25-07-2013 дата публикации
Номер: US20130190327A1
The invention relates to bis-fatty acid conjugates; compositions comprising an effective amount of a bis-fatty acid conjugate; and methods for treating or preventing cancer, a metabolic disease or a neurodegenerative disease comprising the administration of an effective amount of a bis-fatty acid conjugate. 1. A molecular conjugate , directly or indirectly covalently linked wherein the linker comprises at least one amide , comprising two or more fatty acids selected from the group consisting of omega-3 fatty acids , fatty acids that are metabolized in vivo to omega-3 fatty acids , and lipoic acid , with the proviso that the molecular conjugate is not (4Z ,7Z ,10Z ,13Z ,16Z ,19Z)-docosa-4 ,7 ,10 ,13 ,16 ,19-hexaenoic acid {2-[2-((4Z ,7Z ,10Z ,13Z ,16Z ,19Z)-docosa-4 ,7 ,10 ,13 ,16 ,19-hexaenoylamino)-ethylamino]-ethyl}-amide (A); (5Z ,8Z ,11Z ,14Z ,17Z)-icosa-5 ,8 ,11 ,14 ,17-pentaenoic acid {2-[2-((5Z ,8Z ,11Z ,14Z ,17Z)-icosa-5 ,8 ,11 ,14 ,17-pentaenoylamino)-ethylamino]-ethyl}-amide (B); (4Z ,7Z ,10Z ,13Z ,16Z ,19Z)-docosa-4 ,7 ,10 ,13 ,16 ,19-hexaenoic acid {2-[2-((4Z ,7Z ,10Z ,13Z ,16Z ,19Z)-docosa-4 ,7 ,10 ,13 ,16 ,19-hexaenoylamino)-ethoxy]-ethyl}-amide (C); (5Z ,8Z ,11Z ,14Z ,17Z)-icosa-5 ,8 ,11 ,14 ,17-pentaenoic acid {2-[2-((5Z ,8Z ,11Z ,14Z ,17Z)-icosa-5 ,8 ,11 ,14 ,17-pentaenoylamino)-ethoxy]-ethyl}-amide (D); or (S)-2 ,6-Bis-((4Z ,7Z ,10Z ,13Z ,16Z ,19Z)-docosa-4 ,7 ,10 ,13 ,16 ,19-hexaenoylamino)-hexanoic acid (E).2. The molecular conjugate of claim 1 , wherein the fatty acid is selected from the group consisting of all-cis-7 claim 1 ,10 claim 1 ,13-hexadecatrienoic acid claim 1 , α-linolenic acid claim 1 , stearidonic acid claim 1 , eicosatrienoic acid claim 1 , eicosatetraenoic acid claim 1 , eicosapentaenoic acid (EPA) claim 1 , docosapentaenoic acid claim 1 , docosahexaenoic acid (DHA) claim 1 , tetracosapentaenoic acid claim 1 , tetracosahexaenoic acid and lipoic acid.3. The molecular conjugate of claim 2 , wherein the fatty acid is selected from ...
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