СОЕДИНЕНИЯ С АКТИВНОСТЬЮ ЭСТРОГЕННЫХ РЕЦЕПТОРОВ

ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß (19) RU (11) 2006 142 683 (13) A (51) ÌÏÊ C07C 39/42 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÇÀßÂÊÀ ÍÀ ÈÇÎÁÐÅÒÅÍÈÅ (71) Çà âèòåëü(è): ÀÊÝÄÈÀ ÔÀÐÌÀÑÜÞÒÈÊÀËÇ ÈÍÊ. (US) (21), (22) Çà âêà: 2006142683/04, 03.05.2005 (30) Êîíâåíöèîííûé ïðèîðèòåò: 04.05.2004 US 60/568,332 (43) Äàòà ïóáëèêàöèè çà âêè: 10.06.2008 Áþë. ¹ 16 (87) Ïóáëèêàöè PCT: WO 2005/108337 (17.11.2005) Àäðåñ äë ïåðåïèñêè: 103735, Ìîñêâà, óë. Èëüèíêà, 5/2, ÎÎÎ "Ñîþçïàòåíò", ïàò.ïîâ. Ñ.Á.Ôåëèöûíîé, ðåã. ¹ 303 A (54) ÑÎÅÄÈÍÅÍÈß Ñ ÀÊÒÈÂÍÎÑÒÜÞ ÝÑÒÐÎÃÅÍÍÛÕ ÐÅÖÅÏÒÎÐΠ(57) Ôîðìóëà èçîáðåòåíè R U A 2 0 0 6 1 4 2 6 8 3 1. Ñîåäèíåíèå ôîðìóëû (I): (I) èëè åå ôàðìàöåâòè÷åñêè ïðèåìëåìà ñîëü èëè ïðîëåêàðñòâî, ãäå n ïðåäñòàâë åò ñîáîé öåëîå ÷èñëî, âûáðàííîå èç ãðóïïû, ñîñòî ùåé èç 3,4, 5 è 6; R1 âûáðàí èç ãðóïïû, ñîñòî ùåé èç âîäîðîäà, C1-C8 ëèíåéíîãî èëè ðàçâåòâëåííîãî àëêèëà, C1-C8 ëèíåéíîãî èëè ðàçâåòâëåííîãî àëêåíèëà, öèêëîàëêèëà, öèêëîàëêåíèëà, çàìåùåííîãî èëè íåçàìåùåííîãî ãåòåðîàðèëà, çàìåùåííîãî èëè íåçàìåùåííîãî àðèëà, çàìåùåííîãî èëè íåçàìåùåííîãî ãåòåðîàëèöèêëèëà, ñóëüôîíèëà, C1-C 8 ëèíåéíîãî èëè ðàçâåòâëåííîãî ïåðãàëîãåíàëêèëà, -C(=Z)R6, -C(=Z)OR6, è -C(=Z)N(R6)2; R2, R2a, R2b, R2c, ïî îòäåëüíîñòè âûáðàíû èç ãðóïïû, ñîñòî ùåé èç âîäîðîäà, àëêèëà, Ñòðàíèöà: 1 RU 2 0 0 6 1 4 2 6 8 3 (86) Çà âêà PCT: US 2005/015221 (03.05.2005) R U (85) Äàòà ïåðåâîäà çà âêè PCT íà íàöèîíàëüíóþ ôàçó: 04.12.2006 (72) Àâòîð(û): ÎËÑÑÎÍ Ðîäæåð (SE), ÕÈËÄÒÎÔÒ Ëèí (DK), ÏÜÓ Ôàáðèñ (US), ÃÓÑÒÀÔÑÑÎÍ Ìàãíóñ (DK) A 2 0 0 6 1 4 2 6 8 3 A , , R U 2 0 0 6 1 4 2 6 8 3 R U àëêåíèëà, öèêëîàëêèëà, öèêëîàëêåíèëà, çàìåùåííîãî èëè íåçàìåùåííîãî àðèëà, çàìåùåííîãî èëè íåçàìåùåííîãî ãåòåðîàðèëà, çàìåùåííîãî èëè íåçàìåùåííîãî ãåòåðîàëèöèêëèëà, ãèäðîêñè, ãàëîãåíà, ñóëüôîíèëà, ïåðãàëîãåíàëêèëà, -CN, -OR6, -NR6R6a, -NR6NR6aR6b, -NR6N=CR6aR6b, -N(R6)Ñ(R6à)= HR6b, -C(=Z)R6, -C(=Z)OR6, -Ñ(=Z)NR6R6à, -N(R6)-C(=Z)R6a, -N(R6)-C(=Z)NR6bR6a, -OC(=Z)R6, -N(R6)-S(=O)2R6à, è -SR6; êàæäûé R3 ...

Способ получения алкеновых производных или их солей

The invention provides novel compounds of the formula: and wherein m is 1 or 2, R 6 and R 7 , which can be the same or different are H or an alkyl group of 1 to 4 carbon atoms, or wherein n is 0 to 4, R 1 and R 2 , which can be the same or different are H, OH, alkoxy of 1 to 4 carbon atoms, benzyloxy or methoxymethoxy; R 3 is H, OH, halogen, alkoxy of 1 to 4 carbon atoms, benzyloxy, methoxymethoxy, 2,3-dihydroxypropoxy or can form an N-containing three-, four-, five- or six-membered heterocyclic ring; R 4 is OH, F, Cl, Br, I, mesyloxy, tosyloxy, formyloxy, alkylcarbonyloxy of 1 to 4 carbon atoms or CH 2 R 4 is replaced by CHO; R 5 is H or OH; or R 4 and R 5 together form an -0- bridge between the carbon atoms to which they are attached, and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof. Processes for the preparation of these compounds are described, and also novel pharmaceutical compositions containing them. These compounds exhibit valuable pharmacological properties as estrogenic, anti-estrogenic, and progestanic agents. They are also effective against oestrogen-dependent tumours. Certain compounds are useful as chemical intermediates for the preparation of pharmacologically active compounds of the invention.

Improvements in or relating to the manufacture of organic hydroxy compounds and their derivatives

... 523,515. Electrolysis. GLAXO LABORATORIES. Ltd., ROBINSON, F. A., and RESUGGAN, J. C. L. Jan. 10, 1939, No. 835. [Class 41] [Also in Group IV] 4:4<1>-alpha #-tetrahydroxy-alpha #-dialkyldiphenylethanes are made by electrolyte reduction of a 4-hydroxy-phenylalkylketone, e.g., 4-hydroxypropiophenone. The reduction may occur at 35‹ C. in an acid, alkaline, or neutral, aqueous or alcoholic solution. According to the Provisional Specification the ketones may contain one or more aromatic or cycloaliphatic ring and at least one hydroxyl, alkoxy, aroxy aralkoxy or acyloxy group.

PROCEDURE FOR THE PRODUCTION OF 2,3,6,7,10,11 - HEXAHYDROXYTRIPHENYLEN

NEW PROCEDURE FOR the PRODUCTION OF 3-Ä5' (3,4BIS-HYDROXYMETHYL-BENZYLOXY) - 2 ' - ETHYL-2-PROPYLBIPHENYL-4-YLÜ-PENTA-3-OL

4 (1 (PHENYL) - 1 (HYDROXY) - PROP-1-YL) RESORCINDERIVATE, PROCEDURES FOR YOUR PRODUCTION AND THESE CONNECTIONS CONTAINING DRUGS.

META HALOGENPHENOLI ALKYLATING PRODUCTS AND EPOXYSYSTEME.

PROCEDURE FOR the PRODUCTION OF 1,2,3,4TETRAHYDROANTHRACEN-9,10-DIOL.

Method for producing bis(4-hydroxyaryl)alkanes

Novel method for preparing 3-[5'-(3,4-bis-hydroxymethyl-benzyloxy)-2'- ethyl-2-propyl-biphenyl-4-yl]-penta-3-ol

The invention concerns a novel method for preparing 3-[5'-(3,4-bis-hydroxymethyl-benzyloxy)-2'- ethyl-2-propyl-biphenyl-4-yl]-penta-3-ol as well as a novel compound, 6-ethyl-4'-(1-ethyl-1-hydroxy-propyl)-2'-propyl-biphenyl- 3-ol, useful as synthesis intermediate in said method.

1,1,2-TRIPHENYL-ETHANE OR ETHYLENE COMPOUNDS

Novel alkane and alkene derivatives and their non-toxic pharmaceutically acceptable salts are provided herein. The compounds are of the general formula < IMG > (I) or < IMG > (II) wherein n, R1, R2, R3, R4, and R5 are as specifically defined in the specification. The compounds and their non-toxic salts and esters exhibit valuable pharmacological properties as estrogenic, anti-estrogenic, progestanic and anti-tumour activity. Certain compounds of the group are useful as chemical intermediates for the preparation of pharmacologically active compounds of the invention.

1,5-BIS(3S,5S-UDI-HYDROCARBYL-4S-UHYDROXYPHENYL) PENTYL DERIVATIVES

COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND FIBROSIS-RELATED CONDITIONS

The present invention relates to compounds and their use in the prophylactic and/or therapeutic treatment of fibrosis and fibrosis-related conditions, the compounds having the formula:

Procédé de préparation de composés thérapeutiquement actifs

(A) Bis(p-hydroxyaryl)-alkane carboxylic acid derivs. with formula (I) where P is either and R1 hydrogen, lower alkyl or lower alkylen

... (A) Bis(p-hydroxyaryl)-alkane carboxylic acid derivs. with formula (I) where P is either and R1 = hydrogen, lower alkyl or lower alkylene-B-group in which B = basic nitrogen-contng. radical with less than 12C atoms R = hydrogen, hydroxy, nitro, lower alkyl, lower alkoxy, lower alkanoyl, halogen or dialkylamino-lower alkylene group R2 = hydrogen or hydroxy R3 = hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, cycloalkyl, aralkyl, cycloalkyl-lower alkyl, lower alkynyl, aryl, cycloalkyl, aralkyl, cycloalkyl-lower alkyl, thienyl, pyridyl, thienyl-lower alkyl or pyridyl lower alkyl group R2 and R3 together can also represent oxo. R4 = lower alkyl, lower alkynyl, aryl, cycloalkyl, aralkyl, cycloalkyl lower alkyl, thienyl, pyridyl, thienyl-lower alkyl or pyridyl-lower alkyl group. n = 1-5. (B) Acid addition salts of (I) with organic and inorganic acids. The cpds. show therapeutic action, in particular they are hypocholesterolemic.

5-ALKYL- [...][...] EN POSITION [...] DE [...] DE 2.

New hydroxy:phenyl:propenyl substd. naphthalene cpds.

Tetramethyl- tetrahydronaphthyl propenylphenol cpds. of formula (I) are new. where R1= o-, m- or p-hydroxyphenyl; 2,3-, 2,4-, 2,5-, 2,6-, 3,4- or 3,5-dihydroxyphenyl; or 2,3,4-, 2,3,5-, 2,4,5-, 2,4,6-, 3,4,5- or 2,3,6-trihydroxyphenyl. Pref. the olefinic double bond has the trans-configuration.

Radiation-sensitive composition

NOUVEAUX DERIVES DE BIPHENYLE ET LEUR PREPARATION

DERIVES DE BIPHENYLE COMPORTANT DES GROUPEMENTS FORTEMENT REACTIFS. ILS PRESENTENT EN POSITION -2 OU -4 UN GROUPEMENT HYDROXYLE OU ACYLOXY, ET EN POSITION -4 UN GROUPEMENT ACYLE, HYDROXYALKYLE, HYDROXYALKYLENE OU VINYLE. CES COMPOSES SONT INTERESSANTS COMME MATIERES PREMIERES POUR LA PRODUCTION DE POLYMERES RESISTANT A LA CHALEUR ET AUX PRODUITS CHIMIQUES, AINSI QUE COMME PRODUITS INTERMEDIAIRES LORS DE LA SYNTHESE DE MEDICAMENTS, DE COLORANTS ET DE PRODUITS CHIMIQUES POUR L'AGRICULTURE.

NOUVEAUX PHENOLS A SUBSTITUANT HYDROXYALKYLE OU OXOALKYLE ET COMPOSITION PHARMACEUTIQUE LES CONTENANT

L'invention a trait au domaine de la chimie médicale. Elle concerne des composés de l'une des formules ...

NOUVEAU PROCEDE DE PREPARATION DU TETRAHYDRO-1,2,3,4 ANTHRACENE-DIOL-9,10

Procédé pour la préparation du tétrahydro-1,2,3,4 anthracène-diol-9,10 caractérisé en ce que l'on effectue l'hydrogénation catalytique en phase liquide de la tétraydro-1,4,4a,9a anthraquinone en hexahydro-1,2,3,4,4a, 9a anthracène-dione9,10 et l'isomérisation de l'hexahydro-1,2,3,4,4a, 9a anthracènedione-9,10 en tétrahydro-l,2,3,4 anthracène-diol-9,10 en présence d'un acide.

DERIVED FROM THERAPEUTIC RESORCINOL, THEIR PREPARATION AND THEIR USES

Crystal of hexahydroxytriphenylene monohydrate and method for preparation thereof

This invention is to provide a type crystal of 2,3,6,7,10,11-hexahydroxytriphenylene monohydrate, in which an X-ray diffraction spectrum thereof obtained by the use of a copper radiation having = 1.5418 having been passed through a monochrometer has a peak at a lattice distance (d) of 9.0 to 10.1, and it exhibits a thermal decomposition temperature (Td) of approximately 139 DEG C; and a method for preparing the A type crystal of 2,3,6,7,10,11-hexahydroxytriphenylene monohydrate, which comprises holding a solution of 2,3,6,7,10,11-hexahydroxytriphenylene crystals in a acetone-water mixture under a reduced pressure, to thereby distill acetone away from said solution. The above crystal is excellent in thermal stability.

COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS

Disclosed herein are antiviral agents, pharmaceutical formulations comprising effective amounts of these agents and methods for treating mammals suffering from infections caused by viruses. The agents are analogs, isomers, homologs, derivatives and salts of aromatic polycyclic diones.

PROCESS AND COMPOSITION

A method comprising purifying impure bisphenol-A by fractional melt crystallization in a falling film dynamic crystallizer.

Process for preparing monodisperse cation-exchanger gels

The invention relates to a process for preparing monodisperse cation-exchanger gels with increased oxidation resistance and with high osmotic stability and purity by (a) polymerizing monodisperse microencapsulated monomer droplets made from a monomer mixture (1) comprising from 90.5 to 97.99% by weight of styrene, from 2 to 7% by weight of divinylbenzene, and from 0.01 to 2.5% by weight of free-radical generator in aqueous suspension to conversions of from 76 to 100%, (b) adding a monomer mixture (2) made from 70.5 to 95.99% by weight of styrene, from 4 to 15% by weight of divinylbenzene, from 0 to 12% by weight of a third comonomer, and from 0.01 to 2.5% by weight of one or more free-radical generators to form a copolymer, wherein a portion of from 50 to 100% by weight of the monomer mixture (2) is added under polymerization conditions in which at least one free-radical generator from monomer mixture (2) is active, and (c) functionalizing the reaction product from process step (b) by sulfonation ...

Substituted 4'-hydroxy-alpha-ethyl benzhydroles, their use as medicaments and process for their preparation

The invention relates to the preparation of 3-trifluoromethyl- and 2,5-dimethyl-4'-hydroxy- alpha -ethyl-benzhydrol. Both compounds have so far been described only as metabolites of corresponding benzhydrol derivatives containing no hydroxyl group. Neither their physico-chemical characteristics nor their manufacturing processes have been disclosed in the known publications. 3-Trifluoromethyl- and 2,5-dimethyl-4'-hydroxy- alpha -ethyl-benzhydrol are suitable for the treatment of acute ethanolic intoxication. Accordingly, another aspect of the invention is a pharmaceutical composition containing one of these compounds as active ingredient.

Process for preparing 1,2,3,4-tetrahydroanthracen-9,10-diol

СПОСОБ ПОЛУЧЕНИЯ БИС-(4-ГИДРОКСИАРИЛ)АЛКАНОВ

Изобретение относится к выделению бис-(4-гидроксиарил)алканов высокой чистоты из аддуктов бис-(4-гидроксиарил)алканов и ароматических гидроксисоединений. Аддукты получают путем катализируемого кислотой взаимодействия ароматических гидроксисоединений с кетонами. Затем к аддукту в кристаллической форме добавляют в виде аэрозоля водный раствор гидроксида щелочного металла. Исходный водный раствор содержит 0,005-0,015 мас.% гидроксида. Далее аддукт в процессе дистилляции разлагают и отделяют конечный продукт от ароматического гидроксисоединения. Массовый расход гидроксида щелочного металла корректируют по содержанию побочных продуктов в получаемом бис-(4-гидроксиарил)алкане. Предпочтительно получают бисфенол А высокой чистоты из аддукта бисфенола А и фенола. Технический результат - значительное снижение примесей в получаемом высокочистом бис-(4-гидроксиарил)алкане. 5 з.п.ф-лы.

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7 ВУ“” 2017135950"” АЗ Дата публикации: 16.08.2019 Форма № 18 ИЗ,ПМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2017135950/04(06269Т) 18.03.2016 РСТ/АЧ2016/000095 18.03.2016 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 2015900979 18.03.2015 АО Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) Композиции для лечения фиброза и связанных с фиброзом состояний Заявитель: ВЕКТУС БАЙОСИСТЕМС ЛИМИТЕД, АЧ 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. П см. Примечания [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) С07С 39/15 (2006.01) С07О 207/408 (2006.01) Аб1К 31/165 (2006.01) С07С 47/575 (2006.01) С07О 207/448 (2006.01) Аб/1К 31/192 (2006.01) С07С 65/03 (2006.01) С07О 209/48 (2006.01) Аб1К 31/381 (2006.01) С07С 211/29 (2006.01) (070 233/78 (2006.01) Аб/1К 31/42 (2006.01) С07С 217/48 (2006.01) (070 261/14 (2006.01) Аб1Р 1/12 (2006.01) С07О 207/267 (2006.01) (070 263/42 (2006.01) Аб1Р 9/10 (2006.01) С07О 207/36 (2006.01) (070 263/44 (2006.01) Аб1Р 13/12 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) С07С ...

ZUSAMMENSETZUNG UND VERFAHREN ZUR BEHANDLUNG VIRALER INFEKTIONEN

Liquid crystalline optionally laterally fluorinated terphenyl with chiral 3,4-di[(un)saturated-alkoxy]butoxy or 1,4-di[(un)saturated-alkoxy]but-2-oxy terminus

The invention relates to terphenyl compounds having the general formula [1]:- where each of R1 and R2 is the same or different and is selected from the group consisting of:-alkyl, alkyloxy, alkylthio, alkenyl, alkenyloxy, alkenylthio, alkynyl, alkynyloxy, alkynylthio, where * indicates an asymmetric carbon atom,
provided that at least one of R1 and R2 is and where each of R3 and R4 is the same or different and is an alkyl, alkenyl or alkynyl group; and Z is independently selected from hydrogen and fluorine at each of the four lateral terphenyl carbons in each ring. The compounds are suitable for use in liquid crystal compositions.

HYDROGENATION CATALYST, PROCEDURE FOR THE PRODUCTION OF THIS CATALYST AND ITS USE WITH THE PRODUCTION OF HYDROGEN PEROXIDE

META-HALO-PHENOLIC ALKYLATION PRODUCTS AND EPOXY SYSTEMS

ABSTRACT The invention concerns a coupled aromatic compound represented by the formula Ar-Y I wherein Ar is an aromatic moiety different from Y and Y is an aromatic moiety represented by one of the formulae: 35,166-F II, III, IV, V, VI or VII wherein A is an aliphatic ring system bonded to the aromatic ring; Q is separately at each occurrence hydrogen, alkyl or inertly-substituted alkyl with proviso that the carbon atom bonded to the aromatic ring is a primary or secondary carbon atom. X is separately at each occurrence a halogen moiety, Z is a nitrogen- or chalcogen-containing moiety, and their preparation. The materials contain a 35,166-F moiety such as, for example, 4-oxy-3,5-dimethyl-2,6-dibromobenzyl which can impart a high degree of thermal and hydrolytic stability to the materials, for example, epoxy thermosets such as in electronic encapsulations. For example, when used in electronic encapsulation formulations, these materials can provide a substantial increase in electronic device reliability. Their preparation involves an alkylation of an aromatic ring, for example, such as a Friedel-Crafts alkylation with 4-bromomethyl-3,5-dibromo-2,6-dimethylphenol or with 4-hydroxymethyl-3,5-dibromo-2,6-dimethylphenol. 35,166-F

2-SUBSTITUTED-5-ALKYL RESORCINOLS

Covers 2-substituted-5-alkyl resoreinols represented by the formula wherein R1 is hydrogen or lower-alkanoyl; R2 is a straight or branched chain alkyl of 1 to 20 carbon atoms; and X is nitrogen or C-methyl. The compound of this invention are useful as tranquilizers, analgesics, sedative-hypnotics and anticonvulsants.

3-TRIFLUOROMETHYL-AND 2,5-DIMETHYL-4'-HYDROXY-.alpha.- ETHYL-BENZHYDROL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

NOVEL METHOD FOR PREPARING 3-[5'-(3,4-BIS-HYDROXYMETHYL-BENZYLOXY)-2'- ETHYL-2-PROPYL-BIPHENYL-4-YL]-PENTA-3-OL

La présente invention se rapporte à un nouveau procédé de fabrication du 3-[5'- (3,4-bis-hydroxymethyl-benzyloxy)-2'-ethyl-2-propyl-biphenyl-4-yl]-penta-3-ol ainsi qu'à un composé nouveau, le 6-éthyl-4'-(1-éthyl-1-hydroxy-propyl)-2'- propyl-biphenyl- 3-ol, utile comme intermédiaire de synthèse dans ledit procédé.

COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS

Disclosed herein are antiviral agents, pharmaceutical formulations comprising effective amounts of these agents and methods for treating mammals suffering from infections caused by viruses. The agents are analogs, isomers, homologs, derivatives and salts of aromatic polycyclic diones.

COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS

Disclosed herein are anitiviral agents, pharmaceutical formulations comprising effective amounts of these agents and methods for treating mammals suffering from infections caused by viruses. The agents are analogs, isomers, homologs, derivatives and salts of aromatic polycyclic diones.

Cyclopolyarylene compound and method of manufacturing same

This cyclopolyarylene compound is represented by general formula (1): (In the formula, each k is the same or different, and each represents 0, 1 or 2; each m is the same or different, and each represents 1, 2 or 3; and n represents 3, 4, 5 or 6.) ...

For the hard mask film composition of the monomer in the monomer composition including the hard mask using the same and method for forming pattern

NEW BIPHENYL DERIVATIVES AND THEIR PREPARATION

Production of a new dihydroxypyrene

NEW METHOD OF PREPARATION OF TETRAHYDRO-1,2,3,4 ANTHRACENE-DIOL-9,10

4-oxypyrene and its method of preparation

NOVEL BIPHENYL DERIVATIVES AND THEIR PREPARATION

DERIVES DE BIPHENYLE COMPORTANT DES GROUPEMENTS FORTEMENT REACTIFS. ILS PRESENTENT EN POSITION -2 OU -4 UN GROUPEMENT HYDROXYLE OU ACYLOXY, ET EN POSITION -4 UN GROUPEMENT ACYLE, HYDROXYALKYLE, HYDROXYALKYLENE OU VINYLE. CES COMPOSES SONT INTERESSANTS COMME MATIERES PREMIERES POUR LA PRODUCTION DE POLYMERES RESISTANT A LA CHALEUR ET AUX PRODUITS CHIMIQUES, AINSI QUE COMME PRODUITS INTERMEDIAIRES LORS DE LA SYNTHESE DE MEDICAMENTS, DE COLORANTS ET DE PRODUITS CHIMIQUES POUR L'AGRICULTURE. BIPHENYL DERIVATIVES CONTAINING STRONGLY REACTIVE GROUPS. THEY PRESENT IN POSITION -2 OR -4 A HYDROXYL OR ACYLOXY GROUP, AND IN POSITION -4 AN ACYL, HYDROXYALKYL, HYDROXYALKYLENE OR VINYL GROUP. THESE COMPOUNDS ARE OF INTEREST AS RAW MATERIALS FOR THE PRODUCTION OF HEAT AND CHEMICAL RESISTANT POLYMERS, AS WELL AS INTERMEDIATE PRODUCTS IN THE SYNTHESIS OF DRUGS, COLORANTS AND CHEMICALS FOR AGRICULTURE.

preparation of 3 - process [5 '- (3.4 bis-hydroxymethyl-benzyloxy) - 2'-ethyl-2-propyl-steak Nil silk it 4 it [...] penta it 3 ol, compound, process of preparing and using 6-ethyl-4 '- (1-ethyl-1-hydroxy-propyl) - 2'-propyl-biphenyl-3 ol

RADIATION-SENSITIVE COMPOSITION

Disclosed is a radiation-sensitive composition containing a resist compound which enables to obtain a resist pattern with a good shape, while having high sensitivity, high resolution, high etching resistance and low outgas. Also disclosed are a resist pattern-forming method using such a radiation-sensitive composition; a composition for forming a novel photoresist foundation layer which is excellent in optical characteristics and etching resistance, while having substantially no sublimation product; and a foundation layer made of such a composition. Specifically disclosed is a radiation-sensitive composition containing a cyclic compound having a specific structure, namely a cyclic compound (A) having a molecular weight of 700-5000 which is synthesized by a condensation reaction between a compound having 1-4 formyl groups and 2-59 carbon atoms (an aldehydic compound (A1)) and a compound having 1-3 phenolic hydroxy groups and 6-15 carbon atoms (a phenolic compound (A2)), and a solvent. Also ...

PREPARATION OF 1,2-BIS(4-HYDROXYPHENYL)-2-HYDROXYPROPANES

The present invention relates to the preparation of substituted or unsubstituted 1,2-bis(4-hydroxyphenyl)-hydroxyaliphatics such as 1,2-bis(4-hydroxyphenyl)-2-hydroxypropanes by reacting substituted or unsubstituted 1,2-bis(4-hydroxyphenyl)-halogen substituted aliphatics such as 1,2-bis(4-hydroxyphenyl)-2-chloropropanes in the presence of a base and water.

PHENOLIC EPOXY COMPOUNDS

Disclosed herein are compositions and methods of making phenolic compounds, and resins comprising these phenolic compounds. The compounds include multifunctional epoxies, amino glycidyl derivatives, and multi-functional amines prepared from hydroxymethyl derivatives of phenols and bisphenols ...

Material for forming underlayer film for lithography, composition for forming underlayer film for lithography, underlayer film for lithography and production method thereof, pattern forming method, resin, and purification method

The present embodiment provides a material for forming an underlayer film for lithography, containing at least any of a compound represented by following formula (1) or a resin including a structural unit derived from a compound represented by the following formula (1),wherein R1 represents a 2n-valent group having 1 to 60 carbon atoms, or a single bond, each R2 independently represents a halogen atom, a straight, branched or cyclic alkyl group having 1 to 10 carbon atoms, an aryl group having 6 to 10 carbon atoms, an alkenyl group having 2 to 10 carbon atoms, an alkoxy group having 1 to 30 carbon atoms, a thiol group, a hydroxyl group, or a group where a hydrogen atom of a hydroxyl group is substituted with an acid-dissociable group, and may be the same or different in the same naphthalene ring or benzene ring, in which at least one R2 represents a group where a hydrogen atom of a hydroxyl group is substituted with an acid-dissociable group, n is an integer of 1 to 4, and structural formulae ...

НОВЫЙ СПОСОБ ПОЛУЧЕНИЯ 3-[5'-(3,4-БИС-ГИДРОКСИМЕТИЛБЕНЗИЛОКСИ)-2'-ЭТИЛ-2-ПРОПИЛБИФЕНИЛ-4-ИЛ]-ПЕНТА-3-ОЛА

Настоящее изобретение относится к способу получения 3-[5'-(3,4-бис-гидроксиметилбензилокси)-2'-этил-2-пропилбифенил-4-ил]пента-3-ола, который может быть использован в медицине. Способ включает: превращение 1-(4-гидрокси-3-пропилфенил)пропан-1-она под действием трифторметансульфонового ангидрида (Tf2O) в присутствии триэтиламина (NEt3) в его производное 4-пропионил-2-н-пропилфениловый эфир трифторметансульфоновой кислоты, с последующей конденсацией по типу реакции Suzuki с 2-этил-5-метоксифенилбороновой кислотой в присутствии К2СО3, каталитического количества РdСl2(РРh3)2 или Рd(РРh3)4, с получением 1-(2'-этил-5'-метокси-2-пропилбифенил-4-ил)пропан-1-она; деметилирование 1-(2'-этил-5'-метокси-2-пропилбифенил-4-ил)пропан-1-она нагреванием в отсутствие растворителя с избытком пиридиновых солей, с получением 1-(2'-этил-5'-гидрокси-2-пропилбифенил-4-ил)пропан-1-она; превращение 1-(2'-этил-5'-гидрокси-2-пропилбифенил-4-ил)пропан-1-она в 6-этил-4'-(1-этил-1-гидроксипропил)-2'-пропилбифенил-3-ол ...

NEUES VERFAHREN ZUR HERSTELLUNG VON 3-Ä5'-(3,4-BIS-HYDROXYMETHYL-BENZYLOXY)-2'- ETHYL-2-PROPYL-BIPHENYL-4-YLÜ-PENTA-3-OL

Improvements in the manufacture of anthranol

Anthranol is prepared by reducing anthaquinone with caustic alkali and a carbohydrate such as glucose, cane sugar, molasses, maltose, or lactose.

Bicyclic derivatives of hydroquinone

... 1,141,307. Substituted hydroquinones. EASTMAN KODAK CO. 6 May, 1966 [10 May, 1965], No. 20012/66. Heading C2C. A 1,4 - bridged - 5,8 - dihydroxy - 1,2,3,4 - tetrahydronaphthalene is prepared by reacting the corresponding 1,4 - bridged - 1,4,4a,8a - tetrahydro - 5,8 - naphthoquinone with a mixture of a mineral acid, acetic or propionic acid, and acetic or propionic anhydride to form the corresponding 1,4 - bridged - 5,8 - diacyloxy - 1,4 - dihydronaphthalene, hydrogenating this compound to the corresponding 1,2,3,4 - tetrahydronaphthalene and converting the acyloxy groups at the 5- and 8- positions to hydroxy groups by hydrolysis or ester interchange.

SUBSTITUTED 4 ' - HYDROXY ALPHA AETHYLBENZHYDROLE ONES FOR USE AS ARNZEIMITTEL.

COMPOSITION AND PROCEDURE FOR THE TREATMENT VIRALER INFECTIONS

1,3-DIPHENYLPROPANDERIVATE WITH RESTRAINING ACTIVITY AGAINST TYROSINASE AND PROCEDURES FOR THEIR PRODUCTION

2,3-BIS-HYDROXY BENZYL-1,4-BUTANDIOLS AND THEIR ETHER AND ESTHER DERIVATIVES

1,2,3,4-TETRAHYDRO-9,10-ANTHRACENE-DIOL

1,5-BIS%3@,5@-DI-HYDROCARBYL-4@-HYDROXYPHENYL< PENTYL DERIVATIVES

TRI-PHENYL ALKANES ALKENES

3-TRIFLUOROMETHYL-AND 2,5-DIMETHYL-4'-HYDROXY-.alpha.- ETHYL-BENZHYDROL DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

The invention relates to the preparation of 3-trifluoromethyl- and 2,5-dimethyl-4'-hydroxy-?-ethyl-benzhydrol. Both compounds have so far been described only as metabolites of corresponding benzhydrol derivatives containing no hydroxyl group. Neither their physico-chemical characteristics nor their manufacturing processes have been disclosed in the known publications. 3-Trifluoromethyl- and 2,5-dimethyl-4'-hydroxy-?-ethyl-benzhydrol are suitable for the treatment of acute ethanolic intoxication. Accordingly, another aspect of the invention is a pharmaceutical composition containing one of these compounds as active ingredient.

DERIVED 1,5-(A) (3 ', 5 ' - DI-HYDROCARBYL-4'-HYDROXYPHENYL) PENTYLE

Process for the preparation of derivatives bicyclic of hydroquinone

Manufacture of polyols starting from 2-hydroxyméthyl-1, 3-dioxolane and of phenolic compounds

MONOMER FOR HARDMASK COMPOSITION, HARDMASK COMPOSITION COMPRISING MONOMER, AND METHOD FOR FORMING PATTERN USING HARDMASK COMPOSITION

The present invention relates to a monomer for a hardmask composition, a hardmask composition comprising the monomer, and to a method for forming a pattern using the same. In chemical formula 1, the definitions of A, A′, L, X, X′, X″, k, m and n are the same as defined in the specification. COPYRIGHT KIPO 2016 ...

MATERIAL FOR FORMING FILM FOR LITHOGRAPHY, COMPOSITION FOR FORMING FILM FOR LITHOGRAPHY, FILM FOR LITHOGRAPHY, PATTERN FORMING METHOD AND PURIFICATION METHOD

The material for forming a film for lithography according to the present invention contains a compound represented by the following formula (1): 2. The material for forming the film for lithography according to claim 1 , wherein at least one p is an integer of 1 to 4.3. The material for forming the film for lithography according to claim 1 , wherein at least one Rrepresents the monovalent group having the oxygen atom.7. The resin according to claim 6 , wherein at least one p is an integer of 1 to 4.8. The resin according to claim 6 , wherein at least one Rrepresents the monovalent group having the oxygen atom.9. The resin according to claim 6 , wherein the compound having crosslinking reactivity is an aldehyde claim 6 , a ketone claim 6 , a carboxylic acid claim 6 , a carboxylic acid halide claim 6 , a halogen-containing compound claim 6 , an amino compound claim 6 , an imino compound claim 6 , an isocyanate claim 6 , or an unsaturated hydrocarbon group-containing compound.10. The resin according to claim 6 , which is at least one selected from the group consisting of a novolac-based resin claim 6 , an aralkyl-based resin claim 6 , a hydroxystyrene-based resin claim 6 , a (meth)acrylic acid-based resin and copolymers thereof.13. A material for forming a film for lithography claim 6 , comprising the resin according to .14. A composition for forming a film for lithography claim 6 , comprising{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'the material for forming the film for lithography according to , and'}an organic solvent.15. The composition for forming the film for lithography according to claim 14 , further comprising an acid generating agent.16. The composition for forming the film for lithography according to claim 14 , further comprising a crosslinking agent.17. A film for lithography claim 14 , formed using the composition for forming the film for lithography according to .18. A resist pattern forming method claim 14 , comprising{'claim-ref': {'@idref': ' ...

Композиции для лечения фиброза и связанных с фиброзом состояний

FIELD: chemistry.SUBSTANCE: present invention relates to a novel compound of formula:or to its pharmacologically acceptable salt. In said structural formulas A is selected from: partially saturated or unsaturated 5- or 6-member heterocyclyl selected from pyrrolyl, pyrazolyl, imidazolyl, triazolyl, imidazolidinyl, pyrrolidinyl, pyrrolidinylidene, dihydropyrrolyl, isoxazolyl-dihydrooxazolyl, isoxazolidinyl, oxazolidinyl and oxazolyl, where said partially saturated or unsaturated 5- or 6-member heterocyclyl is optionally substituted with one or more oxo, Calkyl, amino, hydroxyl or halogen; Calkoxylamine; Calkylamine, optionally substituted with one or more substitutes, which are Calkyl, Chaloalkyl, hydroxyl or halogen; Calkyl-carboxylic acid; Calkylhydroxyl; saturated or unsaturated Calkyl-bicyclic-heterocyclyl, selected from indolyl, isoindolyl, indolinyl and isoindolinyl, where said saturated or unsaturated Calkyl-bicyclic-heterocyclyl is optionally substituted with one or more oxo; and saturated or unsaturated Calkoxy-bicyclic-heterocyclyl, selected from indolyl, isoindolyl, indolinyl and isoindolinyl, where said Calkoxy-bicyclic-heterocyclyl is optionally substituted with one or more oxo.EFFECT: compound is used for preventive or therapeutic treatment of fibrosis.27 cl, 22 dwg, 15 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК C07C 39/15 (2006.01) C07C 47/575 (2006.01) C07C 65/03 (2006.01) C07C 211/29 (2006.01) C07C 217/48 (2006.01) C07D 207/267 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА C07D 207/36 (2006.01) ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ C07D 207/408 (2006.01) C07D 207/448 (2006.01) C07D 209/48 (2006.01) (12) (13) 2 712 140 C2 C07D 233/78 (2006.01) C07D 261/14 (2006.01) C07D 263/42 (2006.01) C07D 263/44 (2006.01) A61K 31/165 (2006.01) A61K 31/192 (2006.01) A61K 31/381 (2006.01) A61K 31/42 (2006.01) A61P 1/12 (2006.01) (см. продолжение) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК (21)(22) Заявка: 2017135950, 18.03.2016 18.03.2016 (73) Патентообладатель(и): ВЕКТУС БАЙОСИСТЕМС ...

Композиции для лечения фиброза и связанных с фиброзом состояний

PROCESS FOR PREPARING 1,2,3,4-TETRAHYDROANTHRACEN-9,10-DIOL

Terphenylverbindungen

Hydroxymethyl-substituierte polyfunktionelle Phenole

Optisch aktive Benzol-Derivate, Verfahren zu ihrer Herstellung und flüssigkristalline Zusammensetzung, welche solche Derivate als flüssigkristalline Verbindung enthält und Licht-Ausschaltelemente

"13C-labelled synthesis"

NEW BIPHENYL COMPOUNDS AND PROCESS FOR PRODUCING THE SAME

Derivatives of Bis(p-Hydroxyaryl Alkanoic Acids

... 1,193,686. Bis(substituted - phenyl) - compounds. E. R. SQUIBB & SONS Inc. 25 April, 1967, No. 19047/67. Heading C2C. Novel compounds of the Formula I and acid addition salts thereof wherein P represents one of the radicals of the formulµ wherein R represents hydrogen, hydroxy, nitro, lower alkyl, lower alkoxy, lower alkanoyl, halo or dialkylamino-lower alkylene, R1 represents hydrogen or lower alkyl, R2 represents hydrogen or hydroxy and R3 represents hydrogen, lower alkyl, lower alkenyl, lower alkynyl, aryl, cycloalkyl, aralkyl, cycloalkyl-lower alkyl, thienyl, pyridyl, thienyl-lower alkyl or pyridyl - lower alkyl or R2 and R3 together represent oxo, R4 represents lower alkynyl, aryl, cycloalkyl, aralkyl, cyoloalkyl-lower alkyl, thienyl, pyridyl, thienyl-lower alkyl or pyridyl-lower alkyl, and n is an integer from 1 to 5 (lower means 1 to 8 carbon atoms); (a) the preparation of a compound I (R, R1 and R2 have the ...

CALIXAREN DERIVATIVES WITH ANTIVIRAL EFFECT

PROCESS FOR PREPARING 1,2,3,4 TETRAHYDRO 9.10 DIOL-ANTHRACENE

Procédé pour la préparation du tétrahydro-1,2,3,4 anthracène-diol-9,10 caractérisé en ce que l'on effectue l'hydrogénation catalytique en phase liquide de la tétrahydro-1,4,4a, 9a anthraquinone en hexahydro-1,2,3,4,4a 9a anthracène-dione-9,10 et l'isomérisation de l'hexahydro-1,2, 3,4,4a 9a anthracène-dione-9,10 en tétrahydro-1,2,3,4 anthracène-diol-9,10 en présence d'un acide. Ce procédé donne de bons rendements, il fait appel à une matière première peu coûteuse et facilement accessible.

UROLITHIN A AND DERIVATIVES THEREOF FOR USE IN THERAPY

In some embodiments of the invention, inventive compounds (e.g., Formula (I), (IA), (II), and (III), and urolithin derivatives) are disclosed. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein.

1,1,2-TRIPHENYL-ETHANE OR ETHYLENE COMPOUNDS

NEW PHENOLS HAS SUBSTITUENT HYDROXYALKYLE OR OXOALKYLE AND PHARMACEUTICAL COMPOSITION THE CONTAINER

New derivatives of pyrene and process for their obtaining

NEW METHOD OF PREPARATION OF the 3 (5 ' - (3,4-BISHYDROXYMETHYL-BENZYLOXY) - 2 ' - ETHYL-2-PROPYL-BIPHENYL-4-YL) - PENTA-3OL

La présente invention se rapporte à un nouveau procédé de fabrication du 3-[5'-(3,4-bis-hydroxymethyl-benzyloxy)-2'-ethyl-2-propyl-biphenyl-4-yl]-penta-3ol ainsi qu'à un composé nouveau, le 6-éthyl-4'-(1-éthyl-1-hydroxy-propyl)-2'-propyl-biphenyl-3-ol, utile comme intermédiaire de synthèse dans ledit procédé.

Substituted phenols and their methods of preparation

(A) Bis(p-hydroxyaryl)-alkane carboxylic acid derivs. with formula (I) where P is either and R1 hydrogen, lower alkyl or lower alkylen

1,3-Benzo:dioxin-2-carboxylic acid derivs. - useful for treating hyperlipidaemia, cardiac insufficiency and angina

RESIST UNDERLAYER FILM COMPOSITION, PATTERNING PROCESS, AND COMPOUND

[과제] 매립 특성이 우수하고, 아웃 가스의 발생이 적으면서, 또한 내열성이 높은 레지스트 하층막 재료를 제공한다. [해결수단] 리소그래피에서 이용되는 레지스트 하층막 재료로서, 인데노플루오렌 구조를 갖는 화합물을 함유하는 것임을 특징으로 하는 레지스트 하층막 재료.

METHOD FOR PREPARING HYDROXY COMPOUND

The present invention relates to a process for preparing a hydroxy polycarboxylic aromatic compound, and more particularly, to a process for producing a hydroxycarboxylic aromatic compound, The present invention relates to a method for producing a hydroxy compound in a high purity by a mild and simple process without complicated and dangerous process.

Способ получения 1,2,3,4-тетрагидроантрацендиола-9,10/его варианты/

Hydrierungskatalysator, Verfahren zur Herstellung dieses Katalysators und seine Verwendung bei der Herstellung von Wasserstoffperoxid

NEUE 2-FLUORETHOXY-SUBST.-BENZOLDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND INSEKTIZIDE UND AKARIZIDE MITTEL, DIE DIESE NEUEN DERIVATE ALS WIRKSTOFFE ENTHALTEN

Verfahren zur Modifizierung von filmbildenden OElen und Harzmaterialien und zum Modifizieren und Haerten von Epoxyharzen

Acaricidal and insecticidal 2-fluoroethoxy-substituted benzene derivatives

A 2-fluoroethoxy-substituted benzene derivative represented by the general formula (I) wherein X represents an oxygen or sulfur atom, R1 and R2 represent a hydrogen atom or a lower alkyl group, n represents 0 or 1, and A represents a group of the general formula (II) in which R3 and R4 represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, a lower alkylthio group, a lower haloalkyl group, a lower haloalkylthio group or a methylenedioxy group, R5 and R6 represent a hydrogen atom or a lower alkyl group, and p and m represent 0 or 1. This compound is useful as an active ingredient of insecticidal and acaricidal agents, and can be produced by reacting a compound of the general formula (III) with a compound of the general formula A-D (IV) wherein in general formulae (III) and (IV), A, R1, R2 and n are as defined above, and one of B and D represents a a halogen atom and the other represents a group of the general formula -X-M in which X is as defined above, and ...

1,5-BIS%3@,5@-DI-HYDROCARBYL-4@-HYDROXYPHENYL< PENTYL DERIVATIVES

COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS

SELECTED BLOCK PHENOLIC OLIGOMERS AND THEIR USE IN PHENOLIC RESIN COMPOSITIONS AND IN RADIATION-SENSITIVE RESIST COMPOSITIONS

1,5-BIS(3S,5S-UDI-HYDROCARBYL-4S-UHYDROXYPHENYL) PENTYL DERIVATIVES

Method of preparation of derived from acids (a) (p-hydroxyaryl) alcanoïques

DERIVED FROM THERAPEUTIC RESORCINOL, THEIR PREPARATION AND THEIR USES

Process to prepare treprostinil, the active ingredient in remodulin®

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.

CYCLOPOLYARYLENE COMPOUND AND METHOD OF MANUFACTURING SAME

A cyclopolyarylene compound represented by Formula (1): 2. The cyclopolyarylene compound according to claim 1 , wherein all k are the same; and all m are the same in Formula (1).3. The cyclopolyarylene compound according to claim 1 , wherein all k are 0 or 1; all m are 1 or 2; and n is 3 or 4 in Formula (1).5. The compound according to claim 4 , wherein all R are the same; all k are the same; and all m are the same in Formula (2). The present invention relates to a cyclopolyarylene compound and a production method thereof.Hitherto-known nanostructures containing carbon atoms include carbon nanotubes made of a cylindrically rolled two-dimensional graphene sheet.Carbon nanotubes have high electrical conductivity, high mechanical strength, superior elasticity, heat resistance, and are lightweight. With these advantageous properties, carbon nanotubes are expected to be applied to various fields, including chemistry, electronics, and life science.Carbon nanotubes can be produced through arc discharge, laser furnaces, chemical vapor deposition, and the like. However, these methods have a disadvantage in that they can only produce mixtures of carbon nanotubes of various lengths and diameters.Recent studies reported research on a cycloparaphenylene compound, which is the smallest unit for making a carbon nanotube. shows an example of a structure of a cycloparaphenylene compound.For example, Non-Patent Document 1 discloses a method for producing a cycloparaphenylene compound as a mixture having a cyclic structure composed of 9, 12, or 18 continuously bonded benzene rings, using 1,4-diiodobenzene and benzoquinone as materials.Non-Patent Documents 2 and 3 disclose a method for producing a cycloparaphenylene compound having a cyclic structure in which 12 benzene rings are regularly bonded, using 1,4-cyclohexanedione and 1,4-diiodobenzene.Non-Patent Document 4 discloses a method for producing a cycloparaphenylene compound in which 8 benzene rings are regularly bonded through ...

Monomer for hardmask composition and hardmask composition including the monomer and method of forming patterns using the hardmask composition

A monomer for a hardmask composition is represented by the following Chemical Formula 1,

1-PHENYL-2-PHENYLETHANE DERIVATIVE

Provided is a novel compound having a selective activating effect on ERβ. The present invention provides a compound represented by the following formula (1) wherein Rrepresents a cycloalkyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 6 carbon atoms and optionally substituted with a halogen atom, a 5-membered nitrogen-containing heteroaryl group, a 4- to 6-membered cyclic amino group, an alkanoylamino group having 2 to 6 carbon atoms and optionally substituted with a halogen atom, a 1-trifluoromethyl-1-hydroxymethyl group, or a 1-methylpropyl group; Rto Rare the same or different and each represent a hydrogen atom or a fluorine atom; and Rrepresents a hydrogen atom or an alkanoyl group having 2 to 5 carbon atoms, or a salt thereof. 2: An ERβ activating agent comprising the compound represented by the formula (1) or the salt thereof according to as an active ingredient.3: A skin aging preventing or ameliorating agent comprising the compound represented by the formula (1) or the salt thereof according to as an active ingredient.4: A sebum secretion inhibiting agent comprising the compound represented by the formula (1) or the salt thereof according to as an active ingredient.5: An acne preventing or ameliorating agent comprising the compound represented by the formula (1) or the salt thereof according to as an active ingredient.6: A hot flash preventing or ameliorating agent comprising the compound represented by the formula (1) or the salt thereof according to as an active ingredient.7: A prostatic hyperplasia preventing or ameliorating agent comprising the compound represented by the formula (1) or the salt thereof according to as an active ingredient.8: An androgen activation inhibiting agent comprising the compound represented by the formula (1) or the salt thereof according to as an active ingredient.932-. (canceled) The present invention relates to a compound having high selectivity for estrogen receptor 0.Estrogen, also called follicle hormone ...

PHENOLIC EPOXY COMPOUNDS

Disclosed herein are compositions and methods of making phenolic compounds, and resins comprising these phenolic compounds. The compounds include multifunctional epoxies, amino glycidyl derivatives, and multi-functional amines prepared from hydroxymethyl derivatives of phenols and bisphenols. 25-. (canceled)6. The compound of claim 1 , wherein:{'sub': '1', 'Ris H or Z;'}{'sub': 2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris —N(Z), —N(CH—O—Z), —N(CHCH—O—Z), —N(CHOH), —N(CHNH), or —N(CHCHOH);'}{'sub': 3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris —N(Z), —N(CH—O—Z), —N(CHCH—O—Z), —N(CHOH), —N(CHNH), or —N(CHCHOH); and'}{'sub': 4', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris —N(Z), —N(CH—O—Z), —N(CHCH—O—Z), —N(CHOH), —N(CHNH), or —N(CHCHOH).'}7. The compound of claim 1 , wherein:{'sub': '1', 'Ris Z;'}{'sub': 2', '2', '2', '2', '2', '2', '2, 'Ris —N(Z), —N(CH—O—Z), or —N(CHCH—O—Z);'}{'sub': 3', '2', '2', '2', '2', '2', '2, 'Ris —N(Z), —N(CH—O—Z), or —N(CHCH—O—Z); and'}{'sub': 4', '2', '2', '2', '2', '2', '2, 'Ris —N(Z), —N(CH—O—Z), or —N(CHCH—O—Z).'}8. The compound of claim 1 , wherein Ris Z claim 1 , Ris —N(Z) claim 1 , Ris —N(Z)and Ris —N(Z).9. The compound of claim 1 , wherein Ris Z claim 1 , and each of Ris —N(CH—O—Z) claim 1 , Ris{'sub': 2', '2', '4', '2', '2, '—N(CH—O—Z)and Ris —N(CH—O—Z).'}10. The compound of claim 1 , wherein Ris Z claim 1 , and each of Ris —N(CHCH—O—Z) claim 1 , Ris{'sub': 2', '2', '2', '4', '2', '2', '2, '—N(CHCH—O—Z)and Ris —N(CHCH—O—Z).'}11. The compound of claim 1 , wherein:{'sub': '1', 'Ris H;'}{'sub': 2', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris —N(CHOH), —N(CHNH), or —N(CHCHOH);'}{'sub': 3', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris —N(CHOH), —N(CHNH), or —N(CHCHOH); and'}{'sub': 4', '2', '2', '2', '2', '2', '2', '2', '2, 'Ris —N(CHOH), —N(CHNH), or —N(CHCHOH).'}12. The compound of claim 1 , wherein Ris H claim 1 , Ris —N(CHOH) claim 1 , Ris ...

COMPOUND, RESIN, COMPOSITION, RESIST PATTERN FORMATION METHOD AND CIRCUIT PATTERN FORMATION METHOD

The present invention provides a compound having a specific structure represented by the following formula (0), a resin having a constituent unit derived from the compound, various compositions containing the compound and/or the resin, and various methods using the compositions. 7. A resin having a unit structure derived from the compound according to .10. A composition comprising one or more selected from the group consisting of the compound according to and a resin having a unit structure derived from the compound.11. The composition according to claim 10 , further comprising a solvent.12. The composition according to claim 10 , further comprising an acid generating agent.13. The composition according to claim 10 , further comprising an acid crosslinking agent.14. The composition according to claim 10 , wherein the composition is used in film formation for lithography.15. The composition according to claim 10 , wherein the composition is used in optical component formation.16. A method for forming a resist pattern claim 14 , comprising the steps of: forming a photoresist layer on a substrate using the composition according to ; and then irradiating a predetermined region of the photoresist layer with radiation for development.17. A method for forming a resist pattern claim 14 , comprising the steps of: forming an underlayer film on a substrate using the composition according to ; forming at least one photoresist layer on the underlayer film; and then irradiating a predetermined region of the photoresist layer with radiation for development.18. A method for forming a circuit pattern claim 14 , comprising the steps of: forming an underlayer film on a substrate using the composition according to ; forming an intermediate layer film on the underlayer film using a resist intermediate layer film material; forming at least one photoresist layer on the intermediate layer film; then irradiating a predetermined region of the photoresist layer with radiation for development ...

COMPOSITIONS FOR THE TREATMENT OF FIBROSIS AND FIBROSIS-RELATED CONDITIONS

The present invention relates to novel compounds and their use in the prophylactic and/or therapeutic treatment of fibrosis and fibrosis-related conditions. 2. The compound according to claim 1 , wherein the saturated claim 1 , partly saturated or unsaturated 5- or 6-membered heterocyclyl contains one or more of N claim 1 , S or O claim 1 , optionally substituted with one or more oxo claim 1 , Calkyl claim 1 , amino claim 1 , hydroxyl or halo substituents.3. The compound according to claim 1 , wherein the saturated claim 1 , partly saturated or unsaturated 5- or 6-membered heterocyclyl is selected from pyrrolyl claim 1 , pyrazolyl claim 1 , imidazolyl claim 1 , triazolyl claim 1 , imidazolidinyl claim 1 , pyrrolidinyl claim 1 , pyrrolidinylidene claim 1 , dihydropyrrolyl claim 1 , isoxazolyl dihydrooxazolyl claim 1 , isoxazolidinyl claim 1 , oxazolidinyl and oxazolyl claim 1 , optionally substituted with one or more oxo claim 1 , Calkyl claim 1 , amino claim 1 , hydroxyl or halo substituents.4. The compound according to claim 1 , wherein the Calkoxyl amine is aminooxymethyl.5. The compound according to claim 1 , wherein the Calkyl amine is optionally substituted with one or more of Calkyl claim 1 , Chalo alkyl claim 1 , hydroxyl or halo claim 1 , preferably mono- claim 1 , di- or tri-substituted halo alkyl claim 1 , most preferably tri-fluoro methane.6. The compound according to claim 1 , wherein the Calkyl carboxylic acid is carboxylic acid.7. The compound according to claim 1 , wherein the Calkyl hydroxyl is methyl hydroxyl.8. The compound according to claim 1 , wherein the Calkyl bicyclic heterocyclyl is selected from indolyl claim 1 , isoindolyl claim 1 , insolinyl and isoindolinyl claim 1 , optionally substituted with one or more oxo claim 1 , preferably dioxo.9. The compound according to claim 1 , wherein the Calkoxyl bicyclic heterocyclyl is selected indolyl claim 1 , isoindolyl claim 1 , insolinyl and isoindolinyl claim 1 , optionally substituted with one or ...

METHOD FOR PRODUCING RECYCLED MATERIAL, AND TIRE AND METHOD FOR PRODUCING TIRE

There is provided a method for producing a recycled material, whereby a recycled material can be efficiently obtained from a tire. The method for producing a recycled material according to the present invention includes a step of subjecting a tire to a gasification treatment to generate a gas containing a C1 gas from the tire, and a step of obtaining a recycled material containing at least one species selected from the group consisting of isoprene, butadiene, a butanediol compound, a butanol compound, a butenal compound, succinic acid, and polymers of these compounds by using the gas containing the C1 gas. 111-. (canceled)12. A method for producing a tire , the method comprising: a step of subjecting a tire to a gasification treatment to generate a gas comprising a C1 gas from the tire , a step of obtaining a recycled tire material comprising at least one species selected from the group consisting of isoprene , butadiene , and polymers of these compounds by using the gas comprising the C1 gas , and a step of obtaining a tire by using the recycled tire material.13. The method for producing a tire according to claim 12 , wherein the tire to be used for the gasification treatment is a waste tire.14. The method for producing a tire according to claim 12 , wherein the gas comprising the C1 gas comprises COgas and hydrogen gas and x in the COgas is 1≤x≤2.151. The method for producing a tire according to claim 13 , wherein the gas comprising the C gas comprises COgas and hydrogen gas and x in the COgas is 1≤x≤2.16. The method for producing a tire according to claim 12 , wherein the step of obtaining a recycled tire material is a step of synthesizing isoprene by growing a microbial catalyst prepared by introducing a nucleic acid capable of coding isoprene synthase into a Clostridium microorganism in the presence of the resulting gas containing the C1 gas and hydrogen gas to obtain a recycled tire material comprising at least one species selected from the group consisting of ...

Process to prepare treprostinil, the active ingredient in remodulin®

This present invention relates to an improved process to prepare prostacyclin derivatives. One embodiment provides for an improved process to convert benzindene triol to treprostinil via salts of treprostinil and to purify treprostinil.

Phenolic epoxy compounds

Disclosed herein are compositions and methods of making phenolic compounds, and resins comprising these phenolic compounds. The compounds include multifunctional epoxies, amino glycidyl derivatives, and multi-functional amines prepared from hydroxymethyl derivatives of phenols and bisphenols.

MONOMER, HARDMASK COMPOSITION INCLUDING MONOMER, AND METHOD FOR FORMING PATTERN BY USING HARDMASK COMPOSITION

Disclosed are a monomer represented by the following Chemical Formula 1 for a hardmask composition, a hardmask composition including the monomer, and a method of forming patterns using the hardmask composition. 3. The monomer of claim 1 , wherein at least one of Ato Ais a polycyclic aromatic group.4. The monomer of claim 3 , wherein the Aand Aare each independently a benzene group claim 3 , a naphthalene group claim 3 , a biphenyl group claim 3 , or a pyrene group claim 3 , and{'sup': '2', 'the Ais a pyrene group, a perylene group, a benzoperylene group, or a coronene group.'}7. The monomer of claim 1 , wherein the monomer has a molecular weight of 500 to 5 claim 1 ,000.10. The hardmask composition of claim 8 , wherein at least one of the Ato Ais a polycyclic aromatic group.11. The hardmask composition of claim 10 , wherein the Aand Aare each independently benzene group claim 10 , naphthalene group claim 10 , biphenyl group or pyrene group claim 10 , and{'sup': '2', 'the Ais a pyrene group, a perylene group, a benzoperylene group, or a coronene group.'}14. The hardmask composition of claim 8 , wherein the monomer has a molecular weight of 500 to 5 claim 8 ,000.15. The hardmask composition of claim 8 , wherein the monomer is included in an amount of 0.1 to 50 wt % based on the total amount of the hardmask composition.16. A method of forming patterns claim 8 , comprisingproviding a material layer on a substrate,{'claim-ref': {'@idref': 'CLM-00008', 'claim 8'}, 'applying the hardmask composition of on the material layer,'}heat-treating the hardmask composition to form a hardmask layer,forming a silicon-containing thin layer on the hardmask layer,forming a photoresist layer on the silicon-containing thin layer,exposing and developing the photoresist layer to form a photoresist patternselectively removing the silicon-containing thin layer and the hardmask layer using the photoresist pattern to expose a part of the material layer, andetching an exposed part of the ...

NOVEL COMPOUNDS WHICH ACTIVATE ESTROGEN RECEPTORS AND COMPOSITIONS AND METHODS OF USING THE SAME

Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective activities. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of treating a disease or condition including administering the compounds. The disease or condition may include postmenopausal symptoms, cardiovascular disease, stroke, vascular disease, bone disease, metabolic disease, arthritis, osteoporosis, obesity, vasomotor/hot flush, cognitive decline, cancer including breast cancer. 2. A compound according claim 1 , wherein Calkyl or Calkoxy is substituted with one or more of halo claim 1 , cyano claim 1 , amino claim 1 , hydroxy claim 1 , and Calkoxy claim 1 ,3. A compound according to any one of or claim 1 , wherein Ris hydroxyl.4. A compound according to any one of - claim 1 , wherein at least one of Rand Ris Calkyl.5. A compound according to claim 4 , wherein both Rand Rare Calkyl.6. A compound according to claim 4 , wherein at least one of Rand Ris methyl.7. A compound according to claim 6 , wherein both Rand Rare methyl.8. A compound according to any one of - claim 6 , wherein Calkyl is substituted.9. A compound according to claim 8 , wherein the substituent is hydroxy.10. A compound according to any one of - claim 8 , wherein Rand Rare independently selected from H claim 8 , methyl claim 8 , ethyl claim 8 , chloro claim 8 , —CHOH claim 8 , and —CHOMe.11. A compound according to any one of - claim 8 , wherein Ris selected from H claim 8 , OH claim 8 , oxo claim 8 , chloro claim 8 , cyano claim 8 , or methoxy.12. A compound according to any one of - claim 8 , wherein Ris selected from fluoro claim 8 , chloro claim 8 , bromo claim 8 , methoxy claim 8 , hydroxy claim 8 , or oxo.13. A compound according to any one of - claim 8 , wherein Ris H.14. A compound according to any one of - claim 8 , wherein Ris —CCH.15. A compound according any one of - claim 8 , or claim 8 , ...

用于治疗纤维化和纤维化相关病症的组合物

本发明涉及新的化合物及其预防性治疗和/或治疗性治疗纤维化及纤维化相关病症的用途。

섬유증 및 섬유증 관련 질병 치료용 조성물

본 발명은 섬유증 및 섬유증 관련 질병의 예방 및/또는 치료에서의 신규 화합물 및 이의 용도에 관한 것이다.

Monomer, organic layer composition, organic layer, and method of forming patterns

화학식 1로 표현되는 모노머, 상기 모노머를 포함하는 유기막 조성물, 상기 유기막 조성물로부터 제조된 유기막, 및 상기 유기막 조성물을 사용하는 패턴형성방법에 관한 것이다. 상기 화학식 1의 정의는 명세서 내에 기재한 바와 같다. A monomer represented by the general formula (1), an organic film composition comprising the monomer, an organic film prepared from the organic film composition, and a pattern forming method using the organic film composition. The definition of the above formula (1) is as described in the specification.

9,9′-联蒽类蓝光多功能材料及其应用

本发明公开了一种9,9′‑联蒽类蓝光多功能材料及其应用。本发明通过不同的给电子基团和吸电子基团取代联蒽上的氢原子，通过改变取代基的性质、位置和数目，利用取代基的空间效应和电子效应不仅能够调节材料的最高占据轨道和最低空轨道能级，而且改善材料的发光性能、电荷传输性能以及稳定性。该类材料不仅可以作为深蓝光主体材料，还可以作为发光材料，均具有优异的器件性能。且材料易于合成、提纯方便，可广泛应用于有机场效应晶体管，有机电致发光器件和有机光伏太阳能电池领域。

174; an improved process to prepare treprostinil the active ingredient in remodulin174;

본 발명은 프로스타시클린 유도체의 개선된 제조 방법에 관한 것이다. 한 가지 구체예는 트레프로스티닐의 염에 의해 벤즈인덴 트리올을 트레프로스티닐로 전환시키고, 트레프로스티닐을 정제하는 개선된 방법을 제공한다. The present invention relates to an improved process for the preparation of prostacyclin derivatives. One embodiment provides an improved method of converting benzindentiol to treprostinil by the salt of treprostinil and purifying the treprostinil.

Monomer for hardmask composition and hardmask composition including the monomer and method of forming patterns using the hardmask composition

하기 화학식 1로 표현되는 하드마스크 조성물용 모노머, 상기 모노머를 포함하는 하드마스크 조성물 및 이를 사용한 패턴 형성 방법에 관한 것이다. [화학식 1] 상기 화학식 1에서, A, A′, A″, L, L′,X 1 내지 X 3 및 n은 명세서에서 정의한 바와 같다.

Method of purifying bisphenol-a

본 발명은 낙하 막 동적 결정화기 속에서 분별 용융 결정화시킴으로써 불순한 비스페놀-A를 정제하는 방법에 관한 것이다. 놀랍게도, 비스페놀-A는 이의 사방정계 결정 형태로 동결된다. 보통의 용융 결정에 있어서는 열분해 및 촉매 분해의 문제점이 발생하게 되지만, 낙하 막 동적 결정화기 속에서의 분별 용융 결정화는 비교적 짧은 시간이 필요하기 때문에 심각한 분해가 발생하지 않는다. The present invention relates to a process for purifying impure bisphenol-A by fractional melt crystallization in a falling film dynamic crystallizer. Surprisingly, bisphenol-A is frozen in its tetragonal crystal form. Problems of pyrolysis and catalytic cracking occur in ordinary melt crystals, but fractional melt crystallization in a falling film dynamic crystallizer requires a relatively short time so that no severe cracking occurs.

An improved process to prepare treprostinil, the active ingredient in remodulin®

본 발명은 프로스타시클린 유도체의 개선된 제조 방법에 관한 것이다. 한 가지 구체예는 트레프로스티닐의 염에 의해 벤즈인덴 트리올을 트레프로스티닐로 전환시키고, 트레프로스티닐을 정제하는 개선된 방법을 제공한다.

Monomer for hardmask composition and hardmask composition including the monomer and method of forming patterns using the hardmask composition

하기 화학식 1로 표현되는 하드마스크 조성물용 모노머, 상기 모노머를 포함하는 하드마스크 조성물 및 이를 사용한 패턴 형성 방법에 관한 것이다. [화학식 1] 상기 화학식 1에서, A, A′, A″, L, L′,X 1 내지 X 3 및 n은 명세서에서 정의한 바와 같다. A hard mask composition comprising the monomer, and a pattern forming method using the same. [Chemical Formula 1] Wherein A, A ', A ", L, L', X 1 to X 3 and n are as defined in the specification.

Method for preparing 2,3,6,7,10,11-hexahydroxytriphenylene

본 발명은 간편하고 효율적인 고순도 2,3,6,7,10,11-헥사히드록시트리페닐렌의 공업적 제조법을 제공한다. 본 발명은 카테콜과 과산화물을 반응시키는 것을 특징으로 하는 2,3,6,7,10,11-헥사히드록시트리페닐렌의 제조 방법에 관한 것이다. The present invention provides a simple and efficient industrial preparation of high purity 2,3,6,7,10,11-hexahydroxytriphenylene. The present invention relates to a method for producing 2,3,6,7,10,11-hexahydroxytriphenylene, characterized by reacting catechol and peroxide.

Organometallic complex

有機金属錯体、その製造方法、ならびにデバイスおよびサブアセンブリにおけるその使用を提供する。

Monomer for hardmask composition and hardmask composition including the monomer and method of forming patterns using the hardmask composition

하기 화학식 1로 표현되는 하드마스크 조성물용 모노머, 상기 모노머를 포함하는 하드마스크 조성물 및 이를 사용한 패턴 형성 방법에 관한 것이다. [화학식 1] 상기 화학식 1에서, A, A′, L, X, X′, X″ 및 k, m 및 n은 명세서에서 정의한 바와 같다. A hard mask composition comprising the monomer, and a pattern forming method using the same. [Chemical Formula 1] A, A ', L, X, X', X "and k, m and n are as defined in the specification.

Organometallic complexes

본 발명은, 유기금속 착체, 그의 제조 방법 및 그의 장치 및 서브-어셈블리에서의 용도를 제공한다. 유기금속 착체, 서브-어셈블리, 유기 전자 장치

Underlayer film forming material for lithography, composition for forming an underlayer film for lithography, underlayer film for lithography and its manufacturing method, pattern forming method, resin, and purification method.

Monomer For Hardmask Composition, Hardmask Composition Including Monomer, And Method Of Forming Patterns By Using Hardmask Composition

本发明公开了一种由以下化学式1表示的用于硬掩膜组合物的单体、包括该单体的硬掩膜组合物、以及使用该硬掩膜组合物形成图案的方法。在以下化学式1中，A、A'、A″、L、L'、X、X'、m、和n与在具体实施方式中的定义相同。[化学式1]

An improved process to prepare treprostinil, the active ingredient in Remodulin

本发明涉及制备前列环素衍生物的改良方法。一种实施方式提供通过曲前列素的盐将苯并茚三元醇转化为曲前列素的改良方法并且提供纯化曲前列素的改良方法。

New materials for organic electroluminescent devices

Die vorliegende Erfindung betrifft die Verbindungen der Formel (1) und organische Elektrolumineszenzvorrichtungen, insbesondere blau emittierende Vorrichtungen, in denen diese Verbindungen als Hostmaterial oder Dotand in der emittierenden Schicht und/oder als Lochtransportmaterial und/oder als Elektronentransportmaterial verwendet werden. The present invention relates to the compounds of the formula (1) and organic electroluminescent devices, in particular blue-emitting devices, in which these compounds are used as host material or dopant in the emitting layer and / or as hole transport material and / or as electron transport material.

Organometallic complexes

Organometallic complexes are provided, methods for making the same, and their use in devices and sub-assemblies.

Method for producing 2,3,6,7,10,11-hexahydroxytriphenylene

본 발명은 간편하고 효율적인 고순도 2,3,6,7,10,11-헥사히드록시트리페닐렌의 공업적 제조법을 제공한다. 본 발명은 카테콜과 과산화물을 반응시키는 것을 특징으로 하는 2,3,6,7,10,11-헥사히드록시트리페닐렌의 제조 방법에 관한 것이다.

Material for forming underlayer film for lithography, composition for forming underlayer film for lithography, and method for producing same

本实施方式提供一种光刻用下层膜形成材料，其含有下述式(1)所示的化合物或包含源自下述式(1)所示的化合物的结构单元的树脂中的至少任一种。式(1)中，R 1 为碳数1～60的2n价基团或单键，R 2 各自独立地为卤素原子、碳数1～10的直链状、支链状或者环状的烷基、碳数6～10的芳基、碳数2～10的烯基、碳数1～30的烷氧基、硫醇基、羟基或羟基的氢原子被酸解离性基团取代而成的基团，在同一萘环或苯环中可以相同也可以不同，此处，至少1个R 2 为羟基的氢原子被酸解离性基团取代而成的基团，n为1～4的整数，n为2以上的整数时，n个[]内的结构单元的结构式可以相同也可以不同，X表示氧原子、硫原子或未桥接，m 2 各自独立地为0～7的整数，其中，至少1个m 2 为1～7的整数，q各自独立地为0或1。

Monomer for hardmask composition and hardmask composition including the monomer and method of forming patterns using the hardmask composition

하기 화학식 1로 표현되는 하드마스크 조성물용 모노머, 상기 모노머를 포함하는 하드마스크 조성물 및 이를 사용한 패턴 형성 방법에 관한 것이다. [화학식 1] 상기 화학식 1에서, A, A′, A″, L, L′, X, X′, m 및 n은 명세서에서 정의한 바와 같다. A hard mask composition comprising the monomer, and a pattern forming method using the same. [Chemical Formula 1] In Formula 1, A, A ', A ", L, L', X, X ', m and n are as defined in the specification.

Liquid crystal composition and liquid crystal display element

The present invention addresses the problem of providing: a liquid crystal composition which contains a polymerizable compound for producing a PSA type or PSVA type liquid crystal display element that has a sufficient pretilt angle and excellent response performance, said polymerizable compound having a sufficiently high polymerization rate and enabling an element that uses said polymerizable compound to be free from or extremely suppressed in display defects due to change of the pretilt angle; and a liquid crystal display element which uses this liquid crystal composition. The present invention provides: a liquid crystal composition which contains one or more polymerizable compounds represented by general formula (I); and a liquid crystal display element which uses this liquid crystal composition.

Organic Dielectrics Composition and Organic Thin Film Transistor Comprising Organic Dielectric Film Using the Same

본 발명은 차세대 유연디스플레이(Flexible Display)의 소자로 이용이 가능한 유기박막트랜지스터(OTFT, organic thin film transistor)의 구성 성분 중 게이트절연막의 유기절연체로 이용할 수 있는 신규한 유기절연체 조성물 및 이를 이용한 유기절연막을 함유하는 유기박막트랜지스터에 관한 것으로서, 상기 유기절연체 조성물은 페놀노볼락수지 및 이미다졸 유도체를 포함하여 이루어지는 것을 특징으로 하는데, 상기 페놀노볼락수지 및 이미다졸 유도체는 상호 분자간 수소결합에 의한 복합체(Complex)를 형성하는 것을 특징으로 하며 이러한 복합체를 유기박막트랜지스터의 게이트절연막으로 형성할 경우 소자의 전기적 특성을 향상시키고 요구되는 박막특성을 충족시켜 우수한 소자를 제공할 수 있게 한다. The present invention provides a novel organic insulator composition which can be used as an organic insulator of a gate insulating film among the components of an organic thin film transistor (OTFT) that can be used as a device of a next-generation flexible display, and an organic insulating film using the same The organic insulator composition comprises a phenol novolak resin and an imidazole derivative, wherein the phenol novolak resin and the imidazole derivative are formed by a complex of hydrogen molecules. When the complex is formed as a gate insulating film of the organic thin film transistor, it is possible to provide an excellent device by improving the electrical properties of the device and satisfying the required thin film properties.

2-FLUORETHOXY-BENZENIC DERIVATIVES, THEIR PREPARATION AND INSECTICIDE AGENTS CONTAINING SAME

DERIVES DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE X REPRESENTE UN ATOME D'OXYGENE OU DE SOUFRE, R ET R SONT H OU UN GROUPE ALKYLE, N REPRESENTE 0 OU 1, ET A REPRESENTE UN GROUPE DE FORMULE GENERALE: (CF DESSIN DANS BOPI) DANS LAQUELLE R ET R REPRESENTENT H, UN HALOGENE, UN GROUPE ALKYLE, ALKOXY, ALKYLTHIO, HALOGENOALKYLE, HALOGENO-ALKYLTHIO, OU ENSEMBLE UN METHYLENEDIOXY, R ET R REPRESENTENT H OU UN ALKYLE, ET P ET M SONT 0 OU 1. AGENTS INSECTICIDES OU ACARICIDES. DERIVATIVES OF GENERAL FORMULA: (CF DRAWING IN BOPI) IN WHICH X REPRESENTS AN ATOM OF OXYGEN OR SULFUR, R AND R ARE H OR AN ALKYL GROUP, N REPRESENTS 0 OR 1, AND A REPRESENTS A GROUP OF GENERAL FORMULA: ( CF DRAWING IN BOPI) IN WHICH R AND R REPRESENT H, A HALOGEN, AN ALKYL GROUP, ALKOXY, ALKYLTHIO, HALOGENOALKYL, HALOGENO-ALKYLTHIO, OR TOGETHER A METHYLENEDIOXY, R AND R AND R OR UNMETHYLENEDIOXY, R AND R AND R OR UNPRESENT 0 AND M REPRESENT OR 1. INSECTICIDAL OR ACARICIDAL AGENTS.

Selected block phenolic oligomers and their use in phenolic resin compositions and in radiation-sensitive resist compositions

Block phenolic oligomers of the formula (I): ##STR1## These may be reacted alone or with selected phenolic monomers during or after the formation of a phenolic novolak resin thereby said resin having at least one unit of formula (II): ##STR2##

Radiation-sensitive composition

A radiation-sensitive composition containing a resist compound having a high sensitivity, a high resolution, a high etching resistance, and a low outgas which forms a resist pattern with a good shape is described. Further described is a method of forming a resist pattern using the radiation-sensitive composition. Still further described are a novel composition for forming a photoresist under coat film which is excellent in optical properties and etching resistance and contains substantially no sublimable substance and an under coat film formed by the composition. Still further described are a radiation-sensitive composition containing a solvent and a cyclic compound having a specific structure, for example, a cyclic compound (A) having a molecular weight of 700 to 5000 which is synthesized by the condensation reaction of a compound having 2 to 59 carbon atoms and 1 to 4 formyl groups (aldehyde compound (A1)) with a compound having 6 to 15 carbon atoms and 1 to 3 phenolic hydroxyl groups (phenol compound (A2)), and a cyclic compound for use in the radiation-sensitive composition.

Lithographic film formation material, composition for lithographic film formation, lithographic film, pattern formation method, and purification method

Process for Preparing Monodisperse Cation-Exchanger Gels

본 발명은 a) 90.5 내지 97.99 중량%의 스티렌, 2 내지 7 중량%의 디비닐벤젠 및 0.01 내지 2.5 중량%의 자유 라디칼 생성 물질을 포함하는 모노머 혼합물 1로부터 제조된 단순 분산의 마이크로캡슐화된 모노머 방울을 수성 현탁액 중에서 중합하여 76 내지 100 % 전환하고, b) 70.5 내지 95.99 중량%의 스티렌, 4 내지 15 중량%의 디비닐벤젠, 0 내지 12 중량%의 제3 코모노머 및 0.01 내지 2.5 중량%의 하나 이상의 자유 라디칼 생성 물질로부터 제조된 모노머 혼합물 2를 이 모노머 혼합물 2의 50 내지 100 중량% 부분은 모노머 혼합물 2로부터의 하나 이상의 자유 라디칼 생성 물질이 활성인 중합 조건 하에서 첨가하는 방식으로 첨가하여 코폴리머를 형성하고, 마지막으로 c) 공정 단계 b)로부터의 반응 생성물을 술폰화에 의해 관능기화하여 얻는 증가된 내산화성 및 높은 삼투 안정성 및 순도를 갖는 단순 분산 양이온 교환 겔의 제조 방법 및 양이온 교환제, 및 이의 용도에 관한 것이다.

Monomer for hardmask composition, hardmask composition including monomer, and pattern forming method using hardmask composition

本发明涉及一种由化学式1表示的用于硬掩模组合物的单体、包括该单体的硬掩模组合物、以及使用其的图案形成方法。

Resist underlayer film composition, patterning process, and compound

The present invention provides a resist underlayer film composition for lithography, containing a compound having an indenofluorene structure. This resist underlayer film composition is excellent in filling property, generates little outgas, and has high heat resistance.

Preparation process of 4,4'-biphenol, precursor of same and preparation process of precursor

Abstract A novel compound, 4-(4-hydroxyphenyl)-3-cyclohexene-1-ol, and a novel preparation process of 4,4'-biphenol by using the novel compound as the raw material. 4-(4-Hydroxyphenyl)-3-cyclohexene-1-ol can be obtained by conducting a thermal decomposition reaction of 4,4-bis(4-hydroxyphenyl)cyclohexanol. 4,4'-Biphenol can be industrially manufactured by conducting a dehydrogenation reaction of 4-(4-hydroxyphenyl)-3-cyclohexene-1-ol.

Tolterodine, compositions and uses thereof, and preparation of the same

Racemic tolterodine free base in crystalline form, tolterodine with improved purity, compositions and uses thereof, and processes of preparing the same.

A kind of preparation method and application of full-color organic long-afterglow material

本发明公开了一种全彩有机长余辉材料的制备方法和应用，该方法以聚乙烯醇和磷光体芘甲酸衍生物为原料，在超声条件下混合即可，成分简单，制备方法简单易控，具有生产成本低、原料来源广等优势，为简易、高效产业化生产全彩超长有机磷光材料提供新的理论指导及技术支持，也丰富了全彩超长有机磷光材料的制备方法。制备的全彩有机长余辉材料具有较强的磷光发射和延迟磷光发射，由于其具有激发光依赖的特点，使得这种材料能够实现从蓝光到红光的全色域发光。可规模化地在包装盒，票据以及商标上面打印，从而实现更高级别的防伪功能。

Novel compounds which activate estrogen receptors and compositions and methods of using the same

Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective activities. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of treating a disease or condition including administering the compounds. The disease or condition may include postmenopausal symptoms, cardiovascular disease, stroke, vascular disease, bone disease, metabolic disease, arthritis, osteoporosis, obesity, vasomotor/hot flush, cognitive decline, cancer including breast cancer.

Radiation-sensitive composition

Phosphonium compound, epoxy resin composition including the same and semiconductor device prepared from the same

A phosphonium compound, an epoxy resin composition, a method of preparing a phosphonium compound, and a semiconductor device encapsulated with the epoxy resin composition, the compound being represented by Formula 1:

Novel Terphenyl Compounds

본 발명은 화학식 1의 테르페닐 화합물에 관한 것이다. 이 화합물은 액정 조성물에 사용하기에 적합하다. 상기 식에서, 각 R 1 및 R 2 는 동일하거나 상이하고, 알킬, 알킬옥시, 알케닐, 알케닐옥시, 알키닐, 알키닐옥시, 로 구성된 군으로부터 선택되나, 단 R 1 과 R 2 중 적어도 하나는 이며, *는 비대칭 탄소원자를 나타내고, 각 R 3 및 R 4 는 동일하거나 상이하고, 알킬, 알케닐 또는 알키닐기이고, Z는 각 테르페닐 탄소에서 수소 및 불소로부터 독립적으로 선택된다.

Liquid crystal composition and liquid crystal display element

Novel 1,3-diphenylpropane derivative having inhibitive activity against tyrosinase and process for preparation thereof

PURPOSE: 1,3-diphenylpropane derivative is provided to ensure the inhibition ability against Tyrosinase activity by reduction process of specific compounds in the presence of the ethers solvent and the reduction agent of lithium aluminum hydride(LAH). CONSTITUTION: The 1,3-diphenylpropane derivative of formula I having inhibition ability against Tyrosinase activity (wherein R1 is hydrogen or C1-C10 alkyl groups; R2 is C1-C5 alkyl or C1-C5 alkoxyalkyl group; otherwise, R1 and R2 together includes hetero-atomic oxygen and forms 5- or 6-membered polycycle with or without substitution by C1-C5 alkyl groups; R3 is hydrogen or C1-C7 alkyl group; R4 is hydrogen or hydroxy group; R5 and R6 each represent hydrogen or C1-C5 alkyl group) is produced by reducing the compound of formula IV to form the compound of formula V; then removing its protecting groups from the resulting compound to obtain the compound of formula Ia. (wherein P1, P2 and P3 represent protecting groups) in the solvent of diethylether or tetrahydrofuran(THF) and under LAH at 80-100 deg.C.

compounds; pharmaceutical composition; method for prophylactic or therapeutic treatment of fibrosis in a subject; uses of a compound; method for preventing, reducing or delaying fat accumulation in a subject's liver; method for preventing, reducing or delaying renal tubular cell death in a subject; and method for restoring normal tissue architecture in a subject

a presente invenção refere-se a novos compostos e ao seu uso no tratamento profilático e/ou terapêutico da fibrose e de patologias relacionadas com a fibrose. The present invention relates to novel compounds and their use in the prophylactic and / or therapeutic treatment of fibrosis and fibrosis-related disorders.

1-phenyl-2-phenylethane derivative

The present invention provides a novel compound which has activating activity selective for ERβ. A compound represented by formula (1) or a salt thereof. (In the formula, R 1 represents a cycloalkyl group having 3-8 carbon atoms, an alkenyl group which may be substituted by a halogen atom and has 2-6 carbon atoms, a five-membered nitrogen-containing heteroaryl group, a four- to six-membered cyclic amino group, an alkanoylamino group which may be substituted by a halogen atom and has 2-6 carbon atoms, a 1-trifluoromethyl-1-hydroxymethyl group or a 1-methylpropyl group; R 2 -R 5 may be the same or different and each represents a hydrogen atom or a fluorine atom; and R 6 represents a hydrogen atom or an alkanoyl group having 2-5 carbon atoms.)

Compounds which activate estrogen receptors and compositions and methods of using the same

Provided are compounds of formulae provided herein. The compounds may include pathway-preferential estrogens (PaPEs) derivatives with tissue-selective activities. Also provided are pharmaceutical compositions comprising the compounds, as well as methods of treating a disease or condition including administering the compounds. The disease or condition may include postmenopausal symptoms, cardiovascular disease, stroke, vascular disease, bone disease, metabolic disease, arthritis, osteoporosis, obesity, vasomotor/hot flush, cognitive decline, cancer including breast cancer.

Method for producing 2,3,6,7,10,11-hexahydroxytriphenylene

The present invention provides a simple and efficient method for producing high-purity 2,3,6,7,10,11-hexahydroxytriphenylene on an industrial scale. The method for producing 2,3,6,7,10,11-hexahydroxytriphenylene comprises reacting catechol with peroxide.

Dipyrenol, preparation method and application thereof

本发明涉及一种联芘酚及其制备方法和用途，本发明制备方法以1-溴芘和1-羟基芘为原料，钯催化下进行偶联反应，反应结束后处理得到联芘酚。本发明制备的联芘酚化合物是一类新化合物，以前未曾报道过，在光刻胶领域具有很好的应用。本发明与常规制备此类化合物的方法不同，涉及芳香类化合物的碳-氢键活化、偶联，而且钯催化剂易得，反应方法简单易行，反应条件易获得，具有非常高的应用价值和市场价值。

Monomer for hardmask composition and hardmask composition including the monomer and method of forming patterns using the hardmask composition

Tolterodine, compositions and uses thereof, and preparation of the same

Racemic tolterodine free base in crystalline form, tolterodine with improved purity, compositions and uses thereof, and processes of preparing the same.

Method for producing dis(4-hydroxyaryl) alkanes

The present invention relates to a process for producing bis(4-hydroxy-aryl)alkanes of high purity from addition products of bis(4-hydroxy-aryl)alkanes and aromatic hydroxy compounds which are obtained by the acid-catalysed reaction of the aromatic hydroxy compounds with ketones.

Urolithin a and derivatives thereof for use in therapy

In some embodiments of the invention, inventive compounds (e.g., Formula (I), (IA), (II), and (III), and urolithin derivatives) are disclosed. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein.

COMPOSITIONS FOR TREATMENT OF FIBROSE AND FIBROS-RELATED CONDITIONS

Biphenyl derivatives.

Compounds with activity at estrogen receptor

Disclosed herein are novel di-phenyl compounds and methods for using various di-phenyl compounds for treatment and prevention of diseases and disorders related to estrogen receptors.

Derivatives of 4-(1-(phenyl)-1-(hydroxy)-prop-1-yl)-resorcine, process for their preparation and medicines containing these compounds.

Cpds. of formula (I) are new: R1 and R2= H, halogen (pref. Cl, F or Br), trihalomethyl (pref. CF3 or CCl3), 1-3C alkyl (pref. Et or esp. Me) or 1-3C alkoxy (pref. OEt or esp. OMe). - (I) are useful for treating acute ethanol intoxication. E.g. they reduce the ethanol induced narcosis time to 30-70% at 0.3-20 mg/kg in tests in rats. Typical LD50 is 1250 mg/kg p.o. in rats. Daily dose is 0.1-300 (pref. 2-160) mg/kg, orally, rectally or parenterally. - 8 Cpds. (I) are specifically claimed, i.e. 4-(1-(X-substd. phenyl) -1-hydroxy-propyl)-resorcinols, where X is 3-trifluoromethyl, 2-trifluoromethyl, 4-fluoro, 2-methoxy, 4-chloro, 4-trifluoromethyl, 3-chloro or 2,5-dimethyl. (0/0) EPAB- EP-112587 B 4-(1-(phenyl)-1(hydroxy) -prop-1-yl)-resorcin derivs of the general formula (I) wherein R1 and R2 may be equal or different and stand for hydrogen atoms, - halogen atoms, trihalomethyl reisdues and/or alkyl residues or alkoxy residues having 1 to 3 carbon atom(s). - (17pp) USAB- US4510338 A New resorcinol derivs. have formula (I) where R1 and R2 are each H, halogen, trihalomethyl, 1-3C alkyl or alkoxy. Specific cpds. include 4-(1-(3-trifluoromethyl-phenyl) 1-hydroxypropyl)-resorcinol, 4-(1-(4-fluorophenyl) -1-hydroxypropyl)-resorcinol, and 4-(1-(2,5-dimethylphenyl) -1-hydroxypropyl)-resorcinol. Cpds. (I) are prepd. by (A) reacting 2', 4'-dihydroxy-propiophenone with a Grignard cpd. of formula (II). (B) reacting 2', 4'-dihydroxy-propiophenone with an organometallic cpd. of formula (III) (where M is an alkali metal). (C) reacting a benzophenone of formula (IV) with an organometallic cpd. contg. an ethyl gp., pref. an ethyl magnesium halide or ethyl lithium.

Microbial preparation of catechols

A process for preparing catechol derivatives comprising the steps of: i) admixing an aromatic compound with a dioxygenase enzyme to provide an intermediate cis-dihydrodiol aromatic compound; ii) separating the cis-dihydrodiol aromatic compound from the dioxygenase enzyme; and iii) directly admixing the cis-dihydrodiol aromatic compound with a dehydrogenase enzyme to provide a catechol.

Process for preparing monodisperse cation-exchanger gels

The invention relates to a process for preparing monodisperse cation-exchanger gels with increased oxidation resistance and with high osmotic stability and purity by (a) polymerizing monodisperse microencapsulated monomer droplets made from a monomer mixture (1) comprising from 90.5 to 97.99% by weight of styrene, from 2 to 7% by weight of divinylbenzene, and from 0.01 to 2.5% by weight of free-radical generator in aqueous suspension to conversions of from 76 to 100%, (b) adding a monomer mixture (2) made from 70.5 to 95.99% by weight of styrene, from 4 to 15% by weight of divinylbenzene, from 0 to 12% by weight of a third comonomer, and from 0.01 to 2.5% by weight of one or more free-radical generators to form a copolymer, wherein a portion of from 50 to 100% by weight of the monomer mixture (2) is added under polymerization conditions in which at least one free-radical generator from monomer mixture (2) is active, and (c) functionalizing the reaction product from process step (b) by sulfonation.

Urolithin A and derivatives thereof for use in therapy

In some embodiments of the invention, inventive compounds (e.g., Formula (I), (IA), (II), and (III), and urolithin derivatives) are disclosed. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein.

Method for producing 2,3,6,7,10,11-hexahydroxytriphenylene

The present invention provides a simple and efficient method for producing high-purity 2,3,6,7,10,11-hexahydroxytriphenylene on an industrial scale. The method for producing 2,3,6,7,10,11-hexahydroxytriphenylene comprises reacting catechol with peroxide.

Novel 1,3-diphenylpropane derivative having inhibitory activity on tyrosinase and method for producing the same

(57)【要約】 本発明は下式（Ｉ） 式中、 --- は、二重結合または単一結合を表し、Ｒ 1 は、水素またはＣ 1 −Ｃ 10 のアルキル、Ｒ 2 は、Ｃ 1 −Ｃ 5 のアルキル若しくはＣ 1 −Ｃ 5 のアルコキシアルキルか、またはＲ 1 及びＲ 2 は結合して、Ｃ 1 −Ｃ 5 のアルキルで置換されていても良い５〜６員の複素環か、またはヘテロ原子として酸素を含有する５〜６員の複素環を表し、Ｒ 3 は、水素またはＣ 1 −Ｃ 7 のアルキルを表し、Ｒ 4 は、水素、ヒドロキシまたはオキソを表し、Ｒ 5 及びＲ 6 は同一または異なって、水素またはＣ 1 −Ｃ 5 のアルキルを表す。で表される、チロシナーゼに対する阻害活性を有する新規な１，３−ジフェニルプロパン誘導体及びその製造方法に関する。

1-phenyl-2-phenylethane derivative

Rezorcine derivatives, process for their preparation and pharmaceutical compositions containing them

Abstract The invention relates to new resorcin derivatives of the formula (I) (I) wherein R1 and R2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 3 carbon atoms or alkoxy having from one to 3 carbon atoms. According to another aspect of the invention there are provided processes for the preparation of these compounds. The compounds of the formula (I) are pharma-cologically active. In particular, they are suitable for the treatment of acute ethanolic intoxication. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.

Patent EP0550754A4

A polymerization inhibitor of vinyl-containing compounds consists of the product of interaction between 4-(dimethylamino)methyl-2,6-bis-(trebutyl)phenol and a non-organic acid or carbonic acid or an anhydride of an organic acid. The weight ratio between said components is 1-15:0, respectively. The process is carried out in the presence of a solvent at a temperature of up 120 °C.

Method for producing recycled material, and tire and method for producing tire

There is provided a method for producing a recycled material, whereby a recycled material can be efficiently obtained from a tire. The method for producing a recycled material according to the present invention includes a step of subjecting a tire to a gasification treatment to generate a gas containing a C1 gas from the tire, and a step of obtaining a recycled material containing at least one species selected from the group consisting of isoprene, butadiene, a butanediol compound, a butanol compound, a butenal compound, succinic acid, and polymers of these compounds by using the gas containing the C1 gas.

Substituted 4'-hydroxy-alpha-ethyl benzhydroles for use as medicaments.

Cpds. of formula (I) are claimed for use as medicaments, esp. for treating acute alcohol intoxication where R1 and R3= Me and R2= H, or R1 and R3= H and R2= CF3. - Prepn. of cpds. (I) comprises e.g. reacting 4-hydroxypropiophenone with a phenyl cpd. (II) (where M is alkali metal or MgX X is halogen). (I) are ca. 10 times more effective in reducing the duration of alcohol-induced sleep in rats. (I) may be administered orally, rectally or parenterally at daily doses of 0.1-300 (pref. 2-160) mg/kg. (0/0) EPAB- EP-112586 B Substituted 4'-hydroxy-alpha-ethyl-benzhydrols of the general formula (I) wherein R1 and R3 are standing for methyl radicals, and R2 represents hydrogen, or R1 and R3 are standing for hydrogen, and R2 represents a trifluoromethyl radical, for use as a medicament for the treatment of acute alcohol poisoning. - (9pp) USAB- US4593047 A Treatment of acute ethanolic intoxication comprises admin. of 0.1-300 mg/kg/day of 3-trifluoromethyl- 4'-hydroxy-alpha ethylbenzhydrol. - Prepn. may be e.g. by a reacting 4'-hydroxypropiophenone with organo-metallic cpd. - (I) in which 1 is H R2 is 3-CF3 M is Li, Na, K or Mg Hal or b redn. of (II) with EtMgHal or EtLi or c redn. of (III).

Optically active benzene derivatives, process for their preparation and liquid-crystalline composition which contains such derivatives as a liquid-crystalline compound and light-off elements

Hydroxyalkyl and oxoalkyl substituted phenols as analgesics and sedatives

Compounds useful for pharmacological and medicinal purposes having the formulae ##STR1## wherein R is H, C 1 -C 5 alkanoyl; R 1 is H, benzyl, C 1 -C 5 alkanoyl, P(O)(OH) 2 , --CO(CH 2 ) 2 COOH or a basic acyl group; each of R 2 and R 4 is H, C 1 -C 6 alkyl, phenyl, pyridyl or (CH 2 ) y C 6 H 5 ; y is 1-4; R 3 is H or CH 3 ; Z is C 1 -C 13 alkylene or --(alk 1 ) m --O--(alk 2 ) n --; each of (alk 1 ) and (alk 2 ) is C 1 -C 13 alkylene with the proviso that the summation of carbon atoms in (alk 1 ) plus (alk 2 ) is not greater than 13; each of m and n is 0 or 1; and W is H, pyridyl, phenyl, fluorophenyl or chlorophenyl; intermediates therefor and methods for their preparation and use.

RESORCIN DERIVATIVES AND ANALOGUE PROCEDURES FOR PREPARING THEM, PHARMACEUTICAL PREPARATIONS CONTAINING THESE, AND PROCEDURES FOR PREPARING THESE PHARMACEUTICAL PREPARATIONS

Lithographic film formation material, composition for lithographic film formation, lithographic film, pattern formation method, and purification method

The material for forming a film for lithography according to the present invention contains a compound represented by the following formula (1): wherein, each R° independently represents a monovalent group having an oxygen atom, a monovalent group having a sulfur atom, a monovalent group having a nitrogen atom, a hydrocarbon group or a halogen atom, and each p is independently an integer of 0 to 4.

FOERFARANDE FOER FRAMSTAELLNING AV 3- TRIFLUOROMETHYL- OCH 2,5-DIMETYL-4'-HYDROXI--ETHYL-BENZHYDROL.

PREPARATION PROCEDURE OF 3-TRIFLUOROMETIL-4'-HIDROXI - A-ETIL-BENZOL

The invention relates to the preparation of 3-trifluoromethyl- and 2,5-dimethyl-4'-hydroxy- alpha -ethyl-benzhydrol. Both compounds have so far been described only as metabolites of corresponding benzhydrol derivatives containing no hydroxyl group. Neither their physico-chemical characteristics nor their manufacturing processes have been disclosed in the known publications. 3-Trifluoromethyl- and 2,5-dimethyl-4'-hydroxy- alpha -ethyl-benzhydrol are suitable for the treatment of acute ethanolic intoxication. Accordingly, another aspect of the invention is a pharmaceutical composition containing one of these compounds as active ingredient.

Urolithin a and derivatives thereof for use in therapy

In some embodiments of the invention, inventive compounds (e.g., Formula (I), (IA), (II), and (III), and urolithin derivatives) are disclosed. Other embodiments include compositions (e.g., pharmaceutical compositions) comprising the inventive compound. Still other embodiments of the invention include compositions (e.g., pharmaceutical compositions) for treating, for example, certain diseases using the inventive compounds. Some embodiments include methods of using the inventive compound (e.g., in compositions or in pharmaceutical compositions) for administering and treating (e.g., diseases). Further embodiments include methods for making the inventive compounds. Additional embodiments of the invention are also discussed herein.

Bis(2-hydroxy-meta-alkyl-phenol) alkanes

1-phenyl-2-phenylethane derivative

Process for producing new alkane and alkene halides and pharmaceutical compositions comprising same

Film-forming material for lithography, film-forming composition for lithography, method for forming film or pattern for lithography, and purification method

本發明之微影用膜形成材料，其含有下述式(1)所示之化合物。 (式(1)中，R 0 各自獨立，為含氧原子之1價的基、含硫原子之1價的基、含氮原子之1價的基、烴基或鹵素原子，p各自獨立，為0~4之整數)。

PROCESS FOR THE PREPARATION OF NOVEL ALKANE AND ALKEN ABKOEMMLINGE

The invention provides novel compounds of the formula: <CHEM> in wherein m is 1 or 2, R6 and R7, which can be the same or different are H or an alkyl group of 1 to 4 carbon atoms, or <CHEM> wherein n is 0 to 4, R1 and R2 which can be the same or different are H, OH, alkoxy of 1 to 4 carbon atoms, benzyloxy or methoxymethoxy; R3 is H, OH, halogen, alkoxy of 1 to 4 carbon atoms, benzyloxy, methoxymethoxy, 2,3-dihydroxypropoxy or <CHEM> can form an N-containing three-, four-, five- or six-membered heterocyclic ring; R4 is OH, F, Cl, Br, I, mesyloxy, tosyloxy, formyloxy, alkylcarbonyloxy of 1 to 4 carbon atoms or CH2R4 is replaced by CHO; R5 is H or OH; or R4 and R5 together form an -O- bridge between the carbon atoms to which they are attached, and their non-toxic pharmaceutically acceptable salts and esters and mixtures thereof. Processes for the preparation of these compounds are described, and also novel pharmaceutical compositions containing them. These compounds exhibit valuable pharmacological properties as estrogenic, anti-estrogenic, and progestanic agents. They are also effective against oestrogen-dependent tumours. Certain compounds are useful as chemical intermediates for the preparation of pharmacologically active compounds of the invention.