Novel phytochemicals from extracts of maple syrups and maple trees and uses thereof

The present invention describes phytochemicals present in maple syrup and maple tree extracts by butanol, ethyl acetate and methanol. Novel compounds are isolated from maple syrups, including one compound Quebecol generated in the maple syrup manufacturing process. Also described are digesting extract of maple syrup. The phytochemicals may be used for the treatment or prevention of cancers, metabolic syndromes, diabetes, microorganism infections and/or antioxidants.

Cyclohexylbenzene Compositions

In a process for producing phenol and cyclohexanone, a feed comprising cyclohexylbenzene is oxidized to produce an oxidation reaction product comprising cyclohexyl-1-phenyl-1-hydroperoxide. At least a portion of the oxidation reaction product is then cleaved to produce a cleavage reaction product comprising phenol, cyclohexanone, and at least one contaminant. At least a portion of the cleavage reaction product is contacted with an acidic material to convert at least a portion of the at least one contaminant to a converted contaminant and thereby produce a modified reaction product. The oxidation reaction product may have at least 50 wt % of cyclohexylbenzene, no greater than 80 wt % of cyclo-hexyl-1-phenyl-1-hydroperoxide, and 0.1 wt % to 10 wt % of another hydroperoxide. 1. A composition comprising:a. at least 50 wt % of cyclohexylbenzene;b. no greater than 80 wt % of cyclo-hexyl-1-phenyl-1-hydroperoxide; andc. 0.1 wt % to 10 wt % of at least one of: cyclohexyl-1-phenyl-2-hydroperoxide, cyclohexyl-1-phenyl-3-hydroperoxide, cyclohexyl-1-phenyl-4-hydroperoxide, cyclopentyl-1-methyl-2-phenyl-2-hydroperoxide, cyclopentyl-1-methyl-3-phenyl-3-hydroperoxide, cyclopentyl-1-methyl-1-phenyl-2-hydroperoxide, cyclopentyl-1-methyl-1-phenyl-3-hydroperoxide; and cyclohexyl-1-phenyl-1,2-dihydroperoxide, cyclohexyl-1-phenyl-1,3-dihydroperoxide, cyclohexyl-1-phenyl-1,4-dihydroperoxide, cyclopentyl-1-methyl-2-phenyl-1,2-dihydroperoxide, cyclopentyl-1-methyl-2-phenyl-2,3-dihydroperoxide, cyclopentyl-1-methyl-2-phenyl-2,4-dihydroperoxide and cyclopentyl-1-methyl-2-phenyl-2,5-dihydroperoxide,wherein the wt % s are based upon the total weight of the composition.2. The composition of claim 1 , wherein the composition comprises 0.5 wt % to 5 wt % of at least one of: cyclohexyl-1-phenyl-2-hydroperoxide claim 1 , cyclohexyl-1-phenyl-3-hydroperoxide claim 1 , cyclohexyl-1-phenyl-4-hydroperoxide claim 1 , cyclopentyl-1-methyl-2-phenyl-2-hydroperoxide claim 1 , cyclopentyl-1-methyl-3-phenyl-3- ...

1-(7,10,10-trimethyl-4-bicyclo(6.2.0)decanyl)ethanone as novel aroma chemical

The present invention relates to 1-(7,10,10-trimethyl-4-bicyclo[6.2.0]decanyl)ethanone, the use of 1-(7,10,10-trimethyl-4-bicyclo[6.2.0]decanyl)ethanone as a fragrance or as flavor, to a method for imparting or modifying a scent or a flavor to a composition by including said compound into such composition, to a fragrance containing composition and/or a fragrance material containing said compound and to a process for preparing 1-(7,10,10-trimethyl-4-bicyclo[6.2.0]decanyl)ethanone.

DIMETHYLCYCLOBUTANONE COMPOUNDS, DIMETHYLCYCLOBUTANE COMPOUNDS, AND PROCESSES FOR PREPARING THE SAME

The present invention provides a process for preparing a dimethylcyclobutane compound of the following general formula (1A), the process comprising reacting a dimethylcyclobutanone compound of the following general formula (2) with a phosphonic ester compound of the following general formula (3) to produce an unsaturated ester compound of the following general formula (4), having a dimethylcyclobutane ring, and subjecting the unsaturated ester compound (4), having a dimethylcyclobutane ring, to a reduction reaction to produce the dimethylcyclobutane compound (1A). 4. A process for preparing an isopropenyl dimethylcyclobutane compound (5′) and/or an isopropylidene dimethylcyclobutane compound (6′) , the process comprising{'claim-ref': {'@idref': 'CLM-00003', 'claim 3'}, 'the process according to for preparing the isopropenyl dimethylcyclobutane compound (5) and/or the isopropylidene dimethylcyclobutane compound (6); and'}{'sup': 6', '6', '6, 'changing a specific group, X, in the isopropenyl dimethylcyclobutane compound (5) and/or the isopropylidene dimethylcyclobutane compound (6) to another group, X, among the options for Xdefined above, to produce the isopropenyl dimethylcyclobutane compound (5′) and/or the isopropylidene dimethylcyclobutane compound (6′).'}67.-. (canceled) The present invention relates to dimethylcyclobutanone compounds and dimethylcyclobutane compounds, both of which are useful intermediates for synthesis of insect sex pheromones, and processes for preparing the dimethylcyclobutnone compounds and the dimethylcyclobutane compounds.Insect sex pheromones are biologically active substances which usually have a function of attracting male individuals to female individuals, and exhibit high attracting activities in small amounts. Sex pheromones are widely used as a means of forecasting outbreaks of pests and confirming geographic spread (invasion into a specific area), and as a means of controlling pests. Widely used methods are a mass trapping method, ...

A thermo-responsive solution, and method of use therefor

The present invention relates to a thermo-responsive solution and in particular, a solution for use in an osmosis process that is suitable for separating or purifying solutes and or water from an aqueous solution on a large scale and under energy efficient conditions.

BI- AND TRICYCLIC COMPOUNDS FOR USE AS AROMA CHEMICALS

The present invention relates to bi- and tricyclic compounds of the general formula (I) (I) wherein the dashed lines independently of each other represent a single or a double bond, X represents a group of the formulae Xto Xwherein the asterisk denotes the point of attachment to the rest of the molecule, Rand R, independently of each other, are selected from hydrogen or methyl, or Rtogether with Rwith R form a methylene or ethylene group, R, R, R, R, Rand R, independently of each other, are selected from hydrogen or methyl, Ris selected from hydrogen, methyl or ethyl, and Ris methyl or ethyl, to a method of preparing said compounds, to the use of a bi- or tricyclic compounds or of mixtures of two or more bi- and tricyclic compounds or of a stereoisomer thereof or of a mixture of two or more stereoisomers thereof as aroma chemicals; to the use of a bi- or tricyclic compound for modifying the scent character of a fragranced composition; to an aroma chemical composition containing a bi- or tricyclic compound or a mixture of two or more bi- and tricyclic compounds or of a stereoisomer thereof or of a mixture of two or more stereoisomers thereof; and to a method of preparing a fragranced composition or for modifying the scent character of a fragranced composition, comprising incorporating a bi- or tricyclic compound or a mixture of two or more bi- and tricyclic compounds or of a stereoisomer thereof or of a mixture of two or more stereoisomers thereof into said composition.

Opsin-Binding Ligands, Compositions and Methods of Use

Compounds are disclosed that are useful for treating ophthalmic conditions caused by or related to production of toxic visual cycle products that accumulate in the eye, such as dry adult macular degeneration, as well as conditions caused by or related to the misfolding of mutant opsin proteins and/or the mis-localization of opsin proteins. Compositions of these compounds alone or in combination with other therapeutic agents are also described, along with therapeutic methods of using such compounds and/or compositions. Methods of synthesizing such agents are also disclosed.

Rare earth complex and light emitting element

A rare earth complex including a rare earth ion and a ligand coordinated with the rare earth ion and having a condensed polycyclic aromatic group. The condensed polycyclic aromatic group is a residue formed by removing a hydrogen atom from a condensed polycyclic aromatic compound represented by the following formula (I) or (II):

Oxocarbon-, Pseudooxocarbon- and Radialene Compounds and Their Use

The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them. 2. Use according to claim 1 , characterized in that Y is perfluoroalkyl.3. Use according to claim 1 , characterized in that aryl is partially or completely fluorinated.4. Use according to claim 1 , characterized in that hetaryl is selected from pyridyl claim 1 , pyrimidyl claim 1 , triazine claim 1 , or oxadiazole.5. Use according to claim 1 , characterized in that R1-R8 are independently selected from perhalogenated and/or partially halogenated alkyl groups.7. Oxocarbon- claim 6 , pseudooxocarbon- and radialene compounds according to claim 6 , characterized in that hetaryl is selected from pyridyl claim 6 , pyrimidyl claim 6 , triazine claim 6 , or oxadiazole.8. Use of oxocarbon- claim 6 , pseudooxocarbon- and radialene compounds according to or their radical anionic salts claim 6 , dianionic salts or charge transfer complexes with donors as organic ferromagnets.9. Use of oxocarbon- claim 6 , pseudooxocarbon- and radialene compounds according to or their radical anionic salts claim 6 , dianionic salts or their charge transfer complexes with donors as organic conductors.10. Organic semiconductive material containing at least one organic matrix compound and one doping agent claim 1 , characterized in that the doping agent is one or more oxocarbon- claim 1 , pseudooxocarbon- or radialene compounds according to .11. Organic semiconductive material according to claim 10 , characterized in that the molar doping ratio of doping agent to matrix molecule and/or the doping ratio of doping agent to monomeric units of a polymeric matrix molecule is between 1:1 and 1:100 claim 10 ,000.12. Electronic component with an ...

Sacubitril intermediate and preparation method thereof

The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril.

Molecular Catalysts Capable of Catalyzing Oxidation of Hydrocarbons and Method for Oxidizing Hydrocarbons

This invention relates to molecular catalysts and chemical reactions utilizing the same, and particularly to molecular catalysts for efficient catalytic oxidation of hydrocarbons, such as hydrocarbons from natural gas. The molecular catalytic platform provided herein is capable of the facile oxidation of hydrocarbons, for example, under ambient conditions such as near room temperature and atmospheric pressure.

C-glycoside derivative

The present invention involves a compound represented by general formula (I), a derivative thereof and a use thereof: wherein R 1 , R 2 , R 3 , R 4 , R 5a , R 5b , R 5c and X are defined as in the description.

METHOD FOR LINKAGE RECOVERY OF ORGANIC ACID IN AQUEOUS ORGANIC ACID SOLUTION

Disclosed is a method for linkage recovery of an organic acid in an aqueous organic acid solution. The method comprises: mixing a solution with an organic acid concentration lower than 20 wt % with a specific extractant and then subjecting same to counter-current extraction so as to obtain an extract phase and a raffinate phase; and subjecting the extract phase together with a solution with an acid concentration higher than 70 wt % to an azeotropic rectification so as to recover an organic acid. When the concentration of the aqueous organic acid solution is 20 wt %-70 wt %, the aqueous organic acid solution is extracted and concentrated to make the concentration of the aqueous organic acid solution higher than 70 wt %. The method is simple, and has a low energy consumption and a good recovery effect with respect to the single recovery of a low concentration aqueous organic acid solution; and the method does not need to newly add an azeotrope agent and saves on costs with respect to the single recovery of a high concentration aqueous organic acid solution. In such a cooperating manner, a reagent during recovery can be fully utilized, energy consumption is reduced, and a process is simplified. 1. A method for linkage recovery of an organic acid in an aqueous organic acid solution , comprising:mixing an organic acid solution with a concentration lower than 20 wt % and an extractant and then subjecting the mixture to countercurrent extraction to obtain an extract phase and a raffinate phase; andsubjecting the extract phase and an organic acid solution with a concentration higher than 70 wt % to azeotropic rectification together to recover the organic acid.2. The method according to claim 1 , wherein a volume ratio of the organic acid solution with a concentration lower than 20 wt % to the extractant is 1:(0.5-5).3. The method according to claim 1 , wherein a volume ratio of the organic acid solution with a concentration higher than 70 wt % to the extract phase is 1:(1-5 ...

VETIVER ODORANT

Trans isomers of formula (I) in the form of any of its stereoisomers or a mixture thereof are provided, wherein the bold and hatched lines indicate a relative or absolute configuration. Also provided are their uses as perfuming ingredients to impart vetiver/rooty notes e.g. in perfuming compositions or in consumer products. 4. The method according to claim 1 , characterized in that the compound of formula (I) is 1-((2SR claim 1 ,4aRS claim 1 ,8RS claim 1 ,8aSR)-4a claim 1 ,8-dimethyldecahydronaphthalen-2-yl)ethan-1-one claim 1 , 1-((2RS claim 1 ,4aRS claim 1 ,8RS claim 1 ,8aRS)-4a claim 1 ,8-dimethyldecahydronaphthalen-2-yl)ethan-1-one claim 1 , 1-((2RS claim 1 ,4aRS claim 1 ,8RS claim 1 ,8aSR)-4a claim 1 ,8-dimethyldecahydronaphthalen-2-yl)ethan-1-one and 1-((2SR claim 1 ,4aRS claim 1 ,8RS claim 1 ,8aRS)-4a claim 1 ,8-dimethyldecahydronaphthalen-2-yl)ethan-1-one and/or mixtures thereof.6. The compound according to claim 5 , characterized in that the compound of formula (III) is in a form of a composition of matter comprising claim 5 , or consisting of 1-((2RS claim 5 ,4aRS claim 5 ,8RS claim 5 , 8aRS)-4a claim 5 ,8-dimethyldecahydronaphthalen-2-yl)ethan-1-one and 1-((2 SR claim 5 ,4aRS claim 5 , 8RS claim 5 ,8 aRS)-4a claim 5 , 8-dimethyl decahydronaphthalen-2-yl)ethan-1-one.7. The compound according to claim 5 , characterized in that the compound of formula (III) is in a form of a composition of matter comprising claim 5 , or consisting of 1-((2SR claim 5 ,4aRS claim 5 ,8RS claim 5 ,8aSR)-4a claim 5 ,8-dimethyldecahydronaphthalen-2-yl)ethan-1-one claim 5 , 1-((2RS claim 5 ,4aRS claim 5 , 8RS claim 5 , 8aRS)-4a claim 5 , 8-dimethyldecahydronaphthalen-2-yl)ethan-1-one claim 5 , 1-((2RS claim 5 ,4aRS claim 5 ,8RS claim 5 ,8aS)-4a claim 5 ,8-dimethyldecahydronaphthalen-2-yl)ethan-1-one and 1-((2 SR claim 5 ,4aRS claim 5 , 8RS claim 5 , 8aRS)-4a claim 5 , 8-dimethyldecahydronaphthalen-2-yl)ethan-1-one.8. A perfuming composition comprising{'claim-ref': {'@idref': 'CLM- ...

USE OF SMALL MOLECULE INHIBITORS TO KLF10 FOR MODULATION OF T REGULATORY CELLS AND CANCER IMMUNOTHERAPY

The invention relates to compositions and methods for inhibiting Krüppel-like Factor 10 (KLF10) for modulation of T regulatory cells and cancer immunotherapy. 6. A method of modulating an immune response claim 1 , comprising: administering to a subject an effective amount of an inhibitor of KLF10 claim 1 , wherein the inhibitor of KLF10 is a compound of .7. A method of modulating an immune response claim 2 , comprising: administering to a subject an effective amount of an inhibitor of KLF10 claim 2 , wherein the inhibitor of KLF10 is a compound of .8. A method of modulating an immune response claim 3 , comprising: administering to a subject an effective amount of an inhibitor of KLF10 claim 3 , wherein the inhibitor of KLF10 is a compound of .9. A composition claim 1 , comprising: an effective amount of an inhibitor of KLF10 to decrease T regulatory (T reg) cells at a tumor site or a pathogen infected area of a subject claim 1 , wherein the inhibitor of KLF10 is a compound of .10. A composition claim 2 , comprising: an effective amount of an inhibitor of KLF10 to decrease T regulatory (T reg) cells at a tumor site or a pathogen infected area of a subject claim 2 , wherein the inhibitor of KLF10 is a compound of .11. A composition claim 3 , comprising: an effective amount of an inhibitor of KLF10 to decrease T regulatory (T reg) cells at a tumor site or a pathogen infected area of a subject claim 3 , wherein the inhibitor of KLF10 is a compound of .12. A composition claim 1 , comprising: an effective amount of an inhibitor of KLF10 to decrease T regulatory (T reg) cells at a tumor site or a pathogen infected area of a subject in combination with one or more disease antigens claim 1 , wherein the inhibitor of KLF10 is a compound of .13. A composition claim 2 , comprising: an effective amount of an inhibitor of KLF10 to decrease T regulatory (T reg) cells at a tumor site or a pathogen infected area of a subject in combination with one or more disease antigens claim 2 , ...

PROCESS FOR PREPARING A MACROCYCLIC DIKETONE

The present invention relates to a process for preparing a macrocyclic diketone compound of the formula (I), which comprises the oxidation of a bicycloolefine compound of the formula (II) with an oxidizing agent, formulae (I) (II) where in formulae (I) and (II) A is (CH)with n being an integer from 2 to 12, where two hydrogen atoms may be replaced by C-C-alkyl, in particular methyl, or two hydrogen atoms, which are bound to adjacent carbon atoms may be replaced by a fused 5- or 6-membered saturated carbocycle; B is (CH)with m being 1 or 2, where 1 or 2 hydrogen atoms may be replaced by C-C-alkyl, in particular methyl. 114.-. (canceled)16. The process of claim 15 , where the total amount of the ruthenium compound in the reaction mixture claim 15 , calculated based on the number of ruthenium atoms claim 15 , is in the range of from 0.001 to 0.2 mol per 1 mol of compound of formula (II).17. The process of claim 15 , where the ruthenium compound is selected from the group consisting of ruthenium oxides claim 15 , ruthenates claim 15 , perruthenates claim 15 , ruthenium halides claim 15 , ruthenium nitrates and mixtures thereof.18. The process of claim 15 , where the total amount of the co-oxidizing agent used in the oxidation is in the range of from 2 to 10 mol per 1 mol of compound of formula (II) claim 15 , calculated as oxygen equivalent.19. The process of claim 15 , where the co-oxidizing agent is selected from hypochlorites.20. The process of claim 15 , where the pH of the reaction mixture is maintained in the range of from 7 to 14 during the oxidation of the compound of formula (II).21. The process of claim 20 , where the maintenance of the pH is achieved by adding an aqueous buffer solution claim 20 , comprising at least one buffering agent claim 20 , having a pKa-value in the range of from 8 to 12 claim 20 , to the reaction mixture.22. The process of claim 15 , where the co-oxidizing agent is added to the reaction mixture in the form of an alkaline aqueous ...

Compounds and compositions for biofilm prevention

The present invention relates to compounds and compositions for effective biofilm prevention. Particularly, the invention provides compositions comprising certain cyclic ketones found to be efficient in preventing bacterial biofilm formation.

Oxocarbon-, Pseudooxocarbon- and Radialene Compounds and Their Use

The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds as well as to their use as doping agent for doping an organic semiconductive matrix material, as blocker material, as charge injection layer, as electrode material as well as organic semiconductor, as well as electronic components and organic semiconductive materials using them. 2. The electronic component as claimed in claim 1 , wherein Y is perfluoroalkyl.3. The electronic component as claimed in claim 2 , wherein the perfluoroalkyl is CF.4. The electronic component as claimed in claim 1 , wherein the aryl is partially or completely fluorinated.5. The electronic component as claimed in claim 1 , wherein the hetaryl is selected from pyridyl claim 1 , pyrimidyl claim 1 , triazine claim 1 , or oxadiazole.6. The electronic component as claimed in claim 1 , wherein R-Rare independently selected from perhalogenated and/or partially halogenated alkyl groups.7. The electronic component as claimed in claim 6 , wherein R-Rare independently selected from perfluorinated alkyl groups.8. The electronic component as claimed in claim 1 , in the form of an organic light emitting diode claim 1 , a photovoltaic cell claim 1 , an organic solar cell claim 1 , an organic diode claim 1 , or an organic field effect transistor.9. The electronic component as claimed in claim 1 , wherein hetaryl is the substituted or unsubstituted aromatic heterocyclic compound or biheteroaryl claim 1 , and hetaryl is electron-deficient. This application is a divisional of U.S. patent application Ser. No. 15/817,398, filed Nov. 20, 2017, which is a divisional of U.S. patent application Ser. No. 14/570,443, filed Dec. 15, 2014, now U.S. Pat. No. 9,876,172, which is a divisional of U.S. patent application Ser. No. 14/080,340, filed Nov. 14, 2013, now U.S. Pat. No. 8,911,645, which is a divisional of U.S. patent application Ser. No. 13/178,855, filed Jul. 8, 2011, now U.S. Pat. No. 8,617,426, which is a divisional of U.S. ...

Cycloalkane Oxidation Catalysts and Method to Produce Alcohols and Ketones

Disclosed is a method of oxidizing a cycloalkane to form a product mixture containing a corresponding alcohol and ketone, said method comprising contacting a cycloalkane with a hydroperoxide in the presence of a catalytic effective amount of a crystalline MWW-type titanosilicate catalyst. Hydroperoxides may notably be tert-butyl hydroperoxide, tert-amyl hydroperoxide, cumene hydroperoxide, ethylbenzene hydroperoxide, cyclohexyl hydroperoxide, methylcyclohexyl hydroperoxide, tetralin hydroperoxide, isobutylbenzene hydroperoxide, and ethylnaphthalene hydroperoxide. 1. A method of oxidizing a cycloalkane to form a product mixture containing a corresponding alcohol and ketone , said method comprising contacting a cycloalkane with a hydroperoxide in the presence of a catalytically effective amount of a crystalline MWW-type titanosilicate catalyst.2. A method according to claim 1 , in which the hydroperoxide is chosen in the group consisting of: tert-butyl hydroperoxide claim 1 , tert-amyl hydroperoxide claim 1 , cumene hydroperoxide claim 1 , ethylbenzene hydroperoxide claim 1 , cyclohexyl hydroperoxide claim 1 , methylcyclohexyl hydroperoxide claim 1 , tetralin claim 1 , isobutylbenzene hydroperoxide claim 1 , and ethylnaphthalene hydroperoxide.3. A method according to claim 1 , in which the hydroperoxide is added to the cycloalkane at the start of the step of contacting.4. A method according to claim 1 , in which the hydroperoxide is generated in situ by reaction of a cycloalkane with oxygen or an oxygen generator.6. A method according to claim 1 , in which the catalyst further comprises one or more heteroatoms from the group consisting of the elements of Periods IB claim 1 , IVB claim 1 , VB claim 1 , VIB claim 1 , VIIB claim 1 , VIIIB and VA.7. A method according to claim 1 , in which the contacting is at a temperature of between 20 and 200° C.8. A method according to claim 1 , in which pure oxygen claim 1 , air claim 1 , oxygen-enriched air claim 1 , oxygen-depleted ...

NEUROACTIVE SUBSTITUTED CYCLOPENTA[b]PHENANTHRENES AS MODULATORS FOR GABA TYPE-A RECEPTORS

The present disclosure is generally directed to neuroactive substituted cyclopenta[b]phenanthrenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.

1-HYDROXYMETHYL-1,2,2,6-TETRAMETHYL-CYCLOHEXANE AND DERIVATIVES THEREOF AND THEIR USE AS AROMA CHEMICALS

The invention relates to compounds of formula (A) as defined herein, and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to a method for preparing compounds of formula (A) and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to the use of at least one compound selected from compounds of formula (A) and the esters of a compound of formula (A) and the ketones of a compound of formula (A) as aroma chemical. 7. The method according to claim 5 , for preparing a compound of formula (A.b) claim 5 , wherein in step iib) claim 5 , the nucleophilic agent is selected from metal C-C-alkyl compounds and metal C-C-alkenyl compounds claim 5 , which comprise at least one ligand R.10. The use of a compound according to as aroma chemical.13. The perfumed or aromatized product according to claim 12 , wherein the product is preferably selected from scent dispensers and fragrances perfumes claim 12 , detergents and cleaners claim 12 , cosmetic compositions claim 12 , body care compositions claim 12 , hygiene articles claim 12 , products for oral and dental hygiene claim 12 , scent dispensers claim 12 , fragrances claim 12 , pharmaceutical compositions and crop protection compositions. Despite a large number of existing aroma chemicals (fragrances and flavorings), there is a constant need for new components in order to be able to satisfy the multitude of properties desired for extremely diverse areas of application. These include, firstly, the organoleptic properties, i.e. the compounds should have advantageous odiferous (olfactory) or gustatory properties. Furthermore, aroma chemicals should, however, also have additional positive secondary properties, such as e.g. an efficient preparation method, the possibility of providing better sensory profiles as a result of synergistic effects with other fragrances, a higher stability under certain application ...

Chemical liquid purification method and chemical liquid

An object of the present invention is to provide a chemical liquid purification method which makes it possible to obtain a chemical liquid having excellent defect inhibition performance. Another object of the present invention is to provide a chemical liquid. The chemical liquid purification method according to an embodiment of the present invention is a chemical liquid purification method including obtaining a chemical liquid by purifying a substance to be purified containing an organic solvent, in which a content of the stabilizer in the substance to be purified with respect to the total mass of the substance to be purified is equal to or greater than 0.1 mass ppm and less than 100 mass ppm.

PROCESS FOR PREPARING 3-METHYLCYCLOPENTADECANE-1,5-DIONE

The present invention relates to a process for producing 3-methylcyclopentadecane-1,5-dione of formula (I), which comprises the oxidation of 14-methyl-bicyclo[10.3.0]pentadecen[1 (12)] of formula (II) with an oxidizing agent, where the oxidation is performed by using a mixture of formic acid with HOas sole oxidizing agent in the presence of water and where the amount of HOis at least 1.1 mol HOper mol of the compound of formula (II). 111.-. (canceled)12. A process for preparing 3-methylcyclopentadecane-1 ,5-dione , which comprises oxidizing 14-methylbicyclo[10.3.0]pentadecen[1(12)] with an oxidizing agent , where the oxidation is performed by using a mixture of formic acid with HOas sole oxidizing agent in the presence of water and where the amount of HOis at least 1.1 mol HOper mol of 14-methylbicyclo[10.3.0]pentadecen[1(12)].13. The process of claim 12 , wherein the amount of HOis from 1.4 to 4.0 mol HOper mol of 14-methylbicyclo[10.3.0]pentadecen[1(12)].14. The process of claim 12 , wherein the amount of HOis from 15 to 3.5 mol HOper mol of 14-methylbicyclo[10.3.0]pentadecen[1(12)].15. The process of claim 12 , wherein HOis added to the mixture of 14-methylbicyclo[10.3.0]pentadecen[1(12)] and formic acid.16. The process of claim 14 , wherein the total amount of added HOis added over a period of at least 2 h.17. The process of claim 14 , wherein the total amount of added HOis added over a period of from 2 to 24 h.18. The process of claim 14 , wherein less than 70% of the total amount of HOused in the process is present at the beginning of the oxidation.19. The process of claim 14 , wherein less than 70% and at most 50% of the total amount of HOused in the process is present at the beginning of the oxidation20. The process of claim 16 , wherein at least 50% of the total amount of HOare added to the reaction mixture while the oxidation reaction takes place.21. The process of claim 12 , wherein the oxidation of the compound of 14-methylbicyclo[10.3.0]pentadecen[1(12 ...

METHOD OF PRODUCING ORGANIC COMPOUND

A method of producing an organic compound, which contains a step of performing a deodorization step using a flow reaction in a flow passage to remove, from a reaction liquid, a malodorous material generated or remaining in a reaction step, 1. A method of producing an organic compound , comprising:performing a deodorization using a flow reaction in a flow passage to remove, from a reaction liquid, a malodorous material generated or remaining in a reaction,wherein the organic compound is an industrially useful compound.2. The production method according to claim 1 , wherein the reaction is an oxidation reaction using a sulfur atom-containing organic compound.3. The production method according to claim 1 , wherein claim 1 , in the reaction claim 1 , an alcohol compound having 2 to 50 carbon atoms is oxidized to produce an aldehyde or ketone compound having 2 to 50 carbon atoms.4. The production method according to claim 2 , wherein the oxidation reaction using a sulfur-atom-containing organic compound is an oxidation reaction using a dialkyl sulfoxide compound having 2 to 8 carbon atoms claim 2 , and an acid anhydride having 4 to 10 carbon atoms or an acid halide having 2 to 7 carbon atoms.5. The production method according to claim 1 , wherein the malodorous material is a dialkyl sulfide having 2 to 8 carbon atoms.6. The production method according to claim 1 , wherein the deodorization is an oxidation reaction of the malodorous material.7. The production method according to claim 1 , wherein the deodorization is an oxidation reaction in which the malodorous material is oxidized by using an oxidizing agent selected from the group consisting of hypochlorous acid or a salt thereof claim 1 , a halogenating agent claim 1 , and peracetic acid.8. The production method according to claim 7 , wherein an amount of the oxidizing agent is 0.5 to 5.0 molar equivalents claim 7 , based on an amount of the acid anhydride or the acid halide in the reaction.9. The production method ...

ELECTRONIC APPARATUS

Provided is an electronic apparatus including: a substrate; a pixel defined layer defining a plurality of pixel areas and a plurality of non-pixel areas on the substrate; a plurality of light-emitting diodes arranged on the plurality of the pixel areas; and a thin film encapsulation portion including an organic film and sealing the pixel defined layer, or the plurality of the light-emitting diodes and the pixel defined layer, wherein the organic film includes a curable material of a composition for forming an organic film, the composition including at least one UV absorber. 1. An electronic apparatus comprising:a substrate;a pixel defined layer defining a plurality of pixel areas and a plurality of non-pixel areas on the substrate;a plurality of light-emitting diodes arranged on the plurality of the pixel areas; anda thin film encapsulation portion comprising an organic film and sealing the pixel defined layer or both the plurality of the light-emitting diodes and the pixel defined layer,wherein the organic film comprises a cured product of a composition for forming an organic film, the composition comprising a curable material and an ultraviolet (UV) absorber, andwherein the curable material comprises a (meth)acrylate compound.2. The electronic apparatus of claim 1 , wherein the plurality of the light-emitting diodes are arranged on the substrate to be surrounded by the pixel defined layer.3. The electronic apparatus of claim 1 , wherein:thin film encapsulation portion further comprises at least one inorganic film, andthe thin film encapsulation portion comprises a sealing unit in which the organic film and the inorganic film are stacked, in the number of n, n being an integer of 1 or more.4. The electronic apparatus of claim 3 , wherein the inorganic film comprises at least one selected from a metal claim 3 , a metal halide claim 3 , a metal nitride claim 3 , a metal oxide claim 3 , a metal oxynitride claim 3 , a silicon nitride claim 3 , a silicon oxide claim 3 , ...

NOVEL OCTAHYDROINDENYL PROPANAL COMPOUNDS

The present invention pertains to novel octahydro-indene compounds and their unexpected advantageous use thereof in enhancing, improving or modifying the fragrance of perfumes, colognes, toilet waters, fabric care products, personal products, and the like. 1. A compound selected from the group consisting of:1-(1,1-dimethyl-octahydro-inden-5-yl)-ethanol;1-(3,3-dimethyl-octahydro-inden-5-yl)-ethanol;1-(1,1-dimethyl-octahydro-inden-5-yl)-ethanone;1-(3,3-dimethyl-octahydro-inden-5-yl)-ethanone;1,1-dimethyl-octahydro-inden-5-ol;3,3-dimethyl-octahydro-inden-5-ol;1,1-dimethyl-octahydro-inden-5-one;3,3-dimethyl-octahydro-inden-5-one;1-(1,1,6-trimethyl-octahydro-inden-5-yl)-ethanol;1-(3,3,6-trimethyl-octahydro-inden-5-yl)-ethanol; anda mixture thereof.2. A fragrance formulation containing an olfactory acceptable amount of a compound selected from the group consisting of:1-(1,1-dimethyl-octahydro-inden-5-yl)-ethanol;1-(3,3-dimethyl-octahydro-inden-5-yl)-ethanol;1-(1,1-dimethyl-octahydro-inden-5-yl)-ethanone;1-(3,3-dimethyl-octahydro-inden-5-yl)-ethanone;1,1-dimethyl-octahydro-inden-5-ol;3,3-dimethyl-octahydro-inden-5-ol;1,1-dimethyl-octahydro-inden-5-one;3,3-dimethyl-octahydro-inden-5-one;1-(1,1,6-trimethyl-octahydro-inden-5-yl)-ethanol;1-(3,3,6-trimethyl-octahydro-inden-5-yl)-ethanol; anda mixture thereof.3. The fragrance formulation of claim 2 , wherein the olfactory acceptable amount is from about 0.005 to about 50 weight percent of the fragrance formulation.4. The fragrance formulation of claim 2 , wherein the olfactory acceptable amount is from about 0.5 to about 25 weight percent of the fragrance formulation.5. The fragrance formulation of claim 2 , wherein the olfactory acceptable amount is from about 1 to about 10 weight percent of the fragrance formulation.6. The fragrance formulation of further comprising a material selected from the group consisting of a polymer claim 2 , an oligomer and a non-polymer.7. The fragrance formulation of claim 6 , wherein the non- ...

Use of 1-[(4r)-4-methylcyclohexen-1-yl]ethanone as an aroma chemical

Use of 1-[(4R)-4-methylcyclohexen-1-yl]ethanone to impart a ylang-ylang note to a composition.

NEUROACTIVE SUBSTITUTED CYCLOPENTA[b]PHENANTHRENES AS MODULATORS FOR GABA TYPE-A RECEPTORS

The present disclosure is generally directed to neuroactive substituted cyclopenta[b]phenanthrenes as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds. 120-. (canceled)22. The compound of claim 21 , wherein Ris H.23. The compound of claim 21 , wherein Ris ═O.24. The compound of claim 21 , wherein Ris α-CN.25. The compound of claim 21 , wherein Ris C(O)CH.26. The compound of claim 21 , wherein Ris spiroepoxy.27. The compound of claim 21 , wherein Ris ═O.28. The compound of claim 21 , wherein Ris H.29. The compound of claim 21 , wherein Ris H.30. The compound of claim 21 , wherein Ris H.31. The compound of claim 21 , wherein Ris H.32. The compound of claim 21 , wherein Ris H.33. The compound of claim 21 , wherein Ris methyl.34. The compound of claim 21 , wherein Ris H.35. The compound of claim 21 , wherein Ris H.36. The compound of claim 21 , wherein Ris H.37. The compound of claim 21 , wherein the C—H is in the alpha configuration.40. A pharmaceutical composition comprising the compound of claim 21 , a pharmaceutically acceptable salt thereof claim 21 , or a combination of two or more thereof claim 21 , and a pharmaceutically acceptable carrier. This application is a continuation application and claims priority benefit of U.S. patent application Ser. No. 14/200,219, filed on Mar. 7, 2014 and which claims priority benefit of U.S. Provisional Patent Application Ser. No. 61/776,395, filed on Mar. 11, 2013, the entire contents of which are incorporated herein by reference.This invention was made with Government support under NIH Grant #GM47969, awarded by the National Institute of Health. The Government has certain rights in the invention.The present disclosure is generally directed to novel compounds having utility as an anesthetic and/or ...

METHOD FOR DECREASING THE CONCENTRATION OF A METAL IN A MONOMER COMPOSITION COMPRISING BIS(BENZOYL)BENZENE

Disclosed are methods of decreasing the concentration of a metal in a monomer composition including a bis(benzoyl)benzene, bis(benzoyl)benzene monomer compositions having a low total metal concentration, di-ketone polymers made from low metal bis(benzoyl)benzene monomers, and polymer compositions and shaped articles including the di-ketone polymers. It was surprisingly found that di-ketone polymers made by nucleophilic substitution of low metal bis(benzoyl)benzene monomers exhibit greater crystallinity, as compared with di-ketone polymers made with conventional monomers. 115-: (canceled)17. The method of claim 16 , further comprising:a) dissolving the monomer composition prior to the recrystallizing,{'sub': '1', 'wherein dissolving the monomer composition includes heating the monomer composition in the first solvent (Solvent A) to a first temperature (T) to form a monomer solution;'} the concentration of the monomer composition in the first solvent (Solvent A) ranges from about 10 to about 20 wt. % relative to the combined weight of the monomer composition and the first solvent (Solvent A); and', {'sub': '1', 'the first temperature (T) ranges from about 50 to about 240° C.'}], 'wherein18. The method of claim 16 , wherein recrystallizing the monomer composition comprises:b1) optionally passing the monomer solution through a first filter;{'sub': '2', 'b2) optionally distilling off a portion of the first solvent (Solvent A) at a second temperature (T),'}{'sub': '3', 'b3) optionally adding a second solvent (Solvent B) to the monomer solution when the first solvent (Solvent A) is at a third temperature (T) to form a solvent mixture,'}wherein the solubility of the monomer composition in the solvent mixture is less than the solubility of the monomer composition in the first solvent (Solvent A); and{'sub': 4', '4, 'b4) optionally cooling the monomer solution to a fourth temperature (T) ranging from about −10 to about 40° C., provided that the fourth temperature (T) is ...

PROCESS FOR PREPARING CYCLODODECANONE

The invention relates to a method for producing cyclododecanone (CDON). During the production, contaminated cyclododecane (CDAN) is produced. This can be separated from CDON by distillation (CDAN-containing fraction). The separation of CDAN and impurities such as 13-oxabicyclo [7.3.1]tridacane occurs by crystallizing out CDAN from the CDAN-containing fraction. 1. A process for producing cyclododecanone (CDON) comprising the consecutive steps of:a) reaction of 1,5,9-cyclododecatriene (CDT) to afford a mixture of cyclododecanol (CDOL) and CDON,b) dehydrogenation of the CDOL to afford CDON, wherein a CDON-containing mixture which comprises cyclododecane (CDAN) is obtained,c) distillation of the CDON-containing mixture to obtain a fraction comprising CDAN (CDAN-containing fraction) and a CDON-containing fraction, andd) crystallizing-out CDAN from the CDAN-containing fraction.2. The process according to claim 1 , wherein the CDAN-containing fraction contains impurities which comprise 13-oxabicyclo[8.2.1]tridecane claim 1 , 13-oxabicyclo[7.3.1]tridecane claim 1 , 2-undecanone or mixtures thereof.3. The process according to claim 2 , wherein the impurity comprises 13-oxabicyclo[7.3.1]tridecane.4. The process according to claim 1 , wherein the mixture of CDOL and CDON is obtained by the consecutive steps ofi) hydrogenation of CDT to afford CDAN andii) oxidation of CDAN to afford the mixture of CDOL and CDON.5. The process according to claim 1 , wherein the mixture of CDOL and CDON is obtained by the consecutive steps ofI) hydrogenation of CDT to afford cyclododecene (CDEN),II) epoxidation of CDEN to afford cyclododecane epoxide (CDAN epoxide) andIII) rearrangement of CDAN epoxide to afford the mixture of CDOL and CDON.6. The process according to claim 1 , wherein the crystallized-out CDAN (step d) is oxidized to afford a mixture of CDOL and CDON.7. The process according to claim 1 , wherein the crystallized-out CDAN (step d) is converted into cyclododecanone oxime with ...

METHOD FOR PRODUCING CYCLIC DIKETONE COMPOUND

Provided is a method for producing a compound represented by general formula (I) by oxidative cleavage of a compound of formula (II), which is a bicyclic tetrasubstituted olefin compound, using hydrogen peroxide. The method for producing a compound represented by general formula (I) includes a step of subjecting a compound represented by general formula (II) to oxidative cleavage using hydrogen peroxide in the presence of an acid catalyst or in the presence of a tungstic acid compound to obtain the compound represented by general formula (I): 2. The method for producing a compound represented by general formula (I) according to claim 1 , wherein{'sup': '1', 'Ais an alkylene group having 3 or 4 carbon atoms that is optionally substituted, and'}{'sup': '2', 'Ais an alkylene group having 4, 6, 8, or 10 carbon atoms that is optionally substituted.'}3. The method for producing a compound represented by general formula (I) according to claim 1 , whereinthe oxidative cleavage is in the presence of the acid catalyst, which is at least one selected from the group consisting of Bronsted acid and Lewis acid.4. The method for producing a compound represented by general formula (I) according to claim 3 , whereinthe Bronsted acid is a Bronsted acid having a pKa (in water) of not more than 2.0.5. The method for producing a compound represented by general formula (I) according to claim 3 , whereinthe Bronsted acid is sulfuric acid, phosphoric acid, trifluoroacetic acid, or p-toluenesulfonic acid.6. The method for producing a compound represented by general formula (I) according to claim 1 , whereinthe oxidative cleavage is in the presence of the tungstic acid compound, which is tungstic acid, isopolytungstic acid, or heteropolytungstic acid.7. The method for producing a compound represented by general formula (I) according to claim 6 , wherein{'sub': 2', '4', '6', '2', '12', '40', '6', '10', '12', '46', '3', '12', '40', '2, 'the tungstic acid is orthotungstic acid (HWO), ...

Sacubitril intermediate and preparation method thereof

The present invention relates to a sacubitril intermediate and a preparation method thereof. The sacubitril intermediate disclosed herein can be prepared by a deprotection reaction of a compound. In addition, the intermediate can be used as a raw material to synthesize sacubitril. The method disclosed herein has advantages of easily obtained raw materials, simple preparation process, low cost, environment friendly, and etc., which is very suitable for industrial production.

SUPPORTED INTERMETALLIC COMPOUNDS AND USE AS CATALYST

A composition comprising a ternary intermetallic compound XYZ, wherein X, Y, and Z are different from one another; X being selected from the group consisting of Mn, Fe, Co, Ni, Cu, and Pd; Y being selected from the group consisting of Cr, Co, and Ni; and Z being selected from the group consisting of Al, Si, Ga, Ge, In, Sn, Zn, and Sb; wherein the ternary intermetallic compound is supported on a porous oxidic support material. The composition may be prepared by providing a liquid mixture of sources of X, Y, and Z, and the porous oxidic support material, removing the liquid and heating the resulting mixture in a reducing atmosphere. The composition is useful as catalyst. 1: A composition comprising a ternary intermetallic compound XYZ , whereinX, Y, and Z are different from one another;X being selected from the group consisting of Mn, Fe, Co, Ni, Cu, and Pd;Y being selected from the group consisting of Cr, Co, and Ni; andZ being selected from the group consisting of Al, Si, Ga, Ge, In, Sn, Zn, and Sb;wherein the ternary intermetallic compound is supported on a porous oxidic support material.2: The composition of claim 1 , wherein the porous oxidic support material comprises one or more selected from the group consisting of:silica,alumina,titania,zirconia, anda mixed oxide of one or more selected from the group consisting of Si, Al, Ti, and Zr.3: The composition of claim 1 , wherein X or Y is Co claim 1 , and wherein Z is selected from the group consisting of Al claim 1 , Ga claim 1 , In claim 1 , and Zn.4: The composition of claim 1 , wherein the porous oxidic support material comprises a mixed oxide of Si and Al.5: The composition of claim 1 , wherein in the composition claim 1 , the weight ratio of the ternary intermetallic compound relative to the porous oxidic compound is in the range of from 0.5:99.5 to 30:70.6: The composition of claim 1 , wherein Y is Ni claim 1 , and wherein Z is Al claim 1 , Si claim 1 , Ga claim 1 , In claim 1 , Sn claim 1 , or Sb.7: The ...

Process for the preparation of enantiomerically and diastereomerically enriched cyclobutane amines and amides

The present invention relates to a process for the preparation of enantiomerically and diastereomerically enriched cyclobutane amines and amides by reacting (a) cyclopropylcarbonitrile to a cyclopropylcarbaldehyde, (b) further reacting to a cyclobutanone, or (d) further reacting to an enamide, 5 (c) further reacting to enantiomerically and diastereomerically enriched cyclobutane amines, or (d) further reacting to an enamide and (e) to an enantiomerically and diastereomerically enriched cyclobutylamide to obtain (f) an enantiomerically and diastereomerically enriched cyclobutane amine, and (g) further reacting to an enantiomerically and diastereomerically enriched cyclobutane amide.

Oxocarbon, pseudo oxocarbon and radialene compounds and their use

As organic doping agent for the doping of an organic semiconductive matrix material, as blocker layer, as charge injection layer or as organic semiconductor itself, an organic mesomeric compound, which is an oxocarbon, pseudooxocarbon or radialene compound, is used. As organic doping agent for the doping of an organic semiconductive matrix material, as blocker layer, as charge injection layer or as organic semiconductor itself, an organic mesomeric compound, which is an oxocarbon, pseudooxocarbon or radialene compound of formula (I), is used. n : 1-4; X 1-X 5C(CN) 2, (CF 3)C(CN), (NO 2)C(CN), C(halogen) 2, C(CF 3) 2, NCN, O, S, NR 1, groups of formulae (Ia)-(Iq), R 1-C(=X 4)-CH 2-C(=X 5)-R 2, R 1-C(=X 4)-CH 2-CN, Aryl-CH 2-Aryl, Aryl-CH 2-Y 1, Hetaryl-CH 2-Hetaryl, Hetaryl-CH 2-Y 1, R 1-C(=X 4)-CH 2-CF 3, ArO 2S-CH 2-CF 3, HetarylO 2S-CH 2-CF 3, HetarylO 2S-CH 2-CN, or ArO 2S-CH 2-CN; Y 1CN, NO 2, COR 1 or perhalogenated alkyl; aryl or Ar : optionally substituted aromatic hydrocarbon or biaryl, or optionally polycyclic; Hetaryl : optionally substituted aromatic heterocyclic compound or biheteroaryl, preferably electron-poor, optionally polynuclear or partially or completely hydrogenated or fluorinated;and R 1-R 8H, halo, CN, NO 2, COR 1, alkyl, alkoxy, aryl or heteroaryl. The aryl is partially or completely hydrogenated or fluorinated. Independent claims are included for the following: (1) new oxocarbon, pseudooxocarbon or radialene compounds of formula (I), their radical anionic salts, dianionic salts or charge transfer complexes with donors; (2) organic semiconductive material containing at least one organic matrix compound and one doping agent, where the doping agent is at least one oxocarbon, pseudooxocarbon or radialene compound; and (3) electronic component with an electronically functionally active area, where the electronically functionally active area is produced using at least one oxocarbon, pseudooxocarbon or radialene compounds. Provided that: (1) When n ...

Process for producing alpha-hydroxyketones

Oxocarbon-, pseudooxocarbon- and radialene compounds and their use

본 발명은 옥소카본-, 유사옥소카본- 및 라디알렌 화합물, 및 유기 반도체 매트릭스 물질을 도핑하기 위한 도핑제로서, 차단 물질로서, 전하 주입층으로서, 전극 물질로서 및 유기 반도체로서의 이들의 용도, 및 이들을 이용한 전자 부품 및 유기 반도체 물질에 관한 것이다. The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds, and their use as dopants for doping organic semiconductor matrix materials, as blocking materials, as charge injection layers, as electrode materials and as organic semiconductors, and It relates to electronic components and organic semiconductor materials using them.

Method for the production of 1.7-octadiene and use thereof

The invention relates to a method for the production of 1.7 octadiene by reacting metathesis of cyclohexene with ethylene. The invention also relates to the production of 1.10-decandiol by hydroformulating 1.7 octadiene produced according to said method. The invention further relates to a method for the production of muscone or olefinically unsaturated analogs thereof using 1.10 decandiol which is obtainable in said manner.

Oxocarbon-, pseudooxocarbon- and radialene compounds and their use

본 발명은 옥소카본-, 유사옥소카본- 및 라디알렌 화합물, 및 유기 반도체 매트릭스 물질을 도핑하기 위한 도핑제로서, 차단 물질로서, 전하 주입층으로서, 전극 물질로서 및 유기 반도체로서의 이들의 용도, 및 이들을 이용한 전자 부품 및 유기 반도체 물질에 관한 것이다. The present invention relates to dopants for doping oxocarbon-, pseudooxocarbon- and radialene compounds, and organic semiconductor matrix materials, as blocking materials, as charge injection layers, as electrode materials and their use as organic semiconductors, and And electronic components and organic semiconductor materials using these materials.

Oxocarbon-, pseudooxocarbon- and radialene compounds and their use

본 발명은 옥소카본-, 유사옥소카본- 및 라디알렌 화합물, 및 유기 반도체 매트릭스 물질을 도핑하기 위한 도핑제로서, 차단 물질로서, 전하 주입층으로서, 전극 물질로서 및 유기 반도체로서의 이들의 용도, 및 이들을 이용한 전자 부품 및 유기 반도체 물질에 관한 것이다. The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds, and their use as dopants for doping organic semiconductor matrix materials, as blocking materials, as charge injection layers, as electrode materials and as organic semiconductors, and It relates to electronic components and organic semiconductor materials using them.

Oxocarbon-, pseudooxocarbon- and radialene compounds and their use

본 발명은 옥소카본-, 유사옥소카본- 및 라디알렌 화합물, 및 유기 반도체 매트릭스 물질을 도핑하기 위한 도핑제로서, 차단 물질로서, 전하 주입층으로서, 전극 물질로서 및 유기 반도체로서의 이들의 용도, 및 이들을 이용한 전자 부품 및 유기 반도체 물질에 관한 것이다. The present invention relates to oxocarbon-, pseudooxocarbon- and radialene compounds, and their use as dopants for doping organic semiconductor matrix materials, as blocking materials, as charge injection layers, as electrode materials and as organic semiconductors, and It relates to electronic components and organic semiconductor materials using them.

Patent JPS4948638A

Preparation of cyclobutanones from glutaric anhydrides

THE PREPARATION OF CYCLOBUTANONES FROM GLUTARIC ANHYDRIDES BY MEANS OF PHOTOLYSIS AT A TEMPERATURE OF FROM ABOUT 120 TO ABOUT 300*C.

Sphyngosine kinase inhibitors

FIELD: medicine, pharmaceutics. SUBSTANCE: present invention refers to new compounds of formula I or their pharmaceutically acceptable salts showing an ability to inhibit sphingosine kinase, to a based pharmaceutical composition, to a method of inhibiting sphingosine kinase and a method of treating diseases specified in breast cancer, diabetic retinopathy, arthritis and colitis. , wherein X represents -C(R 3 ,R 4 )N(R 5 )-, -C(O)N(R 4 )-; R 1 represents phenyl unsubstituted or substituted by 1 or 2 halogens. The values of R 2 , R 3 , R 4 , R 5 substitutes are such as specified in the patent claim. EFFECT: preparation of new compounds. 17 cl, 24 dwg, 9 tbl, 26 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 447 060 (13) C2 (51) МПК C07C C07C C07C C07C C07D C07D C07D ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИC07D C07D C07D 233/57 255/44 317/32 323/23 317/58 207/02 295/13 295/32 213/24 265/30 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) C07D C07D C07D C07D C07D C07D C07D A61K A61K A61K 233/54 (2006.01) 277/46 (2006.01) 263/58 (2006.01) 277/82 (2006.01) 257/04 (2006.01) 209/88 (2006.01) 473/34 (2006.01) 31/33 (2006.01) 31/16 (2006.01) 31/13 (2006.01) (см. прод.) (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ Приоритет(ы): (30) Конвенционный приоритет: 17.06.2005 US 60/691,563 (73) Патентообладатель(и): ЭПОУДЖИ БИОТЕКНОЛОДЖИ КОРПОРЕЙШН (US) 2 4 4 7 0 6 0 (43) Дата публикации заявки: 27.07.2009 Бюл. № 21 2 4 4 7 0 6 0 R U (56) Список документов, цитированных в отчете о поиске: US 4053509 А, 11.10.1977. US 5595995 А, 21.01.1997. US 4332806 А, 01.06.1982. US 3663565 A, 16.05.1972. US 4349552 A, 14.09.1982. US 6649600 B1, 18.11.2003. US 3657273 A, 18.04.1972. WO 99/26927 A2, 03.06.1999. WO 2004/089470 A2, 21.10.2004. SU 1574586 A1, 30.06.1990. SU 1367194 A1, 10.04.1996. RU 2197467 C2, 27.01.2003. SU 451691 A, 09.07.1975. (см. прод.) C 2 C 2 (45) Опубликовано: 10.04.2012 Бюл. № 10 (85) Дата начала рассмотрения заявки PCT на ...

The synthetic method of prothioconazoles intermediate 1 chlorine 1 acetylcyclopropane

丙硫菌唑中间体1‑氯‑1‑乙酰基环丙烷的合成方法，涉及化工生产技术领域，将乙酰乙酸烷基酯和1,2‑二卤代烷或乙二醇二磺酸酯混合进行单烷基化反应，再经氯化反应后，再与强酸混合进行水解，取得3,5‑二氯戊烷‑2‑酮或3‑氯‑4‑磺酸酯基戊烷‑2‑酮；最后以季铵盐为催化剂，将3,5‑二氯戊烷‑2‑酮或3‑氯‑4‑磺酸酯基戊烷‑2‑酮和碱液混合进行关环反应，取得1‑氯‑1‑乙酰基环丙烷。本发明降低了成本，减少三废，安全可靠，反应收率高。

Derivative of bicyclo-octanes class, preparation method, and application of medicine

本发明涉及一种通式(I)所示的新的双环辛烷类衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂特别是作为二肽基肽酶抑制剂(DPPIV)的用途，其中通式(I)中的各取代基同说明书中的定义相同。

Method of obtaining benzilaminoalkane acids or salts thereof

Fluorene compound, light-emitting element, light-emitting device, electronic device, lighting device and organic compound

本发明的一个方式的目的之一是提供一种具有空穴传输性，并且其带隙宽的物质。提供由通式(G1)表示的芴化合物。在通式(G1)中，α 1 及α 2 分别独立地表示取代或未取代的碳数为6至13的亚芳基，Ar 1 表示取代或未取代的碳数为6至18的芳基、取代或未取代的4-二苯并噻吩基或取代或未取代的4-二苯并呋喃基，n及k分别独立地表示0或1，Q 1 表示硫或氧，R 1 至R 15 分别独立地表示氢、碳数为1至12的烷基或碳数为6至14的芳基。

Cycloalkane oxidation catalysts and method to produce alcohols and ketones

사이클로알칸을 상응하는 알코올 및 케톤이 함유된 생성물 혼합물로 산화시키는 방법을 개시하며, 상기 방법은 사이클로알칸을 촉매 유효량의 결정성 MWW-유형 규산티타늄 촉매의 존재 하에 하이드로퍼옥사이드와 접촉시키는 단계를 포함한다. 하이드로퍼옥사이드는 특히 tert-부틸 하이드로퍼옥사이드, tert-아밀 하이드로퍼옥사이드, 쿠멘 하이드로퍼옥사이드, 에틸벤젠 하이드로퍼옥사이드, 사이클로헥실 하이드로퍼옥사이드, 메틸사이클로헥실 하이드로퍼옥사이드, 테트랄린 하이드로퍼옥사이드, 이소부틸벤젠 하이드로퍼옥사이드, 및 에틸나프탈렌 하이드로퍼옥사이드일 수 있다. Which process comprises contacting a cycloalkane with a hydroperoxide in the presence of a catalytically effective amount of a crystalline MWW-type titanium silicate catalyst, the process comprising contacting the cycloalkane with a product mixture containing a corresponding alcohol and ketone do. Hydroperoxides are especially preferred for use in the process of the present invention, such as tert-butyl hydroperoxide, tert-amyl hydroperoxide, cumene hydroperoxide, ethylbenzene hydroperoxide, cyclohexyl hydroperoxide, methylcyclohexyl hydroperoxide, Isobutyl benzene hydroperoxide, and ethyl naphthalene hydroperoxide.

Tricycloundecane derivatives

Cycloalkane oxidation catalyst and method of producing alcohols and ketones

Настоящее изобретение относится к способу окисления циклоалкана с образованием смеси продуктов, содержащей соответствующие спирт и кетон, включающему контактирование циклоалкана с гидропероксидом в присутствии каталитически эффективного количества кристаллического титаносиликатного катализатора MWW-типа. Предлагаемый способ позволяет повысить степень превращения исходного циклоалкана и селективность по целевым продуктам при использовании катализатора, обладающего высокой окислительной способностью. 8 з.п. ф-лы, 1 табл., 2 пр. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (51) МПК C07C 27/16 C07C 29/48 C07C 45/28 C07C 35/08 C07C 49/403 (13) 2 583 055 C1 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ (21)(22) Заявка: ИЗОБРЕТЕНИЯ К ПАТЕНТУ 2015106498/04, 26.07.2012 (24) Дата начала отсчета срока действия патента: 26.07.2012 (45) Опубликовано: 10.05.2016 Бюл. № 13 (73) Патентообладатель(и): РОДИА ОПЕРАСЬОН (FR), ЭКОЛЬ НОРМАЛЬ СЮПЕРЬЕР ДЕ ЛИОН (FR), ИСТ ЧАЙНА НОРМАЛ ЮНИВЕРСИТИ (CN) (85) Дата начала рассмотрения заявки PCT на национальной фазе: 26.02.2015 2 5 8 3 0 5 5 (56) Список документов, цитированных в отчете о поиске: CN 102452895A, 16.05.2012 . CN 101733164A, 16.06.2010 . WO 2002028774A2, 11.04.2002 . Peng Wu et al, Unique transSelectivity of Ti-MWW in Epoxidation of cis/ trans-Alkenes with Hydrogen Peroxide. J.Phys.Chem.B, 2002, 106(4), 748-753. RU 2280638C2, 27.07.2006 . R U Приоритет(ы): (22) Дата подачи заявки: 26.07.2012 (72) Автор(ы): ДЕКАМПО Флориан (CN), ЧЖОУ Вэньцзюань (CN), У Пэн (CN), СЮЭ Кай (CN), ЛЮ Юэмин (CN), ХЭ Минюань (CN) 2 5 8 3 0 5 5 R U CN 2012/079172 (26.07.2012) C 1 C 1 (86) Заявка PCT: (87) Публикация заявки PCT: WO 2014/015491 (30.01.2014) Адрес для переписки: 129090, Москва, ул. Б. Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" (54) КАТАЛИЗАТОР ОКИСЛЕНИЯ ЦИКЛОАЛКАНОВ И СПОСОБ ПОЛУЧЕНИЯ СПИРТОВ И КЕТОНОВ (57) Реферат: Настоящее изобретение относится к ...

Process for producing large cyclic ketone and intermediate therefor

2-시클로펜타데세논의 1,4-공역 메틸 부가 반응에 의한 무스콘의 제조 방법에 있어서, 극저온이나 저농도의 반응 조건에 따르는 일 없이, 실용적인 조건하에 서 고수율로 무스콘을 제조하는 방법을 제공한다. Provided is a method for producing a mousse cone by the 1,4-conjugated methyl addition reaction of 2-cyclopentadecenone in a high yield under practical conditions without being subjected to cryogenic or low concentration reaction conditions. do. 본 발명의 방법은, 2-시클로펜타데세논에, 구리 촉매 또는 니켈 촉매 및 에놀음이온 포착제의 존재 하, 메틸화 유기 금속 시약에 의해, 1,4-공역 부가 반응을 행하고, 일반식(Ⅱ): In the method of the present invention, 1,4-conjugated addition reaction is carried out to 2-cyclopentadecenone with a methylated organometallic reagent in the presence of a copper catalyst or a nickel catalyst and an enol anion scavenger, and is represented by the general formula (II). ): 으로 나타나는 3-메틸-1-시클로펜타데센 유도체를 얻고, 다음에, 이 3-메틸-1-시클로펜타데센 유도체의 에놀부를 가용매 분해함으로써, 무스콘을 얻는다. The 3-methyl-1-cyclopentadecene derivative shown by this is obtained, Next, a muscon is obtained by solvolysis of the enol part of this 3-methyl-1-cyclopentadecene derivative.

Novel herbicides

Resolution process for preparing l-muscone or d-muscone

본 발명은 합성 d,l-무스콘 라세미체로부터 l-무스콘 또는 d-무스콘을 순수하게 분리 정제하는 방법에 관한 것이다. 더욱 상세하게는, 합성 d,l-무스콘 라세미체로부터 중간체인 d,l-3-메틸-시클로펜타데칸-1 온 L-스레이톨 케탈 혼합 화합물 또는 d,l-3-메틸-시클로펜타데칸-1 온 D-스레이톨 케탈 혼합 화합물을 합성한 후, 이를 재결정화시키고 가수분해시켜 광학활성을 지니는 고순도의 l-무스콘 또는 d-무스콘을 분리 정제하는 방법에 관한 것이다.

Cycloalkane oxidation catalysts and method to produce alcohols and ketones

本发明涉及一种氧化环烷烃来形成含有相应的醇和酮的产品混合物的方法，所述方法包括在催化有效量的晶态的MWW型钛硅酸盐催化剂的存在下将环烷烃与氢过氧化物接触。氢过氧化物可以值得注意地是叔丁基氢过氧化物、叔戊基氢过氧化物、枯烯氢过氧化物、乙基苯氢过氧化物、环己基氢过氧化物、甲基环己基氢过氧化物、四氢化萘、异丁基苯氢过氧化物、以及乙基萘氢过氧化物。

Cyclic ketones, their preparation and their use in the synthesis of amino acids

A method is provided for making an enantiomerically pure of the formula: in which R and R′ represent C1?C10 alkyl, C2?C10 alkenyl or C3?C10 cycloalkyl and the wedges signify (S)- or (R)-stereochemistry, the substituents in compound (II) being trans. Conjugate addition is carried out between an organometallic nucleophile that provides a group R as defined above and (R)-4-acetoxycyclopent-2-en-1-one, (S)-4-acetoxycyclopent-2-en-1-one or a similar compound in which acetoxy is replaced by another leaving group to give, e.g. in the case of the acetoxy compound, a trans 3,4-disubstituted addition product of formula III or IV; The acetyl group is eliminated from the addition product to give an (R)- or (S)-4-alkyl or 4-alkenyl cyclopent-2-en-1-one the compound of formula is then to be hydrogenated to give a cyclopentanone of formula (I) or conjugate addition of a second organometallic nucleophile that provides a group R′ as defined above to the compound of the above formula may be carried out to give a trans 3,4-disubstituted addition product of formula (II). One of the above compounds may be converted e.g. via an intermediate (XV)-(XVIII) (in which the substituents R and R′ and the wedges have the meanings indicated above) to a gabapentin analogue of one of the formulae shown below: in which the substituents R and R′ and the wedges also have the meanings indicated above.

Method for preparing polyhydroxy benzophenone

하기한 일반식(II)와 (III)을 염화알루미늄 또는 염화아연 존재하에서 용매로는 클로로포름, 디클로로에탄, 아세토니트릴, 크실렌 등을 사용하여 구조식(IV) 화합물을 제조하고, 이를 염화알루미늄 또는 시안화나트륨과 반응시켜 구조식(I)의 화합물을 제조하는 폴리히드록시 벤조페논의 제조방법은 매우 높은 수율과 고순도의 제품을 얻을 수 있으며 또한 선택적으로 메톡시기를 히드록시기로 바꿀 수 있는 새로운 폴리히드록시 벤조페논 유도체의 제조방법이다. (식중 R 3 및 R 4 는 메틸기 또는 에틸기이며, R 1 , R 2 , n, m은 앞에서 정의한 바와 같다.)

Process for preparing 2,2,4,4-tetramethyl-1,3-cyclobutanediol

본 발명은 2,2,4,4-테트라메틸-1,3-사이클로부탄디올의 제조 방법을 개시한다. 상기 방법은 (A) 메타아크릴산(methacrylic acid, MAA)을 원료 물질로 하여 중간 물질로서 (B) 이소부티릭산(isobutyric acid, IBA), (C) 이소부티릭 언하이드라이드(isobutyric anhydride, IBAN), (D) 2,2,4,4-테트라메틸-1,3-사이클로부탄디온(2,2,4,4-tetramethyl-1,3-cyclobutanedione, CBDK)을 순차적으로 거쳐 최종 물질인 (E) 2,2,4,4-테트라메틸-1,3-사이클로부탄디올(2,2,4,4-tetramethyl-1,3-cyclobutanediol, CBDO)을 제조하는 것을 포함한다. 본 발명에 따르면 제조 단계 최적화 및 효율 극대화를 통해 경제적이고 친환경적인 2,2,4,4-테트라메틸-1,3-사이클로부탄디올의 제조 방법이 제공된다.

Manufacture of 2-alkyl-cyclopentanone

(57)【要約】本公報は電子出願前の出願データであるた め要約のデータは記録されません。

Derivative of bicyclo-octanes class, preparation method, and application of medicine

本发明涉及一种通式(I)所示的新的双环辛烷类衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂特别是作为二肽基肽酶抑制剂(DPPIV)的用途，其中通式(I)中的各取代基同说明书中的定义相同。

Cycloalkane oxidation catalysts and method to produce alcohols and ketones

본 발명은 사이클로알칸을 산화시켜 상응하는 알코올 및 케톤을 포함하는 생성물 혼합물을 형성하는 방법에 관한 것이며, 상기 방법은 금속 트리플레이트 또는 금속 트리플미데이트 촉매의 촉매 유효량의 존재 하에서 사이클로알칸을 산화제와 접촉시키는 단계를 포함한다. The present invention relates to a method for oxidizing a cycloalkane to form a product mixture comprising the corresponding alcohol and ketone, the method comprising contacting a cycloalkane with an oxidizing agent in the presence of a catalytically effective amount of a metal triflate or metal trifamide catalyst. It includes the step of making.

Branched amides of L-aspartyl-D-amino acid dipeptides

Amides of L-aspartyl-D-amino acid dipeptides of the formula ##STR1## and physiologically acceptable cationic and acid addition salts thereof wherein R a is CH 2 OH or CH 2 OCH 3 ; R is a branched member selected from the group consisting of fenchyl, diisopropylcarbinyl, d-methyl-t-butylcarbinyl, d-ethyl-t-butylcarbinyl, di-t-butyl-carbinyl, 2-methylthio-2,4-dimethylpentan-3-yl, ##STR2## said amides are potent sweeteners having advantages over the prior art, edible compositions containing them, methods for their use in edible compositions and novel amide intermediates useful in their production.

Heterocyclic inhibitors of glycogen synthase-kinase gsk-3

FIELD: organic chemistry, biochemistry. SUBSTANCE: invention relates to using compounds represented by the general formula (II): wherein R a and R b are chosen independently from hydrogen atom, alkyl, cycloalkyl, aryl (optionally substituted with a group chosen from alkyl, halogen atom and alkoxy-group), -(Z) n -aryl (optionally substituted with a group chosen from alkyl, halogen atom and alkoxy-group), -(Z) n C(O)OR 3 ; Z is chosen independently from -C(R 3 )(R 4 )-; R 3 and R 4 are chosen independently from hydrogen atom, alkyl and 6-membered cycle with nitrogen atom as a heteroatom; n has values 0, 1 or 2; X and Y are chosen independently from =O, =S and =N(R 3 ). These compounds are active component in preparing a pharmaceutical composition designated in treatment of diseases wherein glycogen synthase-kinase 3-beta (GSK-3) is involved. Also, invention relates to compounds represented by the general formula (II) wherein R a is chosen from -CH 2 Ph, -CH 2 CO 2 Et, 4-OMePh, 4-MePh and 4-BrPh; R b is chosen from Me and -CH 2 CO 2 Et; X and Y represent =O. Also, invention relates to a pharmaceutical composition possessing GSK-3-inhibitory activity and containing compound of the general formula (II) as an active component. Invention provides using heterocyclic inhibitors of glycogen synthase-kinase-3β. EFFECT: valuable biochemical and medicinal properties of inhibitors. 17 cl, 5 tbl, 5 ex ÐÎÑÑÈÉÑÊÀß ÔÅÄÅÐÀÖÈß RU (19) (11) 2 294 931 (13) C2 (51) ÌÏÊ C07D 285/08 (2006.01) C07D 417/12 (2006.01) A61K 31/433 (2006.01) A61K 31/4427 (2006.01) A61K 31/4523 (2006.01) ÔÅÄÅÐÀËÜÍÀß ÑËÓÆÁÀ ÏÎ ÈÍÒÅËËÅÊÒÓÀËÜÍÎÉ ÑÎÁÑÒÂÅÍÍÎÑÒÈ, ÏÀÒÅÍÒÀÌ È ÒÎÂÀÐÍÛÌ ÇÍÀÊÀÌ (12) ÎÏÈÑÀÍÈÅ ÈÇÎÁÐÅÒÅÍÈß Ê ÏÀÒÅÍÒÓ (21), (22) Çà âêà: 2002133222/04, 11.05.2001 (24) Äàòà íà÷àëà îòñ÷åòà ñðîêà äåéñòâè ïàòåíòà: 11.05.2001 (30) Êîíâåíöèîííûé ïðèîðèòåò: 11.05.2000 ES 200001185 12.12.2000 GB 0030284.4 (45) Îïóáëèêîâàíî: 10.03.2007 Áþë. ¹ 7 2 2 9 4 9 3 1 (85) Äàòà ïåðåâîäà çà âêè PCT íà íàöèîíàëüíóþ ôàçó: 11.12.2002 C ...

C-glucoside derivative

본 발명은 하기 화학식 I에 의해 나타내는 화합물, 그의 유도체 및 그의 용도를 포함한다: 화학식 I 상기 식들에서, R 1 , R 2 , R 3 , R 4 , R 5a , R 5b , R 5c 및 X는 상기 명세서에서와 같이 정의된다. The present invention includes compounds represented by formula (I), derivatives thereof and uses thereof: Formula I In the above formulas, R 1 , R 2 , R 3 , R 4 , R 5a , R 5b , R 5c and X are defined as described above.

Process for producing 1-hydroxyisopropylphenylketone

본 발명에 따르면, 이소프로필 페닐 케톤을 출발물질로 사용하여 무기산 촉매 존재하에 SO X Y 2 (식중, x는 1 또는 2의 정수이고, Y는 할로겐 원자를 나타낸다)로 표시되는 할로겐화 황산화물과 반응시켜 1-할로이소프로필 페닐 케톤을 제조하고, 수득된 생성물을 상전이 촉매 존재 하에 금속 수산화물의 수용액으로 처리하는 것을 특징으로 하는 1-히드록시이소프로필 페닐 케톤의 제조방법이 제조된다. According to the present invention, isopropyl phenyl ketone is used as a starting material to react with a halogenated sulfur oxide represented by SO X Y 2 (wherein x is an integer of 1 or 2 and Y represents a halogen atom) in the presence of an inorganic acid catalyst. To prepare 1-haloisopropyl phenyl ketone, and the obtained product is treated with an aqueous solution of metal hydroxide in the presence of a phase transfer catalyst to prepare 1-hydroxyisopropyl phenyl ketone. 상기 방법에 따라 1-히드록시이소프로필 페닐 케톤을 제조할 경우, 생성물의 순도 및 수율이 크게 향상되고, 종래의 방법에서보다 전체 반응시간이 단축되므로 공정 경제상 유리하다. When preparing 1-hydroxyisopropyl phenyl ketone according to the above method, the purity and yield of the product is greatly improved, and the overall reaction time is shorter than in the conventional method, which is advantageous in process economics.

Method for producing optically active ketone

Tricyclic aliphatic cpds

Cpds. have the general formula (in which Z is gps. (a) and X is gps. (e) -CH2- or (j) - CH - CH = CH-R; where R is H or 1-6C alkyl, and R' is H or a lower acyl). Pref. cpds. I (bf), I (bg), I (bh), I (ah), I (bi), and I (bj). These cpds. are chemically stable, have scent with woody, fruity or 'green' nuances, and can be used in foodstuffs, drinks, tobacco, pharmaceuticals, perfumes and cosmetics.

Derivatives of 3-cyclopropyl-1-propanone compounds and their use in perfume compositions

The present invention is directed to novel 3-cyclopropyl-1-propanone compounds of the general formula wherein R1, R2, R3, R4, R5 and R6 each independently is a hydrogen or a straight, branched or cyclic hydrocarbon moiety consisting of less then 10, preferably less then 5 carbon atoms and containing single and/or double bonds; wherein m and n each independently is an integer of 0–10; and wherein the dotted line represents a possible double bond.

Oxygenated alicyclic derivatives useful as odoriferous and flavouring ingredients

1435887 Acrylic alkenymers; alkenyne substituted cycloalkenes FIRMENICH SA 29 Jan 1975 [29 Jan 1974] 3914/75 Heading C5E [Also in Divisions C2 and A5] α-Dehydrolinalool is heated with B(OH) 3 to yield a mixture comprising 3-methylene-7- methyl - oct - 1 - yn - 7 - ene and 3,7 - dimethyl - oct - 1 - yn - 3,7 - diene. This mixture may also be obtained using #-dehydrolinalool. This mixture may be reacted with allyl chloride to give a mixture of 6-methylene-10-methylundeca - 1,10 - diene - 4 - yne and 6 - methylene - 10 - methyl - undeca - 1,9 - dien - 4 - yne which may be cyclized with formic acid to a mixture of 1-(3,3-dimethyl-cyclohex-1 and 6- en-1-yl)-pent-4-en-1-yne. This mixture may also be obtained by treating 1-(1-hydroxy-3,3- dimethyl - cyclohexyl) - pent - 4 - en - 1 - yne with B(OH) 3 . (3,3-Dimethyl-cyclohex-5-en-1- yliden)-pent-4-ene is obtained by reacting 3,3- dimethyl-cyclohex-5-en-1-one with the phosphonium bromide salt obtained from triphenylphosphine and 5-bromopent-1-ene.

Acetylcycloundecane and acetylcycloundecenes, their preparation and use in perfumery composition and as an odorant

A B S T R A C T Cyclic compounds adapted for perfumery use selected from the group consisting of acetylcycloundecane having the formula: , an acetylcycloundecene having the formula: where the double bond is in one of the three positions designated by the dashed lines, and mixtures of said three acetylcycloundecene isomers; their synthesis, their use as a perfumery agent and as an olefactant component in perfumery compositions and as an odorant for technical products. The compounds are perfumes with strong, woody-earthy lonone-ambergris odor nuances. They are used in perfume combinations in an amount of from 1% to 5% by weight.

Heterocyclic inhibitors of glycogen synthase kinase GSK-3

Compounds of general formula (I): where A, E, G, X, Y and the bond - - - take various meanings are of use in the preparation of a pharmaceutical formulation, for example in the treatment of a disease in which GSK-3 is involved, including Alzheimer's disease or the non-dependent insulin diabetes mellitus, or hyperproliferative disease such as cancer, displasias or metaplasias of tissue, psoriasis, arteriosclerosis or restenosis.

Sedative and neuroleptic cyclopropyl ketones - prepd. from a ketone carbanion and epichlorhydrin

Cyclopropane derivs. of formula (I) and their esters, salts and oximes are new (where R1R2 and R3 = alkyl; R'1,R'2 and R'3=H or alkyl; X=OH, alkoxy, CN,CHO, opt. mono- or N-or disubstd. aminoalkyl, -CH2OR or -COR'; R' = OH, NH2, N-alkyl or N,N-dialkyl amino or N-carbaminidoyl; R=H, alkyl, haloalkyl, halo hydroxyalkyl, acyl or opt. mono- or di-substd. carbamoyl). A typical cpds. is (I; R1=R2=R3=CH3; R'1=R'2=R'3;H; X=CH2OH). In an example 1 mole pinacolone was added to a soln. of sodamide in hexamethyl phosphotriamine, heated at 100 degrees C for 2 hrs. and 1 mole epichlorhydrin added to give the above cpd.

Patent FR2259091A1

NOVEL TRIFLUOROETHYLAMINES, PROCESSES FOR OBTAINING SAME AND THEIR USE AS MEDICAMENTS

L'invention a pour objet des nouvelles trifluoroéthylamines dont l'atome d'azote est substitué par un hétérocycle azoté et leur procédé d'obtention. Ces trifluoroéthylamines répondent à la formule générale :

Higher carbonyl cpds. having organoleptic properties - prepd. by reacting a substd. halide or substd. aldehyde with a carbonyl cpd. (NL 19.7.77)

Prepn. of new carbonyl cpds. comprises reacting carbonyl cpds. with organic halogen cpds. or aldehydes, to form carbonyl cpds. having a higher mol. wt. than the starting materials. New carbonyl cpds. have formula: F3=CR21-CR22O (I). Gp. C=F3 is opt. substd. 6 C cycloalkyl or cycloalkenyl. Either (i) R21 is H and R22 is a C-atom substd. by 1 or 2 of gps.: - CH...R24 ; - CH2CH:CH2 or CH2CMe:CH2 , in which R24 is alkyl, e.g. Et, alkenyl or alkylidene; or (ii) R22 is Me or H and R21 is an allyl or methallyl gp. haveing one of formulae - CH2CH:CH2 or - CH2CMe:CH2 . Alternatively Gp. C=F3 may be an acyclic hydrocarbyl, in which case (I) is 2,4,7-trimethyl-2,6-octadienal). (I) are used as aromatic essences for modifying aroma and taste of food, tobacco, beverages, and for perfumes and perfumed articles. In an example, 2,5-dimethyl-2-propenyl-hex-4-enal is prepd. by mixing 2-methyl-pent-2-enal and prenyl chloride in the presence of toluene, tricepryl methyl ammonium chloride and aq. NaOH.

oxidation method

MÉTODO DE OXIDAÇÃO A presente invenção diz respeito a um método de oxidação de um cicloalcano para formar uma mistura de produtos contendo um correspondente álcool e cetona, compreendendo o referido método contato de um cicloalcano com um hidroperóxido na presença de uma quantidade catalítica eficaz de um catalisador de titanossilicato do tipo MWW cristalino. Os hidroperóxidos podem notavelmente ser hidroperóxido de tert-butila, hidroperóxido de tert-amila, hidroperóxido de cumeno, hidroperóxido de etilbenzeno, hidroperóxido de ciclohexila, hidroperóxido de metilciclohexila, hidroperóxido de tetralina, hidroperóxido de isobutilbenzeno, e hidroperóxido de etilnaftaleno. OXIDATION METHOD The present invention relates to a method of oxidation of a cycloalkane to form a mixture of products containing a corresponding alcohol and ketone, said method comprising contacting a cycloalkane with a hydroperoxide in the presence of an effective catalytic amount of a catalyst of crystalline MWW titanosilicate. Hydroperoxides can notably be tert-butyl hydroperoxide, tert-amyl hydroperoxide, cumene hydroperoxide, ethylbenzene hydroperoxide, cyclohexyl hydroperoxide, methylcyclohexyl hydroperoxide, tetraline hydroperoxide, isobutyl benzene hydroperoxide, and ethylna hydroperoxide.

New 5, 10-seco-steroids and process for their preparation

Perfume agents prepd. by reacting isolongifolene with aldehydes - using a Prins reaction catalyst

Novel perfume cpds. are made by reacting isolongifolene (I) with a 1-6C aldehyde (II) in the presence of a catalyst for the Prins reaction (III). In particular embodiments of the process (a) (I) is reacted with formaldehyde (IV) in sufficient formic acid to dissolve the mixt., (b) (I) is reacted with (IV) in the presence oif a 1-6C carboxylic acid and a catalytic amt. of a Lewis acid or a strong mineral acid to form an ester, and this is opt. saponified with a hot aq. alkali to form a primary alcohol, (c) (I) is reacted with a formaldehyde condensate such as paraformaldehyde in an autoclave at a temp. above the normal pressure boiling point to give a primary alcohol, (d) the above primary alcohols are oxidized to the corresponding aldehydes, (e) the aldehydes of (d) are reacted with alkylmagnesium iodides with 1-5C to form secondary alcohols, (f) the secondary alcohols of (e) are oxidized to ketones. (g)(I) is reacted with 2-6C aldehydes in the presence of a Prins reaction catalyst to give a secondary alcohol, opt. followed by oxidn. a ketone, (h) any of the products (a-g) may be hydrogenated in the presence of a hydrogenation catalyst to give the corresponding satd. cpd.

Process for the preparation of new benzylamino-acanoic acids ands compounds thereof

DE DIVULGATION L'invention a pour objet l'obtention des composés de formule générale I: (I) dans laquelle R1 représente un radical alcoyle inférieur ayant de 3 à 6 atomes de carbone en chaîne linéaire ou ramifiée, R2 et R4, simultanément ou distinctement, représentent de l'hydrogène, ou un radical alcoyle inférieur linéaire ou ramifié, R3 représente de l'hydrogène, un atome d'halogène, un radical alcoxy inférieur ou un radical trifluorométhyle, A et B, identiques ou différents, représentent de l'hydrogène, un radical méthyle ou un radical éthyle, n est un nombre entier variant de 4 à 10, et Z représente hydrogène, un radical OR" dans lequel R" est un radical alcoyle inférieur, un radical alcoyle inférieur dont la chaîne alcoyle est substituée, un radical phényle ou un radical phényle substitué, ou -un radical dans lequel R et R', simultanément ou distinctement, représentent de l'hydrogène, un radical alcoyle inférieur, un radical alcényle inférieur, un radical phényle, un radical phényle alcoyle inférieur ou bien R' et R forment ensemble une chaîne alcoylène ayant de 2 à 6 atomes de carbone, éventuellement interrompue par un ou deux hétéroatomes, et des sels des composés de formule I avec un acide minéral ou organique, ainsi que des sels des composés de formule I avec une base minérale ou organique. Les composés de formule générale I manifestent des propriétés pharmacologiques intéressantes notamment dans le domaine neuro-psychiatrique.

NEW DERIVATIVES OF NORBORNAN AND NORBORNENE, THEIR USE AND SCENTED PRODUCTS CONTAINING SAME

Patent FR2281100B1

1-ethyl-33-d methyl cyclohexane derivs useful in - perfumery having flower like and woody odours

New cpds. of formula (I): (where X is H; Y is OR, R being H, acetyl, propionyl or acetoacetyl; or X and Y together form O), e.g. 1-(3:3-dimethyl-1-cyclohexyl)-ethyl propionate, 1-(3:3-dimethyl-1-cyclohexyl)-ethanol. The prepn. of these cpds. depends on the nature of Grps. X, Y and R; thus where X is H and Y is OR, R being acetyl or propionyl, the prepn. comprises reacting 2:6-dimethyl-2:7-octadiene with acetic acid or propionic acid in the presence of a Lewis acid catalyst, e.g. BF3-etherate, at 55-60 degrees C.

PROCESS FOR THE MANUFACTURE OF A TEXTILE TABLECLOTH WITH DIFFERENCES IN STIFFNESS ON THE SURFACE, PRODUCTS THUS OBTAINED AND INSTALLATION ALLOWING THE PERFORMANCE OF THE PROCESS

NOVEL IMIDAZOLE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

L'invention concerne les composés de formule gérérale (I): (CF DESSIN DANS BOPI) dans laquelle R représente un groupement alkyle inférieur (C1 -C6 ) linéaire ou ramifié, un groupement cycloalkyle (C3 -C8 ), un groupement phényle éventuellement substitué, un groupement pyridyle, un groupement naphtyl, R1 et R2 identiques ou différents représentent un atome d'hydrogène, un groupement alkyle (C1 -C6 ) linéaire ou ramifié, un groupement acyle (C1 -C6 ) linéaire ou ramifié, leurs énantiomères, diastéréoisomères et épimères ainsi que leurs sels d'addition à un acide pharmaceutiquement acceptable. Médicaments. The invention relates to the compounds of general formula (I): (CF DRAWING IN BOPI) in which R represents a lower alkyl group (C1 -C6) linear or branched, a cycloalkyl group (C3 -C8), an optionally substituted phenyl group , a pyridyl group, a naphthyl group, R1 and R2 which are identical or different represent a hydrogen atom, a linear or branched (C1 -C6) alkyl group, a linear or branched (C1 -C6) acyl group, their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid. Medicines.

PROCESS FOR THE DIACYLATION OF COMPOUNDS COMPRISING TWO AROMATIC CORES

Patent FR2314708B1

Catalyst for preparing 1,3-cyclopentanediol, method for preparing 1,3-cyclopentanediol using the same, and 1,3-cyclopentanediol prepared by using the same

4-하이드록시-2-사이클로펜테논(4-hydroxy-2-cyclopentenone)을 수첨 반응시켜 1,3-사이클로펜탄디올(1,3-cyclopentanediol)을 제조하기 위한 촉매로서, α-Al 2 O 3 를 포함하는 담체, 및 상기 담체에 담지된 활성 금속을 포함하는, 1,3-사이클로펜탄디올 제조용 촉매를 제공한다.

Patent FR1579952A

Disubstituted pyrimidines

Pyrimidines of the formula: ##STR1## wherein Y is nitrogen and Z is ═CH--, or Z is nitrogen and Y is ═CH--; R 1 is alkyl and R 2 is cyano, alkyl, p-alkylphenyl or trans-4-alkylcyclohexyl; where each alkyl denotes either a straight chain alkyl group of 1 to 12 carbon atoms or a branched chain alkyl group of the formula C 2 H 5 --CH(CH 3 )--(CH 2 ) n , n is 1, 2 or 3; with the proviso that the compound contains at most only one of said branched chain alkyl group and with the further proviso that the sum of the carbon atoms in all of the alkyl groups within the compound is at most 14 are described. Liquid crystalline mixtures comprising Compound I as well as their use in electro-optical devices also are disclosed.

Improvements to processes for the production of dicarbonyl compounds

Sphingosine kinase inhibitors

Compuesto de fórmula**Fórmula** o una sal farmaceuticamente aceptable, hidrato o solvato del mismo, en la que: Y es -N(R4)-; R1 es fenilo, sustituido con 1 ó 2 halogenos, R2 es arilo, -alquilarilo, heterocicloalquilo, -alquil-heterocicloalquilo, heteroarilo o -alquil-heteroarilo opcionalmente sustituido; R3 es H, alquilo u oxo; en la que la parte de alquilo y anillo de cada uno de los grupos R2 y R3 anteriores esta opcionalmente sustituida con hasta 5 grupos que son independientemente alquilo (C1-C6), halógeno, haloalquilo, -0C(0)(alquilo C1-C6), -C(0)0(alquilo C1-C6), -CONR'R", -0C(0)NR' R", -NR'C(0)R", -CF3, -0CF3, -OH, alcoxilo hidroxialquilo, -CN, -CO2H, -SH, -S-alquilo, -SOR'R", -SO2R', -NO2 o NR'R", en la que R' y R" son independientemente H o alquilo (C1-C6), y en la que cada parte de alquilo de un sustituyente esta opcionalmente sustituida adicionalmente con 1, 2 1:5 3 grupos seleccionados independientemente de halógeno, CN, OH y NH2; y R4 es H o alquilo (C1-C6). Compound of formula ** Formula ** or a pharmaceutically acceptable salt, hydrate or solvate thereof, in which: Y is -N (R4) -; R1 is phenyl, substituted with 1 or 2 halogens, R2 is aryl, -alkylaryl, heterocycloalkyl, -alkyl-heterocycloalkyl, heteroaryl or -alkyl-heteroaryl optionally substituted; R3 is H, alkyl or oxo; wherein the alkyl and ring portion of each of the above R2 and R3 groups is optionally substituted with up to 5 groups that are independently (C1-C6) alkyl, halogen, haloalkyl, -0C (0) (C1-C6 alkyl ), -C (0) 0 (C1-C6 alkyl), -CONR'R ", -0C (0) NR 'R", -NR'C (0) R ", -CF3, -0CF3, -OH, hydroxyalkyl alkoxy, -CN, -CO2H, -SH, -S-alkyl, -SOR'R ", -SO2R ', -NO2 or NR'R", in which R' and R "are independently H or (C1 alkyl) -C6), and in which each alkyl part of a substituent is optionally further substituted with 1, 2 1: 5 3 groups independently selected from halogen, CN, OH and NH2; and R4 ...

Process for producing large cyclic ketone and intermediate therefor

A process for producing muscone by methyl addition to the 1,4-conjugation of 2-cyclopentadecenone. By the process, muscone is produced in high yield not under reaction conditions including an extremely low temperature and a low concentration but under practical conditions. The process comprises subjecting 2-cyclopentadecenone to a 1,4-conjugation addition reaction with an organometallic methylation reagent in the presence of a copper catalyst or nickel catalyst and an enol anion-trapping agent to obtain a 3-methyl-1-cyclopentadecene derivative represented by the general formula (II): (II) and then solvolyzing the enol moiety of this 3-methyl-1-cyclopentadecene derivative to obtain muscone.

NEW CARBAMATES, THEIR PRODUCTION AND THE PHARMACEUTICAL PREPARATIONS CONTAINING THEM

METHOD FOR THE PREPARATION OF NEW IMIDAZOLE DERIVATIVES

New aldehydes with norbornane structures, their preparation and use in perfume making

3-(2,3-Dimethyl-bicyclo[2.2.1]hept-2-yl)-propionaldehyde (I) is new. An independent claim is included for the preparations of (I).

Two process for acylating that contain the compound of two aromatic rings

下列通式(I)的化合物的二酰化方法，通式中 X代表O、S、 或-CH 2 -，R 1 、R 2 、R 3 、R 4 可相同或 不同，为H或含1至4个碳原子的烷基，该方法是将 式(I)化合物，在-40℃至0℃的温度下，与HF、BF 3 和每摩尔式(I)化合物至少2摩尔的酰化剂接触，进 行反应。

New derivatives of norbornane and norbornene, used as fragrances in perfumed products such as soap, perfume, toilet water, shampoo, detergents and deodorants

Derivatives of 2,3-dimethyl-norbornane and -norbornene with various hydroxylated or acylated and optionally unsaturated, groups at position 3 are new. Compounds of formula (I) are new. R1 = (a) -CH(CH3)OH, -CH(CH3)OCOR, -CH(CH3)XCH2CH(OH)R' or -CH(CH3)OCHR'CH2OH (if the dotted line bond is present) or (b) -CH(CH3)OH, -CH(CH3)OCOR, -COCH3, a group of formula (II), -CH(CH3)XCH2CH(OH)R', -CH2CH2XCH2CH(OH)R', -CH=CH2, -CH=CHCOR', -CH2CH2CHR'OH, -CH2CH2CHR'OCOR, -CH=CH-CH(OH)R' or -CH=CH-CHR'OCOR (if the dotted line bond is absent); R = H, methyl, ethyl, n- or iso-propyl, butyl, isobutyl, CH3(CH2)4-, (CH3)2CHCH2-, CH2=CH- or (CH3)2C=CH-; R' = H, methyl or ethyl; X = O, N or S Independent claims are also included for (1) a method for the preparation of (I) from a starting material or intermediate of formula (III); (2) perfumed products containing (I), especially perfumes, toilet water, cosmetics such as soap, shower or bath gel, shampoo and other hair hygiene products, other care products (for washing and softening) and deodorants for personal use or in the ambient air.

Certain 2-(2-substituted benzoyl)-1,3- cyclohexanediones

CERTAIN 2-2(SUBSTITUTED BENZOYL)-1,3-CYCLOHEXANADIONES Abstract of the Invention Compounds having the structural formula wherein R is C1-C6 alkyl; R1 is hydrogen, C1-C6 alkyl, or wherein Ra is C1-C4 alkyl or R and R1 together are alkylene having 3 to 6 carbon atoms; R2 is chlorine, bromine, iodine or C1-C4 aliphatic aloxy; R3 and R4 independently are hydrogen or an aliphatic group; R5 is hydrogen or C1-C6 alkyl; and R6 is hydrogen or C1-C6 alkyl; and their salts. These compounds are useful as herbicides.

Cycloalkane oxidation catalyst and method for producing alcohol and ketone

Process for the preparation of 1-fluorocyclopropyl-methyl-ketone

1-Fluorocyclopropyl methyl ketone, which is known and has the formula <IMAGE> can be prepared by a novel process by reacting, a) in a first step, 2-acetyl-2-chloro-4-butanolide, of the formula <IMAGE> with an addition product of triethylamine with hydrogen fluoride which has the formula (C2H5)3N . n HF (III> in which n represents the numbers 1, 2 or 3, in the presence of a diluent at temperatures between 20 DEG C and 120 DEG C, and b) in a second step, reacting the resulting 2-acetyl-2-fluoro-4-butanolide, which has the formula <IMAGE> with a nucleophilic agent in the presence of a diluent at temperatures between 50 DEG C and 200 DEG C.