Company - Law Technology

A process for oxidizing a composition comprising contacting an alkylbenzene of the general formula (I): 2. The process of claim 1 , and further comprising:(c) cleaving at least a portion of the alkylbenzene hydroperoxide produced by the contacting step (b) to produce phenol and cyclohexanone.3. The process of claim 2 , wherein at least a portion of the phenol present in the feed in the composition is provided from a recycle stream from the contacting step (b) and/or the cleaving step (c).4. The process of claim 1 , wherein the composition comprises from about 0.1 wt % to about 1 wt % of phenol based upon total weight of the composition.5. The process of claim 1 , wherein the composition comprises from about 0.15 wt % to about 0.5 wt % of phenol based upon total weight of the composition.6. The process of claim 1 , wherein the alkylbenzene is selected from cumene claim 1 , sec-butylbenzene claim 1 , cyclohexylbenzene and mixtures thereof.8. The process of claim 1 , wherein the cyclic imide comprises N-hydroxyphthalimide.9. The process of claim 1 , wherein the catalyst containing a cyclic imide having the general formula (II) is effective to remove at least a portion of the phenol.10. The process of claim 1 , wherein the cyclic imide is present in an amount of between 0.05 wt % and 5 wt % of the composition.11. The process of claim 1 , wherein the contacting step (b) is conducted at a temperature of between 90° C. and 150° C.12. The process of claim 1 , wherein the contacting step (b) is conducted at a temperature of between 105° C. and 120° C.13. The process of claim 1 , wherein the contacting step (b) is conducted at a pressure between 15 kPa and 500 kPa.14. (canceled)15. The process of claim 2 , wherein at least a portion of the phenol produced in the cleaving step (c) is converted to one or more of a phenolic resin claim 2 , bisphenol A claim 2 , ε-caprolactam claim 2 , an adipic acid claim 2 , or a plasticizer.16. The process of claim 2 , wherein at least a ...

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Номер записи: 15
15-08-2013 дата публикации

Process for the preparation of hydroquinones

Номер: US20130211149A1
Автор: Kadam Shahuraj Hanamantrao, Paknikar Shashikumar
Принадлежит: Merck Patent GmBH

The invention relates to a process for the preparation of a hydroquinone compound of formula (I)

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Номер записи: 16
22-08-2013 дата публикации

"PROCESSES FOR PRODUCING PHENOL"

Номер: US20130217921A1
Автор: Benitez Francisco M., Kuechler Keith H.
Принадлежит: ExxonMobil Chemical Patents Inc.

In a process for producing phenol and cyclohexanone, a feed comprising cyclohexylbenzene is oxidized to produce an oxidation reaction product comprising cyclohexyl-1-phenyl-1-hydroperoxide. At least a portion of the oxidation reaction product is then cleaved to produce a cleavage reaction product comprising phenol, cyclohexanone, and at least one contaminant. At least a portion of the cleavage reaction product is contacted with an acidic material to convert at least a portion of the at least one contaminant to a converted contaminant and thereby produce a modified reaction product. 1. A process for producing phenol comprising:(a) oxidizing at least a portion of a feed comprising cyclohexylbenzene to produce an oxidation composition comprising cyclohexyl-1-phenyl-1-hydroperoxide;(b) cleaving at least a portion of the oxidation composition to produce a cleavage reaction mixture comprising phenol, cyclohexanone and at least one contaminant; and(c) contacting at least a portion of the cleavage reaction mixture with an acidic material to convert at least a portion of the contaminant to a converted contaminant, thereby producing a modified reaction mixture.2. The process of claim 1 , wherein the contaminant is one or more of an acyclic aliphatic hexanal claim 1 , an acyclic aliphatic hexanone claim 1 , a cyclohexenone claim 1 , a cyclohexyldione claim 1 , a hydroxycyclohexanone claim 1 , benzoic acid claim 1 , a benzoic ester claim 1 , a cyclohexenyl cyclohexanone claim 1 , a methylcyclopentenyl cyclohexanone claim 1 , 1-phenyl-6-hydroxyhexan-1-one claim 1 , 1-cyclohexyl-6-hydroxyhexan-1-one and a bicyclic twelve carbon hydroperoxide.3. The process of claim 1 , wherein the acidic material comprises at least one of a microporous acid material claim 1 , a cation exchange resin claim 1 , a Bronsted acid claim 1 , and sulfurous acid or acid salt.4. The process of claim 1 , wherein the acidic material is a solid acid catalyst.5. The process of claim 1 , wherein the acidic ...

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Номер записи: 17
22-08-2013 дата публикации

Processes for Producing Phenol

Номер: US20130217922A1
Автор: Becker Christopher L., Benitez Francisco M., Kuechler Keith H., Lattner James R., Wang Kun
Принадлежит:

Disclosed herein is a process for producing phenol. The process includes oxidizing at least a portion of a feed comprising cyclohexylbenzene to produce an oxidation composition comprising cyclohexyl-1-phenyl-1-hydroperoxide. The oxidation composition may then be cleaved in the presence of an acid catalyst to produce a cleavage reaction mixture comprising the acid catalyst, phenol and cyclohexanone. At least a portion of the cleavage reaction mixture may be neutralized with a basic material to form a treated cleavage reaction mixture. In various embodiments, the treated cleavage reaction mixture contains no greater than 50 wppm of the acid catalyst or no greater than 50 wppm of the basic material. 1. A process for producing phenol comprising:(a) oxidizing at least a portion of a feed comprising cyclohexylbenzene to produce an oxidation composition comprising cyclohexyl-1-phenyl-1-hydroperoxide;(b) cleaving at least a portion of the oxidation composition in the presence of an acid catalyst to produce a cleavage reaction mixture comprising the acid catalyst, phenol and cyclohexanone; and(c) neutralizing at least a portion of the cleavage reaction mixture with a basic material to form a treated cleavage reaction mixture, wherein the treated cleavage reaction mixture contains no greater than 50 weight-parts-per-million (wppm) of the acid catalyst or no greater than 50 wppm of the basic material.2. The process of claim 1 , wherein the oxidation composition comprises at least 65 wt % cyclohexylbenzene claim 1 , the wt % based upon the total weight of the oxidation composition.3. The process of claim 1 , wherein the oxidation composition further comprises one or more hydroperoxides selected from cyclohexyl-1-phenyl-2-hydroperoxide; cyclohexyl-1-phenyl-3-hydroperoxide; cyclohexyl-1-phenyl-4-hydroperoxide; cyclopentyl-1-methyl-2-phenyl-2-hydroperoxide; cyclopentyl-1-methyl-3-phenyl-3-hydroperoxide; cyclopentyl-1-methyl-1-phenyl-2-hydroperoxide; cyclopentyl-1-methyl-1-phenyl-3 ...

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Номер записи: 18
12-09-2013 дата публикации

Method for tiered production of biobased chemicals and biofuels from lignin

Номер: US20130232852A1
Автор: Benjamin M.T. Scott, John R. Peterson, Vladimir Romakh
Принадлежит: Thesis Chemistry LLC

The present invention is directed generally to a method of production of value-added, biobased chemicals from lignin sources, including waste lignin. A method of using a depolymerization of lignin to create a tiered production of biobased aromatic chemicals and biofuels is also described herein. The method described herein may also allow for the selective production of the biobased aromatic chemicals and biofuels. Additionally, a reduction of waste products may also be provided from the present method.

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Номер записи: 19
10-10-2013 дата публикации

PROCESS FOR THE PREPARATION OF BENZYLBENZENE SGLT2 INHIBITORS

Номер: US20130267694A1
Автор: Lv Binhua, Roberge Jacques Y., Seed Brian, Xu Baihua, XU Ge
Принадлежит: Theracos, Inc.

Provided are methods of making compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT. The invention also provides synthetic intermediates useful for preparing such compounds. 3. The method of claim 1 , wherein{'sup': '2', 'Ris H;'}{'sup': '3', 'sub': 1', '6', '1', '3', '1', '3', '1', '3', '3', '6', '3', '6', '1', '3, 'Ris selected from the group consisting of C-Calkyl, C-Calkoxy, (C-Calkoxy)C-Calkoxy, C-Ccycloalkyl, and (C-Ccycloalkoxy)C-Calkoxy; and'}{'sup': '4', 'sub': 1', '3, 'Ris selected from the group consisting of H, OH and C-Calkoxy.'}4. The method of claim 1 , wherein Ris selected from the group consisting of C-Calkoxy claim 1 , C-Ccycloalkyl claim 1 , and (C-Ccycloalkoxy)C-Calkoxy.5. The method of claim 1 , wherein Ris selected from the group consisting of ethoxy claim 1 , cyclopropyl and 2-cyclopropoxyethoxy.6. The method of claim 1 , wherein Ris OH.7. The method of claim 1 , wherein{'sup': '2', 'Ris H;'}{'sup': '3', 'Ris selected from the group consisting of ethoxy, cyclopropyl and 2-cyclopropoxyethoxy; and'}{'sup': '4', 'Ris OH.'}8. The method of claim 1 , wherein the ratio of the alkyl-magnesium complex in step (a) to the compound of Formula II is from about 0.95 up to 1.0 (mol/mol).9. The method of claim 1 , wherein the first reaction mixture further comprises an accelerating agent selected from the group consisting of LiCl claim 1 , ZnCl claim 1 , diisobutylaluminum hydride claim 1 , sodium bis(2-methoxyethoxy)aluminum hydride claim 1 , tri-methylsilyl chloride claim 1 , and 2 claim 1 ,2′-oxybis(N claim 1 ,N-dimethylethanamine).10. The method of claim 9 , wherein the first reaction mixture further comprises LiCl.11. The method of claim 9 , wherein the ratio of the accelerating agent to the alkyl-magnesium complex is about 1.0 (mol/mol).12. The method of claim 1 , wherein the first reaction mixture is at a temperature of from about −60 to about −50° C.13. The method of claim 1 , wherein the second reaction mixture ...

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Номер записи: 20
17-10-2013 дата публикации

Oxidation of Alkylaromatic Compounds

Номер: US20130274524A1
Автор: Dakka Jihad M., Stanat Jon E.R., Zushma Stephen
Принадлежит:

In a process for oxidizing an alkylaromatic compound to the corresponding hydroperoxide, a feed comprising an alkylaromatic compound is contacted with an oxygen-containing gas in the presence of a catalyst comprising a cyclic imide. The contacting is conducted at a temperature of about 90° C. to about 150° C., with the cyclic imide being present in an amount between about 0.05 wt % and about 5 wt % of the alkylaromatic compound in the feed and the catalyst being substantially free of alkali metal compounds. The contacting oxidizes at least part of the alkylaromatic compound in said feed to the corresponding hydroperoxide. 3. The process of claim 1 , wherein said cyclic imide comprises N-hydroxyphthalimide.4. The process of claim 1 , wherein said contacting is conducted at a temperature of between about 125° C. and about 140° C. and a pressure of about 15 kPa to about 150 kPa.5. The process of claim 1 , wherein said cyclic imide is present in an amount between about 0.1 wt % and about 1 wt % of the alkylaromatic in said feed during said contacting.6. The process of claim 1 , wherein said cyclic imide is present in an amount between about 0.05 wt % and about 0.5 wt % of the alkylaromatic in said feed during said contacting.7. The process of claim 1 , wherein said contacting converts at least 4 wt % per hour conversion of said alkylaromatic compound with a selectivity to the corresponding alkylaromatic hydroperoxide of at least 90 wt %.8. The process of claim 1 , wherein said alkylaromatic compound is cyclohexylbenzene.9. The process of claim 1 , further comprising the step of:cleaving the alkylaromatic hydroperoxide to produce phenol and the corresponding ketone.10. The process of claim 9 , wherein the cleaving is conducted in the presence of a catalyst.11. The process of claim 9 , wherein the cleaving is conducted in the presence of a homogeneous catalyst.12. The process of claim 11 , wherein said homogeneous catalyst comprises at least one of sulfuric acid claim 11 ...

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Номер записи: 21
24-10-2013 дата публикации

Method for Cultivation of Monarda Fistulosa for Production of Thymoquinone

Номер: US20130281740A1
Автор: William G. Rohlfsen
Принадлежит: PRAIRIE PHARMS LLC

A method for cultivating Monarda fistulosa for production of thymoquinone includes planting seeds at rates between about 2.5 and about 5 pounds per acre, preferably about 4 pounds per acre. The heavy rate of planting produces plants bearing oil without weed contamination and reduces herbicide use due to production of natural herbicides by the monarda plants. Seeding and mowing the first season, and harvesting in seasons thereafter reduce costs. The method results in increased production of essential oils including thymoquinone and thymohydroquinone at levels up to about 5% of recovered oils, and which may be distilled from the plant.

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Номер записи: 22
14-11-2013 дата публикации

Method of producing biphenolic compound, novel biphenyl compound and synthesis method thereof, and pharmaceutical composition for treating parkinson's disease

Номер: US20130303788A1
Автор: Chinpiao Chen, Hwei-Hsien Chen, Ming-Huan Chan
Принадлежит: Tzu Chi Univ

A method of producing honokiol and analogues thereof, and novel intermediates prepared by virtue thereof are disclosed herein. A pharmaceutical composition for treating Parkinson's disease, which contains honokiol and/or the analogues thereof, is also disclosed herein.

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Номер записи: 23
28-11-2013 дата публикации

INTERMEDIATES FOR THE SYNTHESIS OF BENZINDENE PROSTAGLANDINS AND PREPARATIONS THEREOF

Номер: US20130317245A1
Автор: HSU Min-Kuan, HSU Ming-Kun, WEI Shih-Yi
Принадлежит: CHIROGATE INTERNATIONAL INC.

Novel processes for preparing optically active cyclopentanones 1 2. A process according to claim 1 , wherein M is phenyl or 4-phenylphenyl. This application is a divisional of U.S. patent application Ser. No. 13/216,378 filed Aug. 24, 2011.1. Field of the InventionThe present invention relates to novel processes for preparing cyclopentanones of Formula 1,which are useful for the preparation of benzindene Prostaglandins. The invention also relates to novel cyclopentanones prepared from the processes.2. Description of the Prior ArtFlolan (Epoprostenol) is the first drug approved by Food and Drug Administration for the treatment of pulmonary hypertension. However, Epoprostenol is extremely unstable and normally has a half-life of about 3˜5 minutes and needs to be administered via continuous intravenous administration and be stored at lower temperatures. Benzindene Prostaglandins, such as UT15 (Treprostinil), are derivatives of Epoprostenol and are a new class of drugs for the treatment of pulmonary hypertension. Benzindene prostaglandins are more stable and thus more convenient and safer in utilization as compared to Epoprostenol.As shown in Scheme 1, cyclopentanones of Formula 1a are important intermediates for the synthesis of benzindene prostaglandins, such as UT15 (Tetrahedron Letters (1982), 23(20), 2067-70):However, as shown in Scheme 2, the synthesis of cyclopentanones of Formula 1a should be started with the intermediate B and undergoes eight steps (43, No. 11, 1978), and would involve more than 20 chemical steps, including the steps for the synthesis of the intermediate B. Such synthesis is very complicated and only achieves a low yield.Consequently, there is a demand in the industry for processes for the preparation of cyclopentanones of Formula 1 and benzindene prostaglandins that involve less steps and are more convenient to operate.The present invention provides novel processes of preparing optically active cyclopentanones 1 and novel cyclopentanones.The ...

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Номер записи: 24
26-12-2013 дата публикации

Reduction of c-0 bonds by catalytic transfer hydrogenolysis

Номер: US20130345445A1
Автор: Anna Lundstedt, Joseph Samec, Supaporn SAWADJOON
Принадлежит: KAT2BIZ AB

The present invention relates to a method of reducing a C—O bond to the corresponding C—H bond in a substrate which could be a benzylic alcohol, allylic alcohol, ester, or ether or an ether bond beta to a hydroxyl group or alpha to a carbonyl group.

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Номер записи: 25
30-01-2014 дата публикации

OLEFIN CONDITIONING IN A FAST CATALYTIC PYROLYSIS RECYCLE PROCESS

Номер: US20140031583A1
Автор: Mazanec Terry, Norenberg Greg, Pesa Fred, Whiting Jeff
Принадлежит:

This invention relates to improvements in the fast pyrolysis of biomass. In this invention, olefins are separated from the effluent stream of a pyrolysis reactor and at least a portion of the olefins are treated and the resulting treated stream recycled to the pyrolysis reactor for further conversion to valuable, useful products. 1. A method for producing one or more fluid hydrocarbon products from a hydrocarbonaceous material , comprising:feeding a hydrocarbonaceous material is fed to a reactor;pyrolyzing at least a portion of the hydrocarbonaceous material within the reactor under reaction conditions sufficient to produce one or more pyrolysis products;separating the products into at least a first fraction and a second fraction, where the first fraction comprises at least one olefin;treating the first fraction by adding a chemical compound and/or reacting at least some of the olefins in the first fraction to produce a treated fraction; andadding the treated fraction to a pyrolysis reactor.2. The method of wherein the treated fraction is recycled to the same reactor that produced the pyrolysis products.3. The method of wherein the step of treating comprises one or any combination of the following steps: conversion of olefins to alcohols or ethers; addition of radical inhibiting agents; low temperature (80-400° C.) polymerization of olefins;reaction with CO to form carboxylic acids; alkylation to form alkylated aromatics, and hydrogenation of alkynes to olefins.4. The method of wherein a gaseous product stream from the reactor is separated into an olefin poor and olefin rich stream claim 1 , and at least a portion of the olefin rich stream coming from an olefins separator is treated before mixing with a full recycle gas stream claim 1 , thereby reducing the volume to be treated.5. The method of wherein one or more fluid hydrocarbon products are produced from the pyrolysis products by a treatment selected from the group consisting of dehydration claim 1 , ...

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Номер записи: 26
06-03-2014 дата публикации

Dehydrogenation Catalyst and Process

Номер: US20140066663A1
Автор: Dakka Jihad M., DeCaul Lorenzo C., Helton Terry E., Kuechier Keith H., Waliace Jenna L.
Принадлежит: ExxonMobil Chemical Patents Inc.

A catalyst composition comprises (i) a support; (ii) a dehydrogenation component comprising at least one metal or compound thereof selected from Groups 6 to 10 of the Periodic Table of Elements; and (iii) tin or a tin compound, wherein the tin is present in an amount of 0.01 wt % to about 0.25 wt %, the wt % based upon the total weight of the catalyst composition. 1. A catalyst composition comprising: (i) a support; (ii) a dehydrogenation component comprising at least one metal or compound thereof selected from Groups 6 to 10 of the Periodic Table of Elements; and (iii) tin or a tin compound , wherein the tin is present in an amount of 0.01 wt % to about 0.25 wt % , the wt % based upon the total weight of the catalyst composition.2. The catalyst composition of claim 1 , wherein the tin is present in an amount of about 0.05 wt % to about 0.25 wt % claim 1 , based upon the total weight of the catalyst composition.3. The catalyst composition of claim 1 , wherein the tin is present in an amount of about 0.05 wt % to about 0.15 wt % of tin based upon the total weight of the catalyst composition.4. The catalyst composition of claim 1 , wherein the support is selected from the group consisting of silica claim 1 , a silicate claim 1 , an aluminosilicate claim 1 , zirconia claim 1 , carbon claim 1 , and carbon nanotubes.5. The catalyst composition of claim 1 , wherein the dehydrogenation component comprises at least one of platinum claim 1 , palladium and compounds thereof.6. The catalyst composition of claim 1 , wherein the dehydrogenation component is present in an amount of greater than 0.01 wt % to about 2 wt % claim 1 , based upon the total weight of the catalyst composition.7. The catalyst composition of claim 1 , wherein the composition provides a reduced selectivity to one or more of pentane claim 1 , pentene and carbon monoxide.8. A method for preparing a catalyst composition claim 1 , the method comprising:(a) treating a support with tin or a compound thereof;(b) ...

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Номер записи: 27
27-03-2014 дата публикации

METHOD OF EXTRACTING PHENOLIC FRACTIONS OF EXTRA VIRGIN OLIVE OIL

Номер: US20140088299A1
Автор: Gutierrez Thomas, Harrell C. Chad, Hillhouse M. Christine, Klapish Timothy A.
Принадлежит: PhytoChem Pharmaceuticals, Inc.

The present invention relates to isolating phenolics from extra virgin olive oil (EVOO) having a low triglyceride and non-polar content. The method includes an ethanol/water extraction with a heptane wash 1. A method for isolating phenolics from EVOO , wherein the isolated phenolics have a low triglyceride and non-polar content comprising:a) selecting a desired quantity of EVOO for extraction;b) extracting the EVOO a plurality of times with an ethanol/water solution;c) isolating the ethanol/water solution after each extraction;d) rinsing the ethanol/water solution with a heptane solution;e) isolate the ethanol/water solution from the heptane; andf) evaporate the ethanol/water solution to remove the phenolics from the solution.2. A method according to wherein the plurality isolated solutions of step c) are combined before step d).3. A method according to wherein the evaporation is carried out by a method selected from the list comprising rotary evaporation and speed vacuum evaporation.4. A method according to wherein the ethanol comprises about 50 to 90 percent of the ethanol/water solution.5. A method according to wherein the ethanol comprises about 80 percent of the ethanol/water solution.6. A method according to which further comprises the addition of further ethanol/water solution to the isolated solution in step e) during the evaporation process.7. A phenolic extract of EVOO manufactured by the method of .8. A polar phenolic extract of EVOO comprising EVOO that has been extracted with an ethanol/water solution than then has been washed with a solution of heptane. This application claims priority of U.S. provisional application No. 61/448,265 filed on Mar. 2, 2011 and included herein in its entirety by reference.A portion of the disclosure of this patent contains material that is subject to copyright protection. The copyright owner has no objection to the reproduction by anyone of the patent document or the patent disclosure as it appears in the Patent and ...

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Номер записи: 28
03-04-2014 дата публикации

Transition-metal free reductive cleavage of aromatic c-o, c-n, and c-s bonds by activated silanes

Номер: US20140091256A1
Автор: Alexey FEDOROV, Anton Toutov, Nicholas A. Swisher, Robert H. Grubbs
Принадлежит: California Institute of Technology CalTech

The present invention describes chemical systems and methods for reducing C—O, C—N, and C—S bonds, said system comprising a mixture of (a) at least one organosilane and (b) at least one strong base, said system being substantially free of a transition-metal compound, and said system optionally comprising at least one molecular hydrogen donor compound, molecular hydrogen, or both.

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Номер записи: 29
10-04-2014 дата публикации

METHOD FOR HYDROXYLATION OF PHENOL

Номер: US20140100392A1
Автор: Hsieh Cheng-Fa, Lin I-Hui, Yao Pin-To
Принадлежит: China Petrochemical Development Corporation, Taipei (Taiwan)

A method for hydroxylation of phenol is disclosed. The method includes the step of performing a reaction of phenol and hydrogen peroxide to form diphenol in the presence of solid catalyst with zeolite framework, wherein the solid catalyst includes silicon oxide, titanium oxide and cobalt oxide. The solid catalyst used in the preparation of diphenol of the present invention has high conversion rate of diphenol, selectivity of diphenol and higher utilization rate of hydrogen peroxide without using high concentration of hydrogen peroxide. 1. A method for hydroxylation of phenol , comprising:performing a reaction of phenol and hydrogen peroxide to form diphenol in the presence of a solvent and a solid catalyst,wherein the solid catalyst has zeolite framework and comprises silicon oxide, titanium oxide and cobalt oxide.2. The method of claim 1 , wherein the solid catalyst has MFI zeolite framework.3. The method of claim 1 , wherein the solid catalyst is obtained from a hydrothermal reaction of titanium source claim 1 , silicon source and cobalt source claim 1 , wherein a molar ratio of titanium from the titanium source to silicon from the silicon source is 0.01 to 0.05 claim 1 , and a molar ratio of cobalt from the cobalt source to the silicon from the silicon source is 0.00001 to 0.002.4. The method of claim 1 , wherein a molar ratio of hydrogen peroxide to phenol is 0.2 to 1.5. The method of claim 1 , wherein an amount of the solid catalyst is 0.5% to 10% of a total weight of phenol and hydrogen peroxide.6. The method of claim 1 , wherein the reaction is performed at a temperature in a range from 20° C. to 100° C.7. The method of claim 1 , wherein the solvent is one or more selected from the group consisting of alcohol claim 1 , ketone claim 1 , nitrile claim 1 , organic acid and water. 1. Field of the InventionThis invention relates to a method for hydroxylation of phenol and, more particularly, to a method for catalyzing the hydroxylation of phenol by using solid ...

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Номер записи: 30
07-01-2016 дата публикации

Process for Making Alkylated Aromatic Compound

Номер: US20160001276A1
Автор: Gabor Kiss, Tan-Jen Chen, Terry E. Helton, Thomas E. Green, William A. Lamberti, William C. Horn
Принадлежит: ExxonMobil Chemical Patents Inc

A process for producing an alkylated aromatic compound comprises contacting an aromatic starting material and hydrogen with a plurality of catalyst particles under hydroalkylation conditions to produce an effluent comprising the alkylated aromatic compound, the catalyst comprising a composite of a solid acid, an inorganic oxide different from the solid acid and a hydrogenation metal, wherein the distribution of the hydrogenation metal in at least 60 wt % of the catalyst particles is such that the average concentration of the hydrogenation metal in the rim portion of a given catalyst particle is Crim, the average concentration of the hydrogenation metal in the center portion of the given catalyst particle is Ccenter, where 0.2≦Crim/Ccenter<2.0. Also disclosed are hydroalkylation catalyst and process for making phenol and/or cyclohexanone using the catalyst.

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Номер записи: 31
13-01-2022 дата публикации

Method for decomposing phenolic by-product

Номер: US20220009868A1
Автор: Joon Ho Shin, Min Suk Kang, Sang Beom Lee
Принадлежит: LG Chem Ltd

The present disclosure provides a method for decomposing a phenolic by-product, the method including: a step S10 of injecting and mixing a bisphenol A by-product produced in a bisphenol A production process, a mixed by-product stream of phenol by-products produced in a phenol production process, a decomposition apparatus side discharge stream, and a process water stream in a mixing apparatus; a step S20 of injecting a mixing apparatus discharge stream discharged from the mixing apparatus into a phase separation apparatus and phase-separating the mixing apparatus discharge stream into an oil-phase stream and a liquid-phase stream; a step S30 of feeding the oil-phase stream, which is phase-separated in the step S20 and discharged from the phase separation apparatus, to a decomposition apparatus to decompose the oil-phase stream; and a step S40 of circulating the decomposition apparatus side discharge stream obtained by the decomposition in the step S30 to the mixing apparatus in the step S10.

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Номер записи: 32
01-01-2015 дата публикации

Hydroalkylation Process

Номер: US20150005531A1
Автор: Becker Christopher L., Kuechler Keith H., Lattner James R., Nair Hari
Принадлежит: ExxonMobil Chemical Patents Inc.

In a process for producing phenol, benzene is hydroalkylated with hydrogen in the presence of a catalyst under conditions effective to produce a hydroalkylation reaction product comprising cyclohexylbenzene and cyclohexane. At least a portion of the cyclohexane from said hydroalkylation reaction product is then dehydrogenated to produce a dehydrogenation effluent comprising benzene, toluene and hydrogen. At least a portion of the dehydrogenation effluent is washed with a benzene-containing stream to transfer at least a portion of the toluene from the dehydrogenation effluent to the benzene-containing stream. 1. A hydroalkylation process comprising:(a) hydroalkylating benzene with hydrogen in the presence of a catalyst under conditions effective to produce a hydroalkylation reaction product comprising cyclohexylbenzene and cyclohexane;(b) contacting at least a portion of the hydroalkylation reaction product with a dehydrogenation catalyst to produce a dehydrogenation effluent having at least a portion of the cyclohexane converted to benzene and hydrogen, wherein the dehydrogenation effluent further comprises toluene; and(c) washing at least a portion of the dehydrogenation effluent with a benzene-containing stream to produce a toluene-depleted dehydrogenation effluent and a wash stream containing at least a portion of the toluene from the dehydrogenation effluent, wherein the at least a portion of the dehydrogenation effluent is in the vapor phase and the benzene-containing stream is in the liquid phase.2. The process of claim 1 , wherein the at least a portion of the dehydrogenation effluent contains at least 50 wt % hydrogen claim 1 , the wt % based upon the weight of the at least a portion of the dehydrogenation effluent.3. The process of claim 1 , wherein at least a portion of the toluene in the dehydrogenation effluent is formed from the decomposition of the cyclohexylbenzene.4. The process of claim 1 , wherein the wash stream contains at least 80 wt % of the ...

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Номер записи: 33
14-01-2016 дата публикации

PROCESS FOR PURIFYING HYDROCARBONS

Номер: US20160008735A1
Автор: Lindholm Tero, Pakala Tero, Pakala Timo, Saukonoja Jouni
Принадлежит:

A process for washing hydrocarbons said process comprising: (I) distilling a crude acetone mixture preferably obtained from the cleavage of cumene hydroperoxide and containing hydrocarbons and water so as to form a bottoms fraction containing said hydrocarbons in an organic phase and an aqueous phase; (II) contacting at least a part of said bottoms fraction with an aqueous metal hydroxide solution so as to provide a concentration of 0.1 to 5 wt % MOH, where M is an alkali metal, in the aqueous phase; (III) separating the aqueous phase and the organic phase; (IV) contacting at least a part the organic phase from step (III) with an aqueous metal hydroxide solution so as to provide a concentration of 6 to 20 wt % MOH in the aqueous phase; (V) separating the organic phase and aqueous phase formed in step (IV); (VI) washing at least a part of the organic phase of step (V) with water. 1. A process comprising:(I) distilling a crude acetone mixture containing hydrocarbons and water so as to form a bottoms fraction containing said hydrocarbons in an organic phase and an aqueous phase;(II) contacting at least a part of said bottoms fraction with an aqueous metal hydroxide solution so as to provide a concentration of 0.1 to 5 wt % MOH, where M is an alkali metal, in the aqueous phase;(III) separating the aqueous phase and the organic phase;(IV) contacting at least a part the organic phase from step (III) with an aqueous metal hydroxide solution so as to provide a concentration of 6 to 20 wt % MOH, where M is an alkali metal, in the aqueous phase;(V) separating the organic phase and aqueous phase formed in step (IV);(VI) washing at least a part of the organic phase of step (V) with water.2. A process as claimed in wherein the hydrocarbons comprise cumene and alpha methyl styrene (AMS).3. A process as claimed in said process comprising:(I) distilling a crude acetone mixture obtained from the cleavage of cumene hydroperoxide and containing hydrocarbons and water so as to form a ...

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Номер записи: 34
12-01-2017 дата публикации

Process for producing 2,5-dihalophenolethers

Номер: US20170008824A1
Автор: David Cortes, Eric George Klauber, Gerald SCHMELEBECK, Junmin JI, Michael Rack, Nicole HOLUB, Thomas Zierke
Принадлежит: BASF SE

The present invention relates to a process for providing a compound of formula (IV): wherein R 1 and R 2 are each independently C 1 -C 4 alkyl, and Hal is independently Cl or Br, the process comprising the steps of: (i) reacting a compound of formula (II) wherein R 1 and Hal is defined as above, to obtain a compound of formula (III) wherein R 1 and Hal is defined as above, and (ii) reacting the compound of formula (III) to obtain the compound of formula (IV).

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Номер записи: 35
12-01-2017 дата публикации

ELECTROCHEMICALLY ACTIVE AGENTS FOR PH MODULATION IN BIOLOGICAL BUFFERS

Номер: US20170008825A1
Автор: Ahmad Habib, Fomina Nadezda, Johnson Christopher, Kavusi Sam, Lang Christoph, Maruniak Autumn, RAGHUNATHAN Ashwin
Принадлежит:

Device and methods for use in a biosensor comprising a multisite array of test sites, the device and methods being useful for modulating the binding interactions between a (biomolecular) probe or detection agent and an analyte of interest by modulating the pH or ionic gradient near the electrodes in such biosensor. An electrochemically active agent that is suitable for use in biological buffers for changing the pH of the biological buffers. Method for changing the pH of biological buffers using the electrochemically active agents. The methods of modulating the binding interactions provided in a biosensor, analytic methods for more accurately controlling and measuring the pH or ionic gradient near the electrodes in such biosensor, and analytic methods for more accurately measuring an analyte of interest in a biological sample. 1. An electrochemically active composition comprising a quinone derivative , wherein:a reactivity between a nucleophile and the quinone derivative is reduced compared to a reactivity between the nucleophile and an unsubstituted quinone from which the quinone derivative is derived, andthe composition is configured such that the pH of the composition is electrochemically modulated via the quinone derivative.3. The composition of claim 2 , wherein all of the R groups of the quinone derivative are different from each other.4. The composition of claim 2 , wherein two or more of the R groups of the quinone derivative are the same.5. The composition of claim 1 , wherein the composition is an aqueous solution.6. The composition of claim 1 , further comprising an additive selected from the group consisting of: an aqueous buffer claim 1 , an organic solvent claim 1 , an electrolyte claim 1 , a buffer salt claim 1 , a bioreagent claim 1 , a biomolecule claim 1 , a surfactant claim 1 , a preservative claim 1 , a cryoprotectant claim 1 , and combinations thereof.7. The composition of claim 1 , wherein the one or more nucleophiles are selected from the group ...

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Номер записи: 36
14-01-2016 дата публикации

Process for Making Alkylated Aromatic Compound

Номер: US20160009613A1
Автор: Chen Tan-Jen, Green Thomas E., Helton Terry E., Horn William C., Kiss Gabor, Lamberti William A.
Принадлежит:

A process for producing an alkylated aromatic compound comprises contacting an aromatic starting material and hydrogen with a plurality of catalyst particles under hydroalkylation conditions to produce an effluent comprising the alkylated aromatic compound, the catalyst comprising a composite of a solid acid, an inorganic oxide different from the solid acid and a hydrogenation metal, wherein the distribution of the hydrogenation metal in at least 60 wt % of the catalyst particles is such that the average concentration of the hydrogenation metal in the rim portion of a given catalyst particle is Crim, the average concentration of the hydrogenation metal in the outer portion of a given catalyst particle is Couter, the average concentration of the hydrogenation metal in the center portion of the given catalyst particle is Ccenter, where Crim/Ccenter≧2.0 and/or Couter/Ccenter2.0. Also disclosed are rimmed catalyst and process for making phenol and/or cyclohexanone using the catalyst. 1. A process for producing an alkylated aromatic compound , the process comprising contacting an aromatic starting material and hydrogen with a plurality of catalyst particles under hydroalkylation conditions to produce an effluent comprising the alkylated aromatic compound , the catalyst comprising a composite of a solid acid , an inorganic oxide different from the solid acid and a hydrogenation metal , wherein the distribution of the hydrogenation metal in at least 60 wt % of the catalyst particles is such that:the average concentration of the hydrogenation metal in the rim portion of a given catalyst particle is Crim;the average concentration of the hydrogenation metal in the outer portion of a given catalyst particle is Couter; andthe average concentration of the hydrogenation metal in the center portion of the given catalyst particle is Ccenter; andat least one of the following conditions is met:(i) Crim/Ccenter≧2.0; and(ii) Couter/Ccenter≧2.0.2. The process of claim 1 , wherein the ...

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Номер записи: 37
14-01-2021 дата публикации

Menaquinol Compositions and Methods of Treatment

Номер: US20210009494A1
Автор: Drouet Keith E., Rudey John M., Tumlin James A.
Принадлежит: Epizon Pharma, Inc.

The present application discloses methods for the efficient preparation of high purity compounds of the Formula I, and their methods of use. 146.-. (canceled)48. The method of claim 47 , wherein the method comprises administering the menaquinol compound of the Formula I claim 47 , wherein:m is 7, 8, 9 or 10;{'sup': 1', '2, 'Rand Rare both the residue 15;'}{'sup': 1', '2, 'Rand Rare both the residue 16;'}{'sup': 1', '2, 'Rand Rare both the residue 17;'}{'sup': 1', '2, 'Rand Rare both the residue 18;'}{'sup': 1', '2, 'Rand Rare both the residue 20;'}{'sup': 1', '2, 'Rand Rare both the residue 21;'}{'sup': 1', '2, 'Rand Rare both the residue 22;'}{'sup': 1', '2, 'Rand Rare both the residue 23;'}{'sup': 1', '2, 'Rand Rare both the residue 24;'}{'sup': 1', '2, 'Rand Rare both the residue 25;'}{'sup': 1', '2, 'Rand Rare both the residue 26;'}{'sup': 1', '2, 'Rand Rare both the residue 27; and'}{'sup': 1', '2, 'Rand Rare both the residue 28.'}54. The method of claim 47 , wherein the mammal has distal calciphylaxis and/or central calciphylaxis.55. The method of claim 47 , wherein the mammal has diabetes claim 47 , chronic kidney disease or end stage renal disease.57. The method of claim 56 , wherein the method comprises administering the menaquinol compound of the Formula I claim 56 , wherein:m is 7, 8, 9 or 10;{'sup': 1', '2, 'Rand Rare both the residue 15;'}{'sup': 1', '2, 'Rand Rare both the residue 16;'}{'sup': 1', '2, 'Rand Rare both the residue 17;'}{'sup': 1', '2, 'Rand Rare both the residue 18;'}{'sup': 1', '2, 'Rand Rare both the residue 20;'}{'sup': 1', '2, 'Rand Rare both the residue 21;'}{'sup': 1', '2, 'Rand Rare both the residue 22;'}{'sup': 1', '2, 'Rand Rare both the residue 23;'}{'sup': 1', '2, 'Rand Rare both the residue 24;'}{'sup': 1', '2, 'Rand Rare both the residue 25;'}{'sup': 1', '2, 'Rand Rare both the residue 26;'}{'sup': 1', '2, 'Rand Rare both the residue 27; and'}{'sup': 1', '2, 'Rand Rare both the residue 28.'}63. The method of claim 56 , ...

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Номер записи: 38
14-01-2021 дата публикации

BURST ATOMIZATION FRACTIONATION SYSTEM, METHOD AND APPARATUS

Номер: US20210009548A1
Автор: Casserly Thomas B., MCEUEN MARION, Papa Frank, Vogler Jeffrey F.
Принадлежит: FOG ATOMIC TECHNOLOGIES LLC

Systems, methods and apparatus for fractioning mixtures comprising combinations of volatiles, essentially non-volatiles and non-volatile solutes are disclosed. Embodiments of a burst atomization fractionation apparatus comprises an atomization chamber into which a liquid mixture is atomized across a pressure gradient. In various embodiments, a mixture for fractionation comprises mixtures of solvents, solvents and oils, used engine oil, or salt water. In various examples, a solute undergoes a chemical transformation during the fractionation process, such as dehydrogenation, dehydration, or decarboxylation. 1. A burst atomization fractionation apparatus comprising:an atomization chamber having interior walls defining an interior, the atomization chamber fitted with an atomizer fluidically connecting a liquid feed inlet to the interior of the atomization chamber, the atomizer configured to atomize a liquid mixture from the liquid feed inlet into the interior of the atomization chamber in the form of atomized fine particles;a vacuum pump fluidically connecting the interior of the atomization chamber through a vapor outlet to an environment outside the atomization chamber; anda liquid outlet fluidically connecting the interior of the atomization chamber to an environment outside the atomization chamber.2. The burst atomization fractionation apparatus of claim 1 , wherein the atomizer comprises an atomization nozzle or an ultrasonic nebulizer.3. The burst atomization fractionation apparatus of claim 1 , further comprising a liquid feed tank fluidically connected to the liquid feed inlet claim 1 , the liquid feed tank configured to feed a liquid mixture contained in the liquid feed tank to the liquid feed inlet.4. The burst atomization fractionation apparatus of claim 3 , further comprising a pressurized tank of process gas fluidically connected to at least one of the liquid feed tank or the liquid feed inlet claim 3 , the pressurized tank of process gas configured to ...

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Номер записи: 39
08-01-2015 дата публикации

Catalytic Pulsed Flow Hydrogenation Of Lignin Carboxylic Acid Compounds

Номер: US20150011801A1
Автор: Carter M. K.
Принадлежит: Carter Technologies Corporation

Renewable resources comprising bagasse, corn stover, wood sawdust and switch grass are subject to direct catalytic conversion or bio-fermentation producing ethanol leaving complex lignin compounds for disposal. Chemical conversion of lignin compounds (recoverable from digested lignin) to substituted phenols followed by a carbon steel catalyzed pulsed flow hydrogenation produces cresol and substituted creosol compounds. The pulsed flow process produced close to 100 percent reduction of the reactants compared to 25 percent with continuous flow and is applicable to aliphatic carboxylic acid compounds such as natural oils producing valued liquid hydrocarbons. 1. A catalytic , pulsed flow hydrogenation process for substituted carboxylic acid compounds in contact with a carbon steel catalytic surface , a promoter comprising an anhydrous sodium sulfate with no mineral acid or alkaline material and an activator comprising Co(II)-Co(III)-Co(II) made from tri-metal compounds of mixed valence produced from cobalt using hydrogen gas at 225° C. to 350° C. and ambient to 10 atmospheres pressure forming substituted methyl compounds.2. A catalytic , pulsed flow hydrogenation process for substituted lignin acids (recoverable from digested lignin) comprising 4-hydroxy-3 ,5-dimethoxybenzoic acid , 4 ,5-dihydroxy-3-methoxybenzoic acid , 4-hydroxy-3-methoxybenzoic acid or 4-hydroxybenzoic acid compounds in contact with a carbon steel catalytic surface , a promoter comprising an anhydrous sodium sulfate with no mineral acid or alkaline material and an activator comprising Co(II)-Co(III)-Co(II) made from tri-metal compounds of mixed valence produced from cobalt using hydrogen gas at 225° C. to 350° C. and ambient to 10 atmospheres pressure forming substituted methyl carboxylic acid compounds comprising cresols or substituted cresols.3. A catalytic , pulsed flow hydrogenation process for substituted aliphatic carboxylic acid compounds comprising citric acid or oleic acid in contact with a ...

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Номер записи: 40
09-01-2020 дата публикации

Composition for Control and Inhibition of Polymerization of Monomers, and Method of Use and Preparation Thereof

Номер: US20200010386A1
Автор: Subramaniyam Mahesh
Принадлежит:

The present invention relates to an additive composition for controlling and inhibiting polymerization of monomers, wherein the composition comprises a combination of (a) a phenol compound comprising catechol compound with (b1) an aliphatic tertiary amine, (b2) oxide treated derivative of the aliphatic tertiary amine, or (b2) a mixture thereof, wherein the aliphatic tertiary amine contains one or more hydroxyl groups in the alkyl chain of the aliphatic tertiary amine. In one embodiment, the present invention also relates to a method for controlling and inhibiting polymerization of monomers by employing the additive composition of the present invention. In another embodiment, the present invention also relates to a method of using the additive composition of the present invention for controlling and inhibiting polymerization of monomers. In another embodiment, the present invention also relates to methods for controlling and inhibiting polymerization of monomers in a primary fractionator (or an ethylene plant), and for operating a primary fractionator, and for reducing fouling and polymer deposits in a primary fractionator, and to extend a run-length of a primary fractionator or of an ethylene plant. 1. An additive composition for control and inhibition of polymerization of monomers , wherein the composition consisting of a combination of:(a) a phenol compound comprising catechol compound; and(b) an amine selected from the group consisting of:(i) tri-isopropanol amine (TIPA);(ii) ethyl oxide treated derivative of tri-isopropanol amine (EO-TIPA);(iii) propyl oxide treated derivative of tri-isopropanol amine (PO-TIPA); or(iv) a mixture thereof.26-. (canceled)7. The additive composition as claimed in claim 1 , wherein the catechol compound comprises a tertiary butyl catechol (TBC).8. The additive composition as claimed in claim 1 , wherein the tertiary butyl catechol (TBC) is selected from the group comprising 4-tert-butyl catechol; 3 claim 1 ,5-di-tert-butylcatechol; ...

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Номер записи: 41
15-01-2015 дата публикации

METHOD FOR PREPARING A HERBICIDAL COMPOUND

Номер: US20150018569A1
Автор: Baird Mark Stephen, Braganca Radek Messias, Fowler Paul Anthony, Gould Spencer Matthew, Howard Frank Arthur, Tverezovskiy Viacheslav Vitalievich
Принадлежит: BANOR UNIVERSIITY

The present invention discloses a simple method for transforming cashew nut shell liquid into an active herbicidal composition. 2. The method of wherein R is alkyl having from 12 to 18 carbon atoms.3. The method of wherein R′ is alkyl having from 1 to 5 carbon atoms.4. The method of wherein R″ is hydrogen or alkyl having from 1 to 5 carbon atoms.6. The method of wherein alkylation step b) is carried out with alcohol R′OH wherein R′ is alkyl having up to 6 carbon atoms claim 1 , preferably methyl claim 1 , or with alkyl halide R′X wherein X is halogen claim 1 , or with alkyl sulfonate or alkyl sulfate claim 1 , or dialkyl sulfate claim 1 , optionally in a solvent.7. The method of wherein the alkylation step b) is carried out with dialkyl carbonate claim 6 , preferably dimethyl carbonate claim 6 , in the presence of a phase transfer catalyst.8. The method of wherein first oxidation step c) is carried out with oxygen claim 1 , or hydrogen peroxide claim 1 , or CrO claim 1 , or potassium permanganate claim 1 , or ferric chloride claim 1 , or potassium dichromate claim 1 , or nitric acid claim 1 , or with air in the presence of a catalyst selected from salcomine claim 1 , Pt claim 1 , Pd claim 1 , Ru claim 1 , Zr or Rh.9. The method of wherein Thiele (Thiele-Winter) acetoxylation step d) is carried out with acetic anhydride in the presence of sulfuric acid claim 1 , or triflic acid claim 1 , or bismuth triflate claim 1 , or acetic phosphoric anhydride or boron trifluoride.10. The method of wherein deacetylation step e) is carried out with lithium aluminium hydride or in the presence of a Lewis acid or with hydrochloric or another strong acid like sulphuric or para-toluenesulfonic acids in polar solvent.11. The method of wherein steps c claim 1 , d) claim 1 , and e) are replaced by a treatment with air or oxygen in the presence of a catalyst.12. The method of wherein the oxidizing is carried out with ferric chloride.13. The method of wherein the oxidizing is carried out ...

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Номер записи: 42
15-01-2015 дата публикации

Process for Producing Phenol

Номер: US20150018583A1
Автор: Becker Christopher L., Kuechler Keith H., Lattner James R., Nair Hari
Принадлежит:

In a process for producing phenol, benzene is reacted with a source of hydrogen containing methane in the presence of a hydroalkylation catalyst under conditions effective to produce a hydroalkylation reaction effluent comprising cyclohexylbenzene, benzene, hydrogen, and methane. A first stream comprising hydrogen, methane, and benzene is removed from the hydroalkylation reaction effluent and the first stream is washed with a second stream containing cyclohexylbenzene to produce a benzene-depleted hydrogen stream containing hydrogen and methane and a wash stream containing cyclohexylbenzene and benzene. 1. A process for producing phenol , the process comprising:(a) reacting benzene with a hydrogen-containing stream in the presence of a hydroalkylation catalyst under conditions effective to produce a hydroalkylation reaction effluent comprising cyclohexylbenzene, benzene, and hydrogen;(b) removing a first stream from the hydroalkylation reaction effluent, said first stream comprising hydrogen and benzene; and(c) washing at least a portion of the first stream with a second stream containing cyclohexylbenzene to produce a benzene-depleted hydrogen stream and a wash stream containing cyclohexylbenzene and benzene.2. The process of claim 1 , wherein the first stream is substantially in the vapor phase and the second stream is substantially in the liquid phase.3. The process of claim 1 , wherein at least 50 wt % of the benzene contained in said at least a portion of the first stream is transferred to the wash stream in said washing (c) claim 1 , the wt % based upon the weight of said at least a portion of the first stream.4. The process of claim 1 , wherein the second stream contains less than 1 wt % of benzene claim 1 , based upon the weight of the second stream.5. The process of claim 1 , wherein the benzene-depleted hydrogen stream contains less than 0.1 wt % benzene claim 1 , based upon the weight of the benzene-depleted hydrogen stream.6. The process of claim 1 , ...

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Номер записи: 43
16-01-2020 дата публикации

MEANS AND METHODS FOR LIGNIN PYROLYSIS

Номер: US20200017771A1
Автор: Barton Nadja, Becker Judith, De Wild Paul, Fritz Michael, Kohlstedt Michael, Kuhl Martin, Selzer Mirjam, Starck Soeren, Stolzenberger Jessica, Van Duuren Jost, Wittmann Christoph
Принадлежит:

Conversion of organic educts, in particular biomass feedstock, into useful organic compounds via pyrolysis and bio-catalysts. 1. A method of producing a phenolic compound , preferably catechol comprising the steps ofi) Subjecting lignin to a fast pyrolysis process;ii) Condensing the resulting pyrolysis vapors, optionally directly introducing the resulting pyrolysis vapors into at least one aqueous phase, resulting in at least one acquatic phase comprising a phenolic compound, preferably catechol, and at least one organic phase;iii) Separating the resulting at least one acquatic phase comprising a phenolic compound, preferably catechol and the resulting at least one organic phase.2. A method of producing cis-cis muconic acid claim 1 , comprising the steps of steps i) to iii) according to and further comprising the steps ofiiia) Optionally purifying catechol of the acquatic phase;iv) Subjecting at least one acquatic phase comprising catechol of step iii) or purified catechol of step iiia) of said fast pyrolysis process to a biocatalytic conversion by contacting said acquatic phase with a biocatalyst, wherein said biocatalyst is a host cell which expresses an enzyme showing catechol-1,2-dioxygenase activity (EC 1.13.11.1) (catA) to prepare cis-cis muconic acid;iva) Optionally purifying cis-cis muconic acid from the biocatalyst.3. A method of producing adipic acid claim 1 , comprising the steps i) to iii) according to and further comprising the steps ofiiia) Optionally purifying catechol of the acquatic phase;iv) Subjecting at least one acquatic phase comprising catechol of step iii) or purified catechol of step iiia) of said fast pyrolysis process to a biocatalytic conversion by contacting said acquatic phase with a biocatalyst, wherein said biocatalyst is a host cell which expresses an enzyme showing catechol-1,2-dioxygenase activity (EC 1.13.11.1) (catA) to prepare cis-cis muconic acid;iva) Optionally purifying cis-cis muconic acid from the biocatalyst;v) Preparing ...

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Номер записи: 44
10-02-2022 дата публикации

CUMENE-PHENOL COMPLEX WITH THERMAL OXIDATION SYSTEM

Номер: US20220041534A1
Автор: Bauer Cooper W., Borland David K., De Ren Jan, Jackson Tom, Whyman William J., Williams Chad A.
Принадлежит:

A process for the treatment of waste water, spent air, and hydrocarbon containing liquid and gaseous streams in the cumene/phenol complex is described. Various effluent streams are combined in appropriate collection vessels, including a spent air knockout drum, a hydrocarbon buffer vessel, a fuel gas knockout drum, a phenolic water vessel, and a non-phenolic water vessel. Streams from these vessels are sent to a thermal oxidation system. 1. A process for producing phenol comprising:oxidizing a fresh cumene feed stream in an oxidation unit section to form an oxidation product stream comprising cumene hydroperoxide (CHP), dimethylphenylcarbinol (DMPC), and cumene, and at least one of an oxidation waste water stream, an oxidation spent air stream, and a decanter vent stream;concentrating the oxidation product stream in a CHP concentration unit section to form a concentrated CHP stream and a concentration vent gas stream;decomposing the concentrated CHP stream in a decomposition unit section using a decomposition acid to form an acidic crude product stream comprising phenol, acetone, cumene, and AMS;neutralizing the acidic crude product with a neutralization agent in a neutralization unit section to form a neutralized crude product stream;fractionating the neutralized crude product stream in an acetone-phenol fractionation unit section into a fractionation cumene-AMS-phenol stream, and at least one of a fractionation phenolic water stream, a fractionation organic product stream, a fractionation waste water stream, and a fractionation hydrocarbon vent gas stream;separating the fractionation cumene-AMS-phenol stream in a phenol recovery unit section into a cumene-AMS feed stream, and at least one of a recycled sprung phenol stream comprising phenol and cumene, and a phenolic waste water stream;hydrogenating the cumene-AMS feed stream in an AMS hydrogenation unit section to form a MSHP recycled cumene stream; introducing at least one of the fractionation organic product ...

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Номер записи: 45
28-01-2021 дата публикации

PROCESS FOR PREPARING TAPINAROF

Номер: US20210024442A1
Автор: ANDREWS Ian Paul, CALANDRA Nicholas, DAVIS Tyler Andrew, Sudini Ravinder Reddy
Принадлежит:

The present invention provides processes for the preparation of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and novel intermediates used therein. In some embodiments the 3,5-Dihydroxy-4-isopropyl-trans-stilbene is prepared from (E)-2-chloro-2-isopropyl-5-styrylcyclohexane-1,3-dione. Also disclosed are crystal forms of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a salt or solvate thereof and pharmaceutical compositions comprising same. 118.-. (canceled)20. The process of wherein X is Cl.21. The process of wherein the aromatizing comprises contacting the compound of Formula (II) or a salt thereof with quaternary ammonium salt in a solvent.22. The process of claim 21 , wherein the quaternary ammonium salt is tetraethylammonium chloride.24. The process of wherein the halogenating agent is selected from the group consisting of 1 claim 23 ,3-dichloro-5 claim 23 ,5-dimethylhydantoin; N-chlorosuccinimide; and trichloroisocyanuric acid.25. The process of claim 23 , wherein the halogenating is carried out in methanol and the halogenating agent is 1 claim 23 ,3-dichloro-5 claim 23 ,5-dimethylhydantoin.27. The process of claim 26 , wherein R is selected from the group consisting of methyl claim 26 , ethyl claim 26 , propyl claim 26 , or butyl.28. The process of claim 26 , wherein R is methyl or t-butyl.29. The process of claim 26 , wherein the cyclizing comprises contacting the compound of Formula (IV) or a salt thereof with potassium tert-butoxide in 2-methyltetrahydrofuran.31. The process of claim 30 , wherein the esterifying comprises heating the compound of Formula (V) or a salt thereof with aqueous hydrochloric acid in methanol.33. The process of claim 32 , wherein the decarboxylating comprises heating the compound of Formula (VI) or a salt thereof in the presence of triethylamine.35. The process of claim 34 , wherein each of Rand Ris ethyl.36. The process of claim 34 , wherein the hydrolyzing comprises treating the compound of Formula (VII) or a ...

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Номер записи: 46
29-01-2015 дата публикации

METHOD AND SYSTEM FOR PRODUCING GRAPHENE AND FUNCTIONALIZED GRAPHENE

Номер: US20150030769A1
Автор: Beall Gary W.
Принадлежит:

This disclosure includes a process that unexpectedly can produce very inexpensive graphene, functionalized graphenes, and a new compound called graphenol in particulate or dispersions in solvents. The process can also produce graphene layers on metallic and nonmetallic substrates. Further, the graphenol, functionalized graphenes, and graphene can be utilized to form nanocomposites that yield property improvements exceeding anything reported previously. 2. The process of claim 1 , wherein said carbonaceous material comprises lignite or peat.3. The process of claim 1 , wherein said carbonaceous material comprises leonardite.4. The process of claim 3 , wherein said basic solution is chosen from the group consisting of sodium hydroxide claim 3 , potassium hydroxide claim 3 , and ammonium hydroxide.5. The process of claim 3 , wherein said basic solution comprises ammonium hydroxide claim 3 , and further comprising removing said ammonium hydroxide by heating after chemically reducing said at least one of a carbonyl group portion and a carboxylic acid group portion.6. The process of claim 1 , wherein removing said hydrogenation catalyst comprises removing said hydrogenation catalyst by filtering.7. The process of claim 1 , further comprising removing said basic solution via a strong acid ion exchange resin.8. The process of claim 1 , wherein said inert gas comprises a noble gas.9. The process of claim 8 , wherein said noble gas comprises argon.10. The process of claim 1 , wherein said hydrogenation catalyst is chosen from the group consisting of Raney nickel claim 1 , copper chromium oxide claim 1 , and ruthenium oxide.11. The process of claim 1 , further comprising:drying said solution containing graphenol, thereby producing a powder or sheet of graphenol on a substrate; andheating said powder or sheet of graphenol in a second inert gas at approximately 400 to 800° C.,thereby producing said graphene.12. The process of claim 11 , wherein said second inert gas comprises ...

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Номер записи: 47
29-01-2015 дата публикации

PROCESS FOR THE PREPARATION OF POLYHYDROXYSTILBENE COMPOUNDS BY DEPROTECTION OF THE CORRESPONDING ETHERS

Номер: US20150031921A1
Автор: CHAVA Satyanarayana, Dorwal Harish Niranjanlal, Gorantla Seeta Raman, Sabapathy Sandirane
Принадлежит: LAURUS LABS PRIVATE LIMITED

A process for the preparation of polyhydroxystilbene compounds (particularly resveratrol, oxyresveratrol, piceatannol, gnetol and the like) by deprotection of the corresponding ethers using aluminium halide and a secondary amine is provided. 120-. (canceled)22. The process of claim 21 , wherein Ra claim 21 , Rb claim 21 , Re and Re are independently hydrogen claim 21 , and one of Rd claim 21 , Rf claim 21 , Rg and Rh is hydrogen or a OH group.23. The process of claim 22 , wherein Ra claim 22 , Rb claim 22 , Re claim 22 , and Re are independently hydrogen.24. The process of claim 21 , wherein R claim 21 , Rand Rare independently a linear or branched C-Calkyl group; or an aralkyl group claim 21 , wherein an aryl portion in the aralkyl group is optionally substituted by one or more C-Calkoxy or halogen groups.25. The process of claim 24 , wherein R claim 24 , Rand Rare independently methyl claim 24 , ethyl claim 24 , t-butyl or benzyl group.26. The process of claim 21 , wherein the aluminum halide is selected from the group consisting of aluminum chloride claim 21 , aluminum bromide claim 21 , and aluminum iodide.27. The process of claim 26 , wherein the aluminum halide is aluminum chloride.28. The process of claim 21 , wherein the secondary amine is of Formula (R)NH claim 21 , wherein R is a linear or branched alkyl group claim 21 , a linear or branched C-Calkenyl group claim 21 , a C-Calkanol claim 21 , a C-Ccycloalkyl group claim 21 , a cycloalkylalkyl group claim 21 , an aryl group claim 21 , or an aralkyl group.29. The process of claim 28 , wherein the secondary amine of Formula (R)NH is selected from the group consisting of diemylamine claim 28 , diisopropyl amine claim 28 , di-n-propylamine claim 28 , diisobutylarnine claim 28 , diallylamine claim 28 , allylmethyl amine claim 28 , diphenylamine claim 28 , diben2ylamine claim 28 , benzylethyl amine claim 28 , methylbenzyl amine claim 28 , dicyclohexylamine claim 28 , N-t-butyl cyclohexylamine claim 28 , N- ...

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Номер записи: 48
31-01-2019 дата публикации

A Process for Preparing Perhydrofluorene or Alkyl-Substituted Perhydrofluorene

Номер: US20190031576A1
Автор: Jijun Zou, LI Wang, Lun PAN, Qingfa WANG, Xiangwen ZHANG
Принадлежит: TIANJIN UNIVERSITY

The present invention discloses a process for preparing perhydrofluorene or alkyl-substituted perhydrofluorene, comprising the steps of: (1) reacting a phenolic compound or an aromatic hydrocarbon compound or an aromatic ketone compound or an aromatic ether compound with a benzyl compound to carry out an alkylation reaction in the presence of a first catalyst, thereby to produce substituted or unsubstituted diphenyl methane, wherein the first catalyst is an acidic catalyst; and (2) reacting the substituted or unsubstituted diphenyl methane with hydrogen gas to carry out an hydrogenation reaction or a hydrodeoxygenation reaction, thereby to produce perhydrofluorene or alkyl-substituted perhydrofluorene, wherein the second catalyst is a physical mixture of a metal catalyst and an acidic catalyst or a metal catalyst loaded on an acidic catalyst.

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Номер записи: 49
31-01-2019 дата публикации

PROCESS FOR PREPARATION OF PROSTACYCLIN DERIVATIVES

Номер: US20190031589A1
Автор: GURJAR Mukund Keshav, Pramanik Chinmoy Mriganka, Tripathy Narendra Kumar
Принадлежит: Emcure Pharmaceuticals Limited

The invention relates to improved method of synthesis for Treprostinil comprising condensation reaction of the carbonyl compound having allyl, alkyl, crotyl or MEM-protected phenolic hydroxyl group, compound (4) with a hydroxyl-protected alkynol (5) to give the condensation product, compound (6). Subjecting compound (6) to oxidation, reduction, hydroxyl protection and carbonylation, cyclization reactions gave the tricyclic derivative (10). Further reactions comprising reduction, hydrogenation and deprotection of the phenolic and side-chain hydroxyl groups, wherein the sequence and choice of reagents was governed by protecting groups, gave the triol intermediate, compound (14). Cyanoalkylation at phenolic hydroxyl functionality and further hydrolysis yielded the prostacyclin compound, Treprostinil (1) and its pharmaceutically acceptable salts, having desired purity. 111.-. (canceled)13. The process according to for the preparation of Treprostinil (1) and its pharmaceutically acceptable salts claim 12 , comprising claim 12 , treating compound (13) with a deprotecting agent to provide compound (14) claim 12 , further treating with halogenated acetonitrile to provide compound (15) claim 12 , which on alkaline hydrolysis followed by acidification gave Treprostinil (1) and its pharmaceutically acceptable salts.14. The process according to claim 12 , wherein compound (13) is treated with a reagent comprising a thiol derivative selected from ethane thiol claim 12 , decanethiol claim 12 , dodecanethiol and a Lewis acid selected from aluminium chloride and aluminium bromide.16. The process according to claim 12 , wherein R is unsaturated alkyl selected from allyl claim 12 , crotyl claim 12 , propargyl; alkoxyalkyl ether is 2-methoxyethoxymethyl (MEM) claim 12 , methoxymethyl ether (MOM); substituted or unsubstituted arylalkyl claim 12 , selected from benzyl claim 12 , p-methoxy benzyl; alkyl selected from methyl claim 12 , ethyl claim 12 , and tertiary butyl groups.18. The ...

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Номер записи: 50
05-02-2015 дата публикации

USE OF METALLOPORPHYRINS AND SALEN COMPLEXES FOR THE CATALYTIC OXIDATION OF ORGANIC COMPOUNDS

Номер: US20150038688A1
Автор: CHORGHADE Mukund
Принадлежит:

A method of decomposing an organic substrate includes identifying an organic substrate or its constituents having one or more desired or undesired properties; and contacting the organic substrate with an oxidizing agent and a catalyst selected from the group consisting of sterically hindered and electronically activated metallotetraphenylporphyrins, metallophthalocyanines and metallosalen complexes in an aqueous or aqueous-organic solution to produce a treated composition comprising one or more degradation products, wherein the degradation products have one or more desired properties and/or lack the undesired properties of the organic substrate. 1. A method of decomposing an organic substrate comprising:identifying an organic substrate having one or more undesired properties; andcontacting the organic substrate with an oxidizing agent and a catalyst selected from the group consisting of sterically hindered and electronically activated metallotetraphenylporphyrins, metallophthalocyanines and metallosalen complexes in an aqueous solution to produce a treated composition comprising one or more degradation products, wherein the degradation products have one or more desired properties and/or lack the undesired properties of the organic substrate.2. The method of claim 1 , wherein the organic substrate is toxic and the degradation products are less toxic than the organic substrate.3. The method of claim 1 , wherein the organic substrate is an organic dye.4. The method of claim 3 , wherein the degradation products are colorless.5. The method of claim 1 , wherein the degradation products have increased water solubility relative to the organic substrate.6. The method of claim 1 , wherein the organic substrate is a polymer and the degradation polymer is one or more of monomers or oligomers.7. The method of wherein the polymer comprises lignin.8. The method of wherein the polymer comprises plastics.9. The method of claim 6 , wherein the polymer is selected from the group ...

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Номер записи: 51
05-02-2015 дата публикации

Process for Producing Phenol

Номер: US20150038747A1
Автор: Becker Christopher L., Benitez Francisco M., Kuechler Keith H., Lattner James R., Smith Charles Morris
Принадлежит: Exxonmobil Chemical Patents, Inc.

In a process for producing phenol, cyclohexylbenzene is oxidized to form a first reaction product comprising cyclohexylbenzene hydroperoxide and at least a portion of the cyclohexylbenzene hydroperoxide is then cleaved to form a second reaction product comprising phenol and cyclohexanone. At least one of the first and second reaction products comprises cyclohexenone, which is hydrogenated to produce further cyclohexanone. 1. A process for producing phenol , the process comprising:(a) oxidizing cyclohexylbenzene to form a first reaction product comprising cyclohexylbenzene hydroperoxide; and(b) cleaving at least a portion of the cyclohexylbenzene hydroperoxide from (a) to form a second reaction product comprising phenol and cyclohexanone,wherein at least one of the first reaction product and the second reaction product comprises cyclohexenone and the process further comprises:(c) hydrogenating at least a portion of the cyclohexenone to cyclohexanone.2. The process of claim 1 , wherein at least one the first and second reaction products comprises at least 0.01 wt % of cyclohexenone claim 1 , based upon total weight of the reaction product.3. The process of claim 1 , wherein at least one of the first and second reaction products comprises at least 0.05 wt % of cyclohexenone claim 1 , based upon total weight of the reaction product.4. The process of claim 1 , wherein the hydrogenating (c) is conducted to a degree sufficient to hydrogenate at least 70% of the cyclohexenone to cyclohexanone.5. The process of claim 1 , wherein the hydrogenating (c) is conducted to a degree sufficient to hydrogenate at least 90% of the cyclohexenone to cyclohexanone.6. The process of claim 1 , wherein at least one of the first and the second reaction products comprises up to 10 wt % of cyclohexenone claim 1 , based upon total weight of the reaction product.7. The process of claim 1 , wherein the hydrogenating (c) is conducted at hydrogenation conditions comprising a temperature of about 20° ...

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Номер записи: 52
08-02-2018 дата публикации

ACETATE DERIVED COMPOUNDS FROM GERANYLORCINOL. SYNTHESIS PROCESS FOR OBTAINING SAID COMPOUNDS AND USE OF SAID COMPOUNDS AS ANTIFUNGAL AGAINST BOTRYTIS CINEREA

Номер: US20180035669A1
Автор: DIAZ PERALTA Katy Paulina, ESPINOZA CATALAN Luis Javier, OLEA CARRASCO Floreal Andres, PEÑA CORTES Hugo Alberto, TABORGA MORALES Lautaro Liber
Принадлежит:

The present invention discloses a synthesis process for obtaining linear derivative compounds from geranylorcinoles, said linear derivative compounds from geraniylorcinol, the acetylated derivatives compounds therefrom, the method for encapsulating the compounds in a polymer matrix and the use of said encapsulated compounds as antifungal against 1- Synthesis process for obtaining compounds derived from linear geranylorcinols , characterized in that it comprises:preparing a solution by mixing orcinol (1.22 g, 9.8 mmol), with geraniol (1.51 g, 9.8 mmol) and acetonitrile (2 ml),{'sub': '3', 'adding the above solution to a solution of acetonitrile saturated in AgNO(2 ml);'}stirring the solution at room temperature under a nitrogen atmosphere;{'sub': 3', '2, 'slowly and directly injecting BFEtO (0.46 g, 3.2 mmol);'}stirring for 48 hours;adding crushed ice (approximately 30 g) and abundant salt (NaCl);filtering under vacuum;extracting the organic phase with AcOEt (3×20 ml);{'sub': '3', 'washing organic phase with a solution of NaHCO(15 ml, 5%) and water (2×15 ml);'}{'sub': 2', '4, 'drying over anhydrous NaSO; and'}filtering and evaporating to dryness.2- The synthesis process according to claim 1 , wherein the reaction is performed in quadruplicate and the sum of the crude reaction product is purified by column chromatography (CC) using silica gel as the stationary phase and a mixture of ethyl acetate/hexane in increasing polarity gradient (0:20->6:14) as the mobile phase.3. The synthesis process according to claim 2 , wherein five fractions are obtained claim 2 , where fraction I is a viscous oil dark yellow corresponding formula 2 compound; fraction II is a viscous yellow oil corresponding to formula 3 compound; the third fraction is a viscous dark yellow oil corresponding to formula 4 compound; the fourth fraction is a viscous dark yellow oil corresponding to a mixture of formula 1 and 4 compounds; the fifth fraction is a viscous yellow oil corresponding to formula 1 ...

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Номер записи: 53
09-02-2017 дата публикации

PROCESS FOR THE MANUFACTURE OF TERPHENYL COMPOUNDS

Номер: US20170036978A1
Автор: LOUIS Chantal, Thomas David B.
Принадлежит: SOLVAY SPECIALTY POLYMERS USA, LLC

A process for the manufacture of a terphenyl compound [compound (T), herein after] of formula (T): wherein each of R and R′, equal to or different from each other, are selected from the group consisting of halogen, alkyl, aryl, ether, thioether, ester, amide, imide, alkali or alkaline earth metal sulfonate, alkyl sulfonate, alkali or alkaline earth metal phosphonate, alkyl phosphonate, amine and quaternary ammonium; each of j′ and k, equal to or different from each other, are zero or are an integer from 1 to 4, including the steps of (i) reacting at least one organozinc compound of formula (I) with at least one dihalocompound of formula (II) in the presence of a catalyst compound; wherein Y is selected from the group consisting of a chloride, a bromide, an iodide, an alkanesulfonate or a fluoroalkanesulfonate anion, R2 is selected from selected from the group consisting of C-C-alkyl, C-C-cycloalkyl, C-C-halooalkyl and C-Chalocyclo alkyl, each of Z, equal to or different from each other, are selected from the group consisting of a chloride, a bromide, an iodide, an alkanesulfonate or a fluoroalkanesulfonate anion; (ii) a Bayer-Villiger oxidation and (iii) hydrolysis or alcoholysis. 115-. (canceled)17. The process according to claim 16 , wherein the terphenyl compound (T) is selected from a group consisting of 1 claim 16 ,1′:4′ claim 16 ,1″-terphenyl-4 claim 16 ,4″-diol and 1 claim 16 ,1′:3′ claim 16 ,1″-terphenyl-4 claim 16 ,4″-diol.18. The process according to claim 16 , wherein the organozinc compound of formula (I) is selected from the group consisting of zinc claim 16 , (4-acetylphenyl)chloro- claim 16 , (3-acetylphenyl)chloro- claim 16 , (2-acetylphenyl)chloro- claim 16 , (4-acetylphenyl)bromo- claim 16 , (4-acetylphenyl)iodo- claim 16 , 4-(acetylphenyl)methanesulfonato- claim 16 , 4-(acetylphenyl)trifluoromethanesulfonato- claim 16 , (4-propionylphenyl)chloro- claim 16 , (4-pivaloylphenyl)chloro- claim 16 , and (4-trifluoroacetylphenyl)chloro-.19. The process ...

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Номер записи: 54
09-02-2017 дата публикации

NEUTRALIZATION OF ACIDIC CATALYSTS IN THE PRODUCTION OF PHENOL

Номер: US20170036979A1
Автор: Jiang Xin, MU Jianhai
Принадлежит:

An improved method for the production of phenol. The method comprises (a) synthesizing phenol through a process that utilizes an acidic catalyst; (b) neutralizing the acidic catalyst after substantial completion of step (a) by addition thereto of a neutralization composition, wherein the neutralization composition contains an ethyleneamine derivative. 2. The method of wherein the ethyleneamine derivative is selected from the group consisting of: ethylenediamine (EDA) claim 1 , diethylenetriamine (DETA) claim 1 , triethylenetetramine (TETA) aminoethylpiperazine (AEP) claim 1 , tetraethylenepentamine (TEPA) claim 1 , heavy polyamine X (HPA-X) claim 1 , and mixtures of two or more thereof.3. The method of wherein the ethyleneamine derivative is selected from the group consisting of: ethylenediamine (EDA) claim 1 , diethylenetriamine (DETA) claim 1 , triethylenetetramine (TETA) claim 1 , and mixtures of two or more thereof.4. The method of wherein the neutralization composition is substantially free of amine compounds other than ethyleneamines5. The method of wherein the neutralization composition further comprises claim 1 , methylpentamethyenediamine claim 1 , hexamethylenediamine claim 1 , or mixtures thereof.6. The method of wherein step (a) comprises decomposing of cumene hydroperoxide in the presence of an acidic catalyst to form phenol claim 1 , acetone claim 1 , and α-methylstyrene.7. The method of wherein step (a) comprises:(i) oxidizing at least a portion of a feed containing cyclohexylbenzene to produce an oxidation composition containing cyclohexyl-1-phenyl-1-hydroperoxide; and(ii) cleaving the oxidation composition in the presence of an acidic catalyst to produce a cleavage reaction mixture comprising the acidic catalyst, phenol, and cyclohexanone. This invention relates generally to an improved method for the production of phenol.A commonly used phenol production method is decomposition of cumene hydroperoxide to phenol, acetone, and α-methylstyrene in the ...

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Номер записи: 55
24-02-2022 дата публикации

REDOX-ACTIVE THERAPEUTICS FOR TREATMENT OF MITOCHONDRIAL DISEASES AND OTHER CONDITIONS AND MODULATION OF ENERGY BIOMARKERS

Номер: US20220055975A1
Автор: HECHT Sidney M., Miller Guy M.
Принадлежит:

Methods of treating or suppressing mitochondrial diseases, such as Friedreich's ataxia (FRDA), Leber's Hereditary Optic Neuropathy (LHON), mitochondrial myopathy, encephalopathy, lactacidosis, stroke (MELAS), or Kearns-Sayre Syndrome (KSS) are disclosed, as well as compounds useful in the methods of the invention, such as alpha-tocopherol quinone. Methods and compounds useful in treating other disorders are also disclosed. Energy biomarkers useful in assessing the metabolic state of a subject and the efficacy of treatment are also disclosed. Methods of modulating, normalizing, or enhancing energy biomarkers, as well as compounds useful for such methods, are also disclosed. 2. (canceled)3. (canceled)4. (canceled)6. A method of treating a mitochondrial disorder claim 5 , modulating one or more energy biomarkers claim 5 , normalizing one or more energy biomarkers claim 5 , or enhancing one or more energy biomarkers claim 5 , comprising administering to a subject a therapeutically effective amount or effective amount of one or more compounds of .13. A method of treating a mitochondrial disorder claim 12 , modulating one or more energy biomarkers claim 12 , normalizing one or more energy biomarkers claim 12 , or enhancing one or more energy biomarkers claim 12 , by administering to a subject a therapeutically effective amount or effective amount of one or more compounds of .16. A method of treating a mitochondrial disorder claim 15 , modulating one or more energy biomarkers claim 15 , normalizing one or more energy biomarkers claim 15 , or enhancing one or more energy biomarkers claim 15 , by administering to a subject a therapeutically effective amount or effective amount of one or more compounds of .18. (canceled)19. The method of claim 6 , wherein the mitochondrial disorder is selected from the group consisting of inherited mitochondrial diseases; Myoclonic Epilepsy with Ragged Red Fibers (MERRF); Mitochondrial Myopathy claim 6 , Encephalopathy claim 6 , Lactacidosis ...

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Номер записи: 56
06-02-2020 дата публикации

Isolation of pure cannabinoids from Cannabis

Номер: US20200039908A1
Автор: Amira Samir Wanas, Mahmoud A. Elsohly, Mohamed M. Radwan, Waseem Gul
Принадлежит: UNIVERSITY OF MISSISSIPPI

Δ9-Tetrahydrocannabinol (Δ9-THC or THC) and cannabidiol (CBD) are major constituents of the Cannabis plant that have pharmacological properties with potential therapeutic value. This invention is directed to processes for large scale isolation of these two and other cannabinoids from the Cannabis sativa plant. This is accomplished through the discovery that protected amino acid esters of the cannabinoids are easier to separate using normal phase silica column chromatography. Mild base hydrolysis of the esters regenerates the free cannabinoids in a purified form. The invention is also applicable to the isolation of other cannabinoids from Cannabis extracts.

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Номер записи: 57
12-02-2015 дата публикации

Process for Producing Phenol

Номер: US20150045587A1
Автор: Garcia Roberto, Kiss Gabor, Wang Kun
Принадлежит: Exxonmobil Chemical Patents, Inc.

A process for producing phenol is described in which a feed comprising cyclohexylbenzene hydroperoxide is contacted with a cleavage catalyst comprising an aluminosilicate zeolite of the FAU type having a unit cell size less than 24.50 Å under cleavage conditions effective to convert at least part of the cyclohexylbenzene hydroperoxide into phenol and cyclohexanone. 1. A process for producing phenol , the process comprising:(a) contacting a feed comprising cyclohexylbenzene hydroperoxide with a cleavage catalyst comprising an aluminosilicate zeolite of the FAU type having a unit cell size less than 24.50 Å under cleavage conditions effective to convert at least part of the cyclohexylbenzene hydroperoxide into phenol and cyclohexanone.2. The process of claim 1 , wherein the feed comprises greater than 1 wt % of cyclohexylbenzene hydroperoxide claim 1 , based upon total weight of the feed.3. The process of claim 1 , wherein the feed comprises greater than 50 wt % of cyclohexylbenzene claim 1 , based upon total weight of the feed.4. The process of claim 1 , wherein the conversion of the cyclohexylbenzene hydroperoxide in the contacting step (a) is greater than 30%.5. The process of claim 1 , wherein the FAU type zeolite has a unit cell size less than or equal to 24.35 Å.6. The process of claim 1 , wherein the cleavage catalyst is substantially metal-free.7. The process of claim 1 , wherein at least a portion of the cleavage catalyst is contained in a fixed bed.8. The process of claim 1 , wherein the cleavage conditions include a temperature of about 20° C. to about 200° C. and a pressure of about 100 kPa claim 1 , gauge to about 2000 kPa claim 1 , gauge.9. The process of claim 1 , wherein the contacting step (a) is conducted in at least a first reactor and a second reactor connected in series.10. The process of claim 1 , wherein the cleavage catalyst has a pore volume of greater than 0.3 cc/g.11. The process of claim 1 , wherein the phenol is converted to at least one ...

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Номер записи: 58
18-02-2016 дата публикации

Process and Apparatus for Making Phenol and/or Cyclohexanone

Номер: US20160046550A1
Автор: Becker Christopher L., Coleman John S., Davis Jason D., Nair Hari, Patel Bryan A.
Принадлежит:

A process for producing phenol and/or cyclohexanone by cleaving cyclohexylbenzene hydroperoxide in a loop cleavage reactor comprising multiple reaction zones connected in series. In desirable embodiments, fresh cyclohexylbenzene hydroperoxide feed(s) are supplied to reaction zones the final reaction zone, and fresh acid catalyst is supplied only to the final reaction zone. In desirable embodiments, a portion of the effluent exiting the final reaction zone is recycled to the first reaction zone. Each reaction zone is equipped with a heat exchanger downstream of the feed port to extract heat generated from the cleavage reaction. 1. A process for making phenol and/or cyclohexanone , the process comprising:(A) providing a cleavage reactor having a plurality of reaction zones connected in series, the reaction zones comprising a first reaction zone, a final reaction zone and optionally one or more intermediate reaction zone(s) between the first reaction zone and the final reaction zone; wherein:each of the reaction zones comprises a processed feed port, a fresh feed port, a heat exchanger at least partly downstream of the processed feed port and the fresh feed port in the same reaction zone, and an effluent port, except that the heat exchanger for the final reaction zone is optional;the effluent port of any given reaction zone other than the final reaction zone is in fluid communication with the processed feed port of the immediately following reaction zone in the series; andthe effluent port of the final reaction zone is in fluid communication with the processed feed port of the first reaction zone;(B) supplying a fresh reaction feed comprising cyclohexylbenzene hydroperoxide to each reaction zone other than the final reaction zone via the fresh feed port of the reaction zone and producing an effluent at the effluent port of the reaction zone;(C) supplying at least a portion of the effluent exiting the effluent port of each of the reaction zones other than the final ...

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Номер записи: 59
03-03-2022 дата публикации

MODIFIED ORGANOMETALLIC FRAMEWORK AND CATALYST FOR HYDROGENATION REACTION INCLUDING SAME

Номер: US20220062880A1
Автор: HONG Do Young, Hwang Young Kyu, LEE Ma Eum, OH Kyung Ryul, VALEKAR Anil Haribhau
Принадлежит:

The present disclosure relates to an organometallic framework modified using a compound having a hydroxyl group (—OH), a catalyst for a hydrogenation reaction including the same, and a method of manufacturing the same. The catalyst according to the present disclosure has high activity to the hydrogenation reaction even at a low temperature of 30 to 40° C., thus making low-grade waste heat usable.

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Номер записи: 60
03-03-2016 дата публикации

PHENOL DERIVATIVE AND PREPARATION METHOD AND USE IN MEDICINE THEREOF

Номер: US20160060197A1
Автор: LI Fangqiong, Liu Guoliang, LIU Jianyu, LUO Huadong, LUO Xinfeng, QIN Linlin, REN LEI, Tang Peng Cho, WAN Songlin, Wei Yonggang, YI Shixu
Принадлежит: Sichuan Haisco Pharmaceutical Co., Ltd.

The present invention relates to a phenol derivative and the preparation method and use in medicine thereof, and particular to a phenol derivative represented by general formula (A) or a stereoisomer, a solvate, a metabolite, a prodrug, a pharmaceutically acceptable salt or a cocrystal thereof, a preparation method thereof, a pharmaceutical composition comprising the same, and use of the compound or composition of the present invention in the field of the central nervous system; wherein the definitions of substituents in general formula (A) are the same as those in the Description. 19. The compound according to claim 1 , or a stereoisomer claim 1 , a solvate claim 1 , a metabolite claim 1 , a prodrug claim 1 , a pharmaceutically acceptable salt claim 1 , or a cocrystal thereof claim 1 ,wherein the salt includes an ammonium salt, a potassium salt, a sodium salt, a calcium salt, a magnesium salt, a tetramethylammonium salt, a tetraethylammonium salt, a tetrapropylammonium salt, a tetrabutylammonium salt, a tetra(isopentyl)ammonium salt, an ethanolamine salt, a diethanolamine salt, a triethanolamine salt, trimethylamine salt, N-methylglucosamine salt, hydrochloride sulfate, phosphate, acetate, trifluoroacetate, fumarate, hemifumarate, maleate, malate, citrate, succinate, benzenesulfonate, or p-toluenesulfonate.22. A pharmaceutical composition claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a compound according to , or a stereoisomer, a solvate, a metabolite, a pharmaceutically acceptable salt, a cocrystal, or a prodrug thereof; and'}one or more pharmaceutically acceptable vehicles and/or excipients.23. Use of the compound according to claim 1 , or a stereoisomer claim 1 , a solvate claim 1 , a metabolite claim 1 , a pharmaceutically acceptable salt claim 1 , a cocrystal claim 1 , or a prodrug thereof claim 1 , for the manufacture of a medicament forinducing and maintaining anesthesia in an animal or a human,facilitating sedation and hypnosis of ...

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Номер записи: 61
01-03-2018 дата публикации

AMINATION AND HYDROXYLATION OF ARYLMETAL COMPOUNDS

Номер: US20180057444A1
Автор: GAO HONGYIN, Kürti László, ZHOU Zhe
Принадлежит: William Marsh Rice University

In one aspect, the present disclosure provides methods of preparing a primary or secondary amine and hydroxylated aromatic compounds. In some embodiments, the aromatic compound may be unsubstituted, substituted, or contain one or more heteroatoms within the rings of the aromatic compound. The methods described herein may be carried out without the need for transition metal catalysts or harsh reaction conditions. 1. A method of preparing an aminoaromatic group or a hydroxyaromatic group comprising:(A) admixing a metal aromatic compound with an oxaziridine compound to form a first reaction mixture under conditions sufficient to cause a reaction to obtain an anionic intermediate;(B) admixing a weak acid with the anionic intermediate and the first reaction mixture to obtain a second reaction mixture under conditions sufficient to obtain an aminoaromatic group or a hydroxyaromatic group.2. The method of claim 1 , wherein the metal of the metal aromatic compound is attached to one of the carbon atoms of the aromatic ring.3. The method of claim 1 , wherein the metal of the metal aromatic compound is a magnesium halide or lithium.48-. (canceled)9. The method of claim 1 , wherein the metal aromatic compound is substituted.10. (canceled)11. The method of claim 9 , wherein the metal aromatic compound is substituted with a substituent wherein the substituent is amino claim 9 , aminosulfonyl claim 9 , carboxy claim 9 , cyano claim 9 , halo claim 9 , hydroxy claim 9 , hydroxyamino claim 9 , hydroxysulfonyl claim 9 , mercapto claim 9 , nitro claim 9 , oxo claim 9 , or thio; or acyl claim 9 , alkoxy claim 9 , cycloalkoxy claim 9 , alkenyloxy claim 9 , aryloxy claim 9 , aralkoxy claim 9 , acyloxy claim 9 , cycloalkylalkoxy claim 9 , heterocycloalkylalkoxy claim 9 , heterocycloalkoxy claim 9 , alkylthio claim 9 , cycloalkylthio claim 9 , amido claim 9 , alkylamino claim 9 , dialkylamino claim 9 , alkylsulfonyl claim 9 , arylsulfonyl claim 9 , or a substituted version of these groups ...

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Номер записи: 62
02-03-2017 дата публикации

Phenol Composition

Номер: US20170057895A1
Автор: Becker Christopher L., Davis Jason D., Poucher Ashley J., Watts Jonathan J., Weber Jörg F.W.
Принадлежит:

Disclosed is (i) a process of making phenol and/or cyclohexanone from cyclohexylbenzene including a step of removing methylcyclopentylbenzene from (a) the cyclohexylbenzene feed supplied to the oxidation step and/or (b) the crude phenol product (ii) a phenol composition and (iii) a cyclohexylbenzene composition that can be made using the process. 1. A phenol composition comprising phenol at a concentration of C(Phenol) wt % and methylcyclopentylbenzene at a concentration of C(MCPB) ppm , where the percentage and ppm are based on the total weight of the phenol composition , C(Phenol)≧95.00 , and 0.001≦C(MCPB)≦50.2. The phenol composition of claim 1 , wherein the methylcyclopentylbenzene comprises (a) cis-1-methyl-2-phenylcyclopentane at a concentration of C(MCPB2cis) ppm and (b) trans-1-methyl-2-phenylcyclopentane at a concentration of C(MCPB2trans) ppm claim 1 , and at least one of the following conditions (i) claim 1 , (ii) claim 1 , and (iii) is met:(i) 0.001≦C(MCPB2cis)≦45;(ii) 0.001≦C(MCPB2trans)≦45; and(iii) 0.001≦C(MCPB2cis)+C(MCPB2trans)≦45.3. The phenol composition of claim 1 , wherein 0.010≦C(MCPB)≦20.4. The phenol composition of claim 1 , wherein the methylcyclopentylbenzene comprises (a) cis-1-methyl-2-phenylcyclopentane at a concentration of C(MCPB2cis) ppm and (b) trans-1-methyl-2-phenylcyclopentane at a concentration of C(MCPB2trans) ppm claim 1 , and C(MCPB2trans)>C(MCPB2cis).5. The phenol composition of claim 1 , wherein 1.5≦C(MCPB2trans)/C(MCPB2cis)≦1000.6. The phenol composition of claim 1 , wherein the methylcyclopentylbenzene comprises (a) cis-1-methyl-2-phenylcyclopentane at a concentration of C(MCPB2cis) ppm; (b) trans-1-methyl-2-phenylcyclopentane at a concentration of C(MCPB2trans) ppm; (c) cis-1-methyl-3-phenylcyclopentane at a concentration of C(MCPB3cis) ppm; and (d) trans-1-methyl-3-phenylcyclopentane at a concentration of C(MCPB3trans) ppm claim 1 , and at least one of the following conditions (i) claim 1 , (ii) claim 1 , and (iii) is ...

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Номер записи: 63
02-03-2017 дата публикации

Method of Using dihydro-resveratrol or its stilbenoid derivatives and/or chemical variants in treatments of fibrotic and diabetic conditions

Номер: US20170057896A1
Автор: Hongjie ZHANG, Siu Wai TSANG, Yegao Chen
Принадлежит: Hong Kong Baptist University HKBU

A polyphenol derivative of the stilbenoid family, namely trans-3,5,4′-trihydroxybibenzyl, also known as dihydro-resveratrol, is disclosed as a remedial agent. In particular, the usage of dihydro-resveratrol as an anti-fibrotic agent in suppressing the activation of pancreatic stellate cells (PSCs) is presented. One embodiment also relates to the management of pancreatic fibrosis, which is often accompanied with chronic pancreatitis and desmoplastic reaction of pancreatic cancer. Another embodiment has applications in preventing or alleviating or treating pancreatic cancer or pancreatogenic diabetes.

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Номер записи: 64
02-03-2017 дата публикации

Skin-protection composition containing dendrobium-based ingredients

Номер: US20170057906A1
Автор: Hongjie ZHANG, Siu Wai TSANG, Yu Zhu
Принадлежит: Hong Kong Baptist University HKBU

A skin-protection composition is shown that comprises stilbenoid(s) and/or stilbenoid-containing extract(s) obtained from Dendrobium plants, such as Dendrobium officinale and Dendrobium nobile for the management of melanogenesis, skin-darkening and skin-aging. More particularly, the usage of Dendrobium ingredients and stilbenoids is shown to reduce the formation of melanin in melanocytes. The usage of Dendrobium ingredients and stilbenoids is also shown to reduce the generation of reactive oxygen species and oxidative free radicals. The use of Dendrobium -derived extracts or ingredients or stilbenoids is shown in the formulation of skin-protection, skin-whitening and/or anti-skin aging products.

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Номер записи: 65
04-03-2021 дата публикации

Methods of isolating phenols from phenol-containing media

Номер: US20210061743A1
Автор: Bradley Bolling, Danielle Voss, Matthew Dorris, Yuwei WU
Принадлежит: WISCONSIN ALUMNI RESEARCH FOUNDATION

Methods of isolating phenols from phenol-containing media. The methods include combining a phospholipid-containing composition with the phenol-containing medium to generate a combined medium, incubating the combined medium to precipitate phenols in the combined medium and thereby form a phenol precipitate phase and a phenol-depleted phase, and separating the phenol precipitate phase and the phenol-depleted phase. The methods can further include extracting phenols from the separated phenol precipitate phase. The extracting can include mixing the separated phenol precipitate phase with an extraction solvent to solubilize in the extraction solvent at least a portion of the phenols originally present in the phenol precipitate phase.

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Номер записи: 66
05-03-2015 дата публикации

Process for Producing Phenol and Cyclohexanone

Номер: US20150065753A1
Автор: Becker Christopher L., Benitez Francisco M., Chavez Krystle J., Heidman, JR. John L., Kuechler Keith H.
Принадлежит:

In a process for separating a mixture comprising cyclohexanone and phenol, at least a portion of the mixture is distilled in the presence of a solvent including at least two alcoholic hydroxyl groups attached to non-adjacent saturated carbon atoms and at least one hemiketal defined by the formula (I) or the formula (II): 2. The process of claim 1 , wherein the total concentration of the hemiketal and the enol-ether is at least 0.10%.3. The process of claim 1 , wherein said solvent is diethylene glycol and Ris an ethylene group.6. The process of claim 1 , wherein said solvent is 1 claim 1 ,4-butanediol and Ris 1 claim 1 ,4-butylene.9. The process of claim 1 , wherein at least a portion of said hemiketal and/or enol-ether is formed from the reaction of cyclohexanone and said solvent during said distilling step (a).10. The process of claim 1 , wherein said distilling step (a) is conducted in the presence of water.11. The process of claim 10 , wherein water is present in an amount in the range from 0.1 wt % to 20 wt % claim 10 , based on the total weight of feed to the distilling step (a).12. The process of claim 10 , wherein water is added to the distilling step (a) in an amount sufficient to suppress the formation of said hemiketal and/or enol-ether by an amount of at least 50% of that produced by a distillation under the same condition except in the absence of added water.13. The process of claim 1 , wherein said distilling step (a) separates the mixture into a first stream rich in cyclohexanone and a second stream rich in phenol claim 1 , the solvent claim 1 , and said hemiketal and/or enol-ether.14. The process of claim 13 , further comprising (b) distilling said second stream to separate at least part of the phenol therefrom and produce a recovered solvent.15. The process of claim 14 , wherein the recovered solvent further comprises said hemiketal and/or enol-ether and provides at least a portion of said hemiketal and/or enol-ether present in said distilling step ...

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Номер записи: 67
05-03-2015 дата публикации

Hydrogenation Process

Номер: US20150065754A1
Автор: Chen Tan-Jen, Dakka Jihad M., Helton Terry E., Kuechler Keith H., Reine Travis A.
Принадлежит:

The present invention relates to hydrogenation processes including: contacting a first composition with hydrogen under hydrogenation conditions, in the presence of an eggshell hydrogenation catalyst, wherein the first composition has: (i) greater than about 50 wt % of cyclohexylbenzene, the wt % based upon the total weight of the first composition; and (ii) greater than about 0.3 wt % of cyclohexenylbenzene, the wt % based upon the total weight of the first composition; and thereby obtaining a second composition having less cyclohexenylbenzene than the first composition. Other hydrogenation processes are also described. 1. A hydrogenation process comprising:(I) contacting a first composition with hydrogen in the presence of an eggshell hydrogenation catalyst, (i) greater than about 25 wt % of cyclohexylbenzene, the wt % based upon the total weight of the first composition; and', '(ii) greater than about 0.05 wt % in total of at least one olefin, the wt % based upon the total weight of the first composition, and, 'wherein the first composition comprisesthereby obtaining a second composition having a lower concentration of the at least one olefin in total than the first composition.2. The process of claim 1 , wherein the at least one olefin comprises cyclohexenylbenzene claim 1 , the cyclohexenylbenzene has a concentration greater than about 0.05 wt % based on the total weight of the first composition.3. The process of claim 2 , wherein in the contacting step (I) claim 2 , at least a portion of the cyclohexenylbenzene is converted into cyclohexylbenzene.4. The process of claim 1 , wherein in the contacting step (I) claim 1 , the selectivity of the conversion of cyclohexenylbenzene to cyclohexylbenzene is SC1 claim 1 , the selectivity of the conversion of cyclohexenylbenzene to bicyclohexane is SC2 claim 1 , and (SC1−SC2)/SC1≧0.50.5. The process of claim 1 , wherein the concentration of bicyclohexane in the second composition claim 1 , expressed in terms of weight ...

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Номер записи: 68
28-02-2019 дата публикации

POLYMER-SUPPORTED METAL

Номер: US20190060887A1
Автор: MATSUSHIMA Yoshimasa, OHSHIMA Takashi
Принадлежит: TAKASAGO INTERNATIONAL CORPORATION

A macromolecules containing metal and a use thereof as a catalyst, said macromolecules containing metal being obtained by causing a ligand to react with a zinc compound or a cobalt compound, said ligand having an imidazole group that is bonded to a macromolecule via a linker. 2. The polymer-supported metal according to claim 1 , whereinin general formula (I), Polymer is polystyrene, and L is a methylene group.3. A catalyst comprising the polymer-supported metal according to .4. A method comprising acylating a hydroxy group with a carboxylic acid or an ester thereof by using the catalyst according to .5. A method comprising deacylating a carboxylic acid ester by using the catalyst according to .6. A method for carbonate formation claim 3 , comprising reacting a carbonic acid ester with an alcohol by using the catalyst according to . The present invention relates to a novel polymer-supported metal useful as, for example, a catalyst for transesterification reaction, esterification reaction, carbonate formation reaction, and the like.Many metal complexes having metal atom in their molecules have been proposed and developed as highly-active catalysts. Among these, catalysts comprising trifluoroacetate-bridged zinc tetranuclear cluster complexes containing four zinc ions are excellent catalysts that promote various reactions such as transesterification reaction, hydroxy group-selective acylation reaction in the presence of an amino group, acetylation reaction, deacetylation reaction, direct oxazoline formation reaction from a carbonyl compound, and amidation reaction in an environmentally friendly manner with low formation of by-products (for example, Non Patent Literatures 1 to 5, Patent Literatures 1 to 3).The above-described catalysts, which are homogeneous catalysts, exhibit high activity and high selectivity, but are sensitive to moisture, and tend to be deactivated during reaction. For this reason, the catalysts present a problem in recycling. In addition, removal ...

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Номер записи: 69
22-05-2014 дата публикации

Catalyst Support and Process for the Preparation Thereof

Номер: US20140142329A1
Автор: Ganhy Jean-Pierre, Liebens Armin T.
Принадлежит: SOLVAY (SOCIETE ANONYME)

An amorphous catalyst support comprising at least a first oxide selected from the group consisting of: silica, germanium oxide, titanium oxide, zirconium oxide or mixtures thereof, preferably silica gel beads or diatomaceous earth; a group 3 metal oxide; and anions in an amount not greater than 10% by weight of the catalyst support; wherein the group 3 metal oxide is incorporated in the first oxide structure at the molecular level. The catalyst support is prepared by (a) mixing the first oxide, with an anhydrous source of the group 3 metal oxide, and water, at a pH above 11, thus forming a suspension, (b) washing the catalyst support with water, (c) separating the catalyst support from the water, and (d) optionally drying and/or calcining the catalyst support. A catalyst based on such a support has improved catalytic properties. 1. A process for the preparation of a catalyst support , the process comprising:(a) mixing silica gel beads or diatomaceous earth with an anhydrous source of alumina and water, at a pH above 11, thus forming a suspension,(b) optionally washing the catalyst support with water,(c) separating the catalyst support from the water,(d) optionally drying and/or calcining the catalyst support.2. A process as claimed in claim 1 , wherein the temperature in step (a) is in the range of from 30 to 90° C.3. The process as claimed in claim 1 , wherein the temperature in step (a) is in the range of from 55 to 85° C.4. The process as claimed in claim 1 , wherein the anhydrous source of alumina comprises a metal-alumina claim 1 , preferably sodium aluminate.5. The process as claimed in claim 2 , wherein the anhydrous source of alumina comprises a metal-alumina claim 2 , preferably sodium aluminate.6. The process as claimed in claim 1 , wherein the mixture in step (a) is stirred for from 5 to 90 minutes.7. The process as claimed in claim 1 , wherein the mixture in step (a) is stirred for from 15 to 60 minutes.8. The process as claimed in claim 1 , wherein the ...

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Номер записи: 70
22-05-2014 дата публикации

PROCESS FOR THE ALKYLATION OF AROMATIC HYDROCARBONS WITH OLEFINS

Номер: US20140142348A1
Автор: Bencini Elena, Calaresu Paolo, Casalini Alessandro, Del Seppia Alessandro, Fois Giovanni Antonio
Принадлежит: Versalis S.p.A.

Process for the alkylation of aromatic hydrocarbons by means of olefins containing from 2 to 8 carbon atoms, which comprises feeding the hydrocarbon, olefin, and possibly water, to the head of a fixed-bed reactor, operating with a “trickle flow” regime, containing at least one layer of a catalyst comprising a medium- or large-pore zeolite. 1. A process for the alkylation of aromatic hydrocarbons by means of olefins containing from 2 to 8 carbon atoms comprising: feeding the hydrocarbon , the olefin , and optionally water , to a head of a fixed-bed reactor , operating under “trickle flow” regime , containing at least one layer of a catalyst comprising a medium-pore zeolite or a large-pore zeolite.2. The process according to claim 1 , carried out in continuous claim 1 , which comprises:{'sub': 2', '8, 'a. mixing, in liquid phase, at least one aromatic hydrocarbon (A), a C-Colefin (B), a recycled stream (C) coming from a discharge section of the alkylation reactor, and optionally water,'}b. feeding the mixture obtained in step (a), pre-heated to the reaction temperature, to the head of the fixed-bed alkylation reactor, operating under “trickle flow” regime, containing at least one layer of a catalyst comprising a medium-pore or large-pore zeolite;c. cooling the reaction mixture in a discharge section to obtain an organic phase, comprising the alkylated aromatic hydrocarbon and possibly an aqueous phase; andd. subdividing the organic phase into a recycled stream (C), sent to the head of the alkylation reactor for the mixing phase with the reagents, and a final stream, comprising the alkylated aromatic hydrocarbon.3. The continuous process according to claim 1 , which comprises:{'sub': 2', '8, 'a. mixing, in liquid phase, at least one aromatic hydrocarbon (A), and the C-Colefin (B), with molar ratios A/B higher than 1;'}b. diluting the mixture coming from step (a) with a recycled stream coming from a discharge section of the alkylation reactor, and optionally water, so ...

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Номер записи: 71
28-02-2019 дата публикации

METHOD FOR PREPARING PHENOL

Номер: US20190062245A1
Автор: "SUN Fuan", CHEN Qun, DAI Xuan, HE Mingyang, ZHOU Weiyou
Принадлежит:

The present invention relates to the technical field of peroxide decomposition, and discloses a method for preparing phenol, which comprises the following steps: (1) mixing cumene hydroperoxide and liquid acid or solid acid with a solvent to form a homogeneous solution or uniformly dispersed system; (2) loading the homogeneous solution or uniformly dispersed system of cumene hydroperoxide with a homogeneous solution or uniformly dispersed system of acid into a preheating module and preheating in a micro-channel continuous flow mode, preliminarily mixing the preheated materials for reaction in a mixing module in a micro-channel continuous flow mode, and then further mixing the materials for reaction in a series of mixing and reaction module groups in a micro-channel continuous flow mode, to obtain phenol. The method provided in the present invention is easy, simple and safe to operate, can implement continuous production of phenol product at a high yield ratio; in addition, since the reaction in the present invention is a cracking reaction, which releases heat strongly, the safety factor of the process is significantly improved owing to the strong heat release characteristic in conjunction with the unique heat transfer property of the micro-channels. With the method provided in the present invention, the yield of the product is higher than 99%. 1. A method for preparing phenol , comprising the following steps:(1) mixing cumene hydroperoxide and liquid acid or solid acid with a solvent to form a homogeneous solution or uniformly dispersed system;(2) loading the homogeneous solution or uniformly dispersed system of cumene hydroperoxide with a homogeneous solution or uniformly dispersed system of acid into a preheating module and preheating in a micro-channel continuous flow mode, preliminarily mixing the preheated materials for reaction in a mixing module in a micro-channel continuous flow mode, and then further mixing the materials for reaction in a series of mixing ...

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Номер записи: 72
10-03-2016 дата публикации

LIGNIN CONVERSION PROCESS

Номер: US20160068456A1
Автор: Murray Aaron, Ryba Steven
Принадлежит: Biochemtex, S.p.A.

This specification discloses a complete method to manufacture polyester articles from freshly harvested ligno-cellulosic biomass. The process steps include pretreating the biomass and the converting the lignin to one of several possible organic steams by deoxygenating and dehydrogenating the lignin in the presence of a Raney Nickel catalyst, separating the organics, and then processing the organics into polyester feedstocks and converting those feedstocks to polyester. 1. A process for a one-step conversion of a pre-treated lignin feedstream that has been pre-treated by steam explosion , hydrolysis and fermentation into a converted lignin stream , the process comprised of:a. combining in a lignin conversion vessel: the pre-treated lignin feedstream, water supplied from the group consisting of the pre-treated lignin feedstream, a source other than the pre-treated lignin feedstream and mixtures thereof, hydrogen having a hydrogen pressure which at 25° C. is in the range of 21.7 to 104.5 bar, and a first catalyst comprising an elemental metal catalyst, andb. maintaining the combination in the lignin conversion vessel at a first temperature in the range of 245° C. to 300° C. for a time sufficient to create a converted lignin stream,wherein the pre-treated lignin feedstream comprises lignin, cellulose and water wherein the ratio of moles of hydrogen to moles of lignin and cellulose is at least 0.5 and wherein the lignin of the pre-treated lignin feedstream is present as a solid.2. The process according to claim 1 , wherein the first catalyst comprises an elemental metal selected from the group consisting of Platinum claim 1 , Palladium claim 1 , Cesium claim 1 , Copper claim 1 , Nickel claim 1 , Ruthenium claim 1 , Rhodium claim 1 , Gold claim 1 , and Iridium.3. The process according to claim 1 , wherein the weight of the first catalyst to the dry weight of the pre-treated lignin feedstream is in the range of about 0.005 to about 2.0.4. The process according to claim 1 , ...

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Номер записи: 73
08-03-2018 дата публикации

SOLID FORMS OF MENAQUINOLS

Номер: US20180066326A1
Автор: BIANCHI Davide, Bollini Francesca, COLZANI Federica, Daly Simona, Miraglia Niccolo, Ponzone Cesare, Trentin Antonella
Принадлежит: GNOSIS S.P.A.

Disclosed are solid forms of menaquinol and processes for obtaining them by chemical or enzymatic reduction of menaquinone. Said solid forms possess high stability to oxidation which allows effective use of menaquinol in the most common formulations wherein vitamin K2 is used. 2. The process of wherein step a) is performed at a temperature between 2° C. and 75° C.3. The process of wherein the solution of sodium dithionite has a pH ranging between 3 and 8.4. The process of claim 1 , further comprising washing of the crystalline form obtained in step c) with a solution of ascorbic acid followed by drying of the crystals at a temperature not exceeding 40° C.5. The process of wherein claim 1 , in the compound of formula (II) claim 1 , n is 6.6. The process of wherein claim 1 , in the compound of formula (II) claim 1 , n is 3.7. A crystalline form of menaquinol 7 having a DSC profile as shown in claim 1 , showing an endothermic peak at a temperature of 75° C. or higher claim 1 , and an FT-IR spectrum as reported in claim 1 , having a broad peak at 3340-3350 cm claim 1 , three characteristic peaks at 2964 claim 1 , 2916 claim 1 , and 2851 cm claim 1 , and sharp peaks at 1599 claim 1 , 1504 claim 1 , 1326 claim 1 , 1182 claim 1 , 1149 claim 1 , 1096 claim 1 , 1046 claim 1 , 980 claim 1 , 950 claim 1 , and 752 cm.8. A crystalline form of menaquinol 7 having a DSC profile as shown in claim 1 , showing an endothermic peak at a temperature of 78.4° C. or higher and a second endothermic event in the range of 39-45° C.10BacillusBacillus subtilis, Bacillus stearothermophilus, Bacillus amyloliquefaciens, Bacillus megaterium, Bacillus pumilusBacillus licheniformis.. The process of wherein the reducing step is performed using a micro-organism of the genus claim 9 , selected from the group consisting of claim 9 , and11PseudomonasEscherichiaEnterobacter.. The process of wherein the reducing step is performed using a micro-organism selected from the group consisting of a micro-organism ...

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Номер записи: 74
12-03-2015 дата публикации

METHOD FOR PRODUCING BIOBASED CHEMICALS FROM PLANT LIGNIN

Номер: US20150073131A1
Автор: Peterson John R., Wu Jian, Yost Christopher M.
Принадлежит:

The present invention is directed generally to a method of production of value-added, biobased chemicals from lignin sources, including waste lignin. A method of producing biobased aromatic chemicals, biobased aromatic fuels, and/or lignin residues from lignin is also described herein. 1. A method for biorefining , comprising the steps of:providing lignin biomass;processing said lignin biomass; andproducing at least one product from said lignin biomass.2. The method of claim 1 , wherein said lignin biomass is provided from at least one biomass of plant biomass claim 1 , woody plant biomass claim 1 , agricultural plant biomass claim 1 , and cultivated plant biomass.3. The method of claim 1 , wherein said lignin biomass is provided from at least one biomass of fresh biomass claim 1 , pulp and paper mill biomass claim 1 , and cellulosic ethanol refinery biomass.4. The method of claim 1 , wherein said lignin biomass is provided from kraft lignin.5. The method of claim 1 , wherein said lignin biomass is provided from waste lignin.6. The method of claim 5 , wherein said waste lignin is provided from at least one waste lignin of sulfite mill waste lignin claim 5 , kraft mill waste lignin claim 5 , and sugar cane mill waste lignin.7. The method of claim 1 , wherein said processing of said lignin biomass is provided from at least one process of chemical processing claim 1 , catalytic processing claim 1 , biological processing claim 1 , and pyrolytic processing.8. The method of claim 7 , further comprising the step of providing a lignin pretreatment.9. The method of claim 1 , wherein said at least one product from said lignin biomass comprises at least one chemical of biobased aromatic chemicals claim 1 , biobased aromatic fuels claim 1 , and lignin residues.10. The method of claim 9 , wherein said biobased aromatic chemicals comprise at least one chemical of commodity chemicals claim 9 , fine chemicals claim 9 , and specialty chemicals.11. The method of claim 10 , wherein ...

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Номер записи: 75
29-05-2014 дата публикации

Oxidation Of Cyclohexylbenzene

Номер: US20140148569A1
Автор: Benitez Francisco Manuel, Dakka Jihad Mohammed, Mozeleski Edmund John, Patel Bryan Amrutlal
Принадлежит: ExxonMobil Chemical Patents Inc.

In a process for oxidizing a feed comprising cyclohexylbenzene, the feed is contacted with oxygen and an oxidation catalyst in a plurality of reaction zones connected in series, the contacting being conducted under conditions being effective to oxidize part of the cyclohexylbenzene in the feed to cyclohexylbenzene hydroperoxide in each reaction zone. At least one of the plurality of reaction zones has a reaction condition that is different from another of the plurality of reaction zones. The different reaction conditions may include one or more of (a) a progressively decreasing temperature and (b) a progressively increasing oxidation catalyst concentration as the feed flows from one reaction zone to subsequent reaction zones in the series. 1. A process for oxidizing a feed comprising cyclohexylbenzene , the process comprising:contacting the feed with oxygen and an oxidation catalyst in a plurality of reaction zones connected in series, wherein the contacting in at least two of the plurality of reaction zones is conducted under conditions effective to oxidize a portion of the cyclohexylbenzene to cyclohexylbenzene hydroperoxide, and at least one of the plurality of reaction zones has a different reaction condition than another of the plurality of reaction zones.2. The process of claim 1 , wherein the plurality of reaction zones consists of three reaction zones.3. The process of claim 1 , wherein the different reaction condition includes a temperature decrease from at least one of the plurality of reaction zones to the next of the plurality of reaction zones in the series.4. The process of claim 1 , wherein the different reaction condition includes a temperature decrease of at least 5° C. from at least one of the plurality of reaction zones to the next of the plurality of reaction zones in the series.5. The process of claim 1 , wherein the temperature in the first of the plurality of reaction zones in the series is about 100° C. to about 120° C. and the temperature in ...

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Номер записи: 76
29-05-2014 дата публикации

Process for Producing Phenol

Номер: US20140148620A1
Автор: George Harry Gamble, Jihad Mohammed Dakka, Lorenzo Cophard DeCaul, Teng Xu
Принадлежит: ExxonMobil Chemical Patents Inc

In a process for the dehydrogenation of cyclohexanone to produce phenol, cyclohexanone is contacted in a reaction zone under dehydrogenation conditions with a dehydrogenation catalyst comprising (i) a support comprising silica; and (ii) a dehydrogenation component comprising at least one metal selected from Group 10 of Periodic Table of Elements. Contact of the dehydrogenation catalyst with the cyclohexanone is then terminated and the dehydrogenation catalyst is contacted with an inert gas and/or hydrogen at a temperature of at least 300° C. Contact of the dehydrogenation catalyst with additional cyclohexanone is subsequently reestablished.

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Номер записи: 77
17-03-2016 дата публикации

Process for Producing Phenol

Номер: US20160075623A1
Автор: Bryan A. Patel, John S. COLEMAN
Принадлежит: ExxonMobil Chemical Patents Inc

In a process for producing phenol and cyclohexanone, reaction components comprising cyclohexylbenzene hydroperoxide and an acid catalyst are supplied to a cleavage reaction zone, mixed under mixing conditions effective to combine the reaction components into a reaction mixture and at least part of the cyclohexylbenzene hydroperoxide in the reaction mixture is converted under cleavage conditions to into phenol and cyclohexanone; and a cleavage effluent is recovered from the cleavage reaction zone. The cleavage and mixing conditions are controlled such that the ratio t R /t M is at least 10, where t R is the half-life of cyclohexylbenzene hydroperoxide under the cleavage conditions and t M is the time required after injection of a tracer material into the reaction mixture under the mixing conditions for at least 95% by volume of the entire reaction mixture to attain at least 95% of the volume-averaged tracer material concentration.

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Номер записи: 78
24-03-2022 дата публикации

Compositions of Δ10-THC and Δ6a10-THC

Номер: US20220089560A1
Автор: Siegel Alexander William, Valle Alek Enrique, Wall Devin Jay
Принадлежит:

Compositions of Δ10-THC and Δ6a10a-THC are prepared and described. The conversions do not affect existing CBD or CBG in the extract. Various adjustments can be made to the reactions resulting in increased or decreased product and by-product. Various formulations with medical uses are disclosed. 1. The conversion of psychoactive THC to one or more non-psychoactive cannabinoids.2. The method of performed in the presence of at least one other cannabinoid besides said THC claim 1 , without degrading said other existing cannabinoid.3. The method of performed in the presence of CBD claim 1 , cannabigerol claim 1 , or Δ8-THC claim 1 , without degrading more than 75% of said CBD claim 1 , cannabigerol claim 1 , or Δ8-THC.4. A composition comprising Δ10-THC and at least one other cannabinoid.5. The composition of ; wherein said other cannabinoid is Δ6a10a-THC.6. The composition of ; wherein said other cannabinoid is Δ8-THC.7. The composition of ; wherein said other cannabinoid is Δ9-THC.8. The composition of ; wherein said other cannabinoid is cannabinol.9. The composition of ; wherein said other cannabinoid is cannabidiol.10. The composition of ; wherein said other cannabinoid is cannabigerol.11. The composition of ; wherein said other cannabinoid is cannabichromene.12. The composition of ; wherein said other cannabinoid is cannabinol.13. The composition of ; wherein said other cannabinoid is Δ8-THC.14. The composition of ; wherein said other cannabinoid is Δ8-THC.15. The composition of ; wherein said other cannabinoid is Δ8-THC.16. A composition comprising Δ6a10a-THC and at least one other cannabinoid.17. The composition of ; wherein said other cannabinoid is Δ8-THC.18. The composition of ; wherein said other cannabinoid is Δ9-THC.19. The composition of ; wherein said other cannabinoid is cannabinol.20. The composition of ; wherein said other cannabinoid is cannabidiol.21. The composition of ; wherein said other cannabinoid is cannabigerol.22. The composition of ; wherein ...

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Номер записи: 79
22-03-2018 дата публикации

METHOD FOR CULTIVATION OF MONARDA FISTULOSA FOR PRODUCTION OF THYMOQUINONE

Номер: US20180079703A1
Автор: Rohlfsen William
Принадлежит:

A method for cultivating for production of thymoquinone includes planting seeds at rates between about 2.5 and about 5 pounds per acre, preferably about 4 pounds per acre. The heavy rate of planting produces plants bearing oil without weed contamination and reduces herbicide use due to production of natural herbicides by the plants. Seeding and mowing the first season, and harvesting in seasons thereafter reduce costs. The method results in increased production of essential oils including thymoquinone and thymohydroquinone at levels up to about 40% or more of recovered oils, and which may be distilled from the plant. 1MonardafistulosadydimaMonarda fistulosaMonarda. A method for cultivating plants of at least one species of selected from a group consisting of the species and , to increase yield of at least one constituent of essential oil of said plants , said at least one constituent from the group consisting of thymoquinone and thymohydroquinone , said method comprising preparing a field for planting , growing at least about 60 ,000 plants per acre , and harvesting plants grown in said field.2Monarda fistulosa. The method of further comprising planting seed of with a broadcast seeding device at a rate of between about 2.5 pounds and about 5 pounds per acre.3. The method of further comprising using a soil compression device after seeding for at least partially sealing in moisture.4Monarda fistulosa. The method of further comprising planting plug plants of at a rate between about 45 claim 1 ,000 and about 60000 plugs per acre.5. The method of further comprising a plurality of seasons wherein said plants are mowed at least once without harvesting during a first growing season claim 1 , and harvested after each of the remaining plurality of growing seasons.6. The method of wherein the yield of thymoquinone and thymohydroquinone together comprise at least about 30% of the oil yield.7. The method of wherein the oil yielded further comprises less than about 5% thymol.8. ...

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Номер записи: 80
31-03-2022 дата публикации

PROCESS FOR CATALYTIC HYDROGENATION OF HALONITROAROMATICS

Номер: US20220098141A1
Автор: Ahn John H., Wan Kam-To
Принадлежит: MONSANTO TECHNOLOGY LLC

The present invention generally relates to processes for the catalytic hydrogenation of halonitroaromatics. In particular, the present invention includes processes for the catalytic hydrogenation of halonitroaromatics such as 2,5-dicloronitrobenzene to 2,5-dichloroaniline over a platinum-containing catalyst. The present invention also relates to processes for producing 3,6-dichloro-2-methoxybenzoic acid. 1. A process for preparing a haloaminoaromatic compound , the process comprising:feeding hydrogen and a feed mixture comprising a halonitroaromatic compound to a hydrogenation zone; andreacting the halonitroaromatic compound with hydrogen in the presence of a hydrogenation catalyst comprising a noble metal on a support to produce a reaction product comprising the haloaminoaromatic compound, wherein the hydrogenation catalyst has been calcined at a temperature of at least about 500° C.;wherein the process further comprises one or more of the following features:(1) the feed mixture further comprises a solvent comprising an acid; and/or(2) the support having noble metal thereon that is calcined comprises unreduced noble metal prepared by depositing the noble metal onto the support without use of a reducing agent.2. The process of claim 1 , wherein the acid comprises an organic acid selected from the group consisting of formic acid claim 1 , acetic acid claim 1 , propionic acid claim 1 , butyric acid claim 1 , citric acid claim 1 , and mixtures thereof.3. The process of claim 1 , wherein the acid comprises acetic acid.4. The process of claim 3 , wherein the halonitroaromatic compound comprises a halonitrobenzene and the haloaminoaromatic compound comprises a haloaniline and the process further comprising cooling the reaction product to a temperature of about 15° C. or less.5. The process of claim 4 , wherein the reaction product is cooled to a temperature between about 0° C. and about 15° C.6. The process of claim 1 , wherein the hydrogenation catalyst has been calcined ...

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Номер записи: 81
12-06-2014 дата публикации

Process for Producing Phenol and Method for Regenerating Catalyst Deactivated in the Process

Номер: US20140163259A1
Автор: Dakka Jihad Mohammed, Wang Kun
Принадлежит:

A process for producing phenol is described in which a feed comprising alkylbenzene hydroperoxide is contacted with a cleavage catalyst under cleavage conditions effective to convert at least part of the hydroperoxide into phenol, the process is characterized in that at least a part of the deactivated catalyst is regenerated using a oxidizing material comprising hydrogen peroxide and then return to the process. A method of regenerating the cleavage catalyst is also described. 1. A process for producing phenol comprising:(a) contacting a feed comprising alkylbenzene hydroperoxide with a cleavage catalyst comprising of a zeolite having a FAU, *BEA, MFI, MTW, or MOR framework type, and/or a solid-acid comprising a sulfated transition metal oxide under cleavage conditions effective to convert at least part of the alkylbenzene hydroperoxide to phenol;(b) regenerating at least part of the cleavage catalyst by contacting the catalyst with an oxidizing material comprising hydrogen peroxide; and(c) returning at least part of the regenerated catalyst to step (a) after step (b).2. The process of claim 1 , wherein the oxidizing material comprises an aqueous hydrogen peroxide solution.3. The process of claim 2 , wherein the aqueous hydrogen peroxide solution has a concentration of hydrogen peroxide of from 3 wt % to 50 wt % based on the total weight of the aqueous solution.4. The process of claim 1 , wherein the cleavage catalyst comprises a zeolite having a FAU framework type.5. The process of claim 1 , wherein step (b) is conducted at a temperature of from 50° C. to 250° C.6. The process of claim 1 , wherein step (b) is conducted at a pressure of from 200 kPa to 3000 kPa.7. The process of claim 1 , wherein the weight ratio of hydrogen peroxide to the catalyst in step (b) is from 0.01 to 10.8. The process of claim 1 , wherein the catalyst in step (b) is washed with a polar solvent prior to contacting with the oxidizing material.9. The process of claim 8 , wherein the polar ...

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Номер записи: 82
12-03-2020 дата публикации

PROCESS FOR ACID-CATALYZED DECOMPOSITION OF ARYL a- HYDROPEROXIDE WITH CONTINUOUS FLOW TUBULAR REACTOR

Номер: US20200079714A1
Автор: "SUN Fuan", CHEN Qun, DAI Xuan, HE Mingyang, SUN ZHONGHUA, ZHOU Weiyou
Принадлежит: CHANGZHOU UNIVERSITY

The present disclosure relates to a process for acid-catalyzed decomposition of aryl α-hydroperoxide with a continuous flow tubular reactor. The process is a novel process performed in a tubular reactor, taking the aryl α-hydroperoxide such as cumene hydroperoxide (CHP) as a raw material and taking acids as a catalyst, performing acid-catalyzed decomposition of the aryl α-hydroperoxide solution in a short reaction time ranging from tens of seconds to several minutes, thereby obtaining the phenols; wherein an inert component may be filled in the reactor, so that the effects of heat transmission and mass transfer can be enhanced. The aryl α-hydroperoxide and acid are respectively introduced by a metering pump into a mixing module to be mixed, and then enter the tubular reactor to be reacted so as to produce the products such as phenols. 3. The process for acid-catalyzed decomposition of aryl α-hydroperoxide with a continuous flow tubular reactor according to claim 1 , wherein the aryl α-hydroperoxide is cumyl hydroperoxide (CHP).4. The process for acid-catalyzed decomposition of aryl α-hydroperoxide with a continuous flow tubular reactor according to claim 1 , wherein the process further comprises the following step (2):(2) the concentration of each substance in the reaction products is analyzed by a liquid chromatography external standard method, and the aryl α-hydroperoxide is titrated by an iodometric method.5. The process for acid-catalyzed decomposition of aryl α-hydroperoxide with a continuous flow tubular reactor according to claim 3 , wherein the CHP in step (1) is a concentrated oxidation liquid of cumene claim 3 , the solvent is one of acetone and cumene or a mixture thereof; or the oxidation liquid of cumene is used as a source of the CHP.6. The process for acid-catalyzed decomposition of aryl α-hydroperoxide with a continuous flow tubular reactor according to claim 1 , wherein the acid in step (1) is one or more selected from a group consisting of sulfuric ...

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Номер записи: 83
12-03-2020 дата публикации

Menaquinol Compositions and Methods of Treatment

Номер: US20200079718A1
Автор: Drouet Keith E., Tumlin James A.
Принадлежит: Epizon Pharma, Inc.

The present application discloses methods for the efficient preparation of high purity compounds of the Formula I, and their methods of use. 23.-. (canceled)4. The method of claim 1 , wherein the metal catalyst is a nickel(0) catalyst.5. The method of claim 4 , wherein the nickel(0) catalyst is (PhP)Ni(0).610.-. (canceled)11. (canceled)13. The compound of of the Formula I claim 12 , wherein:{'sup': 1', '2, 'Rand Rare both the residue 15;'}{'sup': 1', '2, 'Rand Rare both the residue 16;'}{'sup': 1', '2, 'Rand Rare both the residue 17;'}{'sup': 1', '2, 'Rand Rare both the residue 18;'}{'sup': 1', '2, 'Rand Rare both the residue 20;'}{'sup': 1', '2, 'Rand Rare both the residue 21;'}{'sup': 1', '2, 'Rand Rare both the residue 22;'}{'sup': 1', '2, 'Rand Rare both the residue 23;'}{'sup': 1', '2, 'Rand Rare both the residue 24;'}{'sup': 1', '2, 'Rand Rare both the residue 25;'}{'sup': 1', '2, 'Rand Rare both the residue 26;'}{'sup': 1', '2, 'Rand Rare both the residue 27; and'}{'sup': 1', '2, 'Rand Rare both the residue 28.'}14. The compound of of the Formula I claim 12 , wherein:{'sup': 1', '2', '2', '1, 'Ris H and Ris the residue 15; Ris H and Ris the residue 15;'}{'sup': 1', '2', '2', '1, 'Ris H and Ris the residue 16; Ris H and Ris the residue 6;'}{'sup': 1', '2', '2', '1, 'Ris H and Ris the residue 17; Ris H and Ris the residue 17;'}{'sup': 1', '2', '2', '1, 'Ris H and Ris the residue 11; Ris H and Ris the residue 18;'}{'sup': 1', '2', '2', '1, 'Ris H and Ris the residue 20; Ris H and Ris the residue 20;'}{'sup': 1', '2', '2', '1, 'Ris H and Ris the residue 21; Ris H and Ris the residue 21;'}{'sup': 1', '2', '2', '1, 'Ris H and Ris the residue 22; Ris H and Ris the residue 22;'}{'sup': 1', '2', '2', '1, 'Ris H and Ris the residue 23; Ris H and Ris the residue 2;'}{'sup': 1', '2', '2', '1, 'Ris H and Ris the residue 2; Ris H and Ris the residue 4;'}{'sup': 1', '2', '2', '1, 'Ris H and Ris the residue 25; Ris H and Ris the residue 25;'}{'sup': 1', '2', '2', '1, 'Ris H ...

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Номер записи: 84
12-03-2020 дата публикации

METHOD FOR EXTRACTING COMPOSITIONS FROM PLANTS

Номер: US20200079751A1
Автор: Cullen Mark T., Durkacz Anthony J.
Принадлежит:

Methods for extracting and concentrating cannabinoids using ultrasound-enhanced solvent extraction. Freshly harvested cannabis plant materials, which may be selectively chosen plant parts or the entire plant itself, are shredded to a particular particle size. The plant material is then mixed with a solvent to form a slurry, and thereafter subjected to ultrasound to release intracellular contents into the solvent. Filtering steps are then applied to remove biomass, waxes and chlorophyll. Water removal and solvent recovery steps are further applied to ultimately derive an extract having high concentrations of target cannabinoids, and in particular cannabidiol (CBD). The methods may be deployed on-site in batch or continuous flow processes, and may further be utilized to derive other types of materials from plants, such as essential oils. 126-. (canceled)27. A method for extracting and concentrating CBD from hemp plant material comprising the step:a) harvesting a hemp plant from which said hemp plant material is derived;b) shredding or grinding said harvested plant in step a) to produce particulate plant material;c) mixing said particulate plant material in step b) with water to form a slurry;d) subjecting said slurry produced in step c) to ultrasonic energy, said ultrasonic energy being applied at a frequency ranging from 5 kHz-1 MHz and having a displacement amplitude in the range from about 20 to 100 mm with power being delivered to said slurry in a range from about 90 to about 160 watts per square centimeter of slurry treated, said ultrasound being applied for a duration ranging from 30 seconds to 5 minutes;e) removing wax, biomass and chlorophyll from said slurry treated with ultrasound in step d) to derive a liquid extract; andf) treating said extract produced in step e) to remove water emanating from said hemp plant shredded in step b) and residual water introduced in step c) to produce a concentrated resultant extract.28. The method of wherein in step b) claim ...

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Номер записи: 85
02-04-2015 дата публикации

Hydroalkylating Process

Номер: US20150094494A1
Автор: Kiss Gabor, Kuechler Keith H.
Принадлежит:

An alkylating process such as hydroalkylating process comprising feeding a gas material and a liquid material into the reactor, distributing the liquid material to the upper surface of a bed of a catalyst substantially uniformly. The substantial uniform distribution of the liquid material to the upper surface allows for substantially uniform distribution of liquid reaction medium in the bed, thereby preventing hot spot and undesirable continuous liquid zone, both of which can cause the production of undesired by-products. The invention is particularly useful for the hydroalkylation reaction of benzene in making cyclohexylbenzene, which can be used for making cyclohexanone and phenol. 1. A hydroalkylation process , the process comprising:(I) supplying hydrogen and an aromatic compound into a hydroalkylation reactor;(II) contacting the hydrogen and the aromatic compound with a hydroalkylation catalyst comprising a first hydrogenation metal component and an alkylation component in a first reaction zone in the hydroalkylation reactor to obtain a first reaction mixture comprising hydrogen, an alkylated aromatic compound and an olefin; and(III) contacting the first reaction mixture with a hydrogenation catalyst comprising a second hydrogenation metal component and essentially free of an alkylation component in a second reaction zone in the hydroalkylation reactor to obtain a second reaction mixture.2. The hydroalkylation process of claim 1 , wherein the aromatic compound is selected from benzene claim 1 , toluene claim 1 , o-xylene claim 1 , m-xylene claim 1 , p-xylene claim 1 , ethylbenzene claim 1 , methylethylbenzene claim 1 , and mixtures of at least two thereof.3. The hydroalkylation process of claim 1 , wherein the aromatic compound is benzene claim 1 , the alkylated aromatic compound is cyclohexylbenzene claim 1 , and the olefin is phenylcylohexene.4. The hydroalkylation process of claim 3 , wherein the first reaction mixture has a concentration of ...

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Номер записи: 86
02-04-2015 дата публикации

Process for Producing Phenol and Cyclohexanone

Номер: US20150094495A1
Автор: Christopher L. Becker, Francisco M. Benitez, John L. Heidman, Keith H. Kuechler, Krystle J. CHAVEZ
Принадлежит: ExxonMobil Chemical Patents Inc

In a process for separating a mixture comprising cyclohexanone and phenol, at least a portion of the mixture is distilled in the presence of a solvent including at least two alcoholic hydroxyl groups attached to non-adjacent saturated carbon atoms, water, and in the presence or absence of a hemiketal defined by the formula (I) or the formula (II): wherein R 1 , the same or different at each occurrence, is independently an alkylene group having from 2 to 10 carbon atoms, R 2 is an alkylene group having from 4 to 10 carbon atoms and/or R 3 is hydrogen or the following group: and in the presence or absence of an enol-ether derived from the hemiketal defined by the formula (I) or the formula (II), wherein the total concentration of the hemiketal and enol-ether, expressed in term of weight percentage of the total weight of the feed to the distilling step, is at most 0.01%.

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Номер записи: 87
12-05-2022 дата публикации

METHOD FOR THE PREPARATION OF CANNABIDIOL

Номер: US20220144736A1
Автор: OSTROVSKYI DMYTRO, ZUHSE Ralf
Принадлежит:

The invention relates to a method for the preparation of cannabidiol and an intermediate for the preparation of cannabidiol, wherein two intermediates are obtained, namely a silylated olivetol and a silylated olivetol (2) and brominated olivetol (4) which are stable, storable and which do not have undesirable properties or byproducts. 2. The method according to{'sub': 2', '2, 'wherein (a) includes silylation in the presence of imidazole in dichloromethane (CHCl).'}3. The method according to{'sub': 2', '2, 'wherein (b) includes a bromination with N-bromosuccinimide in dichloromethane (CHCl).'}4. The method according towherein (c) includes desilylation by acid hydrolysis in tetrahydrofuran.5. The method according toand further comprising:{'sub': 2', '2, 'conversion to dibromocannabidiol in dichloromethane (CHCl) in the presence of para-toluenesulfonic acid.'}6. The method according to claim 1 ,{'sub': 3', '8', '19', '3', '2', '5', '3', '9', '16', '2, 'wherein (e) includes debromination of the dibromoicannabidiol in methanol in the presence of at least one base selected from the group consisting of ammonia (NH), diisopropyl ethylamine (CH)N, triethylamine (CH)N and/or diazabicycloundecene (DBU, CHN).'}9. The method according to{'sub': 2', '2, 'wherein (b) includes bromination with N-bromosuccinimide in dichloromethane (CHCl).'}10. The method according towherein (c) includes desilylation by acid hydrolysis in tetrahydrofuran.11. The method according toand further comprising:{'sub': 2', '2, 'conversion to dibromocannabidiol in dichloromethane (CHCl) in the presence of para-toluenesulfonic acid.'}12. The method according towherein (e) includes{'sub': 3', '8', '19', '3', '2', '5', '3', '9', '16', '2, 'debromination of the dibromoicannabidiol in methanol in the presence of at least one base selected from the group consisting of ammonia (NH), diisopropyl ethylamine (CH)N, triethylamine (CH)N and/or diazabicycloundecene (DBU, CHN).'}13. The method according towherein (c) ...

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Номер записи: 88
14-04-2016 дата публикации

Process for Producing Phenol and/or Cyclohexanone

Номер: US20160102034A1
Автор: Becker Christopher L., Benitez Francisco M., Lattner James R., Nair Hari, Nimmon Karen S., Smith Charles Morris
Принадлежит:

In a process for producing phenol, a cleavage feed comprising cyclohexylbenzene hydroperoxide is supplied to a cleavage reaction zone and a cleavage reaction mixture comprising the cleavage feed is contacted in the cleavage reaction zone with a solid acid catalyst under conditions effective to produce a cleavage effluent comprising phenol and cyclohexanone. The cleavage effluent is then divided into at least a cleavage product and a cleavage recycle and the cleavage recycle and a polar solvent is supplied to the cleavage reaction zone to produce the cleavage reaction mixture with the cleavage feed. Preferably, the polar solvent is combined with the cleavage recycle before being charged into the cleavage reaction zone. 1. A process for producing phenol , the process comprising:(a) supplying a cleavage feed comprising cyclohexylbenzene hydroperoxide to a cleavage reaction zone;(b) contacting a cleavage reaction mixture comprising the cleavage feed in the cleavage reaction zone with a solid acid catalyst under conditions effective to produce a cleavage effluent comprising phenol and cyclohexanone;(c) dividing the cleavage effluent into at least a cleavage product and a cleavage recycle; and(d) supplying the cleavage recycle and a polar solvent to the cleavage reaction zone to produce the cleavage reaction mixture with the cleavage feed.2. The process of claim 1 , wherein the polar solvent is supplied to the cleavage reaction zone in (d) in an amount from 100 ppm to 10% by weight of the cleavage reaction mixture.3. The process of claim 2 , wherein the polar solvent is supplied to the cleavage reaction zone in (d) in an amount from 1000 ppm to 5% by weight of the cleavage reaction mixture.4. The process of claim 1 , wherein the polar solvent is water.5. The process of claim 1 , wherein the cleavage effluent comprises unreacted cyclohexylbenzene hydroperoxide.6. The process of claim 1 , wherein at least part of the polar solvent is combined with the cleavage recycle to ...

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Номер записи: 89
16-04-2015 дата публикации

METHOD FOR DIRECT AMMONOLYSIS OF POLYCARBONATE-CONTAINING MATERIALS AND PRODUCTS

Номер: US20150105531A1
Автор: Bell Philip Wesley, GANAPATHY BHOTLA Venkata Ramanarayanan, Sreenivasan PS, STANISLAUS Alexander
Принадлежит:

A method for recovering a dihydroxy aromatic compound and urea from a polycarbonate-containing composition comprising a polycarbonate and a phosphorus-containing flame retardant, comprising contacting the composition with ammonia in the presence of a swelling solvent for a time sufficient to depolymerize the polycarbonate producing a dihydroxy aromatic compound and urea. 1. A method for recovering a dihydroxy aromatic compound from a polycarbonate-containing composition comprising contacting the polycarbonate-containing composition with ammonia and a solvent at a temperature of from 20° C. to 100° C. for a time sufficient to depolymerize the polycarbonate to provide a dihydroxy aromatic compound and urea.2. The method of claim 1 , wherein the composition comprises from 10 to 90 weight percent polycarbonate.3. The method of claim 1 , wherein the composition comprises from 10 to 70 weight percent polycarbonate.4. The method of claim 1 , wherein the composition comprises from 20 to 50 weight percent polycarbonate.5. The method of claim 1 , wherein the composition comprises from 12 to 30 weight percent polycarbonate.6. The method of claim 1 , wherein the solvent is a Calcohol or a ketone.7. The method of claim 6 , wherein the solvent is methanol.8. The method of claim 1 , wherein the method further comprises separating the dihydroxy aromatic compound and the urea from the solid residual polymeric composition by filtration.9. The method of claim 1 , further comprising separating a blend of the alcohol and the urea from the dihydroxy aromatic compound by distillation.10. The method of claim 1 , wherein the polycarbonate is bisphenol A polycarbonate claim 1 , and the dihydroxy aromatic compound is bisphenol-A.11. The method of claim 1 , wherein the phosphorus-containing flame retardant is bisphenol A bis(diphenyl phosphate) claim 1 , resorcinol bis(diphenyl phosphate) claim 1 , or a combination thereof.12. A method for the manufacture of a polycarbonate claim 1 , the ...

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Номер записи: 90
13-04-2017 дата публикации

PROCESS FOR PREPARING 3-CHLORO-2-VINYLPHENOL

Номер: US20170101359A1
Автор: ERVER Florian, Ford Mark James
Принадлежит: Bayer CropScience Aktiengesellschaft

The present invention describes a novel process for preparing 3-chloro-2-vinylphenol which, owing to the chemoselectivity achieved, also allows direct conversion into (3-chloro-2-vinylphenyl)methane-sulphonate. 2. The process according to claim 1 , wherein the base is lithium carbonate claim 1 , sodium carbonate claim 1 , potassium carbonate claim 1 , calcium carbonate claim 1 , triethylamine claim 1 , diethylisopropylamine claim 1 , tri-n-butylamine claim 1 , pyridine claim 1 , picoline claim 1 , lutidine claim 1 , or collidine.3. The process according to claim 1 , wherein the base is triethylamine claim 1 , tri-n-butylamine claim 1 , calcium carbonate claim 1 , or lithium carbonate.4. The process according to claim 1 , wherein the base is lithium carbonate.5. The process according to claim 1 , characterized in that the additive is N claim 1 ,N-dimethylacetamide claim 1 , N claim 1 ,N-dimethylformamide claim 1 , propylene carbonate or sulpholane.6. The process according to claim 1 , characterized in that the additive is N claim 1 ,N-dimethylacetamide.7. The process according to claim 1 , characterized in that a solvent is used in addition to the base and the additive.8. The process according to claim 7 , characterized in that the solvent is methyl tert-butyl ether claim 7 , tetrahydrofuran claim 7 , 2-methyltetrahydrofuran claim 7 , cyclopentyl methyl ether claim 7 , 1 claim 7 ,4-dioxane claim 7 , ethyl acetate claim 7 , n-propyl acetate claim 7 , i-propyl acetate or n-butyl acetate.9. The process according to claim 7 , characterized in that the solvent is n-butyl acetate.10. Use of the compound of the formula (I) according to for preparing pharmaceutical and agrochemical active compounds.11. Use of the compound of the formula (I) according to for preparing agrochemical active compounds.12. Use of the compound of the formula (I) according to for preparing fungicidal active compounds.14. The process according to claim 13 , wherein Q is chloride and A is mesyl. The ...

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Номер записи: 91
04-04-2019 дата публикации

Cannabinoid extraction and distillation

Номер: US20190099695A1
Автор: Hughes Brock, Ko Ryan Delmoral
Принадлежит:

Raw plant material is mixed with ethanol under pressure to extract essential elements. The resulting crude oil and ethanol with the dissolved essential elements is separated from the raw plant material and filtered to remove particulates, waxes, lipids, fats and dissolved impurities. The ethanol is then evaporated from the resulting mixture of crude oil and ethanol, and the remaining crude oil then undergoes decarboxylation and distillation to obtain the essential elements. The ethanol may be chilled before adding it to the raw plant material. 1. A process for extracting cannabinoids from raw cannabis plant material comprising the steps of:drying raw cannabis plant material;grinding the raw cannabis plant material to result in ground plant material;adding ethanol to the ground plant material to form a mixture;pressurizing the mixture;removing solid ground plant material from the mixture to leave a crude oil and ethanol mixture;filtering the crude oil and ethanol mixture to remove unwanted components;evaporating ethanol from the filtered crude oil and ethanol mixture to leave crude oil;decarboxylating the crude oil to leave a residue; anddistilling the residue to obtain cannabinoids.2. The process of claim 1 , wherein cannabinoids in the raw cannabis plant material dissolve in the ethanol in the mixture.3. The process of claim 1 , wherein the solid ground plant material is removed from the mixture by centrifuging the mixture.4. The process of claim 1 , wherein the unwanted components are one or more of pigments claim 1 , chlorophyll claim 1 , fats claim 1 , waxes claim 1 , lipids claim 1 , heavy metals and particulates.5. The process of claim 1 , further comprising subjecting the cannabinoids to a film wipe to separate the cannabinoids into cannabidiol and tetrahydrocannabinol.6. The process of claim 1 , wherein the distilling step comprises:subjecting the residue to a first film wipe to remove volatile terpenes and leave a second residue;subjecting the second ...

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Номер записи: 92
04-04-2019 дата публикации

Cannabinoid extraction process using brine

Номер: US20190099696A1
Автор: Hughes Brock, Ko Ryan Delmoral, Pal Krupal, Samuelsson Alexzander
Принадлежит:

Raw cannabis plant material is mixed with ethanol and spun-dry to extract cannabinoids. The ethanol may be chilled before adding it to the raw cannabis plant material, and a non-polar solvent stage may be used to increase the yield of the extraction. The resulting crude oil and ethanol with the dissolved cannabinoids is separated from the raw cannabis plant material and filtered to remove particulates, waxes, lipids, fats and dissolved impurities. The ethanol is then evaporated from the resulting mixture of oil and ethanol, and the remaining oil then undergoes brine-washing, decarboxylation and distillation to obtain the cannabinoids and other desirable volatile phytochemicals. 1. A process for extracting cannabinoids from raw cannabis plant material comprising the steps of:adding ethanol to dried and ground cannabis plant material to form an initial mixture;spinning the initial mixture to separate a crude oil and ethanol mixture from the initial mixture;treating the crude oil and ethanol mixture with media to remove unwanted components therefrom;evaporating ethanol from the treated crude oil and ethanol mixture to leave oil;washing the oil with brine;decarboxylating the brine-washed oil to form decarboxylated oil; anddistilling the decarboxylated oil to obtain cannabinoids.2. The process of claim 1 , further comprising the steps of:adding a non-polar solvent to the oil before washing the oil with brine; andevaporating the non-polar solvent after washing the oil with brine.3. The process of claim 2 , wherein the non-polar solvent comprises hexane claim 2 , heptane or pentane.4. The process of claim 2 , further comprising claim 2 , after washing the oil with brine and before evaporating the non-polar solvent claim 2 , drying the oil with magnesium sulfate.5. The process of claim 2 , wherein:the brine is 60-100% saturated with kosher sodium chloride;the step of washing with brine comprises agitating the non-polar solvent, oil and brine for 5-30 minutes; andthe brine ...

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Номер записи: 93
21-04-2016 дата публикации

Process for Producing Phenol and/or Cyclohexanone

Номер: US20160107970A1
Автор: Becker Christopher L., Davis Jason D., Nair Hari, Smith Charles Morris
Принадлежит:

In a process for producing phenol and/or cyclohexanone, cyclohexylbenzene is contacted with an oxygen-containing gas in the presence of an oxidation catalyst under oxidation conditions effective to produce an oxidation effluent comprising cyclohexylbenzene hydroperoxide. At least a portion of the oxidation effluent is then subjected to a concentrating step to produce a cleavage feed having a higher concentration of cyclohexylbenzene hydroperoxide than the oxidation effluent. A cleavage reaction mixture comprising the cleavage feed is then contacted with a solid acid catalyst in a cleavage reaction zone under conditions effective to produce a cleavage product comprising phenol and cyclohexanone. 1. A process for producing phenol , the process comprising:(a) contacting cyclohexylbenzene with an oxygen-containing gas in the presence of an oxidation catalyst under oxidation conditions effective to produce an oxidation effluent comprising cyclohexylbenzene hydroperoxide at a first concentration Con1 and residual cyclohexylbenzene;(b) concentrating at least a portion of the oxidation effluent to produce a cleavage feed comprising cyclohexylbenzene hydroperoxide at a second concentration Con2, where Con2>Con1; and(c) contacting a cleavage reaction mixture formed from the cleavage feed with a solid acid catalyst in a cleavage reaction zone under conditions effective to produce a cleavage product comprising phenol and cyclohexanone.2. The process of claim 1 , wherein the concentrating step (b) comprises distillation to remove at least a portion of the cyclohexylbenzene in the oxidation effluent.3. The process of claim 1 , wherein Con2−Con1>10 wt %.4. The process of claim 1 , wherein Con2−Con1>20 wt %.5. The process of claim 1 , wherein Con1 is in a range from 10 wt % to 30 wt % and Con2 is in a range from 30 wt % to 80 wt %.6. The process of claim 1 , wherein Con1 is in a range from 15 wt % to 25 wt % and Con2 is in a range from 40 wt % to 60 wt %.7. The process of claim 1 , ...

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Номер записи: 94
23-04-2015 дата публикации

Hydroalkylating Process

Номер: US20150112098A1
Автор: Chen Tan-Jen, Green Thomas E., Helton Terry E., Kiss Gabor
Принадлежит:

Disclosed are a catalyst comprising (A) an aluminosilicate molecular sieve comprising a ferrierite phase and (B) a hydrogenation metal component, and a hydroalkylation process using the catalyst. The catalyst and the hydroalkylation process can be used in the production of phenol and/or cyclohexanone from benzene hydroalkylation. 1. A catalyst comprising:(A) an aluminosilicate molecular sieve comprising a ferrierite phase; and(B) a hydrogenation metal component.2. The catalyst of claim 1 , wherein the ferrierite phase has a concentration in a range from 0.001 wt % to 5.0 wt % of the total weight of the molecular sieve.3. The catalyst of claim 1 , wherein the molecular sieve is of the MWW type.4. The catalyst of claim 1 , wherein the molecular sieve exhibits an X-ray diffraction pattern including d-spacing maxima at 12.4±0.25 claim 1 , 6.9±0.15 claim 1 , 3.57±0.07 claim 1 , and 3.42±0.07 Angstrom.5. The catalyst of claim 1 , wherein the molecular sieve exhibits an X-ray diffraction peak 2θ at 9.5±0.5 degrees.6. The catalyst of claim 1 , wherein the hydrogenation metal component is selected from Co claim 1 , Ni claim 1 , Ru claim 1 , Rh claim 1 , Pd claim 1 , Re claim 1 , Os claim 1 , Ir claim 1 , Pt claim 1 , and mixtures and combinations thereof.7. The catalyst of claim 1 , further comprising an inorganic oxide support component.8. The catalyst of claim 7 , wherein the inorganic oxide support component comprises at least one of AlO claim 7 , SiO claim 7 , TiO claim 7 , ZrO claim 7 , and mixtures and combinations thereof.9. The catalyst of claim 7 , wherein the amount of the inorganic oxide support component is in a range from 1 wt % to 30 wt % of the total weight of the catalyst.10. The catalyst of claim 7 , wherein the inorganic oxide support component has an average particle size in a range from 1 μm to 70 μm.11. The catalyst of claim 1 , wherein the amount of the hydrogenation metal component is in a range from 0.01 wt % to 5.0 wt % of the total weight of the ...

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Номер записи: 95
19-04-2018 дата публикации

Concerted processes for forming 1,2,4-trihydroxybenzene from hydroquinone

Номер: US20180105544A1
Автор: Matthew MILLARD, Scott Thomas HUMBARGER
Принадлежит: Lockheed Martin Energy LLC

Flow batteries incorporating an active material with one or more catecholate ligands can have a number of desirable operating features. Commercial syntheses of catechol produce significant quantities of hydroquinone as a byproduct, which presently has limited value in the battery industry and can represent a significant waste disposal issue at industrial production scales. Using a concerted, high-yield process, low-value hydroquinone can be transformed into high-value 1,2,4-trihydroxybenzene, which can be a desirable ligand for active materials of relevance in the flow battery industry. Methods for forming 1,2,4-trihydroxybenzene can include: oxidizing hydroquinone in a first reaction to form p-benzoquinone, converting the p-benzoquinone in a second reaction to form 1,2,4-triacetoxybenzene, deacetylating the 1,2,4-triacetoxybenzene in a third reaction to form 1,2,4-trihydroxybenzene, and isolating the 1,2,4-trihydroxybenzene after performing the first reaction, the second reaction and the third reaction consecutively.

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Номер записи: 96
03-07-2014 дата публикации

Process for Producing Cycloalkylaromatic Compounds

Номер: US20140187821A1
Автор: Becker Christopher L., Chen Tan-Jen, Dakka Jihad M., Lattner James R., Wang Kun, Zushma Stephen
Принадлежит: ExxonMobil Chemical Patents Inc.

In a process for producing a cycloalkylaromatic compound, an aromatic compound and a cyclic olefin are contacted with a first catalyst under conditions effective to produce a reaction product comprising the cycloalkylaromatic compound and at least one non-fused bicyclic by-product. The at least one non-fused bicyclic by-product is then contacted with a second catalyst under conditions effective to convert at least a portion of the at least one non-fused bicyclic by-product to a converted by-product. 1. A process for producing a cycloalkylaromatic compound , the process comprising:(a) contacting an aromatic compound and a cyclic olefin with a first catalyst under conditions effective to produce a reaction product comprising the cycloalkylaromatic compound and at least one non-fused bicyclic by-product; and(b) contacting at least a portion of the at least one non-fused bicyclic by-product and at least a portion of the cycloalkylaromatic compound with a second catalyst under conditions effective to convert at least a portion of the at least one non-fused bicyclic by-product to a converted by-product, and wherein the second catalyst is an acid catalyst.2. The process of claim 1 , wherein the feed to contacting step (b) comprises a weight ratio of the non-fused bicyclic by-product to the cycloalkylaromatic compound of from 1:1000 to 1000:1 as measured at the input to the contacting step (b).3. The process of claim 1 , wherein the contacting step (b) converts at least 50 wt % of the at least one non-fused bicyclic by-product to a converted by-product.4. The process of claim 1 , wherein the reaction product comprises at least 0.01 wt % of the at least one non-fused bicyclic by-product.5. The process of claim 1 , wherein the first catalyst and the second catalyst are different.6. The process of claim 1 , wherein at least 10 wt % of the aromatic compound is supplied to contacting step (a) based on total amount of hydrocarbon supplied to the contacting step (a).7. The process ...

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Номер записи: 97
29-04-2021 дата публикации

PROCESS FOR SYNTHESIZING OF HYDROQUINONE DERIVATIVES WITH HEPTADECATRIENYL SIDE CHAIN

Номер: US20210122690A1
Автор: Lin Kun-Liang, WANG Mei-Hui, WANG PING-YEN
Принадлежит:

Disclosed herein is a process for chemically synthesizing of hydroquinone derivatives, especially for hydroquinone derivatives with heptadecatrienyl side chain, which is synthesized via a Wittig reaction of 2-(10′-oxononyl)-1,4-diacetoxyl benzene and (3E, 5Z)-3,5-heptadien-1-triphenylphosphonium iodide and then deacetylation. In addition, the product is solid powder. 24-. (canceled)5. The method according to claim 1 , wherein the step (a) is carried out by activating 1 claim 1 ,4-dimethoxybenzene with n-butyl lithium in tetrahydrofuran at −78° C. for 1 h and stirring at room temperature for 1 h claim 1 , and then reacting with 1 claim 1 ,10-dibromodecane at room temperature to obtain the compound of formula (1) claim 1 , then the compound of formula (1) is reacted with boron tribromide to demethylate to the compound of formula (2) claim 1 ,and finally, the compound of formula (2) is reacted with acetic anhydride in pyridine at 110° C., 5 h to obtain the compound of formula (3).6. (canceled)7. The method according to claim 1 , wherein the step (e) is carried out by the compound of formula (4) treated with sodium bicarbonate in dimethyl sulfoxide and benzene at 90° C. reflux for 4 h claim 1 , and extracted with 0.1N HCl and saturated sodium chloride claim 1 , after water removal with saturated sodium sulfate claim 1 , obtaining the compound of formula (5).8. (canceled) This application relates to a process for chemically synthesizing of hydroquinone derivatives, especially for hydroquinone derivatives with heptadecatrienyl side chain.An anticancer drug mainly composed of a catechol derivative can inhibit a type II histone deacetylase according to studies, and thus has therapeutic potential for tumors capable of expressing the type II histone deacetylase, and can be used as an anticancer drug for some tumors. However, the current synthesis methods are based on catechol, but catechol is easily oxidized by light and water at room temperature, and has poor long-term ...

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Номер записи: 98
29-04-2021 дата публикации

SILYLATIONS OF AROMATIC SUBSTRATES WITH BASE-ACTIVATED ORGANOSILANES

Номер: US20210122701A1
Автор: Betz Kerry N., FEDEROV ALEXEY, GRUBBS Robert H., TOUTOV ANTON
Принадлежит:

The present disclosure describes methods for silylating aromatic organic substrates, and associated chemical systems, said methods comprising or consisting essentially of contacting the aromatic organic substrate with a mixture of (a) at least one organosilane and (b) at least one strong base, under conditions sufficient to silylate the aromatic substrate. 2. The method of claim 1 , wherein the moiety of formula (I) or (III) is a furan claim 1 , pyrrole claim 1 , thiophene claim 1 , pyrazole claim 1 , imidazole claim 1 , triazole claim 1 , isoxazole claim 1 , oxazole claim 1 , thiazole claim 1 , isothiazole claim 1 , or oxadiazole.9. The method of claim 1 , wherein the at least one strong base comprises the alkali metal alkoxide10. The method of claim 9 , wherein the alkali metal alkoxide comprises a potassium alkoxide or a cesium alkoxide.11. The method of claim 10 , wherein the potassium alkoxide or cesium alkoxide comprises a Clinear or branched alkyl moiety or a Caryl or heteroaryl moiety.12. The method of claim 9 , wherein the alkali metal alkoxide comprises potassium methoxide claim 9 , potassium ethoxide claim 9 , a potassium propoxide or a potassium butoxide.13. The method of claim 9 , wherein the alkali metal alkoxide comprises potassium tert-butoxide.14. The method of claim 1 , wherein the at least one strong base comprises an alkali metal hydride or an alkaline earth metal hydride.15. The method of claim 1 , wherein:(a) the hydrosilane and the at least one strong base are present together at a molar ratio, with respect to one another, in a range of from 20:1 to 1:1; and/or(b) the at least one strong base and organic substrate are present together at a molar ratio, with respect to one another, in a range of from 0.01:1 to 0.9:1.16. The method of claim 1 , wherein m=0.17. The method of claim 1 , wherein m=1 claim 1 , optionally wherein Ris independently tert-butyl claim 1 , —C(CH)(CN) claim 1 , pyridine claim 1 , or an alkyl substituted heterocycloalkyl.18. ...

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Номер записи: 99
30-04-2015 дата публикации

PROCESS FOR PREPARING A PARA-LINEAR ALKYL-SUBSTITUTED HYDROXYAROMATIC COMPOUND

Номер: US20150119308A1
Автор: Campbell Curtis B., Kuperman Alexander E., Mahieux Cedrick
Принадлежит: Chevron Oronite Company LLC

Disclosed herein is a process for preparing an isomeric mixture comprising a major amount of a para-linear mono-alkyl-substituted hydroxyaromatic compound. The process involves the steps of: (a) providing an isomeric mixture comprising a major amount of a para-di(alkyl-substituted)aromatic compound; wherein a first alkyl substituent is a Cto Calkyl moiety and a second alkyl substituent is a Cto Clinear alkyl moiety, wherein n is 0 to 42 and further wherein the second alkyl substituent is at least one carbon atom greater than the first alkyl substituent; (b) subjecting the isomeric mixture comprising a major amount of a para-di(alkyl-substituted)aromatic compound to oxidation conditions in the presence of an oxygen-containing source, thereby converting the first alkyl substituent which is a Cto Calkyl moiety to a hydroperoxide-containing substituted moiety to produce an isomeric mixture comprising a major amount of a para-linear alkyl-substituted, hydroperoxide-containing substituted aromatic compound; and (c) converting the hydroperoxide-containing substituted moiety to a hydroxyl moiety thereby providing an isomeric mixture comprising a major amount of a para-linear mono-alkyl-substituted hydroxyaromatic compound. 1. A process for preparing an isomeric mixture comprising a major amount of a para-linear mono-alkyl-substituted hydroxyaromatic compound , the process comprising the steps of:{'sub': 3', '8', '4+n', '8+n, '(a) providing an isomeric mixture comprising a major amount of a para-di(alkyl-substituted)aromatic compound; wherein a first alkyl substituent is a Cto Calkyl moiety and a second alkyl substituent is a Cto Clinear alkyl moiety, wherein n is 0 to 42 and further wherein the second alkyl substituent is at least one carbon atom greater than the first alkyl substituent;'}{'sub': 3', '8, '(b) subjecting the isomeric mixture comprising a major amount of a para-di(alkyl-substituted)aromatic compound to oxidation conditions in the presence of an oxygen- ...

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Номер записи: 100