ЗАМЕЩЕННЫЕ БИАРИЛЬНЫЕ СОЕДИНЕНИЯ ИЛИ ЗАМЕЩЕННЫЕ ПИРИДИНЫ И ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ НА ИХ ОСНОВЕ

FIELD: organic chemistry, medicine, endocrinology, pharmacy. SUBSTANCE: invention relates to biaryl compounds or substituted pyridines of the formula (I) where X means N or CR 8 where R 8 means hydrogen atom, halogen atom, phenyl, alkyl, alkoxy-group, alkoxycarbonyl, carboxy-group, formyl or -NR 4 R 5 where R 4 and R 5 mean hydrogen atom, alkyl, alkenyl, cycloalkyl, phenyl, naphthyl; R 1a and R 1в mean trifluoromethyl, alkyl, alkenyl, alkynyl, cycloalkyl, alkanoyl; R 2 means alkyl, alkenyl, alkynyl, cycloalkyl; R 3 means hydroxy-group, trifluoroacetyl, alkanoyl, alkenyl; Ar means aromatic or heteroaromatic ring, for example, phenyl, naphthyl, pyridyl, furanyl, thiophenyl. Compounds of the formula (I) show antagonistic effect with respect to glucagon receptor and can be used in treatment of glucagons-mediated states, for example, diabetes mellitus. EFFECT: valuable medicinal properties of compounds. 20 cl, 2 tbl 2195443 С2 КО РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ, ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ (11) , ® № \ х < (51) МПК7 С С 7 27 ( 22 7 27 < ‚= (13) а ( _^ х С2 С 07С 33/24, 39/12, 39/205, С 070 213/30, 213/32, 2413/36, 403/04, 403/06, 407/04, 413/04, 417/04, 419/04, А 61 К 31/44, 31/4427, А 61 Р 3/10//(С 07 О 403/04, 213:36, 241:26) 7%, ПЖ 2 (12) ИЗВЕЩЕНИЯ К ПАТЕНТУ НА ИЗОБРЕТЕНИЕ (21), (22) Заявка: 99104527/04, 29.07.1997 (24) Дата начала отсчета срока действия патента: 29.07.1997 (30) Конвенционный приоритет: 31.07.1996 9$ 08/690,111 (43) Дата публикации заявки: 20.01.2001 (46) Опубликовано: 27.12.2002 (56) Список документов, цитированных в отчете о поиске: ЕР 0306929 А2, 15.03.1989. ЕР 0325129 А2, 26.07.1989. ЕР 0325130 АЗ, 26.07.1989. ЕР 0603699 А, 29.06.1994. $Ц 539878 А, 25.12.1976. (85) Дата перевода заявки РСТ на национальную фазу: 01.03.1999 (86) Заявка РСТ: 1$ 97/13248 (29.07.1997) (87) Публикация РСТ: М/О 98/04528 (05.02.1998) Адрес для переписки: 103064, Москва, ул. Казакова, 16, НИИР- Канцелярия "Патентные ...

СИММЕТРИЧНЫЕ И НЕСИММЕТРИЧНЫЕ ПРОИЗВОДНЫЕ ДИФЕНИЛМОЧЕВИНЫ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СПОСОБ ПОДАВЛЕНИЯ РОСТА ОПУХОЛЕВЫХ КЛЕТОК, ОПОСРЕДОВАННОГО КИНАЗОЙ RAF

Изобретение относится к новым производным дифенилмочевины формулы (I) или их фармацевтически приемлемым солям, которые могут быть использованы при лечении опухолей, опосредованных киназой raf. В общей формуле (I) соединений настоящего изобретения: (I) А означает R3 означает Н, галоген, NO2, С1-10алкил, по выбору замещенный галогеном вплоть до полного замещения; С1-10алкокси, по выбору замещенный галогеном вплоть до полного замещения; R4, R5 и R6 каждый независимо означает Н, галоген, NO2, С1-10 алкил, по выбору замещенный галогеном вплоть до полного замещения; С1-10алкокси, по выбору замещенный галогеном вплоть до полного замещения; и либо один из R4, R5 и R6 по выбору означает -X-Y; либо два соседних R4, R5 и R6 могут быть объединены с основным фенильным кольцом с образованием нафтила или индольной группы, замещенной пиридинильной группой, Х означает -CH2-, -S-, -N(СН3)-, -NHC(O)-, -CH2-S-, -S-CH2, -С(O)-, или -О-. Значения других радикалов указаны в формуле изобретения. Изобретение также ...

АРИЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ЛИГАНДОВ PPAR И ИХ ПРИМЕНЕНИЕ

Изобретение относится к соединению формулы I ! ! где А представляет собой S или Se; В представляет собой Н или ! ; R1 представляет собой арил, выбранный из следующих структур: ! ! R2 представляет собой Н или ; R3 представляет собой Н или С1-С8 алкил; R4 и R5 независимо представляют собой Н или С1-С8 алкил; R6 представляет собой H, С1-С8 алкил, С2-С7 алкенил, щелочной металл или щелочноземельный металл; R11 и R12 независимо представляют собой Н, С1-С8 алкил или галоген; R21 представляет собой Н, галоген или С1-С7 алкил; m и n независимо представляют собой целые числа, имеющие значения 1-4; р представляет собой целое число, имеющее значение 1-5; q представляет собой целое число, имеющее значение 1-4; r представляет собой целое число, имеющее значение 1-3; s представляет собой целое число, имеющее значение 1-5; в качестве активатора рецептора активатора пролиферации пероксисом (PPAR) и его гидрату, сольвату, стереоизомеру и фармацевтически приемлемой соли и к фармацевтической композиции, средству ...

4-АМИНОПИКОЛИНАТЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ГЕРБИЦИДОВ

FIELD: organic chemistry, herbicides, agriculture. SUBSTANCE: invention describes compounds of 4-aminopicolinic acid of the formula: (I) wherein X means hydrogen, halogen atom, C 1 -C 6 - alkoxy-group, C 1 -C 6 -alkylthio-group, nitro-group, trifluoromethyl; Y means halogen atom, C 1 -C 6 -alkoxy-group, trifluoromethyl, phenoxy-group; Z means halogen atom, C 1 -C 6 -alkoxy-group; W means -NO 2 , -N 3 , -NR 1 R 2 , wherein R 1 and R 2 mean independently hydrogen atom, C 1 -C 6 -alkyl, C 3 -C 6 -alkenyl, hydroxy-group, C 1 -C 6 -alkoxy-group, C 1 -C 6 -acyl; or R 1 and R 2 , taken in common with nitrogen atom represent pyrrolidine or pyrrol; and their agriculturally acceptable salts, C 1 -C 12 -esters or amides. Invention describes herbicide composition and method for control of weeds. Invention provides inhibition of wide spectrum of weeds in rice, wheat, maize plantings. EFFECT: valuable agricultural properties of compounds. 10 cl, 10 tbl, 32 ex 6уУ60ссс ПЧ Го (19) РОССИЙСКОЕ АГЕНТСТВО ПО ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ ВИ "” 2 220 959 ' (51) МПК? 13) СЛ С 070 213/79, А 01 М 43/40 12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ РОССИЙСКОЙ ФЕДЕРАЦИИ (21), (22) Заявка: 2002121652/04, 12.01.2001 (24) Дата начала действия патента: 12.01.2001 (30) Приоритет: 14.01.2000 1$ 60/176,720 (46) Дата публикации: 10.01.2004 (56) Ссылки: 4$ 3755338, 28.08.1973. ВЕ 788756, 13.03.1973. 4$ 3325212, 13.06.1967. КУ 2112774 СЛ, 10.06.1998. (85) Дата перевода заявки РСТ на национальную фазу: 14.08.2002 (86) Заявка РСТ: 1$ 0101177 (12.01.2001) (87) Публикация РСТ: М/О 01/51468 (19.07.2001) (98) Адрес для переписки: 129010, Москва, ул. Б. Спасская, 25, стр.3, ООО "Юридическая фирма Городисский и Партнеры", Н.Г.Лебедевой (72) Изобретатель: ФИЛДЗ Стефен Крэйг (1$), АЛЕКСАНДЕР Анита Ленора (1$), БАЛКО Терри Вилльям (1$), БЬЕЛЬК Лесли Энни (0$), БЮИСС Энн Мари (43), КИСЕ Рене Джоан (4$), КРУМЭЛ Карл Леопольд (1$), ЛО Вилльям Чи-Леунг (4$), ЛОУЭ Кристиан Томас (0$), РИЧБУРГ Джон Сандерс (4$), РУИЗ Джеймс Мэлвин ...

НОВЫЕ ПРОИЗВОДНЫЕ ВИНИЛКАРБОНОВОЙ КИСЛОТЫ И ИХ ТЕРАПЕВТИЧЕСКОЕ ПРИМЕНЕНИЕ

... 1. Соединение общей формулы (I) где Х1 представляет собой арил или гетероарил, каждый из которых необязательно замещен одним или несколькими заместителями, выбранными из галогена, гидрокси, циано, амино или карбокси; или С1-6-алкила, С3-6-циклоалкила, С2-6-алкенила, С2-6-алкинила, арила, аралкила, гетероарила, гетероаралкила, С1-6-алкокси, С3-6-циклоалкокси, арилокси, аралкокси, гетероаралкокси, С1-6-алкилтио, арилтио, С3-6-циклоалкилтио, С1-6-алкилкарбонила, арилкарбонила, С1-6-алкилсульфонила, арилсульфонила, С1-6-алкиламидо, ариламидо, С1-6-алкиламинокарбонила, С1-6 -диалкиламинокарбонила, С1-6-алкиламино, С1-6-диалкиламино или С3-6-циклоалкиламино, каждый из которых необязательно замещен одним или несколькими заместителями, представляющими собой галоген; и Х2 представляет собой арилен или гетероарилен, каждый из которых необязательно замещен одним или несколькими заместителями, выбранными из галогена, гидрокси, циано, амино или карбокси; или С1-6-алкила, С3-6-циклоалкила, С2-6-алкенила ...

ПОЛИМОРФЫ ИНГИБИТОРА ЦИСТЕИНПРОТЕАЗЫ N-(1-ЦИАНОЦИКЛОПРОПИЛ)-3-ЦИКЛОПРОПИЛМЕТАНСУЛЬФОНИЛ-2(R)-(2,2,2-ТРИФТОРО-1(S)-(4-ФТОРФЕНИЛ) ЭТИЛАМИНО) ПРОПИОНАМИДА

... 1. Соединение Формулы (I),имеющее полиморфную форму, рентгенограмма порошковой дифракции которой имеет характерные пики при приблизительно 6.19, 19.47 и 21.67° (2-тета) (Форма А).2. Соединение Формулы (I):,имеющее полиморфную форму, рентгенограмма порошковой дифракции которой имеет характерные пики при приблизительно 6.19, 8.52, 9.15, 14.42, 17.67, 18.79, 19.47, 19.74, 21.67, 23.16, 23.89, 25.31 и 27.06° (2-тета); ив спектре FT-ИК отмечаются пики при приблизительно 704, 731, 777, 791, 808, 822, 837, 856, 892, 921, 935, 987, 1008, 1028, 1053, 1080, 1115, 1128, 1161, 1180, 1230, 1261, 1288, 1361, 1418, 1465, 1513, 1548, 1607, 1663 и 3349 см(Форма А).3. Соединение Формулы (I):,имеющее полиморфную форму, рентгенограмма порошковой дифракции которой имеет характерный пик при приблизительно 5.65° (2-тета) (Форма В).4. Соединение Формулы (I):,имеющее полиморфную форму, рентгенограмма порошковой дифракции которой имеет характерный пик при приблизительно 5.65, 6.68, 10.12, 18.63, 19.40, 20.66, 21.47 ...

ИНГИБИТОРЫ 11БЕТА-ГИДРОКСИСТЕРОИДДЕГИДРОГЕНАЗЫ

... 1. Соединение формулы ! R1-CO-X-Y-Z-R2, ! в которой ! Х и Z каждый представляет собой необязательные группы, независимо выбранные из насыщенных или ненасыщенных углеродных цепей, имеющих 1-3 атома углерода в длину, ! Y представляет собой SO, S, SO2, CH=CH, CH2CH2 или О, ! R1 выбран из следующих групп ! ! ! где линия обозначает точку присоединения, ! R2 представляет собой гетероарильную группу, включающую 15 необязательно замещенное 5- или 6-членное кольцо, где кольцо содержит только углерод и по крайней мере один азот, или содержит только углерод и по крайней мере два азота и по крайней мере одну серу, ! и где (i) когда R1 представляет собой , и группа -CO-X-Y-Z-представляет собой CO-CH2-SO, СО-СН2-S или CO-CH2-SO2, то R2 является отличным от , и ! (ii) когда R1 представляет собой, , и группа -CO-X-Y-Z- представляет собой -СО-СН2-О-, то R2 является отличным от . ! 2. Соединение по п.1, где R1 представляет собой . ! 3. Соединение по п.1, где R1 представляет собой . ! 4. Соединение по п.1 ...

ФОСФОРНЫЕ ПРОИЗВОДНЫЕ В КАЧЕСТВЕ МОДУЛЯТОРОВ ХЕМОКИНОВЫХ РЕЦЕПТОРОВ

... 1. Соединение, имеющее Формулу I, его энантиомеры, диастереоизомеры, гидраты, сольваты, кристаллические формы и индивидуальные изомеры, таутомеры или их фармацевтически приемлемые соли:где Rявляется Н или замещенным или незамещенным Cвалкилом;Rявляется замещенным или незамещенным Cалкилом, замещенным или незамещенным ОСалкилом, замещенным или незамещенным гетероциклом, замещенным или незамещенным Сциклоалкилом, замещенным или незамещенным Сциклоалкенилом или замещенным или незамещенным Сарилом;Rявляется C-R;Rявляется C-R;Rявляется -P(O)R;Rявляется замещенным или незамещенным Cалкилом, замещенным или незамещенным гетероциклом, замещенным или незамещенным Сциклоалкилом, замещенным или незамещенным Сциклоалкенилом или замещенным или незамещенным Сарилом;Rявляется Н, замещенным или незамещенным Cалкилом, замещенным или незамещенным гетероциклом, замещенным или незамещенным Сциклоалкилом, замещенным или незамещенным Сциклоалкенилом, замещенным или незамещенным Сарилом, галогеном, замещенным ...

Способ получения производных сульфамилбензиламина или их солей

Способ получения производных тиоформамида

СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВО НЫХ ТИОФОРМАМИДА общей формулы 1 -х- Het где R - водород или С -С алкил, tlet - 3-пиридил, 4-пирйдш1, пир зинил, пнразинил или хино X - сера или кислород, У - сера, кислород-, валентная связь или метилен; ЕНИЯ .. или Het - 2-пиридил X - сера или кислород; У - сера, кислород или метилен; или Het - 2-пиридил, X - кислород; У валентная связь, от л и ч а ю щ и и с я тем, что сложный дитиоэфир формулы II , . --sr- NHei где Het, X и у имеют указанные значения; R - С -С -алкил, бензил или карбоксимётил, подвергают взаимодействию с избытком амина формулы III : К-БНг где R - имеет указанные значения, в органическом растворителе при 20-40amp;deg;С.

VERFAHREN ZUR HERSTELLUNG VON 6-ARYL-2-METHYL-PYRIDINEN.

NEUE ENTZUENDUNGSHEMMENDE UND IMMUNREGULATORISCHE PYRIDINE UND PYRIMIDINE

HEMMUNG DER RAF-KINASE UNTER VERWENDUNG VON SYMMETRISCH UND UNSYMMETRISCH SUBSTITUIERTEN HARNSTOFFEN

PHENYLBENZOESAEUREDERIVATE UND VERFAHREN ZU IHRER HERSTELLUNG

CYANGUANIDINE, IHRE SALZE, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL

INHIBITOREN DER PROTEIN-ISOPRENYL-TRANSFERASE

Einen neuen Hydrazid-Typ enthaltendes photographisches Material

Chemische Verfahren und Produkte

INDANDERIVATE ALS MUSCARINREZEPTORAGONISTEN

Thioethers containing a Carbonyl Group and their Acetals and Ketals

... 1,191,044. Thioethers containing the carbonyl group and acetals thereof. MERCK & CO. Inc. 22 July, 1968 [26 July, 1967; 10 May, 1968], No. 42399/69. Divided out of 1,191,042. Heading C2C. Novel compounds I and II wherein n is 1, 2 or 3, R signifies H, halogen, SH, CN, C 1-5 alkylsulphonyl, C 1-5 alkylsulphinyl, C 1-6 alkanoyl, trifluoroacetyl, C 1-5 haloalkyl, SO 2 NH 2 , di-(C 1-5 alkyl) sulphamoyl, CONH 2 , di-(C 1-5 alkyl) carbamoyl, OH, C 1-5 alkylthio, C 1-5 alkoxy, anisyl, phenyl, NO 2 , phenethyl, C 1-5 alkyl, methylenedioxy, anilino, N-(C 1-5 alkyl) anilino, (C 1-5 alkyl) phenyl, di-(C 1-5 alkyl) amino, cyelohexyl, phenoxy, NH 2 , acylamino, C 1-5 alkylamino, or C 2-5 alkenyl, R 3 and R 3 1 signify H, C 1-5 alkyl or phenyl, R 6 and R 6 1 signify H, C 1-5 alkyl, C 2-5 alkenyl, phenyl, naphthyl, thienyl or pyridyl or substituted phenyl or naphthyl in which the substituents are (R) n , R 7 is C 1-5 alkyl and R 1 signifies H, C 1-5 alkyl or phenyl and in a compound II with ...

2-(pyrid-2-yl)tetrahydrothiophene derivatives

Compounds of the formula: wherein R represents hydrogen or alkyl of 1 through 4 carbon atoms, and R1 and R2 represent hydrogen or alkyl of 1 through 15 carbon atoms, or alkyl of 1 through 15 carbon atoms substituted by one substituent selected from (i) hydroxy, (ii) alkylamino in which the alkyl radical is of 1 through 4 carbon atoms, (iii) dialkylamino in which the alkyl radicals are of 1 through 4 carbon atoms, (iv) phenyl, (v) carboxy, and (vi) alkoxycarbonyl in which the alkoxy radical is of 1 through 4 carbon atoms, or R1 and R2 together with the nitrogen atom to which they are attached represent a five- or six-membered heterocyclic radical, are new compounds. They possess pharmacological properties and are particularly useful in the treatment of gastro-intestinal ulcers.

PYRIDINE DERIVATIVES

The present invention relates to compounds of formula I I in which formula I X stands for O, S, R1 and R2 which can be the same or different stand for hydrogen, straight or branched, saturated or unsaturated, unsubstituted or substituted C1-C8-alkyl, or for ar-C1-C4-alkyl, aryl and ar being unsubstituted or substituted phenyl; R3, R4, R5, and R6 are the same or different and stand for hydrogen, halogen, pseudo halogen, cyano, nitro, amino, carboxy, hydroxy, alkyl, alkoxy; or R5 and R6 form an aromatic ring which is fused to the pyridyl ring, and which aromatic ring may substituted; provided that R1 and R2 cannot be hydrogen at the same time, and provided that when R5 and R6 both are chlorine and R1 is hydrogen, then R2 cannot be n-propyl; and salts and bioreversible derivatives thereof. The compounds of formula I are useful in the human and veterinary therapy, as they exert specific 5-lipoxygenase inhibition.

PYRIDINE AND PYRIMIDINE INTERMEDIATES

Novel heterocyclic compounds, process for preparing them and medical compositions containing them

Novel heterocyclic compounds shown by the formula wherein Het represents a 5-membered or 6-membered heterocyclic group which may have substituent(s); Z represents a sulfur atom or oxygen atom; X represents an oxygen atom or the unsubstituted or substituted imino group shown by N-R1 (wherein R1 is a hydrogen atom, a lower alkyl group, a cyano group, an unsubstituted or alkyl substituted carbamoyl group, an unsubstituted or lower alkyl substituted thiocarbamoyl group, or a lower alkanoylamino group); Y represents a hydrogen atom, a lower alkyl group which may have substituent(s), a cycloalkyl group of 3-6 carbon atoms, a lower alkenyl group, a lower alkynyl group, an aryl group which may have substituent(s), an aralkyl group which may have substituent(s), a hydroxyl group, a cyano group, a carbamoyl group, an amidino group, an alkanoyl group which may have been substituted by halogen atom(s), an alkanoylamino group, an arylcarbonylamino group, an alkylamino group, an arylamino group, an arylsulfamoyl ...

PYRIDYLMETHYLTHIORLKYL DERIVATIVES OF GUANIDINES AND 1,1-DIAMINO-2-SUBSTITUTED ETHYLENES

Compounds that modulate PPAR activity and methods for their preparation.

This invention discloses compounds that alter PPAR activity. The invention also discloses pharmaceutically acceptable salts of the compounds, pharmaceutically acceptable compositions comprising the compounds or their salts, and methods of using them as therapeutic agents for treating or preventing hyperlipidemia, hypercholesteremia, obesity, eating disorders, hyperglycemia, atherosclerosis, hypertriglyceridemia, hyperinsulinemia and diabetes in a mammal as well as methods of suppressing appetite.and modulating leptin levels in a mammal. The present invention also discloses methods for making the disclosed compounds.

Compounds that modulate PPAR activity and methods for their preparation

Process for the preparation of new ethers.

New derivatives of the thioformamide and their method of preparation.

New antibiotics of the class of the carbapénems and their pharmaceutical application.

Compounds that modulate PPAR activity and methods for their preparation.

New derivatives of the dibenzocycloheptadienne and their preparation.

Method of preparation of derived from ethylene.

New method of preparation of antibiotics.

Method of preparation of a compound antihistamine.

News mercaptoalcoylpyridines and their derivatives.

Compounds that modulate PPAR activity and methods for their preparation

Compounds that modulate PPAR activity and methods for their preparation

1-Ä (ADAMANTYL) ALKYLÜ-3 Ä (PYRIDINYL) ALKYLÜHARNSTOFF CONNECTIONS AS TNF .ALPHA HEMMER TO the TREATMENT OF AUTOCIMMUNE ILLNESSES

KOSMETISCHES MITTEL ZUR BEKAMPFUNG DES FETTIGEN UND UNASTHETISCHEN AUSSEHENS DES HAARES UND ZUR VERBESSERUNG DES AUSSEHENS DER HAUT

KOSMETISCHES MITTEL ZUR BEKAMPFUNG DES FETTIGEN UND UNASTHETISCHEN AUSSEHENS DES HAARES UND ZUR VERBESSERUNG DES AUSSEHENS DER HAUT

VERFAHREN ZUR HERSTELLUNG VON NEUEN 5-SULFAMOYLBENZOESAUREN, SOWIE VON DEREN SALZEN UND ESTERN

4-AMINOPICOLINATE AND YOUR USE AS HERBICIDES

VERFAHREN ZUR HERSTELLUNG VON NEUEN CEPHEMVERBINDUNGEN UND DEREN SALZEN

PROCEDURE FOR the PRODUCTION OF NEW ONE 5-SULFAMOYLBENZOESAUREN, AS WELL AS OF THEIR SALTS AND ESTERS

COSMETIC MEANS TO BEKAMPFUNG THE GREASY AND UNASTHETI APPEARANCE OF THE HAIR AND FOR THE IMPROVEMENT OF THE APPEARANCE OF THE SKIN

PROCEDURE FOR THE PRODUCTION OF NEW PYRIDINEN AND THEIR ALKANE ACID ESTERS, METHYLAETHERN AS WELL AS PHARMACEUTICAL ACCEPTABLE ONE ACID ADDITION SALTS

TRIAZOLOBENZAZEPINE, PROCEDURE AND INTERMEDIATE PRODUCTS FOR THEIR PRODUCTION AND THESE CONTAINING DRUGS.

AETHER AND THIOAETHER WITH HEILENDER EFFECT, THEIR PRODUCTION AND THESE CONTAINING PHARMACEUTICAL COMPOSITIONS.

PROCEDURE FOR THE DUENNSCHICHTCHROMATOGRAPHI SEPARATION FROM ENANTIOMEREN.

PROCEDURE FOR the PRODUCTION OF NEW ONE 5-SULFAMOYLBENZOESÄUREN, AS WELL AS OF THEIR SALTS AND ESTERS

Procedure for the production of new substituted 3-Benzylpyridinverbindungen

COSMETIC MEANS

Procedure for the production of new Cysteinderivaten

TRISUBSTITUTED PHENYL DERIVATIVES USABLE AS PDE IV HEMMER

Cosmetic means

Procedures for the production of new 4 (Pyridyl) - tetrahydropyranen, - tetrahydrothiopyranen or - piperidinen

INHIBITION OF THE RAF KINASE USING SYMMETRICAL AND ASYMMETRICAL SUBSTITUTED UREA

Piperidine and pyrrolidine derivatives displaying neuronal activity

1,3,5-tris(6-methylpyridin-2-yloxy)benzene derivatives and related compounds as NLRX1 ligands for treating inflammatory diseases

Provided are l,3,5-tris(6-methylpyridin-2-yloxy)benzene derivatives and related compounds that target the nucleotide-binding oligomerization domain, leucine rich repeat containing XI (NLRX1) pathway. The compounds can be used to treat multiple conditions, including inflammatory, immune-mediated, and/or chronic inflammatory gastrointestinal diseases, systemic immune-mediated diseases, cancers and infectious diseases.

GUANIDINE DERIVATIVES

Benzoic acid derivatives that are modulators or agonists of GLYR

Process for the preparation of 2-substituted-5-(1-alkylthio) alkylpyridines

Pesticides

Compounds having the following generic Formula (I) and their use in controlling pests are disclosed.

Phenyl(oxy/thio)alkanol derivatives

The present invention relates to novel phenyl(oxy/thio)alkanol derivatives, to methods for producing said compounds, to agents containing said compounds, and to the use thereof as biologically active compounds, in particular for controlling harmful microorganisms in plant protection and in material protection and as plant growth regulators.

Metalloproteinase inhibitors, pharmaceutical compositions containing them and their pharmaceutical uses

POTASSIUM CHANNEL MODULATORS

Aromatic thioether liver x-receptor modulators

SULFAMYLBENZOIC ACID DERIVATIVES

INDOL-3-ACETIC ACID DERIVATIVES

Phosphorous derivatives as chemokine receptor modulators

The present invention relates to novel phosphorous derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

Coumpounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases

Naphtalene derivatives and their pharmaceutical use

Benzocycloheptenes, method for the production thereof, pharmaceutical preparations containing these compounds, and their use for producing medicaments

TNF-.ALPHA. PRODUCTION INHIBITORS

A purpose of the present invention is to provide TNF-.alpha. production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-.alpha. production inhibitory activities, (see formula 1) wherein "A" is -(NR4)- , -(CR5R6)- or -O-, "B" is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and "X" is oxygen or sulfer respectively.

PROCESS FOR THE PREPARATION OF 2-SUBSTITUTED-5-(1-ALKYLTHIO)ALKYLPYRIDINES

... 2-Substituted-5-(l-alkylthio)alkylpyridines are produced efficiently and in high yield.

FLUORINATED OXA OR THIA HETEROARYLALKYLSULFIDE DERIVATIVES FOR COMBATING INVERTEBRATE PESTS

The invention relates to alkylsulfide derivatives compounds of formula I as hererunder depicted or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to methods for controlling invertebrate pests by using these compounds and to plant propagation material and to agricultural and veterinary compositions comprising said compounds. wherein U, R1, R2, R3U, X, n and p are defined as in the description.

PHARMACOLOGICALLY ACTIVE COMPOUNDS

.ALPHA.,.ALPHA.-DISUBSTITUTED AROMATICS AND HETEROAROMATICS AS COGNITIONENHANCERS

Cognitive defeciencies or neurological dysfunction in mammals are treated with .alpha., .alpha.-disubstituted aromatic or heteroaromatic compounds. The compounds have the formula: (See Fig. I) or a salt thereof wherein X and Y are taken together to form a saturated or unsaturated carbocyclic or heterocyclic first ring and the shown carbon in said ring is .alpha. to at least one additional aramatic ring or heteroaromatic ring fused to the first ring; one of Het1 or Het2 is 2, 3, or 4-pyridyl or 2, 4, or 5-pyrimidinyl and the other is selected fran (a) 2, 3, or 4-pyridyl, (b) 2, 4, or 5-pyrimidinyl, (c) 2-pyrazinyl, (d) 3, or 4-pyridazinyl, (e) 3, or 4-pyrazolyl, (f) 2, or 3-tetrahydrofuranyl, and (g) 3-thienyl.

CYANOGUANIDINES

COMPOSITIONS A BASE DE DERIVES OU HOMOLOGUES DE LA CYSTEAMINE

ADO-RESISTANT CYSTEAMINE ANALOGS AND USES THEREOF

The present invention is directed to ADO-resistant cysteamine analogs for use in methods of treating diseases for which cysteamine is indicated, in particular cystinosis, fatty liver disease, fibrosis, thrombotic diseases, MECP-2 related disorders, inherited mitochondrial diseases, neurological diseases or disorders, inflammation and cancer.

PYRIDINE-SUBSTITUTED BENZYL ALCOHOLS AS LEUKOTRIENE ANTAGONISTS

... 2132723 9321158 PCTABS00027 Compounds having formula (I) are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

STYRYL COMPOUNDS AND THEIR PHARMACEUTICAL USE

... styryl compound of the formula(I): (I) wherein each symbol is as defined in the specification, a pharmaceutically acceptable salt or an ester thereof is disclosed. Since the compounds of the present invention possess potent and long-lasting leukotriene-antagonistic actions and inhibitory actions against leukotriene, and exhibit better absorption by the oral administration. Further, the compounds of the present invention possess 5lipoxygenase-inhibitory actions and/or cyclooxygenaseinhibitory actions, inhibitory actions to biosynthesis of LTB4, chemotactic actions against human leucocyte, chymase-inhibitory actions, inhibiyory actions to release of histamine or antihistamine actions. Therefore, they are useful as the prophylactic and therapeutic medicines for brochial asthma, chronic bronchitis, atopic dermatitis, allergic rhinitis, allergic arthritis, allergic conjunctivitis, hay fever, urticaria, alimentary allergy, pain, pyretolysis, rheumatoid, thrombosis, coronary vascular diseases, ...

HERBICIDAL (4-SUBSTITUTED PYRIDYL)-3-CARBINOLS

... (4-substituted pyridyl)-3-carbinols of formula (1), wherein R is hydrogen, or an acyl alkyl or carbamyl group exhibit desirable preemergent and postemergent herbicidal activity. Also disclosed herbicidal compositions comprising such compounds; and a method of controlling undesirable vegetation employing such com pounds. The compounds wherein AR is hydroxyl serve as useful intermediate for the production of the alphabenzyl substituted compounds as well as exhibiting herbicidal activity.

Verfahren zur Herstellung von Äthern und Thioäthern des Panthenols

Verfahren zur Herstellung neuer N-substituierter Piperidine

Verfahren zur Herstellung neuer Pyridinabkömmlinge

Procédé de préparation de nouvelles amines

Produit cosmétique, utilisable par voie orale, permettant d'améliorer l'apparence des cheveux ayant tendance à présenter un aspect graisseux

Verwendung von Pyridinbasenverbindungen als Fungicid

Verfahren zur Herstellung von neuen Äthern

Verfahren zur Herstellung von Bipyridylen

Aralkyl thioamino acids - anti-inflammatory

Process for cpds. of formula (I), and some cpds. (I): R = H, halogen, SH, CN, SO2alkyl, SO alkyl, alkanoyl, CF3CO, haloalkyl, SO2NH2, SO2N(alkyl)2, CONH2, CON(alkyl)2, OH, S-alkyl, O-alkyl, anisyl, Ph, NO2, phenethyl, alkyl, OCH2O, PhNH-, PhN(alkyl)-, alkylphenyl, N(alkyl)2, cyclohenyl, PhO, NH2, NHacyl, NHalkyl, or alkenyl. R may be substd. by Ph or naphthyl. R2 = OH, O-alkyl, O-alkenyl, O-alkynyl, cyclopropyl-methyloxy, alkoxyalkoxy, polyalkoxyalkoxy, dialkyl-aminoalkoxy, piperidinoalkoxy, 1-pyrrolidenylalkoxy, morpholinoalkoxy, 1-alkyl-2-pyrolidinyalkoxy, 1-alkyl-2-piperidino-alkoxy, N'-alkyl-N-piperazinyl-alkoxy, PhO, p-alkanoylaminophenoxy, phenylalkoxy, carbamylphenoxy, tetrahydrofurfuryloxy, dialkylamino-cyclohexyloxy, NH2, NHalkyl, N(alkyl)2, glucosamino, glycosylamino, alkenylamino, phenylalkylamino, haloanilino, 1-alkylpiperidinyl-2-alkylamino, tetrahydrofuryfurylamino, 1,2,5,6-tetrahydropyridino, morpholino, N'-alkyl-N-piperazinyl, piperazino, N-phenylpiperazino, piperidino, ...

Verfahren zur Herstellung von substituierten Pyridinen

Verfahren zur Herstellung von Phenylen-bis-dithio-carbaminsäureestern

Phosphorous derivatives as chemokine receptor modulators

The present invention relates to novel phosphorous derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

Aryl compounds as ppar ligands and their use

The present invention relates to a compound as a peroxisome proliferator activated receptor (PPAR) activator and a hydrate, a solvate, a stereoisomer and a pharmaceutically acceptable salt thereof, and a pharmaceutical composition, a cosmetic composition, a muscle strengthening agent, a memory improving agent, a therapeutic agent for dementia and Parkinson's disease, a functional food and a feed composition containing the same.

Novel amides as fungicides

Compounds of the general formula (I), wherein the substituents are as defined in claim 1 , are useful as fungicides.

PHENYLTHIOACETATE COMPOUNDS, COMPOSITIONS AND METHODS OF USE

Described herein are compounds useful in the modulation of blood uric acid levels, formulations containing them and methods of using them. In some embodiments, the compounds described herein are used in the treatment or prevention of dis orders related to aberrant levels of uric acid. 2. (canceled)4. A compound of claim 3 , wherein{'sup': 'y', 'Ris H; and'}{'sup': 'z', 'Ris H.'}5. A compound of claim 4 , wherein Ris CN claim 4 , CHOH or C(O)NH.6. A compound of claim 5 , wherein M is H.7. A compound of claim 5 , wherein M is a pharmaceutically acceptable cation.8. A compound of claim 3 , wherein{'sup': a', 'b, 'sub': 3', '3, 'Ris CHand Ris CH; or'}{'sup': a', 'b, 'Rand Rtogether with the carbon atom to which they are attached form a cyclobutyl ring.'}9. A compound of claim 3 , wherein{'sup': 'w', 'Ris H;'}{'sup': 'x', 'sub': 2', '2, 'Ris CN, CHOH or C(O)NH;'}{'sup': 'y', 'Ris H;'}{'sup': 'z', 'Ris H;'}M is H; and{'sup': a', 'b, 'sub': 3', '3, 'Ris CHand Ris CH; or'}{'sup': a', 'b, 'Rand Rtogether with the carbon atom to which they are attached form a cyclobutyl ring.'}10. (canceled)12. (canceled)14. A compound of claim 1 , wherein{'sup': 'a', 'sub': '3', 'Ris CH; and'}{'sup': 'b', 'sub': '3', 'Ris CH.'}15. A compound of claim 1 , wherein Rand Rtogether with the carbon atom to which they are attached form a 3- claim 1 , 4- claim 1 , 5- or 6-membered ring.17. A compound of claim 1 , wherein each R claim 1 , R claim 1 , Rand Ris H.18. A compound of claim 1 , wherein{'sup': 1', '2', '3', '4, 'each R, R, Rand Ris H;'}W is CH; and{'sup': 'x', 'X is CR.'}19. A compound of claim 1 , wherein Ris fluorine.23. (canceled)24. (canceled)25. (canceled)26. (canceled)27. The method of claim 22 , wherein the condition is gout claim 22 , a recurrent gout attack claim 22 , gouty arthritis claim 22 , hyperuricaemia claim 22 , hypertension claim 22 , a cardiovascular disease claim 22 , coronary heart disease claim 22 , Lesch-Nyhan syndrome claim 22 , Kelley-Seegmiller syndrome claim 22 , ...

SULFUR DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors. 2. A compound according to claim 1 , wherein:{'sup': '5', 'Ris S.'}3. A compound according to claim 1 , wherein:{'sup': '5', 'Ris —S(O)—.'}4. A compound according to claim 1 , wherein:{'sup': '5', 'sub': '2', 'Ris —S(O)—.'}5. A compound according to claim 1 , wherein:{'sup': '1', 'Ris H;'}{'sup': '2', 'sub': 1-6', '3-8', '3-8, 'Ris substituted or unsubstituted Calkyl, substituted or unsubstituted Ccycloalkyl or substituted or unsubstituted Ccycloalkenyl;'}{'sup': '5', 'sub': '2', 'Ris —S—, —S(O)—, or —S(O)—;'}{'sup': '6', 'Ris 4-chloro-3-trifluoromethylphenyl;'}{'sup': '17', 'sub': '1-6', 'Ris H, substituted or unsubstituted Calkyl or halogen;'}{'sup': '18', 'sub': '1-6', 'Ris H, substituted or unsubstituted Calkyl or halogen;'}{'sup': '7', 'sub': 1-6', '1-6', '3-8, 'Ris H, halogen, CN, —OCalkyl, substituted or unsubstituted Calkyl or substituted or unsubstituted Ccycloalkyl; and,'}{'sup': '8', 'sub': '1-6', 'Ris H, substituted or unsubstituted Calkyl, CN or halogen.'}6. A compound according to claim 5 , wherein:{'sup': '1', 'Ris H;'}{'sup': '2', 'sub': '1-6', 'Ris substituted or unsubstituted Calkyl;'}{'sup': '5', 'sub': '2', 'Ris —S—, —S(O)—, or —S(O)—;'}{'sup': '6', 'Ris 4-chloro-3-trifluoromethylphenyl;'}{'sup': '17', 'Ris H;'}{'sup': '18', 'Ris H;'}{'sup': '7', 'sub': '1-6', 'Ris halogen or Calkyl; and,'}{'sup': '8', 'Ris H.'}7. A compound according to claim 6 , wherein:{'sup': '1', 'Ris H;'}{'sup': '2', 'Ris benzyl, methyl-4-benzoic acid, tert-butyl 2-(4-methylbenzamido)acetate, tert-butyl 2-(4-methyl benzamido)acetic acid, methyl-3-methylbenzoate, 4-methyl-N-(2-(pyrrolidin-1-yl)ethyl)benzamide, 4-methyl-N-(2-(1-oxipyrrolidin-1-yl)ethyl)benzamide, 3-methyl-N-(2-(pyrrolidin-1-yl)ethyl)benzamide, methyl-2-methylbenzoate, methyl-2-benzoic acid, N,N- ...

STABLE HOMOGENEOUSLY MIXED NANOSCALE COATINGS DERIVED FROM UNIQUE MULTI-FUNCTIONAL AND MULTIDENTATE AROMATIC ADSORBATES

Novel tridentate-, bidentate-, and monodentate-based aromatic adsorbates including self-assembled monolayers (SAMs), especially, mixed multi-component SAMs, where the adsorbates comprise an aromatic ring including one head group or a plurality of dentate head groups and one tunable tail group or a plurality of tail groups and methods for making the same, and methods for using same, their use in the preparation of homogeneously mixed multi-component self-assembled monolayers (SAMs). The adsorbants and SAMs derived therefrom are ideally suited for biosensing, biosensing diagnostics, biological interfacial mimics, surface protections for nanoparticles, inert coatings for artificial implants, and corrosion-resistant coatings for microelectronics components. 1. A method for preparing homogeneously self-assembled monolayers (SAMs) comprising:adsorbing a mono-dentate absorbate, a bi-dentate absorbate, a tri-dentate absorbate or a mixture or combination thereof onto a surface of a substrate to form a SAM modified surface,where the adsorbates comprise an aromatic ring including one dentate head group or a plurality of dentate head groups and one tunable tail group or a plurality of tunable tail groups, andwhere the SAM exhibit: (1) homogenous lateral chain distributions, (2) no or substantially no phase separation or islanding across SAM modified surfaces, and (3) enhanced stability as compared to a corresponding linear alkyl thiol monodentate adsorbate.2. The method of claim 1 , wherein the surface comprises a metal surface.3. The method of claim 1 , wherein the absorbate or mixture thereof comprise one monodentate adsorbate or a mixture of monodentate absorbates.4. The method of claim 1 , wherein the absorbate or mixture thereof comprise one bidentate adsorbate or a mixture of bidentate absorbates.5. The method of claim 4 , wherein the bidentate adsorbate or the mixture of bidentate absorbates comprise a non-symmetrical spiroalkanedithiol or a mixture of non-symmetrical ...

Small molecule inhibitors of xbp1 splicing

Small molecule inhibitors of XBP1 splicing by IRE1 are provided, as well as methods for their use in treating or preventing cancer (e.g., endocrine resistant breast cancer), diabetes, and obesity.

ADO-RESISTANT CYSTEAMINE ANALOGS AND USES THEREOF

The present disclosure is directed to methods for treating diseases for which cysteamine is indicated and compounds useful in such methods. 2. The method of claim 1 , wherein Rand Rare independently selected from the group consisting of H claim 1 , methyl claim 1 , and ethyl.3. The method of claim 1 , wherein Rand R claim 1 , taken together with the nitrogen atom to which they are attached claim 1 , form a 5-membered heterocyclic ring.4. The method of claim 1 , wherein Ris methyl claim 1 , optionally wherein Ris methyl.5. (canceled)6. The method of claim 1 , wherein Rand R claim 1 , taken together with the carbon atom to which they are attached claim 1 , form a 3-membered carbocyclic ring.7. The method of claim 1 , wherein Ris methyl claim 1 , optionally wherein Ris methyl.8. (canceled)9. The method of claim 1 , wherein Rand R claim 1 , taken together with the carbon atom to which they are attached claim 1 , form a 3-membered carbocyclic ring.10. The method of claim 1 , wherein G is —CRRNRR claim 1 , and Rand R claim 1 , taken together with the atoms to which they are attached claim 1 , form a 6-membered heterocyclic ring claim 1 , optionally wherein Ris methyl.11. (canceled)12. The method of claim 1 , wherein G is —NRR claim 1 , and Rand R claim 1 , taken together with the atoms to which they are attached claim 1 , form a 4- or 6-membered heterocyclic ring.13. (canceled)14. (canceled)17. (canceled)18. (canceled)20. The method of wherein L is a 3- claim 19 , 4- claim 19 , 5- claim 19 , 6- claim 19 , 7- claim 19 , or 8-membered cycloalkyl ring or a 6-membered aryl ring.21. The method of wherein L is Calkyl.22. (canceled)23. The method of wherein A is a 3- claim 19 , 4- claim 19 , 5- claim 19 , 6- claim 19 , 7- claim 19 , or 8-membered monocyclic heterocycloalkyl ring claim 19 , a 6- claim 19 , 7- claim 19 , or 8-membered bicyclic heterocycloalkyl ring claim 19 , or a 5- or 6-membered heteroaryl ring.25. (canceled)26. (canceled)27. (canceled)28. (canceled)29. The ...

SUBSTITUTED BICYCLIC COMPOUNDS

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): 3. The compound according to claim 2 , having the structure of Formula (I) or a salt thereof claim 2 , wherein:{'sub': 1', '2, 'Ris —OH or —OP(O)(OH);'}{'sub': 2', '2a', '2b, 'Ris Ror R;'}{'sub': '2a', 'claim-text': [{'sub': 2', '3', '3', '2', '5', '3', '2', '2', '3', '2', '2', '2', '3', '2', '3', '3', '2', '3', '3', '2', '2', '4', '2', '2', '4', '3', '2', '3', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '3', '2', '3', '2', '2', '2', '3, 'is —(CH)CH, —(CH)CH, —CHCH═CHCHCH, —CHCHCH═CHCHCH, —(CH)CH═CHCH, —(CH)CH═C(CH), —(CH)CH═CH, —(CH)CH═CHCH, —CH═C H(CH)CH, —CH═CH(CH)OCH, —CH═CHCHCHCH(CH), —CH═CHCHCHCHOCH, —CHCH═CHCH═CHCH, —CH═CHCHCHCH═CH, —CH═CH(phenyl) wherein said phenyl is substituted with —CH'}, {'sub': 3', '2', '1-3', '3', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '2', '2', '1-2, 'or —OCH; —CH═CH(tetrahydropyranyl), —(CH)(phenyl) wherein said phenyl is substituted with zero to 2 substituents independently selected from F, I, —CH, —OCH, —OCHCH, —OCH(CH), and —CHC(O)N(CH); —(CH)(methyl imidazolyl), —(CH)(methyl pyrazolyl), —(CH)(pyridinyl) wherein said pyridinyl is substituted with zero to 1 substituent selected'}, {'sub': 3', '2', '2', '2', '2', '2', '2-3', '2', '2', '3-4', '3', '2', '2', '2', '3', '2', '2', '2', '2', '3', '3', '2', '2', '9', '3', '2', '2', '2', '2', '3', '2', '2', '2', '3', '2', '2', '3', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '3', '2', '3', '3', '2', '3', '3', '3', '3', '2', '1-6', '3', '3', '2', '2', '3', '2', '2', '3', '3', '3', '2', '2', '2', '3, 'from —OCH; —(CH)(pyrimidinyl), —(CH)(quinolinyl), —(CH)(tetrahydropyranyl), —CHO(CH)CH, —CHOCHCHCH(CH), —CHOCHCHC(CH), —CHO(CH)CH, —CHOCHCHCHCF, —CHOCHCH═CHCHCH, —CHOCHCH═C(CH), —CHOCHCH═CHCHCHCH, — ...

Sulfur derivatives as chemokine receptor modulators

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

ORGANOACTINIDE-, ORGANOLANTHANIDE-, AND ORGANOGROUP-4-MEDIATED HYDROTHIOLATION OF TERMINAL ALKYNES WITH ALIPHATIC, AROMATIC AND BENZYLIC THIOLS

An efficient and highly Markovnikov selective organoactinide-, organolanthanide-, and organozirconium-catalyzed addition of aryl, benzyl, and aliphatic thiols to terminal alkynes is described. The corresponding vinyl sulfides are produced with little or no side-products. 2. A vinyl sulfide of wherein the catalyst is selected from CpSmN(TMS) claim 1 , MeSiCp″Th[CH(TMS)]. CGCZrMe claim 1 , CpYCH(TMS) claim 1 , MeSiCp″UBn claim 1 , CpZrMe claim 1 , CGCSmN(TMS) claim 1 , CGCU(NMe) claim 1 , Cp*ZrBn claim 1 , La[N(TMS)] claim 1 , CGCTh(NMe) claim 1 , Zr[NMe] claim 1 , Nd[N(TMS)] claim 1 , U(NEt) claim 1 , Cp*ZrClNMe claim 1 , Lu[CH(TMS)] claim 1 , CpU(NMe) claim 1 , Y[N(TMS)] claim 1 , CpTh(CHTMS) claim 1 , CpLaCH(TMS) claim 1 , CpU(CHTMS) claim 1 , CpSmCH(TMS) claim 1 , and CpLuCH(TMS).3. A vinyl sulfide according to selected from the group consisting ofa) hex-1-en-2-yl(pentyl)sulfane;b) cyclohexyl(hex-1-en-2-yl)sulfane;c) hex-1-en-2-yl(4-methylbenzyl)sulfane;d) pentyl(1-phenylvinyl)sulfane;e) (1-(cyclohex-1-en-1-yl)vinyl)(pentyl)sulfanef) (1-cyclohexylvinyl)(pentyl)sulfane;g) (1-cyclohexylvinyl)(4-methylbenzyl)sulfane;h) ethyl(hex-1-en-2-yl)sulfane;i) hex- 1-en-2-yl(2,2,2-trifluoroethyl)sulfane;j) benzyl(hex-1-en-2-yl)sulfane;k) (3-cyclohexylprop-1-en-2-yl)(pentyl)sulfane;l) pentyl(3-phenylprop-1-en-2-yl)sulfane;m) 3-(1-(pentylthio)vinyl)pyridine; andn) 2-(pentylthio)prop-2-en-1-amine. This application is a divisional of and claims priority to U.S. application Ser. No. 12/856,154 filed Aug. 13, 2010, which claimed priority to U.S. provisional application Ser. 61/233,541 filed Aug. 13, 2009-each of which is incorporated herein by reference in its entirety.This invention was made with government support under Grant No. CHE0809589 awarded by the National Science Foundation. The government has certain rights in the invention.The present invention relates generally to atom-efficient organoactinide-, organolanthanide-, and organoGroup-4-catalyzed intermolecular ...

FLAVOR MODULATOR HAVING PYRIDINE DERIVATIVE OR SALT THEREOF AS ACTIVE INGREDIENT

2-(phenylalkyloxyalkyl)pyridine derivative or a 2-(phenylalkylthioalkyl)pyridine derivative imparts, when added to food and drink or cosmetics as an active ingredient, a flavor of natural impression thereto; and in particular, when added to food and drink, the compound imparts an umami imparting or enhancing, a saltiness enhancing a sweetness enhancing, and in particular, when added to a milk or dairy product, a food or drink product containing a milk or dairy product, or a dairy replacement product, the compound provides a milk richness enhancing. 3. The flavor modulator according to claim 1 , wherein the flavor modulation is flavor impartment or enhancement.4. The flavor modulator according to claim 1 , wherein the flavor modulation is umami impartment.5. The flavor modulator according to claim 1 , wherein the flavor modulation is umami enhancement.6. The flavor modulator according to claim 1 , wherein the flavor modulation is sweetness enhancement.7. The flavor modulator according to claim 1 , wherein the flavor modulation is saltiness enhancement.8. The flavor modulator according to claim 1 , wherein the flavor modulation is milk richness enhancement for a milk or dairy product claim 1 , a food or drink product containing a milk or dairy product claim 1 , or a dairy replacement product.9. A flavor composition for food and drink claim 1 , comprising the flavor modulator according to as an active ingredient.10. A food or drink product comprising the flavor modulator according to .11. The flavor composition for cosmetics comprising the flavor modulator according to as an active ingredient.12. A cosmetic product comprising the flavor modulator according to .13. A flavor imparting or enhancing method for food and drink or cosmetics claim 1 , wherein a compound represented by the formula (1) or a salt thereof in is contained in a food or drink product or in a cosmetic product.14. An umami imparting or enhancing method for food and drink claim 1 , wherein a compound ...

High-throughput method to rapidly add chemical moieties to a small molecule library

Organic compounds for target identification, drug discovery, chemical library production, high-throughput screening, fluorophore conjugation, chemiluminescent compound conjugation, creation of proximity induced modulators (e.g., protein degraders)/chimeric molecules, or a combination thereof are described. The compounds can contain small molecule moieties for identification of their potential targets; an isocyanate, photoactivatable groups; chemical moieties for enrichment and detection of target-small molecule moiety interactions; proximity induced modulator element; fluorophores; chemiluminescent groups; or combinations thereof.

SUBSTITUTED BICYCLIC COMPOUNDS

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): 116-. (canceled)19. The compound according to or a salt thereof claim 17 , wherein:{'sub': 2a', '2', '3', '3', '2', '5-6', '3', '2', '2', '3', '2', '2', '2', '3', '2', '3', '3', '2', '3', '3', '2', '2', '4', '2', '2', '4', '3', '2', '3', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '3', '2', '3', '2', '2', '2', '3', '3', '2', '1-3', '3', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '2', '2', '1-2', '3', '2', '2', '2', '2', '2', '2-3', '2', '2', '3-4', '3', '2', '2', '2', '3', '2', '2', '2', '2', '3', '3', '2', '2', '9', '3', '2', '2', '2', '2', '3', '2', '2', '2', '3', '2', '2', '3', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '3', '2', '3', '3', '2', '3', '3', '3', '3', '2', '1-6', '3', '3', '2', '2', '3', '2', '2', '3', '3', '3', '2', '2', '2', '3', '3', '2', '3', '2', '2', '2', '2', '2', '2', '3', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '3', '2', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '3', '2', '3', '2', '3', '2', '3', '2', '2', '2-4', '3', '2', '3', '2', '2', '2', '3', '2', '2', '2', '3', '3', '2', '2', '2', '3', '2', '2', '2', '2', '3', '3', '2', '2', '2', '3', '3', '2', '2', '2', '1-2', '3', '2', '2', '2', '3', '2', '2', '3', '3', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '3', '2', '2', '2', '3', '3', '2', '2', '2', '2', '4', '3', '2', '2', '4', '3', '3', '2', '4', '3', '2', '3', '2', '5', '3', '2', '2', '4-7', '3', '2', '2', '2', '2-4', '3', '2', '2', '2', '3', '2', '2', '2', '2-3', '3', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2-3', '3', ' ...

SULFUR DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors. 210.-. (canceled)11. A compound according to claim 1 , selected from:4-chloro-N-[5-chloro-2-(methylsulfinyl)phenyl]-3-methylbenzenesulfonamide;N-[5-chloro-2-(methylsulfinyl)phenyl]-3-nitro-4-(trifluoromethyl)benzenesulfonamide;4-chloro-N-[5-chloro-2-(methylthio)phenyl]-2-fluorobenzenesulfonamide;4-chloro-N-[5-chloro-2-(ethylthio)phenyl]-3-(trifluoromethyl)benzenesulfonamide;tert-Butyl {6-[({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}thio)methyl]pyridin-2-yl}carbamate;3-{[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]sulfonyl}-N,N-dimethylpropanamide;3-[(4-chloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)thio]-N,N-dimethylpropanamide;3-[(4-chloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)sulfinyl]-N,N-dimethylpropanamide;3-[(4-chloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)sulfonyl]-N,N-dimethylpropanamide;3-[(4-chloro-2-{[(4-chloro-2-fluorophenyl)sulfonyl]amino}phenyl)thio]-N,N-dimethylpropanamide;3-[(4-chloro-2-{[(4-chloro-2-fluorophenyl)sulfonyl]amino}phenyl)sulfinyl]-N,N-dimethylpropanamide;3-[(4-chloro-2-{[(4-chloro-2-fluorophenyl)sulfonyl]amino}phenyl)sulfonyl]-N,N-dimethylpropanamide;4-chloro-N-[5-chloro-2-(methylthio)phenyl]-3-(trifluoromethyl)benzenesulfonamide;4-chloro-N-[5-chloro-2-(isopropylthio)phenyl]-3-(trifluoromethyl)benzenesulfonamide;4-chloro-N-{5-chloro-2-[(2-hydroxyethyl)thio]phenyl}-3-(trifluoromethyl)benzenesulfonamide;4-chloro-N-[5-chloro-2-(isopropylsulfinyl)phenyl]-3-(trifluoromethyl)benzenesulfonamide;4-chloro-N-{5-chloro-2-[(pyridin-2-ylmethyl)thio]phenyl}-3-(trifluoromethyl)benzenesulfonamide;4-chloro-N-{5-chloro-2-[(pyridin-3-ylmethyl)thio]phenyl}-3-(trifluoromethyl)benzenesulfonamide;2-{[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]thio}-N,N-dimethylacetamide;2-{[ ...

Hafnium Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand. 2. The method of claim 1 , further comprising (2) combining an activating agent with the reaction product.4. The method of claim 3 , further comprising (2) combining a reducing agent with the reaction product.6. The method of claim 5 , further comprising (2) combining a reducing agent with the reaction product.7. The method of claim 6 , where the reaction product comprises a Hf-ligand complex and a by-product of reaction of the Hf precursor and the ligand or of a side reaction therein.8. The method of claim 7 , further comprising removing all or a portion of the by-product.9. (canceled)10. A composition comprising:{'claim-ref': {'@idref': 'CLM-00002', 'claim 2'}, '(A) a catalytically active reaction product prepared by the method of ;'}(B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction; and{'sup': 4', '4, 'sub': e', 'f, '(C) a silane of formula RSiH, where subscript e is 0, 1, 2, or 3; subscript f is 1, 2, 3, or 4, with the proviso that a sum of (e+f) is 4, and each Ris independently a halogen atom or a monovalent organic group.'}11. A composition comprising:{'claim-ref': {'@idref': 'CLM-00006', 'claim 6'}, '(A) a catalytically active reaction product prepared by the method of ;'}(B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of ...

SULFUR DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors. 115.-. (canceled)17. The method according to claim 16 , wherein:{'sup': '5', 'Ris —S—.'}18. The method according to claim 16 , wherein:{'sup': '5', 'Ris —S(O)—.'}19. The method according to claim 16 , wherein:{'sup': '5', 'sub': '2', 'Ris —S(O)—.'}20. The method according to claim 16 , wherein the compound is selected from the group consisting of:3,4-dichloro-N-[5-chloro-2-(methylthio)phenyl]benzenesulfonamide;3,4-dichloro-N-[5-chloro-2-(methylsulfinyl)phenyl]benzenesulfonamide;4-chloro-N-[5-chloro-2-(methylsulfinyl)phenyl]-3-methylbenzenesulfonamide;N-[5-chloro-2-(methylsulfinyl)phenyl]-3-nitro-4-(trifluoromethyl)benzenesulfonamide;4-chloro-N-[5-chloro-2-(methylthio)phenyl]-2-fluorobenzenesulfonamide;4-chloro-N-{5-chloro-2-[(1H-imidazol-4-ylmethyl)sulfonyl]phenyl}-3-(trifluoromethyl)benzenesulfonamide;4-chloro-N-[5-chloro-2-(methylsulfinyl)phenyl]-3-(trifluoromethyl)benzenesulfonamide;4-chloro-N-[5-chloro-2-(ethylthio)phenyl]-3-(trifluoromethyl)benzenesulfonamide;4-chloro-N-[5-chloro-2-(ethylsulfinyl)phenyl]-3-(trifluoromethyl)benzenesulfonamide;tert-butyl {6-[({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}thio)methyl]pyridin-2-yl}carbamate;tert-butyl {6-[({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}sulfonyl)methyl]pyridin-2-yl}carbamate;tert-butyl 3-[({2-[(1-benzofuran-2-ylsulfonyl)amino]-4-chlorophenyl}thio)methyl]-1H-pyrazole-1-carboxylate;3-{[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]sulfinyl}-N,N-dimethylpropanamide;3-{[4-chloro-2-({[4-chloro-3-(trifluoromethyl)phenyl]sulfonyl}amino)phenyl]sulfonyl}-N,N-dimethylpropanamide;3-[(4-chloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)thio]-N,N-dimethylpropanamide;3-[(4-chloro-2-{[(2,4-difluorophenyl)sulfonyl]amino}phenyl)sulfinyl]-N,N-dimethylpropanamide;3-[(4-chloro-2 ...

SULFIDE-BASED COMPOUNDS AND USES THEREOF

Disclosed are sulfide-based compounds which are a product of a Michael addition reaction between a sulfur-containing donor group and an unsaturated hydrocarbon moiety. The sulfide-based compounds may be used in compositions and methods for inhibiting corrosion. 1. A composition comprising at least one sulfide-based compound , the at least one sulfide-based compound formed by a Michael addition reaction between a sulfa-Michael donor and an olefin as a Michael acceptor.2. The composition of of claim 1 , wherein the sulfa-Michael donor comprises a mercaptoalcohol.3. The composition of claim 1 , wherein the olefin comprises α claim 1 ,β-unsaturated carbonyl compounds.4. The composition of claim 3 , wherein the α claim 3 ,βunsaturated carbonyl compounds comprises a vinyl ketone claim 3 , a vinyl sulfone claim 3 , a quinone claim 3 , an enamine claim 3 , a ketimine claim 3 , an aldimine claim 3 , an oxazolidine claim 3 , and an acrylate claim 3 , acrylate esters claim 3 , acrylonitrile claim 3 , acrylamides claim 3 , maleimides claim 3 , alkyl methacrylates claim 3 , cyanoacrylates claim 3 , vinyl ketones claim 3 , α claim 3 ,β-unsaturated aldehydes claim 3 , vinyl phosphonates claim 3 , acrylonitrile claim 3 , vinyl pyridines claim 3 , azo compounds claim 3 , β-keto acetylenes claim 3 , acetylene esters claim 3 , nitro ethylenes.6. The composition of claim 1 , further comprising a solvent claim 1 , wherein the solvent is present in the composition at about 10 wt % to 99 wt % of the composition.7. A fluid source comprising one or more corrodents and at least one sulfide-based compound as in .8. The composition of claim 7 , wherein the fluid source comprises about 0.1% to about 25% weight/weight total dissolved solids.9. The composition of claim 1 , wherein the sulfide-based compound is about is about 0.1 ppm to 10 claim 1 ,000 ppm by weight or volume of the composition.12. A method of inhibiting corrosion of metal containments in contact with a fluid source comprising the ...

Iridium Containing Hydrosilylation Catalysts and Compositions Containing the Catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable, of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.

Sulfur derivatives as chemokine receptor modulators

The present invention relates to novel sulfur derivatives, processes for preparing them, pharmaceutical compositions containing them and their use as pharmaceuticals as modulators of chemokine receptors.

Molybdenum Containing Hydrosilylation Reaction Catalysts and Compositions Containing the Catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition ′ capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.

Transition metal luminescent complexes and methods of use

Described herein are transition metal complexes containing nickel(II), as the central metal atom, and tridentate and tetradentate ligands. The transition metal complexes also include an ancillary ligand with strong σ-donating properties. The ancillary ligand enhances the luminescence by increasing the chances of populating the emissive state. The transition metal complexes are emissive at room temperature and/or low temperature in various media, rendering them useful as light-emitting materials for OLEDs.

METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES

The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes. 239-. (canceled) This application claims the benefit of U.S. Provisional Patent Application Ser. Nos. 61/979,540 filed Apr. 15,2014 and 62/047,384 filed Sep. 8, 2014, which are expressly incorporated by reference herein.Fungicides are compounds, of natural or synthetic origin, which act to protect and/or cure plants against damage caused by agriculturally relevant fungi. Generally, no single fungicide is useful in all situations. Consequently, research is ongoing to produce fungicides that may have better performance, are easier to use, and cost less.The present disclosure relates to metalloenzyme inhibitors and their use as fungicides. The compounds of the present disclosure may offer protection against ascomycetes, basidiomycetes, deuteromycetes and oomycetes.One embodiment of the present disclosure may include compounds of Formula I:Where:Z is optionally substituted 5-pyrimidinyl, optionally substituted 4-pyrimidinyl, optionally substituted thiazolyl, optionally substituted oxazolyl, or optionally substituted 3-pyridinyl;Ris alkyl, haloalkyl, aryl, heteroaryl, each optionally substituted with 0,1,2 or 3 independent R;Ris aryl or heteroaryl each optionally substituted with 0,1,2 or 3 independent R;Ris independently H, alkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl, —C(O)alkyl, or —Si(alkyl), each optionally substituted with 0,1,2 or 3 independent R;R, R, R, and Rare independently H, alkyl, haloalkyl, alkoxy, halo, or cyano; andRis independently aryl, heteroaryl, alkyl, thioalkyl, cyano, haloalkyl, cyanoalkyl, hydroxy, alkoxy, halo, haloalkoxy, —C(O)alkyl, —C(O)OH, —C(O)O-alkyl, —SCF, —SF, —SCN, or —SO-alkyl.Another embodiment of the present disclosure may include a fungicidal composition for the control or prevention of fungal attack comprising the compounds ...

IDO/TDO Inhibitor

A compound of formula (I) given below or a pharmaceutically acceptable salt of the compound is useful as an IDO/TDO inhibitor. Thus, the compound of formula (I) or the pharmaceutically acceptable salt of the compound can be used as, for example, a therapeutic agent for a disease or a disorder selected from tumor, infectious disease, neurodegenerative disorder, cataract, organ transplant rejection, autoimmune disease, postoperative cognitive impairment, and disease related to women's reproductive health [in the following formula (I), ring A represents an aromatic ring, an aliphatic ring, a heterocyclic ring, or a condensed ring of two or more rings selected from an aromatic ring, an aliphatic ring and a heterocyclic ring; X, Rand Rrepresent a substituent on a ring atom constituting ring A; m represents an integer of 0 to 6; X represents, for example, a halogen atom; and Rand Rare the same or different and are selected from, for example, the group consisting of groups of formula (a) or formula (b); and in the following formula (a) and formula (b), Y is selected from the group consisting of O, S, and Se, Z is selected from the group consisting of O, S, and Se, n represents an integer of 1 to 8, r represents an integer of 1 to 8, s represents an integer of 1 to 8, Rrepresents, for example, —C(═NH)—HN, and Rrepresents, for example, a substituted or unsubstituted aryl group]. 4. The compound according to or a pharmaceutically acceptable salt of the compound claim 1 , wherein Rand Rare bonded to adjacent ring atoms of ring A.5. The compound according to or a pharmaceutically acceptable salt of the compound claim 1 , wherein Rand Rhave the same group.6. The compound according to or a pharmaceutically acceptable salt of the compound claim 5 , wherein in the compound of formula (I) claim 5 , Rand Rare a group represented by formula (II) claim 5 , and in formula (II) claim 5 , Rand Rare a hydrogen atom claim 5 , Y1 represents NR claim 5 , and r1 is 1.8. The compound according ...

Phenyl(oxy/thio)alkanol Derivatives

The present invention relates to novel phenyl(oxy/thio)alkanol derivatives, to processes for preparing these compounds, to compositions comprising these compounds and to their use as biologically active compounds, in particular for controlling harmful microorganisms in crop protection and in the protection of materials and as plant growth regulators. 2. The compound of formula (I) according to in which:X represents 5-pyrimidinyl, 1H-1,2,4-triazol-1-ylmethyl, 3-pyridinyl or 2,4-dihydro-3H-1,2,4-triazole-3-thion-1-ylmethyl,{'sub': '2', 'Y represents O, S or CH,'}Z represents bromine or iodine which is located in position 4, andR represents tert-butyl, isopropyl, 1-chlorocyclopropyl, 1-methylcyclopropyl, 1-methoxycyclopropyl or 1-methylthiocyclopropyl.6. A method for controlling phytopathogenic harmful fungi claim 1 , comprising applying a compound of formula (I) according to to the phytopathogenic harmful fungi claim 1 , their habitat or a combination thereof.7. A composition for controlling phytopathogenic harmful fungi claim 1 , comprising at least one compound of formula (I) according to claim 1 , and an extender claim 1 , a surfactant claim 1 , or a combination thereof.8. (canceled)9. A process for preparing a composition for controlling phytopathogenic harmful fungi claim 1 , comprising mixing a compound of formula (I) according to with an extender claim 1 , a surfactant claim 1 , or a combination thereof.16. A method for controlling phytopathogenic harmful fungi claim 2 , comprising applying a compound of formula (I) according to to the phytopathogenic harmful fungi claim 2 , their habitat or a combination thereof.17. A composition for controlling phytopathogenic harmful fungi claim 2 , comprising at least one compound of formula (I) according to claim 2 , and an extender claim 2 , a surfactant claim 2 , or a combination thereof.18. A process for preparing a composition for controlling phytopathogenic harmful fungi claim 2 , comprising mixing a compound of ...

METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES

The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes. 2. The compound according to wherein Ris methyl claim 1 , ethyl claim 1 , tert-butyl claim 1 , iso-propyl claim 1 , cyclopropyl claim 1 , trifluoromethyl claim 1 , 2 claim 1 ,4-difluorophenyl claim 1 , 2-fluoro-4-chlorophenyl claim 1 , —CF-(2 claim 1 ,4-difluorophenyl) claim 1 , —CF-(2-fluoro-4-chlorophenyl) claim 1 , —CH-(2 claim 1 ,4-difluorophenyl) claim 1 , or —CH-(2-fluoro-4-chlorophenyl)3. The compound according to wherein Z is optionally substituted 5-pyrimidinyl claim 1 , optionally substituted 4-pyrimidinyl claim 1 , or optionally substituted 3-pyridinyl.4. The compound according to wherein Z is 5-pyrimidinyl or 3-pyridinyl.5. The compound according to wherein Ris phenyl claim 1 , 2-pyridinyl claim 1 , 3-pyridinyl claim 1 , or 5-pyrimidinyl optionally substituted with 0 claim 1 , 1 claim 1 , 2 or 3 independent R.6. The compound according to wherein Ris halo claim 5 , haloalkyl claim 5 , cyanoalkyl claim 5 , haloalkoxy claim 5 , or cyano.7. The compound according to wherein Ris phenyl substituted at the 4 position with a halo claim 5 , haloalkyl claim 5 , cyanoalkyl claim 5 , haloalkoxy claim 5 , or cyano.8. The compound according to wherein Ris 2-pyridinyl substituted at the 5 position with a halo claim 5 , haloalkyl claim 5 , cyanoalkyl claim 5 , haloalkoxy claim 5 , or cyano.9. The compound according to wherein Ris 3-pyridinyl substituted at the 6 position with a halo claim 5 , haloalkyl claim 5 , cyanoalkyl claim 5 , haloalkoxy claim 5 , or cyano substituent.10. The compound according to wherein Rand Rare independently H claim 1 , CF claim 1 , methyl claim 1 , or halo.11. The compound according to wherein Rand Rare both H.12. The compound according to wherein Rand Rare both F.13. The compound according to wherein Rand Rare both Cl.14. The compound according to ...

METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES

The instant invention describes compounds of Formula I having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes. 118-. (canceled)21. The method according to claim 20 , wherein the disease or disorder is cancer claim 20 , cardiovascular disease claim 20 , endocrinologic disease claim 20 , inflammatory disease claim 20 , infectious disease claim 20 , gynecologic disease claim 20 , metabolic disease claim 20 , opthalmologic disease claim 20 , central nervous system (CNS) disease claim 20 , urologic disease claim 20 , or gastrointestinal disease.22. The method according to claim 20 , wherein the disease or disorder is systemic fungal infection claim 20 , mucosal infection claim 20 , or dermal infection.2332-. (canceled)34. The composition according to claim 33 , further comprising an additional therapeutic agent.35. The composition according to claim 33 , further comprising an additional therapeutic agent that is an anti-cancer agent claim 33 , antifungal agent claim 33 , cardiovascular agent claim 33 , antiinflammatory agent claim 33 , chemotherapeutic agent claim 33 , an anti-angiogenesis agent claim 33 , cytotoxic agent claim 33 , an anti-proliferation agent claim 33 , metabolic disease agent claim 33 , opthalmologic disease agent claim 33 , central nervous system (CNS) disease agent claim 33 , urologic disease agent claim 33 , or gastrointestinal disease agent.3639-. (canceled) This application claims the benefit of U.S. Provisional Patent Application Ser. Nos. 61/979,540 filed Apr. 15, 2014 and 62/047,384 filed Sep. 8, 2014, which are expressly incorporated by reference herein.Fungicides are compounds, of natural or synthetic origin, which act to protect and/or cure plants against damage couased by agriculturally relevant fungi. Generally, no single fungicide is useful in all situations. Consquently, research is ongoing to produce fungicides that may have better performance, are easier ...

SUBSTITUTED BICYCLIC COMPOUNDS

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): 116-. (canceled)19. The compound according to or a salt thereof claim 17 , wherein:{'sub': 2a', '2', '3', '3', '2', '5-6', '3', '2', '2', '3', '2', '2', '2', '3', '2', '3', '3', '2', '3', '3', '2', '2', '4', '2', '2', '4', '3', '2', '3', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '3', '2', '3', '2', '2', '2', '3', '3', '2', '1-3', '3', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '2', '2', '1-2', '3', '2', '2', '2', '2', '2', '2-3', '2', '2', '3-4', '3', '2', '2', '2', '3', '2', '2', '2', '2', '3', '3', '2', '2', '9', '3', '2', '2', '2', '2', '3', '2', '2', '2', '3', '2', '2', '3', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '3', '2', '3', '3', '2', '3', '3', '3', '3', '2', '1-6', '3', '3', '2', '2', '3', '2', '2', '3', '3', '3', '2', '2', '2', '3', '3', '2', '3', '2', '2', '2', '2', '2', '2', '3', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '3', '2', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '3', '2', '3', '2', '3', '2', '3', '2', '2', '2-4', '3', '2', '3', '2', '2', '2', '3', '2', '2', '2', '3', '3', '2', '2', '2', '3', '2', '2', '2', '2', '3', '3', '2', '2', '2', '3', '3', '2', '2', '2', '1-2', '3', '2', '2', '2', '3', '2', '2', '3', '3', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '3', '2', '2', '2', '3', '3', '2', '2', '2', '2', '4', '3', '2', '2', '4', '3', '3', '2', '4', '3', '2', '3', '2', '5', '3', '2', '2', '4-7', '3', '2', '2', '2', '2-4', '3', '2', '2', '2', '3', '2', '2', '2', '2-3', '3', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2-3', '3', ' ...

SUBSTITUTED BICYCLIC COMPOUNDS

Disclosed are compounds of Formulas (I), (II), (III), (IV), and (V): 116-. (canceled)19. The compound according to or a salt thereof claim 17 , wherein:{'sub': 2a', '2', '3', '3', '2', '5', '3', '2', '2', '3', '2', '2', '2', '3', '2', '3', '3', '2', '3', '3', '2', '2', '4', '2', '2', '4', '3', '2', '3', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '3', '2', '3', '2', '2', '2', '3', '3', '2', '1-3', '3', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '2', '2', '1-2', '3', '2', '2', '2', '2', '2', '2-3', '2', '2', '3-4', '3', '2', '2', '2', '3', '2', '2', '2', '2', '3', '3', '2', '2', '9', '3', '2', '2', '2', '2', '3', '2', '2', '2', '3', '2', '2', '3', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '3', '2', '2', '2', '2', '2', '3', '2', '3', '3', '2', '3', '3', '3', '3', '2', '1-6', '3', '3', '2', '2', '3', '2', '2', '3', '3', '3', '2', '2', '2', '3', '3', '2', '3', '2', '2', '2', '2', '2', '2', '3', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '3', '2', '3', '2', '3', '3', '2', '2', '3', '2', '2', '2', '2', '3', '2', '3', '2', '3', '2', '3', '2', '2', '2-4', '3', '2', '3', '2', '2', '2', '3', '2', '2', '2', '3', '3', '2', '2', '2', '3', '2', '2', '2', '2', '3', '3', '2', '2', '2', '3', '3', '2', '2', '2', '1-2', '3', '2', '2', '2', '3', '2', '2', '3', '3', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '3', '3', '2', '2', '2', '3', '3', '2', '2', '2', '2', '4', '3', '2', '2', '4', '3', '3', '2', '4', '3', '2', '3', '2', '5', '3', '2', '2', '4-7', '3', '2', '2', '2', '2-4', '3', '2', '2', '2', '3', '2', '2', '2', '2-3', '3', '2', '2', '2', '2', '2', '2', '2', '3', '2', '2', '2', '3', '2', '2', '2', '2', '2', '2', '2', '2', '2-3', '3', '2 ...

Odorless thiols for permanent waving, straightening and depilatory applications

Described herein is a chemical class of odorless thiols which can serve as reducing agents. This chemical class involves thiols which can be used as reducing agents for permanent styling treatments, depilatory compositions and other applications. The odorless thiols are thiols having a heterocyclic quaternary ammonium salt in their molecule.

12-EPI PLEUROMUTILINS

A compound selected from 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-sulfanyl)-acetyl]-12-epi-mutilins, or 14-O-[((Alkyl-, cycloalkyl-, heterocycloalkyl-, heteoroaryl-, or aryl)-oxy)-acetyl]-12-epi-mutilins, wherein 12-epi-mutilin is characterized in that the mutilin ring at position 12 is substituted by two substituents, the first substituent at position 12 of the mutilin ring is a methyl group which methyl group has the inverse stereochemistry compared with the stereochemistry of the methyl group at position 12 of the naturally occurring pleuromutilin ring, the second substituent at position 12 of the mutilin ring is a hydrocarbon group comprising at least one nitrogen atom and all other substituents of the mutilin ring having the same stereochemistry compared with the stereochemistry of the substituents at the corresponding positions in the naturally occurring pleuromutilin ring; optionally in the form of a salt and/or solvate, wherein the naturally occurring pleuromutilin is of formula 4. The compound according to claim 2 , wherein{'sub': '2', 'Ris'}{'sub': '1-16', '(C)alkyl,'}{'sub': '3-12', '(C)cycloalkyl,'}{'sub': '1-13', '(C)heterocyclyl,'}{'sub': '6-14', '(C)aryl,'}wherein heterocyclyl includes aliphatic and aromatic heterocyclyl comprising at least one heteroatom selected from N, O, S, and wherein alkyl, cycloalkyl, aryl, heterocyclyl is unsubstituted or substituted by substituents optionally having a heteroatom selected from O, N, S, and halogen.5. The compound according to claim 4 ,{'sub': '2', 'wherein Ris'}alkyl,optionally substituted byhydroxy or amino,{'sub': 3-12', '1-4', '1-6', '1-4, '(C)cycloalkyl wherein the cycloalkyl group is optionally further substituted by amino or amino(C)alkyl wherein the amino or aminoalkyl group is optionally further substituted by amino(C)alkylcarbonyl and optionally (C)alkyl,'}{'sub': 2-11', '1-6, '(C)heterocyclyl, wherein a nitrogen in the ring as a heteroatom optionally is further ...

Methods for the preparation of charged crosslinkers

Processes for the preparation of charged crosslinkers bearing a sulfonic acid moiety are disclosed. These procedures also optionally include methods to convert the resulting products to substantially a single salt form.

ORGANIC COMPOUNDS

A method of imparting to, or modifying in, a comestible product, umami taste, including the addition to a comestible product base of at least one compound of formula (I) 2. The method according to claim 1 , in which one of X claim 1 , X claim 1 , or Xis S and the remaining two are CH.3. The method according to claim 1 , in which Xis S claim 1 , and claim 1 , Xand Xare CH.4. The method according to claim 1 , in which Xis S claim 1 , and claim 1 , Xand Xare CH.7. The method according to claim 1 , in which the compound of formula (I) is selected from the group consisting of: 2-(2-(Phenylthio)ethyl)pyridine claim 1 , 2-(2-(Phenylthio)ethyl)pyridine hydrochloride claim 1 , Methyl 4-((2-(pyridin-2-yl)ethyl)thio) benzoate hydrochloride claim 1 , 2-(2-(p-tolylthio)ethyl)pyridine hydrochloride claim 1 , 2-(2-(o-tolylthio) ethyl)pyridine hydrochloride claim 1 , 4-((2-(pyridin-2-yl)ethyl)thio)phenol claim 1 , 2-((2-(pyridin-2-yl) ethyl)thio)phenol claim 1 , 2-(2-((3-methoxyphenyl)thio)ethyl)pyridine claim 1 , Methyl 2-((2-(pyridin-2-yl)ethyl)thio)benzoate hydrochloride claim 1 , 3-((2-(pyridin-2-yl)ethyl)thio)phenol claim 1 , 2-(2-(benzylthio)ethyl)pyridine claim 1 , 2-(2-(m-Tolylthio)ethyl)pyridine hydrochloride claim 1 , and 2-(2-((4-Methoxyphenyl)-thio)ethyl)pyridine hydrochloride.8. The method according to claim 1 , in which the compound of formula (I) is a salt.9. The method according to claim 8 , in which the compound of formula (I) is in the form of the hydrochloride salt. This disclosure relates to the use of compounds that can impart or modify umami taste in comestible products.Umami taste is an important flavour sensation. Accordingly, in the flavour industry there is a constant demand for compounds that impart or modify it.Such compounds extend a flavourist's palette and result in greater product diversity for consumers. Furthermore, such compounds may replace, or reduce reliance, on compounds conventionally used to impart or modify these tastes e.g. monosodium ...

FLAVOR MODULATOR HAVING PYRIDINE DERIVATIVE OR SALT THEREOF AS ACTIVE INGREDIENT

2-(phenylalkyloxyalkyl)pyridine derivative or a 2-(phenylalkylthioalkyl)pyridine derivative imparts, when added to food and drink or cosmetics as an active ingredient, a flavor of natural impression thereto; and in particular, when added to food and drink, the compound imparts an umami imparting or enhancing, a saltiness enhancing a sweetness enhancing, and in particular, when added to a milk or dairy product, a food or drink product containing a milk or dairy product, or a dairy replacement product, the compound provides a milk richness enhancing. 1. A compound represented by the following formula (4) or a salt thereof:wherein, in the formula (4), n=2, 3, 4 or 5, m=1 or 2, provided that a case where n=2 and m=1 is excluded, X represents 0 or S, and Y represents the following formula (5) or (6):wherein, in the above formula (5), Z represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms or a group OR, where R represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, provided that a case where n=3 or 4 and m=1, X is O and Z is H or a methyl group is excluded,{'sub': 1', '5', '1', '5, 'wherein, in the above formula (6), Rto Reach represent a hydrogen atom or a methyl group, and at least two of Rto Rare methyl groups.'} This application is a Continuation of PCT International Application No. PCT/JP2016/061077, filed Apr. 5, 2016, which claims priority under 35 U.S.C. Section 119(a) to Japanese Patent Application No. 2015-083656 filed on Apr. 15, 2015, Japanese Patent Application No. 2015-181420 filed on Sep. 15, 2015 and Japanese Patent Application No. 2015-206337 filed on Oct. 20, 2015. Each of the above applications is hereby expressly incorporated by reference, in its entirety, into the present application.The present invention relates to a flavor modulator having a pyridine derivative or a salt thereof as an active ingredient. More precisely, the present invention relates to a flavor composition for foods that uses the flavor modulator, ...

4-aminopicolinates and their use as herbicides

4-Aminopicolinic acids, having halogen, alkoxy, alkylthio, aryloxy, heteroaryloxy or trifluoromethyl substituents in the 3-, 5- and 6-positions, and their amine and acid derivatives of formula (I) wherein X represents H, halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, nitro, or trifluoromethyl; Y represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, heteroaryloxy or trifluoromethyl; Z represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy or nitro; and W represents -NO2, -N3, -NR1R2, -N=CR3R4 or -NHN=CR3R4 are potent herbicides demonstrating a broad spectrum of weed control.

含镍硅氢加成催化剂及含有该催化剂的组合物

本发明公开了一种组合物，所述组合物含有(A)硅氢加成反应催化剂和(B)脂族不饱和化合物，所述脂族不饱和化合物平均每分子具有一个或多个能够进行硅氢加成反应的脂族不饱和有机基团。所述组合物能够通过硅氢加成反应来反应而形成反应产物，如硅烷、树胶、凝胶、橡胶或树脂。成分(A)含有金属‑配体络合物，所述金属‑配体络合物可以通过包括使金属前体与配体反应的方法来制备。

Ruthenium containing hydrosilylation catalysts and compositions containing the catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition ' capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.

Iridium containing hydrosilylation catalysts and compositions containing the catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition ' capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.

PIRIDINES AND SUBSTITUTED BIPHENYLS

Las piridinas substituidas de formula (IA) se producen por reaccion de piridilaldehidos apropiadamente substituidos con reactivos de grignard o deWittig, y los productod resultantes se reducen en forma apropiada. Las piridinas deformul a (IA) son apropiadas como compuestos activos en losproductos farmacéuticos para la inhibicion de las proteínas de transferencia de éster de colesterol. Las piridinas 3-heteroalquilo-arilo-substituidas de laformula (IB) se producen a partirde piridi nas que están correspondientemente protegidas en el grupo hidroxi y que están correspondientemente substituidas.Los compuestos de la formula (IB) son apropiados como compuestos activos en los productos farmacéuticos, particularmente enlos producto s farmacéuticos para eltratamiento de hiperlipoproteinemia. Las piridinas y bencenos substituidos de la formula (IC) se producen mediante los procedimientos descriptos aquí y sonutiles como ingredientes activos en los productosfarmacéuticos para l a inhibicion del receptor de glucagon, destinados al tratamiento de los estadosintermediarios por glucagon tales como diabetes. The substituted pyridines of formula (IA) are produced by reaction of appropriately substituted pyridylaldehydes with grignard or deWittig reagents, and the resulting products are appropriately reduced. Deformul a (IA) pyridines are suitable as active compounds in pharmaceuticals for the inhibition of cholesterol ester transfer proteins. The 3-heteroalkyl-aryl-substituted pyridines of the formula (IB) are produced from pyridines that are correspondingly protected in the hydroxy group and that are correspondingly substituted. The compounds of formula (IB) are suitable as active compounds in the products pharmaceuticals, particularly in pharmaceuticals for the treatment of hyperlipoproteinemia. The formula (IC) substituted pyridines and benzenes are produced by the procedures described here and are useful as active ingredients in pharmaceuticals for glucagon receptor inhibition, ...

Metal containing hydrosilylation catalysts and compositions containing the catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.

Nickel containing hydrosilylation catalysts and compositions containing the catalysts

Iron containing hydrosilylation catalysts and compositions containing the catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.

N-hdroxy-2-(alkyl, aryl, or heteroaryl, sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors

Matrix metalloproteinases (MMPs) are a group of enzymes that have been implicated in the pathological destruction of connective tissue and basement membranes. These zinc containing endopeptidases consist of several subsets of enzymes including collagenases, stromelysins and gelatinases. TNF-α converting enzyme (TACE), a pro-inflammatory cytokine, catalyzes the formation of TNF-α from membrane bound TNF-α precursor protein. It is expected that small molecule inhibitors of MMPs and TACE therefore have the potential for treating a variety of disease states. The present invention provides low molecular weight, non-peptide inhibitors of matrix metalloproteinases (MMPs) and TNF-α converting enzyme (TACE) for the treatment of arthritis, tumor metastasis, tissue ulceration, abnormal wound healing, periodontal disease, bone disease, diabetes (insulin resistance) and HIV infection having the formula wherein R 2 and R 3 form a heterocyclic ring and A is S, S(O), or S(O) 2 , and R 1 and R 4 are defined herein.

Hafnium containing hydrosilylation catalysts and compositions containing the catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.

Analogos de cisteamina resistentes a la ado y sus usos.

La presente invención está dirigida a análogos de cisteamina resistentes a la ADO para usarse en métodos para tratar enfermedades para las cuales las cisteamida está indicada, en particular cistinosis, enfermedad de hígado graso, fibrosis, enfermedades trombóticas, trastornos relacionados con MECP-2, enfermedades hereditarias en las mitocondrias, enfermedades o trastornos neurológicos, inflamación y cáncer.

含铱硅氢加成催化剂及含有该催化剂的组合物

本发明公开了一种组合物，所述组合物含有(A)硅氢加成反应催化剂和(B)脂族不饱和化合物，所述脂族不饱和化合物平均每分子具有一个或多个能够进行硅氢加成反应的脂族不饱和有机基团。所述组合物能够通过硅氢加成反应来反应而形成反应产物，如硅烷、树胶、凝胶、橡胶或树脂。成分(A)含有金属-配体络合物，所述金属-配体络合物可以通过包括使金属前体与配体反应的方法来制备。

含钴硅氢加成催化剂及含有该催化剂的组合物

本发明公开了一种组合物，所述组合物含有(A)硅氢加成反应催化剂和(B)脂族不饱和化合物，所述脂族不饱和化合物平均每分子具有一个或多个能够进行硅氢加成反应的脂族不饱和有机基团。所述组合物能够通过硅氢加成反应来反应而形成反应产物，如硅烷、树胶、凝胶、橡胶或树脂。成分(A)含有金属-配体络合物，所述金属-配体络合物可以通过包括使金属前体与配体反应的方法来制备。

Platinum complex dioxygen sensors

The luminescent platinum 1,2-enedithiolates are dual emitters with a short-lived 1 ILCT* singlet and long-lived oxygen-sensing 3 ILCT* triplet (ILCT; intraligand charge transfer transition) emissive excited states. Since only the triplet is quenched by molecular oxygen, the singlet serves as an internal standard for dioxygen measurements. This allows the concentration of dioxygen to be determined from the ratio of the singlet/triplet emissions. The novel dual emitters are readily polymer encapsulated to allow measurement of dioxygen in a range of settings. These polymer encapsulated dual emitters will serve as a drop-in step-out replacement sensor for currently available dioxygen measuring devices.

The method of obtaining derivatives of pyridinecarbamate

Functionalized polymers using protected thiols

A process for the preparation of functional molecules using the thiol-ene coupling reaction and a process for the preparation of protected functional thiols, specifically thioesters is provided. The methods may be used to make functional polymers and other molecules. The method of making a functionalized polymer using a thiol-ene reaction comprises: providing a functionalized thioester having the following formula: (I) wherein R is a functional group and COR' is a protecting group; cleaving the functionalized thioester, forming a functional thiol and an acyl group; providing a polymer having a pendant vinyl group; and reacting the polymer with the functional thiol whereby a functionalized polymer is formed, wherein the functional thiol is not isolated prior to reacting with the polymer.

Способ получени производных 1,1-диаминоэтилена

Method for protection of vegetative plants of sugar beet against damaging action of herbicides

FIELD: agriculture.SUBSTANCE: invention relates to the agriculture. Method for protection of vegetative plants of sugar beet from damaging effect of herbicides envisages introduction of 2-benzylsulfanyl-4,6-dimethyl-5-R-nicotinonitrile in amount of 40 g/ha into a tank mixture of herbicides.EFFECT: invention makes it possible to increase the yield of sugar beet.1 cl, 1 tbl, 4 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) (19) RU (51) МПК A01N 31/06 A01N 33/06 A01N 37/34 A01N 43/40 C07D 213/26 C07D 213/32 C07D 213/54 (11) (13) 2 707 547 C1 (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) (2006.01) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A01N 31/06 (2019.08); A01N 33/06 (2019.08); A01N 37/34 (2019.08); A01N 43/40 (2019.08); C07D 213/26 (2019.08); C07D 213/32 (2019.08); C07D 213/54 (2019.08) (21)(22) Заявка: 2019113969, 06.05.2019 06.05.2019 27.11.2019 Приоритет(ы): (22) Дата подачи заявки: 06.05.2019 (45) Опубликовано: 27.11.2019 Бюл. № 33 R U 2 7 0 7 5 4 7 (54) Способ защиты вегетирующих растений сахарной свеклы от повреждающего действия гербицидов (57) Реферат: Изобретение относится к сельскому хозяйству. гербицидов 2-бензилсульфанил-4,6-диметил-5-RСпособ защиты вегетирующих растений сахарной никотинонитрила в количестве 40 г/га. свеклы от повреждающего действия гербицидов Изобретение позволяет повысить урожайность предусматривает введение в баковую смесь сахарной свеклы. 1 табл., 4 пр. Стр.: 1 C 1 C 1 Адрес для переписки: 350039, г.Краснодар, п/о 39, ФГБНУ ВНИИБЗР, ВРИО директора Асатуровой А.М. (56) Список документов, цитированных в отчете о поиске: RU 2404582 C1, 27.11.2010. RU 2577106 C2, 10.03.2016. US 20100279863 A1, 04.11.2010. 2 7 0 7 5 4 7 (73) Патентообладатель(и): Федеральное государственное бюджетное научное учреждение "Всероссийский научно-исследовательский институт биологической защиты растений" (RU) Дата регистрации: R U (24) Дата начала отсчета срока действия патента: (72) Автор(ы): Дядюченко Людмила ...

Iridium containing hydrosilylation catalysts and compositions containing the catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.

Ruthenium containing hydrosilylation catalysts and compositions containing the catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.

Nickel containing hydrosilylation catalysts and compositions containing the catalysts

A composition contains (A) a hydrosilylation reaction catalyst and (B) an aliphatically unsaturated compound having an average, per molecule, of one or more aliphatically unsaturated organic groups capable of undergoing hydrosilylation reaction. The composition is capable of reacting via hydrosilylation reaction to form a reaction product, such as a silane, a gum, a gel, a rubber, or a resin. Ingredient (A) contains a metal-ligand complex that can be prepared by a method including reacting a metal precursor and a ligand.

Process for producing 2-4-pyridylethanethiol

본 발명의 목적은 2-(4-피리딜)에탄티올을 쉽게 제조하는 방법을 제공하는 것이다. It is an object of the present invention to provide a method for easily preparing 2- (4-pyridyl) ethanethiol. 본 발명에 따르면, 산을 함유하는 수성 매질에서 4-비닐피리딘을 티오요소와 반응시켜 이소티우로늄 염을 함유하는 용액을 형성한 후, 그 용액을 알칼리성으로 만들어 이소티우로늄 염을 2-(4-피리딜)에탄티올로 전환시킨다. According to the present invention, 4-vinylpyridine is reacted with thiourea in an aqueous medium containing an acid to form a solution containing an isothiuronium salt, and then the solution is made alkaline to make the isotyuronium salt 2- Convert to (4-pyridyl) ethanethiol.

Cysteamine dioxygenase-resistant analogues of cysteamine and their use

FIELD: medicine. SUBSTANCE: invention relates to a method for the treatment of patient suffering from a disease, at which the treatment with cysteamine is prescribed, wherein the disease is a neurological disease or disorder. The method includes the injection to the patient of the effective amount of a composition containing a compound of the formula I or its disulfide, which has a structure selected from the following. In the formulas, R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are independently selected from a group consisting of H and C 1-5 alkyl. The invention also relates to compounds of the first of the specified formulas, where R 1 is C 1-5 alkyl, and R 3 , R 4 , R 5 , R 7 and R 8 are H, which are used in this method. EFFECT: proposed method allows for the reduction in cystine levels in patients. and 6 cl, 1 dwg, 7 tbl, 7 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) (19) RU (11) (13) 2 766 579 C2 (51) МПК A61K 31/145 (2006.01) A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61K 31/4402 (2006.01) A61K 31/4409 (2006.01) A61K 31/4465 (2006.01) C07D 211/54 (2006.01) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК A61K 31/145 (2020.02); A61K 31/397 (2020.02); A61K 31/40 (2020.02); A61K 31/4402 (2020.02); A61K 31/4409 (2020.02); C07D 211/54 (2020.02) (21)(22) Заявка: 2018103901, 01.07.2016 01.07.2016 Дата регистрации: 15.03.2022 02.07.2015 US 62/187,939; 23.12.2015 US 62/387,337 (43) Дата публикации заявки: 05.08.2019 Бюл. № 22 (45) Опубликовано: 15.03.2022 Бюл. № 8 (86) Заявка PCT: US 2016/040637 (01.07.2016) R U 2 7 6 6 5 7 9 (87) Публикация заявки PCT: WO 2017/004485 (05.01.2017) Адрес для переписки: 129090, Москва, ул. Б.Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" (54) ЦИСТЕАМИНДИОКСИГЕНАЗА-РЕЗИСТЕНТНЫЕ АНАЛОГИ ЦИСТЕАМИНА И ИХ ПРИМЕНЕНИЕ (57) Реферат: Изобретение относится к способу лечения R2, R3, R4, R5, R6, R7 и R8 независимо выбраны из пациента, страдающего заболеванием, при группы, состоящей из H и ...

Bisaryl compounds and cancer remedies containing the same

Cancer remedies, each containing a compound of the following general formula (I): Ar?1-S-R1-S-Ar2¿ [wherein RP represents a non-metallic connecting group; Ar?1 and Ar2¿ each independently represents aryl or heteroaryl having 1 to 3 hydroxyls which may be substituted with a monovalent group on the ring thereof (and optionally having 1 to 3 substituents other than the hydroxyl on the ring thereof)] or a physiologically acceptable salt thereof; and compounds of the following general formula (XII): Ar?23-S-R22-N(R24)-R23-S-Ar24¿ [wherein R?22 and R23¿ each independently represents a divalent group; R24 represents a monovalent group or atom, or R24 may be bonded to R22 and/or R23 to form a cyclic structure and further bonded to one or two C¿1-4? alkylene groups to form a divalent group; and Ar?23 and Ar24¿ each independently represents aryl or heteroaryl (optionally having 1 to 3 substituents other than hydroxyl on the ring thereof) having 1 to 3 hydroxyls which may be substituted with a monovalent group; excluding specified compounds] and salts thereof.

Methods for preparing bridged bi-aromatic ligands

Bisaryl compound and medicament for cancer treatment comprising the same

A medicament for treatment of cancer comprising a compound represented by the following general formula (I) or a physiologically acceptable salt thereof: Ar 1 —S—R 1 —S—Ar 2 wherein R 1 represents a nonmetal bridging group; Ar 1 and Ar 2 independently represent a group selected from the group consisting of an aryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group and said aryl group may have one to three substituents other than hydroxyl group on its ring; and a heteroaryl group which has, on its ring, one to three hydroxyl groups optionally substituted with a monovalent group, and said heteroaryl group may have one to three substituents other than hydroxyl group on its ring.

4-Aminopicolinates and herbicidal compositions comprising the same

본 발명은 넓은 잡초 방제 스펙트럼을 나타내는 강력한 제초제인, 3, 5 및 6위치에 할로겐, 알콕시, 알킬티오, 아릴옥시, 헤테로아릴옥시 또는 트리플루오로메틸 치환체를 갖는 화학식 I의 4-아미노피콜린산과, 이의 아민 및 산 유도체에 관한 것이다. 화학식 I 위의 화학식 I에서, X는 H, 할로겐, C 1 -C 6 알콕시, C 1 -C 6 알킬티오, 아릴옥시, 니트로 또는 트리플루오로메틸이고, Y는 할로겐, C 1 -C 6 알콕시, C 1 -C 6 알킬티오, 아릴옥시, 헤테로아릴옥시 또는 트리플루오로메틸이고, Z는 할로겐, C 1 -C 6 알콕시, C 1 -C 6 알킬티오, 아릴옥시 또는 니트로이고, W는 -NO 2 , -N 3 , -NR 1 R 2 , -N=CR 3 R 4 또는 -NHN=CR 3 R 4 이다. 제초제, 잡초, 아미노피콜리네이트, 아민, 방제

A PROCEDURE FOR PREPARING NEW CEFEM COMPOUNDS

Fluorinated oxa or thia heteroarylalkylsulfide derivatives for combating invertebrate pests

The invention relates to alkylsulfide derivatives compounds of formula I as hererunder depicted or the enantiomers or veterinarily acceptable salts thereof which are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to methods for controlling invertebrate pests by using these compounds and to plant propagation material and to agricultural and veterinary compositions comprising said compounds. wherein U, R1, R2, R3U, X, n and p are defined as in the description.

Phenyl(oxy/thio)alkanol derivatives

The present invention relates to novel phenyl(oxy/thio)alkanol derivatives, to methods for producing said compounds, to agents containing said compounds, and to the use thereof as biologically active compounds, in particular for controlling harmful microorganisms in plant protection and in material protection and as plant growth regulators.

Method of preparing guanidine derivative

CYSTEAMINDIOXYGENASE-RESISTANT CYSTEAMIN ANALOGUES AND THEIR USE

РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2022 103 033 A (51) МПК A61K 31/145 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ЗАЯВКА НА ИЗОБРЕТЕНИЕ (21)(22) Заявка: 2022103033, 01.07.2016 (71) Заявитель(и): ХОРАЙЗОН ОРФАН ЭлЭлСи (US) Приоритет(ы): (30) Конвенционный приоритет: (72) Автор(ы): ЗАНКЕЛ, Тодд, К. (US), ЮНИТТ, Джон (GB), ФИЛЛИПС, Тимоти (GB), ГУРДЭ, Бенуа (GB), ДАФФИ, Лома (GB) R U 02.07.2015 US 62/187,939; 23.12.2015 US 62/387,337 (62) Номер и дата подачи первоначальной заявки, из которой данная заявка выделена: 2018103901 01.02.2018 (43) Дата публикации заявки: 01.04.2022 Бюл. № 10 R U (57) Формула изобретения 1. Способ лечения пациента, страдающего заболеванием, при котором показано лечение цистеамином, включающий введение пациенту эффективного количества композиции, содержащей соединение формулы I или его дисульфид: A 2 0 2 2 1 0 3 0 3 3 A (54) ЦИСТЕАМИНДИОКСИГЕНАЗА-РЕЗИСТЕНТНЫЕ АНАЛОГИ ЦИСТЕАМИНА И ИХ ПРИМЕНЕНИЕ 2 0 2 2 1 0 3 0 3 3 Адрес для переписки: 129090, Москва, ул. Б.Спасская, 25, строение 3, ООО "Юридическая фирма Городисский и Партнеры" где R1 и R2 независимо выбраны из группы, состоящей из H и C1-5-алкила; или R1 и R2, взятые вместе с атомом углерода, к которому они присоединены, образуют 3-, 4-, 5-, 6-, 7- или 8-членное карбоциклическое кольцо; R3 и R4 независимо выбраны из группы, состоящей из H и C1-5-алкила; или R3 и R4, взятые вместе с атомом углерода, к которому они присоединены, образуют 3-, 4-, 5-, 6-, 7- или 8-членное карбоциклическое кольцо; G выбран из группы, состоящей из -NR5R6 и -CR7R8NR5R6; R5 и R6 независимо выбраны из группы, состоящей из H и C1-5-алкила; или R5 и R6, взятые вместе с атомом азота, к которому они присоединены, образуют 3-, 4-, 5-, 6-, 7- или 8-членное гетероциклическое кольцо; Стр.: 1 R7 и R8 независимо выбраны из группы, состоящей из H и C1-5-алкила; или R7 и R8, взятые вместе с атомом углерода, к которому они присоединены, образуют 3-, 4-, 5-, 6-, 7- или 8-членное карбоциклическое кольцо; ...

Method of obtaining bis-(2-methyl-3-oxy-5-vinylpyridyl-4-methyl) disulfide or salts thereof

Phenyl derivatives as ppar agonists

FIELD: chemistry. SUBSTANCE: invention relates to compounds of formula and to their pharmaceutically acceptable salts or esters, where X 1 is O, S, CH 2 ; R 1 is hydrogen; R 2 is hydrogen or C 1 -C 7 alkyl, R 3 is hydrogen or C 1 -C 7 alkyl; R 4 and R 8 are independently hydrogen, C 1 -C 7 alkyl, C 1 -C 7 alkoxy-C 1 -C 7 alkyl, fluoroC 1 -C 7 alkyl; R 5 , R 6 and R 7 are independently hydrogen, C 1 -C 7 alkyl, halogen, fluoroC 1 -C 7 alkyl; and one or R 5 , R 6 and R 7 represents , where X 2 is S, O, NR 9 , (CH 2 ) P NR 9 CO or (CH 2 ) P CONR 9 , R 9 is hydrogen, C 1 -C 7 alkyl; one or two of Y 1 , Y 2 , Y 3 and Y 4 is N, and the rest represent C-R 12 R 10 is C 1 -C 7 alkyl, C 3 -C 7 cycloalkyl; R 11 is hydrogen; R 12 in each case is independently selected from hydrogen, C 1 -C 7 alkyl, C 3 -C 7 cycloalkyl, fluoroC 1 -C 7 alkyl, C 1 -C 7 alkoxy-C 1 -C 7 alkyl, hydroxyC 1 -C 7 alkyl, di-C 1 -C 7 alkylamino-C 1 -C 7 alkyl; R 13 is phenyl or heteroaryl, which is a 6-member aromatic ring, containing nitrogen as a heteroatom, which can be substituted with a CF 3 group, lower fluroalkoxy group or halogen; m=0 or 1, n=0, 1, 2, and p=0, 1 or 2, and the sum of m, n and p=1, 2, 3 or 4; under the condition that, there are no formula I compounds, where X 1 is O, R 2 and R 3 are hydrogen; R 6 is , X 2 is O or S, and m=0. The invention also relates to pharmaceutical compositions containing such compounds, with agonistic activity towards PPARδ and/or PPARα. EFFECT: obtaining compounds for pharmaceutical compositions, with agonistic activity towards PPARδ and/or PPARα. 28 cl, 155 ex (19) РОССИЙСКАЯ ФЕДЕРАЦИЯ RU (11) 2 374 230 (13) C2 (51) МПК C07D C07D C07D C07D C07D C07D C07D ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ,C07D C07D ПАТЕНТАМ И ТОВАРНЫМ ЗНАКАМ C07D (12) ОПИСАНИЕ 213/38 213/30 213/32 213/46 213/56 213/75 213/82 237/08 239/26 239/28 (43) Дата публикации заявки: 27.12.2007 (73) Патентообладатель(и): Ф.ХОФФМАНН-ЛЯ РОШ АГ (CH) (85) Дата перевода заявки PCT на ...

Patent RU2018103901A3

`”ВУ“” 2018103901” АЗ Дата публикации: 25.05.2020 Форма № 18 ИЗПМ-2011 Федеральная служба по интеллектуальной собственности Федеральное государственное бюджетное учреждение 5 «Федеральный институт промышленной собственности» (ФИПС) ОТЧЕТ О ПОИСКЕ 1. . ИДЕНТИФИКАЦИЯ ЗАЯВКИ Регистрационный номер Дата подачи 2018103901/04(005684) 01.07.2016 РСТ/О$2016/040637 01.07.2016 Приоритет установлен по дате: [ ] подачи заявки [ ] поступления дополнительных материалов от к ранее поданной заявке № [ ] приоритета по первоначальной заявке № из которой данная заявка выделена [ ] подачи первоначальной заявки № из которой данная заявка выделена [ ] подачи ранее поданной заявки № [Х] подачи первой(ых) заявки(ок) в государстве-участнике Парижской конвенции (31) Номер первой(ых) заявки(ок) (32) Дата подачи первой(ых) заявки(ок) (33) Код страны 1. 62/187,939 02.07.2015 05 2. 62/387,337 23.12.2015 05 Название изобретения (полезной модели): [Х] - как заявлено; [ ] - уточненное (см. Примечания) ЦИСТЕАМИНДИОКСИГЕНАЗА-РЕЗИСТЕНТНЫЕ АНАЛОГИ ЦИСТЕАМИНА И ИХ ПРИМЕНЕНИЕ Заявитель: ХОРАЙЗОН ОРФАН ЭлЭлСи, 0$ 2. ЕДИНСТВО ИЗОБРЕТЕНИЯ [Х] соблюдено [ ] не соблюдено. Пояснения: см. Примечания 3. ФОРМУЛА ИЗОБРЕТЕНИЯ: [Х] приняты во внимание все пункты см. п см. Примечания [ ] приняты во внимание следующие пункты: [ ] принята во внимание измененная формула изобретения (см. Примечания) 4. КЛАССИФИКАЦИЯ ОБЪЕКТА ИЗОБРЕТЕНИЯ (ПОЛЕЗНОЙ МОДЕЛИ) (Указываются индексы МПК и индикатор текущей версии) Аб1К 31/145 (2006.01) 5. ОБЛАСТЬ ПОИСКА 5.1 Проверенный минимум документации РСТ (указывается индексами МПК) Аб1К 31/145, Аб1К 31/397, Аб1К 31/40, Аб1К 31/4402, Аб1К 31/4409, Аб1ТК 31/4465, С07О 211/54 5.2 Другая проверенная документация в той мере, в какой она включена в поисковые подборки: 5.3 Электронные базы данных, использованные при поиске (название базы, и если, возможно, поисковые термины): РУ\У/Р1, ЕАРАТТ$, Езрасепе боозе Раепз, РАТЕМТСОРЕ, РабеагсЬ, РиБСвет, Кеахуз, Уапдех 6. ДОКУМЕНТЫ, ОТНОСЯЩИЕСЯ К ПРЕДМЕТУ ...

Pesticide

Method of preparation of heterocyclic compositions

4-AMYNOPYCHOLINATES AND ITS USE AS HERBICIDES.

Un compuesto de **Fórmula**, en la que: Y representa: halógeno, alcoxi C1-C6, alquil(C1-C6)tio, ariloxi, heteroariloxi o trifluorometilo; Z representa: halógeno, alcoxi C1-C6, alquil(C1-C6)tio, ariloxi o nitro y W representa: -N3, -NR1R2, -N=CR3R4 o -NHN=CR3R4 A compound of ** Formula **, in which: Y represents: halogen, C1-C6 alkoxy, (C1-C6) alkylthio, aryloxy, heteroaryloxy or trifluoromethyl; Z represents: halogen, C1-C6 alkoxy, (C1-C6) alkyl thio, aryloxy or nitro and W represents: -N3, -NR1R2, -N = CR3R4 or -NHN = CR3R4

4-Aminopicolinates and their use as herbicides

4-AMINOPICOLINATE AND ITS USE AS HERBICIDES

4-aminopicolinates and their use as herbicides

4-aminopicolinates and their use as herbicides

4-Aminopicolinic acids, having halogen, alkoxy, alkylthio, aryloxy, heteroaryloxy or trifluoromethyl substituents in the 3-, 5- and 6-positions, and their amine and acid derivatives of formula (I) wherein X represents H, halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, nitro, or trifluoromethyl; Y represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, heteroaryloxy or trifluo-romethyl; Z represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy or nitro; and W represents -NO2, -N3, -NR1R2, -N=CR3R4 or -NHN=CR3R4 are potent herbicides demonstrating a broad spectrum of weed control.

4-Aminopicolinates and their APPLICATION as herbicides

4-Aminopicolinic acids, having halogen, alkoxy, alkylthio, aryloxy, heteroaryloxy or trifluoromethyl substituents in the 3-, 5- and 6-positions, and their amine and acid derivatives of formula (I) wherein X represents H, halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, nitro, or trifluoromethyl; Y represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, heteroaryloxy or trifluoromethyl; Z represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy or nitro; and W represents -NO2, -N3, -NR1R2, -N=CR3R4 or -NHN=CR3R4 are potent herbicides demonstrating a broad spectrum of weed control. , (I)

4-aminopicolinates and their use as herbicides

4-aminopicolinates and their derivatives can be used as herbicides

4-Aminopicolinic acids, having halogen, alkoxy, alkylthio, aryloxy, heteroaryloxy or trifluoromethyl substituents in the 3-, 5- and 6-positions, and their amine and agriculturally acceptable derivatives of the carboxylic acid of formula (I) that are potent herbicides demonstrating a broad spectrum of weed control are disclosed, wherein: X represents H, halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, nitro, or trifluoromethyl; Y represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, heteroaryloxy or trifluoromethyl; Z represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy or nitro; and W represents -NO2, -N3, -NR1R2, -N=CR3R4 or -NHN=CR3R4; wherein R1 and R2 independently represent H, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, aryl, heteroaryl, hydroxy, C1-C6 alkoxy, amino, C1-C6 acyl, C1-C6 carboalkoxy, C1-C6 alkylcarbamyl, C1-C6 alkylsulfonyl, C1-C6 trialkylsilyl or C1-C6 dialkyl phosphonyl or R1 and R2 taken together with N represent a 5- or 6-membered saturated or unsaturated ring which may contain additional O, S or N heteroatoms ; and R3 and R4 independently represent H, C1-C6 alkyl, C3-C6 alkenyl, C3-C6 alkynyl, aryl or heteroaryl or R3 & R4 taken together with =C represent a 5- or 6-membered saturated ring ; with the proviso that when X represents H or Cl, then Y and Z are not both Cl, or when X and Z both represent Cl, then Y is not Br.

4−aminopicolinates and their use as herbicides

4-Aminopicolinic acids, having halogen, alkoxy, alkylthio, aryloxy, heteroaryloxy or trifluormethyl substituents in the 3-, 5- and 6-positions, and their amine and acid derivatives of formula (I) wherein X represents H, halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, nitro, or trifluoromethyl; Y represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, heteroaryloxy or trifluoromethyl; Z represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy or nitro; and W represents -NO2, -N3, -NR1R2, -N=CR3R4 or -NHN=CR3R4 are potent herbiciedes demonstrating a broad spectrum of weed control.

4-aminopicolinates and their use as herbicides

4-AMINOPICOLINATES, HERBICIDAL COMPOSITION COMPRISING THEM AND METHOD OF CONTROLLING UNDESIRABLE VEGETATION

4-AMINOPI-COLINATOS, COMPOSIÇÃO HERBICIDA COMPREENDENDO OS MESMOS E MÉTODO DE CONTROLAR VEGETAÇÃO INDESEJÁVEL. A presente invenção se refere a ácidos 4-aminopicolínico, tendo substituintes de halogênio, alcóxi, alquiltio, arilóxi, heteroarilóxi ou trifluorometila nas posições 3, 5 e 6, e seus derivados de amina e ácido de fórmula (I) onde X representa H, halogênio, C~ 1~-C~ 6~ alcóxi, C~ 1~-C~ 6~ alquiltio, arilóxi, nitro ou trifluorometila; Y representa halogênio, C~ 1~-C~ 6~ alcóxi, C~ 1~-C~ 6~ alquiltio, arilóxi, heteroarilóxi ou trifluorometila; Z representa halogênio, C~ 1~-C~ 6~ alcóxi, C~ 1~-C~ 6~ alquiltio, arilóxi ou nitro; e W representa -NO~ 2~, -N~ 3~, -NR~ 1~R~ 2~, -N = CR~ 3~R~ 4~ ou - NHN = CR~ 3~R~ 4~ são herbicidas demonstrando um amplo espectro de controle de erva daninha. Ademais, a presente invenção se refere a uma composição herbicida compreendendo uma quantidade herbicidamente eficaz do referido composto e um adjuvante ou veículo agricolamente aceitável; e um método de controlar vegetação indesejável compreendendo colocar em contato a vegetação ou ao local desta com ou aplicando-se ao solo para prevenir a emergência de vegetação, uma quantidade herbicidamente eficaz da referida composição herbicida. 4-AMINOPI-CHOLINATES, HERBICIDAL COMPOSITION COMPRISING THEM AND METHOD OF CONTROLLING UNDESIRABLE VEGETATION. The present invention relates to 4-aminopicolinic acids having halogen, alkoxy, alkylthio, aryloxy, heteroaryloxy or trifluoromethyl substituents at positions 3, 5 and 6, and their amine and acid derivatives of formula (I) where X represents H, halogen, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, aryloxy, nitro or trifluoromethyl; Y represents halogen, C 1 -C 6 -alkoxy, C 1 -C 6 -alkylthio, aryloxy, heteroaryloxy or trifluoromethyl; Z represents halogen, C 1 -C 6 - alkoxy, C 1 -C 6 - alkylthio, aryloxy or nitro; and W represents -NO~ 2~, -N~ 3~, -NR~ 1~R~ 2~, -N = CR~ 3~R~ 4~ or -NHN = CR~ 3~R~ 4~ are herbicides demonstrating a broad spectrum of ...

4-aminopicolinates and their use as herbicides

4-Aminopicolinic acids, having halogen, alkoxy, alkylthio, aryloxy, heteroaryloxy or trifluoromethyl substituents in the 3-, 5- and 6-positions, and their amine and acid derivatives of formula (I) wherein X represents H, halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, nitro, or trifluoromethyl; Y represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, heteroaryloxy or trifluoromethyl; Z represents halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy or nitro; and W represents -NO2, -N3, -NR1R2, -N=CR3R4 or -NHN=CR3R4 are potent herbicides demonstrating a broad spectrum of weed control.

4-aminopicolinates and their use as herbicides

4-Aminopicolinates and their use as herbicides

4-AMYNOPYCHOLINATES AND ITS USE AS HERBICIDES

LA PRESENTE INVENCIÓN ES SOBRE ÁCIDOS 4-AMINOPICOLINICOS QUE TIENE SUBTITUYENTES DE TRIFLUOROMETILO, HETEROARILOXI, ARILLOXI O HÁLOGENO EN LAS POSICIONES 3, 5 Y 6, Y SUS DERIVADOS DE ÁCIDO Y AMINA DE LA FÓRMULA (I).-

4-Aminopicolinates and their use as herbicides

4-aminopicolinates and their use as herbicides

在3-，5-和6-位有卤素，烷氧基，烷基硫，芳氧基，杂芳氧基或三氟甲基取代基的4-氨基吡啶甲酸，和结构式I的胺和酸衍生物(其中，X表示H，卤素，C 1 -C 6 的烷氧基，C 1 -C 6 的烷基硫，芳氧基，硝基或三氟甲基；Y表示卤素，C 1 -C 6 的烷氧基，C 1 -C 6 的烷基硫，芳氧基，杂芳氧基或三氟甲基；Z表示卤素，C 1 -C 6 烷氧基，C 1 -C 6 烷基硫，芳氧基或硝基；和W表示-NO 2 ，-N 3 ，-NR 1 R 2 ，-N＝CR 3 R 4 或-NHN＝CR 3 R 4 ，)是有潜力的具有广谱杂草控制范围的除草剂。

4-AMYNOPYCHOLINATES AND ITS USE AS HERBICIDES

Acidos 4-aminopicolínicos, que tienen halogeno, alcoxi, alquiltio, ariloxi, heteroariloxi o sustituyentes de trifluorometilo en las posiciones 3-, 5- y 6-,y sus aminas y derivados de ácido que son potentes herbicidas que demuestran un espectro amplio de control de malezas. 4-Aminopicolinic acids, which have halogen, alkoxy, alkylthio, aryloxy, heteroaryloxy or trifluoromethyl substituents at positions 3-, 5- and 6-, and their amines and acid derivatives that are potent herbicides that demonstrate a broad spectrum of control weed.

4-AMYNOPYCHOLINATES AND ITS USE AS HERBICIDES

Un compuesto de la fórmula I:<EMI FILE="01002407_1" ID="1" IMF=JPEG >En dondeX representa H, halógeno, alcoxi C1-C6, alquiltio C1-C6, ariloxi, nitro o trifluorometilo; Y representa halógeno, alcoxi C1-C6 alquiltio, ariloxi, heteroariloxi, o trifluorometilo;Z representa halógeno, alcoxi C1-C6, alquiltio, C1-C6 ariloxi o nitro;W representa -NO2, -N3, -NR1R2, -N=CR3R4 o -NHN=CR3R4DondeR1 y R2 independientemente representan H, alquilo, C1-C6 alquilo C3-C6, alquinilo C3-C6, arilo, heteroarilo, hidroxi, alcoxi C1-C6, amino, acilo C1-C6, carboalcoxi C1-C6, alquilcarbamilo C1-C6, alquilsulfonilo C1-C6, trialquisililo C1-C6 o dialquilfosfonilo C1-C6 o R1 y R2 tomados juntos con N representan un anillo saturado o insaturado de 5 o 6 miembros que puede contener heteroátomos O, S o N adicionalmente;R3 y R4 independientemente representa H, alquilo C1-C6, alquenilo C3-C6, alquinilo C3-C6, arilo o heteroarilo o R3 o R4 tomados juntos con = C representan un anillo saturado de 5 o 6 miembros; yLos derivados agrícolamente aceptables del ácido carboxílico, con la condición de que cuando X representa CL, entonces Y y Z no son ambos CL. A compound of the formula I: <EMI FILE = "01002407_1" ID = "1" MFI = JPEG> Where X represents H, halogen, C1-C6 alkoxy, C1-C6 alkylthio, aryloxy, nitro or trifluoromethyl; Y represents halogen, C1-C6 alkylthio, aryloxy, heteroaryloxy, or trifluoromethyl; Z represents halogen, C1-C6 alkoxy, alkylthio, C1-C6 aryloxy or nitro; W represents -NO2, -N3, -NR1R2, -N = CR3R4 or -NHN = CR3R4 Where R1 and R2 independently represent H, alkyl, C1-C6 C3-C6 alkyl, C3-C6 alkynyl, aryl, heteroaryl, hydroxy, C1-C6 alkoxy, amino, C1-C6 acyl, C1-C6 carboalkoxy, alkylcarbamyl C1-C6, C1-C6 alkylsulfonyl, C1-C6 trialkylsilyl or C1-C6 dialkylphosphonyl taken together with N represent a saturated or unsaturated 5 or 6 membered ring which may additionally contain heteroatoms O, S or N; R3 and R4 independently represents H, C1-C6 alkyl, ...

4-AMYNOPICOLINATES AND ITS USE AS HERBICIDES

Acidos 4-aminopicolinicos, que tienen substituyentes de trifluorometilo, heteroariloxi, ariloxi, alquiltio, alcoxi o halogeno en las posiciones 3, 5, y 6, y sus derivados de acido y amina de la formula (I) en donde X representa H, halogeno alcoxi C1-C6, alquiltio C1-C6, ariloxi, heteroariloxi o trifluorometilo; Y representa halogeno, alcoxi C1-C6, alquiltio C1-C6, ariloxi, heteroariloxi o trifluorometilo; Z representa halogeno, alcoxi C1-C6, alquiltio C1-C6, ariloxi o nitro; y W representa -NO2, -N3, -NR1 R2, -N=CR3R4, son herbicidas potentes que demuestran un amplio espectro de control de maleza.

4-aminopicolinates and their use as herbicides

4-Aminopicolinates and their use as herbicides

4-Aminopicolinates and their use as herbicides.

4-aminopicolinates and their use as herbicides

4-Aminopicolinates and herbicidal compositions comprising the same

본 발명은 넓은 잡초 방제 스펙트럼을 나타내는 강력한 제초제인, 3, 5 및 6위치에 할로겐, 알콕시, 알킬티오, 아릴옥시, 헤테로아릴옥시 또는 트리플루오로메틸 치환체를 갖는 화학식 1의 4-아미노피콜린산과, 이의 아민 및 산 유도체에 관한 것이다. The present invention relates to 4-aminopicolinic acid of formula (I) having halogen, alkoxy, alkylthio, aryloxy, heteroaryloxy or trifluoromethyl substituents at positions 3, 5 and 6, which are potent herbicides with broad weed control spectrum. , Amines and acid derivatives thereof. 화학식 1 Formula 1 위의 화학식 1에서, In Formula 1 above, X는 H, 할로겐, C 1 -C 6 알콕시, C 1 -C 6 알킬티오, 아릴옥시, 니트로 또는 트리플루오로메틸이고, X is H, halogen, C 1 -C 6 alkoxy, C 1 -C 6 alkylthio, aryloxy, nitro or trifluoromethyl, Y는 할로겐, C 1 -C 6 알콕시, C 1 -C 6 알킬티오, 아릴옥시, 헤테로아릴옥시 또는 트리플루오로메틸이고, Y is halogen, C 1 -C 6 alkoxy, C 1 -C 6 alkylthio, aryloxy, heteroaryloxy or trifluoromethyl, Z는 할로겐, C 1 -C 6 알콕시, C 1 -C 6 알킬티오, 아릴옥시 또는 니트로이고, Z is halogen, C 1 -C 6 alkoxy, C 1 -C 6 alkylthio, aryloxy or nitro, W는 -NO 2 , -N 3 , -NR 1 R 2 , -N=CR 3 R 4 또는 -NHN=CR 3 R 4 이다. W is -NO 2 , -N 3 , -NR 1 R 2 , -N = CR 3 R 4 or -NHN = CR 3 R 4 . 제초제, 잡초, 아미노피콜리네이트, 아민, 방제 Herbicides, weeds, aminopicolinate, amines, control

4-aminopicolinates and their use as herbicides

4-AMYNOPYCHOLINATES AND ITS USE AS HERBICIDES.

Un compuesto de Fórmula I: en la que Y representa halógeno, alcoxi C1-C6, alquil(C1-C6)tio, ariloxi, heteroariloxi o trifluorometilo; Z representa halógeno, alcoxi C1-C6, alquil(C1-C6)tio, ariloxi o nitro; y W representa -NO2, -N3, -NR1R2, -N=CR3R4 o -NHN=CR3R4 donde R1 y R2 representan independientemente H, alquilo C1-C6, alquenilo C3-C6, alquinilo C3-C6, arilo, heteroarilo, hidroxi, alcoxi C1-C6, amino, acilo C1-C6, carboalcoxi C1-C6, alquil(C1-C6)carbamilo, alquil(C1-C6)sulfonilo, trialquil(C1-C6)sililo o dialquil(C1-C6)fosfonilo o R1 y R2 tomados junto con N representan un anillo saturado o insaturado de 5 ó 6 miembros que puede contener heteroátomos de O, S o N adicionales; y R3 y R4 representan independientemente H, alquilo C1-C6, alquenilo C3-C6, alquinilo C3-C6, arilo o heteroarilo o R3 y R4 tomados junto con =C representan un anillo saturado de 5 ó 6 miembros; en la que alquilo, alquenilo, alquinilo, alcoxi, acilo, alquiltio y alquilsulfonilo pueden estar cada uno sin sustituir o sustituido con uno o más sustituyentes seleccionados entre halógeno, hidroxi, alcoxi, alquiltio, acilo C1-C6, formilo, ciano, ariloxi o arilo; y en la que arilo o heteroarilo pueden estar sin sustituir o sustituidos con uno o más sustituyentes seleccionados entre halógeno, hidroxi, nitro, ciano, ariloxi, formilo, alquilo C1-C6, alquenilo C2-C6, alquinilo C2-C6, alcoxi C1-C6, alquilo C1-C6 halogenado, alcoxi C1-C6 halogenado, acilo C1-C6, alquil(C1-C6)tio, alquil(C1-C6)sulfinilo, alquil(C1-C8)sulfonilo, arilo, alquil(C1-C6)OC(O), alquil(C1-C6)NHC(O), C(O)OH, alquil(C1-C6)C(O)O, C(O)NH2, alquil(C1-C6)C(O)NH y (alquilo)2(C1- C6)C(O)N; y derivados agrícolamente aceptables del ácido carboxílico, seleccionados entre cualquier derivado sal, éster, acilhidrazida, imidato, tioimidato, amidina, amida, ortoéster, acil cianida, haluro de acilo, tioéster, tionoéster, éster de ditiol y nitrilo de la funcionalidad de ácido carboxílico de la posición 2, así como N-óxidos que pueden romperse dando ...