СПОСОБ КАРБОНИЛИРОВАНИЯ ПРОСТЫХ АЛКИЛОВЫХ ЭФИРОВ

Изобретение относится к способу получения низшего сложного алкилового эфира низшей алифатической карбоновой кислоты, имеющего формулу R1-COO-R2 заключающемуся во взаимодействии предварительно высушенного низшего простого алкилового эфира, имеющего формулу R1-O-R2, в которой R1 и R2 независимо представляют собой C1-С6 алкильные группы, при условии, что суммарное число атомов углерода в группах R1 и R2 составляет от 2 до 12, или R1 и R2 вместе образуют С2-С6 алкиленовую группу, с сырьем, содержащим монооксид углерода, в присутствии катализатора, содержащего морденит и/или ферриерит в безводных условиях. Также изобретение относится к способу получения карбоновых кислот гидролизом получаемых обозначенным выше способом сложных эфиров. Применение настоящего способа позволяет повысить выход и селективность по целевому продукту. 2 н. и 27 з.п. ф-лы, 3 табл., 6 ил.

СПОСОБ КАРБОНИЛИРОВАНИЯ ПРОСТЫХ АЛКИЛОВЫХ ЭФИРОВ

... 1. Способ получения продукта, содержащего низший сложный алкиловый эфир низшей алифатической карбоновой кислоты, имеющий формулу ! R1-COO-R2, ! заключающийся во взаимодействии низшего простого алкилового эфира, имеющего формулу ! R1-O-R2, ! в которой R1 и R2 независимо представляют собой C1-С6алкильные группы при условии, что суммарное число атомов углерода в группах R1 и R2 составляет от 2 до 12, или R1 и R2 вместе образуют С2-С6алкиленовую группу, с сырьем, содержащим монооксид углерода, в присутствии катализатора, содержащего морденит и/или ферриерит, в практически безводных условиях. ! 2. Способ по п.1, в котором сложный эфир представляет собой метилацетат, и простой эфир означает диметиловый эфир. ! 3. Способ по п.1, в котором катализатор является Н-морденитом. ! 4. Способ по п.1, в котором температура составляет приблизительно от 100 до 250°С. ! 5. Способ по п.1, в котором температура составляет приблизительно от 150 до 180°С. ! 6. Способ по п.1, в котором катализатор содержится в ...

СПОСОБ ОЧИСТКИ СМЕСЕЙ МЕТИЛАЦЕТАТА

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2016 146 554 A (51) МПК C07C 67/37 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2016146554, 12.06.2015 (71) Заявитель(и): БП КЕМИКЭЛЗ ЛИМИТЕД (GB) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): БРИСТОУ Тимоти Криспин (GB) 20.06.2014 EP 14173354.3 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 28.11.2016 R U (43) Дата публикации заявки: 30.05.2018 Бюл. № 16 (86) Заявка PCT: (87) Публикация заявки PCT: WO 2015/193182 (23.12.2015) R U (54) СПОСОБ ОЧИСТКИ СМЕСЕЙ МЕТИЛАЦЕТАТА (57) Формула изобретения 1. Способ удаления ацетальдегида из смеси метилацетата, диметилового эфира и ацетальдегида, включающий (i) загрузку смеси метилацетата, ацетальдегида и диметилового эфира в дистилляционную колонну; (ii) дистилляцию смеси с получением отводимого с верха колонны потока, обедненного ацетальдегидом по сравнению с загруженной смесью, основного потока, обедненного ацетальдегидом по сравнению с загруженной смесью, и бокового потока, обогащенного ацетальдегидом по сравнению с загруженной смесью; (iii) отбор из колонны бокового потока, обогащенного ацетальдегидом, в положении выше положения загрузки смеси, загружаемой в колонну; и в котором смесь, загружаемую в дистилляционную колонну, получают с помощью одного или большего количества способов карбонилирования диметилового эфира монооксидом углерода в присутствии цеолитного катализатора карбонилирования. 2. Способ по п. 1, который включает дополнительную стадию (iv), на которой по меньшей мере часть бокового потока, отбираемого из продуктов дистилляции на стадии (iii), содержащего ацетальдегид, диметиловый эфир и один или большее количество следующих: метилацетат, метанол и вода, подают в качестве сырья во вторую дистилляционную колонну и дистиллируют в ней для отбора из колонны бокового потока, обогащенного ацетальдегидом по сравнению с загруженной смесью, головного Стр.: 1 A 2 0 1 6 1 4 6 5 5 4 A Адрес ...

Formyl propyl acetate prepn from allyl acetate - by hydroformulation using dicobalt octacarbonyl catalyst in paraffin as solv

Prepn. of formyl propyl acetates of formula OHC -(n-C3H6)-O-CO-CH3 (I) (where formyl gp. can be in position 1, 2 or 3 of n-C H6 grouping) by hydroformylation of allyl acetate with CO and H2 in the presence of an organic solvent and CO2(CO)8 as catalyst takes place by (a) using paraffins or paraffin mixts. which are liquid at 40-120 degrees C as organic solvents, and (b) maintaining in paraffin phase a concn. of 0.05-1.5 wt. % CO2(CO)8, w.r.t. paraffin. (I) can be obtd. in >95% purity and 85-95% yields; reaction times are short and reaction mixt. is easily processed; (I) are insoluble in paraffins whereas CO2(CO)8 can be enriched therein to an extent of 70-80%. Catalyst-contg. paraffin phase can be returned to hydroformylation after separating (I). Isomer mixt. (I) can be hydrogenated to diols, useful as components in polyester and polyurethane chemistry.

Riechstoffkompositionen

Production of tertiary butyl acetate

Tertiary butyl acetate is produced by contacting isobutene with a mixture of from 0.5% to 30% by weight of sulphuric acid in acetic acid, neutralizing the sulphuric acid with aqueous alkali, removing hydrocarbon from the product by distillation and distilling the resulting mixture to recover tertiary butyl acetate and unreacted acetic acid. The isobutene may be used in liquid or vapour form, and may contain other hydrocarbons. Suitable procedures for recovery of the tertiary butyl acetate are described. Some tertiary butanol may be obtained during the separation.

Process

Aliphatic Alcohol, Ester and Aldehyde Odorants

... 1,167,776. Perfumes. L. GIVAUDAN & GIE S.A. 3 Aug., 1967 [3 Aug., 1966], No. 35795/67. Heading A5B. [Also in Division C2] Perfume compositions contain besides conventional perfume ingredients, compounds of formula: wherein R1 is C 1-4 alkyl, R2 is C 1-5 alkyl or Ph [or R1-R2 is -(CH 2 ) 4-5 -], R3 is Me or Et, and R4 is CHO (possibly acetalised), CH 2 OH or its carboxylic-acid-derived acylate, as well as their #5- and #6- dehydro derivatives, and their 6-hydroxy derivatives.

Process for the manufacture of alkyl esters

Alkyl esters of aliphatic carboxylic acids are prepared by absorbing an olefine in concentrated sulphuric acid under elevated pressure, reacting with mono-chloroacetic acid, separating the alkyl monochloroacetate by distillation, reacting the separated product with an aliphatic carboxylic acid (other than monochloroacetic acid) in the presence of concentrated sulphuric acid, and separating the resultant alkyl ester of the aliphatic carboxylic acid by distillation. The sulphuric acid from the first distillation stage may be recycled, and the excess carboxylic acid recovered in the final separation may also be recycled. Straight or branched chain olefines, e.g. ethylene, propylene and butene-1, may be used. An example describes the preparation of ethyl acetate from ethylene and acetic acid and detailed apparatus is also described.

Aglycones and their process of obtaining.

PROCEDURE FOR the PRODUCTION of the NEW ONE 3-ACETOXY-2-METHYLPROPIONALDEHYDS

MANUFACTURING PROCESS OF METHYL ACETATE FROM METHYL FORMATE.

Procedure for the production of β-Acetoxypivalinaldehyd

Procedure for the production of insatiated esters of carbonic acids

PRODUCTION OF ACETIC ACID AND/OR METHYL ACETATE IN PRESENCE OF IRIDIUM AND PLATINUM

Phenoxy acids for the treatment of neuromuscular disorders

The present invention relates to compounds suitable for treating, ameliorating and/or preventing neuromuscular disorders, including the reversal of drug-induced neuromuscular blockade. The compounds as defined herein preferably inhibit the ClC- 1 ion channel.

ESTERS FROM ACYLHALIDES FROM CARBON MONOXIDE AND HALO ACIDS

Method for preparing acetic acid and/or methyl acetate in the presence of iridium and platinum

Methyl acetate preparation method

The present invention provides a methyl acetate preparation method. The method comprises: performing carbonylation of dimethyl ether and a feed gas comprising carbonic oxide and hydrogen on a catalysator of an acid EMT-structure zeolite molecular sieve, to obtain methyl acetate. The present invention provides a new method for producing methyl acetate. The method is performed with the existence of an acid EMT zeolite molecular sieve serving as a catalysator, reaction activity is high, stability is obviously improved, and an industrial production requirement can be met.

PROCESS FOR PRODUCING .alpha.-ACETOXYPROPIONALDEHYDE

A METHOD FOR PRODUCING METHYL ACETATE

The present invention provides a methyl acetate preparation method. The method comprises: performing carbonylation of dimethyl ether and a feed gas comprising carbonic oxide and hydrogen on a catalysator of an acid EMT-structure zeolite molecular sieve, to obtain methyl acetate. The present invention provides a new method for producing methyl acetate. The method is performed with the existence of an acid EMT zeolite molecular sieve serving as a catalysator, reaction activity is high, stability is obviously improved, and an industrial production requirement can be met.

IMPROVED CATALYTIC PERFORMANCE IN PROCESSES FOR PREPARING ACETIC ACID

In processes for the hydrolysis of a methyl acetate with at least one of water and methanol in the presence of at least one Brønsted acid catalyst to produce acetic acid the performance of the catalyst is improved by using a methyl acetate feed in which the total amount of acetaldehyde and 1,1 dimethoxyethane impurities is maintained at 100 ppm wt or less calculated as mass equivalents of acetaldehyde.

PROCESS FOR THE ALKOXYCARBONYLATION OF ALCOHOLS

The invention relates to a process comprising the following process steps: a) introducing a first alcohol, the first alcohol having 2 to 30 carbon atoms; b) adding a phosphine ligand and a compound which comprises Pd, or adding a complex comprising Pd and a phosphine ligand; c) adding a second alcohol; d) supplying CO; e) heating the reaction mixture, the first alcohol reacting with CO and the second alcohol to form an ester; where the phosphine ligand is a compound of formula (I) where m and n are each independently 0 or 1; R1, R2, R3, R4 are each independently selected from -(C1-C12)-alkyl, -(C3-C12)- cycloalkyl, -(C3- C12)-heterocycloalkyl, -(C6-C20)-aryl, -(C3-C20)-heteroaryl; at least one of the R1, R2, R3, R4 radicals is a -(C3-C20)-heteroaryl radical; and R1, R2, R3, R4, if they are -(C1-C12)-alkyl, -(C3-C12)-cycloalkyl, -(C3-C12)- heterocycloalkyl, -(C6- C20)-aryl or -(C3-C20)-heteroaryl, may each independently be substituted by one or more substituents selected from -(C1-C12)-alkyl ...

Acetylenic Biaromatic Compounds Containing an Adamantyl Group; Pharmaceutical and Cosmetic Compositions Containing Them and Uses Thereof

Procédé de production d'esters aliphatiques inférieurs

Utilisation de dérivés oxygénés de la décaline comme agents odoriférants

VERFAHREN ZUR HERSTELLUNG VON (BETA)-ACETOXYPIVALINALDEHYD.

Riechstoffkompositionen

Verfahren zur Herstellung ungesättigter Ester von Carbonsäuren

Verfahren zur Herstellung von Carbonsäureallylestern

Utilisation de cétones alicycliques comme agents odoriférants

Verfahren zur Herstellung von B-Acetoxypivalinsäureanhydrid

DERIVATIVES 8 EXO HYDROXYMETHYL-ENDO TRICYCLO (5.2.1. OF O (2.6)) - DECANE DERIVATIVES.

3-Acetoxy-cyclo:butanone prodn.

In the prepn. of the new cpd. 3-acetoxy-cyclobutanone (I) 3-acetoxycyclobutenone (II) or a (II)-contg. mixt. is hydrogenated using a hydrogenation catalyst at -10 to +30 degrees C and 0-20 atm. (gauge), and (I) is isolated fom the reaction mixt. by distn.(I) is an intermediate for insecticides, pesticides, nematocides or fungicides. (II) can be prepd. by cycloaddition of ketene to ethoxyacetylene and hydrolysis and acetylation of the product.In an example the hydrogenation of crude (II) over 5% Pd-C at 0 degree C/atmospheric press. gives, after distn., (I) contg. traces of beta-butyrolactone (due to diketene in the ketene used for preparing the starting material).

PERFUMING INGREDIENTS FROM ALCOHOLS AND ALIPHATIC ESTERS.

PROCEDURE FOR THE PRODUCTION OF CARBONIC ACID ESTERS.

PROCEDURE FOR THE PRODUCTION OF CARBONIC ACID ESTERS.

Processo per la preparazione di 9ß,10a-progesterone (retroprogesterone).

La presente invenzione si riferisce ad un nuovo processo per la sintesi di (9β,10α)-pregn-4-ene-3,20-dione, comunemente noto come retroprogesterone, di formula (1) sotto riportata: ...

PRODUCTION OF METHYL ACETATE

Изобретение обеспечивает способ получения метилацетата, и способ предусматривает стадию, на которой диметиловый эфир и сырьевой газ, содержащий монооксид углерода и водород, проходят через реактор, загруженный катализатором, для проведения реакции карбонилирования; причем катализатор содержит кислотное цеолитное молекулярное сито типа EMT. Настоящее изобретение обеспечило новый способ получения метилацетата. В способе настоящего изобретения карбонилирование проводят в присутствии катализатора, содержащего кислотное цеолитное молекулярное сито типа EMT, и активность реакции высока, а стабильность была значительно повышена, удовлетворяя требованию промышленного производства. The invention provides a method for producing methyl acetate, and the method includes a step in which dimethyl ether and feed gas containing carbon monoxide and hydrogen pass through a reactor loaded with a catalyst to conduct a carbonylation reaction; moreover, the catalyst contains an acidic zeolitic molecular sieve type EMT. The present invention has provided a new method for producing methyl acetate. In the process of the present invention, the carbonylation is carried out in the presence of a catalyst containing an EMT-type acidic zeolitic molecular sieve, and the reaction activity is high and the stability has been significantly increased, meeting the requirements of industrial production.

METHOD OF PRODUCING ALKYL ESTER FATTY ACID

CARBONYLATION PROCESS

PROCESS FOR THE CO-PRODUCTION OF ACETIC ACID AND DIMETHYL ETHER

Perfume systems

A method for the production of acetic acid methyl ester

PROCEDE POUR PRODUIRE DES ESTERS CARBOXYLIQUES A PARTIR DE DERIVES ANIONIQUES D'ACYLIUM FORMES PAR CARBONYLATION

L'INVENTION CONCERNE UN PROCEDE POUR PRODUIRE DES ESTERS CARBOXYLIQUES A PARTIR DE DERIVES ANIONIQUES D'ACYLIUM FORMES PAR CARBONYLATION; ON FORME DES ESTERS CARBOXYLIQUES, PAR EXEMPLE DE L'ISOBUTYRATE DE METHYLE, PAR ESTERIFICATION 40 D'UN DERIVE ANIONIQUE D'ACYLIUM 20, PAR EXEMPLE LE FLUORURE D'ISOBUTYRYLE, AVEC UNE QUANTITE D'ALCOOL 42, PAR EXEMPLE LE METHANOL, INFERIEURE A LA QUANTITE NECESSAIRE POUR REAGIR AVEC LA TOTALITE DU DERIVE ANIONIQUE D'ACYLIUM, DANS DES CONDITIONS TELLES QUE L'ACIDE ANHYDRE, PAR EXEMPLE L'ACIDE FLUORHYDRIQUE, SOIT REGENERE.

Manufactoring process of a liquid having an energetic capacity of dissolution on many substances

A method for preparing the isopropyl acetate

Preparados de depósito

Process for the co-production of acetic acid and dimethyl ether

A process for the co-production of acetic acid and dimethyl ether with reduced formic acid content by distilling a mixture comprising dimethyl ether, methanol and methyl formate; separating methyl formate from the mixture to recover dimethyl ether and methanol; and catalytically reacting the methanol and methyl acetate to produce a reaction product of acetic acid and dimethyl ether.

Process for the alkoxycarbonylation of ethers

The invention relates to a process comprising the following process steps: (a) introducing an ether having 3 to 30 carbon atoms; (b) adding a phosphine ligand and a compound which comprises Pd, or adding a complex comprising Pd and a phosphine ligand; (c) adding an alcohol; (d) supplying CO; (e) heating the reaction mixture, the ether being reacted for form an ester; where the phosphine ligand is a compound of formula (I) where m and n are each independently 0 or 1; R1, R2, R3, R4 are each independently selected from -(C1-C12)-alkyl, -(C3-C12)-cycloalkyl, -(C3-C12)-heterocycloalkyl, -(C6-C20)-aryl, -(C3-C20)-heteroaryl; at least one of the R1, R2, R3, R4 radicals is a -(C3-C20)-heteroaryl radical; and R1, R2, R3, R4, if they are -(C1-C12)-alkyl, -(C3-C12)-cycloalkyl, -(C3-C12)-heterocycloalkyl, -(C6-C20)-aryl or -(C3-C20)-heteroaryl, may each independently be substituted by one or more substituents selected from -(C1-C12)-alkyl, -(C3-C12)-cycloalkyl, -(C3-C12)-heterocycloalkyl, -O-(C1-C12 ...

PROCESS FOR THE CO-PRODUCTION OF ACETIC ACID AND DIMETHYL ETHER

Ether, polymer, resist composition and patterning process

An ether compound of formula (1) is provided in which R1 is H or C1-6 linear, branched or cyclic alkyl, R2 is C1-6 linear, branched or cyclic alkyl, R3 is H, C1-15 acyl or C1-15 alkoxycarbonyl which may be substituted with halogen atoms, k is 0 or 1, m is from 0 to 3, and n is from 3 to 6. The ether compound is polymerized to form a polymer having improved reactivity, robustness and substrate adhesion. A resist composition comprising the polymer as a base resin is sensitive to high-energy radiation, has excellent sensitivity, resolution, and etching resistance, and lends itself to micropatterning with electron beams or deep-UV. The resist material has low absorption particularly at an exposed wavelength of an ArF excimer laser or a KrF excimer laser and therefore can easily form a fine pattern perpendicular to a substrate.

ERYTHROMYCIN ETHYLSUCCINATE CRYSTALLINE HYDRATE, PREPARATION AND USES THEREOF

Disclosed is an anti-infective drug―macrolide compound, preparation and uses thereof. Macrolide compound, namely erythromycin ethylsuccinate crystalline hydrate, which has less moisture absorption and good storage stability, can be used in the preparation of drugs for the treatment and prevention of human or animal infectious diseases caused by Gram-positive or negative bacteria.

Process for the carbonylation of dimethyl ether

Process for producing methyl acetate by carbonylating a dimethyl ether feed with carbon monoxide under substantially anhydrous conditions in the presence of a mordenite catalyst which has been ion-exchanged or otherwise loaded with at least one of silver and copper. The mordenite is also ion-exchanged or otherwise loaded with platinum in an amount in the range 0.05 to 10 mol % relative to aluminum.

CYCLOHEXANE DERIVATIVES

СПОСОБ СОВМЕСТНОГО ПОЛУЧЕНИЯ УКСУСНОЙ КИСЛОТЫ И ДИМЕТИЛОВОГО ЭФИРА

Изобретение относится к способу совместного получения уксусной кислоты и диметилового эфира путем дегидратации-гидролиза смеси метанола и метилацетата, проводимому при температуре, равной от 100 до 350°C, и атмосферном или более высоком давлении в присутствии по меньшей мере одного твердого кислотного катализатора и воды с получением продукта реакции, содержащего диметиловый эфир и уксусную кислоту, где в этом способе количество воды для дегидратации-гидролиза регулируют путем: дегидратации метанольного сырья, содержащего метанол и воду, с получением неочищенного продукта дегидратации, содержащего диметиловый эфир, непрореагировавший метанол и воду; извлечения из неочищенного продукта дегидратации i) потока диметилового эфира, содержащего диметиловый эфир, воду и метанол, и ii) потока воды; выделения диметилового эфира из потока диметилового эфира с получением потока метанола, содержащего метанол и воду; и введения в реакцию дегидратации-гидролиза потока метанола или его части, метилацетата ...

УЛУЧШЕННЫЕ КАТАЛИТИЧЕСКИЕ ХАРАКТЕРИСТИКИ В СПОСОБАХ ПОЛУЧЕНИЯ УКСУСНОЙ КИСЛОТЫ

Изобретение относится к усовершенствованному способу превращения метилацетатного сырья и по меньшей мере одного из следующих: вода и метанол в присутствии по меньшей мере одного катализатора - кислоты Бренстеда - цеолита или гетерополикислоты с получением уксусной кислоты, где в этом способе рабочие характеристики катализатора или катализаторов улучшены, в котором полное количество примесей ацетальдегида и 1,1-диметоксиэтана в метилацетатном сырье поддерживается равным 100 мас. част./млн или менее при пересчете на масс-эквиваленты ацетальдегида и в котором метилацетатное сырье получают из способов карбонилирования диметилового эфира содержащим монооксид углерода газом в присутствии цеолитного катализатора карбонилирования. 18 з.п. ф-лы, 5 табл., 4 пр.

СПОСОБ ПОЛУЧЕНИЯ МЕТИЛАЦЕТАТА/УКСУСНОЙ КИСЛОТЫ

... 1. Способ получения по меньшей мере одного из перечисленных веществ: метилацетата и уксусной кислоты, который включает контактирование в реакторе газа, содержащего монооксид углерода, и способного к карбонилированию реагента, выбранного из по меньшей мере одного из следующих веществ: метанол и его реакционно-способные производные, с катализатором, который включает морденит, содержащий медь и серебро, причем медь и серебро, введены методом ионного обмена всех или части катионообменных центров морденита на ионы меди и серебра, с получением по меньшей мере одного из веществ: метилацетат и уксусная кислота, с последующей регенерацией катализатора.2. Способ по п.1, в котором для введения меди и серебра применяют морденит, который находится в аммониевой форме или в протонированной форме.3. Способ по п.1, в котором введение меди и серебра в морденит проводят методом последовательного ионного обмена.4. Способ по любому из пп.1-3, в котором в морденит вводят медь в количестве в интервале от 5 до ...

СПОСОБ КАРБОНИЛИРОВАНИЯ ДЛЯ ПОЛУЧЕНИЯ МЕТИЛАЦЕТАТА

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2018 140 198 A (51) МПК C07C 67/37 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2018140198, 12.04.2017 (71) Заявитель(и): БП КЕМИКЭЛЗ ЛИМИТЕД (GB) Приоритет(ы): (30) Конвенционный приоритет: 19.04.2016 GB 1606812.4 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 19.11.2018 R U (43) Дата публикации заявки: 19.05.2020 Бюл. № 14 (72) Автор(ы): КЛАРК Томас Эдвард (GB), ХЕЙЗЕЛ Николас Джон (GB), САНЛИ Джон Гленн (GB) (86) Заявка PCT: (87) Публикация заявки PCT: WO 2017/182359 (26.10.2017) R U (54) СПОСОБ КАРБОНИЛИРОВАНИЯ ДЛЯ ПОЛУЧЕНИЯ МЕТИЛАЦЕТАТА (57) Формула изобретения 1. Способ карбонилирования диметилового эфира монооксидом углерода в присутствии катализатора, содержащего цеолит, для получения продукта реакции метилацетата, где способ проводят при температуре, равной от 250 до 350°С, сырье для проведения способа содержит диметиловый эфир, монооксид углерода, водород и метилацетат и отношение количества молей водорода к количеству молей монооксида углерода в сырье равно не менее 1, и где сырье дополнительно содержит одно или большее количество соединений, содержащих функциональную гидроксигруппу. 2. Способ по п. 1, в котором цеолитом является полученный с использованием реагента для матричной сборки цеолит. 3. Способ по п. 1 или 2, в котором сырье содержит гидроксисоединение (гидроксисоединения) в полном количестве, составляющем вплоть до 1 мол. % в пересчете на полное количество газов, загружаемых для проведения способа. 4. Способ по п. 3, в котором сырье содержит гидроксисоединение (гидроксисоединения) в полном количестве, составляющем от 0,01 до 0,5 мол. % в пересчете на полное количество газов, загружаемых для проведения способа. 5. Способ по любому из предыдущих пунктов, в котором сырье содержит метилацетат и гидроксисоединение (гидроксисоединения) при отношении количества молей метилацетата к количеству молей гидроксисоединения ( ...

СПОСОБ КАРБОНИЛИРОВАНИЯ ДИМЕТИЛОВОГО ЭФИРА

ESTER DES 1.7.7-TRIMETHYL-BICYCLO- ECKIGE KLAMMER AUF 4.4.0 ECKIGE KLAMMER ZU -DECANOLS-(3)

Verfahren zur Geruchsverbesserung von Loesungsmitteln

3-ACETOXY-2-METHYLPROPIONALDEHYD UND VERFAHREN ZU SEINER HERSTELLUNG.

CYCLOHEXANE DERIVATIVES

CHEMICAL PROCESS

Multifunctional alcohols obtained from cardonal, multifunctional acrylic crosslinker and pendant phosphorous flame retardant derivatives thereof

Multifunctional alcohols, polyols derived from cardanol containing at least 3 hydroxyl groups are disclosed. Such alcohols allow for synthesis of multifunctional crosslinkers such as acrylates, epoxies, and vinyl ethers and flame retardants such as phosphates. The multifunctional alcohols or polyols can be used in polyurethanes and polycarbonates. The multifunctional crosslinkers can be used in optical coating and waveguide compositions to increase curing speed and crosslink density. The multifunctional phosphates can be used in flame resistant plastics as the highly pendant phosphorus containing phosphate non-halogen flame retardant additives.

Improvements in the production of esters

... 301,523. Imperial Chemical Industries, Ltd., and Horsley, G. F. Aug. 3, 1927. Esters. - In a continuous process for producing esters by reaction of an alcohol and an acid, in which the ester is removed in the form of vapour of an azeotropic mixture of ester, alcohol, and water, water and in some cases ester is added to the reacting mixture to facilitate the formation of the azeotropic mixture. A catalyst such as phosphoric acid may be added to the reacting mixture. On condensation, the azeotropic mixture forms into two layers, which are preferably separated at a high temperature. A part of the aqueous layer may, before or after distillation to separate alcohol and ester, be added to the reacting mixture. The ester layer is boiled to separate first a ternary mixture of ester, alcohol and water, and then a binary mixture of ester and alcohol. As applied to a continuous process for forming isobutyl acetate, isobutyl alcohol, acetic acid and water are supplied continuously from vessels 1, 2 ...

CARBOXYLIC ACID ESTERS

VERFAHREN ZUR HERSTELLUNG EINES NIEDERALKYLESTERS DER ISOBUTTERSAEURE AUS ISOBUTYRYLFLUORID

MANUFACTURING PROCESS OF AETHYLACETAT THROUGH HOMOLOGISIERUNG FROM METHYL ACETATE.

PRODUCTION OF CARBOXYLIC ESTERS FROM ACYLIUM ANIONS FORMED BY CARBONYLATION

Carboxylic esters, e.g. methyl isobutyrate, are formed by esterifying an acylium anion product, e.g., isobutyryl fluoride, with less than the total amount of alcohol, e.g., methanol, required to react with the acylium anion product under conditions whereby the anhydrous acid e.g., hydrogen fluoride, is regenerated.

A METHOD FOR PRODUCING LIGHT FATTY ACID ALKYL ESTER

The present invention provides a lower fatty carboxylic acid alkyl ester production method. The method comprises: performing carbonylation of alkyl ether (R1-O-R2) and a feed gas comprising carbonic oxide (CO) on a catalysator of an acid EMT zeolite molecular sieve, to obtain fatty acid alkyl ester (R1-COO-R2), R1 and R2 independently indicating C1-C4 alkyl groups respectively. The present invention provides a new method for producing lower fatty acid alkyl ester. The method is performed with the existence of an acid EMT zeolite molecular sieve serving as a catalysator, reaction activity is high, stability is obviously improved, and an industrial production requirement can be met.

PROCESS FOR THE CO-PRODUCTION OF ACETIC ACID AND DIMETHYL ETHER

A process for the co-production of acetic acid and dimethyl ether by dehydration- hydrolysis of a feed mixture of methanol and methyl acetate in the presence of at least one catalyst to generate a crude reaction product comprising acetic acid and dimethyl ether wherein the feed to said co-production process comprising methanol and methyl acetate comprises dimethyl ether in a total amount of 25 mol% or less based on the total feed.

PROCESS FOR THE PRODUCTION OF DIMETHYL ETHER FROM GASEOUS MIXTURES OF CARBON MONOXIDE, HYDROGEN AND METHYL ACETATE

A process for the production of dimethyl ether from gaseous mixtures of carbon monoxide, hydrogen and methyl acetate contaminant comprising contacting a gaseous mixture of carbon monoxide, hydrogen and methyl acetate contaminant in a first scrubbing zone with a first portion of methanol to recover a scrubbed gaseous mixture depleted in methyl acetate and a first used methanol stream containing methyl acetate; contacting the scrubbed gaseous mixture in a second scrubbing zone with a second portion of methanol to recover a scrubbed gaseous mixture further depleted in methyl acetate and a second used methanol stream containing no methyl acetate or a reduced amount of methyl acetate compared to the first used methanol stream; dehydrating at least a portion of the second used methanol stream in the presence of at least one catalyst to produce a crude dehydration reaction product comprising dimethyl ether, unconverted methanol and water; recovering from the crude dehydration product a water stream ...

PROCESS FOR THE CARBONYLATION OF DIMETHYL ETHER

Production of methyl acetate by carbonylating a dimethyl ether feed with carbon monoxide under substantially anhydrous conditions, in the presence of a mordenite catalyst which contains copper and/or silver and 0.05 to 10 mol % platinum relative to aluminium.

PROCESS FOR THE CARBONYLATION OF DIMETHYL ETHER

A process for preparing methyl acetate by the carbonylation of dimethyl ether with carbon monoxide in the presence of hydrogen and a zeolite catalyst wherein, in a first step the carbonylation is conducted with a carbon monoxide to hydrogen molar ratio of at least 1 and in a second and subsequent step, the carbonylation is conducted with a hydrogen to carbon monoxide molar ratio of greater than 1.

INTEGRATED PROCESS FOR THE PRODUCTION OF METHYL ACETATE AND METHANOL FROM SYNTHESIS GAS AND DIMETHYLETHER

An integrated process for the production of methyl acetate and methanol by the carbonylating dimethyl ether with synthesis gas, recovering methyl acetate and unreacted synthesis gas and wherein the recovered synthesis gas is utilized as the sole fresh synthesis gas for methanol synthesis.

PROCESS FOR THE PRODUCTION OF METHYL ACETATE/ACETIC ACID

A process for the production of methyl acetate and/or acetic acid by contacting a carbon monoxide-containing gas and methanol and/or reactive derivatives thereof with a mordenite loaded with copper and silver loaded by ion-exchange and subsequently regenerating the catalyst.

IMPROVED CATALYTIC PERFORMANCE IN PROCESSES FOR PREPARING ACETIC ACID

PROCESS FOR THE CO-PRODUCTION OF ACETIC ACID AND DIMETHYL ETHER

METHOD OF DIRECT PRODUCTION OF METHYL ACETATE AND/OR ACETIC ACID FROM SYNTHESIS GAS-

Stable acetyl salicyclic acid salts - having anti-inflammatory, anti-pyretic and analgesic props.

PROCESS FOR MANUFACTURE OF ESTERS OF CARBOXYLIC ACIDS

PREPARATION D'ESTERS ALCOXYETHYLIQUES

PROCEDE DE PREPARATION D'ESTERS ALCOXYETHYLIQUES R(OCHCH)OOCR. IL CONSISTE A FAIRE REAGIR UN ACIDE CARBOXYLIQUE RCOOH AVEC UN ETHER MONOALKYLIQUE DE L'ETHYLENE GLYCOL R(OCHCH)OH, EN PRESENCE D'UN SYSTEME CATALYTIQUE HETEROGENE CONSTITUE DE RESINES ECHANGEUSES D'ANIONS.

NEW SALT OF ACID ACETYLSALICYLIQUE, ITS METHOD OF PREPARATION AND ITS APPLICATIONS THERAPEUTIC

Procede de preparation d'acetate de methyle a partir de formiate de methyle

L'invention a pour objet un procede de preparation d'acetate de methyle a partir de formiate de methyle, caracterise en ce que l'on fait reagir le formiate de methyle a une temperature de 170 a 220 °C en presence de : a) un catalyseur a base de rhodium, b) un promoteur iode choisi parmi les iodures alcalins ou alcalino-terreux et les composes covalents d'iode, c) un solvant choisi parmi la N-methylpyrrolidone, une amide tertiaire et une lactone, le promoteur iode etant present en une proportion molaire par rapport au catalyseur de 25 a 250.

CO-OXYDATION OF METHYLBENZENES AND BENZALDEHYDE

METHOD OF PREPARATION Of A-CETOXY OR A-PROPIONYLOXY-PROPIONALDEHYDE

Manufacturing method of high purity butyl acetate from industrial waste butyl acetate and high purity butyl acetate manufactured by the same

디메틸 에테르의 카르보닐화 방법

... 수소 및 제올라이트 촉매의 존재 하에 일산화탄소에 의한 디메틸 에테르의 카르보닐화에 의하는 메틸 아세테이트의 제조 방법으로서, 제 1 단계에서 카르보닐화가 1 이상의 일산화탄소 대 수소 몰비로 수행되고, 제 2 후속 단계에서 카르보닐화가 1 초과의 수소 대 일산화탄소 몰비로 수행되는 방법.

Integrated process for the production of methanol and methyl acetate

An integrated process for the production of methyl acetate and methanol by the carbonylating dimethyl ether with synthesis gas, recovering methyl acetate and unreacted synthesis gas and wherein the recovered synthesis gas is utilized as the sole fresh synthesis gas for methanol synthesis.

CYCLOHEXANE DERIVATIVES

Cyclohexane derivatives of formula R1-A1-Z1-A2-R2 in which R1 and R2 in each case are H, an alkyl group with 1-10 C atoms, in which also one or two non-neighboring CH2 groups can be replaced by O atoms and/or -CO groups and/or -CO-O groups and/or -CH=CH groups, F, Cl, Br, CN or R3-A3-Z2-, A1 is -A-, A4-Zo-A- or -A-Zo-A4-, A is an unsubstituted cyclohexylene group, or a trans-1,4-cyclohexylene or 1,4-cyclohexenylene group substituted in 2nd, 3rd, 5th and/or 6th position once, or more than once by F and/or Cl and/or Br and/or CN and/or an alkyl group or a fluoridated alkyl group, each having 1-10 C atoms, in which also one or two non-neighboring CH2 groups can be replaced by O atoms and/or -CO groups and/or -CO-O groups, which cyclohexylene or cyclohexenylene group, as the case may be, also can be substituted in the 1st or 4th position, in which one or two CH2 groups are replaced by -CO-, or R1-A1- is a cyclohexyl group substituted in 3rd position by an alkyl group with 1-10 C atoms, in which ...

Process for producing methyl acetate from methyl formate

The object of the invention is a process for the preparation of methyl acetate starting from the methyl formate, characterized in that methyl formate is converted at a temperature of 170° to 220° C. in the presence of: a) a catalyst based on rhodium, b) an iodine-containing promoter selected from among the alkaline, alkaline earth, phosphonium or ammonium iodides and the mixtures of covalent compounds of iodine supplemented with a phosphine or a tertiary amine. c) a solvent selected from a cyclic N-alkyl amide.

PROCESS FOR PREPARING ESTERS BY REACTING A MONOBASIC ORGANIC ACID WITH A SECONDARY ALKYL HALIDE

Carbonylation process for the production of methyl acetate

A process for the production of methyl acetate by carbonylating at a temperature of 250 to 350° C., in the presence of a zeolite catalyst, a feed comprising dimethyl ether, a gas comprising carbon monoxide and hydrogen at a molar ratio of hydrogen to carbon monoxide of at least 1, methyl acetate and one or more compounds containing a hydroxyl functional group.

Novel compositons and methods

Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, and their use in the treatment and/or prevention of diseases and disorders.

5-ACETOXY-(E3)-3-PENTENYL METHOXYMETHYL ETHER AND METHOD FOR PREPARING (E3)-3-ALKENYL ACETATE USING THE SAME

Provided are 5-acetoxy-(E3)-3-pentenyl methoxymethyl ether which can be prepared in conventional reaction equipment and a method for preparing an (E3)-3-alkenyl acetate by using it. More specifically, 5-hydroxy-(E3)-3-pentenyl methoxymethyl ether obtained by reacting 4-formyl-(E3)-3-butenyl methoxymethyl ether with a reductant is reacted with an acetylating agent to prepare 5-acetoxy-(E3)-3-pentenyl methoxymethyl ether. (E3)-3-alkenyl methoxymethyl ether obtained by a coupling reaction between the 5-acetoxy-(E3)-3-pentenyl methoxymethyl ether and a Grignard reagent is treated with an acid, and then reacted with an acetylating agent to prepare the (E3)-3-alkenyl acetate. 1. 5-Acetoxy-(E3)-3-pentenyl methoxymethyl ether.2. A method for preparing 5-acetoxy-(E3)-3-pentenyl methoxymethyl ether comprising at least the steps of:reacting 4-formyl-(E3)-3-butenyl methoxymethyl ether with a reductant to obtain 5-hydroxy-(E3)-3-pentenyl methoxymethyl ether; andreacting the 5-hydroxy-(E3)-3-pentenyl methoxymethyl ether with an acetylating agent.3. A method for preparing an (E3)-3-alkenyl acetate comprising at least the steps of:subjecting 5-acetoxy-(E3)-3-pentenyl methoxymethyl ether to a coupling reaction with a Grignard reagent represented by the following formula:RMgX{'sub': '1-20', 'wherein R represents a Clinear, branched or cyclic hydrocarbon group which may have optional one or more double bonds and X represents a halogen atom,'}so that the 5-acetoxy group is replaced by R to obtain (E3)-3-alkenyl methoxymethyl ether;treating the (E3)-3-alkenyl methoxymethyl ether with an acid to obtain (E3)-3-alkenyl alcohol; andreacting the (E3)-3-alkenyl alcohol with an acetylating agent to obtain the (E3)-3-alkenyl acetate.4. The method according to claim 3 , wherein the Grignard reagent is (Z3 claim 3 ,Z6)-3 claim 3 ,6-nonadienylmagnesium halide and the (E3)-3-alkenyl acetate is (E3 claim 3 ,Z8 claim 3 ,Z11)-3 claim 3 ,8 claim 3 ,11-tetradecatrienyl acetate.5. The method according to ...

GGA AND GGA DERIVATIVES COMPOSITIONS THEREOF AND METHODS FOR TREATING NEURODEGENERATIVE DISEASES INCLUDING PARALYSIS INCLUDING THEM

This invention relates to geranylgeranyl acetone (GGA) derivatives and the use of GGA, its isomers, and GGA derivatives in methods for inhibiting neural death, increasing neural activity, increasing axon growth and cell viability, and increasing the survival rate of subjects administered the GGA or GGA derivatives. 3. A novel compound of Table 1 or a pharmaceutically acceptable salt thereof.4. A pharmaceutical composition comprising a compound of and a pharmaceutically acceptable excipient.5. A pharmaceutical composition comprising a sufficient amount of 5E claim 1 , 9E claim 1 , 13E geranylgeranyl acetone or a GGA derivative of claim 1 , and optionally at least one pharmaceutical excipient claim 1 , wherein the sufficient amount is an amount which provides for a dosing of about 1 mg/kg/day to about 12 mg/kg/day to the patient.6. The pharmaceutical composition of claim 5 , wherein the 5E claim 5 , 9E claim 5 , 13E geranylgeranyl acetone is synthetic 5E claim 5 , 9E claim 5 , 13E geranylgeranyl acetone.7. A composition for increasing the expression and/or release of one or more neurotransmitters from a neuron at risk of developing pathogenic protein aggregates associated with AD or ALS claim 5 , said composition comprising a protein aggregate inhibiting amount of GGA or a GGA derivative.8. A composition for increasing the expression and/or release of one or more neurotransmitters from a neuron at risk of developing extracellular pathogenic protein aggregates claim 5 , said composition comprising an extracellular protein aggregate inhibiting amount of GGA or a GGA derivative.10. The method of claim 10 , wherein said pre-contacted neuron exhibits one or more of:(i) a reduction in the axon growth ability,(ii) a reduced expression level of one or more neurotransmitters,(iii) a reduction in the formation of synapses, and(iv) a reduction in electrical excitability.11. The method of claim 9 , wherein the neurostimulation comprises one or more of:(i) enhancing or inducing ...

CRYSTALLINE PHASES OF 5,6-DICHLORO-2-(ISOPROPYLAMINO)-(1-ß-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE

The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy. 1. A crystalline solvate of 5 ,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole , including a stoichiometric ratio of an organic solvent within a cavity of the crystal lattice , said solvent being selected from the group of: methanol , acetonitrile , ethyl acetate , diethylether , n-butylacetate , or 1-propanol , or mixtures thereof.2. Crystalline Form VI of 5 ,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole , wherein said compound has unit cell parameters a=b=9.2825 Å , c=41.602 Å , and P422 space group (recorded at 296 K). The present application is a continuation of U.S. patent application Ser. No. 13/282,510, filed Oct. 27, 2011, which claims the benefit of U.S. Provisional Patent Application No. 61/407,622, filed Oct. 28, 2010, the entire disclosures of which are incorporated by reference herein.The present invention relates to an unsolvated crystalline form, various solvates, and the HCl monohydrate salt of the antiviral compound 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (also known as 1263W94; maribavir; a compound of formula (I) below), pharmaceutical formulations comprising such crystalline form, solvates and the HCl monohydrate, and their use in therapy.5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (1263W94; maribavir) is a benzimidazole derivative useful in medical therapy. U.S. Pat. No. 6,077,832 discloses 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole and its use for the treatment or prophylaxis of viral infections such as those caused by herpes viruses. The compound as disclosed in U.S. Pat. No. 6,077,832 is an amorphous, non-crystalline material.The structure of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole ...

PROCESS FOR THE PREPARATION OF ENOLATE SALTS OF 4-FLUORO-2-HYDROXYMETHYLENE-3 OXO-BUTYRATES

Enolate salts of 4-fluoro-2-hydroxymethylene-3-oxobutyrates of formula wherein Ris Calkyl, Rand Rare independently hydrogen or fluorine, M is an alkali or alkaline earth metal, and n is 1 or 2, are prepared from enolate salts of the corresponding 4-fluoro-3-oxobutyrates and carbon monoxide. The enolate salts of formula I can be alkylated or acylated to obtain the corresponding enol ethers and esters. The 4-fluoro-3-oxobutyrate starting material can be prepared from 1,1-difluoroethyl methyl ethers by SbF-catalyzed fluoromethane elimination followed by halogen exchange with lithium chloride, reacting the thus obtained fluoroacetyl chloride with ketene and quenching with the appropriate alcohol R—OH. 3. The process of claim 1 , wherein the enolate salt of the 4-fluoro-3-oxobutyrate (II) is prepared in situ from the corresponding 4-fluoro-3-oxobutyrate and a strong base of the corresponding metal M.4. The process of claim 3 , wherein the strong base is an alkoxide of formula{'br': None, 'sup': n+', '1', '−, 'sub': 'n', 'M(OR)\u2003\u2003(V),'}{'sup': '1', 'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'wherein R, M and n are as defined in .'}5. The process of claim 1 , wherein M is sodium and n is 1.6. The process of claim 1 , wherein Ris Calkyl.7. The process of claim 1 , wherein Ris fluorine and Ris hydrogen.8. The process of claim 1 , wherein the enolate salt of the 4-fluoro-2-hydroxymethylene-3-oxobutyrate (I) is obtained in solid form.10. The process of claim 9 , wherein steps (i) to (iv) in the synthesis of the enolate salt of formula II are conducted without isolating the intermediates of formulae VII claim 9 , VIII and IX.11. The process of claim 9 , wherein step (ii) in the synthesis of the enolate salt of formula II is conducted in the presence of a phase transfer catalyst.13. The solid enolate salt of claim 12 , wherein M is sodium and n is 1.14. The solid enolate salt of claim 12 , wherein Ris Calkyl.15. The solid enolate salt of claim 12 , wherein Ris ...

Process for the preparation of esters by means of carbonylation of ethers

The invention relates to a process comprising the process steps of: a) initially charging an ether having from 3 to 30 carbon atoms; b) adding a phosphine ligand and a compound comprising Pd, or adding a comprising Pd and a phosphine ligand; c) feeding in CO; d) heating the reaction mixture, with conversion of the ether; wherein the phosphine ligand is a compound of formula (I) where m and n are each independently 0 or 1; R 1 , R 2 , R 3 , R 4 are each independently selected from —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —(C 6 -C 20 )-aryl, —(C 3 -C 20 )-heteroaryl; at least one of the R 1 , R 2 , R 3 , R 4 radicals is a —(C 3 -C 20 )-heteroaryl radical; and R 1 , R 2 , R 3 , R 4 , if they are —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —(C 6 -C 20 )-aryl or —(C 3 -C 20 )-heteroaryl, may each independently be substituted by one or more substituents selected from —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —O—(C 1 -C 12 )-alkyl, —O—(C 1 -C 12 )-alkyl-(C 6 -C 20 )-aryl, —O—(C 3 -C 12 )-cycloalkyl, —S—(C 1 -C 12 )-alkyl, —S—(C 3 -C 12 )-cycloalkyl, —COO—(C 1 -C 12 )-alkyl, —COO—(C 3 -C 12 )-cycloalkyl, —CONH—(C 1 -C 12 )-alkyl, —CONH—(C 3 -C 12 )-cycloalkyl, —CO—(C 1 -C 12 )-alkyl, —CO—(C 3 -C 12 )-cycloalkyl, —N—[(C 1 -C 12 )-alkyl] 2 , —(C 6 -C 20 )-aryl, —(C 6 -C 20 )-aryl-(C 1 -C 12 )-alkyl, —(C 6 -C 20 )-aryl-O—(C 1 -C 12 )-alkyl, —(C 3 -C 20 )-heteroaryl, —(C 3 -C 20 )heteroaryl-(C 1 -C 12 )-alkyl, —(C 3 -C 20 )-heteroaryl-O—(C 1 -C 12 )-alkyl, —COOH, —SO 3 H, —NH 2 , halogen; and wherein no alcohol is added to the reaction mixture.

Process for the alkoxycarbonylation of ethers

The invention relates to a process comprising the following process steps: a) introducing an ether having 3 to 30 carbon atoms; b) adding a phosphine ligand and a compound which comprises Pd, or adding a complex comprising Pd and a phosphine ligand; c) adding an alcohol; d) supplying CO; e) heating the reaction mixture, the ether being reacted for form an ester; where the phosphine ligand is a compound of formula (I) where m and n are each independently 0 or 1; R 1 , R 2 , R 3 , R 4 are each independently selected from —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —(C 6 -C 20 )-aryl, —(C 3 -C 20 )-heteroaryl; at least one of the R 1 , R 2 , R 3 , R 4 radicals is a —(C 3 -C 20 )-heteroaryl radical; and R 1 , R 2 , R 3 , R 4 , if they are —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —(C 6 -C 20 )-aryl or —(C 3 -C 20 )-heteroaryl, may each independently be substituted by one or more substituents selected from —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —O—(C 1 -C 12 )-alkyl, —O—(C 1 -C 12 )-alkyl-(C 6 -C 20 )-aryl, —O—(C 3 -C 12 )-cycloalkyl, —S—(C 1 -C 12 )-alkyl, —S—(C 3 -C 12 )-cycloalkyl, —COO—(C 1 -C 12 )-alkyl, —COO—(C 3 -C 12 )-cycloalkyl, —CONH—(C 1 -C 12 )-alkyl, —CONH—(C 3 -C 12 )-cycloalkyl, —CO—(C 1 -C 12 )-alkyl, —CO—(C 3 -C 12 )-cycloalkyl, —N—[(C 1 -C 12 )-alkyl] 2 , —(C 6 -C 20 )-aryl, —(C 6 -C 20 )-aryl-(C 1 -C 12 )-alkyl, —(C 6 -C 20 )-aryl-O—(C 1 -C 12 )-alkyl, —(C 3 -C 20 )-heteroaryl, —(C 3 -C 20 )-heteroaryl-(C 1 -C 12 )-alkyl, —(C 3 -C 20 )-heteroaryl-O—(C 1 -C 12 )-alkyl, —COOH, —OH, —SO 3 H, —NH 2 , halogen.

Process for the alkoxycarbonylation of olefins in a medium having a low brønsted acid concentration

Process comprising the following process steps: a) introducing an ethylenically unsaturated compound; b) adding a ligand-metal complex comprising Pd and a bidentate phosphine ligand, or adding a bidentate phosphine ligand and a compound which comprises Pd; c) adding an alcohol; d) supplying CO; e) heating the reaction mixture, the ethylenically unsaturated compound being reacted to form an ester, where the reaction mixture is admixed with less than 0.1 mol %, based on the amount of substance of the ethylenically unsaturated compound, of Brønsted acids having an acid strength of pKa ≦3, characterized in that the phosphine ligand is substituted on at least one phosphorus atom by at least one heteroaryl radical.

Process for the alkoxycarbonylation of alcohols

The invention relates to a process comprising the following process steps: a) introducing a first alcohol, the first alcohol having 2 to 30 carbon atoms; b) adding a phosphine ligand and a compound which comprises Pd, or adding a complex comprising Pd and a phosphine ligand; c) adding a second alcohol; d) supplying CO; e) heating the reaction mixture, the first alcohol reacting with CO and the second alcohol to form an ester; where the phosphine ligand is a compound of formula (I) where m and n are each independently 0 or 1; R 1 , R 2 , R 3 , R 4 are each independently selected from —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —(C 6 -C 20 )-aryl, —(C 3 -C 20 )-heteroaryl; at least one of the R 1 , R 2 , R 3 , R 4 radicals is a —(C 3 -C 20 )-heteroaryl radical; and R 1 , R 2 , R 3 , R 4 , if they are —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —(C 6 -C 20 )-aryl or —(C 3 -C 20 )-heteroaryl, may each independently be substituted by one or more substituents selected from —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —O—(C 1 -C 12 )-alkyl, —O—(C 1 -C 12 )-alkyl-(C 6 -C 20 )-aryl, —O—(C 3 -C 12 )-alkyl, —S—(C 1 -C 12 )-alkyl, —S—(C 3 -C 12 )-cycloalkyl, —COO—(C 1 -C 12 )-alkyl, —COO—(C 3 -C 12 )-cycloalkyl, —CONH—(C 1 -C 12 )-alkyl, —CONH—(C 3 -C 12 )-cycloalkyl, —CO—(C 1 -C 12 )-alkyl, —CO—(C 3 -C 12 )-cycloalkyl, —N—[(C 1 -C 12 )-alkyl] 2 , —(C 6 -C 20 )-aryl, —(C 6 -C 20 )-aryl-(C 1 -C 12 )-alkyl, —(C 6 -C 20 )-aryl-O—(C 1 -C 12 )-alkyl, —(C 3 -C 20 )-heteroaryl, —(C 3 -C 20 )-heteroaryl-(C 1 -C 12 )-alkyl, —(C 3 -C 20 )-heteroaryl-O—(C 1 -C 12 )-alkyl, —COON, —OH, —SO 3 H, —NH 2 , halogen.

1, 1' -bis(phosphino)ferrocene ligands for alkoxycarbonylation

Diastereomer mixture comprising diastereomers of the formulae (I.1) and (I.2) where R 2 , R 4 are each independently selected from —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —(C 6 -C 20 )-aryl; the R 1 , R 3 radicals are each a —(C 3 -C 20 )-heteroaryl radical; R 1 , R 3 may each independently be substituted by one or more substituents selected from —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —O—(C 1 -C 12 )-alkyl, —O—(C 1 -C 12 )-alkyl-(C 6 -C 20 )-aryl, —O—(C 3 -C 12 )-cycloalkyl, —S—(C 1 -C 12 )-alkyl, —S—(C 3 -C 12 )-cycloalkyl, —COO—(C 1 -C 12 )-alkyl, —COO—(C 3 -C 12 )-cycloalkyl, —CONH—(C 1 -C 12 )-alkyl, —CONH—(C 3 -C 12 )-cycloalkyl, —CO—(C 1 -C 12 )-alkyl, —CO—(C 3 -C 12 )-cycloalkyl, —N—[(C 1 -C 12 )-alkyl] 2 , —(C 6 -C 20 )-aryl, —(C 6 -C 20 )-aryl-(C 1 -C 12 )-alkyl, —(C 6 -C 20 )-aryl-O—(C 1 -C 12 )-alkyl, —(C 3 -C 20 )-heteroaryl, —(C 3 -C 20 )-heteroaryl-(C 1 -C 12 )-alkyl, —(C 3 -C 20 )-heteroaryl-O—(C 1 -C 12 )-alkyl, —COOH, —OH, —SO 3 H, —NH 2 , halogen; and R 2 , R 4 , if they are —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl or —(C 6 -C 20 )-aryl, may each independently be substituted by one or more substituents selected from —(C 1 -C 12 )-alkyl, —(C 3 -C 12 )-cycloalkyl, —(C 3 -C 12 )-heterocycloalkyl, —O—(C 1 -C 12 )-alkyl, —O—(C 1 -C 12 )-alkyl-(C 6 -C 20 )-aryl, —O—(C 3 -C 12 )-cycloalkyl, —S—(C 1 -C 12 )-alkyl, —S—(C 3 -C 12 )-cycloalkyl, —COO—(C 1 -C 12 )-alkyl, —COO—(C 3 -C 12 )-cycloalkyl, —CONH—(C 1 -C 12 )-alkyl, —CONH—(C 3 -C 12 )-cycloalkyl, —CO—(C 1 -C 12 )-alkyl, —CO—(C 3 -C 12 )-cycloalkyl, —N—[(C 1 -C 12 )-alkyl] 2 , —(C 6 -C 20 )-aryl, —(C 6 -C 20 )-aryl-(C 1 -C 12 )-alkyl, —(C 6 -C 20 )-aryl-O—(C 1 -C 12 )-alkyl, —(C 3 -C 20 )-heteroaryl, —(C 3 -C 20 )-heteroaryl-(C 1 -C 12 )-alkyl, —(C 3 -C 20 )-heteroaryl-O—(C 1 -C 12 )-alkyl, —COOH, —OH, —SO 3 H, —NH 2 , halogen. The invention further relates to Pd complex mixtures ...

FRAGRANCE AND FLAVOR COMPOSITIONS CONTAINING ISOMERIC ALKADIENYL ESTERS

A composition containing at least one isomeric alkadienyl ester in an amount effective to impart a fragrance or flavor to the composition. A fragrance or flavor composition containing at least one isomeric alkadienyl ester in an amount effective to impart a fragrance or flavor to the composition. A consumer product containing the fragrance or flavor composition having at least one isomeric alkadienyl ester in an amount effective to impart a fragrance or flavor to the composition. A method of imparting a fragrance or flavor to a consumer product by adding to the consumer product a fragrance or flavor composition containing at least one isomeric alkadienyl ester in an amount effective to impart a fragrance or flavor to the consumer product. 1. A composition comprising at least one isomeric alkadienyl ester in an amount effective to impart a fragrance or flavor to the composition.2. The composition of wherein the at least one isomeric alkadienyl ester is selected from the group consisting of Z claim 1 ,E-3 claim 1 ,5-heptadienyl formate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl acetate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl propionate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl butyrate claim 1 , and Z claim 1 ,E-3 claim 1 ,5-heptadienyl isobutyrate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl valerate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl isovalerate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl hexanoate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl benzoate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl lactate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl pyruvate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl salicylate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl tiglate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl methyl carbonate claim 1 , Z claim 1 ,E-3 claim 1 ,5-heptadienyl cis-3-hexenoate claim 1 , and Z claim 1 ,E-3 claim 1 ,5-heptadienyl alpha methyl butyrate.3. The composition of wherein the at least one ...

PROCESS FOR CARBONYLATING DIMETHYL ETHER

A process for the production of methyl acetate by carbonylating dimethyl ether with carbon monoxide at a temperature of 250 to 350° C. in the presence of a zeolite catalyst and hydrogen such that the molar ratio of hydrogen to carbon monoxide is at least 1, and one or more compounds containing a hydroxyl functional group and in the absence of any added methyl acetate. 1. A process for the production of methyl acetate by carbonylation of dimethyl ether which process comprises contacting in a reactor dimethyl ether with carbon monoxide in the presence of a zeolite catalyst and hydrogen at a temperature of from 250 to 350° C. and at a molar ratio of hydrogen to carbon monoxide of at least 1 , and wherein the process further comprises introducing into the reactor at least one compound containing a hydroxyl functional group and the process is carried out in the absence of added methyl acetate.2. A process according to wherein the zeolite is a templated zeolite.3. A process according to wherein the hydroxyl compound(s) is introduced into the reactor in a total amount of up to 1 mol % based on the total gaseous feed to the process.4. A process according to wherein the total amount of hydroxyl compound(s) is from 0.01 to 0.5 mol % based on the total gaseous feed to the process.5. A process according to claim 1 , wherein the one or more hydroxyl compound(s) is selected from aliphatic alcohols claim 1 , aliphatic carboxylic acids claim 1 , water and mixtures thereof.6. A process according to wherein the hydroxyl compound is a C-Caliphatic alcohol.7. A process according to wherein the hydroxyl compound is a C-Caliphatic carboxylic acid.8. A process according to wherein the hydroxyl compound is selected from one or more of acetic acid claim 5 , methanol and water.9. A process according to claim 1 , wherein the molar ratio of hydrogen to carbon monoxide is in the range 1.5 to 4:1.10. A process according to claim 1 , wherein the catalyst is a zeolite having at least one channel ...

CELL SEEDING PLATE, METHOD FOR MANUFACTURING THE SAME, AND CELL SHEET SEPARATING METHOD

A cell seeding plate comprises a substrate and a photolysis layer formed on a surface of the substrate. The photolysis layer comprises a plurality of photolysis groups, and each of the plurality of photolysis groups has a chemical structural formula of 2. The cell seeding plate of claim 1 , wherein the substrate is transparent claim 1 , and made of plastic or glass.3. The cell seeding plate of claim 1 , wherein Ris a natural polymer comprising sulfur group or a synthetic polymer comprising sulfur group claim 1 , the natural polymer is selected from collagen claim 1 , hyaluronic acid claim 1 , protein for functionalizing cell claim 1 , or peptides for functionalizing cell.6. The method of claim 5 , wherein the substrate is transparent claim 5 , and made of plastic or glass.9. The cell sheet separating method of claim 8 , wherein the substrate is transparent claim 8 , and made of plastic or glass. The subject matter herein generally relates to a cell seeding plate, a method for manufacturing the cell seeding plate, and a cell sheet separating method using the cell seeding plate.Cells are usually seeded on a thermoresponsive plate to form a cell sheet. The whole thermoresponsive plate can be deformed when cooled, thus allowing the cell sheet to be separated from the thermoresponsive plate. However, an activity of the cells may be decreased when cooled.It will be appreciated that for simplicity and clarity of illustration, where appropriate, reference numerals have been repeated among the different figures to indicate corresponding or analogous elements. In addition, numerous specific details are set forth in order to provide a thorough understanding of the embodiments described herein. However, it will be understood by those of ordinary skill in the art that the embodiments described herein can be practiced without these specific details. In other instances, methods, procedures, and components have not been described in detail so as not to obscure the related relevant ...

ERYTHROMYCIN ETHYLSUCCINATE CRYSTALLINE HYDRATE, PREPARATION AND USES THEREOF

Disclosed is an anti-infective drug-macrolide derivate, preparation and uses thereof. Macrolide derivate, namely erythromycin ethylsuccinate crystalline hydrate, which has less moisture absorption and good storage stability, can be used in the preparation of medicaments for the treatment and prevention of human or animal infectious diseases caused by Gram-positive or negative bacteria. 1. A macrolide derivative , characterized in that the macrolide derivative is an erythromycin ethylsuccinate crystalline hydrate of a general formula of CHNO.nHO , n=0.20 to 0.6.2. The erythromycin ethylsuccinate crystalline hydrate according to claim 1 , characterized in that the erythromycin ethylsuccinate hydrate is erythromycin ethylsuccinate 0.25 HO hydrate.3. The erythromycin ethylsuccinate crystalline hydrate according to claim 1 , characterized in that the erythromycin ethylsuccinate hydrate is erythromycin ethylsuccinate 0.5 HO hydrate.4. A process for the preparation of macrolide derivative-erythromycin ethylsuccinate crystalline hydrate according to claim 1 , the process comprising:{'sub': 1', '6', '2', '6', '3', '8', '2', '8', '1', '6', '2', '6', '2', '8', '3', '8', '1', '6, 'method A. in a reaction vessel, one or more of a C-Clower alcohol, a C-Clower nitrile, a C-Clower ketone or C-Clower ether is used as a solvent, to the solvent is added erythromycin, stirred at a temperature of 0-50° C. to dissolve erythromycin; to the solution is added sodium bicarbonate or sodium carbonate or potassium carbonate, and water, stirred, and cooled to 20° C. or below; to the cooled mixture is added monoethyl succinate halide, including monoethyl succinate chloride or monoethyl succinate bromide, allowed to react, and monitored by TLC until the reaction is complete; to the resultant is added an acid or a base to control the pH value at about 7.0-8.5; the organic phase is precipitated and separated; to the organic phase is added water, cooled to −20° C.-10° C.; upon the solid is ...

COOLANT COMPOSITION AND COOLING SYSTEM

This disclosure provides a nonaqueous coolant composition excellent in insulation property and heat transfer characteristic. The embodiment is a coolant composition that includes at least one carboxylic acid ester compound as a nonaqueous base and is substantially free of water. 1. A coolant composition comprisingat least one carboxylic acid ester compound as a nonaqueous base,wherein the coolant composition is substantially free of water.2. The coolant composition according to claim 1 ,wherein the carboxylic acid ester compound comprises at least one selected from the group consisting of an aliphatic carboxylic acid ester compound and an aromatic carboxylic acid ester compound, the aliphatic carboxylic acid ester compound is an ester of a saturated or unsaturated aliphatic carboxylic acid having 2 to 30 carbon atoms and a saturated or unsaturated fatty alcohol having 1 to 30 carbon atoms, and the aromatic carboxylic acid ester compound is an ester of an aromatic carboxylic acid having 6 to 20 carbon atoms and a saturated or unsaturated fatty alcohol having 1 to 30 carbon atoms.3. The coolant composition according to claim 1 ,wherein the carboxylic acid ester compound comprises at least one selected from an aliphatic carboxylic acid ester compound, the aliphatic carboxylic acid ester compound is an ester of a saturated or unsaturated aliphatic carboxylic acid having 2 to 30 carbon atoms and a saturated or unsaturated fatty alcohol having 1 to 30 carbon atoms.4. The coolant composition according to claim 1 ,wherein the carboxylic acid ester compound comprises at least one selected from an aromatic carboxylic acid ester compound, the aromatic carboxylic acid ester compound is an ester of an aromatic carboxylic acid having 6 to 20 carbon atoms and a saturated or unsaturated fatty alcohol having 1 to 30 carbon atoms.5. The coolant composition according to claim 1 ,wherein the saturated or unsaturated fatty alcohol comprises a monohydric alcohol.6. The coolant ...

NOVEL COMPOUND, AND FLAVOR COMPOSITION AND/OR FRAGRANCE COMPOSITION CONTAINING SAME

The present invention addresses the problem of providing a novel compound capable of imparting a highly appealing floral and verdant scent, and a flavor composition and/or fragrance composition containing the same. This compound is a racemic or optically active compound represented by general formula (1). 2. A flavor composition and/or fragrance composition comprising the racemic or optically active compound represented by the general formula (1) according to .3. A product imparted with a scent claim 2 , wherein the flavor composition and/or fragrance composition according to is combined with at least one product selected from the group consisting of beverages claim 2 , foods claim 2 , flagrances or cosmetics claim 2 , toiletry products claim 2 , air care products claim 2 , daily necessities and household goods claim 2 , compositions for oral use claim 2 , hair care products claim 2 , skin care products claim 2 , body care products claim 2 , detergents for clothing claim 2 , soft finishing agents for clothing claim 2 , quasi drugs claim 2 , and drugs.4. A method for improving a scent of a flavor and/or fragrance claim 1 , comprising adding the racemic or optically active compound represented by the general formula (1) according to . The present invention relates to a novel compound having a 3,5,5-trimethylheptane structure, a flavor composition and/or fragrance composition containing the compound, a fragrance or cosmetic, toiletry product, bathing agent, beverage, food, quasi drug, or drug containing the flavor composition and/or fragrance composition, and a method for strengthening a scent of a flavor and/or fragrance.In recent years, with the diversification of various food ingredients, food additives, beverages, foods (including favorite foods), fragrances or cosmetics, sanitation materials, sundries, drugs, and the like, formerly unknown new demands have been increasing for a flavor and/or fragrance used therein, and development of flavor substance and/or ...

Process for the co-production of acetic acid and dimethyl ether

A process for the co-production of acetic acid and dimethyl ether with reduced formic acid content by distilling a mixture comprising dimethyl ether, methanol and methyl formate; separating methyl formate from the mixture to recover dimethyl ether and methanol; and catalytically reacting the methanol and methyl acetate to produce a reaction product of acetic acid an dimethyl ether.

INTERMEDIATES FOR THE VITAMIN A SYNTHESIS

Processes for synthesizing new compounds that may usefully be employed in organic synthesis, especially in the synthesis of vitamin A or β-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin are disclosed. The new compounds are especially useful as intermediates (building blocks) in the synthesis of vitamin A or β-carotene, preferably vitamin A. 121-. (canceled)27. The process according to claim 26 , wherein step (ii) is conducted under an inert gas atmosphere.28. The process according to claim 26 , wherein step (ii) is carried out at an elevated temperature above 30° C.29. The process according to claim 28 , wherein the elevated temperature is in a range of 30° C. to 80° C.30. The process according to claim 26 , wherein step (ii) is carried out in the presence of a tertiary amine.31. The process according to claim 30 , wherein the tertiary amine comprises trimethylamine.32. The process according to claim 26 , wherein step (ii) is carried out in the presence of at least one nucleophilic catalyst.33. The process according to claim 32 , wherein the at least one nucleophilic catalyst comprises dimethyl aminopyridine.34. The process according to claim 26 , wherein the organic solvent of step (iii) is selected from the group consisting of tetrahydrofuran (THF) claim 26 , toluene claim 26 , methyl-tetrahydrofuran claim 26 , methyl cyclopentyl ether claim 26 , tert-butyl methyl ether claim 26 , tert-butyl ethyl ether claim 26 , tert-amyl methyl ether and mixtures thereof.35. The process according to claim 26 , wherein step (iii) is carried out in the presence of bis(acetonitrile)-dichloropalladium or bis(benzonitrile)-dichloropalladium as catalyst.36. The process according to claim 26 , wherein step (iii) is practiced to obtain a yield of the compound of formula (I) based on the compound of formula (II) is more than 50%. This application is a continuation of U.S. patent application Ser. No. 16/645,614 filed on Mar. 9, 2020 (now abandoned), which ...

Process for the preparation of beta-santalol

The present invention concerns a process for the preparation of a compound of formula (I) in the form of any one of its stereoisomers or mixtures thereof, wherein R represents a C 2 -C 10 group of formula COR a wherein R a is an alkyl or alkenyl group optionally comprising one or two ether functional groups or is a phenyl or benzyl group optionally substituted by one to three alkyl, alkoxyl, carboxyl, acyl, amino or nitro groups or halogen atoms.

Layer-Separation Method of Spent Caustic Solution

Provided are a layer-separation method of a spent caustic solution, and a recycling method of an additive, and more particularly, a layer-separation method of a spent caustic solution including: injecting an additive and an acidic compound to the spent caustic solution occurring from a refinery process to break down a red oil emulsion and to perform layer-separation into an upper layer fraction and a lower layer fraction, wherein the additive is an aliphatic hydrocarbon compound having a water solubility of 0.1 to 10 g/L at 20° C. 1. A layer-separation method of a spent caustic solution comprising:injecting an additive and an acidic compound to the spent caustic solution occurring from a refinery process to break down a red oil emulsion and to perform layer-separation into an upper layer fraction and a lower layer fraction,wherein the additive is an aliphatic hydrocarbon compound having a water solubility of 0.1 to 10 g/L at 20° C.2. The layer-separation method of claim 1 , wherein the aliphatic hydrocarbon compound is an aliphatic alcohol compound having 8 to 10 carbon atoms or an aliphatic ester compound having 6 to 10 carbon atoms.3. The layer-separation method of claim 2 , wherein the aliphatic alcohol compound is any one or two or more selected from 1-octanol claim 2 , and 2-ethyl-1-hexanol claim 2 , and the aliphatic ester compound is any one or two or more selected from butyl acetate claim 2 , pentyl acetate claim 2 , hexyl acetate claim 2 , and propyl propionate.4. The layer-separation method of claim 1 , wherein a volume ratio of the spent caustic solution to the additive is 99.9 to 80:0.1 to 20.5. The layer-separation method of claim 1 , wherein the spent caustic solution is adjusted to have a pH of 1 to 5 by injecting an acidic compound.6. The layer-separation method of claim 1 , wherein the red oil emulsion is formed by a compound including any one or two or more selected from a phenol-based compound and a naphthenic acid-based compound.7. A recycling ...

COMPOUND USEFUL FOR PREVENTING OR TREATING IRRITABLE BOWEL SYNDROME AND COMPOSITION INCLUDING SAME

The present invention provides a compound of formula (I) or a prodrug thereof useful for treating or preventing irritable bowel syndrome, and a composition comprising the compound as an active ingredient. Also, the present invention provides a method for treating or preventing irritable bowel syndrome, which comprises administrating a therapeutically or prophylactically effective amount of the compound or the composition to a subject in need of treating or preventing irritable bowel syndrome. 13-. (canceled)5. The compound of claim 4 , wherein Ris acetyl; Ris hydroxyl; and R claim 4 , Rand Rare H—.6. The compound of claim 5 , which is (6E claim 5 ,12E)-3-hydroxytetradeca-6 claim 5 ,12-dien-8 claim 5 ,10-diyn-1-yl acetate.7. A pharmaceutical composition claim 4 , comprising the compound or salt thereof of and a pharmaceutically acceptable excipient.8. The pharmaceutical composition of claim 7 , wherein Ris acetyl; Ris hydroxyl; and R claim 7 , Rand Rare H—.9. The pharmaceutical composition of claim 8 , wherein the compound is (6E claim 8 ,12E)-3-hydroxytetradeca-6 claim 8 ,12-dien-8 claim 8 ,10-diyn-1-yl acetate.10. The pharmaceutical composition of claim 8 , comprising 0.1 to 20 weight % of the compound of claim 8 , based on the total weight of the pharmaceutical composition.11. The pharmaceutical composition of claim 7 , which is an oral composition.12. A method for treating irritable bowel syndrome claim 7 , comprising:{'claim-ref': {'@idref': 'CLM-00004', 'claim 4'}, 'administering to a patient a therapeutically effective amount of the compound or salt thereof of .'}13. The method of claim 12 , wherein the compound is (6E claim 12 ,12E)-3-hydroxytetradeca-6 claim 12 ,12-dien-8 claim 12 ,10-diyn-1-yl acetate.14. The method of claim 12 , wherein the compound is administered to inhibit at least one selected from NK2 receptor claim 12 , motilin receptor claim 12 , melanocortin MC1 receptor and cannabinoid CB2 receptor.15. The method of claim 12 , wherein the compound ...

2-(2,4,5-TRIMETHYLCYCLOHEX-2-EN-1-YL)ACETALDEHYDE AND DERIVATIVES AND THEIR USE AS AROMA CHEMICALS

The present invention relates to 2-(2,4,5-trimethylcyclohex-2-en-1-yl)acetaldehyde and derivatives thereof, to a process for preparing said compounds, to the use of 2-(2,4,5-trimethylcyclohex-2-en-1-yl)acetaldehyde or a specific derivative thereof or of mixtures of said compounds or of a stereoisomer thereof or of a mixture of two or more stereoisomers thereof as aroma chemicals; to the use of 2-(2,4,5-trimethylcyclohex-2-en-1-yl)acetaldehyde or a specific derivative thereof for modifying the scent character of a fragranced composition; to compositions containing 2-(2,4,5-trimethylcyclohex-2-en-1-yl)acetaldehyde or a specific derivative thereof or a mixture of said compounds or a stereoisomer thereof or a mixture of two or more stereoisomers thereof; and to a method of preparing a fragranced composition or for modifying the scent character of a fragranced composition, comprising incorporating 2-(2,4,5-trimethylcyclohex-2-en-1-yl)-acetaldehyde or a specific derivative thereof or a mixture of said compounds or a stereoisomer thereof or a mixture of two or more stereoisomers thereof into said composition. 125.-. (canceled)27. The compound according to claim 26 , where the compounds of formula (I) have at least one of the following features a) to c){'sup': '1', 'a) Ris hydrogen or methyl,'}{'sup': 2', '3, 'b) Rand R, independently of each other, are methyl or ethyl,'}{'sub': 1', '2', '3, 'c) X represents a group X, Xor X.'}28. The compound according to claim 26 , where X represents a group X claim 26 , Xor X.29. The compound according to claim 28 , where in XRis hydrogen claim 28 , methyl or ethyl and in XRis methyl or ethyl.32. The compound according to claim 30 , where Ris C-C-alkyl.35. A mixture of compounds comprising two or three compounds selected from:{'claim-ref': {'@idref': 'CLM-00030', 'claim 30'}, 'a compound of the general formula (II), a stereoisomer thereof or a mixture of stereoisomers thereof, as defined in ,'}{'claim-ref': {'@idref': 'CLM-00033', 'claim ...

PROCESSES FOR PREPARING ZINCOALUMINOSILICATES WITH AEI, CHA, AND GME TOPOLOGIES AND COMPOSITIONS DERIVED THEREFROM

The present disclosure is directed to methods of producing zincoaluminosilicate structures with AEI, CHA, and GME topologies using organic structure directing agents (OSDAs), and the compositions and structures resulting from these methods. 1. A crystalline microporous zincoaluminosilicate solid having a CHA or GME topology.2. The crystalline microporous zincoaluminosilicate solid of claim 1 , having a GME topology and a molar ratio of Si:Al in a range of from 3 to about 200 and molar ratio of Si:Zn in a range from 5 to 50.3. The crystalline microporous zincoaluminosilicate solid of claim 1 , having a CHA topology and a molar ratio of Si:Al in a range of from 4 to 100 and molar ratio of Si:Zn in a range from 5 to 50.4. The crystalline microporous zincoaluminosilicate solid of claim 1 , exhibiting at least one of the following:{'figref': {'@idref': 'DRAWINGS', 'FIG. 9'}, '(a) an XRD pattern the same as or consistent with any one of those shown in (Zn—Al-GME and Zn—Al-CHA); or'}(b) an XRD pattern having at least the five major peaks substantially as provided in Table 2.8. The crystalline microporous zincoaluminosilicate solid of claim 6 , wherein the quaternary piperidinium cation of Formula (I) comprises a cis-N claim 6 ,N-dimethyl-3 claim 6 ,5-lupetidinium cation claim 6 , trans-N claim 6 ,N-dimethyl-3 claim 6 ,5-lupetidinium cation claim 6 , cis-N claim 6 ,N-dimethyl-2 claim 6 ,6-lupetidinium cation claim 6 , trans-N claim 6 ,N-dimethyl-2 claim 6 ,6-lupetidinium cation or a combination thereof.10. The crystalline microporous zincoaluminosilicate solid of claim 9 , wherein R claim 9 , R claim 9 , or Rare all methyl.11. The crystalline microporous zincoaluminosilicate solid of whose micropores are substantially free of organic structure directing agent.12. The crystalline microporous zincoaluminosilicate solid of claim 1 , comprising pores that contain:{'sub': 4-n', 'n, '(a) Li, Na, K, Rb, Cs, Be, Mg, Ca, Sr, Be, Al, Ga, In, Zn, Ag, Cd, Ru, Rh, Pd, Pt, Au, Hg, La, Ce ...

Reaction Method Accompanied by Production of Gas Component

The present invention relates to a reaction method comprising a step of supplying a liquid containing at least one raw material compound and a low-boiling compound having a standard boiling point lower than a standard boiling point of the raw material compound to a flow channel, a step of heating the liquid to produce a liquid reaction product and a gas component by a reaction of the raw material compound, and a step of separating a liquid phase containing the reaction product from a gas phase containing the gas component and the low-boiling compound. 1. A reaction method accompanied by production of a gas component , comprising:a step of supplying a liquid containing at least one raw material compound and a low-boiling compound having a standard boiling point lower than a standard boiling point of the raw material compound to a flow channel;a step of heating the liquid to produce a liquid reaction product and a gas component by a reaction of the raw material compound; anda step of separating a liquid phase containing the reaction product from a gas phase containing the gas component and the low-boiling compound.2. The method according to claim 1 , wherein a stoichiometric proportion of the raw material compound to the reaction product in the liquid is raw material compound:reaction product=100:0 to 80:20.3. The method according to claim 1 , wherein the flow channel has a specific surface area of 10 m/mor more and less than 1000 m/m.4. The method according to claim 1 , wherein the low-boiling compound is collected as a component contained in the gas phase and/or the liquid phase.5. The method according to claim 1 , wherein the gas phase containing the gas component and the low-boiling compound is produced in the flow channel.6. The method according to claim 1 , wherein the standard boiling point of the low-boiling compound is lower than the standard boiling point of the raw material compound by 10° C. or more.7. The method according to claim 1 , wherein the gas ...

METHOD FOR SYNTHEZISING CYCLOHEXENONES FOR USE IN THE PERFUME INDUSTRY AND COMPOUNDS OBTAINED THEREBY

Cyclohexenone and cyclohexenol compounds are provided having specific fragrances and remanence properties, along with methods for synthesizing these compounds, including obtaining the compound by condensing a ketone on an α-methylene-aldehyde in order to obtain, by means of a domino reaction, compounds of formula (II) as follows: 2. The compound according to wherein R3 is either a cyclopentyl group substituted by one or more alkyl groups claim 1 , or a cyclopentenyl group substituted by one or more alkyl groups.3. The compound according to wherein R3 is an alkyl or alkenyl group claim 1 , optionally substituted by an aryl.4. The compound according to wherein Z═C(O).5. The compound according to wherein Z═CR4(OR5) with R4 represents a hydrogen or a C1-C8 alkyl or C2-C8 alkenyl group claim 1 , and R5 represents a hydrogen.6. A composition comprising at least one compound of general formula (II) such as defined in claim 1 , in the form of a stereoisomer or of a mixture of stereoisomers claim 1 , or of a racemic mixture.7. The composition according to further comprising at least one additional fragrancing substance.8. The composition according to wherein the compound of formula (II) is present in a concentration of between 0.1 and 99% by weight relative to the total weight of the composition.9. The composition according to wherein the compound of formula (II) is present in a concentration of between 0.1 and 30% by weight relative to the total weight of the composition.10. A fragrant agent or a flavoring agent comprising the compound of and an acceptable fragrant agent or flavoring agent carrier.11. A masking agent of odors and/or flavors comprising the compound of and an acceptable masking agent carrier.12. A pharmaceutical claim 1 , cosmetic claim 1 , or food composition comprising the compound according to in combination with perfuming ingredients claim 1 , flavoring ingredients claim 1 , solvents claim 1 , additives claim 1 , or fixatives.13. A method for conferring ...

1-HYDROXYMETHYL-1,2,2,6-TETRAMETHYL-CYCLOHEXANE AND DERIVATIVES THEREOF AND THEIR USE AS AROMA CHEMICALS

The invention relates to compounds of formula (A) as defined herein, and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to a method for preparing compounds of formula (A) and esters of the compound of formula (A), and ketones of the compound of formula (A). The invention further relates to the use of at least one compound selected from compounds of formula (A) and the esters of a compound of formula (A) and the ketones of a compound of formula (A) as aroma chemical. 7. The method according to claim 5 , for preparing a compound of formula (A.b) claim 5 , wherein in step iib) claim 5 , the nucleophilic agent is selected from metal C-C-alkyl compounds and metal C-C-alkenyl compounds claim 5 , which comprise at least one ligand R.10. The use of a compound according to as aroma chemical.13. The perfumed or aromatized product according to claim 12 , wherein the product is preferably selected from scent dispensers and fragrances perfumes claim 12 , detergents and cleaners claim 12 , cosmetic compositions claim 12 , body care compositions claim 12 , hygiene articles claim 12 , products for oral and dental hygiene claim 12 , scent dispensers claim 12 , fragrances claim 12 , pharmaceutical compositions and crop protection compositions. Despite a large number of existing aroma chemicals (fragrances and flavorings), there is a constant need for new components in order to be able to satisfy the multitude of properties desired for extremely diverse areas of application. These include, firstly, the organoleptic properties, i.e. the compounds should have advantageous odiferous (olfactory) or gustatory properties. Furthermore, aroma chemicals should, however, also have additional positive secondary properties, such as e.g. an efficient preparation method, the possibility of providing better sensory profiles as a result of synergistic effects with other fragrances, a higher stability under certain application ...

Chemical liquid purification method and chemical liquid

An object of the present invention is to provide a chemical liquid purification method which makes it possible to obtain a chemical liquid having excellent defect inhibition performance. Another object of the present invention is to provide a chemical liquid. The chemical liquid purification method according to an embodiment of the present invention is a chemical liquid purification method including obtaining a chemical liquid by purifying a substance to be purified containing an organic solvent, in which a content of the stabilizer in the substance to be purified with respect to the total mass of the substance to be purified is equal to or greater than 0.1 mass ppm and less than 100 mass ppm.

Shelf life mass polymerizable polycycloolefin compositions as optical materials

Embodiments in accordance with the present invention encompass compositions encompassing a latent organo-ruthenium compound and a pyridine compound along with one or more monomers which undergo ring open metathesis polymerization (ROMP) when said composition is exposed to suitable actinic radiation to form a substantially transparent film. Surprisingly, the compositions are very stable at ambient conditions to temperatures up to 80° C. for several days and undergo mass polymerization when subject only to actinic radiation. Accordingly, compositions of this invention are useful in various opto-electronic applications, including as 3D printing materials, coatings, encapsulants, fillers, leveling agents, among others.

ORGANIC TREATMENT LIQUID FOR PATTERNING RESIST FILM, METHOD OF PRODUCING ORGANIC TREATMENT LIQUID FOR PATTERNING RESIST FILM, STORAGE CONTAINER OF ORGANIC TREATMENT LIQUID FOR PATTERNING RESIST FILM, PATTERN FORMING METHOD USING THE SAME, AND METHOD OF PRODUCING ELECTRONIC DEVICE

An organic treatment liquid for patterning a resist film, in which a metal element concentration of each of Na, K, Ca, Fe, Cu, Mg, Mn, Li, Al, Cr, Ni, and Zn is 3 ppm or less and which can reduce generation of particles, in a negative tone pattern forming method for forming a miniaturized (for example, 30 nm node or less) pattern by particularly using an organic developer, a method of producing the organic treatment liquid for patterning a resist film, a storage container of the organic treatment liquid for patterning a resist film, a pattern forming method using the same, and a method of producing an electronic device can be provided. 1. An organic treatment liquid for patterning a resist film ,wherein a metal element concentration of each of Na, K, Ca, Fe, Cu, Mg, Mn, Li, Al, Cr, Ni, and Zn is 3 ppm or less.2. A method of producing the organic treatment liquid according to claim 1 , comprising:a distillation step.3. The method of producing the organic treatment liquid according to claim 2 ,wherein a lining is applied on an inner surface of a condenser used in the distillation step.4. The method of producing the organic treatment liquid according to claim 2 ,wherein a lining is applied on an inner surface of a distillation device used in the distillation step.5. The method of producing the organic treatment liquid according to claim 2 , further comprising:a step of transferring a distillate obtained in the distillation step through a flow path having an inner wall on which a lining is applied.6. The method of producing the organic treatment liquid according to claim 2 , further comprising:a step of transferring a distillate obtained in the distillation step through a flow path of which an inner wall is formed of a fluorine-containing resin.7. The method of producing the organic treatment liquid according to claim 3 ,wherein a lining substance in the lining is a fluorine-containing resin.8. The organic treatment liquid according to claim 1 ,wherein the organic ...

SILICON-CONTAINING RESIN COMPOSITION

A silicon-containing resin composition with which it is possible to form a silica-based coating film in which generation of cracks is minimized, a method for forming a silica-based coating film using the silicon-containing resin composition, and a crack-free silica-based coating film formed using the silicon-containing resin composition. The silicon-containing resin composition includes a silicon-containing resin and a solvent, in which one or more of siloxane resins and polysilanes is used as the silicon-containing resin, and the solvent contains a cycloalkyl acetate having a specific structure. 2. The silicon-containing resin composition according to claim 1 , further comprising a curing agent.3. A method for forming a silica-based coating film claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'applying the silicon-containing resin composition according to to a substrate to form a coating film; and'}baking the coating film.4. The method for forming a silica-based coating film according to claim 3 , wherein the silica-based coating film has a film thickness of 0.01 to 20 μm.5. A method for forming a silica-based coating film claim 3 , comprising:{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, 'applying the silicon-containing resin composition according to to a substrate to form a coating film; and'}baking the coating film.6. The method for forming a silica-based coating film according to claim 5 , wherein the silica-based coating film has a film thickness of 0.01 to 20 μm. The present invention relates to a silicon-containing resin composition, a method for forming a silica-based coating film using the silicon-containing resin composition, and a crack-free silica-based coating film formed using the silicon-containing resin composition.Silica-based coating films are used in various applications, for example, interlayer insulating films in various elements, sealing materials in light-emitting devices such as LED devices and organic EL devices, ...

Novel process for making omega-aminoalkylenic alkyl ester

A method for making a compound of formula (V): is provided. The method comprises converting a compound of formula (III): to the compound of formula (V), wherein A is a C 6 -C 10 alkene group having at least one carbon-carbon double bond, B is a C 6 -C 10 alkyl chain; and R 1 is an alkyl group, and R 3 is an oxygenated functional group.

FLAVOR AND FRAGRANCE FORMULATION (IV)

The present invention relates to the use of specific organic compounds as flavor and fragrance material. Furthermore the invention relates to new specific organic compounds, as well as to flavor and fragrance formulations comprising at least one of the specific organic compounds. 4. Use according to claim 1 , wherein at least one compound selected from the group consisting of compounds of formulae (II) claim 1 , (V) claim 1 , (VI) and (VII) is used.7. Flavor and fragrance formulation according to comprising 0.0001-10 wt-% claim 5 , related to the total weight of the flavor and fragrance formulation claim 5 , of at least one compound of formula (I).8. Flavor and fragrance formulation according to claim 5 , wherein the flavor and fragrance formulation is solid claim 5 , gel-like or liquid.9. Flavor and fragrance formulation according to claim 5 , wherein the flavor and fragrance formulation is a perfume claim 5 , air care product claim 5 , household product claim 5 , laundry product claim 5 , body care product or cosmetic product. The present invention relates to the use of specific organic compounds as flavor and fragrance material. Furthermore the invention relates to new specific organic compounds, as well as to flavor and fragrance formulations comprising at least one of the specific organic compound.In the flavor and fragrance industry there is always a need and demand for compounds that enhance, modify, improve or otherwise positively influence an odor note and therefore giving perfumers or other persons the ability to create new fragrances for perfumes, colognes, personal care products, household products or any other products, which comprise flavor and fragrance materials.Surprisingly it was found that the compounds of formula (I) are very useful as flavor and fragrance material.Therefore the present invention is related to the use of a compound of formula (I)wherein Rsignifies —H (hydrogen), or —CH(methyl), and Rsignifies a moietyor Rsignifies methyl (=“—CH ...

2,3,7-TRIMETHYLOCT-6-ENYL ACETATE AND 3,7-DIMETHYL-2-METHYLENE-OCT-6-ENYL ACETATE AND DERIVATIVES THEREOF AND THEIR USE AS AROMA CHEMICALS

The present invention relates to 2,3,7-Trimethyloct-6-enyl acetate and 3,7-dimethyl-2-methylene-oct-6-enyl acetate and derivatives thereof and their use as aroma chemicals. 4. A composition comprising at least two compounds as defined in selected from the compound of the formula (I).5. The composition according to claim 4 , wherein the compounds are selected from the compound of the formula (I.a1) claim 4 , (I.a2) claim 4 , (I.a3) and (I.a4).6. The composition according to claim 4 , comprising at least one compound selected from the compound of the formula (I.a1) claim 4 , (I.a2) claim 4 , (I.a3) and (I.a4) and at least one compound selected from the compound of the formula (I.b1) and (I.b2).7. The composition according to claim 4 , wherein the compounds are selected from the compound of the formula (I.b1) and (I.b2) claim 4 , with the proviso that a composition consists only of the racemate of compound of (I.b1) and (I.b2) is excluded.8. The composition according to claim 6 , wherein the compounds are selected from the compound of the formula (I.b1) and (I.b2) claim 6 , wherein one compound (I.b1) or (I.b2) is present in an amount of at least 60% by weight claim 6 , based on the total weight of compound (I.b1) and (I.b2).11. Use of a compound of the formula (I) according to as aroma chemical.12. The use according to claim 11 , whereasi) the compound of formula (I.a) is used for preparing a fragrance and/or aroma having a note of herbaceous, green, technical, natural, fresh impression, floral, freesia, watery, sweet, pleasantly fresh and/or watery-ozone.13. The use according to claim 11 , whereasii) the compound of formula (I.b) is used for preparing a fragrance and/or aroma having a note of floral, rose and/or waxy.15. The use according to claim 14 , whereasi) the compound of formula (II.b) is used for preparing a fragrance and/or aroma having a note of citrus, and/orii) the compound of formula (II.c) is used for preparing a fragrance and/or aroma having a note of ...

BEER-TASTE BEVERAGE, METHOD FOR PRODUCING BEER-TASTE BEVERAGE, AND METHOD FOR IMPROVING AROMA OF BEER-TASTE BEVERAGE

Provided is a beer-taste beverage in which oxidized soy sauce odor is changed to good aroma, a method for producing the beer-taste beverage, and a method for improving aroma of the beer-taste beverage. The beer-taste beverage according to the present invention has an a* value in an L*a*b* color system of 7.0 to 21.0, and an acetate ester content of 0.7 to 2.4 mg/L. The method for producing the beer-taste beverage according to the present invention includes producing the beverage so that the a* value in the L*a*b* color system is 7.0 to 21.0 and the acetate ester content is 0.7 to 2.4 mg/L. In the method for improving the aroma of the beer-taste beverage according to the present invention, the beer-taste beverage is prepared so that the a* value in the L*a*b* color system is 7.0 to 21.0 and the acetate ester content is 0.7 to 2.4 mg/L. 1. A beer-taste beverage , which has an a* value in an L*a*b* color system of 7.0 or more and 21.0 or less and a content of acetate ester of 0.7 mg/L or more and 2.4 mg/L or less.2. The beer-taste beverage according to claim 1 , wherein the a* value is 11.0 or more and 21.0 or less.3. The beer-taste beverage according to claim 1 , wherein the a* value is 7.0 or more and 16.0 or less.4. The beer-taste beverage according to claim 1 , wherein the content of the acetate ester is 1.0 mg/L or more and 2.0 mg/L or less.5. The beer-taste beverage according to claim 1 , wherein the acetate ester is isoamyl acetate.6. The beer-taste beverage according to claim 1 , wherein the beer-taste beverage has an L* value of 50.0 or more and 90.0 or less and a b* value of 50.0 or more and 90.0 or less.7. The beer-taste beverage according to claim 1 , wherein the beer-taste beverage contains no colorant.8. The beer-taste beverage according to claim 1 , wherein the beer-taste beverage has a malt ratio of 50 mass % or more.9. A beer-taste beverage claim 1 ,wherein the beer-taste beverage has an a* value in an L*a*b* color system of 11.0 or more and 16.0 or ...

Branched-Chain Esters and Methods of Making and Using the Same

Branched-chain esters and methods of making branched-chain esters are generally disclosed. Various uses of such compounds are also disclosed, including uses in personal care compositions and lubricant compositions. In some embodiments, the branched-chain esters are at least partially derived from a renewable source, such as a natural oil. 2. The compound of claim 1 , wherein Ris Calkyl or Calkenyl claim 1 , each of which can be optionally substituted one or more times by substituents selected independently from the group consisting of: a halogen atom claim 1 , —OH claim 1 , —O(Calkyl) claim 1 , —NH claim 1 , —NH(Calkyl) claim 1 , and —N(Calkyl).3. The compound of claim 1 , wherein Ris Calkyl or Calkenyl claim 1 , each of which is optionally substituted one or more times with —OH.4. The compound of claim 1 , wherein Ris hexyl claim 1 , heptyl claim 1 , octyl claim 1 , nonyl claim 1 , decyl claim 1 , undecyl claim 1 , dodecyl claim 1 , tridecyl claim 1 , tetradecyl claim 1 , pentadecyl claim 1 , hexadecyl claim 1 , or heptadecyl.5. The compound of claim 1 , wherein Ris nonyl or undecyl.6. The compound of claim 1 , wherein Ris hydrogen.7. The compound of claim 1 , wherein Rand Rare independently Calkyl or Calkenyl claim 1 , each of which can be optionally substituted one or more times by substituents selected independently from the group consisting of: a halogen atom claim 1 , —OH claim 1 , —O(Calkyl) claim 1 , —NH claim 1 , —NH(Calkyl) claim 1 , and —N(Calkyl).8. The compound of claim 7 , wherein Rand Rare independently Calkyl or Calkenyl claim 7 , each of which is optionally substituted one or more times with —OH.9. The compound of claim 7 , wherein Rand Rare independently propyl claim 7 , butyl claim 7 , pentyl claim 7 , hexyl claim 7 , heptyl claim 7 , octyl claim 7 , nonyl claim 7 , decyl claim 7 , undecyl claim 7 , dodecyl claim 7 , tridecyl claim 7 , tetradecyl claim 7 , pentadecyl claim 7 , hexadecyl claim 7 , or heptadecyl.10. The compound of claim 7 , wherein ...

Process for Extracting Polyester from an Article

A process for extracting polyester from an article using a solvent system comprising a compound according to any of general Formula I to VI wherein Rand Rare each independently selected from: hydrogen, alkyl, alkenyl, alkynyl, aryl or alkoxy groups; Rto Rare each independently selected from: hydrogen, alkyl, alkenyl, alkynyl, aryl or alkoxy groups; X is selected from O or S; and each of a to e is a carbon atom, wherein the total linear chain length of a-b-c-d-e is in the range of 2 to 5 carbons; Rand Rare both independently aryl groups; R, R, R, Rand Rare each independently selected from hydrogen, alkyl, alkenyl, alkynyl or aryl groups; n is an integer in the range of 1 to 8; m is 3; and 1 is an integer in the range of 1 to 3; or combination thereof. 2. A process according to claim 1 , wherein the article is fabric.3. A process according to claim 1 , wherein the article is clothing.4. A process according to claim 1 , wherein the article is plastics bottles.5. A process according to claim 1 , wherein the polyester is selected from: Polyglycolic acid (PGA) claim 1 , Polylactic acid (PLA) claim 1 , Polycaprolactone (PCL) claim 1 , Polyethylene adipate (PEA) claim 1 , Polyhydroxyalkanoate (PHA) claim 1 , Polyethylene terephthalate (PET) claim 1 , Polybutylene terephthalate (PBT) claim 1 , Polytrimethylene terephthalate (PTT) claim 1 , Polyethylene naphthalate (PEN) or combination thereof.6. A process according to a claim 5 , wherein the polyester is polyethylene terephthalate.7. A process according to claim 1 , wherein the solvent system is homogeneous.8. A process according to claim 1 , wherein the solvent system comprises one or more compounds according to any of general formulae Ito VI in an amount in the range 30% to 100% by mass of the total mass of the composition.9. A process according to claim 8 , wherein the solvent system comprises one or more compounds according to any of general formulae I to VI in an amount of at least 90% by mass of the total mass of the ...

Method for Producing Asymmetric Conjugated Diyne Compound and Method for Producing Z,Z-Conjugated Diene Compound Using the Same

Provided are a method for efficiently producing an asymmetric conjugated diyne from an inexpensive and safe alternative compound to hydroxylamine hydrochloride and a method for producing a Z,Z-conjugated diene compound from the asymmetric conjugated diyne compound thus obtained. More specifically, provided is a method for producing an asymmetric conjugated diyne compound comprising a step of subjecting a terminal alkyne compound (1): HC≡C—Z 1 —Y 1 to a coupling reaction with an alkynyl halide (2) Y 2 —Z 2 —C≡C—X by using sodium borohydride in water and an organic solvent in the presence of a copper catalyst and a base to obtain the asymmetric conjugated diyne compound (3): Y 2 —Z 2 —C≡C—C≡C—Z 1 —Y 1 . In addition, provided is a method for producing a Z,Z-conjugated diene compound by reducing the resulting asymmetric conjugated diyne compound, or the like.

Perfume systems

The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles.

ANTIMICROBIAL, ANTIBACTERIAL AND SPORE GERMINATION INHIBITING ACTIVITY FROM AN AVOCADO EXTRACT ENRICHED IN BIOACTIVE COMPOUNDS

The present disclosure relates to extracts from sp. (avocado) enriched in bioactive compounds which can be used as antimicrobial, antibacterial or spore germination inhibiting agents, the process for obtaining the extracts, acetogenins and isolated molecules and methods for using the extracts enriched in bioactive compounds for providing antimicrobial, antibacterial or spore germination inhibiting effect. 117-. (canceled)23Clostridium, Bacillus, Alicyclobacillus. The method of claim 18 , wherein the method is carried out to inhibit germination of bacterial spores selected from the group consisting of claim 18 , and combinations thereof.24Clostridium botulinum, Clostridium perfringens, Clostridium difficile, Bacillus anthracis, Bacillus cereus, Bacillus subtilis, Bacillus lichinformis, Alicyclobacillus acidoterrestris, Alicyclobacillus acidophilus. The method of claim 18 , wherein the method is carried out to inhibit germination of bacterial spores selected from the group consisting of claim 18 , and combinations thereof.25. The method of claim 18 , wherein the method is carried out to inhibit germination of heat shocked bacterial spores.26. The method of claim 18 , wherein the product is a food product.27. The method of claim 26 , wherein the food product is selected from the group consisting of fish claim 26 , crustaceans claim 26 , fish substitutes claim 26 , crustacean substitutes claim 26 , meat claim 26 , meat substitutes claim 26 , poultry products claim 26 , vegetables claim 26 , greens claim 26 , sauces claim 26 , emulsions claim 26 , beverages claim 26 , juices claim 26 , wines claim 26 , beers claim 26 , dairy products claim 26 , egg-based products claim 26 , jams claim 26 , jellies claim 26 , grain-based products claim 26 , baked goods claim 26 , confectionary products claim 26 , and combinations thereof.28. The method of claim 27 , wherein the food product is a ready to eat food product stored under refrigerated conditions.29. The method of claim 18 , ...

ESTER DERIVATIVES OF ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE

Compounds having a structure of Structure I: 2. The compound of claim 1 , wherein Ris halo.3. The compound of claim 1 , wherein Ris fluoro.4. The compound of claim 1 , wherein each Ris independently methyl claim 1 , ethyl or propyl.5. The compound of claim 1 , wherein each Ris methyl.9. A pharmaceutical composition claim 1 , comprising: a compound according to ; anda pharmaceutically acceptable carrier.10. A pharmaceutical composition claim 1 , comprising: a compound according to ; a pharmaceutically acceptable carrier; and an additional therapeutic agent.11. The pharmaceutical composition of claim 10 , wherein the additional therapeutic agent is for treating prostate cancer claim 10 , breast cancer claim 10 , ovarian cancer claim 10 , endometrial cancer claim 10 , salivary gland carcinoma claim 10 , hair loss claim 10 , acne claim 10 , hirsutism claim 10 , ovarian cysts claim 10 , polycystic ovary disease claim 10 , precocious puberty claim 10 , spinal and bulbar muscular atrophy claim 10 , or age-related macular degeneration.12. The pharmaceutical composition of claim 10 , wherein the additional therapeutic agent is enzalutamide claim 10 , Galeterone claim 10 , ARN-509; abiraterone claim 10 , bicalutamide claim 10 , nilutamide claim 10 , flutamide claim 10 , cyproterone acetate claim 10 , docetaxel claim 10 , Bevacizumab (Avastin) claim 10 , OSU-HDAC42 claim 10 , VITAXIN claim 10 , sunitumib claim 10 , ZD-4054 claim 10 , Cabazitaxel (XRP-6258) claim 10 , MDX-010 (Ipilimumab) claim 10 , OGX 427 claim 10 , OGX 011 claim 10 , finasteride claim 10 , dutasteride claim 10 , turosteride claim 10 , bexlosteride claim 10 , izonsteride claim 10 , FCE 28260 claim 10 , SKF105 claim 10 ,111 claim 10 , radium 233 claim 10 , or related compounds thereof.13. A method for modulating androgen receptor activity claim 1 , comprising: administering a compound according to to a patient in need thereof.14. A method for treating a condition or disease that is responsive to modulation of ...

Process For The Preparation Of Hyperpolarized Carboxylate Compounds

The present invention relates to a process for the preparation of aqueous solutions of [1-C]-hyperpolarized carboxylate containing molecules of diagnostic interest that comprises parahydrogenating with molecular parahydrogen unsaturated alkenyl or alkynyl esters of the concerned C-carboxylate molecules. 1. A Para-Hydrogen Induced Polarization process for a preparation of an [1-C]-hyperpolarized carboxylate containing molecule comprising hydrogenating with molecular para-hydrogen an unsaturated C-Calkenyl or alkynyl ester of said carboxylate containing molecule.2. A process according to wherein the unsaturated C-Calkenyl or alkynyl ester is selected from the group consisting of vinyl claim 1 , allyl and propargyl esters.3. A process according to wherein the unsaturated ester has the following general formula (II){'br': None, 'R—C.(O)—O—R′\u2003\u2003(II)'}in which:{'sup': 13', '13', '13, 'C. denotes the naturally C enriched or, optionally, C labeled carboxylate carbon atom undergoing C hyperpolarization;'}R′ is a vinyl, an allyl or a propargyl residue;{'sub': 1', '5', '1, 'R is a C-Clinear or branched alkyl chain which is, optionally, interrupted by, or substituted with one or more groups selected from the group consisting of carbonyl (—CO—), hydroxyl (—OH), amino group(s) of formula —NHR, halogen atom(s), halo-alkyl group(s), and carbocyclic aliphatic moieties and aromatic moieties optionally substituted by one or more hydroxyl groups; and'}{'sub': '1', 'Ris H or an amino protecting group'}and physiologically acceptable salts thereof.4. A process according to wherein R is selected from the group consisting of C-Calkyl claim 3 , methylcarbonyl claim 3 , hydroxyethyl claim 3 , and aminoalkyl residue of formula R—CH(NHR)— claim 3 , in which Ris H or an amino protecting group selected from the group consisting of trifluoroacetyl claim 3 , acetyl claim 3 , benzoyl claim 3 , carbobenzoxy claim 3 , and tert-butyl carbonate claim 3 , and Ris H or C-Calkyl chain optionally ...

PERFUME SYSTEMS

The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles. 2. A perfume according to comprising claim 1 , based on total perfume weight claim 1 , from about 0.0001% to about 50% of said perfume raw material.3. A consumer product comprising the perfume according to and an adjunct ingredient.4. A consumer product comprising the perfume according to claim 2 , said consumer product being a cleaning and/or treatment composition and comprising an adjunct ingredient.5. A consumer product according to claim 4 , said consumer product being a fabric and/or hard surface cleaning and/or treatment composition claim 4 , said composition comprising claim 4 , based on total composition weight claim 4 , from about 0.00001% to about 35% of said perfume.6. A consumer product according to claim 4 , said consumer product being a detergent claim 4 , said detergent comprising claim 4 , based on total detergent weight claim 4 , from about 0.00001% to about 35% of said perfume.7. A consumer product according to claim 4 , said consumer product being a highly compacted consumer product claim 4 , said highly compacted consumer product comprising claim 4 , based on total highly compacted consumer product weight claim 4 , from about 0.00001% to about 35% of said perfume.8. A perfume delivery system comprising claim 1 , based on total delivery system weight claim 1 , from about 0.001% to about 99% of the perfume of claim 1 , said perfume delivery system being a polymer assisted delivery system; a molecule- ...

PERFUME SYSTEMS

The present application relates to perfume raw materials, perfume delivery systems and consumer products comprising such perfume raw materials and/or such perfume delivery systems, as well as processes for making and using such perfume raw materials, perfume delivery systems and consumer products. Such perfume raw materials and compositions, including the delivery systems, disclosed herein expand the perfume communities' options as such perfume raw materials can provide variations on character and such compositions can provide desired odor profiles. 1. A molecule selected from the group consisting of: 6 ,6 ,10-trimethylundec-9-en-5-one; 2-methyl-5-(4-methylpent-3-en-1-yl)furan; 3-isopropyl-3 ,6-dimethylhept-5-en-2-one; (E ,Z)-3 ,3 ,7-trimethyloct-6-en-2-one oxime; 1-(1-(4-methylpent-3-en-1-yl)cyclobutyl)propan-1-one; 2-(R ,S)-ethyl-2 ,6-dimethylhept-5-enenitrile; 3-(R ,S)-ethyl-3 ,7-dimethyloct-6-en-2-one; 6-(R ,S)-ethyl-6 ,10-dimethylundec-9-en-5-one; 3-(R ,S)-ethyl-3 ,7-dimethyloct-6-en-2-(R ,S)-ol; 2-(R ,S)-ethyl-2 ,5-dimethylhex-4-enenitrile; 3-(R ,S)-ethyl-3 ,6-dimethylhept-5-en-2-one; 3-(R ,S)-ethyl-3 ,6-dimethylhept-5-en-2-ol; 6-(R ,S)-ethyl-6 ,9-dimethyldec-8-en-5-ol; 1-(R ,S)- ,3 ,4-trimethylcyclohex-3-enecarbonitrile; 3 ,4-dimethyl-1-(R ,S)-(3-methylbut-2-en-1-yl)cyclohex-3-enecarbonitrile; 1-(3 ,4-dimethyl-1-(R ,S)-(3-methylbut-2-en-1-yl)cyclohex-3-en-1-yl)ethanone; 3 ,4-dimethyl-1-(R ,S)-(4-methylpent-3-en-1-yl)cyclohex-3-enecarbonitrile; 1-(3-ethoxy-4-hydroxyphenyl)-3-methylbutan-1-one; 1-(3-ethoxy-4-hydroxyphenyl)-2-methylbutan-1-one; 1-(3-ethoxy-4-hydroxyphenyl)-2 ,2-dimethylpropan-1-one; 1-(R ,S)-ethyl-3 ,4-dimethyl-cyclohex-3-enecarbonitrile; 1-(1-(R ,S)-ethyl-3 ,4-dimethyl-cyclohex-3-en-1-yl)ethanone; 1-(1-(R ,S)-ethyl-3 ,4-dimethyl-cyclohex-3-en-1-yl)pentan-1-one; 1-(1-(R ,S)-methyl-3 ,4-dimethyl-cyclohex-3-en-1-yl)pentan-1-ol; 1-(R ,S)allyl-3 ,4-dimethylcyclohex-3-enecarbonitrile; 1-(1-(R ,S)-allyl-3 ,4-dimethyl-cyclohex-3-en-1-yl)ethanone; 1-(1 ...

POLYFLUOROALKYL ALLYL COMPOUND AND METHOD FOR PRODUCING THE SAME

A polyfluoroalkyl allyl compound represented by the general formula: 12-. (canceled)3. A carboxylic acid allyl adduct represented by the general formula:{'br': None, 'sub': 3', '2', 'n', '2', '2', 'a', '2', '2', 'b', '2', '2, 'CF(CF)(CHCF)(CFCF)CHCHICHOCOR′\u2003\u2003[II]'}{'sub': 1', '3, 'wherein n is an integer of 0 to 5, a is 1 or 2, and b is an integer of 0 to 3, and R′ is a C-Calkyl group.'}4. A method for producing the carboxylic acid allyl adduct according to claim 3 , the method comprising reacting polyfluoroalkyl iodide represented by the general formula:{'br': None, 'sub': 3', '2', 'n', '2', '2', 'a', '2', '2', 'b, 'CF(CF)(CHCF)(CFCF)I\u2003\u2003[III]'}{'sub': 2', '2', '1', '3, 'wherein n is an integer of 0 to 5, a is 1 or 2, and b is an integer of 0 to 3, with carboxylic acid allyl R′COOCHCH═CHhaving a C-Calkyl group (R′).'} The present invention relates to a polyfluoroalkyl allyl compound and a method for producing the same. More particularly, the present invention relates to a polyfluoroalkyl allyl compound that is used as a synthetic intermediate for a fluorine-containing alkylsilane compound having a high water contact angle, and a method for producing the same.In general, compounds having a perfluoroalkyl group as a structural unit are known to improve surface modifying properties, water- and oil-repellency, mold releasability, antifouling properties, leveling properties, etc., of various substrates, such as fiber, metal, glass, rubber, and resin, by chemical treatment of the surface of each substrate.Among such compounds, telomer compounds containing a perfluoroalkyl group having 8 to 12 carbon atoms are most likely to exhibit the above properties. Telomer compounds having 8 carbon atoms are preferably used.However, it has been recently reported that perfluorooctanoic acid having 8 carbon atoms or perfluorocarboxylic acids having more than 8 carbon atoms have adverse effect on the environment, because they have low degradability and high ...

(3R) EPIMER OF OCTAHYDRO-7,7-DIMETHYL-8-METHYLENE 1H-3A, 6-METHANOAZULEN-3-YL ACETATE, COMPOSITION, SYNTHESIS PROCESS AND USE OF SAID EPIMER

The first subject matter of the invention is the (3R) epimer of octahydro-7,7-dimethyl-8-methylene-1H-3a, 6-methanoazulen-3-yl acetate [(octahydro-7,7-dimethyl-8-methylene-[3R,3aR,6R,8aR]-1H-3a,6-methanoazulen-3-yl acetate) or (R)-norzizaenylacetate] of formula I (I). The subject matter of the invention is also compositions comprising (R)norzizaenyl acetate and also a novel synthesis process and the use of said ester. 2. (R)-ziza-6(13)-en-12-yl acetate of was isolated.3. Composition containing (R)-ziza-6(13)-en-12-yl acetate at least claim 1 , with formula I.4. Composition according to claim 3 , characterized by containing ziza-6(13)-en-12-yl acetate in its (R) form only [100% (R)-ziza-6(13)-en-12-yl acetate] and does not contain ziza-6(13)-en-12-yl acetate in its (S) form [0% (S)-ziza-6(13)-en-12-yl acetate].5. Composition according to claim 3 , characterized by containing (R)-ziza-6(13)-en-12-yl acetate and (S)-ziza-6(13)-en-12-yl acetate in a weight ratio of the (R)-ziza-6(13)-en-12-yl acetate form to the (S)-ziza-6(13)-en-12-yl acetate form [(R)/(S)] greater than 1.2 claim 3 , preferably greater than 1.5.6. Synthesis method of (R)-ziza-6(13)-en-12-yl acetate claim 3 , with formula 1 claim 3 , comprised of a first step claim 3 , the reduction of khusimone in the presence of a reducing agent and an organic solvent claim 3 , and a second step claim 3 , the acetylation of the product obtained in the first step in the presence of an organic solvent.7. Method of characterized by the reducing agent being selected from lithium aluminum hydride (LiAlH) claim 6 , DiBAH (diisobutylaluminium hydride) claim 6 , sodium borohydride (NaBH) claim 6 , lithium borohydride (NaLiH) or potassium borohydride (KBH) claim 6 , preferably sodium borohydride.8. Method of claim 6 , characterized by the molar ratio [(AR)/(K)] between the reducing agent (RA) and the khusimone (K) being between 0.5 and 5 claim 6 , preferably between 1 and 3 claim 6 , more preferably equal to 2.9. Method of ...

Production of fatty olefin derivatives via olefin metathesis

In one aspect, the invention provides a method for synthesizing a fatty olefin derivative. The method includes: a) contacting an olefin according to Formula I with a metathesis reaction partner according to Formula IIb in the presence of a metathesis catalyst under conditions sufficient to form a metathesis product according to Formula IIIb: and b) converting the metathesis product to the fatty olefin derivative. Each R 1 is independently selected from H, C 1-18 alkyl, and C 2-18 alkenyl; R 2b is C 1-8 alkyl; subscript y is an integer ranging from 0 to 17; and subscript z is an integer ranging from 0 to 17. In certain embodiments, the metathesis catalyst is a tungsten catalyst or a molybdenum catalyst. In various embodiments, the fatty olefin derivative is a pheromone. Pheromone compositions and methods of using them are also described.

FLAVOR AND FRAGRANCE FORMULATION (VI)

The present invention relates to the use of specific organic compounds of formula (I) as flavor and fragrance material. Furthermore the invention relates to a new specific organic compound, as well as to flavor and fragrance formulations comprising at least one of the specific organic compounds. 4. Flavor and fragrance formulation according to comprising 0.0001-10 wt-% claim 3 , related to the total weight of the flavor and fragrance formulation claim 3 , of at least one compound of formula (I).5. Flavor and fragrance formulation according to claim 3 , wherein the flavor and fragrance formulation is solid claim 3 , gel-like or liquid.6. Flavor and fragrance formulation according to claim 3 , wherein the flavor and fragrance formulation is a perfume claim 3 , air care product claim 3 , household product claim 3 , laundry product claim 3 , body care product or cosmetic product.9. A process for the manufacture of compound (Ib) comprising the steps ofi) ethinylating 5,6-dimethyl-5-hepten-2-on to 3,6,7-trimethyl-6-octen-1-in-3-ol;ii) acylating 3,6,7-trimethyl-6-octen-1-in-3-ol to 3,6,7-trimethyl-6-octen-1-in-3-yl acetate;iii) hydrogenating the C≡C triple bond 3,6,7-trimethyl-6-octen-1-in-3-yl acetate to the saturated C—C bond in the presence of a Lindlar catalyst leading to the compound of formula (Ib). The present invention relates to the use of specific organic compounds as flavor and fragrance material. Furthermore the invention relates to new specific organic compounds, as well as to flavor and fragrance formulations comprising at least one of the specific organic compounds.In the flavor and fragrance industry there is always a need and demand for compounds that enhance, modify, improve or otherwise positively influence an odor note and therefore give perfumers or other persons the ability to create new fragrances for perfumes, colognes, personal care products, household products or any other products, which comprise flavor and fragrance materials.Surprisingly it was ...

Silicon-containing resin composition

A silicon-containing resin composition with which it is possible to form a silica-based coating film in which generation of cracks is minimized, a method for forming a silica-based coating film using the composition, and a crack-free silica-based coating film formed using the composition. The silicon-containing resin composition includes a silicon-containing resin and a solvent, in which one or more of siloxane resins and polysilanes is used as the silicon-containing resin, and the solvent contains a cycloalkyl acetate having a specific structure.

ETHERS AND ESTERS OF TERTIARY ALKANOLS FOR USE AS AROMA CHEMICALS

The present invention relates to the use of an ether or an ester of a tertiary alkanol or of mixtures of two or more ethers or esters of tertiary alkanols or of a stereoisomer thereof or of a mixture of two or more stereoisomers thereof as aromachemicals; to the use thereof for modifying the scent character of a fragranced composition; to an aroma chemical composition containing an ether or an ester of tertiary alkanol or of mixtures of two or more ethers or esters of tertiary alkanols or of a stereoisomer thereof or of a mixture of two or more stereoisomers thereof; and to a method of preparing a fragranced composition or for modifying the scent character of a fragranced composition. The invention further relates to specific ethers or esters of tertiary alkanols. 116.-. (canceled)18. The aroma chemical according to claim 17 , where Ris ethyl.19. The aroma chemical according to claim 17 , where Ris methyl or ethyl.20. The aroma chemical according to claim 17 , where Ris C-C-alkyl.21. The aroma chemical according to claim 17 , where Ris C-C-alkyl.22. The aroma chemical according to claim 21 , where Ris methyl or ethyl.23. The aroma chemical according to claim 17 , where Ris C-C-alkanoyl.24. The aroma chemical according to claim 23 , where Ris C-C-alkanoyl.25. The aroma chemical according to claim 24 , where Ris acetyl or propanoyl.26. The aroma chemical according to comprising of a mixture of two or more compounds of formula (I).27. A process for modifying a scent character or a fragranced composition which comprises utilizing the compound of formula (I) or the mixture of two or more compounds of formula (I) or the stereoisomer thereof or the mixture of two or more stereoisomers thereof claim 17 , according to in a composition.28. A composition selected from the group consisting of perfume compositions claim 17 , body care compositions claim 17 , products for oral and dental hygiene claim 17 , hygiene articles claim 17 , cleaning compositions claim 17 , textile ...

ANTIMICROBIAL, ANTIBACTERIAL AND SPORE GERMINATION INHIBITING ACTIVITY FROM AN AVOCADO EXTRACT ENRICHED IN BIOACTIVE COMPOUNDS

The present disclosure relates to extracts from sp. (avocado) enriched in bioactive compounds which can be used as antimicrobial, antibacterial or spore germination inhibiting agents, the process for obtaining the extracts, acetogenins and isolated molecules and methods for using the extracts enriched in bioactive compounds for providing antimicrobial, antibacterial or spore germination inhibiting effect. 117-. (canceled)21. A pharmaceutical composition comprising:{'claim-ref': {'@idref': 'CLM-00018', 'claim 18'}, 'the compound of and'}a pharmaceutically acceptable carrier.22. The pharmaceutical composition of claim 21 , wherein the compound is present in a concentration of at least about 7.8 μg/ml.23. The pharmaceutical composition of further comprising:an antimicrobial substance selected from the group consisting of nitrite compounds, nisin, bacteriocins, ethyl lauroyl arginate, ethylene diaminetetraacetic acid compounds, ascorbic acid compounds, benzoic acid compounds, and combinations thereof.24. A food product composition comprising:a food product and{'claim-ref': {'@idref': 'CLM-00028', 'claim 28'}, 'the compound of .'}25. The food product composition of claim 24 , wherein the compound is present in a concentration of at least about 7.8 μg/ml.26. The food product composition of claim 24 , wherein the food product is selected from the group consisting of fish claim 24 , crustaceans claim 24 , fish substitutes claim 24 , crustacean substitutes claim 24 , meat claim 24 , meat substitutes claim 24 , poultry products claim 24 , vegetables claim 24 , greens claim 24 , sauces claim 24 , emulsions claim 24 , beverages claim 24 , juices claim 24 , wines claim 24 , beers claim 24 , dairy products claim 24 , egg-based products claim 24 , jams claim 24 , jellies claim 24 , grain-based products claim 24 , baked goods claim 24 , confectionary products claim 24 , and combinations thereof.27. The food product composition of claim 24 , wherein the food product is a ready to ...

CRYSTALLINE PHASES OF 5,6-DICHLORO-2-(ISOPROPYLAMINO)-(1-BETA-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE

The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy. 1. A crystalline solvate of 5 ,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole , including a stoichiometric ratio of an organic solvent within a cavity of the crystal lattice , said solvent being selected from the group of: methanol , acetonitrile , ethyl acetate , diethylether , n-butylacetate , or 1-propanol , or mixtures thereof.2. Crystalline Form VI of 5 ,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole , wherein said compound has unit cell parameters a=b=9.2825 Å , c=41.602 Å , and P422 space group (recorded at 296 K). The present application is a division of U.S. patent application Ser. No. 13/875,489, filed May 2, 2013, which is a continuation of U.S. patent application Ser. No. 13/282,510, filed Oct. 27, 2011, which claims the benefit of U.S. Provisional Patent Application No. 61/407,622, filed Oct. 28, 2010, the entire disclosures of which are incorporated by reference herein.The present invention relates to an unsolvated crystalline form, various solvates, and the HCl monohydrate salt of the antiviral compound 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (also known as 1263W94; maribavir; a compound of formula (I) below), pharmaceutical formulations comprising such crystalline form, solvates and the HCl monohydrate, and their use in therapy.5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (1263W94; maribavir) is a benzimidazole derivative useful in medical therapy. U.S. Pat. No. 6,077,832 discloses 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole and its use for the treatment or prophylaxis of viral infections such as those caused by herpes viruses. The compound as disclosed in U.S. Pat. No. 6,077,832 is an amorphous, non-crystalline material. ...

NEW INTERMEDIATES FOR THE VITAMIN A SYNTHESIS

The present invention relates to the compound of formula (I). The invention further relates to the compound of formula (II). The invention further relates to the synthesis of these compounds as well as to their use in organic synthesis, especially in the synthesis of vitamin A or p-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin. 5. Use of the compound of formula (I) in organic synthesis.6. Use according to claim 5 , wherein the vitamin A or β-carotene are produced (preferably vitamin A).7. Use of the compound of formula (II) in organic synthesis.8. Use according to claim 7 , wherein the vitamin A or β-carotene are produced (preferably vitamin A). The present invention relates to new compounds, to their synthesis and their use in organic synthesis, especially in the synthesis of vitamin A, Vitamin A acetate, or β-carotene and derivatives thereof, e.g. canthaxanthin, astaxanthin or zeaxanthin.Especially to be mentioned is that the new compounds are useful as intermediates (building blocks) in the synthesis of vitamin A or β-carotene, preferably in the synthesis of vitamin A (or vitamin A acetate).Vitamin A or its derivatives such as Vitamin acetateis an important ingredient for many applications. Vitamin A plays a role in a variety of functions throughout the (human) body, such as e.g. vision process, gene transcription, immune function, bone metabolism, haematopoiesis, skin and cellular health and antioxidant function.Due to the importance of vitamin A (and its derivatives) and the complexity of the synthesis thereof, there is always a need for improved processes of production.The goal of the present invention was to find easily accessible compounds, which can then be used in an improved synthesis of vitamin A or its derivates, or β-carotene, preferably vitamin A (acetate).The aim was achieved by the compounds and the synthesis as disclosed and described below.Three new compounds, which are useful intermediates, have been found:ρ- ...

PROCESS FOR THE PREPARATION OF POLYSANTOL-TYPE COMPOUNDS

The present invention relates to the field of organic synthesis and more specifically it concerns a novel compound of formula (I) which could be used as a novel intermediate in the process for the preparation of compound of formula (III). 4. The compound according to claim 1 , characterized in that the compound is an acetate or propionate of 3 claim 1 ,3-dimethyl-4-oxo-1-(2 claim 1 ,2 claim 1 ,3-trimethylcyclopent-3-en-1-yl)pentan-2-yl claim 1 , 1-(2 claim 1 ,2-dimethyl-3-methylenecyclohexyl)-3 claim 1 ,3-dimethyl-4-oxopentan-2-yl claim 1 , 3 claim 1 ,3-dimethyl-4-oxo-1-(2 claim 1 ,2 claim 1 ,3-trimethylcyclohex-3-en-1-yl)pentan-2-yl or 3-methyl-4-oxo-1-(2 claim 1 ,2 claim 1 ,3-trimethylcyclopent-3-en-1-yl)pentan-2-yl.6. The process according to claim 5 , characterized in that the step of elimination is a pyrolysis.7. The process according to claim 6 , characterized in that the pyrolysis is performed at a temperature between 400 and 600° C.9. The process according to claim 8 , characterized in that the process further comprises the step of preparing the compound of formula (V) by an aldol condensation between iso-propyl methyl ketone or propyl methyl ketone and RCHCHO wherein Rrepresents a Cbranched alkyl or a Calicyclic group optionally comprised an ether functional group.11. The process according to claim 5 , characterized in that the compound of formula (III) is selected from the group consisting of 3 claim 5 ,3-dimethyl-5-(2 claim 5 ,2 claim 5 ,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-one claim 5 , 3-methyl-5-(2 claim 5 ,2 claim 5 ,3-trimethylcyclopent-3-en-1-yl)pent-4-en-2-one claim 5 , 5-(2 claim 5 ,2-dimethyl-3-methylenecyclohexyl)-3 claim 5 ,3-dimethylpent-4-en-2-one and 3 claim 5 ,3-dimethyl-5-(2 claim 5 ,2 claim 5 ,3-trimethylcyclohex-3-en-1-yl)pent-4-en-2-one.13. The process according to claim 12 , characterized in that the process further comprises the step of preparing the compound of formula (VI) by the aldol condensation between α-campholenic ...

Odorants of the violet type

The present invention relates to the use as perfuming ingredient, in particular to confer odor notes of the violet, violet leaves type, of a compound of formula (I), wherein n represents 1 or 2, A represents CH 2 or CO; and R represents a C 1-4 alkyl or alkenyl group or a C 3 cycloalkyl group, or when A is a CH 2 group R may also represent a C 1-3 acyl group. Moreover, following what is mentioned herein, the present invention comprises the invention's compound as part of a perfuming composition or of a perfuming consumer product.

CARBONYLATION CATALYST AND PROCESS

A catalyst and process for the production of methyl acetate by contacting dimethyl ether and carbon monoxide in the presence of a catalyst which is a zeolite of micropore volume of 0.01 ml/g or less. 1. A catalyst for the carbonylation of dimethyl ether with carbon monoxide to produce methyl acetate wherein the catalyst comprises a zeolite of micropore volume of 0.01 ml/g or less and which zeolite contains at least one channel which is defined by an 8-member ring.2. The catalyst according to wherein the 8-member ring is interconnected with at least one channel defined by a ring with 10 or 12 members.3. The catalyst according to wherein the zeolite is selected from zeolites of framework type MOR claim 1 , FER claim 1 , CHA claim 1 , OFF claim 1 , MFS and GME.4. The catalyst according to wherein the zeolite is in an ion-exchanged form.5. The catalyst according to wherein the ion-exchanged form is an ammonium or hydrogen form.6. The catalyst according to wherein the zeolite has the framework type MOR and is a mordenite.7. The catalyst according to wherein the mordenite is in an ammonium form.8. The catalyst according to wherein the mordenite has the framework elements claim 6 , silicon claim 6 , aluminium and at least one of gallium claim 6 , boron and iron.9. The catalyst according to wherein the framework elements are silicon claim 8 , aluminium and gallium.10. The catalyst according to wherein the zeolite micropore volume is from 0.00 ml/g to 0.01 ml/g.11. The catalyst according to wherein the zeolite contains 4% or greater by weight of carbon.12. The catalyst according to wherein the zeolite contains 4% to 5% by weight of carbon.13. The catalyst according to in which the zeolite is an uncalcined zeolite.14. The catalyst according to wherein the zeolite is composited with a binder material.15. The catalyst according to wherein the zeolite is prepared from a synthesis mixture comprising a source of silica claim 1 , a source of alumina claim 1 , a source of alkali or ...

Process For The Preparation Of Hyperpolarized Carboxylate Compounds

The present invention relates to a process for the preparation of aqueous solutions of [1- 13 C]-hyperpolarized carboxylate containing molecules of diagnostic interest that comprises parahydrogenating with molecular para-hydrogen unsaturated alkenyl or alkynyl esters of the concerned 13 C-carboxylate molecules.

ESTER

Provided are a new ester that has a fresh and fruity fragrance note useful as a fragrance material, and a fragrance composition containing the ester. The ester is represented by the formula (I), and the fragrance composition contains the ester represented by the formula (I). 112-. (canceled)14: The ester according to claim 13 , wherein Ris methyl and Ris methyl.15: The ester according to claim 13 , wherein Ris ethyl and Ris hydrogen.16: The ester according to claim 13 , wherein Ris methyl or ethyl.17: A fragrance composition comprising the ester according to .18: The fragrance composition according to claim 17 , wherein a content of the ester in the fragrance composition is 0.01 to 99.9% by mass.19: The fragrance composition according to claim 17 , wherein a content of the ester in the fragrance composition is 0.1 to 15% by mass.20: A fragrance composition comprising at least two esters according to claim 13 , wherein claim 13 , in the first ester claim 13 , Ris methyl and Ris methyl claim 13 , and wherein claim 13 , in the second ester claim 13 , Ris ethyl and Ris hydrogen.21: The fragrance composition according to claim 20 , wherein a mass ratio of the first ester to the second ester (the first ester/the second ester) is 70/30 to 99.9/0.1.22: The fragrance composition according to claim 20 , wherein a mass ratio of the first ester to the second ester (the first ester/the second ester) is 80/20 to 99/1.23: The fragrance composition according to claim 17 , further comprising at least one member selected from the group consisting of an ester other than the ester represented by formula (I) claim 17 , an alcohol claim 17 , a carbonate claim 17 , an aldehyde claim 17 , a ketone claim 17 , an ether claim 17 , and a lactone.24: The fragrance composition according to claim 17 , further comprising an oil.25: The fragrance composition according to claim 17 , further comprising a surfactant.26: A method of imparting a fragrance to a fabric treatment composition claim 17 , ...

Preparation of acetate compounds via a ketene compound

The present invention relates to a method for preparing acetate compounds using ketene.

METHOD FOR PRODUCING (Z)-2-BENZOYLOXY-12-HEPTADECENE AND (2S,12Z)-2-HYDROXY-12-HEPTADECENE AND METHOD FOR PRODUCING (2S,12Z)-2-ACETOXY-12-HEPTADECENE

Provided are methods including a method for industrially producing (2S,12Z)-2-acetoxy-12-heptadecene, which is, for example, a sex pheromone of pistachio twig borer. The methods can include a production method comprising a step of reacting racemic (2RS,12Z)-2-hydroxy-12-heptadecene with vinyl benzoate in the presence of a lipase to obtain a mixture of optically active (2R,12Z)-2-benzoyloxy-12-heptadecene of Formula (R,Z-2) and optically active (2S,12Z)-2-hydroxy-12-heptadecene of Formula (S,Z-1), a step of heating the mixture to distill out the optically active (2S,12Z)-2-hydroxy-12-heptadecene (S,Z-1), and a step of acetylating the optically active (2S,12Z)-2-hydroxy-12-heptadecene (S,Z-1) to obtain optically active (2S,12Z)-2-acetoxy-12-heptadecene of Formula (S,Z-3). 1. (Z)-2-Benzoyloxy-12-heptadecene having a structure represented by Formula (RS,Z-2): This application is a divisional of U.S. patent application Ser. No. 14/837,683, filed Aug. 27, 2015, which claims priority from Japanese Patent Application No. 2014-187596, filed Sep. 16, 2014, the disclosure of each of which is incorporated by reference herein in its entirety.The present invention relates to methods for producing (Z)-2-benzoyloxy-12-heptadecene and optically active (2S,12Z)-2-hydroxy-12-heptadecene, and a method for producing optically active (2S,12Z)-2-acetoxy-12-heptadecene, which is, for example, a pheromone component of pistachio twig borer that is a major insect pest of pistachio trees.Pistachio twig borer (scientific name: Karmania pistaciella) is a significant insect pest of pistachio trees in Iran, Turkey and the like. Larvae of the insect damage pistachio trunks and cause serious problems such as reductions in crop yield and crop quality. At the present time, insecticides are used to control the pistachio twig borer but achieve an insufficient effect and may cause environmental and human health concerns. In such circumstances, there is a demand for the development of novel insect pest ...

PROCESS FOR THE PREPARATION OF INDANAMINE DERIVATIVES AND NEW SYNTHESIS INTERMEDIATES

Subject-matter of the invention is a process for the preparation of a key intermediate in the synthesis of indacaterol. Subject-matter of the invention are also new synthesis intermediates. Formula (I): 2. The process according to claim 1 , wherein Pr is selected from the group consisting of acetate claim 1 , trifluoroacetate and benzoate.3. The process according to claim 1 , wherein X is selected from the group consisting from methanesulfonate claim 1 , p-toluenesulfonate claim 1 , benzenesulfonate claim 1 , trifluoromethanesulfonate claim 1 , and a halogen atom.4. The process according to claim 1 , wherein steps (a) and (b) are carried out with an acyl halide and are performed in a one-pot reaction.5. The process according to claim 1 , wherein step (c) and step (e) are carried out by hydrogenation claim 1 , in the presence of a solvent and of a catalyst.6. The process according to claim 1 , wherein step (f) is not performed and in step (e) the ketone is reduced and at the same time the hydroxy group is deprotected claim 1 , to directly obtain the compound of formula (VIII).7. The process according to claim 1 , wherein in step (g) a mesyl or tosyl halide or a chlorinating agent is used.8. The process according to claim 1 , wherein in step (h) a compound of formula R—NHis used.9. The process according to claim 1 , wherein steps (b) and (d) are carried out at temperatures lower than zero and with dilutions of 4-6 volumes of solvent with respect to the starting compound.11. A compound of formula (IX) wherein X is selected from the group consisting of a halogen atom and a methanesulfonate claim 1 , p-toluenesulfonate claim 1 , benzenesulfonate claim 1 , and a trifluoromethanesulfonate group.12. (canceled)13. (canceled)15. The process according to claim 14 , wherein X is selected from the group consisting of a methanesulfonate claim 14 , p-toluenesulfonate claim 14 , benzenesulfonate claim 14 , trifluoromethanesulfonate group and a chlorine atom.16. The process ...

Method for Synthesising Cyclohexenones and the Use of Same in the Perfume Industry

The present invention concerns a method for synthesising cyclohexenone and cyclohexenol compounds having specific fragrances and remanence properties, said method consisting in condensing a ketone on an α-methylene-aldehyde in order to obtain, by means of a domino reaction, compounds of formula (I).

CRYSTALLINE PHASES OF 5,6-DICHLORO-2-(ISOPROPYLAMINO)-(1-BETA-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE

The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy. 1. A crystalline solvate of 5 ,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole , including a stoichiometric ratio of an organic solvent within a cavity of the crystal lattice , said solvent being selected from the group of: methanol , acetonitrile , ethyl acetate , diethylether , n-butylacetate , or 1-propanol , or mixtures thereof.2. Crystalline Form VI of 5 ,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole , wherein said compound has unit cell parameters a=b=9.2825 Å , c=41.602 Å , and P422 space group (recorded at 296 K). The present application is a continuation of U.S. patent application Ser. No. 13/282,510, filed Oct. 27, 2011, which claims the benefit of U.S. Provisional Patent Application No. 61/407,622, filed Oct. 28, 2010, the entire disclosures of which are incorporated by reference herein.The present invention relates to an unsolvated crystalline form, various solvates, and the HCl monohydrate salt of the antiviral compound 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (also known as 1263W94; maribavir; a compound of formula (I) below), pharmaceutical formulations comprising such crystalline form, solvates and the HCl monohydrate, and their use in therapy.5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (1263W94; maribavir) is a benzimidazole derivative useful in medical therapy. U.S. Pat. No. 6,077,832 discloses 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole and its use for the treatment or prophylaxis of viral infections such as those caused by herpes viruses. The compound as disclosed in U.S. Pat. No. 6,077,832 is an amorphous, non-crystalline material.The structure of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole ...

Carbonylation Process for the Production of Methyl Acetate

A process for the production of methyl acetate by carbonylating at a temperature of 250 to 350° C., in the presence of a zeolite catalyst, a feed comprising dimethyl ether, a gas comprising carbon monoxide and hydrogen at a molar ratio of hydrogen to carbon monoxide of at least 1, methyl acetate and one or more compounds containing a hydroxyl functional group. 1. A process for the carbonylation of dimethyl ether with carbon monoxide in the presence of a catalyst comprising a zeolite to produce a reaction product comprising methyl acetate wherein the process is carried out at a temperature of from 250 to 350° C. , the feed to the process comprises dimethyl ether , carbon monoxide , hydrogen and methyl acetate and the molar ratio of hydrogen to carbon monoxide in the feed is at least 1 and wherein the feed further comprises one or more compounds containing a hydroxyl functional group.2. A process according to wherein the zeolite is a templated zeolite.3. A process according to wherein the feed comprises the hydroxyl compound(s) in a total amount of up to 1 mol % based on the total gaseous feed to the process.4. A process according to wherein the feed comprises the hydroxyl compound(s) in a total amount of 0.01 to 0.5 mol % based on the total gaseous feed to the process.5. A process according to claim 1 , wherein the feed comprises methyl acetate and the hydroxyl compound(s) at a molar ratio of methyl acetate to hydroxyl compound(s) in the range 500:1 to 0.5:1.6. A process according to claim 1 , wherein the feed comprises the one or more hydroxyl compound(s) selected from aliphatic alcohols claim 1 , aliphatic carboxylic acids claim 1 , water and mixtures thereof.7. A process according to wherein the hydroxyl compound is a C-Caliphatic alcohol.8. A process according to wherein the hydroxyl compound is a C-Caliphatic carboxylic acid.9. A process according to wherein the hydroxyl compound is selected from one or more of water claim 6 , acetic acid and methanol.10. A ...

Method for producing and purifying 2,3,3,3-tetrafluoro-1-propene

The present invention concerns a method for producing for producing and purifying 2,3,3,3-tetrafluoro-1-propene (1234yf) from a first composition comprising 2,3,3,3-tetrafluoro-1-propene and chloromethane (40), said method comprising the steps of: (a) bringing said first composition into contact with at least one organic extractant in order to form a second composition; (b) extractive distillation of said second composition in order to form (i) a third composition comprising said organic extractant and chloromethane (40); and (ii) a stream comprising 2,3,3,3-tetrafluoro-1-propene (1234yf); (c) recovering and separating said third composition, preferably by distillation, in order to form a stream comprising said organic extractant and a stream comprising chloromethane (40).

RADIATION-SENSITIVE RESIN COMPOSITION, RESIST PATTERN-FORMING METHOD, ACID DIFFUSION CONTROL AGENT, CARBOXYLIC ACID SALT AND CARBOXYLIC ACID

A radiation-sensitive resin composition contains: a polymer having an acid-labile group, a radiation-sensitive acid generator, a compound represented by the following formula (1), and a solvent. In the formula (1), X represents an oxygen atom or a sulfur atom; Rrepresents a hydrogen atom or a monovalent organic group having 1 to 20 carbon atoms; Rto Reach independently represent a hydrogen atom or a monovalent organic group having 1 to 20 carbon atoms, and optionally two or more of Rto Rtaken together represent an alicyclic structure having 3 to 20 ring atoms or an aliphatic heterocyclic structure having 3 to 20 ring atoms together with the carbon atom to which the two or more of Rto Rbond; Z represents a cation having a valency of n; and n is an integer of 1 to 3. 2. The radiation-sensitive resin composition according to claim 1 , wherein Rin the formula (1) represents a hydrogen atom.3. The radiation-sensitive resin composition according to claim 1 , wherein Rand Rin the formula (1) taken together represent an alicyclic structure having 3 to 20 ring atoms or an aliphatic heterocyclic structure having 3 to 20 ring atoms together with the carbon atom to which Rand Rbond.4. The radiation-sensitive resin composition according to claim 1 , wherein Rand Rin the formula (1) each independently represent a substituted or unsubstituted hydrocarbon group claim 1 , a group comprising an aliphatic heterocyclic structure claim 1 , or a hydrogen atom.5. The radiation-sensitive resin composition according to claim 1 , wherein Rand Rin the formula (1) each independently represent a hydrogen atom.6. The radiation-sensitive resin composition according to claim 1 , wherein the radiation-sensitive acid generator generates sulfonic acid upon irradiation with a radioactive ray.7. A resist pattern-forming method comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'applying the radiation-sensitive resin composition according to directly or indirectly on one face of a substrate to ...

Process for the production of vinyl esters of organic acids

Acetylene is reacted with organic carboxylic acids to produce vinyl esters, the acetylene being first contacted while under non-explosive conditions with a liquid volatile organic compound maintained at a predetermined temperature, the acetylene being thereby saturated with the vapour of the organic liquid; the ratio of acetylene to vapour is such that the mixture is non-explosive when introduced into the reaction zone (the temperature being high enough to prevent condensation of the vapour), although the temperature and pressure therein are such that the acetylene would normally be explosive. The volatile organic liquid may be the acid used in the reaction, the ester produced, or other compounds such as hydrocarbons, heterocyclic compounds, esters or ethers, suitable compounds being mentioned. A further inert diluent of this type may be used for the reaction if desired. Zinc or cadmium salts of organic acids are used as catalysts, these being formed in situ if desired. Many suitable acids are specified, aliphatic, aromatic, hydroaromatic and heterocyclic; polybasic acids or acid esters, cyclic hydroxy acids and phenyl-glycine may also be used, as well as mixtures of acids or acid esters such as those obtained from resins, from the saponification of fats or oils or from the partial oxidation of petroleum fractions, e.g. paraffin wax. When hydroxy-acids are used, the presence of zinc salts as catalysts favours the production of esters rather than ethers, the latter being formed when using an alkaline catalyst as in Specification 641,436. The vinyl esters produced may be recovered and purified by known methods, and polymerization inhibitors may be added. The esters may be polymerized by the usual methods. Examples show the reaction of acetylene with acetic, valeric and oleic acids. Specifications 182,112, 285,095, 288,707, [all in Class 2 (iii)], 378,873, 572,910, 578,405, 581,501 and U.S.A. Specification 2,066,075 also are referred to.

CRYSTALLINE PHASES OF 5,6-DICHLORO-2-(ISOPROPYLAMINO)-(1 BETA-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE

The invention relates to novel crystalline phases of 5,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole (Maribavir), pharmaceutical compositions thereof and their use in medical therapy. 12-. (canceled)3. A crystalline form of 5 ,6-dichloro-2-(isopropylamino)-1-(β-L-ribofuranosyl)-1H-benzimidazole , wherein the crystal form is a hydrochloride monohydrate salt.4. The crystalline form of claim 3 , wherein the crystalline form has unit cell parameters a=22.25 Å claim 3 , b=22.25 Å claim 3 , c=8.016 Å claim 3 , and P422 space group (recorded at 293 K).5. The crystalline form of claim 3 , wherein the crystalline form is characterized by an X-ray powder diffraction pattern comprising peaks at 5.619±0.1° and 7.996±0.1° 2-theta.6. The crystalline form of claim 3 , wherein the crystalline form is characterized by an X-ray powder diffraction pattern comprising peaks at 5.619±0.1° claim 3 , 7.996±0.1° claim 3 , 8.921±0.1° claim 3 , 16.881±0.1° claim 3 , and 22.613±0.1° 2-theta.7. The crystalline form of claim 3 , wherein the crystalline form is characterized by an X-ray powder diffraction pattern comprising peaks at 5.619±0.1° claim 3 , 7.996±0.1° claim 3 , 8.921±0.1° claim 3 , 14.375±0.1° claim 3 , 16.881±0.1° claim 3 , 19.857±0.1° claim 3 , 20.997±0.1° claim 3 , 22.613±0.1° claim 3 , 22.842±0.1° claim 3 , and 25.298±0.1° 2-theta.8. The crystalline form of claim 3 , wherein the crystalline form is characterized by an X-ray powder diffraction pattern comprising peaks at 5.619±0.1° claim 3 , 7.996±0.1° claim 3 , 8.921±0.1° claim 3 , 11.280±0.1° claim 3 , 11.734±0.1° claim 3 , 14.375±0.1° claim 3 , 16.881±0.1° claim 3 , 19.857±0.1° claim 3 , 20.997±0.1° claim 3 , 21.506±0.1° claim 3 , 22.613±0.1° claim 3 , 22.842±0.1° claim 3 , 23.989±0.1° claim 3 , 24.948±0.1° claim 3 , and 25.298±0.1° 2-theta.9. The crystalline form of claim 5 , wherein the X-ray powder diffraction pattern is collected using a TTK450 chamber.10. The crystalline form of claim 5 , wherein the ...

Esterifying acetic acid to produce ester feed for hydrogenolysis

Disclosed herein are processes for alcohol production by reducing an esterification product, such as ethyl acetate. The processes comprise esterifying an excess molar ratio of acetic acid with an alcohol, such as ethanol, to produce the esterification product. The esterification product is reduced with hydrogen in the presence of a catalyst to obtain a crude reaction mixture comprising the alcohol, in particular ethanol, which may be separated from the crude reaction mixture.

Hydrogenolysis of ethyl acetate in alcohol separation processes

Recovery of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid and by reacting a portion of the crude ethanol product or one or more derivative streams containing ethyl acetate obtained therefrom in the presence of hydrogen, via hydrogenolyzis. The one or more derivative streams comprise ethyl acetate that are reacted via hydrogenolyzis to form additional ethanol that may be directly or indirectly fed to the separation zone or the hydrogenation reactor.

Liquid esterification for the production of alcohols

Purifying and/or recovery of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid. Separation and purification processes of crude ethanol mixture are employed to allow recovery of ethanol and remove impurities. In addition, the process involves returning acetaldehyde separated from the crude ethanol product to the reactor.

Process to recover alcohol with secondary reactors for hydrolysis of acetal

A process for recovering ethanol obtained from the hydrogenation of acetic acid. The crude ethanol product is separated in a column to produce a distillate stream comprising acetaldehyde and ethyl acetate and a residue stream comprising ethanol, acetic acid and water. Acetal byproduct can be reduced or removed through configurations of hydrolysis secondary reactors. The ethanol product is recovered from the residue stream.

Process to recover alcohol with secondary reactors for esterification of acid

A process for recovering ethanol obtained from the hydrogenation of acetic acid. The crude ethanol product is separated in a column to produce a distillate stream comprising acetaldehyde and ethyl acetate and a residue stream comprising ethanol, acetic acid, ethyl acetate and water. Unreacted acetic acid can be reduced or removed through configurations of esterification secondary reactors. The ethanol product is recovered from the residue stream.

Vapor esterification method to produce ester feed for hydrogenolysis

Disclosed herein are processes for alcohol production by reducing an esterification product, such as ethyl acetate. The processes comprise esterifying, in the vapor phase, acetic acid and an alcohol such as ethanol to produce the esterification product. The esterification product is reduced with hydrogen in the presence of a catalyst to obtain a crude reaction mixture comprising the alcohol, in particular ethanol, which may be separated from the crude reaction mixture.

Liquid esterification method to produce ester feed for hydrogenolysis

Disclosed herein are processes for alcohol production by reducing an esterification product, such as ethyl acetate. The processes comprise esterifying, in the liquid phase, acetic acid and an alcohol such as ethanol to produce an esterification product. The esterification product is reduced with hydrogen in the presence of a catalyst to obtain a crude reaction mixture comprising the alcohol, in particular ethanol, which may be separated from the crude reaction mixture.

Esterification process using extractive separation to produce feed for hydrogenolysis

Disclosed herein are processes for alcohol production by reducing an esterification product, such as ethyl acetate. The processes comprise esterifying acetic acid and an alcohol such as ethanol to produce an esterification product. The esterification product may be recovered using an extractive separation. The esterification product is reduced with hydrogen in the presence of a catalyst to obtain a crude reaction mixture comprising the alcohol, in particular ethanol, which may be separated from the crude reaction mixture.

Processo per la produzione di acetato di etile per omologazione di acetato di metile

DIMETHYL CARBONILATION PROCESS

Process to recover alcohol with reduced water from overhead of acid column

A process for recovering ethanol obtained from the hydrogenation of acetic acid. The crude ethanol product is separated in a column to produce a distillate stream comprising acetaldehyde and ethyl acetate and a residue stream comprising ethanol, acetic acid, ethyl acetate and water. The ethanol product is recovered from the residue stream.

Reduced energy alcohol separation process having controlled pressure

The present invention is directed to processes for the recovery of ethanol from a crude ethanol product obtained from the hydrogenation of acetic acid using a low energy process. The crude ethanol product is separated in one or more columns. At least one of the columns is operated at a controlled pressure to enhance separation of ethanol and organics. In one embodiment, there are at least two columns that operate at controlled pressures.

Process to recover alcohol with reduced water from overhead of acid column

A process for recovering ethanol obtained from the hydrogenation of acetic acid. The crude ethanol product is separated in a column to produce a distillate stream comprising acetaldehyde and ethyl acetate and a residue stream comprising ethanol, acetic acid, ethyl acetate and water. The ethanol product is recovered from the residue stream.

Process for carbonylation of dimethyl ether

FIELD: chemistry. SUBSTANCE: invention relates to a process for the preparation of methyl acetate by carbonylation of dimethyl ether with carbon monoxide in the presence of hydrogen and a zeolite catalyst, in which at the first step carbonylation is carried out at a molar ratio of the amount of carbon monoxide to the amount of hydrogen of at least 1, and at the second and next step, carbonylation is carried out at a molar ratio of the amount of hydrogen to the amount of carbon monoxide greater than 1. EFFECT: invention also relates to a method for improving the performance of a zeolite catalyst in the preparation of methyl acetate by carbonylation of dimethyl ether with carbon monoxide in the presence of hydrogen and said catalyst. 30 cl, 6 ex, 8 tbl, 8 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 656 599 C2 (51) МПК C07C 67/37 (2006.01) C07C 69/14 (2006.01) B01J 29/18 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 67/37 (2006.01); C07C 69/14 (2006.01); B01J 29/18 (2006.01) (21)(22) Заявка: 2015142611, 06.03.2014 (24) Дата начала отсчета срока действия патента: Дата регистрации: (73) Патентообладатель(и): БП КЕМИКЭЛЗ ЛИМИТЕД (GB) 06.06.2018 (56) Список документов, цитированных в отчете о поиске: RU 2411232 C2, 10.02.2011. US 08.03.2013 EP 13158471.6 (43) Дата публикации заявки: 13.04.2017 Бюл. № 11 20100121099 A, 13.05.2010. EP 1985606 A1,29.10.2008. RU 2457030 C2, 27.07.2012. (45) Опубликовано: 06.06.2018 Бюл. № 16 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 08.10.2015 2 6 5 6 5 9 9 Приоритет(ы): (30) Конвенционный приоритет: R U 06.03.2014 (72) Автор(ы): ДИТЗЕЛ Эверт Джан (GB), ГАГЕА Богдан Костин (GB), САНЛИ Джон Гленн (GB) EP 2014/054397 (06.03.2014) C 2 C 2 (86) Заявка PCT: (87) Публикация заявки PCT: R U 2 6 5 6 5 9 9 WO 2014/135663 (12.09.2014) Адрес для переписки: 105082, Москва, Спартаковский пер., 2, стр. 1, секция 1, этаж 3, ЕВРОМАРКПАТ (54) СПОСОБ КАРБОНИЛИРОВАНИЯ ...

Method for carbonylation of dimethyl ether

FIELD: chemistry. SUBSTANCE: invention relates to catalysts for producing methyl acetate and a method of producing methyl acetate. Described is a method of producing methyl acetate, involving carbonylation of dimethyl ether-based material with carbon monoxide with almost no water in the presence of a mordenite catalyst in which at least one of the following elements is introduced using an ion exchange or some other method: silver and copper, and in which platinum is also introduced into the mordenite via an ion exchange or some other method in amount of 0.05-10 mol % with respect to aluminium. Described is a catalyst for producing methyl acetate via carbonylation of dimethyl ether-based material with carbon monoxide in virtually anhydrous conditions, which is prepared via simultaneous ion exchange or saturation of the ammonium or hydrogen form of mordenite with platinum and at least one of the metals - silver and copper, drying and/or calcination of the mordenite which has been saturated or subjected to ion exchange, wherein the catalyst contains platinum in amount of 0.05-10 mol % with respect to aluminium and a catalyst prepared via ion exchange or saturation of the ammonium or hydrogen form of mordenite with at least one of the metals - silver and copper, drying and/or calcination of the mordenite which has been saturated or subjected to ion exchange to obtain copper- and/or silver-containing mordenite, followed by ion exchange or saturation of the copper- and/or silver-containing mordenite with platinum, wherein the catalyst contains platinum in amount of 0.05-10 mol % with respect to aluminium. EFFECT: high catalytic activity. 15 cl, 1 tbl, 2 dwg, 2 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) 2 457 030 (13) C2 (51) МПК B01J B01J C07C C07C 29/22 (2006.01) 29/24 (2006.01) 69/14 (2006.01) 67/37 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2009143553/04, 23.04.2008 (24) Дата начала отсчета срока ...

Method for combined production of acetic acid and dimethyl ether

FIELD: chemistry. SUBSTANCE: invention relates to a method for combined production of acetic acid and dimethyl ether by dehydration-hydrolysis of a feed mixture of methanol and methyl acetate in the presence of at least one catalyst to obtain a crude reaction product containing acetic acid and dimethyl ether, in which the raw material for said combined production method contains methanol, methyl acetate and dimethyl ether, in which dimethyl ether is present in the raw material in a total amount of 25 mol. % or less in terms of all raw materials. EFFECT: disclosed is a method for combined production of acetic acid and dimethyl ether. 19 cl, 4 dwg, 4 tbl, 4 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) (19) RU (51) МПК C07C 51/09 C07C 41/09 C07C 67/37 C07C 43/04 C07C 53/08 C07C 69/14 C07C 41/16 (11) (13) 2 708 261 C2 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 51/09 (2019.08); C07C 41/09 (2019.08); C07C 67/37 (2019.08); C07C 43/04 (2019.08); C07C 53/08 (2019.08); C07C 69/14 (2019.08); C07C 41/16 (2019.08) (21)(22) Заявка: 2016146790, 12.06.2015 12.06.2015 (73) Патентообладатель(и): БП КЕМИКЭЛЗ ЛИМИТЕД (GB) Дата регистрации: 05.12.2019 Приоритет(ы): (30) Конвенционный приоритет: 20.06.2014 EP 14173349.3 (43) Дата публикации заявки: 29.05.2018 Бюл. № 16 (45) Опубликовано: 05.12.2019 Бюл. № 34 (86) Заявка PCT: EP 2015/063148 (12.06.2015) C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 29.11.2016 (87) Публикация заявки PCT: 2 7 0 8 2 6 1 WO 2015/193183 (23.12.2015) R U 2 7 0 8 2 6 1 (56) Список документов, цитированных в отчете о поиске: WO 2011/027105 A1, 10.03.2011. WO 2013124404 A1, 29.08.2013. WO 2013/124423 A1, 29.08.2013. EA 0693 B1, 28.02.2000. R U (24) Дата начала отсчета срока действия патента: (72) Автор(ы): БРИСТОУ Тимоти Криспин (GB) Адрес для переписки: 105082, Москва, Спартаковский пер., 2, стр. 1, секция 1, этаж 3, ЕВРОМАРКПАТ ( ...

Способ очистки смесей метилацетата

Предложен способ удаления ацетальдегида из смеси метилацетата, диметилового эфира и ацетальдегида, включающий:(i) загрузку смеси метилацетата, ацетальдегида и диметилового эфира в дистилляционную колонну; (ii) дистилляцию смеси с получением отводимого с верха колонны потока, обедненного ацетальдегидом по сравнению с загруженной смесью, основного потока, обедненного ацетальдегидом по сравнению с загруженной смесью, и бокового потока, обогащенного ацетальдегидом по сравнению с загруженной смесью; (iii) отбор из колонны бокового потока, обогащенного ацетальдегидом, в положении выше положения загрузки смеси, загружаемой в колонну; и в котором смесь, загружаемую в дистилляционную колонну, получают с помощью одного или большего количества способов карбонилирования диметилового эфира монооксидом углерода в присутствии цеолитного катализатора карбонилирования. Также предложен способ совместного получения уксусной кислоты и диметилового эфира. Технический результат – обеспечение содержаний ацетальдегида и метилформиата, приемлемых для последующего применения в способах совместного получения уксусной кислоты и диметилового эфира из содержащего метилформиат и метанол сырья. 2 н. и 17 з.п. ф-лы, 4 ил., 7 табл., 5 пр. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (51) МПК C07C 27/02 C07C 43/04 C07C 41/09 C07C 51/09 C07C 53/08 C07C 47/09 (11) (13) 2 680 101 C2 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 41/09 (2018.08); C07C 43/04 (2018.08); C07C 51/09 (2018.08); C07C 47/06 (2018.08); C07C 27/00 (2018.08); C07C 53/08 (2018.08) (21)(22) Заявка: 2016146554, 12.06.2015 12.06.2015 (73) Патентообладатель(и): БП КЕМИКЭЛЗ ЛИМИТЕД (GB) Дата регистрации: 15.02.2019 Приоритет(ы): (30) Конвенционный приоритет: 2470007 C2, 20.12.2012. RU 2065850 C1, 27.08.1996. WO 2013124404 A1, 29.08.2013. WO 2011027105 A1, 10.03.2010. 20.06.2014 EP 14173354.3 (43) Дата публикации заявки: 30.05.2018 Бюл. № ...

Способ карбонилирования для получения метилацетата

Изобретение относится к способу карбонилирования диметилового эфира монооксидом углерода в присутствии катализатора, содержащего цеолит, для получения продукта реакции, содержащего метилацетат, где способ проводят при температуре, равной от 250 до 350°C, сырье для проведения способа содержит диметиловый эфир, монооксид углерода, водород, метилацетат, и одно или большее количество соединений, содержащих функциональную гидроксигруппу, выбирают из воды, алифатического C 1 -C 4 -спирта и алифатической C 1 -C 4 -карбоновой кислоты, и отношение количества молей водорода к количеству молей монооксида углерода в сырье равно не менее 1, и отношение количества молей метилацетата к количеству молей одного или большего количества соединений, содержащих функциональную гидроксигруппу, находится в диапазоне от 500:1 до 0,5:1. Изобретение также относится к способу поддержания или уменьшения скорости дезактивации катализатора в способе карбонилирования диметилового эфира монооксидом углерода в присутствии катализатора и к применению одного или большего количества соединений, содержащих функциональную гидроксигруппу, для поддержания или уменьшения скорости дезактивации катализатора в способе карбонилирования диметилового эфира монооксидом углерода в присутствии катализатора, содержащего цеолит, для получения продукта реакции, содержащего метилацетат, где способ проводят при температуре, равной от 250 до 350°C, использующееся в способе сырье содержит диметиловый эфир, монооксид углерода, водород и метилацетат, и отношение количества молей водорода к количеству молей монооксида углерода в сырье, равно не менее 1, и где сырье дополнительно включает одно или большее количество соединений, содержащих функциональную гидроксигруппу, выбраных из воды, алифатического C 1 -C 4 -спирта и алифатической C 1 -C 4 -карбоновой кислоты. 3 н. и 17 з.п. ф-лы, 9 табл., 8 пр. РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 739 320 C2 (51) МПК C07C 67/37 (2006.01) C07C 69/14 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ...

Carbonylation method

FIELD: chemistry. SUBSTANCE: invention relates to a process for the preparation of methyl acetate, which comprises carbonylating dimethyl ether with carbon monoxide in the presence of hydrogen and a zeolite catalyst, wherein the process is carried out at a molar ratio of the amount of hydrogen to the amount of carbon monoxide of at least 1, and the catalyst is calcined at a temperature of about 375 to about 475°C. EFFECT: invention also relates to a method for improving the performance of a zeolite catalyst in the preparation of methyl acetate by carbonylation of dimethyl ether with carbon monoxide in the presence of hydrogen and a zeolite catalyst. 27 cl, 4 dwg, 5 tbl, 4 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 658 005 C2 (51) МПК C07C 67/37 (2006.01) C07C 69/14 (2006.01) B01J 29/18 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК C07C 67/37 (2006.01); C07C 69/14 (2006.01); B01J 29/18 (2006.01) (21)(22) Заявка: 2015142612, 06.03.2014 (24) Дата начала отсчета срока действия патента: Дата регистрации: 19.06.2018 R U 06.03.2014 (72) Автор(ы): ДИТЗЕЛ Эверт Джан (GB), ГАГЕА Богдан Костин (GB), ХЕЙЗЕЛ Николас Джон (GB), САНЛИ Джон Гленн (GB) (73) Патентообладатель(и): БП КЕМИКЭЛЗ ЛИМИТЕД (GB) (56) Список документов, цитированных в отчете о поиске: EP 1985606 A1, 29.10.2008. WO 08.03.2013 EP 13158468.2 (43) Дата публикации заявки: 13.04.2017 Бюл. № 11 2008073096 A1, 19.06.2008. RU 2457030 C2, 27.07.2012. (45) Опубликовано: 19.06.2018 Бюл. № 17 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 08.10.2015 2 6 5 8 0 0 5 Приоритет(ы): (30) Конвенционный приоритет: EP 2014/054392 (06.03.2014) C 2 C 2 (86) Заявка PCT: (87) Публикация заявки PCT: R U 2 6 5 8 0 0 5 WO 2014/135660 (12.09.2014) Адрес для переписки: 105082, Москва, Спартаковский пер., 2, стр. 1, секция 1, этаж 3, ЕВРОМАРКПАТ (54) СПОСОБ КАРБОНИЛИРОВАНИЯ (57) Реферат: Изобретение относится к способу получения метилацетата, который включает ...

Способ совместного получения уксусной кислоты и диметилового эфира

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2016 146 790 A (51) МПК C07C 51/09 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2016146790, 12.06.2015 (71) Заявитель(и): БП КЕМИКЭЛЗ ЛИМИТЕД (GB) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): БРИСТОУ Тимоти Криспин (GB) 20.06.2014 EP 14173349.3 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 29.11.2016 R U (43) Дата публикации заявки: 29.05.2018 Бюл. № 16 (86) Заявка PCT: (87) Публикация заявки PCT: WO 2015/193183 (23.12.2015) R U (54) СПОСОБ СОВМЕСТНОГО ПОЛУЧЕНИЯ УКСУСНОЙ КИСЛОТЫ И ДИМЕТИЛОВОГО ЭФИРА (57) Формула изобретения 1. Способ совместного получения уксусной кислоты и диметилового эфира с помощью дегидратации-гидролиза загружаемой смеси метанола и метилацетата в присутствии по меньшей мере одного катализатора с получением неочищенного продукта реакции, содержащего уксусную кислоту и диметиловый эфир, в котором сырье для указанного способа совместного получения, содержащее метанол и метилацетат, содержит диметиловый эфир в полном количестве, равном 25 мол. % или менее в пересчете на все сырье. 2. Способ по п. 1, в котором сырье для способа совместного получения содержит метилацетат в количестве, равном от 10 до 95 мол. %, диметиловый эфир в количестве, равном от 0,1 до 25 мол. %, метанол в количестве, равном от 5 до 20 мол. %, и загрязняющие вещества в полном количестве, равном от 0 до менее 1 мол. %. 3. Способ по п. 2, в котором загрязняющие вещества выбраны из группы, включающей один или большее количество следующих: ацетальдегид, ацетон и метилформиат. 4. Способ по п. 2, в котором сырье содержит диметиловый эфир в количестве, равном от 0,1 до 5 мол. %. 5. Способ по п. 2, в котором сырье дополнительно содержит воду. 6. Способ по п. 1, в котором метилацетатное сырье содержит диметиловый эфир и получено из потока неочищенного метилацетата, полученного в способах Стр.: 1 A 2 0 1 6 1 4 6 7 9 0 A Адрес для переписки: 105082, Москва, ...

Объединенный способ получения метилацетата и метанола из синтез-газа и диметилового эфира

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2015 129 643 A (51) МПК C07C 67/37 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2015129643, 19.12.2013 (71) Заявитель(и): БП КЕМИКЭЛЗ ЛИМИТЕД (GB) Приоритет(ы): (30) Конвенционный приоритет: 21.12.2012 EP 12199092.3 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 21.07.2015 R U (43) Дата публикации заявки: 30.01.2017 Бюл. № 04 (72) Автор(ы): БЕККЕР Эдо Йоханн (GB), БРИСТОУ Тимоти Криспин (GB) (86) Заявка PCT: (87) Публикация заявки PCT: WO 2014/096246 (26.06.2014) R U (54) ОБЪЕДИНЕННЫЙ СПОСОБ ПОЛУЧЕНИЯ МЕТИЛАЦЕТАТА И МЕТАНОЛА ИЗ СИНТЕЗГАЗА И ДИМЕТИЛОВОГО ЭФИРА (57) Формула изобретения 1. Объединенный способ получения метилацетата и метанола, включающий следующие стадии: (I) подача синтез-газа и диметилового эфира в реакционную зону карбонилирования и взаимодействие в ней диметилового эфира и синтез-газа в присутствии катализатора карбонилирования с образованием газообразного продукта реакции карбонилирования, включающего метилацетат и обогащенный водородом синтез-газ, (II) отведение продукта реакции карбонилирования из реакционной зоны карбонилирования и извлечение по крайней мере из части продукта карбонилирования жидкого, обогащенного метилацетатом потока и потока синтез-газа, и (III) подача по крайней мере части потока синтез-газа, извлеченного из продукта реакции карбонилирования, в реакционную зону синтеза метанола и контактирование в ней этого потока с катализатором синтеза метанола, с образованием продукта синтеза метанола, включающего метанол и непрореагировавший синтез-газ. 2. Способ по п. 1, дополнительно включающий следующие стадии: (IV) отведение продукта синтеза метанола из зоны синтеза метанола и извлечение из него жидкого, обогащенного метанолом потока и потока синтез-газа, и (V) возвращение по крайней мере части потока синтез-газа, извлеченного из продукта синтеза метанола, через рециркуляционную ситему в зону синтеза метанола. 3. ...

Patent RU2016146554A3

ВУ” 2016146554” АЗ Дата публикации: 17.12.2018 Форма № 18 ИЗИМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение ж 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2016146554/04(074/71Т) 12.06.2015 РСТ/ЕР2015/063147 12.06.2015 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 14173354.3 20.06.2014 ЕР* Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) СПОСОБ ОЧИСТКИ СМЕСЕЙ МЕТИЛАЦЕТАТА Заявитель: Б] КЕМИКЭЛЗ ЛИМИТЕД, ОВ 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты (см. Примечания) [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) С07С 27/02 (2006.01) С07С 41/09 (2006.01) С07С 53/08 (2006.01) С07С 43/04 (2006.01) С07С 51/09 (2006.01) С07С 47/09 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) С07С 27/02, С07С 41/09, С07С 53/08, С07С 43/04, С07С 51/09, С07С 47/09 5.2 Другая проверенная документация в той мере, в какой она включена в поисковые подборки: 5.3 Электронные базы данных, использованные при поиске (название базы, и если, возможно, поисковые термины): ЕАРАТЬУ, Езрасепе, боозе, ]-Р]а Рав Рабзеагсь, КОРТО, ИЗРТО 6. ДОКУМЕНТЫ, ОТНОСЯЩИЕСЯ К ПРЕДМЕТУ ПОИСКА Кате- ...

Plasticizers for resin compositions and resin compositions including the same

The present invention is a plasticizer of a resin composition comprising at least one selected from a polyvinyl chloride resin, a polyurethane resin, an epoxy resin, a polycarbonate resin or a biodegradable resin, and is excellent in mechanical properties such as tensile strength, elongation, hardness, A plasticizer for a resin composition excellent in transparency, heat resistance, cold resistance and durability without causing bleeding due to excellent flexibility at low temperatures, good compatibility with resins, and a resin composition containing the plasticizer are provided do.

用于提纯乙酸甲酯混合物的方法

用于从乙酸甲酯、二甲醚和乙醛的混合物中移除乙醛的方法，其包括蒸馏源自在沸石催化剂的存在下使二甲醚羰基化的混合物以生成与进料混合物相比贫乙醛的塔顶料流、与进料混合物相比贫乙醛的塔底料流和与进料混合物相比富乙醛的侧取料流，并将富乙醛的侧取料流在进料混合物送往塔的进料位点上方的位点处从塔中取出。经提纯的混合物可用作乙酸和二甲醚的联合生产方法的原料。

Method for producing beta-acetoxypivalaldehyde

Carbonylation catalyst and method

FIELD: chemistry. SUBSTANCE: invention relates to a carbonylation method for producing methyl acetate which, upon start-up, involves reacting dimethyl ether with carbon monoxide under carbonylation reaction conditions at temperature equal to 200 to 350 °C, in the presence of a catalyst which contains a zeolite having a micropore volume equal to 0.00–0.01 ml/g, and said zeolite contains at least one channel which is formed by 8-member ring. EFFECT: technical result is the development of a carbonylation method for producing methyl acetate, in which by eliminating an induction period by using a certain zeolite catalyst or shorter duration of induction period, which leads to improved selectivity of acetylated products when starting the carbonylation method. 28 cl, 2 tbl, 2 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (51) МПК C07C 67/37 C07C 53/08 C07C 51/09 C07C 69/14 B01J 35/10 B01J 29/06 ФЕДЕРАЛЬНАЯ СЛУЖБА B01J 29/18 ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ B01J 29/24 B01J 29/65 B01J 29/70 (12) (11) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (13) 2 696 266 B01J 29/87 B01J 37/00 B01J 37/30 C01B 39/02 C01B 39/26 C01B 39/48 C2 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК (21)(22) Заявка: 2015142614, 06.03.2014 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): БП КЕМИКЭЛЗ ЛИМИТЕД (GB) Дата регистрации: 01.08.2019 Приоритет(ы): (30) Конвенционный приоритет: 08.03.2013 EP 13158470.8 (43) Дата публикации заявки: 13.04.2017 Бюл. № 11 (56) Список документов, цитированных в отчете о поиске: US 2007/0238897 A1, 11.10.2007. EP 1985607 A1, 29.10.2008. WO 2005/105720 A1, 10.11.2005. WO 2010/130973 A2, 18.11.2010. EP 2251083 A1, 17.11.2010. RU 2458909 C2, 20.08.2012. EA 201001010 A1, 28.02.2011. EP 1101735 A1, 23.05.2001. (45) Опубликовано: 01.08.2019 Бюл. № 22 C 2 C 2 (72) Автор(ы): САНЛИ Джон Гленн (GB) (85) Дата начала рассмотрения заявки PCT на национальной фазе ...

Ionic liquid compound

본 발명은 화학식 (I)의 이온 액체 화합물과 알킬화 및 아릴화, 아실화, Diels Alder, 올리고머화화 같은 반응에서 이의 응용을 제공한다. [(NR 1 R 2 R 3 ) i M 1 ] n+ [(M 2 Y k ) L X j ] n- 화학식 I 본 발명은 화학식 (I)의 이온 액체 화합물 제조 공정을 제공하며 이는 화학식 NR 1 R 2 R 3 의 아민과 화학식 M 1 X j 의 금속염을 혼합하는 공정과 이온 염 복합체와 화학식 M 1 X j 의 금속염을 혼합하여 이온 액체 화합물을 수득하는 공정에 의하여 화학식 [(NR 1 R 2 R 3 ) i M 1 ] n+ [X j ] n 의 이온 염 복합체를 제조하는 공정을 동반한다. The present invention provides its application in reactions such as alkylation and arylation, acylation, Diels Alder, oligomerization with ionic liquid compounds of formula (I). [(NR 1 R 2 R 3 ) i M 1 ] n + [(M 2 Y k ) L X j ] n- Formula I The present invention provides a process for preparing an ionic liquid compound of formula (I), which comprises mixing an amine of formula NR 1 R 2 R 3 with a metal salt of formula M 1 X j and an ionic salt complex with a metal salt of formula M 1 X j It is accompanied by a step of preparing an ionic salt complex of the formula [(NR 1 R 2 R 3 ) i M 1 ] n + [X j ] n by the step of mixing to obtain an ionic liquid compound.

Novel ester compound having alicyclic structure and process for producing the same

Biaromatic acetylene compounds having adamantyl group, pharmaceutical and cosmetic composition on their base

Изобретение относится к новым би-ароматическим соединениям ацетиленов с группой адамантила, которые имеют общую формулу и к использованию этих последних в фармацевтических и косметических составах.

Process for the preparation of acetic acid and / or methyl acetate in the presence of iridium and platinum