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Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

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Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

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Применить Всего найдено 39290. Отображено 100.
05-01-2012 дата публикации

Intermediates Useful in the Preparation of Maleimide Functionalized Polymers

Номер: US20120004422A1
Автор: Antoni Kozlowski, Brian Bray, Samuel P. McManus, Tracy L. Hutchison, Xiaoming Shen
Принадлежит: Nektar Therapeutics

Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.

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Номер записи: 1
26-01-2012 дата публикации

Natural oil polyols in elastomers for tires

Номер: US20120018066A1
Автор: Kandathil E. Verghese, Rui Xie, Syed A. Shah
Принадлежит: Dow Global Technologies LLC

Prepolymers having active NCO groups are disclosed. The prepolymers are the reaction product of at least one polyisocyanate and a polyhydric component which comprises at least one dimer fatty derivative diol or diamine that is a natural oil based polyol or polyamine which includes the derivative of at least one dimer fatty acid. Polyurethane and polyurea elastomer obtained from the prepolymers are also disclosed. Also disclosed are methods of manufacturing polyurethane or polyurea treaded tires.

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Номер записи: 2
16-02-2012 дата публикации

Surfactants in Agrochemical Formulations

Номер: US20120040834A1
Автор: Gregory James LINDNER, Lee David Richards, Trevor Graham Blease
Принадлежит: Croda Inc, Croda International PLC

Surfactant compounds which include an amine ended polyalkylene glycol hydrophile linked to C 22 to C 60 mainly hydrocarbyl, particularly composite hydrocarbyl, especially derived from a polymerised fatty acid and/or an aralkyl substituted phenol, hydrophobe, are useful in dispersing solids, particularly active agrochemicals, in aqueous media, or as adjuvants in agrochemical formulations, particularly of water soluble non-selective herbicides. In particular the hydrophobe is derived from polymerised fatty acids, such as dimer and, especially, trimer acids or from aralkyl substituted phenols. Aqueous dispersions using such surfactants can remain stable even with substantial concentrations of electrolyte e.g. in stable agrochemical dispersions including water soluble electrolyte agrochemical, such as glyphosate and/or ammonium sulphate.

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Номер записи: 3
16-02-2012 дата публикации

Dispersant Comprising Copolymer Mixture

Номер: US20120041104A1
Автор: Barbara Wimmer, Christian Scholz, Klaus Lorenz, Mario Vierle, Petra Wagner
Принадлежит: CONSTRUCTION RESEARCH AND TECHNOLOGY GmbH

The invention relates to a polymer composition containing 3 to 95% by weight of a copolymer H and 3 to 95% by weight of a copolymer K, the copolymers H and K each having polyether macromonomer structural units and acid monomer structural units, which are present in the copolymers H and K in each case in a molar ratio of 1:20 to 1:1, and at least 20 mol % of all structural units of the copolymer H and at least 25 mol % of all structural units of the copolymer K being present in each case in the form of acid monomer structural units, the polyether macromonomer structural units of the copolymers H and K having side chains containing in each case at least 5 ether oxygen atoms, the number of ether oxygen atoms per side chain of the polyether macromonomer structural units of the copolymers H and K varying in each case in such a way that the corresponding frequency distribution diagrams, in which the number of ether oxygen atoms per side chain of a polyether macromonomer structural unit is plotted in each case along the abscissae and the respectively associated frequencies for the copolymers H or K are plotted in each case along the ordinates, contain in each case at least 2 maxima whose abscissa values differ in each case by more than 7 ether oxygen atoms from one another, the frequency distribution diagrams of the copolymers H and K differing from one another in that the abscissa value of at least one maximum of the copolymer H differs in each case by more than 5 ether oxygen atoms from the abscissa values of all maxima of the copolymer K and/or that the arithmetic means of the ether oxygen atoms of the polyether macromonomer structural units of the copolymers H and K differ from one another by more than 5 ether oxygen atoms.

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Номер записи: 4
08-03-2012 дата публикации

Process for the purification of polyol PFPE derivatives

Номер: US20120055779A1
Автор: Claudio Adolfo Pietro Tonelli, Fabrizio Mutta, Graziano Giuseppe Vezzulli, Piero Gavezotti
Принадлежит: Solvay Solexis SpA

A process for purifying a polyol (per)fluoropolyether derivative [polyol (P)] from a mixture of hydroxyl (per)fluoropolyether derivatives [mixture (M)]. Such polyol (P) comprising one or more hydroxyl (per)fluoropolyether derivatives [PFPE (OH)] comprising at least one (per)fluoropolyoxyalkylene chain (chain R f ) and at least one end-group having formula (t 3 )-CF 2 CH 2 OCH 2 CH(OH)CH 2 OCH 2 CH(OH)CH 2 OH. Such mixture (M) comprising the polyol (P) and at least one PFPE (OH) different from the polyol (P) and comprising at least one chain R f and at least one end-group selected from end-groups having formula (t 1 )-CF 2 CH 2 OH and formula (t 2 )-CF 2 CH 2 OCH 2 CH(OH)CH 2 OH. The process comprises the steps of: 1) reacting the mixture (M) with a ketone, an aldehyde or a combination thereof to yield corresponding mixture of cyclic ketal/acetal (per)fluoropolyether derivatives [PFPEs (OH) p ] [protected mixture (P)]; 2) carrying out a molecular distillation of the protected mixture (P) to isolate a protected product heavy residue [product (P r )]; 3) hydrolyzing the product (P r ) to yield deprotected product [product (P d ]); and 4) carrying out a distillation under reduced pressure of the product (P d ) to obtain polyol (P).

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Номер записи: 5
08-03-2012 дата публикации

Novel Copolymers for Use as Oilfield Demulsifiers

Номер: US20120059088A1
Автор: Christine Ann Blundell, Darryl M. Stepien, Matthew Hilfiger, Michael P. Squicciarini, Patrick J. Breen
Принадлежит: Baker Hughes Inc

Lactone/alkylene oxide polymers are useful as demulsifiers to break emulsions, e.g. water-in-oil and oil-in-water emulsions, particularly oilfield emulsions. These polymers are random or block polymer made from addition reactions of a hydroxyl- and/or amine-containing base compound with at least one lactone monomer and at least one alkylene oxide monomer.

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Номер записи: 6
19-04-2012 дата публикации

Molecularly Imprinted Polymers for Use as Imaging and Therapeutics Agents

Номер: US20120093720A1
Автор: Robert Jones, Thomas Beck
Принадлежит: Individual

The invention described herein provides biocompatible molecularly imprinted polymers (MIPs) that are non-toxic, water soluble, small molecular weight, and degradable in a living body. The MIPs are capable of binding to all or a portion of a specific target macromolecule associated with a disease located within the living body and they are derivatized for stealth for in vivo applications to avoid the reticuloendothelial system. The MIPs of the invention are functionalized to an amine or carboxyl group and are derivatized with an imaging and/or therapeutic agent for taking images of the disease and/or for providing therapy. The macromolecule can be selected from a group consisting of proteins, glycoproteins, lipoproteins, peptidoglycans, peptides, polypeptides, polynucleotides, and polysaccharides. The invention described herein also provides methods and kits wherein MIPs of the invention can be employed as targeted imaging and therapeutic agents.

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Номер записи: 7
03-05-2012 дата публикации

Segmented polyarylene ether block copolymers

Номер: US20120108693A1
Автор: Cecile Gibon, Martin Weber, Ranimol Stephen, Reinoud J. Gaymans
Принадлежит: BASF SE

The present invention relates to polyarylene ether block copolymers according to the general formula A-K-X-K-A, where —X— is a polyarylene ether segment with number-average molar mass of at least 5000 g/mol, and A— is a segment of the general structure R2NH—(R1—NH—CO—Ar—CO—NH)n—R1—NH—, in which R1 is a linear or branched alkylene group having from 2 to 12 carbon atoms and Ar is an arylene group having from 6 to 18 carbon atoms, and R2 is selected from aryloyl, alkyloyl, and H, and in which the number average of n is from 1 to 3, and there is a coupling group K of the structure —CO—Ar3—CO— linking each A to X, in which Ar3 is an aromatic group having from 6 to 18 carbon atoms. The present invention also relates to a process for the production of the polyarylene ether block copolymers of the invention, to polymer compositions comprising the polyarylene ether block copolymers of the invention, and also to the use thereof for the production of moldings, of films, of fibers, or of foams.

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Номер записи: 8
10-05-2012 дата публикации

Polymer Conjugates with Decreased Antigenicity, Methods of Preparation and Uses Thereof

Номер: US20120114742A1
Автор: Alexa L. Martinez, L. David Williams, Mark G.P. Saifer, Merry R. Sherman
Принадлежит: Mountain View Pharmaceuticals Inc

Methods are provided for the preparation of conjugates of a variety of bioactive components, especially proteins, with water-soluble polymers (e.g., poly(ethylene glycol) and derivatives thereof), which conjugates have reduced antigenicity and immunogenicity compared to similar conjugates prepared using poly(ethylene glycol) containing a methoxyl or another alkoxyl group. The invention also provides conjugates prepared by such methods, compositions comprising such conjugates, kits containing such conjugates or compositions and methods of use of the conjugates and compositions in diagnostic and therapeutic protocols.

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Номер записи: 9
10-05-2012 дата публикации

Detergent composition

Номер: US20120115769A1
Автор: Hisato Fukuda, Katsuhisa Inoue, Masato Nomura
Принадлежит: Kao Corp

The present invention relates to the detergent composition, containing (a) a nonionic surfactant represented by the formula (1); and (b) a sulfuric acid ester salt represented by the formula (2): R—O-(EO) m —(PO) n -(EO) m′ —H  (1) wherein, R represents a hydrocarbon group having 6 to 24 carbon atoms; EO represents an ethyleneoxy group; PO represents a propyleneoxy group; m=0.1 to 25; m′=0 to 24.9; m+m′=0.5 to 25; and n=0.1 to 10; with the proviso that (EO) m , (PO) n , and (EO) m′ are arranged in a block addition mode in this order; R 1 —O—(PO) x -(EO) y —SO 3 M  (2) wherein, R 1 represents a hydrocarbon group having 6 to 24 carbon atoms; x=0.1 to 10; y=0 to 30; (PO) x and (EO) y are arranged in any order in any addition mode, being a block addition or a random addition, M is a counter ion.

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Номер записи: 10
17-05-2012 дата публикации

Thermosetting fluoropolyether adhesive composition and adhesion method

Номер: US20120123049A1
Автор: Hidenori Koshikawa, Mikio Shiono
Принадлежит: Shin Etsu Chemical Co Ltd

A thermosetting fluoropolyether adhesive composition is provided. This composition cures at lower than 100° C., and the cured product exhibits good adhesion to various substrates and excellent adhesion durability at a temperature of up to 150° C. A method for adhering the composition to the substrate is also provided. The composition comprises (A) a straight chain polyfluoro compound, (B) a fluorine-containing organohydrogenpolysiloxane containing at least 2 SiH groups and not containing other functional group, (C) a platinum group metal catalyst, (D) a fluorine-containing organohydrogenpolysiloxane containing a fluorine-containing organic group, SiH group, epoxy group and/or tri(organoxy)silyl group, and an aryl group, (E) a polyhydric allyl ester compound, (F) an organosilicon compound having epoxy group and an organoxy group, and not containing SiH group, and (G) an organosilicon compound having SiH group and an aryl group, and not containing epoxy group or a tri(organoxy)silyl group, or a fluorine-containing organic group.

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Номер записи: 11
24-05-2012 дата публикации

Process for the preparation of polyetherols from alkylene oxides

Номер: US20120130134A1
Автор: Achim Loeffler, Dirk Meckelnburg, Eckard Schauss, Hans Volkmar Schwarz, Hans-Juergen Pallasch, Matthias Schopohl, Renata Jovanovic, Susanne Szeschkus, Thomas Ostrowski, Thorsten Friese, Vinit Chilekar
Принадлежит: BASF SE

A process for the preparation of polyetherols, comprising the following steps: a) reaction of at least one starter compound with at least one alkylene oxide and a catalyst to give a crude polyetherol and b) removal of low molecular weight byproducts from the crude polyetherol from step a), wherein the crude polyetherol is treated with a stripping gas in a column having internals.

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Номер записи: 12
07-06-2012 дата публикации

Charging member, process cartridge and electrophotographic apparatus

Номер: US20120141159A1
Автор: Noriaki Kuroda, Noriko Nagamine, Yuya Tomomizu
Принадлежит: Canon Inc

A charging member is provided with a surface layer that can not easily wear even due to its contact with a photosensitive member and also has an appropriate elasticity contributing to the formation of an appropriate nip between it and the photosensitive member. The charging member has a substrate, an elastic layer and a surface layer; the surface layer containing a high-molecular compound having an Si—O—Hf linkage and having a constitutional unit represented by the formula (1) and a constitutional unit represented by the formula (2):

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Номер записи: 13
14-06-2012 дата публикации

Novel method for producing polyphenylene ether

Номер: US20120149853A1
Автор: Hiroaki Furukawa, Mutsumi Maeda
Принадлежит: Asahi Kasei Chemicals Corp

Method for producing polyphenylene ether, comprising preparing a polymerization solution of 10-25 parts by mass of a phenolic compound (M) and 75-90 parts by mass of an aromatic solvent (A) with the total of the compound and the solvent being 100 parts by mass, and 0.1-10 parts by mass of a catalyst (C) containing a metal salt; performing oxidative polymerization of the phenolic compound (M) by passing oxygen-containing gas through polymerization solution; stopping polymerization by mixing aqueous chelating agent solution into polymerization solution; subjecting a diphenoquinone compound produced as a by-product to quinone binding process or removal by reduction; and obtaining polyphenylene ether by separating aqueous phase through liquid-liquid separation. In the method for producing a polyphenylene ether, 0.001-0.004 part by weight of an ion catalyst (D) is added into the polymerization solution before the liquid-liquid separation.

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Номер записи: 14
28-06-2012 дата публикации

Glue for repair or attachment free of organotin

Номер: US20120165453A1
Автор: Jacqueline Carrard, Virginie Cagan
Принадлежит: BOSTIK SA

The invention relates to an adhesive composition, including: 10 to 95% of a moisture cross-linkable polymer (A), the main chain includes 2 silyl terminal groupings, each of which includes at least one hydrolyzable group bonded to the silicon atom; 1 to 60% of a mineral filler (B) in the form of particles having a size of between 1 nm and 0.2 mm; and 0.2 to 7% of a cross-linking catalyst (C) consisting of titanium tetraisopropoxide. The invention also relates to the use of said composition as glue for repair or attachment.

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Номер записи: 15
28-06-2012 дата публикации

Isocyanate-free silane-crosslinking compounds

Номер: US20120165493A1
Автор: Andreas Bauer, Bernd-Josef Bachmeier, Volker Stanjek
Принадлежит: Wacker Chemie AG

The invention relates to compounds (K) comprising A) 100 parts by weight of a pre-polymer (P) comprising units (E) in the backbone thereof that are selected from polyether and polyester units, wherein the pre-polymer (P) comprises at least one end group of the general formula (1) -L 1 -(CH 2 ) y —SiR 2 3-x (OR 1 ) x (1), B) 1 to 100 parts by weight of silane (S) of the general formula (2) R 4 SiR 2 3-Z (OR 1 ) z (2), (G) 0 to 10 parts by weight of a curing catalyst (HK) that accelerates the curing of the compounds (K) in the presence of humidity, wherein L 1 represents a divalent linking group selected from —O—, —S—, —(R 3 )N—, —O—CO—N(R 3 )—, —N(R 3 )—CO—O—, —N(R 3 )—CO—NH—, —NH—CO—N(R 3 )—, —N(R 3 )—CO—N(R 3 ) and R 1 , R 2 , R 3 , x, y and z have the meanings cited in claim 1. R 4 are hydrocarbon radicals having at least 7 hydrogen atoms. According to the invention, after hardening, the compounds (K) have high shear strength and are used as adhesives (K).

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Номер записи: 16
05-07-2012 дата публикации

Process for producing polyether

Номер: US20120172537A1
Автор: Chitoshi Suzuki, Takeaki Arai
Принадлежит: Asahi Glass Co Ltd

To provide a process for producing a polyether, which comprises subjecting an alkylene oxide and the like to ring-opening addition polymerization to an initiator in the presence of a double metal cyanide complex catalyst (DMC catalyst), which can be carried out by use of a DMC catalyst at a low concentration, and accordingly the amount of the DMC catalyst remaining in a polyether to be obtained can be reduced. A process for producing a polyether, which comprises subjecting an alkylene oxide and an oxygen-containing heterocyclic compound other than an alkylene oxide, to ring-opening addition polymerization to an initiator having a hydroxy group in the presence of a DMC catalyst, wherein prior to the ring-opening addition polymerization, the DMC catalyst and the initiator are subjected to mixing treatment at a temperature of from 125° C. to 180° C. under an absolute pressure of at most 0.06 MPa for from 10 minutes to 24 hours.

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Номер записи: 17
12-07-2012 дата публикации

Reactive diluents containing silane groups

Номер: US20120175563A1
Автор: Axel Schmidt, Frank Kobelka, Jorg Hofmann, Klaus Lorenz, Mathias Matner, Michael Ludewig
Принадлежит: BAYER MATERIALSCIENCE AG

The present invention relates to reactive diluents for moisture-curing coating systems containing silane groups. The invention further relates to a method for the production of said diluents, and to the use thereof in coating agents, adhesives and sealants.

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Номер записи: 18
19-07-2012 дата публикации

Process for preparing a polymer polyol

Номер: US20120184707A1
Автор: Andre Buijs, Nico Maria Venne, Paulus Jacobus Fennis, Willem Karzijn
Принадлежит: Shell Internationale Research Maatschappij BV

The invention relates to a process for preparing a polymer polyol, comprising mixing in a reactor vessel, a base polyol, one or more ethylenically unsaturated monomers, a polymerization initiator, optionally a macromer, and optionally a chain transfer agent, and polymerizing the mixture thus obtained at a temperature of 50 to 200° C., wherein after discharging the reactor vessel content, the interior surface of the reactor vessel walls and/or any internals present in the reactor vessel are blasted with round media.

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Номер записи: 19
02-08-2012 дата публикации

Degradable heterobifunctional poly(ethylene glycol) acrylates and gels and conjugates derived therefrom

Номер: US20120195846A1
Автор: J. Milton Harris, Xuan Zhao
Принадлежит: Nektar Therapeutics AL Corp

A heterobifunctional poly(ethylene glycol) is provided having a hydrolytically degradable linkage, a first terminus comprising an acrylate group, and a second terminus comprising a target such as a protein or pharmaceutical agent or a reactive moiety capable of coupling to a target. Hydrogels can be prepared. The hydrogels can be used as a carrier for a protein or a pharmaceutical agent that can be readily released in a controlled fashion.

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Номер записи: 20
09-08-2012 дата публикации

Crosslinkable fluororubber composition and crosslinked rubber article

Номер: US20120202950A1
Автор: Daisuke Shirakawa, Kunio Watanabe, Makoto Honda, Tomoyuki Fujita
Принадлежит: Asahi Glass Co Ltd

Obtaining a crosslinked rubber with high flexibility at low temperature includes crosslinking a fluororubber composition. The fluororubber composition includes a fluororubber and a compound of formula (X—) x (Z—) z Y. In the formula, X is U—(CF 2 ) a O(CF 2 CF 2 O) b —; Z is R F O(CF 2 CF 2 O) c —; Y is a (x+z) valent perfluoro saturated hydrocarbon group, optionally interrupted by an etheric oxygen atom; x is an integer of at least 3; z is an integer of at least 0; U is a monovalent group with an unsaturated hydrocarbon, a bromine atom, an iodine atom, or a combination thereof; R F is a C 1-20 linear perfluoroalkyl group, optionally interrupted by an etheric oxygen atom; a is an integer of from 0 to 20; b is an integer of from 1 to 200; and c is an integer of from 3 to 200.

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Номер записи: 21
23-08-2012 дата публикации

Process for preparing a polyurethane foam

Номер: US20120214888A1
Автор: Christophe Martin Swan, Els Van Eetvelde, Michiel Barend Eleveld, Tiew Imm Tan, Waltherus Petrus Casparus Mineur
Принадлежит: Individual

The invention relates to a process for preparing a polyurethane foam, wherein a polyether polyol and a polyisocyanate are reacted in the presence of: a blowing agent; of from 1 to 30 ppmw, based on the polyether polyol, of metals derived from a composite metal cyanide complex catalyst; and of from 0.5 to 100 ppmw, based on the polyether polyol, of a phosphoric acid compound comprising a phosphoric acid selected from orthophosphoric acid, polyphosphoric acid and polymetaphosphoric acid, and/or a partial ester of such a phosphoric acid.

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Номер записи: 22
23-08-2012 дата публикации

Polymers based on glycerol carbonate and an amine

Номер: US20120215020A1
Автор: Fabien Jean Brand, Roman Benedikt Raether
Принадлежит: BASF SE

The present invention relates to a polymer and the associated polymerization process, and to the use of the polymers according to the invention for example as foam suppressant, for the dispersion of solids or as surfactant for washing or cleaning purposes. The polymer is prepared by polymerization of a) at least one alkylene oxide or a cyclic carbonate of the formula (I) where n is 1 to 10, m is 0 to 3 and R 1 is C 1 -C 10 -alkyl, C 2 -C 10 -alkenyl, aryl or aralkyl, b) glycerol carbonate and c) at least one amine.

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Номер записи: 23
06-09-2012 дата публикации

Branched poly(trimethylene ether) polyols

Номер: US20120225964A1
Автор: Gyorgyi Fenyvesi, Hari Babu Sunkara, Raja Hari Poladi
Принадлежит: EI Du Pont de Nemours and Co

Disclosed is branched poly(trimethylene ether)polyols prepared from the acid catalyzed polycondensation reaction of 1,3-propanediol, and at least one triol comonomer selected from 1,1,1-tris(hydroxymethyl)ethane and 1,1,1-tris(hydroxymethyl)propane. Also disclosed is a branched poly(trimethylene ether)polyol with an equivalent hydroxyl functionality of about 2.1 to about 3.2 and a M n of about 200 to about 6000. The polyols are useful in the preparation of polyurethane rigid and flexible foams.

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Номер записи: 24
20-09-2012 дата публикации

Amine adducts

Номер: US20120238710A1
Автор: Ludwig Huelskaemper, Marcus Hummel, Markus Schroetz
Принадлежит: Individual

Embodiments include an amine adduct obtainable by reacting an amine compound having at least two amino groups and a monoalkylpolyalkylene glycidyl ether having the formula (C 2 H 3 O)—CH 2 —O—(CH 2 —(CHR 1 )—O) n , —R 2 , wherein n is 1 to 50, each R 1 is independently H or CH 3 , and R 2 is an alkyl group. Embodiments include a curable composition including a resin component and a hardener component that includes the amine adduct.

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Номер записи: 25
27-09-2012 дата публикации

Defoamers for airless paint spray application

Номер: US20120240820A1
Автор: Armin TEMEL, Gerald Hobisch, Joachim Schmidt, Peter Morre, Thomas Schönbacher
Принадлежит: Cytec Austria GmbH

The invention relates to an ester AB of a polypropylene glycol A with fatty acids B, which ester AB can be added in the form of an aqueous emulsion to an aqueous coating composition, and a method of use of the ester AB as defoamer additive.

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Номер записи: 26
04-10-2012 дата публикации

Antimicrobial constructs

Номер: US20120251592A1
Автор: Jennifer A. Neff, Joseph Mcguire, Pranav R. Joshi
Принадлежит: ALLVIVO VASCULAR Inc, Oregon State University

The invention is based on the recognition that known antimicrobial compounds, such as nisin or other lantibiotics, can be made to form a long lasting antimicrobial surface coating by linking the peptide with a block polymer, such as PLURONIC® F108 or an end group activated polymer (EGAP) in a manner to form a flexible tether and/or entrap the peptide. The entrapped peptide provides antimicrobial action by early release from entrapment while the tethered peptide provides longer lasting antimicrobial protection. Antimicrobial gels and foams may be prepared using the antimicrobial peptide containing block copolymers.

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Номер записи: 27
04-10-2012 дата публикации

Moisture Curable Silylated Polymer Compositions With Improved Adhesion to Concrete

Номер: US20120251832A1
Автор: Jeries Nesheiwat, Misty Huang
Принадлежит: Momentive Performance Materials Inc

A moisture-curable resin composition comprising (a) at least one moisture-curable polymer having at least one hydrolysable silyl group; (b) at least one hydrocarbylalkoxysilane; and (c) at least one silane adhesion promoter containing a glycidoxy group. The composition may also contain additives including a catalyst for catalyzing the reaction between the moisture-curable polymer having at least one hydrolysable silyl group (a) with water under curing conditions, a filler, a plasticizer, and combinations thereof. The moisture-curable resin composition is useful in the production of adhesives, sealants and coatings for use in primerless concrete applications.

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Номер записи: 28
04-10-2012 дата публикации

Blends of polyarylene ethers and polyarylene sulfides

Номер: US20120252962A1
Автор: Christian Maletzko, Mark Völkel, Martin Weber, Norbert Güntherberg, Rüdiger Bluhm, Susanne Zeiher
Принадлежит: BASF SE

The present invention relates to thermoplastic molding materials comprising the following components: (A) at least one polyarylene ether, (B) at least one polyarylene sulfide, (C) at least one functionalized polyarylene ether comprising carboxyl groups having a viscosity number according to DIN EN ISO 1628-1 of 45 to 65 ml/g measured in 1% strength by weight solution in N-methyl-2-pyrrolidone at 25° C., (D) at least one fibrous or particulate filler and (E) optionally further additives and/or processing assistants. In addition, the present invention relates to a process for the preparation of the thermoplastic molding materials according to the invention, the use thereof for the production of shaped articles and the use of functionalized polyarylene ethers comprising carboxyl groups having a viscosity number according to DIN EN ISO 1628-1 of 45 to 65 ml/g measured in 1% strength by weight solution in N-methyl-2-pyrrolidone at 25° C. for increasing the elongation at break and for improving the impact strength.

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Номер записи: 29
04-10-2012 дата публикации

Conditioning of double metal cyanide catalysts

Номер: US20120253005A1
Автор: Achim Loeffler, Igor Shishkov, Ronald Adelmann, Sirus Zarbakhsh, Wolfgang Rohde
Принадлежит: BASF SE

The invention relates to a method for conditioning double metal catalysts which are used in the production of polyether polyols. The conditioning enhances the performance of the catalyst, so that lower concentrations of the DMC catalyst can be used in polyether polyol production.

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Номер записи: 30
01-11-2012 дата публикации

Method of separating a poly(arylene ether) composition from a solvent, and poly(arylene ether) composition prepared thereby

Номер: US20120277399A1
Автор: Alvaro Carrillo, Christina Louise Braidwood, Gerardo Rocha-Galicia, Hua Guo
Принадлежит: Alvaro Carrillo, Christina Louise Braidwood, Gerardo Rocha-Galicia, Hua Guo

A method of separating a poly(arylene ether) from a solvent includes treating a poly(arylene ether)-containing solution with a devolatilizing extruder to form an extruded composition, and cooling the extruded composition with a cooling device that does not immerse the extruded composition in water. The composition may be used to isolate a poly(arylene ether) from the solvent-containing reaction mixture in which it is prepared, or to remove solvent from a multi-component poly(arylene ether)-containing thermoplastic composition.

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Номер записи: 31
15-11-2012 дата публикации

Perfluoropolyether-containing compounds with oxalylamino groups

Номер: US20120289736A1
Автор: David S. Hays, George G.I. Moore, Miguel A. Guerra, Ramesh C. Kumar, Richard G. Hansen, Suresh S. Iyer, Yu Yang
Принадлежит: 3M Innovative Properties Co

Compounds containing at least one perfluoropolyether segment and at least two oxalylamino groups as well as methods of making these compounds are described. The compounds can be polymeric materials or can be used in the preparation of various copolymeric materials by reaction with compounds having at least two primary or secondary amino groups.

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Номер записи: 32
22-11-2012 дата публикации

Blends of polyarylene ethers and polyarylene sulfides

Номер: US20120296031A1
Автор: Christian Maletzko, Mark Völkel, Martin Weber, Norbert Güntherberg, Rüdiger Bluhm, Susanne Zeiher
Принадлежит: BASF SE

The present invention relates to thermoplastic molding materials comprising the following components: (A) at least one polyarylene ether, (B) at least one polyarylene sulfide, (C) optionally at least one functionalized polyarylene ether comprising carboxyl groups, (D) at least one fibrous or particulate filler and (E) optionally further additives and/or processing assistants, the ratio of the apparent viscosity of the component (A) to that of the component (B), determined at 350° C. and a shear rate of 1150 s −1 , being from 2.5 to 3.7.

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Номер записи: 33
29-11-2012 дата публикации

Simplified organic electronic device employing polymeric anode with high work function

Номер: US20120298974A1
Автор: Seong-Hoon Woo, Tae-woo Lee
Принадлежит: Academy Industry Foundation of POSTECH

An electronic device employing a polymeric anode with high work function.

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Номер записи: 34
29-11-2012 дата публикации

Intermediates useful in the preparation of maleimide functionalized polymers

Номер: US20120302761A1
Автор: Antoni Kozlowski, Brian Bray, Samuel P. McManus, Tracy L. Hutchison, Xiaoming Shen
Принадлежит: Nektar Therapeutics

Methods for forming maleimide functionalized polymers are provided. In one such embodiment, a maleimide functionalized polymer is prepared in a method that includes a step of carrying out a reverse Diels-Alder reaction. Intermediates useful in the methods, as well as methods for preparing the intermediates, are also provided. Also provided are polymeric reagents, methods of using polymeric reagents, compounds and conjugates.

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Номер записи: 35
06-12-2012 дата публикации

New polyglycerol esters and their use

Номер: US20120309667A1
Автор: Hans Henning Wenk, Peter Lersch, Ulrike Kottke
Принадлежит: EVONIK GOLDSCHMIDT GMBH

The present invention relates to polyglycerol partial esters of linear, unsubstituted carboxylic acids and bifunctional carboxylic acids with the provisos that the polyglycerol partial ester comprises an HLB-value from 2 to 10 and that the polyglycerol obtained by hydrolysis or alcoholysis of the polyglycerol partial ester comprises an average degree of polymerization of from 2 to 8 and at least 1% of the polyglycerol comprises cyclic structures. The present invention also relates to the preparation thereof and their use in fabric and textile care products.

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Номер записи: 36
20-12-2012 дата публикации

Polymeric reagents comprising a terminal vinylic group and conjugates formed therefrom

Номер: US20120318701A1
Автор: Samuel P. McManus, Sean M. Culbertson
Принадлежит: Nektar Therapeutics

The present invention provides conjugates having a degradable linkage and polymeric reagents useful in preparing such conjugates. Methods of making polymeric reagents and conjugates, as well as methods for administering conjugates and compositions, are also provided.

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Номер записи: 37
20-12-2012 дата публикации

Development of Novel Detergents for Use in PCR Systems

Номер: US20120322066A1
Автор: Jonathan Wang, Parul Angrish, Zhiwei Yang
Принадлежит: Life Technologies Corp

This disclosure relates to novel detergents for use in various procedures including, for example, nucleic acid amplification reactions such as polymerase chain reaction (PCR). Methods for preparing the modified detergents are also described.

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Номер записи: 38
20-12-2012 дата публикации

Branched polymers

Номер: US20120322134A1
Автор: Michael David Bentley, William Dudley Battle, Iii, Xiaoming Shen, Xuan Zhao
Принадлежит: Nektar Therapeutics

The present invention is directed to branched reactive water-soluble polymers comprising at least two polymer arms, such as poly(ethylene glycol), attached to a central aliphatic hydrocarbon core molecule through ether linkages. The branched polymers bear at least one functional group for reacting with a biologically active agent to form a biologically active conjugate. The functional group of the branched polymer can be directly attached to the aliphatic hydrocarbon core or via an intervening linkage, such as a heteroatom, -alkylene-, —O-alkylene-O—, -alkylene-O-alkylene-, -aryl-O—, —O-aryl-, (—O-alkylene-) m , or (-alkylene-O—) m linkage, wherein m is 1-10.

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Номер записи: 39
20-12-2012 дата публикации

Modified recombinant factor viii and von willebrand factor and methods of use

Номер: US20120322737A1
Автор: Hans-Peter Schwarz, Peter Turecek
Принадлежит: Baxter Healthcare SA, Baxter International Inc

The present invention provides novel methods of increasing the survival of a coagulation protein by inhibiting the interaction with a clearance receptor. The invention also provides methods of preparing compositions that inhibit coagulation protein clearance receptors. Conjugated coagulation proteins, including compositions and formulations thereof, are also provided by the present invention.

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Номер записи: 40
10-01-2013 дата публикации

Active energy ray-curable resin composition, and production method for products with surfaces of fine concave-convex structures

Номер: US20130011572A1
Автор: Eiko Okamoto, Satoru Ozawa, Tadashi Nakamura, Tetsuya Jigami, Yusuke Nakai
Принадлежит: Mitsubishi Rayon Co Ltd

The present invention relates to a production method for a product having a cured resin layer with a fine concave-convex structure formed on the surface of a substrate, the method including filling the space between a mold having a fine concave-convex structure composed of anodized alumina on the surface and a substrate with an active energy ray-curable resin composition, and curing the composition by irradiation with active energy rays, thereby forming a cured resin layer into which the fine concave-convex structure has been transferred on the surface of the substrate, wherein (A) the method includes treating the surface of the mold with a release agent, at least at transfer initiation, and (B) the active energy ray-curable resin composition includes a polymerizable compound, a polymerization initiator and a (poly)oxyethylene alkyl phosphate ester compound.

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Номер записи: 41
24-01-2013 дата публикации

Novel compounds

Номер: US20130022560A1
Автор: Alexander Schlifkeposchalko
Принадлежит: DSM IP ASSETS BV

The invention relates to novel polyglycerol based UV-filters as well as to topical compositions comprising such novel polyglycerol based UV-filters. Furthermore, the invention relates to the use of such novel polyglycerol based UV-filters to enhance the solubility of butyl methoxydibenzoylmethane or bis-ethylhexyloxyphenol methoxyphenyl triazine in cosmetic oils.

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Номер записи: 42
31-01-2013 дата публикации

Film, resin composition and polymer

Номер: US20130030116A1
Автор: Motoki Okaniwa, Takaaki Uno, Takashi Okada
Принадлежит: JSR Corp

Provided is a film comprising a polymer that comprises a structural unit represented by the following formula (1), wherein at least part of the terminal structure of the polymer is at least one structure selected from the group consisting of structural units represented by the following formula (2) and structural units represented by the following formula (3).

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Номер записи: 43
07-02-2013 дата публикации

Radical polymerizable resin, radical polymerizable resin composition, and cured product thereof

Номер: US20130035465A1
Автор: Kiyoharu Tsutsumi, Naoko Araki, Tomoaki Mahiko, Yoshinori Funaki
Принадлежит: Daicel Corp

Provided is a radically polymerizable resin which has a low viscosity, has excellent workability, and is rapidly cured upon application of heat and/or light to form a cured product having excellent flexibility and thermal stability. The radically polymerizable resin composition is obtained by cationic polymerization of an oxetane-ring-containing (meth)acrylic ester compound represented by following Formula (1) alone or in combination with another cationically polymerizable compound. In Formula (1), R 1 represents hydrogen atom or methyl group; R 2 represents hydrogen atom or an alkyl group; and “A” represents a linear or branched chain alkylene group having 4 to 20 carbon atoms.

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Номер записи: 44
14-02-2013 дата публикации

Methods for preparing polyethylene glycol maleimide using n-(2-hydroxyethyl) maleimide as a starting material

Номер: US20130041134A1
Автор: John R. Handley, Jonathon B. McKannan
Принадлежит: Sangart Inc

The present invention relates generally to methods for preparing polyethylene glycol maleimide (“PEG-Mal”). More specifically, the present invention relates to methods for synthesizing desired molecular weight PEG-Mal by direct ethoxylation of N-(2-hydroxyethyl)maleimide under specific reaction conditions.

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Номер записи: 45
14-03-2013 дата публикации

Coatings Containing Polymer Modified Enzyme For Stable Self-Cleaning Of Organic Stains

Номер: US20130065291A1
Автор: Andreas Buthe, Hongfei Jia, Liting Zhang, Masahiko Ishii, Minjuan Zhang, PING Wang, Songtao Wu, Xueyan Zhao
Принадлежит: Department of Bioproducts and Biosystems Engineering of University of Minnesota, Toyota Motor Corp, Toyota Motor Engineering and Manufacturing North America Inc

Bioactive coatings that are stabilized against inactivation by weathering are provided including a base associated with a chemically modified enzyme, and, optionally a first polyoxyethylene present in the base and independent of the enzyme. The coatings are optionally overlayered onto a substrate to form an active coating facilitating the removal of organic stains or organic material from food, insects, or the environment.

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Номер записи: 46
14-03-2013 дата публикации

Silicone Containing Compositions and Uses Thereof

Номер: US20130065998A1
Автор: Christine Anne Suzanne Louis, Kuo-Tsai Griffin Lai, Suresh Kalpatu Rajaraman
Принадлежит: Air Products and Chemicals Inc

Hydrogen, methyl, acetyl or butyl capped Polyether modified Silicone (PES) containing compositions are disclosed. The PES containing compositions can be used as defoamers or deaerators in coating compositions and, in particular, for airless sprayed compositions.

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Номер записи: 47
14-03-2013 дата публикации

Polymer compositions based on pxe

Номер: US20130066025A1
Автор: Hany Basam Eitouni, Jin Yang, Mohit Singh
Принадлежит: Seeo Inc

New polymer compositions based on poly(2,6-dimethyl-1,4-phenylene oxide) and other high-softening-temperature polymers are disclosed. These materials have a microphase domain structure that has an ionically-conductive phase and a phase with good mechanical strength and a high softening temperature. In one arrangement, the structural block has a softening temperature of about 210° C. These materials can be made with either homopolymers or with block copolymers.

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Номер записи: 48
21-03-2013 дата публикации

Aliphatic-aromatic copolyesters and their mixtures

Номер: US20130071588A1
Автор: Catia Bastioli, Giampietro Borsotti, Luigi Capuzzi, Roberto Vallero, Tiziana Milizia
Принадлежит: Novamont SpA

This invention relates to an aliphatic-aromatic copolyester characterised in that it has appreciable workability properties even when mixed with other polymers, appreciable toughness and high values for ultimate tensile strength and elastic modulus. This invention also relates to mixtures of the said copolyester with other polymers.

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Номер записи: 49
21-03-2013 дата публикации

ALCOHOL COMPOUND, A POLYESTER RESIN, AN UNSATURATED POLYESTER RESIN, A RESIN PARTICLE AND AN ELECTROPHOTOGRAPHIC TONER

Номер: US20130071785A1
Автор: Aihara Hiroshi, Moroiwa Tetsuji, Taniuchi Keiko, YAMANE Akira, Yamasaki Kei, Yoshida Nobutaka
Принадлежит: Japan U-Pica Company, Ltd.

It is an object of the present invention to provide a new alcohol compound, a polyester resin, an unsaturated polyester resin, a resin particle and an electrophotographic toner using the compound capable of using the renewable resources as a part of a raw material. 3. An unsaturated polyester resin wherein the compound according to claim 1 , is an essential component of an alcohol component.4. An unsaturated polyester resin wherein the compound according to is an essential component of an alcohol component and is contained at 20 percent by weight or more as a raw material of an unsaturated polyester.5. A premix molding compound comprising the unsaturated polyester resin according to .6. A premix molding compound according to claim 5 , wherein the compound is a sheet molding compound claim 5 , or a bulk molding compound.9. A polyester resin according to claim 5 , wherein the compound according to is contained at 20 percent by weight or more as a raw material of polyester.10. A resin composition for a powder coating comprising the polyester resin according to .11. A resin composition for an electrophotographic developer comprising the polyester resin according to .12. An urethane acrylate resin comprising the polyester resin according to that is modified by isocyanate.14. A resin particle according to claim 13 , wherein an average particle diameter of the resin particle is within a range from 0.01 to 1 μm.15. A resin particle according to claim 13 , wherein the resin particle is obtained by causing the phase inversion by means of adding a neutralizing agent and a water-based medium into a resin solution made by dissolving the polyester resin into an organic solvent claim 13 , and thereby forming an O/W emulsion of resin particle claim 13 , and further removing the organic solvent from a dispersion of an O/W emulsion of resin particle.17. A resin particle according to claim 13 , wherein the compound according to is contained at 20 percent by weight or more as a raw ...

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Номер записи: 50
21-03-2013 дата публикации

CURABLE FLUOROELASTOMER COMPOSITION

Номер: US20130072643A1
Автор: Bish Christopher J., MORKEN Peter A.
Принадлежит: E. I. DU PONT DE NEMOURS AND COMPANY

Fluoroelastomer compositions comprising fluoroelastomers having copolymerized units of a nitrile-containing cure site monomer are cured with certain carbazates. The carbazate is of the general formula ROC(O)NHNHR, wherein Ris 9-fluorenylmethyl, benzyl, aryl, or a heterocycle; Ris H, alkyl, aryl, heterocycle, CORor CHR; Ris alkyl, aryl, benzyl or a heterocycle; and Ris a fluoroalkyl group. 1. A curable composition comprising:A) a fluoroelastomer comprising copolymerized units of a nitrile group-containing cure site monomer; and{'sup': 1', '2', '1', '2', '3', '4', '3', '4, 'sub': 2', '2, 'B) a carbazate of the general formula ROC(O)NHNHR, wherein Ris 9-fluorenylmethyl, benzyl, aryl, or a heterocycle; Ris H, alkyl, aryl, heterocycle, CORor CHR; Ris alkyl, aryl, benzyl or a heterocycle; and Ris a fluoroalkyl group.'}2. A curable composition of wherein Ris H or COR.3. A curable composition of wherein said carbazate is selected from the group consisting of 9-fluorenylmethyl carbazate; diphenylmethyl carbazate; 1-(tert-butoxycarbonyl)-2-phenylhydrazine; phenyl carbazate; and benzyl carbazate.4. A curable composition of wherein said carbazate has at least one oxygen atom replaced by a sulfur atom.5. A curable composition of further comprising a curative accelerator.6. A cured article made from the composition of .7. A cured article of having a volume swell claim 6 , measured according to ASTM D1414 claim 6 , after exposure to 225° C. water for at least 168 hours of less than 5% and a compression set claim 6 , 300° C. claim 6 , 70 hours claim 6 , 15% compression claim 6 , measured according to ASTM D395 of less than 70%. This application claims the benefit of U.S. Provisional Application No. 61/469,856 filed Mar. 31, 2011.This invention relates to curable fluoroelastomer compositions and more particularly to fluoroelastomer compositions containing certain carbazates as curing agents.Fluoroelastomers have achieved outstanding commercial success and are used in a wide variety ...

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Номер записи: 51
21-03-2013 дата публикации

CURABLE FLUOROELASTOMER COMPOSITION

Номер: US20130072656A1
Автор: Bish Christopher J., MORKEN Peter A., Wheland Robert Clayton
Принадлежит: E. I. DU PONT DE NEMOURS AND COMPANY

Fluoroelastomer compositions comprising fluoroelastomers having copolymerized units of a nitrile-containing cure site monomer are cured with certain hydrazide curatives. The hydrazide is of the general formula R(C(O))NHNHR, wherein n is 1 or 2; Ris NH, NHNH, NHR, NR, NHNHC(O)NH, NHNHC(O)NHNH, NHNHR, or NHC(O)NHNH; Ris H, alkyl, aryl, heterocycle, COR, C(O)R, CHR, or C(O)R; Ris alkyl, aryl, heterocycle, or CHR; and Ris a fluoroalkyl group. 1. A curable composition comprising:A) a fluoroelastomer comprising copolymerized units of a nitrile group-containing cure site monomer; and{'sup': 1', '2', '1', '3', '3', '2', '2', '3', '3', '4', '4', '3', '4', '4, 'sub': n', '2', '2', '2', '2', '2', '2', '2', '2', '2, 'B) a hydrazide of the general formula R(C(O))NHNHR, wherein n is 1 or 2; Ris NH, NHNH, NHR, NR, NHNHC(O)NH, NHNHC(O)NHNH, NHNHR, or NHC(O)NHNH; Ris H, alkyl, aryl, heterocycle, COR, C(O)R, CHRor C(O)R; Ris alkyl, aryl, heterocycle, or CHR; and Ris a fluoroalkyl group.'}2. A curable composition of wherein n is 1; Ris NH claim 1 , NHNH claim 1 , NHR claim 1 , NR claim 1 , NHNHC(O)NH claim 1 , NHNHC(O)NHNH claim 1 , NHNHR claim 1 , or NHC(O)NHNH; and Ris H.3. A curable composition of wherein n is 2; Ris NH claim 1 , NHNH claim 1 , NHR claim 1 , NR claim 1 , NHNHC(O)NH claim 1 , NHNHC(O)NHNH claim 1 , NHNHR claim 1 , or NHC(O)NHNH; and Ris H.4. A curable composition of wherein n is 1; Ris NH claim 1 , NHNH claim 1 , NHR claim 1 , NR claim 1 , NHNHC(O)NH claim 1 , NHNHC(O)NHNH claim 1 , NHNHR claim 1 , or NHC(O)NHNH; and Ris COR.5. A curable composition of wherein n is 2; Ris NH claim 1 , NHNH claim 1 , NHR claim 1 , NR claim 1 , NHNHC(O)NH claim 1 , NHNHC(O)NHNH claim 1 , NHNHR claim 1 , or NHC(O)NHNH; and Ris COR.6. A curable composition of wherein said hydrazide is selected from the group consisting of carbohydrazide; carbonic dihydrazide claim 1 , dihydrochloride; 4-phenylsemicarbazide; 4-phenylsemicarbazide hydrochloride; 4 claim 1 ,4-diphenylsemicarbazide; oxamic ...

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Номер записи: 52
21-03-2013 дата публикации

MEMBRANE ENHANCED POLYMER SYNTHESIS

Номер: US20130072691A1
Автор: Campos Vasconcelos Renato, Gaffney Piers Robert James, Livingston Andrew Guy
Принадлежит: IMPERIAL INNOVATIONS LIMITED

This invention relates to the synthesis of polymers. More specifically, the present invention relates to the synthesis of heterobifunctional polymers and polymers with narrow and mono-disperse molecular weight distributions, and especially to the application of membranes to the synthesis of these polymers. 1. A process for the preparation of heterobifunctional or mono-disperse polymers comprising the following steps:(a) reacting an excess of an initial polymer dissolved in a solvent with a branch point molecule to form a polymer mixture containing at least the initial polymer and a conjugate comprising at least two polymer molecules covalently bound to the branch point molecule such that each polymer molecule has a terminal which is bound to the branch point molecule and at least one unbound terminal;(b) contacting the polymer mixture with a semi-permeable membrane which has a rejection for the conjugate which is greater than the rejection for the initial polymer, so that the ratio between the concentrations of the conjugate and the initial polymer in the retentate is increased; and(c) cleaving the polymer from the branch point molecule of the conjugate;wherein the at least one unbound terminal of the polymer molecule of the conjugate is chemically modified to either modify the functionality of the unbound terminal of the polymer or add additional monomer or polymer units to the polymer and said modification occurs either prior to or subsequent to step (b) such that the polymer cleaved from branch point molecule comprises the initial polymer comprising at least one chemically modified terminal.2. A process as in claim 1 , wherein the process is a process for the preparation of heterobifunctional polymers and said chemical modification involves the removal of any protecting groups that may be present at the unbound terminal of the polymer followed by the functionalisation of the unbound terminal.3. A process according to claim 1 , wherein the process is a process for ...

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Номер записи: 53
28-03-2013 дата публикации

ISOSELECTIVE POLYMERIZATION OF EPOXIDES

Номер: US20130079491A1
Автор: Coates Geoffrey W., HIRAHATA Wataru
Принадлежит: CORNELL UNIVERSITY

The present invention provides novel bimetallic complexes and methods of using the same in the isoselective polymerization of epoxides. The invention also provides methods of kinetic resolution of epoxides. The invention further provides polyethers with high enantiomeric excess that are useful in applications ranging from consumer goods to materials. 2. The bimetallic complex of claim 1 , wherein the complex contains an element having axial chirality.9. The bimetallic complex of claim 8 , wherein M is selected from the group consisting of a transition metal from group 5-12 claim 8 , inclusive claim 8 , boron and aluminum.10. The bimetallic complex of claim 9 , wherein M is selected from the group consisting of Cr claim 9 , Mn claim 9 , V claim 9 , Fe claim 9 , Co claim 9 , Mo claim 9 , W claim 9 , Ru claim 9 , Ti claim 9 , Al claim 9 , Zr claim 9 , Hf claim 9 , and Ni.11. The bimetallic complex of claim 10 , wherein M is Co.12. The bimetallic complex of claim 8 , wherein Q is optionally substituted Caliphatic.13. The bimetallic complex of claim 8 , wherein Q is optionally substituted 1 claim 8 ,2-cyclohexyl.14. The bimetallic complex of claim 13 , wherein Q is (R claim 13 ,R)-1 claim 13 ,2-cyclohexyl when the bond between the biaryl linkage is of S chirality.15. The bimetallic complex of claim 13 , wherein Q is (S claim 13 ,S)-1 claim 13 ,2-cyclohexyl when the bond between the biaryl linkage is of R chirality.16. The bimetallic complex of claim 8 , wherein Rand Rare taken together with their intervening atoms to form a 6-membered aryl ring.19. The bimetallic complex of claim 8 , wherein each of R claim 8 , R claim 8 , R claim 8 , R claim 8 , and Ris hydrogen.20. The bimetallic complex of claim 8 , wherein each of R claim 8 , R claim 8 , R claim 8 , R claim 8 , R claim 8 , R claim 8 , and Ris hydrogen.21. The bimetallic complex of claim 8 , wherein one or more of R claim 8 , R claim 8 , R claim 8 , R claim 8 , R claim 8 , R claim 8 , and Ris substituted with an ...

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Номер записи: 54
28-03-2013 дата публикации

Method for Preparing a Polymer Conjugate

Номер: US20130079533A1
Автор: Zhang Wen
Принадлежит: Nektar Therapeutics

Provided herein is a straightforward and efficient method for covalently attaching a polyethylene glycol polymer to a taxane. The method involves, among other things, a step of reacting a taxame with a polyethylene glycol polymer comprising a functional group reactive with a functional group within said taxane in the presence of a coupling reagent and DPTS. The result of the reacting step is the formation of a polyethylene glycol-taxane conjugate. 2. The method of claim 1 , wherein said coupling reagent is a carbodiimide.3. The method of claim 2 , wherein said coupling reagent is selected from the group consisting of dicyclohexylcarbodiimide (DCC) claim 2 , N claim 2 ,N′-diisopropylcarbodiimide (DIC) claim 2 , 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDAC) claim 2 , 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) claim 2 , N-tert-butyl-N′-methylcarbodiimide (TBMC) claim 2 , and N-tert-butyl-N′-ethylcarbodiimide (TBEC).4. The method of claim 1 , wherein said coupling reagent is N claim 1 ,N′-diisopropylcarbodiimide.54. The method of any one of to claim 1 , wherein said reacting step is carried out in an organic solvent selected from the group consisting of dichloromethane claim 1 , chloroform claim 1 , acetonitrile and tetrahydrofuran.6. The method of claim 5 , wherein said reacting step is carried out at a temperature ranging from 0° C. to 100° C.7. The method of claim 6 , wherein said reacting step is carried out at room temperature.84. The method of any one of - claim 1 , wherein the amount of DPTS in said reacting step ranges from about 0.05 to 0.75 equivalents relative to said functional group within said taxane.9. The method of claim 8 , wherein the amount of DPTS in said reacting step ranges from about 0.10 to 0.60 equivalents relative to said functional group within said taxane.104. The method of any one of - claim 1 , wherein the amount of said coupling reagent ranges from about 1.25 to 5 equivalents relative to said functional group ...

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Номер записи: 55
28-03-2013 дата публикации

Polymeric Surfactant

Номер: US20130079536A1
Автор: Chandler John Mark, Chen Xin
Принадлежит: CRODA, INC.

A compound of the formula 1. A compound of the formula (I):{'br': None, 'sup': 1', '2, 'sub': n', 'm, 'R.[(AO).-A-OR]\u2003\u2003(I)'}where:{'sup': '1', 'Ris the residue of a group having at least m active hydrogen atoms where m is at least 2;'}AO is an alkylene oxide residue;each n is independently from 0 to 100; and{'sup': 2', '3', '3', '2, 'each Ris independently H or an acyl group CORwhere each Ris independently a residue of a polyhydroxyalkyl or polyhydroxyalkenyl carboxylic acid, a residue of a hydroxyalkyl or hydroxyalkenyl carboxylic acid and/or a residue of an oligomer of the hydroxyalkyl or hydroxyalkenyl carboxylic acid wherein on average at least 2 of Ris an acyl group.'}2. A compound according to wherein Ris the residue of a group having at least 3 free hydroxyl and/or amino groups.3. A compound according to claim 1 , wherein Ris the residue of a sugar claim 1 , preferably a monosaccharide.4. A compound according to having a molecular weight of from 3000 to 8000.5. A compound according to having an HLB from 1.3 to 15.6. Use of the compound according to as a water in oil emulsifier claim 1 , wetting agent claim 1 , oil in water emulsifier claim 1 , detergent claim 1 , dispersant and/or solubiliser.7. A process for the manufacture of compound (I) which process involves reacting the group Rwith alkylene oxide and then esterifying the alkoxylated product of this reaction with a polyhydroxyalkyl (alkenyl) carboxylic acid and/or hydroxyalkyl (alkenyl) carboxylic acid.8. A process as claimed in wherein the molar ratio of alkoxylated product to polyhydroxyalkyl (alkenyl) carboxylic acid and/or hydroxyalkyl (alkenyl) carboxylic acid ranges from 1:2 to 1:40. This application claims the benefit of priority from U.S. Provisional Application No. 61/282,689, filed Mar. 17, 2010. The foregoing related application, in its entirety, is hereby incorporated by reference.This invention relates to new liquid polymeric surfactants derived from star shaped polymers and their ...

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Номер записи: 56
04-04-2013 дата публикации

Polyoxymethylene Compositions For Producing Containment Devices

Номер: US20130082064A1
Автор: Lowell Larson, Malvika BIHARI, Ursula Ziegler
Принадлежит: Ticona LLC

Polyoxymethylene polymer compositions are disclosed that contain an impact modifier. In accordance with the present disclosure, the impact modifier is attached to the polyoxymethylene polymer and comprises a thermoplastic elastomer containing carbonate groups, such as polycarbonate groups. In one embodiment, a coupling agent bonds the impact modifier to the polyoxymethylene polymer. Incorporation of an impact modifier containing carbonate groups has been found to produce articles having good impact resistance properties while also preserving the permeability of the material. The polymer composition is well suited to producing containment devices, especially fuel tanks.

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Номер записи: 57
18-04-2013 дата публикации

Reagents and methods for phosphorylation/dephosphorylation analyses

Номер: US20130095502A1
Автор: Anton B. Iliuk, Weiguo A. Tao
Принадлежит: PURDUE RESEARCH FOUNDATION

Disclosed herein are reagents that include a moiety that includes a metal such as titanium and that readily binds to phosphorylated molecules the reagents also include at least one moiety that produces a signal or that binds to a molecule that produces a signal. The reagent may also include a moiety that binds to a larger molecule or to a surface. Some forms of the reagent include a dendrimer that can simultaneously bind to multiple metal moieties that include a metal such as titanium and multiple moieties that can be used to detected bound molecules. These reagents can be used in detection and/or measurement and/or at least partial purification of phosphorylated molecules. These reagents and methods using them are used to analyze proteins, polypeptides, nucleic acids, phospholipids and the like. They are readily adapted for use in gels, blots, plate based high through put assays and for mass spectrometry.

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Номер записи: 58
18-04-2013 дата публикации

siRNA conjugate and preparation method thereof

Номер: US20130096288A1
Автор: Han Bo Ram, Lee Sam Young, Park Han Oh, Shin Mi Sik
Принадлежит: BIONEER CORPORATION

Provided are an siRNA-polymer conjugate, and a method for preparing the same, and more specifically, to a hybrid conjugate formed by covalently bonding siRNA and a polymeric compound for improving the in vivo stability of siRNA, and to a preparation method of the hybrid conjugate. The conjugate of the present invention can improve the in vivo stability of siRNA, thereby achieving an efficient delivery of therapeutic siRNA into cells and exhibiting the activity of siRNA even with a small dose of a relative low concentration. Therefore, the conjugate can advantageously be used as not only an siRNA treatment tool for cancers and other infectious disease, but also a novel type siRNA delivery system. 1. A conjugate of survivin-specific siRNA and polymer compound , of the structure below:{'br': None, 'A-X—R—Y—B'}(where, one of A and B is a hydrophilic polymer compound and the other thereof is a hydrophobic polymer compound; X and Y each are independently a simple covalent bond or a linker-mediated covalent bond; and R is a survivin-specific siRNA.)2. The conjugate of claim 1 , wherein a single strand of the survivin-specific siRNA (R) is composed of 19 to 31 nucleotides.3. The conjugate of claim 1 , wherein the survivin-specific siRNA (R) is any one selected from nucleotide sequences of SEQ ID NOs.: 1 to 4.4. The conjugate of claim 1 , wherein the survivin-specific siRNA(R) has chemical modification.5. The conjugate of claim 4 , wherein the chemical modification includes at least one selected from:modifying a phosphorodiester bond into a phosphorothioate linkage;{'sub': '3', 'modifying —OH at the 2′-position of a pentose into 2′-OCHor 2′-dioxy-2′-fluouridine; and'}modifying —OH at the 2′ position of the pentose into an LNA type formed by linking the 2′ position and the 4′ position of the pentose.6. The conjugate of claim 1 , wherein the hydrophobic polymer compound has a molecular weight of 250 to 1 claim 1 ,000; the hydrophilic polymer compound is a non-ionic polymer ...

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Номер записи: 59
25-04-2013 дата публикации

Protein-Polymer-Drug Conjugates

Номер: US20130101546A1
Автор: Bodyak Natalya D., Conlon Patrick R., Gumerov Dmitry R., Hammond Charles E., Lowinger Timothy B., Stevenson Cheri A., Thomas Joshua D., Yin Mao, Yurkovetskiy Aleksandr V.
Принадлежит: MERSANA THERAPEUTICS, INC.

A drug conjugate is provided herein. The conjugate comprises a protein based recognition-molecule (PBRM) and a polymeric carrier substituted with one or more -L-D, the protein based recognition-molecule being connected to the polymeric carrier by L. Each occurrence of D is independently a therapeutic agent having a molecular weight≦5 kDa. Land Lare linkers connecting the therapeutic agent and PBRM to the polymeric carrier respectively. Also disclosed are polymeric scaffolds useful for conjugating with a PBRM to form a polymer-drug-PBRM conjugate described herein, compositions comprising the conjugates, methods of their preparation, and methods of treating various disorders with the conjugates or their compositions. 2. The scaffold of claim 1 , wherein the PHF has a molecular weight ranging from 30 kDa to 100 kDa claim 1 , mis an integer from 3 to about 100 claim 1 , mis an integer from 1 to 40 claim 1 , and mis an integer from 1 to 220.3. The scaffold of claim 1 , wherein the functional group of Lis selected from —SR claim 1 , —S—S-LG claim 1 , maleimido claim 1 , and halo claim 1 , in which LG is a leaving group and Ris H or a sulfur protecting group.5. The scaffold of claim 1 , wherein Lcontains a biodegradable bond.6. The scaffold of claim 1 , further comprising a PBRM connected to the polymeric carrier via L.8. The scaffold of claim 7 , wherein the PHF has a molecular weight ranging from 30 kDa to 100 kDa claim 7 , mis an integer from 1 to 220 claim 7 , mis an integer from 3 to 100 claim 7 , mis an integer from 0 to 40 claim 7 , and mis an integer from 1 to 20 claim 7 , and the sum of mand mis an integer from 18 to 220 claim 7 , and the sum of mand mis an integer from 1 to 40.9. The scaffold of claim 7 , wherein mis an integer from 3 to about 150 and the sum of mand mis an integer from 14 to 330.10. The scaffold of claim 7 , wherein mis an integer from 1 to about 10.11. The scaffold of claim 7 , wherein each occurrence of PBRM independently has a molecular ...

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Номер записи: 60
25-04-2013 дата публикации

THERMOSETTING RESIN COMPOSITION, CURED PRODUCT THEREOF, ACTIVE ESTER RESIN, SEMICONDUCTOR ENCAPSULATING MATERIAL, PREPREG, CIRCUIT BOARD, AND BUILD-UP FILM

Номер: US20130101857A1
Автор: Arita Kazuo, Suzuki Etsuko
Принадлежит: DIC CORPORATION

A thermosetting resin composition contains an active ester resin (A) and an epoxy resin (B) as essential components, the active ester resin (A) having a resin structure which includes a polyaryleneoxy structure (I) and in which aromatic carbon atoms in a plurality of the polyaryleneoxy structures (I) are linked through a structural site (II) represented by a structural formula 1 (wherein Ar represents a phenylene group, a phenylene group nuclear-substituted by 1 to 3 alkyl groups each having 1 to 4 carbon atoms, a naphthylene group, or a naphthylene group nuclear-substituted by 1 to 3 alkyl groups each having 1 to 4 carbon atoms). 118-. (canceled)22. The thermosetting resin composition according to , or , wherein the active ester resin (A) contains , in its resin structure , arylcarbonyloxy groups with a functional group equivalent in a range of 220 to 350 g/eq. in terms of monofunctional group equivalent.23. A cured product produced by curing the epoxy resin composition according to , or .27. A semiconductor encapsulating material comprising a thermosetting resin composition further containing an inorganic filler (C) at a ratio of 70 to 95% by mass in the composition in addition to the active ester resin (A) and the epoxy resin (B) of the epoxy resin composition according to , or .28. A prepreg produced by impregnating a reinforcement substrate with the thermosetting resin composition according to , or , which is diluted with an organic solvent , and then semi-curing the resultant impregnated substrate.29. A circuit board produced by diluting the thermosetting resin composition according to , or with an organic solvent to prepare a varnish , shaping the varnish into a plate , and molding the plate and a copper foil under heating and pressure.30. A build-up film produced by applying the thermosetting resin composition according to , or , which is diluted with an organic solvent , to a base film and then drying the film. The present invention relates to a ...

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Номер записи: 61
25-04-2013 дата публикации

ADDUCTS WITH PERFLUOROPOLYETHER PHOSPHATE AND USES THEREOF

Номер: US20130102712A1
Автор: Baroni Sergio, Benedusi Anna, Giuliani Giammaria, Mascolo Antonio, Pantini Giovanni
Принадлежит: GIULIANI S.P.A.

The present invention relates, in one aspect, to an adduct of formula O-PF-A, in which O is an oil; PF is a perfluoropolyether phosphate (PFPE phosphate); A is at least one substance selected from: (X) a water-soluble polyhydroxylated substance and (Y) a water-insoluble inorganic substance and to topical applications thereof in particular in the cosmetic and pharmaceutical field. 2. Adduct according to claim 1 , wherein the perfluoropolyether phosphate (PF) has the formula:{'br': None, 'sub': 2', '2', '2', 'n', '2', 'f', '2', '2', '2', 'n', '2, '(HO)OP—O—(CHCHO)—CH—R—CH—(OCHCH)—O—P—O(OH)'}and wherein{'sub': f', '2', '2', 'p', '2', 'q, 'claim-text': [{'sub': 2', '2', '2, 'with random distribution of —CFCFO— and —CFO— units,'}, 'with p/q=0.5-3.0', 'n=1-2, 'R=—(CFCFO)—(CFO)represents a (per)fluoropolyether chain{'sub': 'f', 'and the average molecular weight of Ris from 500 to 4000.'}3. Adduct according to claim 1 , wherein it is in semisolid form.4. Adduct according to claim 1 , wherein the oil is selected from emollient oils claim 1 , UV sun filters claim 1 , fragrances claim 1 , cosmetic and pharmaceutical active ingredients in the form of oils claim 1 , and mixtures thereof.5. Adduct according to claim 1 , wherein said water-soluble polyhydroxylated substance or compound (X) comprises at least one carboxyl group and the water-insoluble inorganic substance or compound (Y) is in the form of micronized powder.6. Adduct according to claim 1 , wherein said polyhydroxylated substance or compound (X) is selected from lactates claim 1 , citrates claim 1 , ascorbates and mixtures thereof.7. Adduct according to claim 6 , wherein said ascorbates are sodium ascorbate or ascorbic acid and mixtures thereof.8. Adduct according to claim 1 , wherein said water-insoluble inorganic substance or compound (Y) is selected from metal oxides claim 1 , phosphate minerals claim 1 , silicate minerals and mixtures thereof.9. A cosmetic treatment of skin comprising:{'claim-ref': {'@idref': 'CLM ...

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Номер записи: 62
25-04-2013 дата публикации

SULFONATED POLY(ARYLENE ETHER) COPOLYMER HAVING A CROSS-LINKABLE STRUCTURE, AND POLYELECTROLYTE MEMBRANE COMPRISING SAME

Номер: US20130102740A1
Автор: KIM Da Young, Kim Young Jea, KO Un, LEE Jae-Suk, Son Hyo Kyeong
Принадлежит: GWANGJU INSTITUTE OF SCIENCE AND TECHNOLOGY

Provided are a sulfonated poly(arylene ether) copolymer including a crosslinking structure and a polyelectrolyte membrane including the same. Particularly, a sulfonated poly(arylene ether) copolymer including a crosslinking structure in a polymer chain or at the terminal portion of the polymer chain, and a polyelectrolyte membrane including the same are provided. The polyelectrolyte membrane using the sulfonated poly(arylene ether) copolymer including the crosslinking structure, may have the same or better degree of a thermal stability, a mechanical stability, a chemical stability, a membrane forming capability, etc. than a commonly used polyelectrolyte membrane. In addition, the proton conductivity and the cell performance of the polyelectrolyte membrane may be remarkably improved than those of the commonly used polymer electrolyte. Further, the properties of the electrolyte membrane may be rarely changed, and a high measuring stability may be obtainable. The polyelectrolyte membrane may be used in a fuel cell or a secondary battery. 117-. (canceled)29. The method of manufacturing a sulfonated poly(Arlene ether) copolymer of claim 26 , wherein the condensation polymerizing is conducted by using a base claim 26 , an azeotropic solvent claim 26 , and an aprotic polar solvent or a protic polar solvent at a temperature of 10° C. to 300° C.30. The method of manufacturing a sulfonated poly(Arlene ether) copolymer of claim 27 , wherein the condensation polymerizing is conducted by using a base claim 27 , an azeotropic solvent claim 27 , and an aprotic polar solvent or a protic polar solvent at a temperature of 10° C. to 300° C.31. The method of manufacturing a sulfonated poly(Arlene ether) copolymer of claim 29 , wherein the aprotic solvent includes at least one selected from the group consisting of N-methylpyrrolidone (NMP) claim 29 , dimethyl formamide (DMF) claim 29 , N claim 29 ,N-dimethyl acetamide (DMAc) and dimethyl sulfoxide (DMSO) claim 29 , the protic solvent ...

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Номер записи: 63
02-05-2013 дата публикации

Plasticizers for Adhesive, Coating and Sealant Compositions Applied to Asphalt

Номер: US20130108882A1
Автор: Jonathan T. Stuart, William J. Werts
Принадлежит: Henry Co LLC

An asphalt-containing substrate having an adhesive, coating or sealant composition applied to the substrate surface and adhesive, coating or sealant compositions are described herein. The composition resists softening of the asphalt compound in the asphalt-containing substrate at elevated temperatures and includes at least one base material and at least one plasticizer. The plasticizer has is a low molecular weight compound and preferably includes an ester-containing reaction product of at least one glycerol and at least one carboxylic acid or a glycol and an aryl carboxylic acid. The composition base material is preferably a polymer or copolymer that includes polyurethanes, silylated polyurethanes, silylated polyethers, copolymers thereof, and blends thereof. Products containing the composition and a method of applying the composition to a substrate are also disclosed herein.

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Номер записи: 64
09-05-2013 дата публикации

In-vivo gelling pharmaceutical pre-formulation

Номер: US20130116341A1
Автор: George Horng, Syed H. Askari
Принадлежит: Medicus Biosciences LLC

Provided herein are in vivo gelling pharmaceutical pre-formulations forming biocompatible hydrogel polymers that are polymerized in vivo and kits comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally at least one therapeutic agent. The biocompatible hydrogel polymer is bioabsorbable and releases the therapeutic agent at a target site, avoiding systemic exposure.

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Номер записи: 65
09-05-2013 дата публикации

Method to produce copolymers of tetrahydrofuran and epoxidised natural oils

Номер: US20130116402A1
Автор: Hoong Seng Soi
Принадлежит: Palm Oil Research and Development Board

The invention relates to a method to produce polytetrahydrofuran (PTHF) copolymer from plant oil by copolymerizing epoxidized oil; preferably from natural sources like animal oils and more preferably from plants oils; with tetrahydrofuran (THF), in the presence of boron trifluoride-diethylether complex or tetrafluoroboric acid to yield the desired copolymer with specific properties. The properties of the produced PTHF copolymer depends on the (i) type of epoxidized oil used as co-monomer (ii) mole ratio between epoxidized oil and THF (iii) amount of catalyst (iv) reaction temperature (v) reaction time. The produced PTHF copolymers were then used as raw material for the production of polyurethane and polyurea.

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Номер записи: 66
09-05-2013 дата публикации

MODIFIED MACROMOLECULE

Номер: US20130116432A1
Автор: Boyd Benjamin James, Kaminskas Lisa Michelle, Karellas Peter, Kelly Brian Devlin, Krippner Guy Yeoman, Pallich Sue, Porter Christopher John Hamilton, Razzino Pasquale, Wu Zemin
Принадлежит: STARPHARMA PTY LTD

The present invention relates to a macromolecule having a controlled terminal group stoichiometry, the macromolecule including a surface layer, at least one subsurface layer and at least two terminal groups including: a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefor; and a second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule, wherein terminal group stoichiometry refers to the number and type of terminal groups. 1. A macromolecule having controlled terminal group stoichiometry and including at least one lysine or lysine analogue dendritic motif having a surface layer and at least one subsurface layer , the macromolecule including at least two terminal groups including:a first terminal group which is a residue of a pharmaceutically active agent, a derivative thereof or precursor therefore, anda second terminal group selected to modify the pharmacokinetics of the pharmaceutically active agent and/or macromolecule,wherein terminal group stoichiometry refers to the number and type of terminal groups.2. The macromolecule according to claim 1 , wherein the lysine or lysine dendritic motif or the macromolecule further exhibits controlled topology claim 1 , wherein topology describes the relationship between one terminal group and another in terms of its connection to the surface or subsurface layers of the macromolecule.3. The macromolecule according to claim 1 , wherein the second terminal group is polyethylene glycol (PEG) or polyethyloxazoline.4. The macromolecule according to claim 1 , wherein the second terminal group is a residue of folate or a folate derivative.5. The macromolecule according to claim 1 , wherein the pharmaceutically active agent is selected from the group consisting of: methotrexate; taxol; indomethacin; zenical; and cyclosporine.6. The macromolecule according to claim 1 , wherein the second terminal group is ...

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Номер записи: 67
09-05-2013 дата публикации

Branched polyethylene glycol linked with diacyl glycerol, process for producing the same, and polyethylene glycol modified liposome

Номер: US20130116461A1
Автор: Fumiaki Manabe, Yuji Yamamoto
Принадлежит: NOF Corp

Provided is a polyethylene glycol derivative which contains two PEG chains, which is bound to a diacylglycerol, which has high purity, and which enhances the stability of liposomes. Polyethylene glycol is represented by the following formula (1) and which is bound to a diacylglycerol: In Formula (1), R 1 is a hydrocarbon group containing 1 to 7 carbon atoms, R 2 is an alkyl or alkenyl group containing 9 to 21 carbon atoms, n is the average number of moles of added polyethylene glycol chains, 10 n 100, and X is a linker site between branched polyethylene glycol and the diacylglycerol and is represented by the following formula (2): In Formula (2), Y is an ether bond, an ester bond, a urethane bond, an amide bond, or a carbonate bond and 1 and m are an integer of 0 to 6.

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Номер записи: 68
16-05-2013 дата публикации

Derivatized Hyperbranched Polyglycerols

Номер: US20130122112A1
Автор: BROOKS Donald, Burt Helen M., Gleave Martin E., Guan Dechi, Jackson John K., Kainthan Rajesh Kumar, KIZHAKKEDATHU Jayachandran, Liggins Richard, Mugabe Clement, So Alan, YE Lu
Принадлежит:

Herein are provided derivatized hyperbranched polyglycerols (“dHPGs”). The dHPG comprises a core comprising a hyperbranched polyglycerol derivatized with CCalkyl chains and a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one hydrophilic substituent. The dHPGs are for use as agents for the delivery of a drug or other biologically active moiety to the urinary tract, the digestive tract, the airways, the vaginal cavity and cervix and the peritoneal cavity to treat indications such as cancer, which may be useful in the treatment of or the manufacture of a medicament, in the preparation, of a pharmaceutical composition for the treatment of cancer, as a pre-treatment or co-treatment to improve drug uptake in a tissue. Furthermore, there are provided methods of making dHPGs. 1. A hyperbranched polyglycerol , comprising:{'sub': 1', '20, 'a core comprising hyperbranched polyglycerol derivatized with C-Calkyl chains; and'}{'sub': 2', '2', '3', '3', '1', '6', '1', '6', '3', '12', '3, 'sup': +', '+', '+, "a shell comprising at least one hydrophilic substituent bound to hydroxyl groups of the core, wherein the at least one hydrophilic substituent comprises at least one functional group selected from one or more of the following: —NH, ═NH, —NH, and —NR, wherein each R is independently a C-Calkyl group or one R is independently a C-Calkyl group and two R's together form a C-Ccyclic alkyl group so that Rforms a quaternary amine with the nitrogen, and"}wherein the hyperbranched polyglycerol comprises from about 1 to about 200 moles of the at least one functional group per mole of the hyperbranched polyglycerol.2. The hyperbranched polyglycerol of claim 1 , wherein the at least one functional group is —NH.3. The hyperbranched polyglycerol of claim 1 , wherein the at least one hydrophilic substituent is methoxy polyethylene glycol (MePEG) claim ...

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Номер записи: 69
16-05-2013 дата публикации

ALLERGEN REDUCING AGENT, AND PROCESSED PRODUCT, COATING MATERIAL, AND WOOD BUILDING MATERIAL USING SAME

Номер: US20130122319A1
Автор: Fukuzawa Shigeharu, Nakamoto Shoichi, Omura Hiroyuki, Rokushima Kazumasa, Sakamoto Kenji
Принадлежит: Panasonic Corporation

An allergen reducing agent is provided that contains a terpenoid polymer or copolymer as an active component, and that functions to reduce allergens such as mites and pollen, and is capable of suppressing coloring. 1. An allergen reducing agent that comprises a terpenoid polymer or copolymer as an active component.2. The allergen reducing agent according to claim 1 , wherein the terpenoid copolymer is a copolymer of terpenoid and an aromatic monomer.3. The allergen reducing agent according to claim 1 , wherein the terpenoid copolymer is a copolymer of terpenoid and phenol.4. The allergen reducing agent according to claim 3 , wherein the copolymer of terpenoid and phenol has a hydroxyl number of 10 to 250 mgKOH/g.5. The allergen reducing agent according to claim 1 , wherein the terpenoid is monoterpene.6. The allergen reducing agent according to claim 5 , wherein the monoterpene is limonene or pinene.7. The allergen reducing agent according to claim 1 , wherein a double bond derived from the terpenoid is hydrogenated by a reaction with hydrogen.8. A processed product that comprises the allergen reducing agent of fixed to a surface of the processed product.9. A coating material that contains the allergen reducing agent of claim 1 , and a curable resin.10. A wood building material that comprises a single or multiple functional layers on a surface of a wood base claim 9 , wherein a layer forming the outermost surface of the single or multiple functional layers is a cured coating of the coating material of claim . The present invention relates to allergen reducing agents, and processed products, coating materials, and wood building materials using same.In Japan, one in three people is said to suffer from allergic diseases such as atopic dermatitis, bronchial asthma, and allergic rhinitis. Allergic diseases are caused by substances such as mites, pollen, fungi, and pet hairs. Particularly problematic are the allergens from house dust mites, which account for 70% or more ...

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Номер записи: 70
23-05-2013 дата публикации

FUNCTIONALIZATION OF AND USE OF FUNCTIONALIZED SECOND HARMONIC GENERATING NANOPROBES

Номер: US20130129628A1
Автор: Culic-Viskota Jelena, Dempsey William P., Fraser Scott E., Pantazis Periklis
Принадлежит: California Institute of Technology

Functionalized second harmonic nanoprobes for imaging samples and a method of using such probes to monitor the dynamics different processeses using a variety of imaging techniques are provided. The functionalized second harmonic generating (SHG) nanoprobes are comprised of various kinds of nanocrystalline materials that do not possess an inversion symmetry and therefore are capable of generating second harmonic signals that can then be detected by conventional two-photon microscopy, and are provided with functional surface modifications that allow for targeted imaging of a variety of biological and non-biological processes and structures such as cell signaling, neuroimaging, protein conformation probing, DNA conformation probing, gene transcription, virus infection and replication in cells, protein dynamics, tumor imaging and cancer therapy evaluation and diagnosis as well as quantification in optical imaging. 1. A method of functionalizing second harmonic generating probe nanostructure comprising:providing a probe nanostructure formed from a nanocrystalline material capable of exposing free surface hydroxyls, the probe nanostructure defining an outer surface and having no inversion symmetry such that it generates a second harmonic emission when radiated by an external excitation source;hydroxylating the probe nanostructure to form an activated outer surface thereof;attaching a plurality of modifying molecules having amine terminal groups to the hydroxylates of the activated outer surface of the probe nanostructure to form a functionalization platform on said outer surface of the probe nanostructure; andfunctionalizing the amine terminal groups of the functionalization platform with a plurality of functionalization molecules to form a functionalized probe nanostructure.2. The method of claim 1 , wherein the nanocrystalline material is selected from the group consisting of BaTiO claim 1 , SiC claim 1 , ZnO claim 1 , LiNbO claim 1 , KNbO claim 1 , KTiOPO claim 1 , Fe( ...

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Номер записи: 71
23-05-2013 дата публикации

NOVEL POLYMER, METHOD FOR MANUFACTURING THE SAME, AND FILM

Номер: US20130130012A1
Автор: Fujitomi Shintaro, Okada Takashi, Okaniwa Motoki, Uno Takaaki
Принадлежит: JSR Corporation

A polymer comprising: at least one structural unit (i) selected from the group consisting of a structural unit represented by formula (1) below and a structural unit represented by formula (2) below, wherein a terminal structure of said polymer is independently a structural unit represented by formula (5) below or a structural unit represented by formula (6) below. 3. The polymer according to claim 2 , wherein a molar ratio of the structural unit (i) to the structural unit (ii) in the polymer is from 50:50 to 100:0.4. The polymer according to claim 1 , wherein weight average molecular weight determined by gel permeation chromatography (GPC) relative to polystyrene is from 5 claim 1 ,000 to 500 claim 1 ,000.6. A method for manufacturing the polymer according to claim 1 , the method comprising a step of reacting: [{'br': None, '[Chem. 12]'}, {'br': None, 'sub': 'p', 'M\ue8a0OR)\u2003\u2003(13)'}], 'the component (A), the component (B) and a compound represented by formula (13) belowin formula (13), M is a metal atom; R is a monovalent organic group having from 1 to 18 carbons; and “p” indicates the valency of the metal atom.7. A polymer composition comprising the polymer described in and an organic solvent.8. A film comprising the polymer described in .9. The film according to claim 8 , wherein the film claim 8 , when having a thickness of 30 μm claim 8 , has a total light transmittance in accordance with JIS K7105 transparency testing methods of not less than 85%.10. The film according to claim 8 , wherein when the film is dissolved in dimethylacetamide to obtain a solution and the concentration of the polymer in the solution is 10 wt % claim 8 , a YI value (yellow index) of the solution is not greater than 7.11. The film according to claim 8 , wherein claim 8 , when the film has a thickness of 30 μm claim 8 , retardation (Rth) in a thickness direction is not greater than 200 nm. The present invention relates to a novel polymer, a method for manufacturing the same, ...

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Номер записи: 72
23-05-2013 дата публикации

PROCESS FOR PREPARING POLYMER POLYOLS

Номер: US20130131204A1
Автор: Fennis Paulus Jacobus, Lelieveld Martinus Johannes Maria
Принадлежит:

The invention relates to a process for the preparation of a polymer polyol, which process comprises mixing in a reactor vessel a base polyol, one or more ethylenically unsaturated monomers, a polymerization initiator, optionally a macromer, and optionally a chain transfer agent, and polymerizing the mixture thus obtained at a temperature of 50 to 200 ° C., wherein the monomer(s) and initiator are dosed simultaneously to the reactor vessel and wherein during the time period of simultaneously dosing the monomer(s) and initiator the dosing weight ratio of initiator to monomer(s) is increased. 1. A process for the preparation of a polymer polyol , which process comprises mixing in a reactor vessel a base polyol , one or more ethylenically unsaturated monomers , a polymerization initiator , optionally a macromer , and optionally a chain transfer agent , and polymerizing the mixture thus obtained at a temperature of 50 to 200° C. , wherein the monomer(s) and initiator are dosed substantially simultaneously to the reactor vessel and wherein during the time period of substantially simultaneously dosing the monomer(s) and initiator the dosing weight ratio of initiator to monomer(s) is increased.2. The process of claim 1 , wherein the initiator comprises a peroxide compound.4. The process of claim 3 , wherein at least one of R5 claim 3 , R6 and R7 is an alkyl group and is selected from a methyl group claim 3 , an ethyl group or a tertiary butyl group5. The process of claim 3 , wherein R2 is selected from: tertiary-butyl claim 3 , 1 claim 3 ,1-dimethylpropyl claim 3 , 1 claim 3 ,1-dimethylbutyl claim 3 , 1 claim 3 ,1 claim 3 ,3-trimethylbutyl claim 3 , 1 claim 3 ,1 claim 3 ,3 claim 3 ,3-tetramethylbutyl claim 3 , 1 claim 3 ,1 claim 3 ,2-trimethylpropyl claim 3 , 1 claim 3 ,1 claim 3 ,2 claim 3 ,2-tetramethylpropyl or 1 claim 3 ,1 claim 3 ,2 claim 3 ,2-tetramethylbutyl.7. The process of claim 6 , wherein R2 is 1 claim 6 ,1-dimethylbutyl claim 6 , 1 claim 6 ,1 claim 6 ,3- ...

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Номер записи: 73
23-05-2013 дата публикации

PROCESS FOR PREPARING POLYMER POLYOLS

Номер: US20130131205A1
Автор: Fennis Paulus Jacobus, Karzijn Willem, Lelieveld Martinus Johannes Maria
Принадлежит:

The invention relates to a process for the preparation of a polymer polyol which is at most 60 wt. %, which process comprises mixing a base polyol, one or more ethylenically unsaturated monomers, a polymerization initiator, optionally a macromer, and optionally a chain transfer agent, and polymerizing the mixture thus obtained at a temperature of 50 to 200° C., optionally below 120 C, wherein the initiator is of formula R—C(═O)—O—O—R(I) wherein Ris an alkyl group and Ris an alkyl group of formula —C(R)(R)—C(R)(R)(R) (II) wherein Rand Rare the same or different and are an alkyl group, R, Rand Rare the same or different and are a hydrogen atom or an alkyl group. 1. A process for the preparation of a polymer polyol having a solid polymer content which is at most 60 wt. % , which process comprises mixing a base polyol , one or more ethylenically unsaturated monomers , a polymerization initiator , optionally a macromer , and optionally a chain transfer agent , and polymerizing the mixture thus obtained at a temperature of below 120° C. , wherein the initiator is of formula{'br': None, 'R1—C(═O)—O—O—R2\u2003\u2003(I)'} {'br': None, '—C(R3)(R4)—C(R5)(R6)(R7)\u2003\u2003(II)'}, 'wherein R1 is an alkyl group and R2 is an alkyl group of formula'}wherein R3 and R4 are the same or different and are an alkyl group, R5, R6 and R7 are the same or different and are a hydrogen atom or an alkyl group.2. The process of claim 1 , wherein R1 is an alkyl group having up to 10 carbon atoms.3. The process of claim 1 , wherein at least one of R5 claim 1 , R6 and R7 is an alkyl group and is selected from a methyl group claim 1 , an ethyl group or a tertiary butyl group4. The process of claim 1 , wherein R2 is selected from: tertiary-butyl claim 1 , 1 claim 1 ,1-dimethylpropyl claim 1 , 1 claim 1 ,1-dimethylbutyl claim 1 , 1 claim 1 ,1 claim 1 ,3-trimethylbutyl claim 1 , 1 claim 1 ,1 claim 1 ,3 claim 1 ,3-tetramethylbutyl claim 1 , 1 claim 1 ,1 claim 1 ,2-trimethylpropyl claim 1 , 1 claim 1 , ...

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Номер записи: 74
23-05-2013 дата публикации

Processes, Products, and Compositions Having Tetraalkylguanidine Salt of Aromatic Carboxylic Acid

Номер: US20130131276A1
Автор: Burdeniuc Juan Jesus, Huhtasaari Matti Sakari
Принадлежит: AIR PRODUCTS AND CHEMICALS, INC.

Disclosed are processes, products, and compositions having tetraalkylguanidine salt of aromatic acid. The processes include providing a pre-mix comprising an aromatic carboxylic acid component and contacting a tetraalkylguanidine with the aromatic carboxylic acid component in the pre-mix to form the tetraalkylguanidine salt of aromatic carboxylic acid or producing a catalyst composition by contacting the tetraalkylguanidine with the aromatic carboxylic acid component to form the tetraalkylguanidine salt of aromatic carboxylic acid. The compositions include the tetraalkylguanidine salt of aromatic carboxylic acid. The product is formed by the tetraalkylguanidine salt of aromatic carboxylic acid. 1. A process , comprising:providing a pre-mix comprising an aromatic carboxylic acid component;contacting a tetraalkylguanidine with the aromatic carboxylic acid component in the pre-mix to form a tetraalkylguanidine salt of aromatic carboxylic acid.2. The process of claim 1 , wherein the pre-mix comprises one or more of benzoic acid claim 1 , phthalic acid claim 1 , phenyl-propionic acid claim 1 , and salicylic acid.3. The process of claim 1 , wherein the pre-mix further comprises a polyol component.4. The process of claim 3 , wherein the pre-mix further comprises at least one member selected from the group consisting of surfactant component claim 3 , a blowing agent component claim 3 , and a crosslinking component.5. The process of claim 3 , wherein the polyol component comprises a polyether polyol and a grafted polyether polyol containing copolymerized styrene and acrylonitrile.6. The process of claim 3 , wherein the polyol component comprises a natural oil or fat polyol.7. The process of claim 3 , wherein the polyol component comprises a polyester polyol.8. The process of claim 1 , wherein the pre-mix further comprises a tertiary amine catalyst component.9. The process of claim 8 , wherein the tertiary amine catalyst component comprises an isocyanate reactive group.10. ...

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Номер записи: 75
23-05-2013 дата публикации

SYNTHESIS OF HIGH MOLECULAR WEIGHT PEO USING NON-METAL INITIATORS

Номер: US20130131309A1
Автор: Eitouni Hany Basam, Pistorino Jonathan, Sivanandan Kulandaivelu, Yang Jin
Принадлежит: Seeo, Inc

A new synthetic method to prepare high molecular weight poly(ethylene oxide) with a very narrow molecular weight distribution (PDI<1.5) is described. The method involves a metal free initiator system, thus avoiding dangerous, flammable organometallic compounds. 1. A method of synthesizing metal-free , high molecular weight polymers with low polydispersity , comprising the steps of:a) providing a mixture of an alcohol and a solvent;{'sub': '4', 'b) adding t-BuPto the mixture to make a metal-free initiator;'}c) adding monomers to the initiator;d) allowing the monomers and the initiator to react to form a metal-free, high molecular weight polymers with a polydispersity less than 1.5.2. The method of wherein the alcohol is selected from the group consisting of bisphenol-A claim 1 , 2 claim 1 ,5-dimethyl-2 claim 1 ,5-hexanediol claim 1 , phenol claim 1 , and t-butyl alcohol.3. The method of wherein the solvent is selected from the group consisting of tetrahydrofuran claim 1 , toluene claim 1 , benzene claim 1 , and DMSO.4. The method of wherein the monomers are selected from the group consisting of ethylene oxide claim 1 , substituted oxyranes claim 1 , ethylene sulfide claim 1 , substituted cyclic sulfides claim 1 , cyclic esters claim 1 , lactides claim 1 , and substituted forms of these monomers.5. The method of wherein the polydispersity is 1.1 or less.6. The method of wherein the high molecular weight polymers have a weight between about 20 and 500 kDa.7. The method of wherein the allowing step d comprises:stirring;maintaining a temperature;allowing the reaction to proceed for at least about 12 hours.8. A method of synthesizing metal-free claim 1 , high molecular weight PEO with low polydispersity claim 1 , comprising the steps of:a) providing a mixture of alcohol and THF;{'sub': '4', 'b) adding t-BuPto the mixture to make a metal-free initiator'}c) adding EO monomers to the initiatord) allowing the monomers and the initiator to react to form metal-free, high ...

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Номер записи: 76
30-05-2013 дата публикации

Antistatic antireflection film, method for manufacturing antistatic antireflection film, polarizing plate and image display device

Номер: US20130135726A1
Автор: Daiki Wakizaka, Kenichi Fukuda
Принадлежит: Fujifilm Corp

An antistatic antireflection film, including; a support; a hardcoat layer formed from a composition for a hardcoat layer containing at least a compound having a quaternary ammonium salt group; and a low refractive index layer formed from a composition for a low refractive index layer containing at least the following (a), (b), (c) and (d), in this order, wherein, (a) is an ethylenically unsaturated group-containing fluoropolymer, (b) is a fluorine-containing polyfunctional monomer having a surface free energy of 23 mN/m or more when a film is formed alone, four or less —CF 3 groups in a molecule, a fluorine content of 30% or more, and at least three reactive functional groups in one molecule, (c) is hollow silica fine particles having an average particle size of 10 nm to 100 nm, and (d) is a compound having a dimethylsiloxane structure.

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Номер записи: 77
06-06-2013 дата публикации

Acid Salt Forms of Polymer-Drug Conjugates and Alkoxylation Methods

Номер: US20130143909A1
Автор: Bray Brian, Chong Anthony O., Handley John R., Joshi Bhalchandra V., Kozlowski Antoni, Lavaty Greg, Lee Seoju, McManus Samuel P., Nie Shaoyong, Schaefer Anthony G., Spence Patrick L., Swallow David, Tipnis Sachin
Принадлежит: Nektar Therapeutics

Among other aspects, provided herein is a mixed-acid salt of a water-soluble polymer-drug conjugate, along with related methods of making and using the same. The mixed-salt acid salt is stably formed, and appears to be more resistant to hydrolytic degradation than the corresponding predominantly pure acid salt or free base forms of the polymer-drug conjugate. The mixed acid salt is reproducibly prepared and recovered, and provides surprising advantages over non-mixed acid salt forms of the water-soluble polymer drug conjugate. 1. A composition comprising mixed salts of water-soluble polymer-active agent conjugates , wherein the active agent in the conjugate has at least one basic amine group , and further wherein for each amine group within the active agent , the amine group is either protonated or unprotonated , where any given protonated amine group is an acid salt form of an inorganic acid or trifluoroacetic acid (TFA).2. (canceled)3. (canceled)4. The composition of claim 1 , where the inorganic acid is hydrochloric acid.5. (canceled)6. (canceled)7. The composition of claim 1 , wherein said water soluble polymer is a poly(ethylene glycol).8. (canceled)9. (canceled)11. (canceled)12. (canceled)13. (canceled)14. The composition of claim 4 , wherein about 25-40 mole percent of the amine groups within the active agent are protonated as the HCl salt claim 4 , and about 5-35 mole percent of the amine group within the active agent are non-protonated (i.e. claim 4 , as the free base).15. (canceled)16. (canceled)17. A method for preparing a mixed salt of a water-soluble polymer-active agent conjugate claim 4 , comprising the steps of:(i) deprotecting an inorganic acid salt of an amine-containing active agent in protected form by treatment with trifluoroacetic acid (TFA) to form a deprotected inorganic acid/TFA mixed salt,(ii) coupling the deprotected inorganic acid/TFA mixed salt of step (i) with a water soluble polymer reagent in the presence of a base to form a polymer- ...

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Номер записи: 78
06-06-2013 дата публикации

WATER-SOLUBLE PHYTOSTEROL DERIVATIVES FOR REDUCING CHOLESTEROL AND PREPARATION THEREOF

Номер: US20130144076A1
Автор: Chatla Narayana, Rambacher Robert William, Yao Yao
Принадлежит: KIP BIOTECH LLC

Provided herein is a method of preparing a composition of a phytosterol derivative comprising a phytosterol intermediate coupled to a water-soluble carrier. The method controls the molecular structure of the product, resulting in phytosterol derivatives which are soluble in water at high concentration. The phytosterol derivatives provided herein are useful as ingredients for foods and pharmaceuticals, and have cholesterol-reducing effects. 1. A method of making a compound of Formula I:{'br': None, 'X-L-P'}or a salt form thereof, wherein:X is a phytosterol;L is a linker; and (a) reacting a mixture comprising X-L, P, an acid, and a first organic solvent, wherein the molar ratio of X-L to P is from about 1:1.5 to about 1:10;', '(b) neutralizing said mixture of step (a) and adding a second organic solvent;', '(c) washing said solution from step (b) with brine; and', '(d) isolating a composition comprising said compound of Formula I., 'P is a water-soluble carrier selected from the group consisting of polyethylene glycol having an average molecular weight of about 200 to about 2000, polyalcohol, and polyether; said method comprising2. The method of claim 1 , wherein said method further comprises recrystallizing the compound of Formula I.3. The method of claim 1 , wherein said molar ratio of X-L to P is from about 1:2 to about 1:6.4. (canceled)5. The method of claim 1 , wherein said phytosterol is selected from the group consisting of: sitosterol claim 1 , sitostanol claim 1 , campesterol claim 1 , campestanol claim 1 , stigmasterol claim 1 , stigmastanol claim 1 , ergosterol claim 1 , ergostanol claim 1 , avenasterol claim 1 , avenastanol claim 1 , spinasterol claim 1 , spinastanol claim 1 , brassicasterol claim 1 , brassicastanol claim 1 , clionasterol claim 1 , clionastanol and mixtures thereof.6. (canceled)7. The method of claim 1 , wherein said linker is a dicarboxylate.8. The method of claim 7 , wherein said dicarboxylate is selected from the group consisting of ...

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Номер записи: 79
20-06-2013 дата публикации

Multi-arm polymer prodrugs

Номер: US20130158062A1
Автор: Michael David Bentley, Tacey X. Viegas, Xuan Zhao, Zhongxu Ren
Принадлежит: Nektar Therapeutics

Provided herein are water-soluble prodrugs, compositions comprising such prodrugs, and related methods of making and administering the same. The prodrugs of the invention comprise a water-soluble polymer having three or more arms, at least three of which are typically covalently attached to an active agent, e.g., a small molecule. The conjugates of the invention provide an optimal balance of polymer size and structure for achieving improved drug loading, since the conjugates of the invention possess three or more active agents releasably attached to a multi-armed water-soluble polymer. The prodrugs of the invention are therapeutically effective, and exhibit improved properties in-vivo when compared to unmodified parent drug.

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Номер записи: 80
20-06-2013 дата публикации

LIQUID CURABLE EPOXY RESIN COMPOSITION AND ADHESIVE AGENT CONTAINING SAME

Номер: US20130158231A1
Автор: Amaike Masato, Kamegaya Naoyuki, Nomura Tomoya, Ono Kazuo
Принадлежит: NIPPON SODA CO., LTD.

An object of the present invention is to provide a curable epoxy resin composition containing an epoxy resin, wherein the composition is excellent in storage stability and curing characteristics and provides a cured product excellent in characteristics, particularly organic solvent resistance; an adhesive agent consisting of the composition; and an adhesive agent consisting of a curable epoxy resin composition excellent in adhesive strength. The curable epoxy resin composition of the present invention is a liquid curable epoxy resin composition containing the following (A) and (B): (A) an epoxy resin or an epoxy-polyester hybrid resin; and (B) a clathrate containing the following (b1) and (b2): (b1) at least one compound selected from the group consisting of a carboxylic acid compound represented by the formula A(COOH)(wherein A represents a C1-C6 chain hydrocarbon group optionally having a substituent, a C3-C10 monocyclic hydrocarbon group optionally having a substituent, or a C6-C10 bicyclic hydrocarbon group optionally having a substituent; and a represents 2 or 3) and the like; and (b2) at least one compound selected from the group consisting of a compound represented by formula (II) and 1,8-diazabicyclo[5.4.0]undecene-7. 4. The liquid curable epoxy resin composition according to claim 3 , wherein the compound represented by formula (V) is 5-t-butylisophthalic acid claim 3 , 5-hydroxyisophthalic acid claim 3 , or 5-nitroisophthalic acid.5. An adhesive agent containing a liquid curable epoxy resin composition according to .6. The adhesive agent according to claim 5 , wherein the number of moles of component (b2) in component (B) is 0.008 to 0.4 with respect to 1 mol of epoxy group of component (A).8. An adhesive agent containing a liquid curable epoxy resin composition according to .9. An adhesive agent containing a liquid curable epoxy resin composition according to .10. An adhesive agent containing a liquid curable epoxy resin composition according to .11. The ...

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Номер записи: 81
04-07-2013 дата публикации

BLOCK COPOLYMERS ON THE BASIS OF (METH)ACRYLATE

Номер: US20130172511A1
Автор: Balk Sven, Erb Volker, Fengler Stephan, Franken Uwe, Kautz Holger, Kinzelmann Hans-Georg, Kuppert Dirk, Moeller Thomas, Pieroth Rebecca, Staschik Dorothea, Zander Lars
Принадлежит:

The invention relates to block copolymers produced by means of controlled polymerization and that have at least one block A or B comprising (meth)acrylate monomers and copolymerizable monomers, and a block P on the basis of functionalized polymers. 2. The block copolymer according to claim 1 , wherein all OH claim 1 , SH claim 1 , RNH groups of P are functionalized with an initiator building block and reacted to give an A and/or B block.3. The block copolymer according to claim 1 , wherein block A and/or block B is a multi-block with the structure (AB)n or (BA)n claim 1 , where n=1 to 10.4. The block copolymer according to claim 1 , wherein block A is a homopolymer or copolymer claim 1 , taking the form of a gradient or random polymer in the case of a copolymer.5. The block copolymer according to claim 1 , wherein block P has a functionality of 1 to 10.6. The block copolymer according to claim 1 , wherein blocks A or B each have one or more functional groups.7. The block copolymer according to claim 6 , wherein blocks A or B lying at the end of the polymer have one functional group in the terminal position.8. The block copolymer according to claim 1 , wherein block A is largely or exclusively constructed from vinyl-substituted aromatic monomers.9. The block copolymer according to claim 1 , wherein blocks A and B are produced by ATRP polymerization.10. The block copolymer according to claim 1 , wherein the polymer building block P is a polyether diol or polyether triol produced on the basis of ethylene glycol claim 1 , propylene glycol or tetrahydrofuran claim 1 , or a polyester diol or triol produced from aliphatic and/or aromatic dicarboxylic acids with low-molecular-weight diols claim 1 , in particular having a molecular weight of 400 to 20 claim 1 ,000 g/mol.11. A method for producing block copolymers comprising a block P and at least one block A and block B claim 1 , wherein a polymer building block containing OH claim 1 , SH claim 1 , RNH groups is used as ...

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Номер записи: 82
11-07-2013 дата публикации

GOLD PARTICLES AND METHODS OF MAKING AND USING THE SAME IN CANCER TREATMENT

Номер: US20130177523A1
Автор: GHANDEHARI Hamid, GORMLEY Adam, Larson Nate, Ray Abhijit
Принадлежит: UNIVERSITY OF UTAH RESEARCH FOUNDATION

Described herein are gold particles that can be used to reduce tumor proliferation and treat cancer. In certain aspects, the gold particles can be modified in order to enhance selectivity and uptake of the particles by cancer cells. In certain aspects, the modified gold particles have a targeting group attached to the particle via a linker. The gold particles described herein can be used in combination with other anti-cancer agents in order to enhance overall cancer treatment. Methods for making and using the gold particles are also described herein. 2. The composition of claim 1 , wherein the gold particle is a spherical particle claim 1 , a cage claim 1 , a disc or a rod.3. The composition of claim 1 , wherein the gold particle is a rod having a diameter from 5 nm to 100 nm and length from 10 nm to 800 nm.4. The composition of claim 1 , wherein the linker comprises a hydrophobic linker.5. The composition of claim 1 , wherein the linker comprises a hydrophilic linker.6. The composition of claim 5 , wherein the hydrophilic linker comprises the polymerization product of hydroxyalkyl methacrylate (HEMA) claim 5 , hydroxyalkyl acrylate claim 5 , N-vinyl pyrrolidone claim 5 , N-methyl-3-methylidene-pyrrolidone claim 5 , allyl alcohol claim 5 , N-vinyl alkylamide claim 5 , N-vinyl-N-alkylamide claim 5 , acrylamides claim 5 , methacrylamide claim 5 , (lower alkyl)acrylamides and methacrylamides claim 5 , hydroxyl-substituted (lower alkyl)acrylamides and methacrylamides claim 5 , and any combination thereof.7. The composition of claim 5 , wherein the hydrophilic linker comprises a polymer of ethylene glycol claim 5 , propylene glycol claim 5 , or block co-polymers thereof.8. The composition of claim 5 , wherein the hydrophilic linker comprises poly(ethylene glycol) having a molecular weight from 100 to 30 claim 5 ,000.9. The composition of claim 1 , wherein the functional group is a hydroxyl group claim 1 , an alkoxy group claim 1 , a carboxy group claim 1 , a carbonyl ...

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Номер записи: 83
11-07-2013 дата публикации

LOW SURFACE ENERGY TOUCH SCREENS, COATINGS, AND METHODS

Номер: US20130177737A1
Автор: BROWN James F.
Принадлежит: CYTONIX, LLC

Substrates, surfaces, assemblies, kits, compositions, and methods are provided for forming touch screens and other appliance surfaces exhibiting good hydrophobicity, oleophobicity, and abrasion resistance. Methods are provided for increasing a population density of hydroxyl groups on a touch surface of a touch screen substrate without affecting the compressive strength of the back surface. The treated touch surface of the substrate can then be coated with a coating that includes an organo-metalic and/or silane, for example, a fluorosilane such as a perfluoropolyether alkoxysilane. A substrate can retain its compressive resistance to breakage by impact applied to the touch surface while minimizing any decrease in compressive strength against impact against the touch surface. Examples of such substrates include touch screens for mobile and desktop electronic devices, components of 3D display devices, and components for electrowetting display devices. 1. A perfluoropolyether silane of the formula:{'br': None, 'sub': f', '2', '3', 'x', 'z, 'i': 'x', 'sup': '1', 'R—[CRSi(Y)-(R)]'}{'sub': f', '1', '8, 'sup': '1', 'wherein Rrepresents a pendant polyfluoropolyether, Rrepresents a C-Calkyl group, Y represents a hydrolysable group independently selected from a chloro group, an alkoxy group, an acyloxy group, and an aryloxy group, each R independently represents hydrogen or an alkyl group of 1 to 4 carbon atoms, z is 2, 3, or 4, and each x is independently 0 or 1.'}2. The perfluoropolyether silane of claim 1 , wherein the pendant perfluoropolyether is a K type or Y type perfluoropolyether.3. The perfluoropolyether silane of claim 1 , wherein the pendant perfluoropolyether has a molecular weight of from about 500 to about 10 claim 1 ,000 amu.4. The perfluoropolyether silane of claim 1 , wherein the pendant perfluoropolyether has a molecular weight of from about 2000 to about 5000 amu.5. The perfluoropolyether silane of claim 1 , wherein the hydrolysable group is selected from ...

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Номер записи: 84
11-07-2013 дата публикации

Adhesive composition containing resin having carbon-carbon multiple bond

Номер: US20130177763A1
Автор: Hiroshi Ogino, Mamoru Tamura, Tomoyuki Enomoto
Принадлежит: Nissan Chemical Corp

An adhesive composition has a polymer that contains a unit structure of Formula (1): L 1 -O-T 1 -O  Formula (1) (where L 1 is an arylene group or a combination of an arylene group and a sulfonyl group or a carbonyl group, and T 1 is a fluoroalkylene group, a cyclic alkylene group, an arylene group having a substituent, or a combination of an arylene group optionally having a substituent and a fluoroalkylene group or a cyclic alkylene group) and contains, at a terminal or in a side chain or the main chain, at least one group containing a structure of Formula (2-A), a structure of Formula (2-B), or both structures:

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Номер записи: 85
11-07-2013 дата публикации

MULTI-ARMED, MONOFUNCTIONAL, AND HYDROLYTICALLY STABLE DERIVATIVES OF POLY(ETHYLENE GLYCOL) AND RELATED POLYMERS FOR MODIFICATION OF SURFACES AND MOLECULES

Номер: US20130177961A1
Автор: CALICETI Paolo, Harris J. Milton, SCHIAVON Oddone, VERONESE Francesco Maria
Принадлежит: Nektar Therapeutics

Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure 2. The method of claim 1 , wherein mPEG-P—C(R)(Z)-Q-mPEG is formed in step (i) in a single reaction step.3. The method of claim 1 , wherein the conditions effective to form mPEG-P—C(R)(Z)-Q-mPEG comprise at least two reaction steps.4. The method of claim 3 , wherein the at least two reaction steps comprise reaction of mPEG-W with the linker molecule claim 3 , X—C(Y)(R)—Z claim 3 , to form a mono-substituted intermediate polymer product claim 3 , mPEG-P—C(R)(Z)-Q claim 3 , followed by reaction of mPEG-P—C(R)(Z)-Q with mPEG-W′ claim 3 , a monomethoxypoly(ethylene glycol) polymer comprising a single reactive moiety claim 3 , W′ claim 3 , where W′ can be the same or different from W claim 3 , to form mPEG-P—C(R)(Z)-Q-mPEG.5. The method of claim 4 , wherein prior to reaction of mPEG-P—C(R)(Z)-Q with mPEG-W′ claim 4 , mPEG-P—C(R)(Z)-Q is recovered.6. The method of claim 1 , wherein mPEG-W has a molecular weight from about 100 to 100 claim 1 ,000 daltons.7. The method of claim 1 , wherein Z comprises a single ionizable reactive site that is selected from carboxyl claim 1 , hydroxyl claim 1 , and amino.8. The method of claim 1 , wherein the linker molecule is lysine or is a diamino alcohol.9. The method of claim 8 , wherein the linker molecule is lysine.10. The method of claim 1 , wherein the one or more polymeric impurities are selected from PEG diol claim 1 , mPEG-OH claim 1 , and mPEG-W.11. The method of claim 1 , wherein the single reactive moiety claim 1 , W claim 1 , is selected from the group consisting of active ester claim 1 , active carbonate claim 1 , aldehyde claim 1 , vinyl sulfone claim 1 , and iodoacetamide.12. The method of claim 10 , wherein the one or more polymeric impurities further comprise mPEG-P—C(R)(Z)-Q.13. The method of claim 1 , wherein the single reactive moiety W is an active ester and the linker molecule is lysine.14. The method of claim 1 , ...

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Номер записи: 86
11-07-2013 дата публикации

Advanced epoxy resin compositions

Номер: US20130178590A1
Автор: Bernhard Kainz, Jerry W. White, Ray E. Drumright, Robert E. Hefner, Jr., XIN Jin
Принадлежит: Dow Global Technologies LLC

An epoxy resin composition of the following chemical structure (I), where n is a number from 1 to about 3000; each m independently has a value of 0 or 1; each R0 is independently —H or —CH 3 ; each R 1 is independently —H or a C 1 to C 6 alkylene radical (saturated divalent aliphatic hydrocarbon radical), Ar is a divalent aryl group or heteroarylene group; and X is a cycloalkylene group, including a substituted cycloalkylene group, where the substituent group include an alkyl, cycloalkyl, an aryl or an aralkyl group or other substituent group, for example, a halogen, a nitro, or a blocked isocyanate, an alkyloxy group; the combination of cycloalkylene and alkylene groups and the combination of alkylene and cycloalkylene group with a bridging moiety in between.

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Номер записи: 87
11-07-2013 дата публикации

PROCESS FOR PREPARING EPOXY RESINS

Номер: US20130178601A1
Автор: Hefner, JR. Robert E.
Принадлежит: Dow Global Technologies LLC

A process for preparing an aliphatic or cycloaliphatic epoxy resin including the steps of: (I) reacting a mixture of (a) an aliphatic or cycloaliphatic hydroxyl containing material, (b) an epihalohydrin, (c) a basic acting substance, (d) a non-Lewis acid catalyst, and (e) optionally, a solvent, forming an epoxy resin composition; (II) subjecting the epoxy resin composition produced in step (I) to a separation process to remove (A) “light” components such as, for example, solvent used in the epoxidation reaction, if any, unreacted epihalohydrin, and co-products such as di(epoxypropyl)ether; (B) unreacted aliphatic or cycloaliphatic hydroxyl containing material, if any; (C) partially epoxidized aliphatic or cycloaliphatic hydroxyl containing material, such as, for example, MGE; (D) fully epoxidized aliphatic or cycloaliphatic hydroxyl containing material, such as, for example, DGE, such that the (E) aliphatic or cycloaliphatic polyfunctional epoxy resin product remaining contains no more than 50% by weight of said fully epoxidized aliphatic or cycloaliphatic hydroxyl containing material (D); and (III) recycling the isolated partially epoxidized aliphatic or cycloaliphatic hydroxyl containing material (C) and any mixtures of partially epoxidized aliphatic or cycloaliphatic hydroxyl containing material (C) with fully epoxidized aliphatic or cycloaliphatic hydroxyl containing material (D) from step (II) to a new reaction mixture of step (I). 1. A process for preparing an aliphatic or cycloaliphatic epoxy resin comprising the steps of:(I) reacting a mixture of (i) an aliphatic or cycloaliphatic hydroxyl containing material, (ii) an epihalohydrin, (iii) a basic acting substance, (iv) a non-Lewis acid catalyst, and (v) optionally, a solvent, forming an epoxy resin composition;(II) subjecting the epoxy resin composition produced in step (I) to a separation process to produce at least the following fractions: (A) a fraction of “light” components, if any; (B) a fraction of ...

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Номер записи: 88
18-07-2013 дата публикации

ANTIMICROBIAL POLYMERIC COMPOSITIONS

Номер: US20130183262A1
Автор: Chakrabarty Souvik, Chakravorty Asima, Oyesanya Olufemi O., Wynne Kenneth J., ZHANG Wei
Принадлежит:

A compound having the formula: 3. A polymer , comprising a polymerization product of:{'claim-ref': {'@idref': 'CLM-00001', 'claim 1'}, '(A) the compound of ;'}(B) one or more of an isocyanate, diisocyanate, or combination thereof;(C) optionally, a diol or diamine chain extender; and(D) optionally, a diol selected from the group polydimethylsiloxane diol, polytetramethylene oxide diol, polypropylene oxide diol, polyethylene oxide diol, polybutadiene diol, polyisobutylene diol, perfluorinated diol or a combination of two or more thereof.10. The composition of claim 9 , which is a blend of (a) and (b).19. A method claim 9 , comprising: (a) at least one selected from the group consisting of polyurethane polymer, polyurethane copolymer, or a combination thereof; and', '(b) at least one selected from the group consisting of non-polar solvent, pentane, cyclopentane, hexane, cyclohexane, benzene, toluene, 1,4-dioxane, chloroform, diethyl ether, polar aprotic solvent, tetrahydrofuran, dichloromethane, ethyl acetate, acetone, dimethylformamide, acetonitrile, dimethyl sulfoxide, propylene carbonate, or a combination thereof; and', '(c) at least one selected from the group consisting of polar protic solvent, water, methanol, ethanol, propanol, isopropanol, n-butanol, formic acid, or a combination thereof;, 'contactingand thereafter separating, to produce a purified polyurethane polymer, polyurethane copolymer, or a combination thereof.20. A method for making a polymer claim 19 , comprising the method of .21. A polymer claim 19 , produced by the method of .22. An article or device claim 3 , comprising the polymer of on a surface thereof.23. An article or device claim 7 , comprising the composition of on a surface thereof.24. An article or device claim 9 , comprising the composition of on a surface thereof.25. An article or device claim 15 , comprising the polymer of on a surface thereof.26. A method for killing a microbe claim 17 , comprising contacting said microbe with the ...

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Номер записи: 89
18-07-2013 дата публикации

Monomer composition containing unsaturated polyalkylene glycol ether-based monomer, method for producing composition thereof, polymer obtained using composition thereof, and method for producing polymer thereof

Номер: US20130184420A1
Автор: Hiroshi Kawabata
Принадлежит: NIPPON SHOKUBAI CO LTD

To provide a monomer composition containing an unsaturated polyalkylene glycol ether-based monomer and having excellent stability. Provided is a monomer composition containing an unsaturated polyalkylene glycol ether-based monomer represented by the following chemical formula (1): YO(R 1 O) n R 2   (1) [in the formula, Y represents an alkenyl group having 2 to 7 carbon atoms; R 1 O represents one or two or more types of oxyalkylene groups having 2 to 18 carbon atoms; n represents an average addition mole number of oxyalkylene groups and is a number of 5 to 500; and R 2 represents a hydrogen atom or a hydrocarbon group having 1 to 30 carbon atoms], an organic acid, and water, and having a pH of 4 to 13.

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Номер записи: 90
18-07-2013 дата публикации

POLYMERIC MATERIALS

Номер: US20130184427A1
Автор: Prescott John Kevin, Webster Graham Robert, Wilson Brian
Принадлежит: VICTREX MANUFACTURING LIMITED

A method of making a polymeric material is described, the method comprising contacting, for example polycondensing, a compound of formula 3. A polymeric material according to claim 1 , wherein said polymeric material has a Tm of less than 380° C.5. A polymeric material according to claim 4 , wherein the sum of the mole % of moieties IX are X in said polymeric material is at least 90 mole %.6. A polymeric material according to claim 5 , wherein the sum is at least 95 mole %.8. A polymeric material according to which is a tough crystalline thermoplastic polymeric material.9. A polymeric material according to claim 1 , wherein n represents 1.10. A polymeric material according to claim 1 , wherein the Tg of said polymeric material is at least 163° C. and is less than 170° C.11. A polymeric material according to claim 1 , which has a Tm of less than 378° C.12. A polymeric material according to claim 1 , wherein the ratio of the Tm to the Tg for said polymeric material is less than 2.32.15. A polymeric material according to which is a tough crystalline thermoplastic polymeric material.16. A polymeric material according to claim 14 , wherein n represents 1.18. A polymeric material according to claim 17 , wherein the sum of the mole % is at least 95 mole %.20. A polymeric material according to which is a tough crystalline thermoplastic polymeric material claim 17 , wherein n represents 1 claim 17 , the Tm is less than 378° C. and the ratio of the Tm to the Tg for said polymeric material is less than 2.32. This application is a Divisional of copending U.S. patent application Ser. No. 11/994,064, filed Apr. 24, 2008, which is is a U.S. nationalization under 35 U.S.C. §371 of International Application No. PCT/GB06/01954, filed May 26, 2006, which claims priority United Kingdom application no. 0605055.3, filed Mar. 13, 2006, and 0513621.3, filed Jul. 2, 2005. The disclosures set forth in the referenced applications are incorporated herein by reference in their entireties.This ...

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Номер записи: 91
01-08-2013 дата публикации

Synergistic biomolecule-polymer conjugates

Номер: US20130195799A1
Автор: Chyi Lee
Принадлежит: PEG BIOSCIENCES Inc

The synergistic biomolecule-polymer conjugates are the long-acting, in vivo controlled continuous-release and hybrid synergy systems of biomolecules that provide increased biological activities and enhanced pharmacological properties for achieving greater therapeutic efficacies.

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Номер записи: 92
08-08-2013 дата публикации

CHEMICALLY RESISTANT MEMBRANES, COATINGS AND FILMS AND METHODS FOR THEIR PREPARATION

Номер: US20130203873A1
Автор: Kedem Ora, Linder Charles, Oren Yoram
Принадлежит: BEN-GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY LTD.

There is provided herein a membrane or film comprising one or more aromatic ionomers covalently crosslinked through aryl-aryl (—Ar—Ar—), aryl-ether-aryl (—Ar—O—Ar—), aryl-sulfide-aryl (—Ar—S—Ar—), aryl-sulfone-aryl bonds, or any combination thereof, wherein said one or more aromatic ionomers further comprises at least one electron withdrawing group adapted to improve oxidant resistance of said membrane or film. 131-. (canceled)32. A membrane or film comprising:one or more aromatic ionomers covalently crosslinked through aryl-aryl (—Ar—Ar—), aryl-ether-aryl (—Ar—O—Ar—), aryl-sulfide-aryl (—Ar—S—Ar—), aryl-sulfone-aryl bonds, or any combination thereof, wherein said one or more aromatic ionomers further comprises at least one electron withdrawing group adapted to improve oxidant resistance of said membrane or film.33. The membrane or film according to claim 32 , wherein the covalently crosslinking was formed through diazonium reactions.34. The membrane or film according to claim 32 , wherein the electron withdrawing group is selected from a group consisting of a halide claim 32 , nitro group claim 32 , sulfonic group claim 32 , phosphonic group and carboxylic group.35. The membrane or film according to claim 34 , wherein the halide comprises F claim 34 , Cl claim 34 , Br or any combination thereof.36. The membrane or film according to claim 32 , wherein the electron withdrawing group is a nitro group.37. The membrane or film according to claim 32 , wherein the one or more aromatic ionomers comprise an aromatic condensation polymer comprising polysulfone (PSU) claim 32 , polyphenylsulfone (PPS) claim 32 , polyphenylene sulfone claim 32 , polyethersulfone (PES) claim 32 , polyetherketone (PEK) claim 32 , polyether ether ketone (PEEK) claim 32 , polyether ketone ether ketone claim 32 , a combination of polyether ketone and polysulfone claim 32 , polyphenylene sulfide claim 32 , phenylene sulfone claim 32 , a combination of sulfide and sulfone claim 32 , poly ether based ...

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Номер записи: 93
08-08-2013 дата публикации

CYCLOALIPHATIC CARBONATES AS REACTIVE DILUENTS IN EPOXY RESINS

Номер: US20130203894A1
Автор: Burton Bruce L.
Принадлежит: Huntsman Petrochemical LLC

Embodiments of the present invention disclose a method for limiting peak exotherm temperatures in epoxy systems comprising the step of: combining an amine hardener, an epoxy and a diluent to form an epoxy system, wherein the diluent is selected from the group consisting of: ethylene carbonate, propylene carbonate, butylene carbonate, delta-valerolactam, delta-valerolactone, gamma valerolactone, butyrolactam, beta butyrolactone, gamma butyrolactone, and combinations thereof. 1. A method for limiting peak exotherm temperatures in an epoxy system comprising the step of:combining an amine hardener, an epoxy, and a diluent to form an epoxy system;wherein the diluent is selected from the group consisting of: ethylene carbonate, propylene carbonate, butylene carbonate, delta-valerolactam, delta-valerolactone, gamma valerolactone, butyrolactam, beta butyrolactone, gamma butyrolactone, and combinations thereof.2. The method of wherein the diluent is propylene carbonate3. The method of wherein the diluent is selected from the group consisting of: delta-valerolactam claim 1 , delta-valerolactone claim 1 , gamma valerolactone claim 1 , butyrolactam claim 1 , beta butyrolactone claim 1 , gamma butyrolactone claim 1 , and combinations thereof.4. The method of wherein the epoxy system is substantially free of an aliphatic glycidyl ether.5. The method of wherein the aliphatic glycidyl ether comprises a diglycidyl ether of 1 claim 4 ,4-butane diol.6. The method of wherein the amine hardener comprises an aliphatic amine having an amine-hydrogen functionality greater than two amine hydrogens per molecule.7. The method of wherein the epoxy comprises a multifunctional polyglycidyl ether of dihydric phenol.8. The method of further comprising the step of heating the epoxy system.9. The method of further comprising the step of injecting claim 1 , filling claim 1 , or infusing the epoxy system into a mold.10. The method of wherein the mold is a wind blade mold.11. The method of claim 1 , ...

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Номер записи: 94
08-08-2013 дата публикации

POLYOXYMETHYLENE COPOLYMERS

Номер: US20130203958A1
Автор: Pottie Laurence, von Bernstorff Bernd-Steffen
Принадлежит: BASF SE

Specific polyoxymethylene copolymers are described with a weight-average molar mass (M) in the range from 5000 to 15 000 g/mol, and processes are described for producing these by polymerization of trioxane and optionally of comonomers in the presence of at least one cationic initiator and of at least one di(C-alkyl) acetal as regulator. 114-. (canceled)15. A polyoxymethylene copolymer with a weight-average molar mass (M) in the range from 5000 to 15 000 g/mol , at least 90% by weight of which , based on the polymer , derives from trioxane and butanediol formal as monomers , with a proportion of butanediol formal , based on the polymer , in the range from 0.5 to 4% by weight.16. The polymer according to claim 15 , wherein the weight-average molar mass (M) is from 6000 to 9000 g/mol.17. The polymer according to claim 15 , wherein the number-average molar mass (M) is from 3000 to 6000 g/mol.18. The polymer according to claim 15 , wherein the M/Mratio is in the range from 1.5 to 3.0.19. The polymer according to claim 15 , wherein with the proportion of butanediol formal claim 15 , based on the polymer claim 15 , in the range from 2.5 to 3% by weight claim 15 , the weight-average molar mass (M) is from 7000 to 7500 g/mol and the number-average molar mass (M) is from 3500 to 4100 g/mol.20. The polymer according to claim 15 , wherein the M/Mratio is in the range from 1.5 to 3.0.21. The polymer according to claim 19 , wherein the M/Mratio is in the range from 1.5 to 2.45.22. The polymer according to claim 15 , which derives exclusively from trioxane and butanediol formal as monomers.23. The polymer according to claim 15 , which has claim 15 , at the chain ends claim 15 , based on the polymer claim 15 , from 3 to 6% by weight of moieties of the formula —OR claim 15 , where R is C-alkyl.24. The polymer according to claim 23 , wherein production of the polymer uses claim 23 , based on the polymer claim 23 , from 3.75 to 4.25% by weight claim 23 , of methylal claim 23 , or an ...

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Номер записи: 95
08-08-2013 дата публикации

Ionic Viscoelastics and Viscoelastic Salts

Номер: US20130204010A1
Автор: Mark W. Grinstaff, Michel Wathier
Принадлежит: Boston University

One embodiment of the present invention relates to ionic liquids and ionic viscoelastics formed between [1] a small molecule or macromolecule containing two or more cations; and [2] a small molecule or macromolecule containing two or more anions. Another embodiment of the invention is the use of the inventive ionic liquids and ionic viscoelastics, formed between a small molecule or macromolecule containing two or more cations and a small molecule or macromolecule containing two or more anions, to form a crosslinked network. In certain embodiments, the ionic liquids formed can be viscous liquids, viscous liquid formed networks, or viscoelastic networks/gels. In certain embodiments, the ionic material of the invention may be used for a variety of applications including, but not limited to, lubricants, additives, gas separation, liquid separation, membranes, fuel cells, sensors, batteries, coatings, heat storage, liquid crystals, biocompatible fluids, solvents, and electronic materials.

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Номер записи: 96
22-08-2013 дата публикации

AMPHIPHILIC MACROMOLECULES FOR NUCLEIC ACID DELIVERY

Номер: US20130217753A1
Автор: Gu Li, Harmon Alex, Roth Charles M., Sparks Sarah M., Uhrich Kathryn E., Waite Carolyn
Принадлежит: Rutgers, The State University of New Jersey

The invention provides amphiphilic macromolecules that are useful for delivering nucleic acids to cells and that are useful as delivery agents for gene therapy. 2. The compound of wherein B is absent or the group —NH(-A-NH—)—(CH)—NH—C(═O)—CH—.3. The compound of wherein B is —NH(-A-NH—)—(CH)—NH—C(═O)—CHCH—.8. The compound of wherein m is an integer from 1 to 20 and n is an integer from 1 to 20.9. The compound of wherein m is 1 claim 1 , 2 claim 1 , 3 claim 1 , or 4.10. The compound of wherein n is 1 claim 1 , 2 claim 1 , 3 claim 1 , or 4.11. The compound of wherein p is an integer from 20 to 200.12. The compound of wherein p is about 109.13. The compound of wherein each r is independently an integer from 0 to 20.14. The compound of wherein each r is independently 6 claim 1 , 7 claim 1 , 8 claim 1 , 9 claim 1 , 10 claim 1 , 11 claim 1 , 12 claim 1 , 13 claim 1 , 14 claim 1 , or 15.15. The compound of wherein: m is 2 claim 1 , 3 claim 1 , 4 claim 1 , or 5; n is 2 claim 1 , 3 claim 1 , 4 claim 1 , or 5; p is an integer from about 95 to about 125; and each r is independently 6 claim 1 , 7 claim 1 , 8 claim 1 , 9 claim 1 , 10 claim 1 , 11 claim 1 , 12 claim 1 , 13 claim 1 , 14 claim 1 , or 15.19. A composition comprising a compound of formula I or a salt thereof as described in and a nucleic acid.20. The composition of further comprising one or more lipids.21. A method for delivering a nucleic acid into a cell comprising contacting the cell with a composition comprising a compound of formula I or a salt thereof as described in and the nucleic acid under conditions such that the nucleic acid is delivered into the cell.22. The method of wherein the composition further comprises one or more lipids. This application is a continuation-in-part of U.S. patent application Ser. No. 13/402,793, filed Feb. 22, 2012, and this application claims the benefit of priority of U.S. Provisional Application No. 61/445,401, filed Feb. 22, 2011; these applications are incorporated by reference ...

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Номер записи: 97
22-08-2013 дата публикации

TRIAZINE POLYMER THAT CAN BE USED AS MEMBRANE IN A FUEL CELL

Номер: US20130217851A1
Автор: Delfino Antonio, Fedurco Milan
Принадлежит:

A triazine polymer is provided that can be used as an electrolyte in a PEM fuel cell, and that enables membranes having a high chemical and dimensional stability, as well as a high ion conductivity. The triazine polymer is formed of at least a plurality of base structural units that include a moiety corresponding to a formula (I): 122-. (canceled)26. The triazine polymer according to claim 25 , wherein the perfluorinated hydrocarbon linkage is a perfluoroalkylene of a formula (CF) claim 25 , in which m varies from 1 to 20.27. The triazine polymer according to claim 25 , wherein the perfluorinated hydrocarbon linkage is a perfluorocyclobutylene.28. The triazine polymer according to claim 23 , further comprising additional structural units of a formula (II-A) claim 23 , (II-B) claim 23 , or (II-C):{'br': None, 'sub': 6', '3', '7, '—Ar—X—Ar—\u2003\u2003(II-A)'}{'br': None, 'sub': 8', '4', '2', 'm', '5', '9, '—Ar—X—(CF)—X—Ar—\u2003\u2003(II-B)'}{'br': None, 'sub': 10', '11', '2', 'm', '12', '13, '—Ar—CO—Ar—(CF)—Ar—CO—Ar—\u2003\u2003(II-C)'} [{'sub': 6', '7', '8', '9', '10', '11', '12', '13, 'Ar, Ar, Ar, Ar, Ar, Ar, Arand Ar, which are identical or different, represent a substituted or unsubstituted phenylene group;'}, {'sub': 3', '4', '5', '2, 'X, Xand X, which are identical or different, represent S, SO, or SO; and'}, 'm varies from 1 to 20., 'in which29. The triazine polymer according to claim 23 , wherein at least a portion of the base structural units are connected to one another via bridges chosen from a group that includes: ether (—O—) bonds claim 23 , thioether (—S—) bonds claim 23 , sulphoxide (—SO—) bonds claim 23 , sulphone (—SO—) bonds claim 23 , and mixtures thereof.30. The triazine polymer according to claim 29 , wherein at least a portion of the additional structural units are connected to one another via bridges chosen from a group that includes: ether (—O—) bonds claim 29 , thioether (—S—) bonds claim 29 , sulphoxide (—SO—) bonds claim 29 , sulphone (—SO ...

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Номер записи: 98
29-08-2013 дата публикации

CURABLE RESIN COMPOSITION AND SHORT-CURE METHOD

Номер: US20130225788A1
Автор: MEEGAN Jonathan E.
Принадлежит: CYTEC TECHNOLOGY CORP.

Disclosed herein is a method for utilizing the exothermic energy generated by a low temperature cure reaction to access a high-temperature cure reaction, which is otherwise energetically inaccessible at a chosen tool temperature, thereby producing a cured resin matrix with properties closely matching to those produced via high-temperature cure reactions but achieved via a short cure time and low cure temperature. Also disclosed is a short-cure resin composition containing: (a) at least one multifunctional epoxy resin having an epoxy functionality of greater than 1; (b) a hardener composition containing (i) at least one aliphatic or cycloaliphatic amine curing agent having one or more amino groups per molecule; (ii) at least one aromatic amine curing agent having one or more amino groups per molecule; and optionally, (iii) an imidazole as curing accelerator. The improved properties of this resin composition include being curable at a temperature of ≦120° C. for a time period of less than 10 minutes to achieve a degree of cure higher than that derived from the same composition with just (i) aliphatic/cycloaliphatic amine or (ii) aromatic amine in isolation. 1. A curable epoxy resin composition comprising:(a) at least one multifunctional epoxy resin having an epoxy functionality of greater than 1 and that functionality is based on glydicyl amine, or glycidyl ether, or both; i. at least one aliphatic or cycloaliphatic amine curing agent having one or more amino groups per molecule and capable of curing said at least one multifunctional epoxy resin at a temperature within the range of 30° C-100° C.;', 'ii. at least one aromatic amine curing agent having one or more amino groups per molecule and capable of curing said at least one multifunctional epoxy resin at a temperature of 120° C. or greater;, '(b) a hardener composition comprisingwherein said epoxy resin composition has a cure onset temperature of <50° C. as measured by Differential Scanning calorimetry (DSC) at a ...

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Номер записи: 99
29-08-2013 дата публикации

Crosslinked Polymers with the Crosslinker as Therapeutic for Sustained Release

Номер: US20130225857A1
Автор: Arthur Driscoll, Joshua Kennedy, Phillip Blaskovich, Rachit Ohri, Steven L. Bennett
Принадлежит: Confluent Surgical Inc, COVIDIEN LP

Crosslinked polymers, methods for their preparation and use, are described in which the crosslinked polymers are formed from at least two polymer precursors, one of which is designed, upon degradation of the crosslinked polymer, to release the second polymer precursor in its original, unmodified chemical form.

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Номер записи: 100