СОЕДИНЕНИЯ, ПРИМЕНЯЕМЫЕ В ЛЕЧЕНИИ НЕОПЛАСТИЧЕСКИХ ЗАБОЛЕВАНИЙ

Настоящее изобретение относится к соединениям и их фармацевтически приемлемым солям, которые применяются в лечении неопластических заболеваний или расстройств, фармацевтической композиции, содержащей такое соединение, и способу получения этого соединения. Лекарственное средство для лечения неопластического заболевания или (дис)пролиферативного расстройства, содержащее соединение, выбранное из группы, состоящей из:,,,,. Лекарственное средство для лечения злокачественной опухоли, содержащее соединение. 7 н. и 7 з.п. ф-лы, 9 ил., 2 табл., 8 пр.

КОМПОЗИЦИЯ ПРОКАТАЛИЗАТОРА, ВКЛЮЧАЮЩАЯ СИЛИЛОВЫЙ СЛОЖНЫЙ ЭФИР КАК ВНУТРЕННИЙ ДОНОР, А ТАКЖЕ СПОСОБ

Изобретение относится к области катализа. Описана композиция прокатализатора, включающая комбинацию из магниевого фрагмента. титанового фрагмента и внутреннего донора электронов, при этом внутренний донор электронов включает силиловый сложный эфир, имеющий структуру:где R-Rпредставляют собой водород, Rи Rявляются идентичными или различными и каждый выбирают из группы, состоящей из атома водорода и Салкильной группы. Описана композиция катализатора, включающая указанную выше композицию прокатализатора и сокатализатор и ее использование в получении полимера на олефиновой основе. Технический результат - увеличение активности композиции катализатора. 3. н. и 4 з.п. ф-лы, 9 табл., 3 пp.

НОВЫЕ ДИОРГАНОСИЛОКСАНЫ ИЛИ ТРИОРГАНОСИЛАНЫ, СВЕТОЗАЩИТНАЯ КОСМЕТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ЗАЩИТЫ КОЖИ И/ИЛИ ВОЛОС ОТ УЛЬТРАФИОЛЕТОВОГО ИЗЛУЧЕНИЯ

Ди- или триорганосилоксаны с короткими, линейными или циклическими цепями содержат по крайней мере одно фильтрующее звено, происходящее от оксанилида с алкиленовой или алкиленоксифункцией, причем эти соединения преимущественно используют в качестве органических солнечных фильтров в косметических композициях, предназначенных для защиты кожи и волос от ультрафиолетового излучения. Органосилоксаны обладают хорошей растворимостью в жировых веществах и превосходной фотостабильностью. 3 с. и 20 з.п.ф-лы.

СПОСОБ ПОЛУЧЕНИЯ КРЕМНИЙОРГАНИЧЕСКОГО СОЕДИНЕНИЯ

Изобретение относится к металлоорганической химии. Предложен способ получения нового кремнийсодержащего соединения - дифенил-бис(4-бромфенилметил)силана. Способ заключается во взаимодействии 4-бромбензилмагнийбромида с дифенилдихлорсиланом в эфирной среде. Способ характеризуется тем, что дифенил-бис(4-бромфенилметил)силан получают взаимодействием молекулярного брома с п-бромтолуолом, выделением п,α-дибромтолуола, получением 4-бромбензилмагнийбромида в эфирной среде и воздействием на него при охлаждении дифенилдихлорсиланом в соотношении 2:1 соответственно, последующим отгоном растворителя на роторном испарителе. Технический результат: предложенный способ позволяет получить дифенил-бис(4-бромфенилметил)силан с выходом целевого соединения - 45-50% от теоретического, обладающего устойчивостью при длительном хранении в условиях комнатной температуры.

КРЕМНИЙСОДЕРЖАЩИЕ СОЕДИНЕНИЯ ИЛИ ИХ СОЛИ, ОБЛАДАЮЩИЕ ФУНГИЦИДНОЙ АКТИВНОСТЬЮ, И СПОСОБ ИХ ПОЛУЧЕНИЯ

Соединения формулы I в которой А представляет собой 1,2,4-триазол-1-ил или имидазол-1-ил, n равно 0, 1, 2 или 3, Х представляет собой галоген, фенил, алкил, галоидалкил, алкокси или галоидалкокси, или (Х)n представляет собой алкилендиокси, R1 представляет собой алкил или фенил, R1 и R2 каждый представляет собой алкил, и соли этих соединений проявляют полезную противогрибковую активность. Описываются также некоторые промежуточные продукты, получаемые при приготовлении данных соединений. 7 табл., 4 ил.

СОЕДИНЕНИЯ СИЛИНАНА В КАЧЕСТВЕ ИНГИБИТОРОВ ЦИСТЕИНОВОЙ ПРОТЕАЗЫ

... 1. Соединение формулы (I) в которой Q представляет собой -СО-, -SO2-, -ОСО-, -NR4CO-, -NR4SO2- или -CHR-, где R представляет собой галоалкил, а R4 представляет собой водород, алкил, гидроксиалкил, алкоксиалкил или аралкил; Е представляет собой (i) -C(R5)(R6)X1, где X1 представляет собой -C(R7)(R8)R10, -CH=CHS(O)2R10, -C(R7)(R8)C(R7)(R8)OR10, -C(R7)(R8)CH2OR10, -C(R7)(R8)CH2N(R11)SO2R10, -C(R7 )(R8)C(O)N(R11)(CH2)2OR11, -C(R7)(R8)C(O)NR10R11 или -C(R7)(R8)C(O)N(R11)(CH2)2NR10R11; (ii) -C(R5a)(R6a)CN; где R5 и R5a независимо представляют собой водород или алкил; R6 и R6a независимо являются выбранными из группы, состоящей из водорода, алкила, галоалкила, циклоалкила, циклоалкилалкила, арила, аралкила, гетероарила, гетероаралкила, гетероциклоалкила, гетероциклоалкилалкила, -алкилена-Х2-R12 (где Х2 представляет собой -O-, -NR13-, -S(O)n1 -, -CONR13-, -NR13CO-, -NR13C(O)O-, -NR13CONR13-, -OCONR13-, -NR13SO2-, -SO2NR13-, -NR13SO2NR13-, -CO- или -ОС(O)-, где n1 равен 0-2, а каждый R13 представляет ...

Новый способ получения эверолимуса

Группа изобретений относится к способам получения промежуточных соединений, используемых для синтеза эверолимуса, и способам получения эверолимуса. Предложен способ получения предшественника эверолимуса из рапамицина и кремнийорганического соединения в присутствии насыщенного азотсодержащего гетероцикла, его вариант и соответствующие варианты последующего получения эверолимуса. Технический результат – предложенные способы получения промежуточных соединений и последующего получения из них эверолимуса позволяют повысить выход и чистоту конечного продукта, а также уменьшить количество отходов производства. 4 н. и 99 з.п. ф-лы, 2 табл., 7 пр.

СПОСОБ ПОЛУЧЕНИЯ ФЕНИЛСОДЕРЖАЩИХ ХЛОРСИЛАНОВ С АЛИФАТИЧЕСКИМИ ИЛИ ЦИКЛОПАРАФИНОВЫМИ УГЛЕВОДОРОДНЫМИ РАСТВОРИТЕЛЯМИ

... 1. Способ получения фенилметилдихлорсиланов и дифенилметилхлорсиланов по реакции Гриньяра, включающий взаимодействие фенильного реактива Гриньяра, простого эфирного растворителя, трихлорсилана и алифатического или циклопарафинового углеводородного растворителя реакции сочетания; при этом молярное отношение простого эфирного растворителя к фенильному реактиву Гриньяра составляет 2 к 5, молярное отношение трихлорсилана к фенильному реактиву Гриньяра составляет 0,1 к 10, и молярное отношение алифатического или циклопарафинового углеводородного растворителя реакции сочетания к фенильному реактиву Гриньяра составляет 3 к 7. 2. Способ по п.1, в котором фенильным реактивом Гриньяра является хлорид фенилмагния. 3. Способ по п.1 или 2, в котором простым эфирным растворителем является простой диалкиловый эфир, выбранный из группы, включающей простой диметиловый эфир, простой диэтиловый эфир, простой этилметиловый эфир, простой н-бутилметиловый эфир, простой н-бутилэтиловый эфир, простой ди-н-бутиловый ...

ПРОЦЕСС ГРИНЬЯРА С УВЕЛИЧЕННЫМИ ВЫХОДАМИ ДИФЕНИЛХЛОРСИЛАНОВ В КАЧЕСТВЕ ПРОДУКТОВ

... 1. Способ получения дифенилхлорсиланов процессом Гриньяра, включающий контактирование фенильного реагента Гриньяра, растворителя из класса простых эфиров, трихлорсилана и растворителя для реакции сочетания из класса ароматических углеводородов, в котором мольное отношение эфирного растворителя к фенильному реагенту Гриньяра составляет от 2 до 5, мольное отношение трихлорсилана к фенильному реагенту Гриньяра составляет от 0,1 до 10, и мольное отношение ароматического углеводородного растворителя реакции сочетания к фенильному реагенту Гриньяра составляет от 3 до 7. 2. Способ по п. 1, в котором фенильным реагентом Гриньяра является фенилмагнийхлорид. 3. Способ по п.1 или 2, в котором эфирным растворителем является диалкильный эфир, выбранный из группы, состоящей из диметилового эфира, диэтилового эфира, этилметилового эфира, н-бутилметилового эфира, н-бутилэтилового эфира, ди-н-бутилового эфира, диизобутилового эфира, изобутилметилового эфира и изобутилэтилового эфира. 4. Способ по п.1 или ...

СИЛАНОВЫЕ КОМПОЗИЦИИ, СПОСОБЫ ИХ ПОЛУЧЕНИЯ И РЕЗИНОВЫЕ КОМПОЗИЦИИ, ИХ СОДЕРЖАЩИЕ

... 1. Силановая композиция, содержащая где R и R1 независимо представляют собой углеводородные группы с от 1 до примерно 20 атомами углерода; R2 независимо представляет собой водород или углеводородную группу с от 1 до примерно 20 атомами углерода; М представляет собой двухвалентную углеводородную связывающую группу с от 1 до примерно 20 атомами углерода для связывания атома кремния и L группы; L представляет собой ковалентно связанную углеводородную линкерную группу с от 1 до примерно 20 атомами углерода или гетероатомную линкерную группу, выбранную из группы, состоящей из -О-, -S- -NR3-, где R3 представляет собой связь или углеводородную группу с от 1 до примерно 20 атомами углерода; Ra представляет собой алкиленовую группу с от 1 до 12 атомами углерода; Ar представляет собой незамещенную или замещенную ароматическую группу; q представляет собой целое число от 1 до 4; t и с каждый независимо представляет собой 0 или 1 и х, y, z каждый независимо представляет собой целые числа от 1 до 3 включительно ...

Производные арилпропилморфолина, обладающие фунгицидной активностью

Использование: в качестве вещества, обладающего фунгицидной активностью. Сущность изобретения: продукт-производные эрилпропил- морфолина ф-лы 1, R-C -С или 1, Y-C -С дихлорлиридил , нитропиридиа пиримидинил - 2, Si(CHJ D, D-Ct-C Реагент 1:4 - 3 - (4 - гидро- ксифенил) - 2 - метилпропил -2.6- диметилмор- фопии Реагент 2: G-(CH ) -у. где G-галоген Условия реакции: нагревание. 3 табл. Структурная формула1 сн 3Ьл О N-CH - CH(R)- CH Ь 2 сн (X ...

Silacyclohexanverbindung, Verfahren zu deren Herstellung und diese enthaltende Flüssigkristallzusammensetzung

VERFAHREN ZUR HERSTELLUNG VON (ARYL)-(DIMETHYL)-(3-(4-FLUORO-3-ARYLOXYPHENYL)PROPYL)SILANEN

Kieselgelhaltige Kautschukcompounds mit Organosilciumverbindungen als Compoundiermittel

MONOCARBONSÄURESALZE VON IMIDAZOLREAKTIONSPRODUKTEN, VERFAHREN ZUR HERSTELLUNG DER SALZE, UND OBERFLÄCHENBEHANDLUNGEN, ZUSÄTZE FÜR HARZE UND HARZZUSAMMENSETZUNGEN WELCHE DIESE ENTHALTEN

MONOMERE ZUR REDUZIERUNG DES MODULUS VON SILOXYNHYDROGELE

SYNTHESE VON N-SILYLIERTEN VERBINDUNGEN

PROCESS FOR THE MANUFACTURE OF AMINO-DERIVATIVES OF N-HETEROCYCLIC COMPOUNDS

... 1418298 Amino derivatives of aromatic N -heterocyclic compounds SCHERING AG 11 Dec 1972 [18 Dec 1971] 57077/72 Heading C2C A process for the manufacture of amino derivatives of N-heterocyclic compounds comprises silylating an aromatic N-heterocyclic compound that is substituted by at least one hydroxyl or mercapto group and reacting the resulting O and/or S silylated compound with either (i) ammonia or an amine of the formula HN(R 1 )(R 2 ) wherein R 1 and R 2 each represent a hydrogen atom or an alkyl, aralkyl, aryl or hetrocyclic group, or R 1 is a hydrogen atom and R 2 is a hydroxyl or amino group or a terminally substituted alkyl group, or R 1 and R 2 together with the nitrogen atom represent a heterocyclic group, in the presence of a Lewis acid catalyst, or (ii) a salt of such an amine as above in the presence of both a Lewis acid catalyst and a tertiary base, the catalyst in process (i) or (ii) being present in an amount of from 0À001 to 5 moles per mole of the silylated compound.

Compositions and methods for the production of coloured glass fibres

Copolymer silazanes prepared by the reaction of ammonia and a mixture of 20-80 mol per cent R2SiHal21 the balance of the mixture being RSiHal3, wherein Hal is a halogen atom and R is H or an alkyl or alkenyl radical of 1-7 C or an aryl radical, are employed in the dyeing of glass fibres. The Example (1) methyltrichlorosilane and dimethyldichlorosilane (4:1) in methylene chloride are reacted with NH3 in an atmosphere of nitrogen. In other examples further mixtures of silanes are specified. U.S.A. Specifications 2,462,635, 2,579,417 and 2,579,418 are referred to.ALSO:A process for colouring glass fibres and fabrics comprises applying thereto a dye and the reaction product of ammonia and a mixture of 20-80 mol per cent of a halosilane R2SiHal2, the balance of the mixture being a halosilane RSiHal3 in which formulae Hal is a halogen atom and R is a hydrogen atom or an alkyl or alkenyl group of 1-7 C atoms or an axyl group. The preferred types of dye are acetate, basic, vat and pigment dyes.

Process of making cyanoalkylsilanes

Aminoalkylalkoxysilanes (see Group IV(a)) may be applied to metal articles and cured on the surface to provide protective coatings. The silanes have the formula X3SiCaH2aNH2, where X is alkoxy and a is 3 or more. Specification 847,805 is referred to.ALSO:Cyanoalkylsilanes in which the cyano group is connected to the silicon atom through at least 2 carbon atoms are prepared by reacting an alkene nitrile with a silane HSiX3, where X is a hydrolysable group other than hydrogen, in the presence of a tertiary silyl amine catalyst of the formula A4-ySi(NR2)y where A is a monovalent hydrocarbon group, an alkoxy group or halogen, R is an alkyl group and y is 1 to 4. Typical examples of catalysts are (CH3)3SiN (C4H9)2, ClSi[N(C2H5)2]3 and (Eto)3 SiN(CH3)2. Reaction temperatures are generally from 50 DEG to 250 DEG C. To reduce the amount of heavies formed, a silane of the formula RSiHX2 (X being a hydrolysable group and R a monovalent hydrocarbon group) may be added to the reaction mixture. A polymerisation ...

Tin organosilicon compounds

The lubricating properties of organosiloxane fluids are improved by the addition of tin alkyl silalkyl silanes of the general formula where x is a monovalent hydrocarbon radical free from aliphatic unsaturation, an alkoxy group or a chlorine or bromine atom, R is a monovalent hydrocarbon radical free from aliphatic unsaturation, R1 is an alkyl or phenyl radical, Z is hydrogen or methyl, x is 1, 2 or 3, q is 0, 1 or 2, x+q is 1, 2 or 3, y is at least 2, m is 0 or 1 and n is 0 or is 1 when m is 1, or polysiloxanes derived therefrom (see Group IV(a)). Specifications 804,097 and 891,087 are referred to.ALSO:The invention comprises tin alkylsilalkyl silanes and polysiloxanes derived therefrom, the silanes having the general formula where X is a monovalent hydrocarbon radical free from aliphatic unsaturation, an alkoxy radical or a chlorine or bromine atom, R is a monovalent hydrocarbon radical free from aliphatic unsaturation, R1 is an alkyl or phenyl ...

Improvements in or relating to the production of organo-silicon compounds by the grignard reaction

Compounds of the formula RxSi(OR1)4-x where R and R1 are the same or different alkyl, aryl or aralkyl groups, and hydrolysis products thereof, are prepared by reacting the corresponding Grignard reagent with a tetra-organo silicate in the presence of a solvent therefor, the amount of solvent present at the end of the reaction being so adjusted that the silicon compound and the resulting magnesium compound formed in the reaction are dispersed in a liquid phase. The liquid reaction product is hydrolyzed and resolved into two immiscible phases by means of a dilute aqueous mineral acid and the organo-silicon compound is recovered from the organic phase. In a particular form of the invention the organic halide used for forming the Grignard reagent may be used in such excess as to act as the solvent medium for the reaction. In example (1) magnesium turnings are stirred into a large excess of dry ether with a portion of p-tolyl bromide, and tetra-ethoxy silicane is added followed by the remainder ...

PROCEDURE FOR THE PRODUCTION OF NEW N-TRIALKYL (AND/OR N-DIALKYLCHLOR) - SILYL-2-OXAZOLIDINONEN

SILIZIUMVERBINDUNGEN AND THEIR USE

ORGANOSILIZIUMVERBINDUNGEN AND THEIR USE

STABILIZATION OF NITROGENOUS AND OXYGEN-CONTAINING ORGANOSILANE WITH WEAKLY BASIC ION EXCHANGE RESINS

SILYLIERTE CARBOXAMIDE

SILIZIUMHALTIGEN SUBSTITUTED PHOTO STABILIZATION OF A DIBENZOYLMETHANS ON THE BASIS A WITH TWO AMINOBENZOATODER AMINOBENZAMIDGRUPPEN S-TRIAZINS AS WELL AS LIGHT PROTECTION COMPOSITIONS NEW ONE SILIZIUMHALTIGE S-TRIAZINVERBINDUNGEN

MIKROBIZIDE SILYLIERTE CARBOXAMIDE

PROCEDURE FOR THE PRODUCTION OF N-2AMINOETHYLAMINOALKYLALKOXYSILANEN WITH ETHYL DIAMINE SALT RECUPERATION

TI, TA, HF, ZR AND ZUGEHÍRIGE METAL SILICON AMIDES TO THE ALD/CVD OF METAL SILICON NITRIDES, OXIDES OR OXYNITRIDEN

ORGANOSILIKON DERIVATIVES OF AMINOHYDROXYBENZOPHENONEN AND YOUR USE AS UV-A-FILTERS IN COSMETIC PREPARATIONS

COMPOSITION FOR HYDROPHOBE TREATMENT AND GLAZING

PROCEDURE FOR THE PREVENTION OF THE POLYMERIZATION OF INSATIATED ORGANOSILICIUMVERBINDUNGEN

ON SILICON BASED COMPOSITIONS WITH QUATERNÄREN AMMONIUM FUNCTIONS AND PROCEDURE FOR YOUR PRODUCTION

SILICONE CONNECTIONS WITH MIKROBIZIDER EFFECT

REGIOSELEKTIVE SYNTHESIS OF 4-CHLOR-2 THIOPHENCARBONSÄURE

PROCEDURE FOR THE PRODUCTION OF POLYHEDRI OLIGOMERER SILSESQUIOXANE

LIGAND WITH AT LEAST A FLUOROSILIZIUM SUBSTITUENT FOR THE PRODUCTION OF METALLOCENEN

POLYFUNCTIONAL ORGANOSILANE FOR THE EMPLOYMENT AS CLUTCH MEANS AS WELL AS PROCEDURES FOR THEIR PRODUCTION

PROCEDURE FOR THE PRODUCTION OF ORGANOFUNKTIONELLER SILANES

PROCEDURE FOR THE PRODUCTION OF ORGANOSILYLALKYLPOLYSULFANEN

ALKYL-4-SILYL-PHENOLE AND THEIR ESTER AS ANTIATHEROSCLEROTI MEANS

BORON AND/OR ALUMINUM-BEARING MIXTURES, HYBRID MATERIALS AND COATINGS

ORGANOSILOXANE/METAL OXIDE COATINGS

Process for the preparation of thiocarboxylate silane

Fungicide N-[(trisubstitutedsilyl)methyl]-carboxamide derivatives

The present invention relates to fungicidal N-[(trisubstitutedsilyl)methyl]carboxamide or its thiocarboxamide derivative, their process of preparation and intermediate compounds for their preparation, their use as fungicides, particularly in the form of fungicidal compositions and methods for the control of phytopathogenic fungi of plants using these compounds or their compositions.

Synthesis of silyl camptothecins and silyl homocamptothecins

SUBSTITUTED SILYL ALCOHOLS

Novel sunscreens, photoprotective cosmetic compositions containing them and uses thereof

ALKOXYSILANES AND METHOD FOR MAKING

Alkoxysilylscrylamides, alkoxysilyracrylates and alkoxysilylbenzylidene malonates are provided and a method for making such materials. These alkoxysilanes have been found useful as UV stabilizers and as adhesion promoters when incorporated into silicone compositions useful as top coats for thermoplastic organic polymers.

CARBENIUM CATIONIC COMPLEXES SUITABLE FOR POLYMERIZATION CATALYSTS

This description addresses a process for the preparation of polyolefins from one or more olefinic monomers comprising combining under polymerization conditions said olefins with the product of combining i) an organometallic catalyst compound and ii) a cocatalyst complex comprising a trialkylsilyl- substituted carbenium cation and a suitable noncoordinating or weakly coordinating anion. These complexes exhibit good solubility in aliphatic solvents such that use in aliphatic solution based polymerization reaction processes can be conducted without the use of aromatic solvents or co-solvents and without the need for slurry means of introduction into chemical reaction environments. High number-average molecular weight polymers and copolymers at high rates of productivity were observed from the use of metallocene catalysts complexes when activated with [(3, 5-(Et3Si)2Ph)3C]+ [(C6F5) B]- and used in a hexane-based solution polymerization.

WATER REPELLENT COMPOSITIONS

NOVEL INDENE-BASED TRANSITION METAL COMPOUND, TRANSITION METAL CATALYST COMPOSITION COMPRISING SAME, AND METHOD FOR PREPARING ETHYLENE HOMOPOLYMER OR COPOLYMER OF ETHYLENE AND .ALPHA.-OLEFIN BY USING SAME

The present invention relates to: a novel indene-based transition metal compound; a transition metal catalyst composition comprising same and having a high catalytic activity for preparing an ethylene homopolymer or a copolymer of ethylene and one or more a-olefins; a method for preparing an ethylene homopolymer or a copolymer of ethylene and an a-olefin by using the transition metal catalyst composition; and an ethylene homopolymer or a copolymer of ethylene and an a-olefin prepared thereby.

COATING METHODS USING ORGANOSILICA MATERIALS AND USES THEREOF

Methods for coating a substrate with a coating including an adsorbent material and a binder comprising an organosilica material which is a polymer comprising independent units of Formula [Z3Z4SiCH2] 3 (I), wherein each Z3 represents a hydroxyl group, a C1-C4 alkoxy group or an oxygen atom bonded to a silicon atom of another unit or an active site on the substrate and each Z4 represents a hydroxyl group, a C1-C4 alkoxy group, a C1-C4 alkyl group, an oxygen atom bonded to a silicon atom of another unit or an active site on the substrate are provided. Methods of gas separation are also provided.

3-ARYL PROPIOLONITRILE COMPOUNDS FOR THIOL LABELING

The present invention relates to a process for labeling compounds comprising thiol moieties with 3-arylpropiolonitrile compounds, to 3-arylpropiolonitrile compounds substituted with tag moieties and to specific 3-arylpropiolonitrile linkers.

METHOD FOR PREPARING 1-METHYL CYCLOPROPENE AND ADDING SAME TO PLANTS

The present invention provides a method whereby 1-MCP, which inhibits the action of ethylene promoting fast plant growth, is directly prepared in situ by the reaction of 1-methyl cyclopropene (1-MCP), which is the compound of chemical formula 2 or 3, with a base or an anionic fluorine substance, and is added to a plant.

SYNTHESIS OF INTERMEDIATE FOR TREPROSTINIL PRODUCTION

The compound according to Formula I is an intermediate in the synthesis of prostacylin analogs. The present invention provides an efficient method for synthesizing a Formula I compound.

APPARATUS FOR GENERATING 1-METHYLCYCLOPROPENE

Provided is an apparatus for generating 1-methylcyclopropene. The apparatus of the present invention may enable the immediate and convenient generation of 1-methylcyclopropene in a desired location using stable 1-methylcyclopropene precursors.

MERCAPTOSILANE-CARBON BLACK BLEND

The invention relates to mercaptosilane-soot blends, containing at least 20% by weight of mercaptosilane with the general formula I Si R R 2 R 2 R 3 S R 4 I and soot, wherein the mercaptosilane-soot blend has an iron content of < 9 ppm. The blends are produced by mixing the mercaptosilane with the general formula I with the soot. The blends can be used in rubber mixtures.

A COMPOUND 1,4,5-TRISUBSTITUTED1,2,3-TRIAZOLE, PROCESS TO OBTAIN IT AND USES THEREOF

The present invention relates to nonpeptide compounds of formula (I), containing a central 1,4,5- trisubstituted 1,2,3-triazole core and a reactive appendage appropriate to form covalent "click" bonds on the surface of materials functionalized with reactive groups including: azide, terminal alkyne, cyclooctalkyne, thiol, maleimide or thiolacid groups. These compounds are nonpeptide mimetics of RGD (Arg-Gly- Asp) and/or OGP10-14 (Tyr-Gly-Phe-Gly-Gly), osteogenic peptides. Also, the present invention relates to a process for the preparation of the compounds containing a 1,4,5-trisubstituted 1,2,3-triazole core. These compounds are particularly useful for medical devices, in particular implants and tissue engineering and cell culture matrices.

FUNGICIDAL SILICON-CONTAINING COMPOUNDS, THEIR PREPARATION AND THEIR AGROCHEMICAL AND MEDICINAL USES

Compounds of formula (I): (I) wherein: A is 1,2,4-triazol-1-yl or imidazol-1-yl; n is 0, 1, 2 or 3; X is halogen, phenyl, alkyl, haloalkyl, alkoxy, or haloalkoxy, or (X)n is alkylenedioxy; R1 is alkyl or phenyl; and R2 and R3 are each alkyl; and salts thereof have valuable anti-fungal activity. Certain intermediates in the preparation of these compounds are also disclosed.

2,6-DI-ALKYL-4-SILYL-PHENOLS AS ANTIATHEROSCLEROTIC AGENTS

This invention relates to certain 2,6-dialkyl-4-silyl-phenols of the formula: wherein R1, R2, R3 and R4 are each independently a C1-C6 alkyl group; Z is a thio, oxy or methylene group; A is a C1-C4 alkylene group; and R5 is a C1-C6 alkyl or -(CH2)n-(Ar) wherein n is an integer 0, 1, 2 or 3, and Ar is phenyl or napthyl unsubstituted or substituted with one to three substituents selected from the group consisting of hydroxy, methoxy, ethoxy, chloro, fluoro or C1-C6 alkyl; which are useful as inhibitors of LDL lipid peroxidation and as antiatherosclerotic agents.

SURFACE-MODIFIED MICACEOUS PARTICULATES HAVING IMPROVED DISPERSIBILITY IN AQUEOUS MEDIA

Compounds useful for improving the dispersibility of micaceous particulates in aqueous-based coating compositions comprise urethanes or ureas which are the reaction products of silylalkyl or silylaryl isocyanates with alcohols, amines, polyether alcohols or amineterminated polyethers. The compounds may also be the reaction products of silylalkyl- or silylarylamines with half-blocked diisocyanates which are themselves the reaction products of a diisocyanate with an alcohol, amine, polyether alcohol or amine-terminated polyether. Micaceous particulates which have been surface modified by reaction with these compounds, as well as coating compositions comprising such surface-modified micaceous particulates, and coated substrates are also disclosed. 54 ...

ANTIMICROBIAL SILOXANE QUATERNARY AMMONIUM SALTS

A siloxane quaternary ammonium salt is provided which can be either of two general classes: (1) a trisiloxane having a pendent quaternary ammonium group and a molecular weight of from about 600 to about 1,700; and (2) an ABA-type siloxane having a polydispersity of up to about 3.0 and a weight-average molecular weight of from about 800 to about 2,000, in which a central siloxane moiety is terminated at each end by a quaternary ammonium salt group. The anion in general can be any anion which does not adversely affect the thermal stability of the salt. The siloxane quaternary ammonium salt possesses antimicrobial properties and is intended for inclusion in a thermoplastic composition which can be melt extruded to form fibers and nonwoven webs, or other shaped articles, which exhibit antimicrobial properties.

LIQUID-CRYSTALLINE ORGANOSILOXANES CONTAINING CHIRAL DIANHYDROHEXITOL DERIVATIVES

The liquid-crystalline organosiloxanes which contain dianhydrohexitol derivatives as chiral groups can be used in optical elements, for decorative purposes and as polarizing colored filters, in particular notch filters.

Verfahren zur Herstellung neuer Telomerisate

VERFAHREN ZUR HERSTELLUNG VON SILIZIUMORGANISCHEN VERBINDUNGEN UND DEREN VERWENDUNG.

Verfahren zur Herstellung von Organodikaliumsilanen

VERFAHREN ZUR HERSTELLUNG VON COPOLYMERISATEN, SO HERGESTELLTE COPOLYMERISATE UND DEREN VERWENDUNG.

SILICONAT SILYLORGANOPHOSPHONAT AND ITS USE AGAINST METAL CORROSION.

PROCEDURE FOR THE PRODUCTION FUNCTIONAL OF SUBSTITUTED SILANES.

TRIAZOLE RECEPTOR AGONISTS APJ

Hydrosilylation reaction catalyst

A through rearrangement reaction of benzyl chloride silane method of preparation

ＯＬＥＤ용 호스트 물질

... 본 발명은 신규한 아릴 규소 및 아릴 게르마늄 호스트 물질에 관한 것이다. 이들 화합물은 OLED의 발광층에서 호스트로서 사용시 OLED 디바이스 성능을 개선시킨다.

METALLOCENE COMPOUNDS, CATALYST COMPOSITIONS COMPRISING THE SAME, AND METHOD FOR PREPARING OLEFIN POLYMERS USING THE SAME

MATERIAL FOR ORGANIC ELECTROLUMINESCENT ELEMENTS AND ORGANIC ELECTROLUMINESCENT ELEMENT USING SAME

폴리에테르-폴리실록산 거대단량체 단위를 함유하는 공중합체, 이의 제조 방법 및 코팅 조성물 및 중합체성 성형 화합물에서의 이의 용도

... 본 발명은 거대단량체를 함유하는 폴리에테르-폴리실록산으로부터 수득 가능한 공중합체, 및 이의 제조 방법에 관한 것이다. 본 발명은 추가로 조성물, 예컨대 코팅 조성물 및 중합체성 성형 화합물 중 첨가제로서의 공중합체의 용도뿐만 아니라 적어도 하나의 본 발명의 공중합체를 함유하는 이러한 조성물에 관한 것이다.

PROCESSOS PARA SINTESE DE COMPOSTOS TOTAL OU SUBSTANCIALMENTE AMORFOS DE ELEMENTOS DOS GRUPOS IIIA-GRUPO VA

compostos de organossilìcio e seu uso

Composição de silicone polimérico com baixo teor de água lente de contato e método para produzir uma composição de silicone polimérico com baixo teor de água

PROCESSO PARA OBTENCAO DE COMPOSTOS,AGENTES PARA COMBATE DE PRAGAS UTILIZACAO DE TAIS COMPOSTOS,E PROCESSO PARA O COMBATE DE INSETOS PREJUDICIAIS,ACAROS OU NEMATODIOS

Processo para a preparação de organossilanos funcionalidados na posição 3

Composições com funcionalidade amÈnio quaternário à base de silìcio e métodos para a sua produção

Tellurium precursors for GST films in an ALD or CVD process

The present invention is a process of making a germanium-antimony-tellurium alloy film using a process selected from the group consisting of atomic layer deposition and chemical vapor deposition, wherein a silyltellurium precursor is used as a source of tellurium for the alloy film and is reacted with an alcohol during the deposition process.

Novel anthracene derivatives, process for preparation thereof, and organic electronic light emitting device using the same

The present invention relates to a novel anthracene derivative, a process for preparation thereof, and an organic electronic device using the same. The anthracene derivative according to the present invention can serve as a hole injecting material, a hole transporting material, an electron injecting material, an electron transporting material, or a light emitting material, and particularly as a light emitting host or dopant, especially as a green host or dopant singly, in an organic electronic device including an organic light emitting device. The organic electronic device according to the present invention exhibits excellent characteristics in efficiency, drive voltage, life time, and stability.

Controlling method of higher silane selectivity and method for forming higher silane using the same

The present invention relates to a high order silane selectivity adjustment method. More specifically, the present invention relates to a high order silane preparation method in which high value-added, high order silane, particularly tetrasilane or pentasilane, can be prepared economically and in a high yield by means of mixing two or more types of low order silane and thermally decomposing same. Moreover, the present invention enables production by means of increasing the selectivity of desired high order silane when necessary.

APPARATUS FOR GENERATING 1-METHYLCYCLOPROPENE

(meth)acrylamide monomers containing hydroxy and silicone functionalities

Fluorine-containing silicon compounds, silicone resins, resist compositions, and patterning process

Organosilicon compound

Procatalyst Composition Including Silyl Ester Internal Donor and Method

The present disclosure provides silyl esters and silyl diol esters suitable as internal electron donors in procatalysts for polymer production. Disclosed are procatalyst compositions formed from a procatalyst precursor and an internal electron donor that is a silyl ester or a silyl diol ester. The procatalyst compositions can be used with a cocatalyst and optionally an external electron donor and/or an activity limiting agent to form a Ziegler-Nana catalyst composition. The present catalyst compositions exhibit high catalyst activity and form olefin-based polymers with broad molecular weight distribution, favorable flexural modulus, and high isotacticity.

Cardanol based dimers and uses therefor

Cardanol based dimers are provided. The cardanol dimers are formed by hydrosylylation with silanes. Cardanol based dimers may be further reacted to form epoxy curing agents and epoxies which can be used as anti-fouling coatings on ship hulls and marine structures. The cardanol dimers may also be used to produce friction particles or phenolic resins. Methods of synthesizing the cardanol based dimers, the epoxy curing agents and the epoxies are also provided.

Process for the synthesis of 1,3-bis(aminoalkyl)disiloxanes

The invention provides a process for the synthesis of bis(aminoalkyl)disiloxanes of the general formula I by reaction of the carbamatosilanes of the general formula Ma or of the carbamatodisiloxanes of the general formula Mb or of mixtures thereof in the presence of water, where R 1 is a divalent hydrocarbon radical having 1 to 100 C atoms, it being possible for the carbon chain to be interrupted by non-adjacent oxygens, sulphur atoms, —NR 6 —(CO)— or —NHCONH- groups and for the hydrogens in the divalent hydrocarbon radical individually to be substituted by F, Cl, NR 7 R 8 or OR 9 groups, and R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 and R 9 are hydrocarbon radicals having 1 to 100 C atoms.

Aqueous solution of piperazinyl-containing silanol compound and making method

An aqueous solution contains a piperazinyl-containing silanol compound having formula (1) wherein R 1 is a monovalent hydrocarbon group and n is 0, 1 or 2 and a dehydrated condensate thereof, with a volatile alcohol content being less than 10 wt %.

Charge transport compositions and electronic devices made with such compositions

The present invention is directed to a photoactive device comprising an anode, a cathode, and a photoactive layer, which device further comprises an electron transport and/or anti-quenching layer which minimizes both electron transfer quenching and energy transfer quenching of the photoactive layer.

Flexible underfill compositions for enhanced reliability

Underfill materials for fabricating electronic devices are described. One embodiment includes an underfill composition including an epoxy mixture, an amine hardener component, and a filler. The epoxy mixture may include a first epoxy comprising a bisphenol epoxy, a second epoxy comprising a multifunctional epoxy, and a third epoxy comprising an aliphatic epoxy, the aliphatic epoxy comprising a silicone epoxy. The first, second, and third epoxies each have a different chemical structure. Other embodiments are described and claimed.

Photoelectric conversion element, production method thereof, photosensor, imaging device and their driving method

To provide a photoelectric conversion element capable of functioning as a photoelectric conversion element when a compound having a specific structure is applied to the photoelectric conversion element, causing the element to exhibit a low dark current, and reducing the range of increase in the dark current even when the element is heat-treated, and an imaging device equipped with such a photoelectric conversion element. A photoelectric conversion element having a photoelectric conversion film which is sandwiched between a transparent electrically conductive film and an electrically conductive film and contains a photoelectric conversion layer and an electron blocking layer, wherein the electron blocking layer contains a compound having, as a substituent, a substituted amino group containing three or more ring structures.

Phosphonate nucleosides useful as active ingredients in pharmaceutical compositions for the treatment of viral infections, and intermediates for their production

Disclosed herein are novel phosphonate nucleosides and thiophosphonate nucleosides comprising a phosphonalkoxy-substituted or phosphonothioalkyl-substituted five-membered, saturated or unsaturated, oxygen-containing or sulfur-containing ring coupled to a heterocyclic nucleobase such as a pyrimidine or purine base. The invention further relates to compounds having HIV (Human Immunodeficiency Virus) replication inhibiting properties and to compounds having antiviral activities with respect to other viruses. The invention also relates to methods for preparation of all such compounds and pharmaceutical compositions comprising them. The invention further relates to the use of said compounds as a medicine and in the manufacture of a medicament useful for the treatment of subjects suffering from HIV infection, as well as for treatment of other viral, retroviral or lentiviral infections and to the treatment of animals suffering from FIV, viral, retroviral or lentiviral infections.

Esters with Antimicrobial, Bioresistant and Fungal Resistant Properties

A bromine/nitro moiety linked into the backbone of an ester or other compound over a wide range of occurrence rates provides antimicrobial, bio-resistant and fungal resistant properties for metal working fluids (MWF)s and other coatings. The moiety can be have the bromo and nitro groups linked to the same or different carbon atoms. The present invention also relates to urethanes, urea, amides, imides, carbonates, ethers, siloxanes, and many other types of linkages essential to MWF bases.

Method for producing alkoxy-substituted 1,2-bissilylethanes

The invention relates to a method for producing alkoxy-substituted 1,2-bissilylethanes of the general formula 1 (R 1 O) n R 2 (3-n) Si—CH 2 —CH 2 —SiR 2 (3-n) (OR 1 ) n   (1), which comprises reacting, in a first step, a mixture containing compounds of the general formulae 2 and 3 Cl n R 2 (3-n) Si—CH 2 —CH 2 —SiR 2 (3-n) Cl n   (2) Cl n R 2 (3-n) Si—CH═CH—SiR 2 (3-n) Cl n   (3) with an alcohol of the general formula 4 R 1 OH  (4) and, in a second step, subjecting the resultant mixture which contains compounds of the general formula 1 and compounds of the general formula 5 (R 1 O) n R 2 (3-n) Si—CH═CH—SiR 2 (3-n) (OR 1 ) n   (5) to reductive conditions such that the compound of the general formula 5 is converted into a compound of the general formula 1, wherein R 1 and R 2 are monovalent, unsubstituted or halogen-substituted hydrocarbon radicals having 1 to 16 carbon atoms and n is the value 1, 2 or 3.

Synthesis of ttx intermediates

The present invention relates to the synthesis of intermediates which are useful in TTX synthesis and to the preparation thereof.

Hydrosilylation method, method for producing organosilicon compound, and organosilicon compound

A hydrosilylation method is provided. In this hydrosilylation method, silylation of the carbon atom other than the terminal carbon atom and generation of the by-product isomer by internal migration of the double bond are suppressed without sacrificing the hydrosilylation reactivity, even if an olefin compound having tertiary amine atom which can be a catalyst poison was used. In the hydrosilylation, an olefin compound having carbon-carbon unsaturated bond, and a compound having hydrogensilyl group are reacted in the presence of an acid amide compound, a nitrile compound and an aromatic hydroxyl compound, or an organoamine salt compound, by using catalytic action of platinum and/or its complex compound.

Trihydroxy polyunsaturated eicosanoid derivatives

The invention features methods for the preparation of naturally occurring trihydroxy polyunsaturated eicosanoids and their structural analogs. The invention further provides new derivatives and analogs of trihydroxy polyunsaturated eicosanoids that can be prepared according to these methods. The invention also provides compositions and methods using trihydroxy polyunsaturated eicosanoid derivatives for the prevention, amelioration and treatment of a variety of diseases or conditions associated with inflammation or inflammatory response, autoimmune diseases, rheumatoid arthritis, cardiovascular diseases, or abnormal cell proliferation or cancer.

Organic Semiconductors

A semiconducting compound comprising the structure: where R1 to R4 independently comprise, but are not limited to, optionally substituted straight, branched or cyclic alkyl chains having 2 to 20 (e.g. 2 to 12) carbon atoms, alkoxy, amino, amido, silyl, alkyl, alkenyl, aryl or hetero aryl; where X1 and X2 independently comprise S, O, NR5 or SiR6R7 where R8 to R7 independently comprise C1 to C5 branched, straight or cyclic alkyl chains; and where Ar1 comprises a heterocyclic ring, and where n is an integer between 1 and 4.

Novel organic electroluminescent compounds and organic electroluminescent device using the same

Provided are a novel organic electroluminescent compound and an organic electroluminescent device using the same. When used as a host material of an organic electroluminescent material of an OLED device, the organic electroluminescent compound disclosed herein exhibits good luminous efficiency and excellent life property as compared to the existing host material. Therefore, it may be used to manufacture OLEDs having very superior operation life.

6,5-heterocyclic propargylic alcohol compounds and uses therefor

The invention relates to novel compounds of Formula I: wherein A, Y, R 1 , R 2 and the subscript b each has the meaning as described herein and compounds of Formula I, and stereoisomers, geometric isomers, tautomers, solvates, metabolites, isotopes, pharmaceutically acceptable salts, or prodrugs thereof. Compounds of Formula I and pharmaceutical compositions thereof are useful in the treatment of disease and disorders in which undesired or over-activation of NF-kB signaling is observed.

Five-membered cyclocarbonate polysiloxane compound and process for preparation of same

A 5-membered cyclic carbonate polysiloxane compound is represented by the below-described formula (1), and is produced by a process that reacts an epoxy-modified polysiloxane compound with carbon dioxide. wherein A means in which R 1 means an alkylene group which has from 1 to 12 carbon atoms and may be linked via an element of O, S or N and/or —(C 2 H 4 O) b —, R 2 means a direct bond or an alkylene group having from 2 to 20 carbon atoms, R 2 may be linked to an alicyclic group or aromatic group, b stands for a number of from 1 to 300, and a stands for a number of from 1 to 300.

Nanoimprint-mold release agent, surface treatment method, and nanoimprint mold

A nanoimprint-mold release agent including an alkoxysilane compound represented by general formula (1) is provided wherein R f and R f ′ are each independently a fluoroalkyl group of 1 to 10 carbon atoms; R 1 is a hydrogen atom or an aliphatic monovalent hydrocarbon group of 1 to 6 carbon atoms; R 2 and R 3 are each independently methyl group or ethyl group; X and Y are each independently an ether linkage or an ester linkage; a and b are each 0 or 1; m, n, and p are each an integer of 0 to 6; q is an integer of 1 to 6 and r is an integer of 0 to 2.

Photocurable compound

Disclosed is a compound having a photocurable urethane(meth)acrylate group, its manufacturing method, and a photocurable composition including the compound. The compound is represented by Chemical Formulae 1 to 6. Each of Chemical Formulae 1 to 6 includes a urethane(meth)acrylate group represented by Chemical Formula 1-1 or 1-2.

Aromatic heterocyclic derivative and organic electroluminescence device using the same

An aromatic heterocyclic derivative represented by the following formula (1), a material for an organic electroluminescence device and an organic electroluminescence device including these:

Thiophene analogues for the treatment or prevention of flavivirus infections

Compounds represented by formula I: or pharmaceutically acceptable salts and solvates thereof, wherein R 1 , X, Y, and Z are as defined herein, are useful for treating flaviviridae viral infections.

Process for preparing substituted pentacenes

The invention relates to a process of preparing substituted pentacenes, to novel pentacenes prepared by this process, to the use of the novel pentacenes as semiconductors or charge transport materials in optical, electrooptical or electronic devices including field effect transistors (FETs), electroluminescent, photovoltaic and sensor devices, and to FETs and other semiconducting components or materials comprising the novel pentacenes.

3-alkoxy, thioalkyl and amino-4-amino-6-(substituted)picolinates and their use as herbicides

3-alkoxy, thioalkyl and amino-4-amino-6-(substituted)picolinic acids having a halogen, alkyl or mono-, di- tri- and tetra-substituted aryl substituents in the 6-position, and their acid derivatives, are herbicides demonstrating a broad spectrum of weed control.

Host materials for phosphorescent oleds

Novel aryl silicon and aryl germanium host materials are described. These compounds improve OLED device performance when used as hosts in the emissive layer of the OLED.

BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS

The invention relates to compounds of formula (I) 5. Silica nanoparticle claim 1 , comprising at least one photosensitizer constituted by at least a compound according to claim 1 , covalently linked to said nanoparticle claim 1 , and possibly comprising shielding moieties grafted on the surface of said nanoparticle claim 1 , and possibly comprising biotargeting moieties grafted on the surface of said nanoparticle.6. Silica nanoparticle composition claim 1 , constituted by at least one silica nanoparticle comprising at least one photosensitizer constituted by at least a compound according to claim 1 , covalently linked to said nanoparticle claim 1 , and possibly comprising shielding moieties grafted on the surface of said nanoparticle claim 1 , and possibly comprising biotargeting moieties grafted on the surface of said nanoparticle.7. Silica nanoparticle composition according to claim 6 , wherein said silica nanoparticle have an organized porosity.8. Silica nanoparticle composition according to claim 6 , wherein said silica nanoparticle is mesoporous.9. Silica nanoparticle composition according to claim 6 , comprising biotargeting moieties grafted on the surface of said nanoparticle which specifically target neoplastic tissues.10. Silica nanoparticle composition according to claim 6 , comprising shielding moieties grafted on the surface of said nanoparticle claim 6 , and which specifically absorb radiations in the 190 to 600 nm range claim 6 , particularly in the 250 to 500 nm wavelengths.11. Silica nanoparticle composition according to claim 6 , wherein the concentration of said photosensitizer claim 6 , with respect to the total mass of the nanoparticle comprising said photosensitizer claim 6 , ranges from about 0.1 micromole per gram to about 100 micromoles per gram claim 6 , particularly ranges from about 0.5 micromoles per gram to about 30 micromoles per gram claim 6 , particularly ranges from about 1 micromoles per gram to about 10 micromoles per gram.12. ...

NOVEL ORGANIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE SAME

Provided are a novel organic compound appropriate for emission of green light and an organic light-emitting device including the organic compound. Provided is a substituted or unsubstituted indeno[1,2,3-cd]naphtho[2,3-k]fluoranthene appropriate for emission of green light. The substituents of the indeno[1,2,3-cd]naphtho[2,3-k]fluoranthene are each independently selected from a hydrogen atom, a halogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted alkoxy group, a substituted amino group, a substituted or unsubstituted aryl group, and a substituted or unsubstituted heterocyclic group. 2. The organic compound according to claim 1 , wherein Rto Rare each independently selected from a hydrogen atom and a substituted or unsubstituted aryl group.4. An organic light-emitting device comprising:an anode;a cathode; and{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'an organic compound layer disposed between the anode and the cathode, the organic compound layer containing the organic compound according to .'}5. An organic light-emitting device comprising:an anode;a cathode; and{'claim-ref': {'@idref': 'CLM-00003', 'claim 3'}, 'an organic compound layer disposed between the anode and the cathode, the organic compound layer containing the organic compound according to .'}6. The organic light-emitting device according to claim 4 , wherein the organic compound layer is a light-emitting layer.7. The organic light-emitting device according to claim 6 , wherein the organic light-emitting device emits green light.8. A display apparatus having a plurality of pixels claim 4 , each including the organic light-emitting device according to and a switching device connected to the organic light-emitting device.9. An image input apparatus comprising:an image input unit configured to input an image; and{'claim-ref': {'@idref': 'CLM-00004', 'claim 4'}, 'a display unit configured to display the image, the display unit having a plurality of pixels, each ...

Alkynyl-substituted indenofluorenes useful in electronic and electro-optical devices

Indenofluorenes that include at least two alkynyl-containing substituents.

METHOD OF MAKING COUPLED HETEROARYL COMPOUNDS VIA REARRANGEMENT OF HALOGENATED HETEROAROMATICS FOLLOWED BY OXIDATIVE COUPLING

The inventions disclosed and described herein relate to new and efficient generic methods for making a wide variety of compounds having Formulas (I) and (II) as shown below (Formulas (I) and (II)) wherein HAr is an optionally substituted five or six membered heteroaryl ring, and Hal is a halogen, and Y is a bridging radical, such as S, Se, NRC(O), C(O)C(O), Si(R), SO, SO, PR, BR, C(R)or P(O)R. The synthetic methods employ a “Base-Catalyzed Halogen Dance” reaction to prepare a metallated compound comprising a five or six membered heteroaryl ring comprising a halogen atom, and then oxidatively coupling the reactive intermediate compound. The compounds of Formula (II) and/or oligomer or polymers comprising repeat units having Formula (II) can be useful for making semi-conducting materials, and/or electronic devices comprising those materials. 2. The method of wherein Hal is Br or I.3. The method of wherein HAr is an optionally substituted five membered heteroaryl ring.87. The method of any one of - wherein Ris a C-Caryl or heteroaryl optionally substituted by one to four ring substituents independently selected from halides claims 4 , alkyl claims 4 , alkynyl claims 4 , perfluoroalkyl claims 4 , alkoxide claims 4 , perfluoroalkoxide claims 4 , —Sn(R) claims 4 , —Si(R) claims 4 , —Si(OR)or —B(—OR)wherein each Ris an independently selected alkyl or aryl claims 4 , and each Ris an independently selected alkyl or aryl claims 4 , or the Rgroups together form an optionally substituted alkylene group to form a ring bridging the oxygen atoms.1110. The method of any one of - wherein the strongly basic compound is an alkyl lithium compound.1210. The method of any one of - wherein the strongly basic compound is a lithium dialkylamide compound.1310. The method of any one of - wherein the oxidizing agent is a Cu(II) salt.1410. The method of any one of - wherein the bishalo-bisheteroaryl compound is a 2 claims 1 ,2′-bishalo-1 claims 1 ,1′-bisheteroaryl compound.21. The method of ...

Hydrophilic Polyorganosiloxanes

The invention relates to glycerol-modified polyorganosiloxane compounds with high hydrophilicity and their use. 115-. (canceled)18. The polyorganosiloxane compounds according to claim 16 , wherein the compounds of the formula (I) comprise two or more residues R.24. The polyorganosiloxane compounds according to claim 16 , wherein the compounds of the formula (I) claim 16 , in relation to the total amount of the siloxy units claim 16 , comprise at least 25 mol-% siloxy units claim 16 , which comprise residues R.25. The polyorganosiloxane compounds according to claim 16 , wherein the molar ratio of the residues Rto the glycidol units in the obtained polyorganosiloxane compounds is at least 1:5.26. The polyorganosiloxane compounds according to claim 16 , which comprise at least 8 mmol hydroxyl groups per gram of the polysiloxane compound.29. A method for the preparation of the polyorganosiloxane compounds according to claim 16 , comprising reacting compounds of the formula (I) with more than 1 mol glycidol compounds of the formula (II) per residue R.301. A use of the polyorganosiloxane compounds obtained in accordance to claim asemulsifier,defoaming agent,coagulant for rubber latexes,phase separating agent in crude oil extraction,hydrophilization additive,wetting agent and adjuvant in plant protection emulsions,anti-static agent,anti-fogging coating,hydrogen-forming additive in Si—H group-containing compositions,fiber treatment agent,foam stabilizer, in particular for rigid and flexible polyurethane foams, orcross-linking component in the production of elastomers or elastomeric foams.31. The polyorganosiloxane compounds according to claim 19 , wherein claim 19 ,f=1 to 100,g=10 to 200,h=i=l=0, andf+g+h+i+j+k+l=10 to 200.32. The polyorganosiloxane compounds according to claim 16 , wherein claim 16 ,f=1 to 50,g=10 to 150,h=i=l=0, andf+g+h+i+j+k+l=10 to 150. The invention relates to hydrophilic polyorganosiloxane compounds prepared by reacting functionalized ...

Mobile Self-Spreading Biocides

A compound having the formula: Each R 1 is C 1 -C 3 alkyl group or fluoridated C 1 -C 3 alkyl group. The value n is a positive integer. Each R 2 is alkylene group or polyethylene glycol group. Y 1 is hydrogen, quaternary ammonium containing group, or phenol-containing group. Y 2 is quaternary ammonium-containing group or phenol-containing group. The quaternary ammonium-containing group is non-aromatic and contains no more than one quaternary ammonium.

HIGH-MOBILITY STRUCTURES, APPARATUSES AND METHODS THEREFOR

Various apparatuses, systems and methods involve high mobility materials. In accordance with one or more example embodiments, a material includes a conjugated molecule and a side chain bonded to the conjugated molecule. The side chain includes at least one of a siloxane-terminated unit and a derivative of a siloxane-terminated unit that enhance solubility of the conjugated molecule. Further, the side chain facilitates a π-stacking distance between the conjugated molecules when stacked (e.g., in an organic semiconductor film), thereby facilitating carrier mobility between the conjugated molecules 1. A material comprising:conjugated molecules; andfor each conjugated molecule, a side chain bonded to the conjugated molecule and including at least one of a siloxane-terminated unit and a derivative of a siloxane-terminated unit configured and arranged to enhance solubility of the conjugated molecule and to set a π-stacking distance between the conjugated molecules that facilitates carrier mobility between the conjugated molecules.2. The material of claim 1 , wherein the conjugated molecules are stacked in an organic semiconductor film having a carrier mobility set via the π-stacking distance claim 1 , the side chain being configured and arranged with a branching region relative to the conjugated molecule that sets the π-stacking distance.3. The material of claim 1 , wherein the side chain includes a linear spacer configured and arranged to couple the at least one of the siloxane-terminated unit and the derivative of the siloxane-terminated unit to the conjugated molecule.4. The material of claim 1 , wherein the side chain is configured and arranged to couple to the conjugated molecules to facilitate π-stacking distance between the conjugated molecules that is shorter than π-stacking distance of at least one of highly-branched 1-ethylhexyl and highly-branched 1-hexyldecyl.5. The material of claim 1 , wherein the side chain is configured and arranged to couple to the ...

INSECTICIDAL COMPOUNDS

The invention relates to compounds of formula (I) where A, A, A, A, G, R, R, Rand Rare as defined in claim 1; or a salt or JV-oxide thereof. Furthermore, the present invention relates to processes and intermediates for preparing compounds of formula (I), to insecticidal, acaricidal, nematicidal and molluscicidal compositions comprising the compounds of formula (I) and to methods of using the compounds of formula (I) to control insect, acarine, nematode and mollusc pests. 2. A compound according to where Ais C—R claim 1 , Ais C—H claim 1 , Ais C—H or nitrogen and Ais C—H or nitrogen;3. A compound according to or where G is oxygen.4. A compound according to any one of to where Ris hydrogen claim 1 , methyl claim 1 , ethyl claim 1 , methylcarbonyl- claim 1 , or methoxycarbonyl-.6. A compound according to any one of to where Ris chlorodifluoromethyl or trifluoromethyl.7. A compound according to any one of to where Ris phenyl or phenyl substituted by one to five R.11. A method of controlling insects claim 1 , acarines claim 1 , nematodes or molluscs which comprises applying to a pest claim 1 , to a locus of a pest claim 1 , or to a plant susceptible to attack by a pest an insecticidally claim 1 , acaricidally claim 1 , nematicidally or molluscicidally effective amount of a compound of formula (I) as defined in any one of to .12. An insecticidal claim 1 , acaricidal claim 1 , nematicidal or molluscicidal composition comprising an insecticidally claim 1 , acaricidally claim 1 , nematicidally or molluscicidally effective amount of a compound of formula (I) as defined in any one of to .13. An insecticidal claim 12 , acaricidal claim 12 , nematicidal or molluscicidal composition according to comprising an additional compound having biological activity.14. A method of treatment of insect pests in or on animals claim 12 , comprising administering an effective amount of a compound as defined in any one of to claim 12 , or a composition comprising said compound claim 12 , to an ...

HYDROLYSIS-RESISTANT SILICONE COMPOUNDS

In one aspect, the invention relates to hydrolysis-resistant silicone compounds. In particular, disclosed are sterically hindered hydrolysis-resistant silicone compounds and improved purity hydrolysis-resistant silicone compounds. Also disclosed are processes for making hydrolysis-resistant silicone compounds; the products of the disclosed processes; compositions and polymers comprising the disclosed compounds and products of the disclosed processes; and ophthalmic lenses, for example contact lenses, intraocular lenses, artificial cornea, and spectacle lenses, comprising the disclosed compositions, disclosed polymers, disclosed compounds, and products of the disclosed processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. 2. The process of claim 1 , wherein M is an acryloyloxy group claim 1 , a methacryloyloxy group claim 1 , acrylamide group claim 1 , methacrylamide group claim 1 , N-vinylamide group claim 1 , or styryl group.3. The process of claim 2 , wherein M is an acryloyloxy group or a methacryloyloxy group.5. The process of claim 1 , wherein Q claim 1 , Q claim 1 , and Qindependently represent alkyl.10. The process of claim 9 , wherein M is an acryloyloxy group claim 9 , a methacryloyloxy group claim 9 , acrylamide group claim 9 , methacrylamide group claim 9 , N-vinylamide group claim 9 , or styryl group.11. The process of claim 10 , wherein M is an acryloyloxy group or a methacryloyloxy group13. The process of claim 12 , wherein 1≦3k+m≦20.15. The process of claim 14 , wherein M is an acryloyloxy group claim 14 , a methacryloyloxy group claim 14 , acrylamide group claim 14 , methacrylamide group claim 14 , N-vinylamide group claim 14 , or styryl group.16. The process of claim 15 , wherein M is an acryloyloxy group or a methacryloyloxy group18. The process of claim 17 , wherein 1≦3k+m≦20. This application is a divisional of U.S. Nonprovisional ...

EPOXYSILICONE CONDENSATE, CURABLE COMPOSITION COMPRISING CONDENSATE, AND CURED PRODUCT THEREOF

There is provided an epoxy group-containing silicone condensate that yields cured products with excellent transparency, thermal resistance and gas barrier properties. An epoxysilicone condensate which is the product of hydrolytic condensation of an epoxy group-containing alkoxysilane compound represented by formula (1): 2. The epoxysilicone condensate according to claim 1 , wherein Rto Rin formula (1) are all hydrogen.3. A curable composition comprising the epoxysilicone condensate according to .4. A cured product of the curable composition according to .5. An optical element comprising the cured product according to as an encapsulant.6. An electronic component comprising the cured product according to as an encapsulant.7. A curable composition comprising the epoxysilicone condensate according to .8. A cured product of the curable composition according to .9. An optical element comprising the cured product according to as an encapsulant.10. An electronic component comprising the cured product according to as an encapsulant. The present invention relates to an epoxysilicone condensate with an alicyclic epoxy group in the molecule, a curable composition comprising the condensate, and a cured product thereof.Epoxy resins have been commonly used in the past as encapsulants for light emitting diode (LED) elements and semiconductor chips, from the viewpoint of adhesion with the substrates on which such parts are mounted, as well as toughness and gas barrier properties.When epoxy resins are used as encapsulants, however, the thermal resistance and light resistance of such resins being inadequate, coloration of the encapsulant is observed with blue and white LEDs that have high heat release and light energy, and thus the performance of such LED elements is significantly reduced.Much research is therefore being conducted on the use of silicone resins with excellent thermal resistance and light resistance, as LED encapsulants (see Patent Documents 1 and 2, for example). ...

WATER-SOLUBLE ORGANOSILICONATE POWDER

Organosilanolate powders having a low cation to silicon ratio provide superior hydrophobing ability. The powders may be prepared on an industrial scale by hydrolysis of a silane with a basic salt solution, adding an inert organic solvent, and removing gaseous or alcoholic hydrolysis products by evaporation or distillation, precipitating the organosilanolate as a fine powder. 114.-. (canceled)15. A powder comprising at least one salt of at least one organosilanol , of the hydrolysis/condensation products thereof , or of at least one organosilanol together with the hydrolysis/condensation products thereof , wherein cations of the at least one salt are selected from the group consisting of alkali metal ions , ammonium ions , organoammonium ions and mixtures thereof , wherein the molar ratio of cation to silicon is from 0.1 to 0.89.17. The process of claim 16 , in which the first step is carried out in the absence of the inert liquid F claim 16 , and in simultaneously implemented second and third steps claim 16 , the siliconate salt solution thus formed is contacted with the inert liquid F under conditions in which the volatile constituents of the solution evaporate and the siliconate salt is precipitated in the form of a solid.18. The process of claim 16 , in which the basic salts are selected from sodium hydroxide and potassium hydroxide.19. The process of claim 17 , in which the basic salts are selected from sodium hydroxide and potassium hydroxide.20. The process of claim 16 , in which hydrocarbons are used as inert liquid F.21. An organosilanolate powder produced by the process of .22. The powder of claim 15 , which has a water solubility of at least 20% by weight at 20° C.23. The powder of claim claim 15 , 21 which has a water solubility of at least 20% by weight at 20° C.24. The powder of claim 15 , which has an average particle size of not more than 500 μm.25. The powder of claim 21 , which has an average particle size of not more than 500 μm.26. The process of ...

SILICONE-MODIFIED WAX, COMPOSITION AND COSMETIC PREPARATION CONTAINING THE SAME, AND PRODUCTION METHOD OF SILICONE-MODIFIED WAX

The present invention provides a silicone-modified wax obtained by subjecting an esterification reaction product obtained from a polyhydric alcohol having one or two alkenyl groups in one molecule and a higher fatty acid, and an organohydrogenpolysiloxane containing at least one methyl group, to a hydrosilylation reaction; wherein the silicone-modified wax is solid or in a grease state exhibiting a thixotropy, at 25° C. There can be a silicone-modified wax, a production method thereof, and a composition and a cosmetic preparation each containing the silicone-modified wax, which silicone-modified wax is solid or in a grease state exhibiting a thixotropy, at 25° C., and is high in compatibility with oil-based agents such as volatile and nonvolatile silicone oils, hydrocarbon oils, ester oils, natural animal oils and plant oils, and the like. 1. A silicone-modified wax obtained by subjecting an esterification reaction product obtained from a polyhydric alcohol having one or two alkenyl groups in one molecule and a higher fatty acid , and an organohydrogenpolysiloxane containing at least one methyl group , to a hydrosilylation reaction;wherein the silicone-modified wax is solid or in a grease state exhibiting a thixotropy, at 25° C.3. The silicone-modified wax according to claim 1 , wherein the silicone-modified wax has a melting point between 40° C. and 100° C.4. The silicone-modified wax according to claim 2 , wherein the silicone-modified wax has a melting point between 40° C. and 100° C.5. A composition containing the silicone-modified wax according to in an amount between 5 and 40 mass % claim 1 , wherein the composition is in a paste state or solid state at 25° C. and at an ordinary pressure.6. A composition containing the silicone-modified wax according to in an amount between 5 and 40 mass % claim 2 , wherein the composition is in a paste state or solid state at 25° C. and at an ordinary pressure.7. A composition containing the silicone-modified wax according to ...

SYNTHESIS OF SILYL ACETYLENES

The present disclosure provides a method of preparing silylethynyl compounds in which two of the hydrocarbyl groups bonded to the silicon exclusive of the ethynyl group, are the same and one is different, that may be used in preparing novel silylethynyl functionalized acene semiconductor chromophores. 2. The process of claim 1 , where each of Rand Rare selected from alkyl claim 1 , alkyl claim 1 , alkenyl claim 1 , cycloalkyl and aryl claim 1 , or combinations thereof.3. The process of where Ris H— claim 1 , and R-≡-M is generated in situ by contacting acetylene with an alkyl lithium compound.4. The process of claim 1 , where the transition metal bromination catalyst is a Group 10 transition metal halide and the aliphatic bromo compound is an alkyl- or allyl bromide.5. The process of wherein said transition metal halide is PdClor NiCl.9. The process of claim 1 , where Ris an acetylene protecting group claim 1 , and step of removing the protecting group comprises contacting the product of step c) with alcoholic base or fluoride ion.10. The process of claim 1 , where Ris (CH)—Si—.11. The process of where said step of removing the protecting group Rcomprises treatment with alcoholic base. This application claims the benefit of U.S. Provisional Patent Application No. 61/349,380, filed May 28, 2010, the disclosure of which is incorporated by reference herein in its entirety.Acenes, as a class of graphite substructures, are particularly attractive targets in the synthesis of organic semiconductors because of their demonstrated high mobilities, strong intermolecular coupling and small reorganization energies. The usefulness of acene oligomers such as pentacenes are already showing in numerous electronics applications including, but not limited to, thin-film transistors (display technologies), photovoltaic cells and light-emitting diodes.Substituted acenes have received limited attention due to their synthetic inaccessibility. More specifically, while the properties and ...

SILAFLUORENE METALLOPORPHYRIN- BENZENE ORGANIC SEMICONDUCTOR MATERIAL AND PREPARING METHOD AND USES THEREOF

A silafluorene metalloporphyrin-benzene organic semiconductor material and preparing method and uses thereof are provided. The structure of the silafluorene metalloporphyrin-benzene organic semiconductor material is defined by structure formula (I); wherein: n is an integer between 1 and 100, R, R, R, Rare H, alkyl with C-C, phenyl, alkyl benzene or alkoxyl benzene containing one or more C-C, M is a metal ion. The silafluorene metalloporphyrin-benzene organic semiconductor material has good solubility, high carrier mobility, strong absorbance, wide absorbent range to light and elevated utilization ratio of solar light. Besides, the process of the preparing method is simple and easy to operate and control. 2. The silafluorenyl metalloporphyrin-benzene organic semiconductor material according to claim 1 , wherein said metal ion is Zn claim 1 , Cu claim 1 , Fe claim 1 , Co claim 1 , Cd claim 1 , Pt claim 1 , Zr claim 1 , Mn claim 1 , Ni claim 1 , Pb or Sn.4. The preparing method according to claim 3 , wherein claim 3 , in said step S1 claim 3 , molar ratio of said dipyrromethane claim 3 , the first silafluorene derivative and the second silafluorene derivative is a:(b+c)=1:1 claim 3 , where a≧b>0 claim 3 , and c≧0; said the first catalyst is propionic acid claim 3 , trifluoroacetic acid; said oxidant is 2 claim 3 ,3-dichloro-5 claim 3 ,6-dicyano-1 claim 3 ,4-benzoquinone; said the first organic solvent is one or two of trichloromethane and dichloromethane.5. The preparing method according to claim 3 , wherein claim 3 , in said step S2 claim 3 , the molar ratio of used said silafluorenyl porphyrin derivative to used said brominating agent is in the range of 1:2 to 1:5; said brominating agent is N-bromobutanimide; said the second organic solvent is at least one of tetrahydrofuran claim 3 , chloroform claim 3 , dimethylformamide and orthodichlorobenzene.6. The preparing method according to claim 3 , wherein claim 3 , in said step S3 claim 3 , molar ratio of said dibromo- ...

NEW ROUTE TO SYNTHETIC ANALOGUES OF ROCAGLAMIDE AND AGLAFOLINE USING CASCADE TRANSFORMATIONS INITIATED BY OXY-COPE REARRANGEMENT OF BIS-ALKYNES

A method for preparing a cyclobutene compound or a cyclopentenone is provided. The method comprises contacting an α,β-diketone with a metal acetylide at a temperature below 0° C. to thereby form a reaction mixture comprising a bis-alkyne precursor. The bis-alkyne precursor rearranges into a bis-allenic intermediate, which undergoes further rearrangement into the cyclobutene compound or the cyclopentenone compound as the temperature of the reaction mixture increases from below 0° C. to above 0° C. 1. A method of preparing a cyclobutene compound , the method comprising:contacting an α,β-diketone with a metal acetylide at a temperature below 0° C. to thereby form a reaction mixture comprising a bis-alkyne precursor;wherein the bis-alkyne precursor rearranges into a bis-allenic intermediate, which undergoes further rearrangement into the cyclobutene compound as the temperature of the reaction mixture increases from below 0° C. to above 0° C.2. The method of wherein the α claim 1 ,β-diketone and the metal acetylide are contacted at a temperature below about −50° C.3. The method of wherein the rearrangement occurs as the temperature of the reaction mixture increases from about −78° C. to room temperature.4. The method of wherein the α claim 1 ,β-diketone is contacted with the metal acetylide at a molar ratio of metal acetylide to α claim 1 ,β-diketone of at least 1.9:1.6. The method of wherein the moiety comprising the silyl functional group is selected from the group consisting of trimethylsilyl claim 5 , triethylsilyl claim 5 , tri-isopropylsilyl claim 5 , and combinations thereof.8. The method of wherein the moiety comprising the silyl functional group is selected from the group consisting of trimethylsilyl claim 7 , triethylsilyl claim 7 , tri-isopropylsilyl claim 7 , and combinations thereof.13. The method of wherein the moiety comprising the silyl functional group is selected from the group consisting of trimethylsilyl claim 12 , triethylsilyl claim 12 , tri- ...

Analyte sensor

Matrix materials, such as sol-gels and polymers derivatives to contain a redox active material can be used to form electrodes and probes suitable for use in pH meters and other analyte sensing devices.

METHOD OF MANUFACTURING HYDROPHILIC SILICONE PREPOLYMER

A method for manufacturing a hydrophilic silicone prepolymer is disclosed. The method comprises ring-opening polymerization (ROP) of cyclosiloxanes, hydrosilylation of polysiloxanes, copolymerization, and end-capping reaction. After the above processes, the hydrophilic silicone prepolymer can be obtained. 1. A method for manufacturing a hydrophilic silicone prepolymer , comprising the steps of:performing a ring-opening polymerization, wherein a cyclic siloxane and a cyclic hydrogen siloxane are catalyzed by a strong acid, and then inserted into a hydroxyl-terminated disiloxane, so as to form a hydroxyl-terminated polysiloxane containing multi silicon-hydrogen (Si—H) groups;performing a hydrosilation, wherein a carbon-carbon double bond of a hydrophilic monomer is added to the Si—H groups of the polysiloxane by a rhodium-based catalyst, and then the hydrophilic monomer is connected to the polysiloxane to form a hydroxyl-terminated silicone diol containing a hydrophilic side-chain, in which the hydrophilic monomer is an amide-containing hydrophilic monomer or a phosphorylcholine-containing hydrophilic monomer;performing a copolymerization, wherein p mole of the silicone diol produced under the hydrosilation is polymerized with q mole of a diisocyanate in a different molar ratio by a catalyst of dibutyltin dilaurate (DBTDL), so as to form a diol copolymer end-capped with hydroxyl groups as p>q or form an isocyanate copolymer end-capped with isocyanate groups as p Подробнее

DEFOAMER COMPOSITIONS FOR BUILDING-PRODUCT MIXTURES

The present application relates to compositions comprising at least one siloxane and at least one superplasticizer based on polycarboxylate ethers or sulphonates of lignin, melamine or naphthalene or of resins thereof, and to the use of such compositions as or in building-product mixtures or building products, especially mortar mixtures or concrete mixtures. 4. The composition according to claim 1 , wherein a mass fraction of siloxanes of formula (I) based on a total mass fractions of siloxanes of formula (I) and of superplasticizers is from 0.01 to 10%.5. The composition according to claim 1 , further comprising a binder.6. The composition according to claim 5 , wherein said composition is a building-product mixture.7. The composition according to claim 6 , wherein said building-product mixture is at least one of a mortar mixture or a concrete mixture.8. A method of preparing a building-product mixture comprising adding the composition according to to a binder.9. The composition according to claim 1 , wherein{'sup': '3', 'claim-text': [{'br': None, 'sub': 2', '2', '2', '2', '2', 'x', '2', '2', 'y', 'z, '—CH—CH—CH—O—(CH—CHO—)—(CH—C(R′)O—)—(SO)—R″'}, {'br': None, 'sub': 2', '2', '2', '2', 'x', '2', '2', 'y, '—CH—CH—O—(CH—CHO—)—(CH—C(R′)O—)—R″'}, 'where', 'x=0 to 100,', 'y=0 to 100,', 'z=0 to 100,, 'Rindependently represents alike or unalike radicals from the group comprising'}{'sup': '3', 'with the proviso that x may be alike or unalike y and at least one of the Rradicals has x being not less than y.'}10. The composition according to claim 1 , wherein R′ is substituted with at least one of a haloalky radical and haloaryl radical selected from the group consisting of para-chlorophenyl or Cl—CH— radicals.11. The composition according to claim 1 , wherein R′ is a hydrocarbon radial selected from the group consisting of a CH═CH—CH—O—CH— radical and a methyl group.12. The composition according to claim 3 , wherein Rrepresents ethylene or propylene.13. The composition ...

AMINOTETRALINE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY

The present invention relates to aminotetraline derivatives of the formula (I) 4. Compound as claimed in claim 1 , wherein Ris hydrogen claim 1 , halogen or C-C-alkoxy.6. Compound as claimed in claim 1 , wherein Ris hydrogen or C-C-alkyl.8. Compound as claimed in claim 1 , wherein Ris hydrogen claim 1 , C-C-alkyl claim 1 , C-C-cycloalkyl-C-C-alkyl claim 1 , halogenated C-C-alkyl claim 1 , amino-C-C-alkyl claim 1 , CHCN claim 1 , —CHO claim 1 , C-C-alkylcarbonyl claim 1 , (halogenated C-C-alkyl)carbonyl claim 1 , C-C-arylcarbonyl claim 1 , C-C-alkoxycarbonyl claim 1 , C-C-aryloxycarbonyl claim 1 , —C(═NH)NH claim 1 , —C(═NH)NHCN claim 1 , C-C-alkylsulfonyl claim 1 , amino claim 1 , —NO or C-C-heterocyclyl.9. Compound as claimed in claim 1 , wherein Ris hydrogen or C-C-alkyl.10. Compound as claimed in claim 1 , wherein R claim 1 , Rtogether are optionally substituted C-C-alkylene claim 1 , wherein one —CH— of C-C-alkylene may be replaced by an oxygen atom.11. Compound as claimed in claim 1 , wherein Xis CRR.12. Compound as claimed in claim 11 , wherein Xis a bond.13. Compound as claimed in claim 1 , wherein Ris hydrogen or C-C-alkyl and Ris hydrogen or C-C-alkyl.14. Compound as claimed in claim 1 , wherein R claim 1 , Rtogether are optionally substituted C-C-alkylene.15. Compound as claimed in claim 1 , wherein Ris optionally substituted aryl or optionally substituted C-C-cycloalkyl.17. Compound as claimed in claim 1 , wherein n is 1.18. Compound as claimed in claim 1 , which is:7-Amino-8-(3,4-dichlorobenzyl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile;7-Amino-8-(4-chlorobenzyl)-5,6,7,8-tetrahydronaphthalene-2-carbonitrile;Ethyl [7-cyano-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate;tert-Butyl [7-cyano-1-(3,4-dichlorobenzyl)-1,2,3,4-tetrahydronaphthalen-2-yl]carbamate,or a physiologically tolerated salt thereof.19. A pharmaceutical composition comprising a carrier and a compound of .20. A method for treating a neurologic or psychiatric disorder ...

Surface Modified Nanoparticles

Surface-modified nanoparticles are produced by associating ligand interactive agents with the surface of a nanoparticle. The ligand interactive agents are bound to surface modifying ligands that are tailored to impart particular solubility and/or compatibility properties. The ligand interactive agents are crosslinked via a linking/crosslinking agent, such as hexamethoxymethylmelamine or a derivative thereof. The linking/crosslinking agent may provide a binding site for binding the surface modifying ligands to the ligand interactive agents.

Diarylamine-based fluorogenic probes for detection of peroxynitrite

Provided herein are improved fluorogenic compounds and probes that can be used as reagents for measuring, detecting and/or screening peroxynitrite. The fluorogenic compounds of the invention can produce fluorescence colors, such as green, yellow, red, or far-red. Also provided herein are fluorogenic compounds for selectively staining peroxynitrite in the mitochondria of living cells. Provided also herein are methods that can be used to measure, directly or indirectly, the presence and/or amount of peroxynitrite in chemical samples and biological samples such as cells and tissues in living organisms. Also provided are high-throughput screening methods for detecting or screening peroxynitrite or compounds that can increase or decrease the level of peroxynitrite in chemical and biological samples.

SILOXANE POLYETHER COPOLYMERS

The present invention is related to the preparation and use of moderately cross-linked (chin-extended), reverse (or “inverted”) surfactants, wherein the reverse surfactants comprise a polyether backbone with oligomeric or polymeric silicon-containing substitutions along the backbone. The present invention further describes crosslinked versions of the inverted surfactants, reaction products of alkenyl (allyl, vinyl, methallyl) functional copolymers (polyethers), silicone hydrides and cross-linking agents, which may be optionally reacted with water to react the remaining alkoxy groups. The crosslinking agent contains either SiH or Si-alkoxy groups or both. The compounds of the present invention exhibit only moderate cross-linking in order to be soluble or dispersible in appropriate solvents. 2. The copolymer composition of where{'sup': '1', 'sub': '3', 'Ris selected from —OH, —OC(O)CHor a monovalent hydrocarbon radical, optionally containing heteroatoms and hydroxyl groups, having from about 1 to about 30 carbon atoms;'}{'sup': '2', 'Ris a trivalent hydrocarbon radical optionally containing heteroatoms and hydroxyl groups, having from about 3 to about 30 carbon atoms;'}{'sup': '3', 'sub': '3', 'Ris selected from hydrogen, a —C(O)CHgroup or a monovalent hydrocarbon radical optionally containing heteroatoms and hydroxyl groups, having from about 1 to about 30 carbon atoms;'}{'sup': 4', '5', '6', '7', '8', '9', '10', '11', '12', '13, 'R, R, R, R, R, R, R, Rand Rare each independently selected from the group of ORor monovalent hydrocarbon radicals, optionally containing heteroatoms and hydroxyl groups, having from about 1 to about 15 carbon atoms;'}{'sup': '13', 'Ris selected from the group of H or monovalent hydrocarbon radicals optionally containing heteroatoms and hydroxyl groups, having from about 1 to about 15 carbon atoms.'}3. The copolymer composition of where{'sup': '1', 'sub': '3', 'Ris selected from —OH, —OC(O)CHor a monovalent hydrocarbon radical, optionally ...

CYCLIZATION METHODS

The invention provides methods for cyclizing poly-yne compounds under mild conditions to provide cyclic compounds. 1. A method comprising cyclizing a tri-yne compound at a temperature below about 300° C. to provide a polycyclic compound.2. A method comprising cyclizing a nonaromatic compound comprising at least three alkyne groups at a temperature below about 300° C. to provide a polycyclic compound.3. A method comprising cyclizing a first compound that comprises two or more alkyne groups with a second compound that comprises at least one alkyne group at a temperature below about 300° C. to provide a cyclic compound.5. The method of wherein W comprises 2 claim 4 , 3 claim 4 , 4 claim 4 , or 5 alkyne groups.6. The method of wherein W comprises 2 or 3 alkyne groups.7. The method of wherein X is a linking group that comprises 2-20 carbon atoms and at least one severable group.8. The method of wherein X is a linking group that comprises 2-10 carbon atoms and at least one severable group.9. The method of wherein the severable group is selected from an ester claim 4 , an amide claim 4 , a carbonate claim 4 , a carbamate claim 4 , an ether claim 4 , a silylether claim 4 , an alkene claim 4 , a urea claim 4 , a sulfide claim 4 , a disulfide claim 4 , a borate ester claim 4 , a borinate ester claim 4 , an aluminate ester claim 4 , a silicate ester claim 4 , a hydrazine claim 4 , an azo moiety claim 4 , a sulfone claim 4 , a phosphate ester claim 4 , and a phosphonate ester.10. The method of wherein X is a non-aromatic linking group that comprises 2-20 carbon atoms.11. The method of wherein X is a non-aromatic linking group that comprises 2-10 carbon atoms.12. The method of wherein Y comprises 1 claim 4 , 2 claim 4 , 3 claim 4 , or 4 alkyne groups.13. The method of wherein Y comprises 1 or 2 alkyne groups.14. The method of wherein Y has only 1 or 2 alkyne group.15. The method of further comprising contacting the polycyclic compound or the cyclic compound with a benzyne ...

USE OF SILANE AND SILOXANE BIS(BIPHENYL) TRIAZINE DERIVATIVES AS UV ABSORBERS

Disclosed is the use of silane and siloxane bis(biphenyl)triazine derivatives of formula (1), wherein n is a number from 1 to 4; if n=1, X is *-L-Sil; or a radical of formula (11′), L is a linker selected from a radical of formula (2); R, R, Rindependently from each other are C-Calkyl; C-Caryl; C-Calkoxy; or O—C-Caryl; R, R, Rand Rindependently from each other are hydrogen; C-Calkyl; C-Caryl; C-Calkoxy; or O—C-Caryl; b is a number from 0 to 30; c is a number from 0 to 6; and d is a number from 0 to 1; p is a number from 1 to 250; q is a number from 0 to 250; and Sil, Siland Silindependently from each other are a silane-, oligosiloxane or polysiloxane moiety; if n=2, X is a bivalent radical of formula (1a); or (1b); x is a number from 2 to 250; y is a number from 0 to 250; and z is a number from 1 to 50; if n=3, X is a trivalent radical containing a silane-, oligosiloxane or polysiloxane moiety; If n=4, X is a tetravalent radical of formula (1c); and A is a radical of formula (111′) as UV absorbers. 3. The method according to claim 1 , wherein Sil claim 1 , Siland Silindependently from each other are an oligosiloxane moiety selected from Si(R)[OSi(R)]; whereinm is 0; 1; or 2,o is 3, 2 or 1;the sum of m and o are 3; and{'sub': 1', '2', '1', '22', '6', '20', '1', '22', '6', '20, 'Rand Rindependently form each other are C-Calkyl; C-Caryl; C-Calkoxy; or O—C-Caryl.'}4. The method according to claim 1 , wherein the silane groups are selected from trimethylsilane claim 1 , triethylsilane claim 1 , tripropylsilane claim 1 , triisopropylsilane claim 1 , dimethyl tert-butylsilane claim 1 , dimethylhexylsilane claim 1 , triphenylsilane and dimethylphenylsilane.5. The method according to claim 1 , wherein in formula (2){'sub': 4', '5', '1', '22, 'Rand R, independently from each other are hydrogen; or C-Calkyl;'}b is a number from 1 to 30; andc and d are 0.6. The method according claim 5 , wherein in formula (2){'sub': 4', '5', '1', '5, 'Rand R, independently from each other are ...

Asymmetric biofunctional silyl monomers and particles thereof as prodrugs and delivery vehicles for pharmaceutical, chemical and biological agents

Asymmetric bifunctional silyl (ABS) monomers comprising covalently linked pharmaceutical, chemical and biological agents are described. These agents can also be covalently bound via the silyl group to delivery vehicles for delivering the agents to desired targets or areas. Also described are delivery vehicles which contain ABS monomers comprising covalently linked agents and to vehicles that are covalently linked to the ABS monomers. The silyl modifications described herein can modify properties of the agents and vehicles, thereby providing desired solubility, stability, hydrophobicity and targeting.

PROCESS FOR PREPARING 2-HYDROXYPHENYL BENZOTRIAZOLE SILOXANE COMPOUNDS

A process for preparing a siloxane compound comprising a 2-hydroxyphenyl benzotriazole function which comprises at least one step in which a reaction for hydrosilylation of a compound 2-hydroxyphenyl benzotriazole comprising a substituent having a terminal double bond with a siloxane compound comprising an SiH function is carried out in the presence of a catalyst and of at least one volatile organic solvent corresponding to one of formula (VII) or (VIII). in which Rand R, which may be identical or different, represent a linear or branched C-Calkyl radical, with the proviso that the sum of the carbons of Rand Ris less than or equal to 6; y is and integer between 1 and 3; Rwhich may be identical or different, are linear or branched C-Calkyl radicals, with the proviso that the sum of the carbons of Ris less than or equal to 6 is disclosed. 2. The process according to claim 1 , further comprising:a) charging the compound 2-hydroxyphenyl benzotriazole comprising a substituent comprising a terminal double bond, under an inert nitrogen atmosphere, in the presence of the at least one volatile organic solvent;b) dissolving and charging the catalyst;c) heating a reaction medium comprising the compound 2-hydroxyphenyl benzotriazole comprising a substituent comprising a terminal double bond, the at least one volatile organic solvent, and the catalyst at a temperature below 100° C.;d) adding the siloxane compound comprising a SiH function into the reaction medium so that a reaction mixture comprising the reaction medium and the siloxane compound comprising a SiH function is obtained; ande) purifying the reaction mixture,wherein:the charging a), the dissolving and charging b), the heating c), and the adding d) occur prior to said reacting;said reacting occurs at a temperature below 150° C. until complete conversion is obtained; andthe purifying e) occurs after said reacting.4. The process according to claim 1 , wherein the compound 2-hydroxyphenyl benzotriazole comprising a ...

ORGANOPOLYSILOXANE AND USE THEREOF AS SURFACTANT, POWDER TREATMENT AGENT, THICKENING AGENT OF OIL-BASED RAW MATERIAL OR GELLING AGENT. GEL AND EMULSION COMPOSITIONS, AS WELL AS, PREPARATIONS FOR EXTERNAL USE AND COSMETICS COMPRISING THE SAME

The present invention provides a co-modified organopolysiloxane having a specified chemical structure in which a sugar alcohol-modified group and a silylalkyl group having a siloxane dendron structure, and optionally a long-chain hydrocarbon group are present. The co-modified organopolysiloxane is blended, as a surfactant, a powder treatment agent, a gelling agent or the like, or as a cosmetic raw material together with powder (s), oil agent (s) or the like, in a preparation for external use, and in particular, a cosmetic. 2. The co-modified organopolysiloxane according to claim 1 , wherein in said general formula (1) claim 1 , Rrepresents a substituted or non-substituted claim 1 , and linear or branched monovalent hydrocarbon group having 1 to 8 carbon atoms claim 1 , a polyoxyalkylene group represented by formula: —RO(AO)Rwherein n=1 to 100; AO represents an oxyalkylene group having 2 to 4 carbon atoms; Rrepresents a substituted or non-substituted claim 1 , and linear or branched divalent hydrocarbon group having 3 to 5 carbon atoms; Rrepresents a hydrogen atom claim 1 , a substituted or non-substituted claim 1 , and linear or branched monovalent hydrocarbon group having 1 to 24 carbon atoms claim 1 , or a substituted or non-substituted claim 1 , and linear or branched acyl group having 2 to 24 carbon atoms; an alkoxy group claim 1 , a hydroxyl group or a hydrogen atom claim 1 , with the proviso that all Rs do not represent a hydroxyl group claim 1 , a hydrogen atom claim 1 , said alkoxy group or said polyoxyalkylene group.4. The co-modified organopolysiloxane according to claim 1 , wherein in said general formula (4-1) or (4-2) claim 1 , R is a substituted or non-substituted claim 1 , and linear or branched divalent hydrocarbon group having 3 to 5 carbon atoms.9. A surfactant comprising the co-modified organopolysiloxane according to .10. An emulsion composition comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(A) the co-modified organopolysiloxane ...

Organic electroluminescent element, compounds and materials used for the organic electroluminescent element, and light-emitting, display and illuminating devices using the elements

An organic electroluminescent element is provided that has high luminous efficiency, and a slow luminance deterioration rate in the initial stage of lighting. The organic electroluminescent element includes a substrate; a pair of electrodes including an anode and a cathode, disposed on the substrate; and at least one organic layer including a light emitting layer, disposed between the electrodes, wherein at least one organic layer includes a compound represented by the general formula (1). (R 11 to R 15 represent hydrogen atoms, alkyl groups, or silyl groups, and any one of R 21 to R 24 represents a group represented by general formula (1A) or (1B). Ph 4 represents a p-phenylene group, and at least one of Ph 4a and Ph 4b represents a p-phenylene group.)

Terminal Silicone Capped Regiospecific Glycerin Polyesters

The present invention is directed to a series of glycerin based polymers that have been designed to have very specific substitution patterns, herein referred to as regiospecific substitution (RSS). The attachment of terminal mono-functional silicone polymers engineered polyesters of glycerin results in heretofore unrecognized products. The unique properties include lower surface tension, better spreadability and a dry skin feel, all of which cannot be attained without the use of a terminal silicone. Incorporation of silicone into the terminal position requires a very specific synthesis regime to establish the sought after regiospecificity. 2. A polyester of wherein a is 1.3. A polyester of wherein a is 5.4. A polyester of wherein a is 20.5. A polyester of wherein Ris derived from dimer acid.6. A polyester of wherein Ris an alkyl having 18 carbons.7. A polyester of wherein Ris an alkyl having 7 carbons.9. A polyester of wherein a is 1.10. A polyester of wherein a is 5.11. A polyester of wherein a is 20.12. A polyester of wherein Ris dimer acid.13. A polyester of wherein Ris an alkyl having 18 carbons.14. A polyester of wherein Ris an alkyl having 7 carbons.15. A polyester of wherein Ris an alkyl having 18 carbons.17. A process of wherein said effective conditioning concentration ranges from 0.1% to 45% by weight.18. A process of wherein said effective conditioning concentration ranges from 1% to 20% by weight.20. A process of wherein said effective conditioning concentration ranges from 0.1% to 45% by weight. This application is a continuation in part of co-pending U.S. serial number 13/373,974, filed Dec. 8, 2011.The present invention is directed to a series of glycerin-based polymers that have been designed to have very specific substitution patterns, herein referred to as regio-specific substitution (RSS). The attachment of terminal mono-functional silicone polymers engineered polyesters of glycerin results in heretofore unrecognized products. The unique ...

CHIRAL INTERMEDIATES USEFUL FOR THE PREPARATION OF HYDROXYPHOSPHINE LIGANDS

A compound of formula (I), wherein Ris hydrogen or a hydroxyl protecting group; and Rand Rare same or different and are independently selected from halogen or —O—SO—X; wherein X is —C-Calkyl; C-Calkyl substituted with one or more halogen; or substituted or unsubstituted phenyl wherein said phenyl substituent is selected from halogen, nitro and C-Calkyl; provided that when Ris bromine, X is not p-toluoyl; and a process for the preparation thereof. 3. The compound as claimed in claim 2 , wherein said hydroxyl protecting group is selected from Z or —SO—X.4. The compound as claimed in or claim 2 , wherein Rand Rare same or different and are independently selected from halogen or —O—SO—X provided that when Ris bromine claim 2 , X is not p-toluoyl.5. The compound as claimed in or claim 2 , wherein X is selected from C-Calkyl; C-Calkyl substituted with one or more halogen; and substituted or unsubstituted phenyl wherein said phenyl substituent is selected from halogen claim 2 , nitro and C-Calkyl.7. The compound as claimed in claim 4 , wherein said Rand Rare same or different and are independently selected from F claim 4 , Cl claim 4 , Br claim 4 , I or —O—SO—X.8. The compound as claimed in claim 7 , wherein X is selected from methyl claim 7 , trifluoromethyl claim 7 , n-novafluorobutyl claim 7 , 2 claim 7 ,2 claim 7 ,2-trifluoroethyl claim 7 , p-toluoyl claim 7 , p-nitrophenyl and p-bromophenyl.10. The compound as claimed in or claim 7 , wherein Rand Rare same or different and are independently selected from F claim 7 , Cl claim 7 , Br and I.11. The compound as claimed in or or claim 7 , wherein Z is selected from tetrahydro-2H-pyran-2-yl; tetrahydro-2H-pyran-2-one-3-yl; tetrahydro-2H-pyran-2-methoxy-6-yl and tetrahydro-2H-pyran-2-ethoxy-6-yl.13. Use of a compound as claimed in any preceding claim as an intermediate for the preparation of a hydroxyphosphine ligand.1515. Use of a hydroxyphosphine ligand as a co-catalytic ligand for the enantioselective preparation of a ...

Regiospecific silicone glycerin polyesters

The present invention is directed to a series of silicone containingpolymeric glyceryl esters that have two different molecular weight ester chains, one solid and one liquid, which when combined into a single molecule make a polymer that is solid, but has very unique flow properties. These materials find applications as additives to formulations in personal care products where there is a desire to have a structured film (provided by the solid fatty group) and flow properties, (provided by the liquid fatty group). These compounds by virtue of their unique structure provide outstanding skin feel. 2. A polyester of wherein one of Rand Ris solid and the other liquid.3. A polyester of wherein Ris alkyl having 8 to 12 carbon atoms and Ris alkyl having 16-26 carbon atoms.4. A polyester of wherein Ris an alkyl having 18 carbons.5. A polyester of wherein x is 10.7. A polyester of wherein one of Rand Ris solid and the other liquid.8. A polyester of wherein Ris alkyl having 8 to 12 carbon atoms and Ris alkyl having 16-26 carbon atoms.9. A polyester of wherein Ris an alkyl having 18 carbons.10. A polyester of wherein x is 10.12. A polyester of wherein one of Rand Ris solid and the other liquid.13. A polyester of wherein Ris alkyl having 8 to 12 carbon atoms and Ris alkyl having 16-26 carbon atoms.14. A polyester of wherein Ris an alkyl having 18 carbons.15. A polyester of wherein x is 10. This application is a continuation in part of co-pending U.S. Ser. No. 13/373,974, filed Dec. 8, 2011.The present invention is directed to a series of silicone functionalized glycerin based polymers that have been designed to have very specific substitution patterns, herein referred to as regio-specific substitution (RSS). Natural oils are triglycerides produced by plants and animals as a mechanism to store energy in the form of neutral fats. While being very successful as a store of energy for cells, these products are oily and do not possess the derived aesthetics for widespread use in ...

BRANCHED POLYSILOXANES AND USE OF THESE

Branched polysiloxanes of formula (I) 1. A polysiloxane of formula (I){'br': None, 'sub': a1', 'a2', 'a3', 'b1', 'b2', 'b3', 'c1', 'c2', 'c3', 'd, 'sup': H', 'Vi', 'H', 'Vi', 'H', 'Vi, 'MMMDDDTTTQ\u2003\u2003(I)'}wherein{'sup': 2', '1, 'sub': 2', '1/2, 'M=[RRSiO],'}{'sup': H', '1, 'sub': 2', '1/2, 'M=[RHSiO],'}{'sup': Vi', '3', '1, 'sub': 2', '1/2, 'M=[RRSiO],'}{'sup': '1', 'sub': 2', '2/2, 'D=[RSiO],'}{'sup': H', '1, 'sub': '2/2', 'D=[RHSiO],'}{'sup': Vi', '1', '3, 'sub': '2/2', 'D=[RRSiO],'}{'sup': '4', 'sub': '3/2', 'T=[RSiO],'}{'sup': 'H', 'sub': '3/2', 'T=[HSiO],'}{'sup': Vi', '3, 'sub': '3/2', 'T=[RSiO],'}{'sub': '4/2', 'Q=[SiO],'}{'sup': '1', 'Ris mutually independently identical or different, linear or branched, saturated or unsaturated hydrocarbon moieties,'}{'sup': 2', '1, 'Ris mutually independently the same as R, an alkoxy moiety or a hydroxy group,'}{'sup': '3', 'Ris mutually independently identical or different, linear or branched, olefinically unsaturated hydrocarbon moieties,'}{'sup': 4', '1, 'Ris mutually independently Ror identical or different linear, branched and/or cyclic, saturated or unsaturated hydrocarbon moieties comprising heteroatoms,'}a1=from 0 to 50,a2=from 1 to 50,a3=from 1 to 50,b1=from 10 to 5000,b2=from 0 to 30,b3=from 0 to 30, c1=from 0 to 50,c2=from 0 to 50,c3=from 0 to 50,d=from 0 to 50,with the proviso that the sum c1+c2+c3+d is greater than or equal to 1.2. A polysiloxane according to claim 1 , wherein d is greater than or equal to 1 and c1=c2=c3=0.3. A polysiloxane according to claim 1 , wherein a ratio of the sum of a2 claim 1 , b2 and c2 to the sum of a3 claim 1 , b3 and c3 is from 1:10 to 10:1.4. A polysiloxane according to claim 1 , wherein b2=0 claim 1 , b3=0 and b1>c1+c2+c3+d.5. A process for producing branched polysiloxanes having olefinically unsaturated groups and having SiH groups claim 1 , comprising reactingone or more silanes or siloxanes which have one or more SiH functions and which have no olefinically ...

Cyclopenta[b]Fluorenyl Transition Metal Compound, Catalyst Composition Containing the Same, and Method of Preparing Ethylene Homopolymer or Copolymer of Ethylene and alpha-Olefin Using the Same

The present invention relates to a new transition metal compound based on cyclopenta[b]fluorenyl group, a transition metal catalyst composition containing the same and having high catalytic activity for preparing an ethylene homopolymer or a copolymer of ethylene and one α-olefin, a method of preparing an ethylene homopolymer or a copolymer of ethylene and α-olefin using the same, and the prepared ethylene homopolymer or the copolymer of ethylene and α-olefin.

5-HALOGENOPYRAZOLE(THIO)CARBOXAMIDES

The present invention relates to novel 5-halogenopyrazole(thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. 2. A compound according to claim 1 , wherein T represents an oxygen atom.3. A compound according to claim 1 , wherein R represents hydrogen claim 1 , methylsulfonyl claim 1 , ethylsulfonyl claim 1 , n- or isopropylsulfonyl claim 1 , n- claim 1 , iso- claim 1 , sec- or tert-butylsulfonyl claim 1 , methoxymethyl claim 1 , methoxyethyl claim 1 , ethoxymethyl claim 1 , ethoxyethyl claim 1 , trifluoromethylsulfonyl claim 1 , trifluoromethoxymethyl or formyl.4. A compound according to claim 1 , wherein R represents hydrogen claim 1 , methoxymethyl claim 1 , or formyl.5. A compound according to claim 1 , wherein Rrepresents hydrogen or chlorine.6. A compound according to claim 1 , wherein s or u represents 1.7. A compound according to claim 1 , wherein Rand Rindependently of one another represents hydrogen claim 1 , fluorine claim 1 , chlorine claim 1 , methyl claim 1 , ethyl claim 1 , trifluoromethyl claim 1 , difluoromethyl claim 1 , fluoromethyl claim 1 , trichloromethyl claim 1 , dichloromethyl claim 1 , chloromethyl claim 1 , chlorofluoromethyl claim 1 , fluorodichloromethyl claim 1 , difluorochloromethyl claim 1 , pentafluoroethyl claim 1 , 1-fluoroethyl claim 1 , 2-fluoroethyl claim 1 , 2 claim 1 ,2-difluoroethyl claim 1 , 2 claim 1 ,2 claim 1 ,2-trifluoroethyl claim 1 , 2-chloro-2-fluoroethyl claim 1 , 2-chloro-2 claim 1 ,2-difluoroethyl claim 1 , 2-chloro-2 claim 1 ,2-difluoroethyl claim 1 , 2-dichloro-2-fluoroethyl claim 1 , 2 claim 1 ,2 claim 1 ,2-trichloroethyl claim 1 , 1-chlorobutyl claim 1 , heptafluoro-n-propyl or heptafluoroisopropyl.8. A compound according to claim 1 , wherein Rrepresents represents hydrogen claim 1 , fluorine claim 1 , chlorine claim ...

Process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds; use of the said compounds obtained via the process in the synthesis of siloxane compounds containing a 2-hydroxyphenylbenzotriazole function

The process for preparing 2-hydroxyphenyl alkenyl benzotriazole compounds and the process for preparing siloxane compounds containing 2-hydroxyphenyl benzotriazole function are disclosed.

Inhibitors of Human Immunodeficiency Virus Replication

The disclosure generally relates to compounds of formula I, including compositions and methods for treating human immunodeficiency virus (HIV) infection. The disclosure provides novel inhibitors of HIV, pharmaceutical compositions containing such compounds, and methods for using these compounds in the treatment of HIV infection. 2. A compound of where:{'sup': 1', '6', '7, 'Ris N(R)(R);'}{'sup': '2', 'Ris hydrogen;'}{'sup': 3', '1, 'Ris Ar;'}{'sup': '4', 'Ris alkyl;'}{'sup': '5', 'Ris alkyl;'}{'sup': 6', '2', '2', '2', '2', '2', '2, 'Ris hydrogen, alkyl, haloalkyl, (cycloalkyl)alkyl, (Ar)alkyl, cycloalkyl, (alkyl)CO, ((cycloalkyl)alkyl)CO, (Ar)CO, ((Ar)alkyl)CO, ((Ar)alkyl)OCO, ((Ar)alkyl)NHCO, or ((Ar)alkyl)COCO;'}{'sup': '6', 'or Ris ((trialkylsilyl)alkyl)OCO, (benzyloxy)alkylCO, (phenoxyalkyl)CO, (isoindolinedionyl)alkyl)CO, (((dialkyl)cycloalkoxy)alkyl)CO, (phenoxyalkyl)CO, or (dihalobenzodioxolyl)CO;'}{'sup': '7', 'Ris hydrogen or alkyl;'}{'sup': 6', '7, 'or where N(R)(R) taken together is pyrrolidinyl or piperidinyl, and is substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxy, alkoxy, and haloalkoxy;'}{'sup': '1', 'Aris chromanyl substituted with 0-3 substituents selected from halo, cyano, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, hydroxy, alkoxy, haloalkoxy, phenoxy, benzyloxy, thioalkyl, and acetamido; and'}{'sup': '2', 'Aris phenyl, pyrazolyl, indolyl, or fluorenonyl, and is substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy, benzyloxy, and haloalkoxy;'}or a pharmaceutically acceptable salt thereof.3. A compound of where Ris hydrogen.4. A compound of where Ris Ar.5. A compound of where Ris alkyl.6. A compound of where Ris hydrogen claim 1 , alkyl claim 1 , haloalkyl claim 1 , (cycloalkyl)alkyl claim 1 , (Ar)alkyl claim 1 , cycloalkyl claim 1 , (alkyl)CO claim 1 , ((cycloalkyl)alkyl)CO claim 1 , (Ar)CO claim 1 , ((Ar)alkyl)CO claim 1 , ((Ar)alkyl)OCO claim 1 , ((Ar) ...

N-ARYL PYRAZOLE(THIO)CARBOXAMIDES

The present invention relates to novel (thio)carboxamides, their process of preparation, their use as fungicide active agents, particularly in the form of fungicide compositions, and methods for the control of phytopathogenic fungi, notably of plants, using these compounds or compositions. 2. A compound according to claim 1 , wherein Xand Xindependently from each other represents fluorine or chlorine.3. A compound according to claim 1 , wherein Rrepresents a substituted or non-substituted C-C-alkyl claim 1 , a C-C-halogenoalkyl having 1 to 5 halogen atoms or a non-substituted C-C-cycloalkyl.4. A compound according to claim 3 , wherein Rrepresents methyl or cyclopropyl.6. A compound according to claim 5 , wherein M represents M-1 or M-3.7. A compound according to wherein n is 0 or 1 and Rrepresents fluorine.8. A compound according to wherein Q represents a direct bond or O (oxygen).9. A compound according to claim 1 , wherein Rrepresents hydrogen claim 1 , C-C-alkyl claim 1 , C-C-alkoxy-C-C-alkyl claim 1 , C-C-alkylsulfanyl-C-C-alkyl or C-C-cycloalkyl.10. A compound according to claim 1 , wherein Wrepresents fluorine claim 1 , chlorine claim 1 , bromine claim 1 , methyl claim 1 , ethyl claim 1 , n- or i-propyl claim 1 , n- claim 1 , i- claim 1 , s- or t-butyl claim 1 , methoxy claim 1 , ethoxy claim 1 , n- or i-propoxy claim 1 , trifluoromethyl claim 1 , trifluoroethyl claim 1 , difluoro-methoxy claim 1 , trifluoromethoxy claim 1 , difluorochloromethoxy claim 1 , trifluoroethoxy claim 1 , in each case doubly attached difluoromethylenedioxy or tetrafluoroethylenedioxy claim 1 , or the groupings —CHSi(CH) claim 1 , —Si(CH)or —C(Q)=N-Q claim 1 , in which{'sup': '2', 'Qrepresents hydrogen, methyl, ethyl or trifluoromethyl and'}{'sup': '3', 'Qrepresents hydroxyl, methoxy, ethoxy, propoxy or isopropoxy.'}11. A compound according to claim 1 , wherein Zrepresents 2-pyridinyl claim 1 , 3-pyridinyl or 4-pyridinyl claim 1 , each of which is optionally mono- to trisubstituted by ...

HIGLY DISPERSIBLE SILICA FOR USING IN RUBBER

The present invention relates to highly disperse precipitated silicas which exhibit an extremely high level of reinforcement of rubber vulcanizates, to a process for their preparation, and to their use as filler for rubber mixtures. 1: A process for preparing a precipitated silica comprisinga) taking an aqueous solution of an alkali metal silicate or alkaline earth metal silicate and/or of an organic and/or inorganic base with an alkali value from 7 to 30 as initial charge,b) metering water glass and an acidifier simultaneously into this initial charge at from 55 to 95° C., with stirring, for from 10 to 120 minutes, in such a way that during the precipitation the AV remains constant at from 7 to 30,c) using an acidifier to acidify to pH of from approximately 2.5 to 6, andd) filtering, washing and drying.2: The process as claimed in claim 1 , wherein the AV in b) is from 15 to 30.3: The process as claimed in claim 1 , wherein the AV in b) is from 18 to 30.4: The process as claimed in claim 1 , wherein after a) claim 1 , b) is carried out in a manner which comprisesb′) stopping the feed for from 30 to 90 minutes while maintaining the temperature, andb″) then, at the same temperature, for from 10 to 120 minutes, simultaneously adding water glass and an acidifier in such a way that the AV remains constant during the precipitation.5: The process as claimed in claim 4 , wherein b″) is carried out for from 10 to 60 minutes.6: The process as claimed in claim 1 , wherein during b) claim 1 , an organic or inorganic salt is added.7: The process as claimed in claim 4 , wherein during b′) and/or b″) claim 4 , an organic or inorganic salt is added.8: The process as claimed in claim 1 , wherein drying is carried out in a pneumatic drier claim 1 , spray drier claim 1 , disk drier claim 1 , belt drier claim 1 , rotating-tube drier claim 1 , flash drier claim 1 , spin flash drier claim 1 , or spray tower.9: The process as claimed in claim 8 , wherein after drying claim 8 , ...

SUBSTITUTED PHENOXYPYRIDINES

The present invention relates to substituted phenoxypyridine compounds of general formula (I) in which R1, R2 and R3 are as defined in the claims, to methods of preparing said compounds, to intermediates for the preparation of said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyper-proliferative and/or angiogenesis disorder, as a sole agent or in combination with other active ingredients. 2. The compound according to claim 1 , wherein:{'sub': 1', '6', '2', '6', '3', '6, 'claim-text': a halogen atom, or a', {'sub': 1', '6', '1', '6', '2', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '1', '6', '3', '10', '1', '6', '1', '6', '1', '6', '1', '6', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '2', '1', '6', '2', '1', '6', '2', '2', '2', '2', '2', '2, 'CN, C-C-alkyl-, halo-C-C-alkyl-, HN—C-C-alkyl-, R(R′)N—C-C-alkyl-, HO—C-C-alkyl, C-C-alkyl substituted with two OH groups, C-C-alkoxy-C-C-alkyl-, halo-C-C-alkoxy-C-C-alkyl-, C-C-cycloalkyl-C-C-alkyl-, 3- to 10-membered 3- to 7-membered heterocycloalkyl-C-C-alkyl-, aryl-C-C-alkyl-, heteroaryl-C-C-alkyl-, —C(═O)R, —C(═O)NH, —C(═O)N(H)R, —C(═O)N(R)R′, —C(═O)OH, —C(═O)OR, —NH, —N(H)R, —N(R)R′, —N(H)C(═O)H, —N(H)C(═O)R, —N(R)C(═O)R′, —N(H)C(═O)NH, —N(H)C(═O)N(H)R, —N(H)C(═O)N(R)R′, —N(R)C(═O)NH, —N(R)C(═O)N(H)R, —N(R)C(═O)N(R)R′, —N(H)C(═O)OR, —N(R)C(═O)OR, —NO, —N(H)S(═O)R, —N(R)S(═O)R′, —N(H)S(═O)NH, —N(H)S(═O)N(H)R, —N(H)S(═O)N(R)R′, —N(R)S(═O)NH, —N(R)S(═O)N(H)R′, —N(R)S(═O)N(R′)R″, —N(H)S(═O)R, —N(H)S(═O)—C3-C6-cycloalkyl, —N(R)S(═O)R′, —N(H)S(═O)NH, —N(H)S(═O)N(H)R, —N(H)S(═O)N(R)R′, —N(R)S(═O)NH, —N(R)S(═O)N(H)R, —N(R)S(═O)N(R′)R″, —N═S(═O)(R)R′, —OH, C-C-alkoxy-, —OC(═O)H, —OC(═O)R, —OC(═O)NH, —OC(═O)N(H)R, —OC(═O)N(R)R′, —OC(═O)OR, —SH, C-C-alkyl-S—, —SC(═O)NH, —SC(═O)N(H)R, ...

Monocyclic cyanoenones and methods of use thereof

The present invention features monocyclic cyanoenone compositions and methods for using the same in the treatment of diseases such as cancer, inflammatory diseases and neurodegenerative diseases.

LOW MOLECULAR WEIGHT CARBOSILANES, PRECURSORS THEREOF, AND METHODS OF PREPARATION

A series of silicon compounds are provided, which are excellent precursors to small carbosilanes, such as 1,3,5-trisilapentane, 2,4,6-trisilaheptane, tris(silylmethyl)silane and tetrakis(silylmethyl)silane. A method of preparing a carbosilane involves forming a Grignard, lithium, or metallic reagent from a halomethyltrialkoxysilane, reacting the Grignard, lithium, or metallic reagent with a dihalodihydridosilane, a trihalohydridosilane, a tetrahalosilane, a dialkoxydihydridosilane, a trialkoxyhydridosilane, or a tetraalkoxysilane to yield a carbosilane precursor, and reducing the precursor to form the carbosilane.

BRANCHED SILOXANES AND METHODS FOR SYNTHESIS

The present invention describes branched and functionalized siloxanes and methods for making such compounds. The compounds have a variety of uses. One preferred application is as novel planarizing material for lithography, in which case functionalized branched siloxane, such as an epoxy-modified branched siloxane is particularly useful. 2. The method of claim 1 , wherein said siloxane comprising a silicon-hydrogen bond represented by the formula (a) is 3H claim 1 ,5H-octamethyltetrasiloxane.3. The method of claim 1 , wherein m is either 2 or 3.4. The method of claim 2 , wherein said 3H claim 2 ,5H-octamethyltetrasiloxane claim 2 , prior to reacting with said asymmetric linear siloxane claim 2 , is exposed to a catalyst in the presence of water.5. The method of claim 4 , wherein said catalyst is removed prior to reacting said 3H claim 4 ,5H-octamethyltetrasiloxane with said asymmetric linear siloxane.6. The method of claim 4 , wherein said catalyst is a palladium catalyst.7. The method of claim 1 , wherein the halogen of said asymmetric linear siloxane is chlorine.8. The method of claim 1 , further comprising the step of purifying the branched siloxane by distillation claim 1 , so as to remove said byproducts of the synthesis reaction and provide a purified branched siloxane.9. The method of claim 8 , further comprising the step of functionalizing said purified branched siloxane.10. The method of claim 9 , wherein said functionalizing comprises attaching photo-crosslinkable moieties claim 9 , said moieties selected from the group consisting of acrylates claim 9 , methacrylates claim 9 , vinyls and epoxides.11. The method of claim 9 , wherein said functionalizing comprises hydrosylilation.12. The branched siloxane Si-12 having the structure shown in .13. The functionalized branched siloxane Si-12 having the structure shown in claim 9 , wherein X is a chemical moiety.14. The functionalized branched siloxane Epoxy-Si-12 having the structure shown in . The present ...

FLUORESCENT PROBE

A compound represented by the formula (I) (Rrepresents hydrogen atom or a monovalent substituent; Rand Rrepresent hydrogen atom, an alkyl group, or a halogen atom; Rand Rrepresent an alkyl group or an aryl group; Rand Rrepresent hydrogen atom, an alkyl group, or a halogen atom; Rrepresent hydroxy group or a dialkoxyboranetriyl group; and X represents silicon atom, germanium atom, or tin atom), which is a novel fluorophore usable as a mother nucleus of an off/on type fluorescent probe not utilizing the intramolecular photoinduced electron transfer. 2. The compound or a salt thereof according to claim 1 , wherein X is silicon atom claim 1 , or germanium atom claim 1 , and Rand Rare both hydrogen atoms claim 1 , both chlorine atoms claim 1 , or both fluorine atoms.3. The compound or a salt thereof according to claim 1 , wherein Ris hydrogen atom claim 1 , or 1 to 3 monovalent substituents existing on the benzene ring (the substituents are selected from the group consisting of an alkyl group having 1 to 6 carbon atoms claim 1 , an alkenyl group having 1 to 6 carbon atoms claim 1 , an alkynyl group having 1 to 6 carbon atoms claim 1 , an alkoxy group having 1 to 6 carbon atoms claim 1 , hydroxy group claim 1 , carboxy group claim 1 , sulfonyl group claim 1 , an alkoxycarbonyl group claim 1 , a halogen atom claim 1 , and amino group) claim 1 , Rand Rare independently hydrogen atom claim 1 , an alkyl group having 1 to 6 carbon atoms claim 1 , or a halogen atom claim 1 , Rand Rare independently an alkyl group having 1 to 6 carbon atoms claim 1 , and Ris hydroxy group.4. The compound or a salt thereof according to claim 1 , which is for use in manufacture of a fluorescent probe.6. The compound or a salt thereof according to claim 5 , wherein X is silicon atom claim 5 , or germanium atom claim 5 , and Rand Rare both hydrogen atoms claim 5 , both chlorine atoms claim 5 , or both fluorine atoms.7. The compound or a salt thereof according to claim 5 , wherein Ris hydrogen atom ...

Method Of Forming An MT-Propyl Siloxane Resin

A method of forming an MT-propyl siloxane resin includes the steps of hydrolyzing propyl trichlorosilane in an excess of water to provide a T-propyl siloxane resin and capping the T-propyl siloxane resin formed from the hydrolysis of the propyl trichlorosilane with a silicon-containing M-group capping agent to form the MT-propyl siloxane resin. The MT-propyl siloxane resin is useful in a variety of personal care applications, and in particular, as an additive to personal care compositions. 2. The method of forming an MT-propyl siloxane resin of claim 1 , wherein the step of hydrolyzing propyl trichlorosilane is conducted in the presence of an organic solvent claim 1 , and the method further comprises the step of conducting a solvent-exchange between the organic solvent and an alternative carrier solvent.3. The method of forming an MT-propyl siloxane resin of claim 1 , wherein the MT-propyl siloxane resin comprises from 0.05 to 0.40 moles of silanol groups per mole of silicon.4. The method of forming an MT-propyl siloxane resin of claim 1 , wherein the MT-propyl siloxane resin has the average formula:{'br': None, 'sup': 2', '1, 'sub': 3', '1/2', 'a', '3/2', 'c, '(RSiO)(RSiO), whereina is less than 0.20, and ‘c’ ranges from 0.80 to less than 1, with the proviso that a+c=1.6. The method of forming an MT-propyl siloxane resin of claim 1 , wherein the silicon-containing M-group capping agent comprises trimethylchlorosilane or a hydrolyzate thereof.7. The method of forming an MT-propyl siloxane resin of claim 1 , wherein the silicon-containing M-group capping agent is provided before the step of hydrolyzing propyl trichlorosilane.10. (canceled)11. An MT-propyl siloxane resin claim 1 , wherein the MT-propyl siloxane resin has the average formula:{'br': None, 'sup': 2', '1, 'sub': 3', '1/2', 'a', '3/2', 'c, '(RSiO)(RSiO), whereina is less than 0.20, and c ranges from 0.80 to less than 1, with the proviso that a+c=1.12. The MT-propyl siloxane resin of claim 11 , wherein the ...

Asymmetric Hosts With Triaryl Silane Side Chains

Novel asymmetric host compounds containing an electron-transport moiety, a hole-transport moiety, an aromatic spacer, and a triaryl silane group are provided. These compounds are useful materials that can be incorporated into OLED devices.

PREPARATION PROCESS OF AN ANTIVIRAL DRUG (ENTECAVIR) AND INTERMEDIATES THEREOF

It comprises a preparation process of entecavir comprising: submitting a (1S,3R)-3-(tert-butyldimethylsilyloxy)-1-(oxiran-2-yl)pent-4-yn-1-ol (VIII) to a double esterification and to a radicalary cyclization, yielding a compound of formula (V), where either a compound of formula (VIII) is submitted to a first esterification reaction, then to a catalytic radicalary cyclization using titanocene dichloride as catalyst in the presence of Mn/2,4,6-collidine HCl or Zn/2,4,6-collidine/trimethylsilyl chloride, and finally to a second esterification reaction or, alternatively, the compound of formula (VIII) is submitted first to a catalytic radicalary cyclization, and then to an esterification reaction. Entecavir can be obtained by submitting compound (V) to a desilylation reaction to remove the TBS group and then to a Mitsunobu coupling with 2-amino-6-chloroguanine, followed by hydrolysis. It also relates to some new intermediates of the process. 2. The process according to claim 1 , wherein the esterification reaction is an acetylation reaction.3. The process according to claim 1 , wherein the compound of formula (VIII) is transformed into the compound of formula (V) by the sequence of reactions comprising a first esterification claim 1 , a catalytic radicalary cyclization claim 1 , and a second esterification.4. The process according to claim 1 , wherein the amount of titanocene chloride is comprised between 15-25% w/w in respect of compound of formula (VII) or of compound of formula (VIII).5. The process according to claim 4 , wherein the solvent of the radical cyclization is tetrahydrofuran or 2-methyl tetrahydrofuran.11. (canceled)13. (canceled)14. (canceled)15. (canceled)16. (canceled)17. The process according to claim 2 , wherein the compound of formula (VIII) is transformed into the compound of formula (V) by the sequence of reactions comprising a first esterification claim 2 , a catalytic radicalary cyclization claim 2 , and a second esterification. The present ...

Organic compound, organic electroluminescence element, and image display device

The present invention provides an organic electroluminescence element having a high luminous efficiency. An organic electroluminescence element includes an anode, a cathode, and at least one organic compound layer disposed between the anode and the cathode, wherein at least one of the at least one the organic compound layer contains an organic compound shown in Claim 1.

INTERMEDIATES FOR THE SYNTHESIS OF BENZINDENE PROSTAGLANDINS AND PREPARATIONS THEREOF

Novel processes for preparing optically active cyclopentanones 1 2. A process according to claim 1 , wherein M is phenyl or 4-phenylphenyl. This application is a divisional of U.S. patent application Ser. No. 13/216,378 filed Aug. 24, 2011.1. Field of the InventionThe present invention relates to novel processes for preparing cyclopentanones of Formula 1,which are useful for the preparation of benzindene Prostaglandins. The invention also relates to novel cyclopentanones prepared from the processes.2. Description of the Prior ArtFlolan (Epoprostenol) is the first drug approved by Food and Drug Administration for the treatment of pulmonary hypertension. However, Epoprostenol is extremely unstable and normally has a half-life of about 3˜5 minutes and needs to be administered via continuous intravenous administration and be stored at lower temperatures. Benzindene Prostaglandins, such as UT15 (Treprostinil), are derivatives of Epoprostenol and are a new class of drugs for the treatment of pulmonary hypertension. Benzindene prostaglandins are more stable and thus more convenient and safer in utilization as compared to Epoprostenol.As shown in Scheme 1, cyclopentanones of Formula 1a are important intermediates for the synthesis of benzindene prostaglandins, such as UT15 (Tetrahedron Letters (1982), 23(20), 2067-70):However, as shown in Scheme 2, the synthesis of cyclopentanones of Formula 1a should be started with the intermediate B and undergoes eight steps (43, No. 11, 1978), and would involve more than 20 chemical steps, including the steps for the synthesis of the intermediate B. Such synthesis is very complicated and only achieves a low yield.Consequently, there is a demand in the industry for processes for the preparation of cyclopentanones of Formula 1 and benzindene prostaglandins that involve less steps and are more convenient to operate.The present invention provides novel processes of preparing optically active cyclopentanones 1 and novel cyclopentanones.The ...

ORGANIC-INORGANIC METAL OXIDE HYBRID RESIN, A METHOD FOR FORMING THE SAME, AND TRANSPARENT RESIN COMPOSITION FORMED THEREFROM

In one embodiment, an organic-inorganic metal oxide hybrid resin having the following formula: 2. The organic-inorganic metal oxide hybrid resin as claimed in claim 1 , wherein each Ris independently a Cto Calkyl group claim 1 , and each Ris independently a Cto Calkyl group or a benzyl group.3. The organic-inorganic metal oxide hybrid resin as claimed in claim 1 , wherein M is Titanium (Ti) claim 1 , Zirconium (Zr) claim 1 , or Zinc (Zn).5. The organic-inorganic metal oxide hybrid resin as claimed in claim 1 , wherein a weight-average molecular weight of the organic-inorganic metal oxide hybrid resin is between 8000 and 30000.6. The organic-inorganic metal oxide hybrid resin as claimed in claim 1 , wherein the organic-inorganic metal oxide hybrid resin is a transparent glutinous liquid having a refractive index of between 1.6 and 1.95.8. A transparent resin composite claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '10 to 80 parts by weight of the organic-inorganic metal oxide hybrid resin as claimed in ; and'}20 to 90 parts by weight of liquid epoxy resin.9. The transparent resin composite as claimed in claim 8 , wherein the liquid epoxy resin comprises bisphenol A type epoxy claim 8 , cycloaliphatic epoxy claim 8 , cycloaliphatic modified siloxane claim 8 , or combinations thereof.10. The transparent resin composite as claimed in claim 8 , wherein a weight-average molecular weight of the liquid epoxy resin is between 200 and 20000.11. The transparent resin composite as claimed in claim 8 , wherein a viscosity of the liquid epoxy resin is between 100 cps and 30000 cps.12. The transparent resin composite as claimed in claim 8 , further comprising:0.01 to 1 parts by weight of an additive, wherein the additive comprises a cocatalyst, a fluorescent whitening agent, an antioxidant, or combinations thereof.13. The transparent resin composite as claimed in claim 12 , wherein the cocatalyst comprises a cocatalyst containing aluminum complex.14. The ...

Method of Selectively Forming a Reaction Product in the Presence of a Metal Silicide

A reaction product is formed utilizing a method that includes the step of combining a metal silicide and an aliphatic hydrocarbyl halide at a temperature of from 200° C. to 600° C. The aliphatic hydrocarbyl halide has the formula HCX, wherein a is 0 or more, b is 1 or more, c is one or more, and X is halo. The method allows the reaction product to be formed in a predictable and controlled manner. Moreover, the components used in this method can be easily recycled and/or re-used in other processes. 1. A method of forming a reaction product , said method comprising a step of combining a metal silicide and an aliphatic hydrocarbyl halide in a reactor at a temperature of from 200° C. to 600° C. to form the reaction product wherein the metal silicide comprises a Group I or Group II metal.2. A method as set forth in wherein the metal silicide is further defined as MgSi.3. A method as set forth in wherein the aliphatic hydrocarbyl halide is further defined as an alkyl halide of formula RX claim 1 , wherein R is C-Calkyl and wherein X is halo.4. A method as set forth in wherein X is chloro.5. A method as set forth in or wherein R is further defined as methyl.6. A method as set forth in wherein the reaction product comprises at least one polysilane having the formula RSi(RSi)SiRwherein each R is independently C-Calkyl claim 1 , halo claim 1 , or —H claim 1 , and m has an average value of from 1 to 5.7. A method as set forth in wherein the at least one polysilane is linear.8. A method as set forth in wherein the reaction product comprises at least two polysilanes and at least one of the polysilanes is branched.9. A method as set forth in wherein the reaction product comprises at least two polysilanes and at least one of the polysilanes is cyclic.10. A method as set forth in wherein the reaction product comprises at least one polycarbosilane having the formula RSi—CH(RSi—CH)SiRwherein each Ris independently C-Calkyl claim 1 , halo claim 1 , or —H claim 1 , and n has an average ...

Polymers, Their Preparation and Uses

A polymer containing an optionally substituted repeat unit of formula (I) wherein each R is the same or different and represents H or an electron withdrawing group, and each R 1 is the same or different and represents a substituent.

Chemosensory Receptor Ligand-Based Therapies

Provided herein are methods for treating conditions associated with a chemosensory receptor, including diabetes, obesity, and other metabolic diseases, disorders or conditions by administering a composition comprising a chemosensory receptor ligand. Also provided herein are chemosensory receptor ligand compositions and methods for the preparation thereof for use in the methods of the present invention. 193-. (canceled)120. A composition according to claim 94 , wherein the composition further releases at least some of the chemosensory receptor ligand in the stomach.121. A composition according to claim 94 , wherein one or more regions of the intestine are the duodenum claim 94 , jejunum claim 94 , ileum claim 94 , caecum claim 94 , colon and/or rectum.122. A composition according to claim 94 , wherein the composition releases at an onset of about 5 to about 45 minutes claim 94 , about 105 to about 135 minutes claim 94 , about 165 to about 195 minutes claim 94 , about 225 to about 255 minutes or a combination of times thereof following administration to a subject.123. A composition according to claim 94 , wherein the composition releases at an onset of about pH 5.0 claim 94 , about pH 5.5 claim 94 , about pH 6.0 claim 94 , about pH 6.5 claim 94 , about pH 7.0 claim 94 , or combination thereof following administration to a subject.124. A composition according to claim 94 , the composition further comprising a second chemosensory receptor ligand selected from the group consisting of a sweet receptor ligand claim 94 , a bitter receptor ligand claim 94 , an umami receptor ligand claim 94 , a fat receptor ligand claim 94 , a sour receptor ligand and a bile acid receptor ligand.125. A composition according to claim 124 , wherein the sweet receptor ligand is selected from the group consisting of sucralose claim 124 , aspartame claim 124 , Stevioside claim 124 , Rebaudioside A claim 124 , Rebaudioside B claim 124 , Rebaudioside C claim 124 , Rebaudioside D claim 124 , ...

Iminipyridine derivatives and their uses as microbiocides

Compounds of the formula I in which the substituents are as defined in claim 1 are suitable for use as microbiocides.

SILANE COMPOUND, PRODUCTION METHOD THEREOF, AND RESIN COMPOSITION CONTAINING SILANE COMPOUND

A siloxane compound comprising a structure unit formed by connecting at least one organic skeleton having an imido bond to a silicon atom forming a siloxane bond, wherein the silane compound is defined by the following average formula: XaYbZcSiOd. X denotes groups including an organic skeleton having an imido bond, represented by formula (1) in the specification; Z denotes an organic groups having no imido bond; Y denotes at least one of hydrogen, hydroxyl, halogen, and OR; R denotes at least one of alkyl, acyl, aryl, and unsaturated aliphatic residual groups and may have a substituent; a is ≦3 and >0; b is 0≦3; c is 0≦3; d is ≦2 and >0; and a+b+c+2d=4, Rdenotes at least one from aromatic, heterocyclic, and alicyclic rings; x and z independently ≧0 and ≦5; and y is 0 or 1. 2. The siloxane compound according to claim 1 , wherein claim 1 , in the average composition formula claim 1 , the coefficient a for X satisfies 0.5 or more.3. The siloxane compound according to claim 1 ,wherein the number of bonds between a silicon atom to which X is connected and an oxygen atom is 3.4. The siloxane compound according to claim 1 , wherein the number of bonds between a silicon atom forming the siloxane bond and an oxygen atom is 3.5. The siloxane compound according to any claims 1 , wherein a ratio of a silanol group amount claims 1 , calculated by the following formula (α) claims 1 , is 0.1 or less{'br': None, '[molar number of Si—OH bond]/[molar number of Si—O bond]\u2003\u2003(α).'}6. The siloxane compound according to claim 1 , wherein the siloxane compound has a cage-like molecular structure.7. A silane compound according to claim 1 , wherein X+Y is 3 claim 1 , and y is 0. This application is a Divisional application co-pending application Ser. No. 12/526,002, filed on Nov. 2, 2009 (allowed), which is a national phase of PCT/JP2008/0052480, filed on Feb. 7, 2008, which claims priority to JP 2007-031177 filed Feb. 9, 2007, JP 2007-129633, filed May 15, 2007, JP 2007-149576 ...

SILICONE RESIN COMPOSITION

A first silicone resin composition is prepared by allowing an organopolysiloxane containing silanol groups at both ends containing silanol groups at both ends of a molecule and a silicon compound containing, in one molecule, at least two leaving groups leaving by a condensation reaction with the silanol groups to undergo the condensation reaction in the presence of a condensation catalyst. The silicon compound contains a trifunctional silicon compound containing, in one molecule, the three leaving groups and a bifunctional silicon compound containing, in one molecule, the two leaving groups. 1. A first silicone resin composition prepared by allowing an organopolysiloxane containing silanol groups at both ends containing silanol groups at both ends of a molecule and a silicon compound containing , in one molecule , at least two leaving groups leaving by a condensation reaction with the silanol groups to undergo the condensation reaction in the presence of a condensation catalyst , whereinthe silicon compound comprises:a trifunctional silicon compound containing, in one molecule, the three leaving groups anda bifunctional silicon compound containing, in one molecule, the two leaving groups.2. The first silicone resin composition according to claim 1 , whereinthe molar ratio of the leaving group in the trifunctional silicon compound to the leaving group in the bifunctional silicon compound is 30/70 to 90/10.3. The first silicone resin composition according to claim 1 , whereinthe condensation catalyst is a tin-based catalyst.4. The first silicone resin composition according to claim 1 , whereinthe trifunctional silicon compound and/or the bifunctional silicon compound further contain(s), in one molecule, at least one monovalent ethylenically unsaturated hydrocarbon group.5. A second silicone resin composition prepared by allowing an organopolysiloxane containing silanol groups at both ends containing silanol groups at both ends of a molecule and a silicon compound ...

Aromatic heterocyclic derivative, material for organic eletroluminescent element, and organic electroluminescent element

An organic EL device includes an anode, an emitting layer, an electron transporting zone and a cathode in this sequence, in which the electron transporting zone contains an aromatic heterocyclic derivative represented by a formula (1) below. In the formula (1), X 1 to X 3 are a nitrogen atom or CR 1 , and A is represented by a formula (2) below. In the formula (2), L 1 is s single bond or a linking group, and HAr is represented by a formula (3) below. In the formula (3), Y 1 is an oxygen atom, a sulfur atom or the like, and one of X 11 to X 18 is a carbon atom bonded to L 1 by a single bond and the rest of X 11 to X 18 are a nitrogen atom or CR 13 .

Molecular glasses with functionalizable groups

Disclosed herein is a compound having Formula I: or a salt thereof, in which R 1 , R 2 and R 3 are as defined herein. Also disclosed are processes to prepare compounds of Formula I and use of compounds of Formula I to prepare stable glassy phases.

NEW (TRIORGANOSILYL)ALKYNES AND THEIR DERIVATIVES AND A NEW CATALYTIC METHOD FOR OBTAINING NEW AND CONVENTIONAL SUBSTITUTED (TRIORGANOSILYL)ALKYNES AND THEIR DERIVATIVES

The present invention relates to new (triorganosilyl)alkynes and their derivatives having general formula 1 R—C≡C—Z (I) In its second aspect, this invention relates to a new selective method for the preparation of new and conventional (triorganosilyl)alkynes and their derivatives having the general formula 1, by the silylative coupling of terminal alkynes with halogenotriorganosilanes in the presence of an iridium catalyst and a tertiary amine. 3. A method as claimed in wherein the iridium complex used is [{Ir(μ-Cl)(CO)}].4. A method as claimed in wherein the iridium complex is used in an amount in the range from 0.01 to 4 mol % relative to the functional terminal alkyne group.5. A method as claimed in wherein the iridium complex is used in an amount in the range from 1 to 2 mol % relative to the functional terminal alkyne group.6. A method as claimed in claim 2 , wherein the amine having the formula 5 is used in an amount not smaller than that equivalent to the sum of a stoichiometric amount of the hydrogen halide formed and a 2.2-fold excess relative to the iridium ion in the complex used.8. A method as claimed in wherein the iridium complex used is [{Ir(μ-Cl)(CO)2}2].9. A method as claimed in wherein the iridium complex is used in an amount in the range from 0.01 to 4 mol % relative to the functional terminal alkyne group.10. A method as claimed in wherein the iridium complex is used in an amount in the range from 0.5 to 1 mol % relative to the functional terminal alkyne group.11. A method as claimed in wherein claim 9 , in the synthesis of the compounds containing an amine substitute claim 9 , the iridium complex is used in an amount in the range from 0.5 to 2 mol % relative to the functional terminal alkyne group.12. A method as claimed in claim 7 , wherein the amine having the formula 5 is used in an amount not smaller than that equivalent to the sum of a stoichiometric amount of the hydrogen halide formed and a 2.2-fold excess relative to the iridium ion in ...

ORGANOPOLYSILOXANE AND MAKING METHOD

Organopolysiloxanes containing a sulfide-containing organic group, a long-chain alkyl group, and a hydrolyzable group are novel. The organopolysiloxanes are effective for improving the shelf stability of epoxy resin compositions. 3. The organopolysiloxane of wherein in the average compositional formula (1) claim 1 , d is 0 Подробнее

Tertiary s-nitrosothiol-modified nitricoxide-releasing xerogels and methods of using the same

Provided according to embodiments of the invention are novel tertiary alkyl thiol compounds and novel tertiary alkyl nitrosothiol compounds. Further provided according to embodiments of the invention are methods of forming a nitric oxide (NO)-releasing xerogel coating that include (a) co-condensing a sol precursor solution comprising at least one backbone alkoxysilane and at least one tertiary thiol alkoxysilane in a solvent to form a sol; (b) coating a substrate with the sol; (c) optionally, drying the sol to form the xerogel coating; and (d) contacting the xerogel coating with a nitrosating agent. Methods of using xerogel coatings are also included.

Apparatus for generating 1-methylcyclopropene

Provided is an apparatus for generating 1-methylcyclopropene. The apparatus of the present invention may enable the immediate and convenient generation of 1-methylcyclopropene in a desired location using stable 1-methylcyclopropene precursors.

HOLLOW SPHERE WITH MESOPOROUS STRUCTURE AND METHOD FOR MANUFACTURING THE SAME

The present invention relates to a hollow sphere with a mesoporous structure, and a method for manufacturing the same. The hollow sphere with a mesoporous structure comprises: a shell with plural mesopores penetrating the shell, wherein the shell comprises: a mesoporous silicon oxide material, and mesopores of the mesoporous silicon oxide material are arranged in Ia3d cubic symmetry. In addition, according to the method of the present invention, the aforementioned hollow sphere with the mesoporous structure can be easily obtained by use of mixed surfactants of a cationic surfactant and a non-ionic surfactant. 1. A hollow sphere with a mesoporous structure , comprising:{'sub': 1', '4', '1', '4', '2', '1-3', '2', '1-3', '2', '1-3', '2', '1-3', '2', '1-3', '2', '2', '1-3, 'a shell with plural mesopores penetrating both surfaces of the shell, wherein the shell is made of a silicon dioxide material with orderly-arranged mesopores and further comprises surface-bound functional groups, which are selected from the group consisting of a C-Calkyl group, a C-Calkoxy group, —(CH)—SH, —(CH)—CN, —(CH)—OCN, —(CH)—X, —(CH)—NH, and —(CH)—COOH, and X is Cl, Br, or I ; and the mesopores of the silicon dioxide material are arranged in Ia3d cubic symmetry.'}2. The hollow sphere with the mesoporous structure as claimed in claim 1 , wherein the surface-bound functional groups are —(CH)—SH claim 1 , or —(CH)—CN.3. The hollow sphere with the mesoporous structure as claimed in claim 1 , wherein the surface-bound functional groups are —(CH)—SH claim 1 , or —(CH)—CN.4. The hollow sphere with the mesoporous structure as claimed in claim 1 , wherein particle size of the hollow sphere is 50-300 nm. This application claims the benefits of the Taiwan Patent Application Ser. No. 100110568, filed on Mar. 18, 2011, the subject matter of which is incorporated herein by reference.1. Field of the InventionThe present invention relates to a hollow sphere with a mesoporous structure and a method for ...

Compositions for endodontic procedures

An adhesion promoter for endodontic sealant compositions for filling and sealing a root canal.

ORGANIC COMPOUNDS

The present invention provides heterocyclic derivatives that modulate the activity of stearoyl-CoA desaturase. Methods of using such derivatives to modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives are also encompassed. 2. A pharmaceutical composition claim 1 , comprising the compound of formula (I) according to and a pharmaceutically acceptable excipient or carrier.4. A method of treating a disease or condition mediated by stearoyl-CoA desaturase (SCD) in a mammal claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'administering to the mammal in need thereof a therapeutically effective amount of a compound of Formula (I) according to .'}5. A pharmaceutical composition claim 1 , comprising:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'a therapeutically effective amount of a compound of in combination with a therapeutically effective amount of insulin, insulin derivative or mimetic; insulin secretagogue; insulinotropic sulfonylurea receptor ligand; PPAR ligand; insulin sensitizer; biguanide; alpha-glucosidase inhibitors; GLP-1, GLP-1 analog or mimetic; DPPIV inhibitor; HMG-CoA reductase inhibitor; squalene synthase inhibitor; FXR or LXR ligand; cholestyramine; fibrates; nicotinic acid; or aspirin.'} The present invention relates generally to the field of inhibitors of stearoyl-CoA desaturase, such as heterocyclic derivatives, and uses for such compounds in treating and/or preventing various human diseases, including those mediated by stearoyl-CoA desaturase (SCD) enzymes, preferably SCD1, especially diseases related to elevated lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome, dermatological disorders and the like.Acyl desaturase enzymes catalyze the formation of a double bond in fatty acids derived from either dietary sources or de novo synthesis in the liver. In mammals, at least three fatty acid desaturases exists, each with differing specificity: delta-9 ...

INDUSTRIAL PROCESS FOR THE PREPARATION OF N-ALKYL-N-TRIALKYLSILYLAMIDES

The present invention relates to a process for producing N-alkyl-N-trialkylsilylamides from trialkylsilylhalides and N-alkylamides in the presence of a base and in the absence of a solvent. 2. The process according to claim 1 , wherein 0.8 to 2 moles of the organic base [OB] are used per mole of the compound of formula II.3. The process according to claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , Rand Rindependently of each other represent C-Calkyl which can be identical or different.4. The process according to claim 3 , wherein R claim 3 , R claim 3 , R claim 3 , Rand Rindependently of each other represent Cor Calkyl which can be identical or different.5. The process according to claim 1 , wherein R claim 1 , R claim 1 , R claim 1 , Rand Rare the same.6. The process according to claim 5 , wherein R claim 5 , R claim 5 , R claim 5 , Rand Rrepresent methyl.7. The process according to any one of claim 1 , wherein X represents chlorine.8. The process according to claim 1 , wherein the organic base [OB] is a nitrogen containing organic base.9. The process according to claim 1 , wherein the compound of formula I is separated from the salt of the organic base [OB]HXby adding an antisolvent for [OB]HXto the reaction medium so that the salt of the organic base [OB]HXprecipitates and can be removed by filtration.10. The process according to claim 9 , wherein the antisolvent is an alkane having a boiling point in the range from 35 to 80° C.11. The process according to claim 1 , wherein the compound of formula II is reacted with the compound of formula III in a compound of formula II/compound of formula III molar ratio of 1/5 to 5/1.12. The process according to claim 1 , wherein the reaction of the compound of formula II with the compound of formula III is carried out at a temperature in the range from 20 to 50° C.13. A process for the manufacture of a peptide or peptide analogue which comprises{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, 'preparing a compound of ...

Process for the Syntheses of Triazoles

The present invention relates to processes for the preparation of triazoles. These compounds are useful as anti-infective, anti-proliferative, anti-inflammatory, and prokinetic agents.

ORGANOZINC COMPLEXES AND PROCESSES FOR MAKING AND USING THE SAME

Processes for making an organozinc reagents are disclosed comprising reacting (A) organomagnesium or organozinc complexes with (B) at least one coordination compound comprising one or more carboxylate groups and/or alcoholate groups and/or tertiary amine groups, optionally in combination with zinc ions and/or lithium ions and/or halide ions, wherein the halide ions are selected from chloride, bromide and iodide, the organozinc complex comprises an aryl group, a heteroaryl group or a benzyl group when the coordinating compound is a chelating polyamine, and the reaction is conducted in the presence of zinc complexed with at least one coordinating compound when reactant (A) comprises at least one organomagnesium complex. The resulting organozinc reagents may optionally be isolated from solvents to obtain a solid reagent. The reagents may be used for making organic compounds via Negishi cross-coupling reactions or via aldehyde and/or ketone oxidative addition reactions. The organozinc reagents are stable and, due to their high selectivity, permit maintenance of sensitive functional groups such as aldehydes during cross-coupling. 1. A process for making organozinc reagents comprising:(1) reacting (A) at least one organomagnesium complex or organozinc complex with (B) at least one coordinating compound comprising one or more carboxylate groups and/or alcoholate groups and/or tertiary amine groups, optionally in combination with zinc ions and/or lithium ions and/or halide ions, wherein the halide ions are selected from chloride, bromide and iodide, the organozinc complex comprises an aryl group, a heteroaryl group or a benzyl group when the coordinating compound is a chelating polyamine, and the reaction is conducted in the presence of zinc complexed with at least one coordinating compound when reactant (A) comprises at least one organomagnesium complex,(2) contacting an organic compound having at least one leaving group with magnesium metal and a zinc coordination complex ...

PROCESS FOR PRODUCTION OF MESO-FORM AND RACEMIC FORM METALLOCENE COMPLEXES

A method for producing an anionized meso-form double-cross-linked ligand represented by formula (3), including: bringing a compound represented by formula (1) into contact with a compound represented by formula (2) at −25° C. or less; and introducing an anionizing agent within 5 hours after the contact, wherein Rto Rare independently a hydrogen atom, a hydrocarbon group having 1 to 20 carbon atoms, or the like; A and A′ are independently a cross-linking group containing an atom belonging to the 14group of the periodic table; M and M′ are independently an atom belonging to the 1or the 2group of the periodic table. 3. The production method according to claim 1 , wherein A is dimethyl silylene or tetramethyl disilylene and A′ is dimethyl silylene or tetramethyl disilylene.4. A method for producing a double-cross-linked metallocene complex claim 1 , the method comprising forming a double-cross-linked metallocene complex from an anionized meso-form double-cross-linked ligand of formula (3) produced by the method of .5. The production method according to claim 2 , wherein A is dimethyl silylene or tetramethyl disilylene and A′ is dimethyl silylene or tetramethyl disilylene.6. A method for producing a double-cross-linked metallocene complex claim 2 , the method comprising forming a double-cross-linked metallocene complex from an anionized racemic-form double-cross-linked ligand of formula (4) produced by the method of . The invention relates to a meso-form and racemic-form double-cross-linked complexes, and a method for producing these double-cross-linked metallocene complexes.Various attempts have been made to obtain an olefin polymer of which the primary structure, the molecular weight or the like are controlled by changing variously the structure of a metallocene complex structure (Patent Documents 1 and 2, Non-Patent Documents 1 and 2). Of the structures of a metallocene complex, the effect of symmetry of a metallocene complex (racemic-form (C2 symmetric), meso-form ( ...

SILICON-CONTAINING CARBOXYLIC ACID DERIVATIVE

A compound represented by the formula (I) [Rto Rrepresent an alkyl group, an alkenyl group, and the like; n represents 0 or 1; Rrepresents an amino group or —(CX)—COOH (m represents 0 to 3, and X represents hydrogen atom); Rrepresents —(CY)—COOR(p represents an 0 to 3, Y represents hydrogen atom, and Rrepresents hydrogen atom or an alkyl group)], or a salt thereof. 2. The compound or a salt thereof according to claim 1 , wherein R claim 1 , R claim 1 , and Rare independently an alkyl group or an aryl group claim 1 , n is 0 or 1 claim 1 , Ris unsubstituted amino group claim 1 , a monoalkylamino group claim 1 , or an acylamino group claim 1 , and Ris —(CH)—COOR(p represents an integer of 0 to 3 claim 1 , and Ris hydrogen atom or an alkyl group).3. The compound or a salt thereof according to claim 1 , wherein R claim 1 , R claim 1 , and Rare independently an alkyl group claim 1 , n is 0 claim 1 , Ris unsubstituted amino group claim 1 , a monoalkylamino group claim 1 , or an acylamino group claim 1 , and Ris —(CH)—COOR(p is 1 claim 1 , and Ris hydrogen atom or an alkyl group). The present invention relates to a silicon-containing carboxylic acid derivative.Carboxyl group is one of important functional groups in pharmaceutical compounds, and is widely used in combination with various functional groups, such as amino group, hydroxyl group, and a halogen atom. For example, gabapentin (2-[1-(aminomethyl)cyclohexyl]acetic acid) used an antiepileptic, and pregabalin ((S)-3-(aminomethyl)-5-methylhexanoic acid) used for peripheral neuropathic pains (postherpetic neuralgia and the like) are examples of medicaments having carboxyl group and amino group in combination.There have been proposed pharmaceutical compounds consisting of a carboxylic acid derivative in which a carbon atom is replaced with a silicon atom. For example, a β-carbonylsilane compound having a silicon atom as a ring-constituting atom in a ring system such as 6-membered ring has been proposed as an analogue of ...

PATTERNED FINE PARTICLE FILM STRUCTURES

A patterned fine particle film structure includes a fine particle layer including fine particles arranged and bound to a surface of a substrate coated with a patterned film including a first film compound having a first functional group. The fine particles are coated with films including a first coupling agent having a first coupling reactive group that undergoes a coupling reaction with the first functional group to form a bond. The fine particle layer is bound by a bond formed through a coupling reaction. In an embodiment, fine particles coated with films of a film compound that reacts with the first coupling reactive group and the fine particles are alternately bound to the substrate. 1. A method of forming a film structure , the method comprising:linking a first linker to a substrate such that the first linker extends a first reactant product away from the substrate;linking a second linker to a particle such that the second linker extends a second reactant product away from the particle; andcoupling the first reactant product of the first linker to the second reactant product of the second linker with a coupling agent so as to link the particle to the substrate, wherein the coupling agent reacts with the first linker and second linker.2. The method of claim 1 , wherein:linking the first linker to the substrate comprises linking the first linker to the substrate through one or more first active hydrogen groups of the substrate; andlinking the second linker to the particle comprises linking the second linker to the particle through one or more second active hydrogen groups of the particle.3. The method of claim 1 , wherein coupling the first reactant product of the first linker to the second reactant product of the second linker comprises:reacting an epoxide of the first linker with an amine or imine of the coupling agent; andreacting an epoxide of the second linker with an amine or imine of the coupling agent, wherein the coupling agent has both an amine and an ...

Novel Bicyclic Pyridinones

Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I 2. The compound according to wherein X is imidazolyl claim 1 , pyrazolyl claim 1 , isothiazolyl claim 1 , thiazolyl claim 1 , isoxazolyl claim 1 , oxazolyl or pyridyl.3. The compound according to wherein X is imidazolyl.4. The compound according to wherein Ris Calkyl.5. The compound according to wherein Ris methyl optionally substituted with one hydroxyl or Calkoxy or one to three fluoro; y is two or three and z is 1.6. The compound according to wherein Ris independently hydrogen claim 5 , halogen claim 5 , cyano claim 5 , —CF claim 5 , Calkyl claim 5 , (C)bicycloalkyl claim 5 , —(C(R))—(Ccycloalkyl) claim 5 , —(C(R))-(4- to 10-membered heterocycloalkyl) claim 5 , —(C(R))—(Caryl) claim 5 , —(C(R))-(5- to 10-membered heteroaryl) claim 5 , —(C(R))—ORor —C(O)R; wherein the alkyl claim 5 , cycloalkyl claim 5 , bicycloalkyl claim 5 , heterocycloalkyl claim 5 , aryl claim 5 , or heteroaryl moieties may be independently substituted with one to three R.7. The compound according to wherein Ris independently hydrogen claim 6 , Calkyl claim 6 , fluoro claim 6 , —CF claim 6 , —CHFor —OR; and Ris hydrogen claim 6 , Calkyl claim 6 , —CFor Caryl.8. The compound according to wherein Ris phenyl claim 7 , naphthalene claim 7 , 2 claim 7 ,3-dihydro-1H-indene claim 7 , quinoline claim 7 , isoquinoline claim 7 , pyrazole claim 7 , benzo[b]furan claim 7 , 2 claim 7 ,3-dihydrobenzofuran claim 7 , 1 claim 7 ,2-benzisothiazole claim 7 , 1 claim 7 ,3-benzothiazole claim 7 , benzofuro[3 claim 7 ,2-c]pyridine claim 7 , pyridine claim 7 , carbazole claim 7 , benzo[d]isoxazole claim 7 , benzocyclobutane claim 7 , 1 claim 7 ,2 claim 7 ,3 claim 7 ,4-tetrahydronaphthalene claim 7 , dibenzo[b claim 7 ,d]thiophene claim 7 , dibenzo[b claim 7 ,d]furan or cinnoline.9. The compound according to wherein Ris hydrogen claim 8 , chloro claim 8 , fluoro claim 8 , bromo claim 8 ...

SILICON COMPOUNDS DERIVED FROM FURFURYL ALCOHOLS AND METHODS OF PREPARATION

Novel silicon compounds containing a siloxane or silane moiety and at least one moiety derived from a furfuryl alcohol, and methods for their synthesis, are provided. The novel compounds may be used as surface modifying agents, surfactants, defoamers, and as monomers for silicone polymerization. 1. A silicon compound or siloxane polymer comprising a siloxane moiety and at least one furfuryl alcohol-derived moiety.2. The compound according to claim 1 , further comprising an alkyl group bridging the siloxane or silane moiety and the furfuryl alcohol-derived moiety.3. The compound according to claim 2 , wherein the alkyl group comprises about three carbon atoms.4. The compound according to claim 1 , wherein the furfuryl alcohol is tetrahydrofurfuryl alcohol.6. The compound according to claim 5 , wherein m=3 claim 5 , n=0 claim 5 , and every X═H.8. The compound according to claim 1 , wherein the silicon compound is tetrahydrofurfuryloxypropylheptamethyltrisiloxane.10. A surface modifying reagent comprising a silicon compound according to .11. A surfactant comprising a silicon compound according to .12. The compound according to claim 1 , wherein the compound is a siloxane polymer containing a tetrahydrofurfuryloxyalkyl substitution.13. The compound according to claim 1 , wherein the silicon compound is a (tetrahydrofurfuryloxypropyl)methylsiloxane-dimethylsiloxane copolymer.14. The compound according to claim 1 , wherein the silicon compound is selected from the group consisting of a (tetrahydrofurfuryloxypropyl)methylsiloxane-dimethylsiloxane-methylhydrogensiloxane terpolymer and a (tetrahydrofurfuryloxypropyl)methylsiloxane-dimethylsiloxane-methylvinylsiloxane terpolymer.15. An elastomeric and cross-linked product derived from at least one terpolymer according to .16. The compound according to claim 1 , wherein the silicon compound is a siloxane homopolymer or copolymer having a hydride or vinyl terminal group.17. An elastomeric and cross-linked product derived from ...

Dehydrogenative Silylation and Crosslinking Using Cobalt Catalysts

Disclosed herein are cobalt complexes containing terdentate pyridine di-imine ligands and their use as efficient and selective dehydrogenative silylation and crosslinking catalysts. 3. The process of further comprising removing the complex and/or derivatives thereof from the dehydrogenative silylated product.4. The process of wherein the dehydrogenatively silylated product comprises a silane or siloxane containing a silyl group and an unsaturated group.5. The process of claim 4 , wherein the unsaturated group is in the alpha or beta position relative to the silyl group.6. The process of wherein the molar ratio of the unsaturated group in said component (a) relative to the silylhydride functional group in said component (b) is less than equal to 1:1.7. The process of wherein the silane or siloxane of the dehydrogenatively silylated product contains one silyl group derived from component (b).8. The process of wherein the dehydrogenatively silylated product contains two or more terminal silyl groups derived from component (b).9. The process of claim 6 , wherein said process produces an α claim 6 ,ω-substituted alkane or alkene diol from a parent α claim 6 ,ω-bis(silyl) substituted alkane or alkene.10. The process of wherein the molar ratio of the unsaturated group in said component (a) relative to the silylhydride functional group in said component (b) is greater than 1:1.11. The process of wherein the silane or siloxane contains two or more silyl groups derived from component (b).12. The process of wherein said component (a) is a mono-unsaturated compound.13. The process of wherein said component (a) is selected from the group consisting of an olefin claim 1 , a cycloalkene claim 1 , an alkyl-capped allyl polyether claim 1 , a vinyl-functional alkyl-capped allyl or methallyl polyether claim 1 , an alkyl-capped terminally unsaturated amine claim 1 , an alkyne claim 1 , terminally unsaturated acrylate or methacrylate claim 1 , unsaturated aryl ether claim 1 , vinyl- ...

Novel Photoactive Polymers

This disclosure relates to a photovoltaic cell that includes a first electrode, a second electrode, and a photoactive layer disposed between the first and second electrodes. The photoactive layer includes a photoactive polymer containing a first monomer repeat unit, which contains a moiety of formula (1): in which A and R are defined in the specification.

Fluorescent probe

A compound represented by the formula (I) (one of substituents represented by R 1 is a trapping group for an object substance for measurement; R 2 and R 3 represent hydrogen, alkyl, or halogen; R 4 and R 5 represent alkyl or aryl; R 6 and R 7 represent hydrogen, alkyl, or halogen; R 8 represents hydrogen, alkylcarbonyl, or alkylcarbonyloxymethyl, and X represents silicon, germanium, or tin, which can be used as a fluorescent probe that enables red color bioimaging using intramolecular photoinduced electron transfer.

NITRIC OXIDE-RELEASING NANORODS AND THEIR METHODS OF USE

In one aspect, the subject matter disclosed herein is directed to NO-releasing functionalized nanorods having a desirable aspect ratio. The nanorods are also capable of releasing a desirable amount of NO (nitric oxide). In another aspect, the subject matter disclosed herein is directed to a composition comprising the NO-releasing nanorods. In another aspect, the subject matter disclosed herein is directed to methods of preparing NO-releasing nanorods having a specified aspect ratio. In another aspect, the subject matter disclosed herein is directed to a method of combating infection comprising administering to a subject a composition comprising NO-releasing nanorods, wherein the nanorods have a specified aspect ratio and NO-release profile. 1. A nitric oxide-releasing nanorod comprising ,i. a silane, andii. a functionalized mono, di or trialkoxysilane,wherein said functionalized mono, di or trialkoxysilane comprises a NO-donor molecule;{'sub': 'max', 'wherein said nanorod has an aspect ratio of at least 1 and a [NO]of at least about 10 ppb/mg.'}2. The nanorod of claim 1 , wherein said nanorod is mesoporous.3. The nanorod of claim 2 , wherein said mesoporous nanorod comprises pores having sizes from about 2 nm to about 50 nm in diameter.4. The nanorod of claim 1 , wherein said silane has the formula Si(OR) claim 1 , wherein R is a Calkyl.5. The nanorod of claim 4 , wherein said silane is TEOS or TMOS.6. The nanorod of claim 1 , wherein said silane is selected from the group consisting of methyltrimethoxysilane (MTMOS) claim 1 , ethyltrimethoxysilane (ETMOS) claim 1 , butyltrimethoxysilane (BTMOS) claim 1 , propyltrimethoxysilane (PTMOS) claim 1 , butyltriethoxysilane (BTEOS) claim 1 , and octadecyltrimethoxysilane (ODTMOS).7. The nanorod of claim 4 , wherein said functionalized mono claim 4 , di or trialkoxysilane is a nitric oxide functionalized N-(2-aminoethyl)-3-amino-isobutyl-dimethylmethoxysilane (AEAI); aminopropyldimethylethoxysilane (APDE); N-(6-aminohexyl) ...

Pyrazole derivatives, preparation method thereof, and composition for prevention and treatment of osteoporosis containing same

The present invention provides pyrazole derivative compounds and pharmaceutically acceptable salts thereof. The compounds of the present invention have an excellent effect of preventing and treating osteoporosis.

DIRECT TRIFLUOROMETHYLATIONS USING TRIFLUOROMETHANE

A direct trifluoromethylation method preferably using a trifluoromethane as a fluoro-methylating species. In particular, the present method is used for preparing a trifluoromethylated substrate by reacting a fluoromethylatable substrate with a trifiuoromethylating agent in the presence of an alkoxide or metal salt of silazane under conditions sufficient to trifluoromethylate the substrate; wherein the fluoromethylatable substrate includes chlorosilanes, carbonyl compounds such as esters, aryl halides, aldehydes, ketones, chalcones, alkyl formates, alkyl halides, aryl halides, alkyl borates, carbon dioxide or sulfur. 1. A method for preparing a trifluoromethylated product , which comprises reacting a fluoromethylatable substrate with a trifluoromethylating agent in the presence of a base under conditions sufficient to trifluoromethylate the substrate; wherein the fluoromethylatable substrate comprises a compound selected from the group consisting of chlorosilanes , carbonyl compounds such as esters , aryl halides , aldehydes , ketones , chalcones , alkyl formates , alkyl halides , aryl halides , alkyl borates , carbon dioxide and sulfur.2. The method of claim 1 , wherein the trifluoromethylating agent is trifluoromethane.3. The method of claim 1 , wherein the substrate comprises chlorotrimethylsilane claim 1 , chlorotriethylsilane claim 1 , chlorotriisopropylsilane claim 1 , chloro(t-butyldimethyl)silane claim 1 , chloro(tris(trimethylsilyl)) silane claim 1 , dichlorodiethylsilane claim 1 , benzaldehyde claim 1 , p-anisaldehyde claim 1 , 3-methylbenzaldehyde claim 1 , 1-anthracenaldehyde claim 1 ,furan-2-carboxaldehyde claim 1 , benzophenone claim 1 , 4-methoxybenzophenone claim 1 , 4-methylbenzophenone claim 1 , 3-nitrobenzophenone claim 1 , 4-fluorobenzophenone claim 1 , chalcone claim 1 , 4′-methoxychalcone claim 1 , 4′-nitrochalcone claim 1 , 4 claim 1 ,4′-difluorochalcone claim 1 , 4′-chlorochalcone claim 1 , methyl benzoate claim 1 , benzyl bromide claim 1 , ...