Deep eutectic solvent compositions

Process for improving the flow rate of an aqueous dispersion

Process for improving the flow rate of an aqueous dispersion

Process for improving the flow rate of an aqueous dispersion

INORGANICALLY FILLING, FORMED ARTICLES AND PROCEDURES FOR THEIR PRODUCTION

STRENGTH-BOUND ZELLULARE MATRIX

Sizing composition for mineral wool containing a reducing saccharide and a hydrogenated saccharide, and resulting insulating products

The present invention relates to a sizing composition for insulating products containing mineral wool, in particular stone wool or glass wool, which includes: at least one reducing saccharide; at least one hydrogenated saccharide; and at least one polyfunctional cross-linking agent, the hydrogenated saccharide(s) accounting for 10 to 90% of the total weight of reducing saccharide(s) and hydrogenated saccharide(s). The invention also relates to the resulting mineral-fiber insulating products and to the method for manufacturing same.

Biopolymer compositions and products thereof

Cross-linked ethylsulfonated dihydroxypropyl cellulose

The invention provides methods and compositions for improving the production of alumina hydrate. The invention involves adding one or more cross-linked ethylsulfonated polysaccharides to liquor or slurry in the fluid circuit of the production process. The one or more polysaccharides include cross-linked dextran or cross-linked dihydroxypropyl cellulose. The various polysaccharides can impart a number of advantages including at least some of: greater flocculation effectiveness, increasing the maximum effective dosage, faster settling rate. The production process can be a Bayer process.

Process for the preparation of polysaccharide nanoparticles

The process for the preparation of nanoparticles from polysaccharides and derivatives thereof, by their specific partial oxidation to produce aldehyde groups and attach compounds with amino or other group with the R-NH2 bond which react with aldehyde groups, comprising oxidizing the polysaccharide or derivative thereof by a known method to obtain aldehyde groups until the oxidation degree of 0,1% to 80% of the sugar rings is obtained, then adding at least one nanoparticle-forming agent which after attachment of the aldehyde group exhibits hydrophobic properties, selected from the group comprising: aliphatic or aromatic organic amines containing from 4 to 20 carbon atoms, amides and hydrazides of aliphatic and aromatic organic acids containing from 4 to 20 carbon atoms, hydrophobic amino acids, phosphatidylethanolamine, and at least one active substance containing at least one amino, amido or hydrazide group, to the solution of the oxidized polysaccharide in water or a mixture of water and ...

Compositions having a high ungelatinized starch content and sheets molded therefrom

Methods for extruding novel hydraulically settable compositions

H. PYLORI LIPOPOLYSACCHARIDE OUTER CORE EPITOPE

Helicobacter pylori, one of the most common human pathogens, is associated with the development of human chronic gastritis, peptic ulcers and gastric cancer. The invention relates to a .alpha.1,6-glucan-containing Helicobacter pylori compound comprising the structure of Formula (I): wherein R is a .alpha.-DDHep-3-.alpha.-L-Fuc-3-.beta.-G1cNAc trisaccharide substituted with an .alpha.1,6-glucan linked to an .alpha.1,3-DD-heptan, and wherein the last DD-Hep residue of .alpha.1,3-DD- heptan is capped with .beta.-G1cNAc residue. Compositions comprising the compound, uses of the compound, and antibodies raised against the compound are also described.

WASHING AND CLEANING MULTI-LAYER FILMS, METHOD FOR THE PRODUCTION AND USE THEREOF

The present invention relates to a washing and cleaning multi-layer film comprising at least one layer containing a polymer composition or consisting of a polymer composition, obtainable by radical polymerization of a monomer composition which contains at least one a,ß-ethylenically unsaturated carboxylic acid or a salt or an anhydride thereof, wherein the radical polymerization takes place in the presence of at least one polyether component. The invention further relates to a method for producing such a multi-layered film, to the use of such a multi-layered film and to a covering or coating for a washing or cleaning composition portion which comprises such a multi-layered film or consists thereof.

METHODS AND COMPOSITIONS FOR MAINTAINING THE CONFORMATION AND STRUCTURAL INTEGRITY OF BIOMOLECULES

A composition includes a target pharmaceutical or biological agent, a solution containing the target pharmaceutical or biological agent, and substrate that is soluble in the solution. The substrate is capable of being solidified via a solidification process and the solidification process causes the substrate to become physically or chemically cross-linked, vitrified, or crystallized. As a result of the solidification process, particles are formed. The target pharmaceutical or biological agent within the solution retains proper conformation to ultimately produce a desired effect.

GELLING DEXTRAN ETHERS

Compositions are disclosed herein comprising at least one dextran ether compound that comprises uncharged, anionic, and/or cationic organic groups. The degree of substitution of one or more dextran ether compounds is about 0.0025 to about 3Ø Dextran from which the disclosed ether compounds can be derived can have a weight-average molecular weight of about 50-200 million Daltons and/or a z-average radius of gyration of about 200-280 nm. Also disclosed are methods of producing dextran ether compounds, as well as methods of using these ether compounds in various applications.

BIOCOMPATIBLE POLYSACCHARIDE-BASED HYDROGELS

Modified polysaccharides and crosslinked modified polysaccharide compositions are described. Methods of using the crosslinked modified polysaccharide compositions to deliver proteins, oligonucleotides, or pharmaceutical agents are also disclosed.

HYDRAULICALLY SETTABLE CONTAINERS

Containers incorporating a hydraulically settable structural matrix including a hydraulically settable binder such as cement for use in the storing, dispensing, and/or packaging of food and beverage products are disclosed. The disposable and nondisposable food and beverage articles of manufacture have high tensile, compressive, and flexural strengths, and are lightweight, insulative (if desired), inexpensive, and more environmentally compatible than those currently used. These disposable containers and cups are particularly useful for dispensing hot and cold food and beverages in the fast food restaurant environment. The structural matrix of the food and beverage containers includes a hydraulic cement paste (formed from the reaction of water with, e.g., a portland-type cement) preferably in combination with a rheology-modifying plasticizer, such as methylhydroxyethylcellulose, various aggregate materials, and fibrous materials, which provide desired properties at a cost which is economical ...

HIGHLY INORGANICALLY FILLED COMPOSITIONS

Compositions, methods, and apparatus for manufacturing sheets having a highl y inorganically filled matrix prepared by mixing together an organic polymer binder, water, one or more inorganic aggregate materials, fibers, and optional admixtures in the correct proportions in order to form a sheet which has the desired performance criteria. The inorganically filled mixtures are formed into sheets by first extruding the mixtures (40) and then passing the extruded materials between a set of rollers (50). The rolled sheets are dried in an accelerated manner to form a substantially hardened sheet, such as by heated rollers and/or a drying chamber. The inorganically filled sheets may have properties substantially similar to sheets presently made form traditional materials like paper, paperboard, polystyrene, plastic or metal. Such sheets can be rolled, pressed, scored, perforated, folded, and glued. They have particular utility in the mass production of articles, such as food and beverage containers ...

Polysaccharide coating.

Die Erfindung betrifft ein Verfahren zur Beschichtung des Ballons eines Ballonkatheters, wobei die Oberfläche des Ballons zumindest teilweise mit einer ersten Lösung, enthaltend ein Polysaccharid, benetzt wird und der mit der ersten Lösung benetzte Teil der Oberfläche des Ballons mit einer zweiten Lösung benetzt wird, die einen Wirkstoff enthält. Auf diese Weise wird der Ballon mit einer Wirkstoffschicht versehen, die bei der Ballondilatation effektiv auf die Gefässinnenwand appliziert wird und zum anderen eine verzögerte, lang anhaltende Wirkstofffreisetzung bewirkt.

POLYSACCHARIDE COATING

PROCÉDÉ DE FABRICATION D'UNE PAILLE JETABLE, ENTIÈREMENT BIODÉGRADABLE.

L'invention concerne un procédé de fabrication d'une paille jetable, entièrement biodégradable, Une poudre végétale naturelle est préparée. Un gel de konjac désacétylé est préparé. Un mélange amidon de taro - amidon de manioc est réticulé. La matière brute est agitée et mélangée pour obtenir la matière brute mélangée, et la matière brute mélangée est chauffée. La matière brute chauffée est adressée à une unité de fabrication de paille pour boissons pour obtenir un produit brut de paille. Le produit brut de paille est coupé pour obtenir plusieurs pailles. Le contrôle de la qualité, la désinfection et le conditionnement de la paille sont effectués, et la paille entièrement biodégradable est finalement obtenue.

MICELLAR NANOKOMPLEKS

[BIOPOLIMERNYE] COMPOSITIONS AND PRODUCTS ON THEIR BASIS

METHOD OF INCREASING FLOW RATE OF AQUEOUS DISPERSION

SIZING COMPOSITION FOR MINERAL WOOL BASED ON REDUCING SACCHARIDE AND HYDROGENATED SACCHARIDE AND OBTAINED INSULATING PRODUCTS

PARTICLES FORMEES Of a COMPLEX POLYELECTROLYTE OF CHITOSANE AND an ANION POLYSACCHARIDE, PRESENTING a STABILITY AMELIOREE

덱스트란과 그래프트된 가교된 히알루론산

... 가교된 히알루론산과 하나 이상의 덱스트란 분자를 포함하는 히알루론산 생성물. 히알루론산은 에테르 결합에 의해 가교되고, 하나 이상의 덱스트란 분자는 상기 가교된 히알루론산에 공유적으로 그래프트된다.

COMPOSITIONS HAVING RAISED TEXT OF STARCH NOT GELATINIZADO AND LEVES MOLDED OF THE SAME ONES

Proceso para mejorar las propiedades reológicas de una dispersión acuosa

POLYPEPTIDE HAVING THE CAPACITY TO FORM ALPHA-1,3 GLUCOSYL UNIT BRANCHINGS ON AN ACCEPTOR

PHASE SEPARATED COMPOSITE

QUICK-ACTING INSULIN FORMULATION INCLUDING AN OLIGOSACCHARIDE

The invention relates to a composition in an aqueous solution, which includes insulin and at least one oligosaccharide, the mean polymerisation degree of which is from 3 to 13 and the polydispersity index Ip of which is higher than 1.0, said oligosaccharide comprising partially substituted carboxyl functional groups, the non-substituted carboxyl functional groups being salifiable.

PROCESS FOR THE PREPARATION OF POLYSACCHARIDE NANOPARTICLES

The process for the preparation of nanoparticles from polysaccharides and derivatives thereof, by their specific partial oxidation to produce aldehyde groups and attach compounds with amino or other group with the R-NH2 bond which react with aldehyde groups, comprising oxidizing the polysaccharide or derivative thereof by a known method to obtain aldehyde groups until the oxidation degree of 0,1% to 80% of the sugar rings is obtained, then adding at least one nanoparticle-forming agent which after attachment of the aldehyde group exhibits hydrophobic properties, selected from the group comprising: aliphatic or aromatic organic amines containing from 4 to 20 carbon atoms, amides and hydrazides of aliphatic and aromatic organic acids containing from 4 to 20 carbon atoms, hydrophobic amino acids, phosphatidylethanolamine, and at least one active substance containing at least one amino, amido or hydrazide group, to the solution of the oxidized polysaccharide in water or a mixture of water and ...

PHOTOCROSSLINKED HYDROGEL BLEND SURFACE COATINGS

Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.

H. Pylori Lipopolysaccharide Outer Core Epitope

... wherein R is a α-DDHep-3-α-L-Fuc-3-β-GlcNAc trisaccharide substituted with an α1,6-glucan linked to an α1,3-DD-heptan, and wherein the last DD-Hep residue of α1,3-DD-heptan is capped with β-GlcNAc residue. Compositions comprising the compound, uses of the compound, and antibodies raised against the compound are also described.

Hydrogel-forming system with hydrophobic and hydrophilic components

A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxyl groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Preferably, the hydrophobic polymer is prepared by reacting the hydroxyls of a diol obtained by converting hydroxy of terminal carboxylic acid group of poly(lactic acid) to aminoethanol group, with an unsaturated group introducing compound which is acryloyl chloride or isocyanate having an unsaturated group at one end of the molecules. Preferably, the hydrophilic polymer is dextran wherein one or more hydroxyls in a glucose unit of the dextran is (are) reacted with an unsaturated group introducing compound which is acryloyl chloride or isocyanate having an unsaturated group ...

COMPOSITIONS AND METHODS FOR ATMOSPHERIC SPRAY FREEZE DRYING

Methods of preparing dried powders of biologically active compositions are disclosed. They are designed to provide dried material that maintains biological activity at low economic cost. Compositions made by the above methods are also described.

POLYPEPTIDE HAVING THE CAPACITY TO FORM ALPHA-1,3 GLUCOSYL UNIT BRANCHINGS ON AN ACCEPTOR

Polypeptides having the ability to specifically form connections of glucosyl units in alpha 1,3 on an acceptor having at least one hydroxyl moiety are presented. The polypeptides include i) the pattern I of sequence SEQ ID NO: 1, ii) the pattern II of sequence SEQ ID NO: 2, iii) the pattern III of sequence SEQ ID NO: 3, and iv) the pattern IV of sequence SEQ ID NO: 4, or derivates from one or several of said patterns, wherein the polypeptide furthermore has an aspartic residue (D) at position 5 of the pattern II (SEQ ID NO: 2), a glutamic acid residue (E) at position 6 of the pattern III (SEQ ID NO: 3) and an aspartic acid residue (D) at position 6 of the pattern IV (SEQ ID NO: 4). Methods for producing acceptors connected to glucosyl units in alpha 1,3 using the polypeptides are also provided. 1. A method for producing acceptors connected to glucosyl units in alpha 1 ,3 comprising a rate of connections of said glucosyl units in alpha 1 ,3 between 1% and 50% , the method comprising the steps of:(i) mixing in a reaction medium: (i) the pattern I of sequence SEQ ID NO: 1,', '(ii) the pattern II of sequence SEQ ID NO: 2,', '(iii) the pattern III of sequence SEQ ID NO: 3, and', '(iv) the pattern IV of sequence SEQ ID NO: 4,', 'or a derivative of one or more of said domains having at least 80% identity with them, wherein said derivative maintains an aspartic acid residue (D) at position 5 of the pattern II (SEQ ID NO: 2), a glutamic acid residue (E) at position 6 of the pattern III (SEQ ID NO: 3), and an aspartic acid residue (D) at position 6 of the pattern IV (SEQ ID NO: 4);, 'an isolated polypeptide having the ability to specifically form connections of glucosyl units in alpha-1,3 on an acceptor having at least one hydroxyl moiety, said polypeptide comprisinga substrate of said polypeptide; andan acceptor comprising at least one hydroxyl moiety; and 'wherein the rate of connections of such glucosyl units in alpha 1,3 is controlled by varying the ratio between the ...

TISSUE ENHANCEMENT IMPLANT AND METHOD

HYDROGELS FOR DRUG DELIVERY

The invention concerns cross-linked dextran polymer Dx bearing anionic groups wherein the at least divalent radical L(-)i is covalently bound to the dextran polymer backbone with i-W-radicals, wherein, - L(-)i is a linear or branched polyether - i is the valence of L and the number of-W-radicals bound to the dextran polymer and is an integer comprised from 2 to 8 (2 ≤ i ≤ 8), - -W- is a radical comprising at least a radical alkyl linear or branched and optionally comprising heteroatoms such as oxygen, nitrogen or sulfur, aromatic cycles, polyether derivatives and that does not comprise two or more alpha aminoacid residues in particular linked by peptidic bond(s). It also concerns the dextran polymers before the crosslinking reaction and the process to synthetize a cross-linked dextran polymer according to the invention, into the form of a hydrogel. It also concerns a hydrogel comprising the crosslinked dextran polymer of the invention and/or a hydrogel that further comprises an API. It ...

АКТИВНАЯ В ОТНОШЕНИИ МЫТЬЯ И ЧИСТКИ МНОГОСЛОЙНАЯ ПЛЕНКА, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ

УСОВЕРШЕНСТВОВАННАЯ СУХАЯ МАТРИЦА ДЛЯ ВСТРАИВАНИЯ ЖИЗНЕСПОСОБНЫХ ESCHERICHIA COLI, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ЕЕ ИСПОЛЬЗОВАНИЯ

СПОСОБ ПОЛУЧЕНИЯ НАНОЧАСТИЦ ПОЛИСАХАРИДОВ

... 1. Способ получения наночастиц полисахаридов и их производных, их специфического частичного окисления для получения альдегидных групп и прикрепления соединений с аминогруппой или другой группой с R-NH, которые реагируют с альдегидной группой, отличающийся тем, что полисахарид или его производное окисляется с помощью известного способа, чтобы получить альдегидные группы, пока не будет получена степень окисления 0,1% до 80% сахарных цепей, и затем по крайней мере одно нанообразующее вещество, которое после прикрепления альдегидной группы проявляет гидрофобные свойства, выбирают из группы, включающей: алифатические или ароматические органические амины, содержащие от 4 до 20 атомов углерода, амидов и гидразидов алифатических и ароматических органических кислот, содержащие от 4 до 20 атомов углерода, гидрофобных аминокислот, фосфатидилэтаноламин и по меньшей мере одно действующее вещество, содержащее по крайней мере одну амино, амидо или гидразидную группу, добавляется в раствор окисленного ...

HIGHLY CONCENTRATED AQUEOUS SOLUTIONS OF BETAINES

Polysaccharide suspension, process for their preparation and their use

Die vorliegende Erfindung betrifft eine neuartige stabile, kolloidale Polysaccharidsuspension enthaltend a(13)-Glucan, ein wirtschaftliches Verfahren zu ihrer Herstellung und mögliche Anwendungen dieser Polysaccharidsuspensionen.

COMPOSITION AND METHOD FOR PREVENTING OF GLUINGS BETWEEN BODY FABRICS.

ON AND ABSCHWELLENDE POLYMER MIXTURES

Polymer encapsulation of adenoviruses

PHARMACEUTICAL EXCIPIENTS COMPRISING INORGANIC PARTICLES IN ASSOCIATION WITH AN ORGANIC POLYMERIC MATERIAL AND FORMING A SOLID RETICULATED MATRIX, COMPOSITIONS, MANUFACTURING AND USE THEREOF

Vascular prosthesis impregnated with crosslinked dextran

Swelling and deswelling polymer blends

Bioabsorbable surgical composition

BIOABSORBABLE SURGICAL COMPOSITION Bioabsorbable macromer compositions are provided including a polymeric component possessing a lipid segment which enhances the affinity of the macromer composition to targeted tissue. In some embodiments, the polymeric component can be combined with a second component. The resulting bioabsorbable macromer composition can be employed as an adhesive or sealant for medical/surgical uses.

Preparation and/or formulation of proteins cross-linked with polysaccharides

Therapeutic compositions and/or formulations are provided, comprising: at least one cross- linked protein matrix, wherein the at least one cross-linked protein matrix comprises at least one protein residue and at least one saccharide-containing residue, and methods of producing the same. The cross-linked protein matrix may be derived from cross-linking a full length or substantially full length protein, such as tropoelastin, elastin, albumin, collagen, collagen monomers, immunoglobulins, insulin, and/or derivatives or combinations thereof, with a saccharide containing cross-linking agent, such as a polysaccharide cross-linking agent derived from, for example, hyaluronic acid or a cellulose derivative. The therapeutic compositions may be administered topically or by injection. The present disclosure also provides methods, systems, and/or kits for the preparation and/or formulation of the compositions disclosed herein.

Compositions and methods for the removal of sulfates and metals from waste water

The invention is directed to compounds, compositions and methods for the removal of contaminants from fluids and, in particular sulfates and/or metals from industrial waste water. Compounds and compositions of the invention contain polysaccharides and other organic molecules. These flocculating agents are safe and effective, requiring no special handling procedures. Flocculation compounds include biopolymers of dextran, modified dextran and blends of dextrans, plus other organic and/or inorganic molecules. With the addition of flocculants of the invention to waste water, contaminants such as sulfate and toxic heavy metals can be safely, easily and efficiently removed.

Preparation and/or formulation of proteins cross-linked with polysaccharides

Therapeutic compositions and/or formulations are provided, comprising: at least one cross linked protein matrix, wherein the, at least one cross-linked protein matrix comprises at least one protein residue and at least one saccharide-containing residue, and methods of producing the 5 same. The cross-linked protein matrix may be derived from cross-linking a full length or substantially full length protein, such as tropoelastin, elastin, albumin, collagen, collagen monomers, immunoglobulins, insulin, and/or derivatives or combinations thereof, with a saccharide containing cross-linking agent, such as a polysaccharide cross-linking agent derived from, for example, hyaluronic acid or a cellulose derivative. The therapeutic compositions may 0 be administered topically or by injection. The present disclosure also provides methods, systems, and/or kits for the preparation and/or formulation of the compositions disclosed herein.

Crosslinked dextran and crosslinked dextran-poly alpha-1,3-glucan graft copolymers

Compositions are disclosed herein comprising one or more crosslinked dextrans or crosslinked dextran-poly alpha-1,3-glucan graft copolymers. Further disclosed are processes for preparing such crosslinked materials, as well as their use in absorption applications.

Process for improving the rheological properties of an aqueous dispersion

A process for improving the rheological properties of an aqueous dispersion comprising adding a rheology modifier to the aqueous dispersion, and then adding a water soluble synthetic polymer flocculant to the aqueous dispersion. The rheology modifier may be selected from the group consisting of natural polymers, semi-natural polymers, synthetic materials and combinations thereof. The water soluble synthetic polymer flocculant may be selected from the group consisting of water soluble anionic polymers, cationic polymers, amphoteric polymers, nonionic polymers, and combinations thereof.

Novel composition for preparing polysaccharide fibers

This invention pertains to a novel process for preparing fibers from poly((13) glucan). The fibers prepared according to the invention, have"cotton-like" properties, are useful in textile applications, and can be produced as continuous filaments on a year-round basis. The process comprises solution spinning from a novel solution of poly((13) glucan) in a mixture of water and N-methylmorpholine-N-oxide followed by coagulation in a liquid coagulant that comprises a liquid that is not water..

Process for the preparation of polysaccharide nanoparticles

The process for the preparation of nanoparticles from polysaccharides and derivatives thereof, by their specific partial oxidation to produce aldehyde groups and attach compounds with amino or other group with the R-NH2 bond which react with aldehyde groups, comprising oxidizing the polysaccharide or derivative thereof by a known method to obtain aldehyde groups until the oxidation degree of 0,1% to 80% of the sugar rings is obtained, then adding at least one nanoparticle-forming agent which after attachment of the aldehyde group exhibits hydrophobic properties, selected from the group comprising: aliphatic or aromatic organic amines containing from 4 to 20 carbon atoms, amides and hydrazides of aliphatic and aromatic organic acids containing from 4 to 20 carbon atoms, hydrophobic amino acids, phosphatidylethanolamine, and at least one active substance containing at least one amino, amido or hydrazide group, to the solution of the oxidized polysaccharide in water or a mixture of water and ...

PHARMACEUTICAL EXCIPIENTS COMPRISING INORGANIC PARTICLES IN ASSOCIATION WITH AN ORGANIC POLYMERIC MATERIAL AND FORMING A SOLID RETICULATED MATRIX, COMPOSITIONS, MANUFACTURING AND USE THEREOF

A pharmaceutical excipient comprising a solid, reticulated matrix, wherein the matrix comprises an aggregation of inorganic particles in association with an organic polymeric material, defines a plurality of pores with a mean width in the range of about 0.01-500 m, and has a specific surface area of at least about 1 m2/g is described, as are products comprising such excipients, methods of making them and use thereof.

PHOTOCROSSLINKED HYDROGEL BLEND SURFACE COATINGS

Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.

COMPOSITIONS AND METHODS FOR THE REMOVAL OF SULFATES AND METALS FROM WASTE WATER

The invention is directed to compounds, compositions and methods for the removal of contaminants from fluids and, in particular sulfates and/or metals from industrial waste water. Compounds and compositions of the invention contain polysaccharides and other organic molecules. These flocculating agents are safe and effective, requiring no special handling procedures. Flocculation compounds include biopolymers of dextran, modified dextran and blends of dextrans, plus other organic and/or inorganic molecules. With the addition of flocculants of the invention to waste water, contaminants such as sulfate and toxic heavy metals can be safely, easily and efficiently removed.

BIO-BASED BINDERS FOR INSULATION AND NON-WOVEN MATS

An aqueous binder composition is provided that includes a carbohydrate and a crosslinking agent. In exemplary embodiments, the carbohydrate-based binder composition may also include a catalyst, a coupling agent, a process aid, a crosslinking density enhancer, an extender, a moisture resistant agent, a dedusting oil, a colorant, a corrosion inhibitor, a surfactant, a pH adjuster, and combinations thereof. The carbohydrate may be natural in origin and derived from renewable resources. Additionally, the carbohydrate polymer may have a dextrose equivalent (DE) number from 2 to 20. In at least one exemplary embodiment, the carbohydrate is a water-soluble polysaccharide such as dextrin or maltodextrin and the crosslinking agent is citric acid. Advantageously, the carbohydrates have a low viscosity and cure at moderate temperatures. The environmentally friendly, formaldehyde-free binder may be used in the formation of insulation materials and non-woven chopped strand mats. A method of making fibrous ...

BIOCOMPATIBLE POLYSACCHARIDE-BASED HYDROGELS

Modified polysaccharides and crosslinked modified polysaccharide compositions are described. Methods of using the crosslinked modified polysaccharide compositions to deliver proteins, oligonucleotides, or pharmaceutical agents are also disclosed.

CHEMICAL TREATEMENT TO IMPROVE RED MUD SEPARATION AND WASHING IN THE BAYER PROCESS

The invention provides methods and compositions for improving the rheology of red mud removed from Bayer Process liquor. The method includes adding a flocculant and a cross-linked polysaccharide to the liquor. This combination separates the red mud from the liquor but also prevents the red mud from becoming too thick. By preventing excessive thickness, the method allows for the formation of extremely dense amounts of red mud even in primary settlers because the dense red mud can still flow. As a result a user can simultaneously enjoy both easy handling of red mud and also high recovery rates of valuable alumina and caustic from the red mud.

PROCESS FOR IMPROVING THE RHEOLOGICAL PROPERTIES OF AN AQUEOUS DISPERSION

A process for improving the rheological properties of an aqueous dispersion comprising adding a rheology modifier to the aqueous dispersion, and then adding a water soluble synthetic polymer flocculant to the aqueous dispersion. The rheology modifier may be selected from the group consisting of natural polymers, semi-natural polymers, synthetic materials and combinations thereof. The water soluble synthetic polymer flocculant may be selected from the group consisting of water soluble anionic polymers, cationic polymers, amphoteric polymers, nonionic polymers, and combinations thereof.

PREPARATION AND/OR FORMULATION OF PROTEINS CROSS-LINKED WITH POLYSACCHARIDES

Therapeutic compositions and/or formulations are provided, comprising: at least one cross- linked protein matrix, wherein the at least one cross-linked protein matrix comprises at least one protein residue and at least one saccharide-containing residue, and methods of producing the same. The cross-linked protein matrix may be derived from cross-linking a full length or substantially full length protein, such as tropoelastin, elastin, albumin, collagen, collagen monomers, immunoglobulins, insulin, and/or derivatives or combinations thereof, with a saccharide containing cross-linking agent, such as a polysaccharide cross-linking agent derived from, for example, hyaluronic acid or a cellulose derivative. The therapeutic compositions may be administered topically or by injection. The present disclosure also provides methods, systems, and/or kits for the preparation and/or formulation of the compositions disclosed herein.

SIZING COMPOSITION FOR MINERAL WOOL BASED ON REDUCING SACCHARIDE AND HYDROGENATED SACCHARIDE AND RESULTING INSULATING PRODUCTS

NEW DEXTRAN SULFATE

BONDING COMPOSITION FOR MINERAL WOOL BASED ON REDUCING SACCHARIDE AND HYDROGENATED SACCHARIDE, AND INSULATING PRODUCTS OBTAINED

SOLUBLE COMPLEXES POLYSACCHARIDE/BMP-7 HAS PHYSIOLOGICAL PH

... [0001] L'invention concerne un complexe polymère/BMP-7 soluble à pH physiologique, caractérisé en ce que le polymère est choisi dans le groupe des polysaccharides comportant des groupes fonctionnels carboxyles dont un au moins est substitué par au moins un radical hydrophobe, noté Ah, ledit radical hydrophobe Ah étant un reste d'un composé hydrophobe choisi parmi les alcool, thioalcool, acide, O-thioacide ou amine hydrophobes comportant une chaine alkyle linéaire, ramifiée ou cyclique comportant au moins 6 atomes de carbone, résultant soit du couplage entre une de ses fonctions réactives et une fonction carboxyle du polysaccharide anionique soit du couplage entre une de ses fonctions réactives et une fonction réactive du précurseur du bras de liaison R' constitué d'une chaîne comprenant entre 4 et 50 carbones, éventuellement branchée et/ou insaturée, éventuellement comprenant un ou plusieurs hétéroatomes, tels que O, N ou/et S, éventuellement comprenant un ou plusieurs cycles ou hétérocycles ...

Polypeptide Having The Capacity Form Branches Glucosyl Units Alpha -1,3 On UN_AONONBREAKAO> Acceptor

Biodegradable polymer microsphere, polymer filler comprising biodegradable polymer microsphere and method for producing thereof

본 발명은 생분해성 고분자 미립자, 이를 포함하는 고분자 필러 및 이의 제조방법에 관한 것이다. 본 발명에 따른 생분해성 고분자는 생분해성 고분자 미립자 자체의 크기 및 분포도가 균일한 상태로 미립자의 크기는 작고 상대적으로 구형이다. 이러한 이유로 본 발명에 따른 고분자 필러를 가는 주사바늘로 주사주입 하는 것이 가능하여 보다 손쉽게 고분자 필러를 인체에 주입하는 것이 가능하다. 또한 고분자 필러가 인체에 주입된 이후에도 생분해성 고분자 미립자들의 부피 감소율이 작아 그 부피를 지속적으로 유지할 수 있어 시술 후에도 성형 만족도가 아주 높은 효과가 있다.

HYDROGEL PRODUCT COMPRISING POLYION COMPLEX AND METHOD FOR MANUFACTURING SAME

The present invention relates to a hydrogel product which comprises an anionic polymer having an average molecular weight of 100 kDa to 1,000 kDa and dextran substituted with an amine group, wherein the anionic polymer and dextran are grafted and a cationic functional group is complexed to the main chain of the anionic polymer, and a method for manufacturing the same. The hydrogel product is excellent in stability and adhesiveness in a living body while reducing water absorption of the hydrogel itself so as to have a wide range of applications. COPYRIGHT KIPO 2018 ...

PROCESS TO SWELL AND TO REDUCE A SWELLING MIXTURES POLIMÉRICAS

Dextran sulfate having improved biological effects

DEXTRAN SULFATE HAVING IMPROVED BIOLOGICAL EFFECTS ABSTRACT A dextran sulfate, or a salt thereof, has a number average molecular weight (Mn) as measured by NMR spectroscopy within an interval of 1850 and 3500 Da. The dextran sulfate, or the salt thereof, also has an average sulfate number per glucose unit within an interval of 2.5 and 3.0. Furthermore, an average sulfation of C2 position in the glucose units of the dextran sulfate, or the salt thereof, is at least 90 %. The dextran sulfate has improved biological effects and/or reduced toxicity as compared to similar dextran sulfate molecules available on the market. Fig. 10 ...

NOVEL COMPOSITION FOR PREPARING POLYSACCHARIDE FIBERS

Solutions formed by combining poly(α(1→3) glucan) with CS2 in aqueous alkali metal hydroxide solution have been shown to produce the xanthated form of the poly(α(1→3) glucan). The solutions so formed have been shown to be useful for solution spinning into fiber of poly(α(1→3) glucan) when the spun fiber is coagulated in an acidic coagulation bath. The fibers so produced exhibit desirable physical properties. The poly(α(1→3) glucan) employed was synthesized by fermentation.

HINGES FOR HIGHLY INORGANICALLY FILLED COMPOSITE MATERIALS

A hinge for use in inorganically filled composite materials is provided. The hinge has an inorganically filled structural matrix comprising a water-dispersable organic polymer binder, an aggregate material, and a fibrous material. The hinge allows inorganically filled materials to be bent along a line without breakage of the material. The hinge is preferably formed by scoring a formed sheet of inorganically filled material (50). The hinge is particularly useful in containers that require bending of various container parts, such as in food containers and boxes made from inorganically filled materials.

METHODS FOR EXTRUDING NOVEL HYDRAULICALLY SETTABLE COMPOSITIONS

Hydraulically settable mixtures are extruded through auger extruder (20) into a variety of objects which are form-stable in the green state. High green strength is achieved by increasing yield stress of the mixture while maintaining adequate extrudability through first and second auger screws (26, 32) in first and second interior chambers (24, 30). Optimizing particle packing density while including a deficiency of water yields a hydraulically settable mixture which flows under pressures typically associated with extrusion of clay or plastic. A rheology-modifying agent can be added to increase yield stress while not significantly increasing viscosity of the mixture extruded through die head (34). Desired strength properties and other performance criteria of the final hardened extruded product having width and thickness dimensions generally corresponding to die width (38) and die thickness (39) of transverse slit (36), are controlled by adding aggregates, fibers, and other admixtures.

Manufacturing process for polysaccharide beads

The invention discloses a method of manufacturing polysaccharide beads, comprising the steps of: i) providing a water phase comprising an aqueous solution of a polysaccharide; ii) providing an oil phase comprising at least one water-immiscible organic solvent and at least one oil-soluble emulsifier; iii) emulsifying the water phase in the oil phase to form a water-in-oil (w/o) emulsion; and iv) inducing solidification of the water phase in the w/o emulsion, wherein the organic solvent is an aliphatic or alicyclic ketone or ether.

Hydrogel entrapping therapeutic agent and stent with coating comprising this

A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom. In one embodiment, a vascular stent is coated with hydrogel with therapeutic agent entrapped therein.

Process for Improving the Rheological Properties of an Aqueous Dispersion

A process for improving the rheological properties of an aqueous dispersion comprising adding a rheology modifier to the aqueous dispersion, and then adding a water soluble synthetic polymer flocculant to the aqueous dispersion. The rheology modifier may be selected from the group consisting of natural polymers, semi-natural polymers, synthetic materials and combinations thereof. The water soluble synthetic polymer flocculant may be selected from the group consisting of water soluble anionic polymers, cationic polymers, amphoteric polymers, nonionic polymers, and combinations thereof.

ALPHA-1,3-GLUCAN GRAFT COPOLYMERS

Compositions are disclosed herein comprising a graft copolymer that comprises: (i) a backbone comprising dextran that has been modified with about 1%-25% alpha-1,2 branches, and (ii) one or more alpha-1,3-glucan side chains comprising at least about 50% alpha-1,3 glycosidic linkages. Further disclosed are reactions for producing such graft copolymers, as well as their use in derivatives, films and various other applications.

Cutting press

Compositions, methods and system for manufacturing articles, including containers and packaging materials, from inorganically filled materials are disclosed. Suitable compositions are prepared by mixing together an organic binder, water, and appropriate additives (such as aggregates, fibers, and rheology-modifying agents) which impart predetermined properties so that an article formed therefrom has the desired performance criteria. The desired article can be molded from a sheet. The sheet forming processes require the mixture to first be fashioned into a sheet, such as by the use of an extruder or rollers, after which the sheet is formed into the desired article. Once the article is formed, it is hardened. Printed indica and a coating can then be applied.

DUAL-CROSSLINKED HYDROGEL AND PREPARATION METHOD THEREOF

УСОВЕРШЕНСТВОВАННАЯ СУХАЯ МАТРИЦА ДЛЯ ВСТРАИВАНИЯ ЖИЗНЕСПОСОБНЫХ ESCHERICHIA COLI, СПОСОБ ЕЕ ПОЛУЧЕНИЯ И ЕЕ ИСПОЛЬЗОВАНИЯ

Группа изобретений относится к биотехнологии. Предложены матрица, содержащая жизнеспособные непатогенные Escherichia coli, и способ получения матрицы. Матрица представлена в форме частицы, содержащей альгинат и покрытой полисахаридом мальтодекстрином или декстрином и дисахаридом, представленным сахарозой или трегалозой. Способ включает смешиваниес альгинатом с образованием смеси, образование частиц из указанной смеси и контактирование указанных частиц с консервирующим раствором, содержащим сахарозу или трегалозу и мальтодекстрин или декстран; высушивание полученных частиц. Изобретения обеспечивают условия консервирования и хранения для бактерий с сохранением биологической активности. 2 н. и 6 з.п. ф-лы, 22 табл., 14 пр., 10 ил.

ПОПЕРЕЧНО-СШИТАЯ ГИАЛУРОНОВАЯ КИСЛОТА С ПРИВИТЫМ ДЕКСТРАНОМ

NEUES MITTEL ZUR PROPHYLAXE UND THERAPIE VON DEHYDRATATIONEN IN DER VETERINAERMEDIZIN, VERFAHREN ZU DESSEN HERSTELLUNG UND SEINE NEUE ANWENDUNG

SUBSTITUTE FOR AMINO & PHENOLIC RESINS

Method for producing low-cost fully biodegradable disposable straw

Biodegradable disposable straw production comprises pulverizing natural plant material to prepare a powder, pulverizing konjac gel, followed by swelling in water and stirring to obtain a swollen konjac gel. Water and Calcium hydroxide are added and stirred to produce a deacetylated konjac gel. Sodium hydroxide solution is added to a taro starch-cassava starch mixture and mixed, heated and filtered to obtain a taro starch-cassava starch crude product. Water is added to obtain a starch slurry, sodium sulphate added then stirred. The PH of the slurry is adjusted and crosslinker added. The starch slurry is subjected to ultrasonic and microwave treatment in a water bath and PH adjusted again. The slurry is washed with distilled water then dried in an oven and pulverised to obtain a crosslinked taro starch-cassava starch powder. The crosslinked taro starch-cassava starch powder, deacetylated konjac gel, a natural plant powder, a bio-based biodegradable plastic, a stabilizer and a nucleation agent ...

HYDRAULICGEL-FORMING SYSTEM WITH HYDROPHOBEN AND HYDROPHILIC COMPONENTS

Polysaccharide suspension, process for their preparation and their use

Die vorliegende Erfindung betrifft eine neuartige stabile, kolloidale Polysaccharidsuspension enthaltend a(1 ~3)-Giucan, ein wirtschaftliches Verfahren zu ihrer Herstellung und mögliche Anwendungen dieser Polysaccharidsuspensionen.

WITH INTERLACED DEXTRAN CONTAINER PROSTHESIS IMPREGNATED

Vascular prosthesis impregnated with crosslinked dextran

MOLDINGS AND PREPARATION AND USES THEREOF

Compositions and methods for reducing oxidative damage

Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. Methods of preventing oxidative damage to an eye lens of a subject are further provided and include administering the foregoing polymeric compositions to the eye lens of the subject.

Polymers and Hydrogels

Methods and compositions related polymers and hydrogels. In some cases to biodegradable hydrogels for use in medical applications are disclosed. The polymers and hydrogels may be produced from cross-linked dextran and poly(epoxides). The poly(epoxides) may be poloxamers.

Phase separated composite

A composite is disclosed. The composite comprises a first conjugate of a polymer and a first phenol-containing moiety, and a second conjugate of a gelatin or collagen and a second phenol-containing moiety, wherein the polymer is selected so that the first conjugate is less cell-adhesive than the second conjugate, at least one of the first and second conjugates is crosslinked to form a matrix, and the composite comprises discrete regions that are rich in one of said first and second conjugates. A method of forming such composite is also disclosed. The method comprises mixing precursors for the first and second conjugates in a solution for forming said composite, and dispersing a catalyst in the solution to catalyze crosslinking of at least one of the first and second conjugates to form the matrix. The composite may be used to grow cells.

Process for Improving the Flow Rate of an Aqueous Dispersion

A process for improving the flow rate of an aqueous dispersion which comprises adding a natural polymer to said aqueous system and then adding a synthetic polymer to the aqueous system. 1. A process for improving the flow rate of an aqueous dispersion comprising(a) adding a natural polymer to the aqueous dispersion, and(b) then adding a synthetic polymer to the aqueous dispersion, wherein the natural polymer and the synthetic polymer is an amount effective to increase the flow rate of the aqueous dispersion.2. The process of wherein the natural polymer is a polysaccharide.3. The process of wherein the polysaccharide is a dextran.4. The process of wherein the synthetic polymer is selected from the group consisting of water soluble anionic polymers claim 3 , cationic polymers claim 3 , amphoteric polymers claim 3 , nonionic polymers claim 3 , and mixtures thereof.5. The process of wherein the synthetic polymer is an anionic polymer.6. The process of wherein the anionic polymer is selected from the group consisting of copolymers derived from 2-acrylamido 2-methylpropane sulfonic acid claim 5 , copolymers of acrylic acid and acrylamide claim 5 , homopolymers of acrylic acid claim 5 , homopolymers of acrylamide claim 5 , and combinations thereof.7. The process of wherein the anionic polymer comprises a copolymer of sodium acrylate and acrylamide or a copolymer of acrylic acid and acrylamide.8. The process of wherein the pH of the anionic polymer is about 5 to about 10.9. The process of wherein Mw of the dextran is about 5 claim 5 ,000 to about 40 claim 5 ,000 claim 5 ,0000.10. The process of wherein Mw of the anionic polymer is about 500 claim 9 ,000 to about 25 claim 9 ,000 claim 9 ,000.11. The process of wherein the PDI of the dextran is about 1.0 to about 0.12. The process of wherein weight ratio of natural polymer and synthetic polymer is a ratio effective to increase the flow rate of the aqueous dispersion.13. The process of wherein weight ratio of natural polymer ...

Compositions and methods for making alpha-(1,2)-branched alpha-(1,6) oligodextrans

Compositions for improving the health of a subject comprise alpha-(1,2)-branched alpha-(1,6) oligodextrans, preferably with an average molecular weight between about 10 kDa and 70 kDa, between about 10% and 50% alpha-(1,2)-osidic side chains, and having at least partial indigestibility in the subject. Methods for improving the health of a subject comprise administering the composition to a subject in an amount effective to improve gut health, or to prevent or treat a gastrointestinal disorder, a cholesterol-related disorder, diabetes, or obesity. Methods for making oligodextrans having controlled size and controlled degree of branching comprise providing alpha-(1,6) oligodextrans having an average molecular weight between 0.5 and 100 kDa and introducing at least 10% alpha-(1,2)-osidic side chains onto the alpha-(1,6) oligodextrans.

MICELLAR NANOCOMPLEX

The present invention relates to micellar nanocomplexes and a method of forming the same. The micellar nanocomplex comprises a micelle and an agent encapsulated within said micelle, where the micelle comprises a polymer-flavonoid conjugate, wherein said polymer is bonded to the B ring of said flavonoid. The micellar nanocomplex may have useful applications as a drug-delivery system. 124-. (canceled)25. A polymer-flavonoid conjugate comprising a polymer bonded to the B ring of a flavonoid.26. The polymer-flavonoid conjugate of claim 25 , wherein said polymer is selected from the group consisting of a polysaccharide claim 25 , polyacrylamide claim 25 , poly(N-isopropylacrylamide) claim 25 , poly(oxazoline) claim 25 , polyethylenimine claim 25 , poly(acrylic acid) claim 25 , polymethacrylate claim 25 , poly(ethylene glycol) claim 25 , poly(ethylene oxide) claim 25 , poly(vinyl alcohol) claim 25 , poly(vinylpyrrolidinone) claim 25 , polyethers claim 25 , poly(allylamine) claim 25 , polyanhydrides claim 25 , poly(β-amino ester) claim 25 , poly(butylene succinate) claim 25 , polycaprolactone claim 25 , polycarbonate claim 25 , polydioxanone claim 25 , poly(glycerol) claim 25 , polyglycolic acid claim 25 , poly(3-hydroxypropionic acid) claim 25 , poly(2-hydroxyethyl methacrylate) claim 25 , poly(N-(2-hydroxypropyl)methacrylamide) claim 25 , polylactic acid claim 25 , poly(lactic-co-glycolic acid) claim 25 , poly(ortho esters) claim 25 , poly(2-oxazoline) claim 25 , poly(sebacic acid) claim 25 , poly(terephthalate-co-phosphate) and copolymers thereof.27. The polymer-flavonoid conjugate of claim 25 , wherein said flavonoid is selected from the group consisting of (−)-epicatechin claim 25 , (+)-epicatechin claim 25 , (−)-catechin claim 25 , (+)-catechin claim 25 , epicatechin gallate claim 25 , epigallocatechin claim 25 , epigallocatechin gallate claim 25 , Fisetinidol claim 25 , Gallocatechin claim 25 , Gallocatechin gallate claim 25 , Mesquitol and Robinetinidol claim 25 , ...

Use of a Polyanionic Composition

Disclosed herein is a use of a composition, comprising a non-toxic polyanionic material or a salt thereof to dissociate a polymeric membrane. In addition, a method of dissociating a polymeric membrane is also presented, the method comprising the steps of providing a polymeric membrane; and dissociating the polymeric membrane by adding a composition comprising a non-toxic polyanionic material to the polymeric membrane. 1. Use of a composition comprising a non-toxic polyanionic material or a salt thereof to dissociate a polymeric membrane , wherein the non-toxic polyanionic material is a polysaccharide sulfate , a poly(sodium styrene sulfonate) or a polyacrylic acid or a salt thereof , provided that the polysaccharide sulfate is not a glycosoaminoglycan.2. The use of claim 1 , wherein the polymeric membrane is in the form of a capsule that encapsulates a substance or in the form of a barrier that blocks free movement of a substance.3. The use of or claim 1 , wherein the polymeric membrane comprises sodium cellulose sulfate and polydiallyldimethylammonium chloride (pDADMAC).4. The use of or claim 1 , wherein the substance is selected from one or more of the group consisting of cells claim 1 , proteins claim 1 , biocompatible particles claim 1 , and chemical compounds claim 1 , optionally wherein the substance is a plurality of cells.5. The use of any one of the preceding claims claim 1 , wherein the polyanionic material or a salt thereof has a number average molecular weight of from 4 claim 1 ,000 to 20 claim 1 ,000 Daltons claim 1 , optionally from 4 claim 1 ,500 to 15 claim 1 ,000 Daltons (e.g. from 5 claim 1 ,000 to 10 claim 1 ,000 Daltons claim 1 , such as 5 claim 1 ,000 Daltons).6. The use of any one of the preceding claims claim 1 , wherein the polyanionic material or salt thereof is a polysaccharide sulfate claim 1 , optionally wherein each saccharide unit of the polysaccharide sulfate contains from 1 to 3 sulfate groups.7. The use of claim 6 , wherein the ...

Method for producing low-cost fully biodegradable disposable straw

A method for producing a low-cost fully biodegradable disposable straw. Natural plant powder is prepared. Deacetylated konjac gel is prepared. The taro starch-cassava starch is crosslinked. The raw material is stirred and mixed to obtain the mixed raw material, and the mixed raw material is heated. The heated raw material is added to the beverage straw manufacturing unit to obtain a straw crude. The straw crude is cut to obtain several straws. The quality inspection, the disinfection and the packaging of the straw are carried out, and the fully biodegradable straw is obtained, finally.

TARGETED NANOPARTICLES

The invention in the various aspects provides nanogel compositions that are safe for topical, local, and/or systemic delivery, and which can be targeted to select tissues or cells, including pathogens. In some embodiments, conjugation of antibiotics to the nanogel surface, and in particular antibiotics that disrupt outer membranes of Gram negative bacteria or antibiotics that inhibit cell wall synthesis, provide for highly effective targeting and killing of bacterial pathogens, including drug-resistant bacteria. 1. A hydrogel composition , comprising:a population of polymeric nanoparticles having conjugated to their surface polymyxin B and/or Vancomycin.2. The hydrogel composition of claim 1 , wherein the nanoparticles have polymyxin B conjugated to their surface.3. The hydrogel composition of claim 1 , wherein the nanoparticles have vancomycin conjugated to their surface.4. The hydrogel composition of claim 1 , wherein the nanoparticles have polymyxin B and vancomycin conjugated to their surface.5. The hydrogel composition of claim 1 , wherein the nanoparticles comprise cross-linked copolymers.6. The hydrogel composition of claim 5 , wherein at least one co-polymer is a polysaccharide claim 5 , which is either linear claim 5 , cyclic or branched.7. The hydrogel composition of claim 6 , wherein the polysaccharide is a glucan.8. The hydrogel composition of claim 6 , wherein the polysaccharide is at least one of dextran claim 6 , chitosan claim 6 , and cyclodextran.9. The hydrogel composition of claim 5 , wherein at least one co-polymer is selected from polyvinyl alcohol claim 5 , acrylate claim 5 , and polyacrylate.1040.-. (canceled)41. A hydrogel preparation comprising nanoparticles of dextran cross-linked with poloxamer claim 5 , and having surface conjugated antibiotic that disrupts outer membrane of gram negative bacteria claim 5 , or inhibits cell wall synthesis of gram positive or gram negative bacteria.42. The hydrogel composition of claim 41 , wherein the ...

CORROSION INHIBITOR COMPOSITION AND METHODS OF INHIBITING CORROSION DURING ACID PICKLING

A corrosion inhibitor composition, which includes i) an aqueous alcohol base fluid, ii) a mixture of at least three polysaccharides selected from carboxymethyl cellulose, gum arabic, pectin, a salt of alginic acid, chitosan, dextran, hydroxyethyl cellulose, and soluble starch, with each polysaccharide that is present in the mixture being present in an amount of 0.05 to 0.5 wt. %, based on a total weight of the corrosion inhibitor composition, iii) silver nanoparticles, and iv) a pineapple leaves extract. A method of inhibiting corrosion of metal during acid cleaning/pickling whereby the metal is treated with an acidic treatment fluid containing an acid and the corrosion inhibitor composition. 1. A corrosion inhibitor composition , comprising:a base fluid comprising water and an alcohol;a mixture of at least three polysaccharides selected from the group consisting of carboxymethyl cellulose, gum arabic, pectin, a salt of alginic acid, chitosan, dextran, hydroxyethyl cellulose, and soluble starch, with each polysaccharide that is present in the mixture being present in an amount of 0.05 to 0.5 wt. %, based on a total weight of the corrosion inhibitor composition;silver nanoparticles; anda pineapple leaves extract.2. The corrosion inhibitor composition of claim 1 , wherein the alcohol is a monoalcohol.3. The corrosion inhibitor composition of claim 1 , wherein the alcohol is isopropanol.4. The corrosion inhibitor composition of claim 1 , wherein a ratio of water to the alcohol by volume is 2:1 to 1:2.5. The corrosion inhibitor composition of claim 1 , wherein three polysaccharides are present in the mixture.6. The corrosion inhibitor composition of claim 5 , wherein each of the three polysaccharides is present in an amount of 30 to 40 wt. % claim 5 , based on a total weight of the mixture.7. The corrosion inhibitor composition of claim 1 , wherein the mixture consists of carboxymethyl cellulose claim 1 , gum arabic claim 1 , and pectin.8. The corrosion inhibitor ...

Methods and Compositions for Maintaining the Conformation and Structural Integrity of Biomolecules

A liquid ink composition includes a liquid phase and particles suspended in the liquid phase, the particles containing a target pharmaceutical or biological agent. The biological activity of the target pharmaceutical or biological agent is preserved upon suspension of the particles in the liquid phase. The liquid phase is capable of solidifying via a solidification process. 1. A liquid ink composition comprising:a liquid phase andparticles suspended in the liquid phase, the particles containing a pharmaceutical or biological agent,wherein the biological activity of the pharmaceutical or biological agent is preserved upon suspension of the particles in the liquid phase,wherein the liquid phase is capable of solidifying to form three dimensional structures.2. The liquid ink composition of claim 1 , the particles being formed by a process comprising: a pharmaceutical or a biological agent; and', 'a substrate that is soluble in the solution, comprising one or more chemical species;, 'preparing a solution, formed from water as a solvent, comprisingcombining the solution with an oil phase to form a water-in-oil emulsion in which the solution is dispersed in the oil phase;lyophilizing the emulsion,wherein the particles are formed prior to or simultaneously with the lyophilizing,wherein the pharmaceutical or biological agent is entrapped by the formed particles,wherein the substrate composition and the oil phase are selected so that the particles formed are suspendable in the liquid ink composition and the biological activity of the pharmaceutical or biological agent is preserved upon suspension of the particles in the liquid ink composition, andwherein one or more substances selected from the group consisting of a surfactant, a stabilizer, an emulsifier, and combinations thereof are incorporated as part of the substrate.3. The liquid ink composition of claim 1 , wherein the biological activity of the pharmaceutical or biological agent is preserved upon solidification of ...

POLYSACCHARIDE COATING

The invention relates to a method for coating the balloon of a balloon catheter, wherein the surface of the balloon is wetted at least partially with a first solution containing a polysaccharide and the part of the surface of the balloon wetted with the first solution is wetted with a second solution containing an active agent. In this way, the balloon is provided with an active agent layer which is effectively applied to the inner wall of the vessel when the balloon is inflated and moreover results in a delayed long-lasting release of the active agent. 1. Method for coating the balloon of a balloon catheter , wherein the surface of the balloon is at least partially wetted with a first solution containing a polysaccharide , characterized in that the part of the surface of the balloon wetted with the first solution is wetted with at least one second solution containing an active substance.2. Method according to claim 1 , characterized in that the part of the surface of the balloon wetted with the active substance is again wetted with a further liquid containing water and/or at least one alcohol.3. Method according to claim 2 , characterized in that the water and/or at least one alcohol containing liquid contains one alcohol and/or one ketone.4. Method according to claim 2 , characterized in that the concentration of the alcohol and/or ketone in the liquid ranges between 10 and 70% (v/v) claim 2 , preferably between 30 and 65% (v/v) claim 2 , further preferred between 50 and 60% (v/v).5. Method according to claim 3 , characterized in that the liquid contains ethanol claim 3 , methanol claim 3 , acetone and/or isopropanol.6. Method according to claim 1 , characterized in that the first and/or the second solution contains one or several alcohols.7. Method according to claim 6 , characterized in that the concentration of the alcohol in water in the first and/or second solution ranges between 10 and 70% (v/v) claim 6 , preferably between 30 and 65% (v/v) claim 6 , further ...

Methods for Producing High Toughness Silk Fibres

The present invention provides methods for producing a silk protein spinning dope solution suitable for producing high toughness fibres, the thus produced silk protein spinning dope solution, methods for producing fibres using said silk protein spinning dope solution. 1. Method for producing a silk protein spinning dope solution comprising the steps:(a) providing an aqueous solution comprising at least one silk protein and a protein denaturant or mixture of protein denaturants at a silk protein denaturing concentration, wherein the total concentration of the silk protein(s) in the solution is less than 20% w/v;(b) reducing the concentration of the protein denaturant by 8-fold to 14-fold;(c) reducing the concentration of the protein denaturant by 1.5 to 3-fold; and(d) producing the silk protein spinning dope solution by concentrating the silk protein(s) in the solution at least 1.5-fold in comparison to its (their) concentration in step (a) to a concentration of at least 10% w/v.2. The method of claim 1 , wherein the silk protein is a spider silk protein claim 1 , insect silk protein claim 1 , or mussel byssus silk protein or a variant thereof.3. The method of claim 2 , wherein the silk protein or variant thereof has a molecular weight of at least 20 kDa and comprises at least two repetitive units each comprising at least one consensus sequence selected from the group consisting of:(a) GPGXX (SEQ ID NO: 3), wherein X is in each case independently selected from the A, S, G, Y, P, and Q;(b) GGX, wherein X is in each case independently selected from Y, P, R, S, A, T, N and Q; and{'sub': 'x', '(c) A, wherein x is an integer from 5 to 10.'}4. The method of claim 3 , wherein the repetitive units are independently selected from module A (SEQ ID NO: 20) claim 3 , module C (SEQ ID NO: 21) claim 3 , module Q (SEQ ID NO: 22) claim 3 , module S (SEQ ID NO: 25) claim 3 , module R (SEQ ID NO: 26) claim 3 , or variants thereof.5. The method of claim 1 , wherein the silk protein ...

MOLDED ARTICLE COMPRISING POLYSACCHARIDE

Molded articles are disclosed herein, the molded article comprising a polysaccharide, wherein the polysaccharide comprises i) poly alpha-1,3-glucan; ii) poly alpha-1,3-1,6-glucan; iii) a graft copolymer that comprises (A) a backbone comprising dextran with a weight-average molecular weight (Mw) of at least about 100000 Daltons, and (B) poly alpha-1,3-glucan side chains comprising at least about 95% alpha-1,3-glucosidic linkages; or iv) a composition comprising a poly alpha-1,3-glucan ester compound as disclosed herein. Optionally, the molded articles can further comprise a plasticizer and/or starch. The molded articles can be useful as a container, a handle, packaging, a tray, a bottle, a cup, a sheet, a disposable food packaging item, an automotive part, a casing for an electronic device, or a toy. 2. The molded article of claim 1 , wherein the polysaccharide comprises poly alpha-1 claim 1 ,3-glucan.3. The molded article of claim 1 , wherein the polysaccharide comprises poly alpha-1 claim 1 ,3-1 claim 1 ,6-glucan.4. The molded article of claim 1 , wherein the polysaccharide comprises a graft copolymer that comprises:(A) a backbone comprising dextran with a weight-average molecular weight (Mw) of at least about 100000 Daltons, and(B) poly alpha-1,3-glucan side chains comprising at least about 95% alpha-1,3-glucosidic linkages.6. The molded article of claim 1 , wherein the article comprises from about 60 weight percent to about 100 weight percent polysaccharide claim 1 , based on the total weight of the article.7. The molded article of claim 1 , further comprising starch.8. The molded article of claim 1 , further comprising a plasticizer.9. The molded article of claim 8 , wherein the article comprises from about 1 weight percent to about 60 weight percent plasticizer claim 8 , based on the total weight of the article.10. The molded article of claim 8 , wherein the plasticizer comprises fructose claim 8 , sorbitol claim 8 , sucrose claim 8 , glycerol claim 8 , ...

GELLING DEXTRAN ETHERS

Compositions are disclosed herein comprising at least one dextran ether compound that comprises uncharged, anionic, and/or cationic organic groups. The degree of substitution of one or more dextran ether compounds is about 0.0025 to about 3.0. Dextran from which the disclosed ether compounds can be derived can have a weight-average molecular weight of about 50-200 million Daltons and/or a z-average radius of gyration of about 200-280 nm. Also disclosed are methods of producing dextran ether compounds, as well as methods of using these ether compounds in various applications. 115-. (canceled)16. A composition comprising a dextran compound , wherein the dextran compound is a product of an isolated glucosyltransferase enzyme comprising an amino acid sequence that is at least 90% identical to SEQ ID NO:1 or SEQ ID NO:2 , and wherein the weight-average molecular weight (Mw) of said dextran compound is 50 million to 200 million Daltons.17. The composition of claim 16 , wherein the z-average radius of gyration of the dextran compound is 200-280 nm.18. The composition of claim 16 , wherein the dextran compound comprises chains linked together within a branching structure claim 16 , wherein said chains are similar in length and comprise substantially alpha-1 claim 16 ,6-glucosidic linkages.19. The composition of claim 18 , wherein the average length of the chains is 10-50 monomeric units.20. The composition of claim 16 , wherein the dextran compound comprises:(i) 87-91.5 wt % glucose linked at positions 1 and 6;(ii) 0.1-1.2 wt % glucose linked at positions 1 and 3;(iii) 0.1-0.7 wt % glucose linked at positions 1 and 4;(iv) 7.7-8.6 wt % glucose linked at positions 1, 3 and 6; and (a) positions 1, 2 and 6, or', '(b) positions 1, 4 and 6., '(v) 0.4-1.7 wt % glucose linked at21. The composition of claim 20 , wherein the dextran compound comprises:(i) 89.5-90.5 wt % glucose linked at positions 1 and 6;(ii) 0.4-0.9 wt % glucose linked at positions 1 and 3;(iii) 0.3-0.5 wt % ...

Polymeric Carriers and Methods

Provided are methods of controlling disassociation of cells from a carrier, compositions, and methods of collecting cells. The methods of controlling disassociation of cells from a carrier may include contacting a polymeric carrier with one or more digesting agents to disassociate at least a portion of a plurality of cells from the polymeric carrier. The polymeric carrier may be crosslinked with a crosslinker including at least one of a redox sensitive moiety, a UV light sensitive moiety, a pH sensitive moiety, and a temperature sensitive moiety. 1. A method of controlling disassociation of cells from a carrier , the method comprising:providing a polymeric carrier and a plurality of cells adhered to the polymeric carrier; andcontacting the polymeric carrier with one or more digesting agents to disassociate at least a portion of the plurality of cells from the polymeric carrier;wherein the polymeric carrier is crosslinked with a crosslinker comprising at least one redox sensitive moiety.2. The method of claim 1 , wherein the at least one redox sensitive moiety comprises a disulfide bond.13. A method of controlling disassociation of cells from a carrier claim 1 , the method comprising:providing a polymeric carrier and a plurality of cells adhered to the polymeric carrier; andcontacting the polymeric carrier with one or more digesting agents to disassociate at least a portion of the plurality of cells from the polymeric carrier;wherein the polymeric carrier is crosslinked with a crosslinker comprising at least one of a UV light sensitive moiety, a pH sensitive moiety, and a temperature sensitive moiety.14. The method of claim 13 , wherein the crosslinker comprises the UV light sensitive moiety claim 13 , and the UV light sensitive moiety is a photoreversibly dimerizable moiety or a photocleavable moiety.19. The method of claim 14 , wherein the crosslinker comprises the photocleavable moiety claim 14 , and the photocleavable moiety comprises an o-nitrobezene based ...

Pullulan-containing powder, method for producing the same and use thereof

The present invention aims to provide a particulate composition containing pullulan, which can be produced without employing any complicated purification step such as solvent precipitation and, when formed into a film, exhibits a higher rupture strength compared to conventional ones; a process for producing the same; and uses thereof. The present invention solves the above object by providing a particulate composition containing pullulan which is produced from a culture obtained by culturing a mutant of a microorganism of the species Aureobasidium pullulans in a culture medium containing glucose and maltose as carbon sources, without employing a step of removing concomitant saccharides; contains a pullulan fraction and a concomitant saccharide fraction that are respectively insoluble and soluble in 75% by volume of methanol in water; has a percentage of 3% by weight or lower of the content of concomitant saccharides contained in the concomitant saccharide fraction against the content of total saccharides contained in the whole particulate composition, when determined based on the anthrone sulfuric acid method; and contains mannitol; and by providing the process of the same and uses thereof.

Biodegradable material and method for preparing the same

A biodegradable material and a method for preparing a biodegradable material are provided. The biodegradable material includes a continuous phase and a dispersed phase. The continuous phase includes a polyester, and the dispersed phase includes a modified saccharide oligomer. In particular, the weight ratio of the modified saccharide oligomer to the polyester is from 3:97 to 30:70. The dispersed phase has a maximum diameter of 100 nm to 900 nm.

Polysaccharide-Polyamine Copolymers For Removal Of Phosphate

Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated. 1. A polysaccharide-polyamine copolymer having an amino functionality which will provide a protonatable copolymeric material having a three-dimensional structure with cationic sites through protonation , the polysaccharide-polyamine copolymer comprising:a selectively oxidized polysaccharide having a 2,3-dialdehyde moiety; andamino polymers which provide an amino functionality, the amino polymers cross linking the oxidized polysaccharides to provide a particulate polysaccharide-polyamine copolymer having an amino functionality which when protonated will provide the cationic copolymeric material with a nitrogen content of at least 12.3 wt. %, both the polysaccharide-polyamine copolymer and cationic copolymeric material being water insoluble.2. The polysaccharide-polyamine copolymer of claim 1 , wherein the amino polymers have a nitrogen content of at least 24.5 wt. % claim 1 , based on the weight of the amino polymers and a molecular weight in the range of from about 15 claim 1 ,000 to about 900 claim 1 ,000.3. The polysaccharide-polyamine copolymer of claim 1 , wherein the selectively oxidized polysaccharide are selected from the group consisting of selectively oxidized cellulose claim 1 , selectively oxidized starch claim 1 , selectively oxidized amylose claim 1 , selectively oxidized chitosan claim 1 , selectively oxidized dextran claim 1 , selectively oxidized glycogen claim 1 , selectively oxidized chitin and mixtures thereof claim 1 , the polysaccharide having been oxidized in an amount effective to provide ...

COMPOSITIONS AND METHODS FOR MAKING ALPHA-(1,2)-BRANCHED ALPHA-(1,6) OLIGODEXTRANS

Compositions for improving the health of a subject comprise alpha-(1,2)-branched alpha-(1,6) oligodextrans, preferably with an average molecular weight between about 10 kDa and 70 kDa, between about 10% and 50% alpha-(1,2)-osidic side chains, and having at least partial indigestibility in the subject. Methods for improving the health of a subject comprise administering the composition to a subject in an amount effective to improve gut health, or to prevent or treat a gastrointestinal disorder, a cholesterol-related disorder, diabetes, or obesity. Methods for making oligodextrans having controlled size and controlled degree of branching comprise providing alpha-(1,6) oligodextrans having an average molecular weight between 0.5 and 100 kDa and introducing at least 10% alpha-(1,2)-osidic side chains onto the alpha-(1,6) oligodextrans. 1. A composition for improving the health of a subject comprising an alpha-(1 ,2)-branched alpha-(1 ,6) oligodextran.2. The composition of claim 1 , wherein said oligodextran is a prebiotic compound.3. The composition of claim 1 , wherein said oligodextran comprises at least 10% alpha-(1 claim 1 ,2)-osidic side chains.4. The composition of claim 1 , wherein said oligodextran comprises a substantially linear backbone comprising at least two alpha-D-glucopyranosyl units linked by alpha-(1 claim 1 ,6)-linkages.5. The composition of claim 4 , wherein said backbone comprises at least 90% alpha-(1 claim 4 ,6)-D-glucopyranosidic linkages.6. The composition of claim 4 , wherein said backbone has an average molecular weight between about 0.5 kDa and 100 kDa.7. The composition of claim 4 , wherein said backbone has an average molecular weight between about 10 kDa and 70 kDa and said oligodextran comprises between about 10% and 50% alpha-(1 claim 4 ,2)-osidic side chains.8. The composition of claim 1 , wherein said oligodextran comprises less than 10% alpha-(1 claim 1 ,4)-linkages.9. A method for improving the health of a subject comprising ...

BIO-BASED BINDERS FOR INSULATION AND NON-WOVEN MATS

An aqueous binder composition is provided that includes a carbohydrate and a crosslinking agent. In exemplary embodiments, the carbohydrate-based binder composition may also include a catalyst, a coupling agent, a process aid, a crosslinking density enhancer, an extender, a moisture resistant agent, a dedusting oil, a colorant, a corrosion inhibitor, a surfactant, a pH adjuster, and combinations thereof. The carbohydrate may be natural in origin and derived from renewable resources. Additionally, the carbohydrate polymer may have a dextrose equivalent (DE) number from 2 to 20. In at least one exemplary embodiment, the carbohydrate is a water-soluble polysaccharide such as dextrin or maltodextrin and the crosslinking agent is citric acid. Advantageously, the carbohydrates have a low viscosity and cure at moderate temperatures. The environmentally friendly, formaldehyde-free binder may be used in the formation of insulation materials and non-woven chopped strand mats. A method of making fibrous insulation products is also provided. 1. An aqueous binder composition comprising:from 40% to 95% by weight of maltodextrin having a dextrose equivalent number from 2 to 14, and a number average molecular weight of from 1,000 to 8,000; andfrom 5% to 40% by weight of a single crosslinking agent, the single crosslinking agent selected from polycarboxylic acids, salts of polycarboxylic acid, anhydrides, citric acid, salts of citric acid, adipic acid, salts of adipic acid, polyacrylic acid, salts of polyacrylic acid, and polyacrylic acid based resins;wherein the aqueous binder composition is devoid of additional crosslinking agents,wherein the binder composition has a pH of from 1 to 2.5, andwherein the weight percentages are based upon the weight of total solids of the binder composition.2. The binder composition of claim 1 , wherein the single crosslinking agent is selected from the group consisting of citric acid claim 1 , salts of citric acid claim 1 , polyacrylic acid claim 1 ...

Antimicrobial crosslinked polymers containing biomass derived materials

Novel, crosslinked polymers using biomass derived materials, such as aldaric acids and derivatives, are provided. The polymers can be used as hydrogels and in antimicrobial compositions.

Conductive film and display device comprising the same

The present disclosure relates to a conductive film and a display device including the conductive film, and. More specifically, as the conductive film includes a conductive polymer layer and a plurality of metal nanowires and includes a network structure inserted in the conductive polymer layer, it is possible to provide the conductive film with high light transmittance and excellent electrical conductivity and the display device including the conductive film.

OXIDIZED DEXTRAN

Compositions comprising oxidized dextran compounds are disclosed herein. Oxidized dextran compounds are produced by contacting dextran under aqueous conditions with at least one N-oxoammonium salt, at least one periodate compound, and/or at least one peroxide compound. 115-. (canceled)16. A composition comprising an oxidized dextran compound , wherein the oxidized dextran compound is produced by contacting dextran under aqueous conditions with at least one N-oxoammonium salt , at least one periodate compound , and/or at least one peroxide compound ,wherein the dextran is a product of an isolated glucosyltransferase enzyme comprising an amino acid sequence that is at least 90% identical to SEQ ID NO:1 or SEQ ID NO:2, and wherein the weight-average molecular weight of said dextran is 50 million to 200 million Daltons.17. The composition of claim 16 , wherein the z-average radius of gyration of the dextran compound is 200-280 nm.18. The composition of claim 16 , wherein the dextran is contacted with the periodate compound.19. The composition of claim 16 , wherein the dextran is first contacted with the periodate compound claim 16 , and then contacted with the N-oxoammonium salt.20. The composition of claim 16 , wherein the N-oxoammonium salt comprises a TEMPO oxoammonium salt.21. The composition of claim 16 , wherein the composition is a personal care product claim 16 , industrial product claim 16 , pharmaceutical product claim 16 , or food product.22. The composition of claim 16 , wherein the composition is a household product.23. The composition of claim 16 , wherein the composition is a detergent composition.24. The composition of claim 16 , wherein the composition is a fabric care product.25. The composition of claim 16 , wherein the composition is a dishwashing detergent composition.26. The composition of claim 25 , wherein the dishwashing detergent composition is an automatic dishwashing detergent composition.27. The composition of claim 25 , wherein the ...

RUBBER COMPOSITIONS COMPRISING POLYSACCHARIDES

Compositions are disclosed herein comprising a rubber component and a polysaccharide, wherein the polysaccharide comprises i) poly alpha-1,3-glucan; ii) poly alpha-1,3-1,6-glucan; iii) water insoluble alpha-(1,3-glucan) polymer having 90% or greater α-1,3-glycosidic linkages, less than 1% by weight of alpha-1,3,6-glycosidic branch points, and a number average degree of polymerization in the range of from 55 to 10,000; iv) dextran; v) a composition comprising poly alpha-1,3-glucan ester compounds as disclosed herein; or vi) water-insoluble cellulose having a weight-average degree of polymerization (DPw) of about 10 to about 1000 and a cellulose II crystal structure. The compositions can be used in articles such as a tire, a belt, a seal, footwear, a coating, a film, or an adhesive. 2. The rubber composition of claim 1 , wherein the rubber component comprises at least one diene-based sulfur-vulcanizable elastomer having a Tg below −30° C. claim 1 , as determined by dynamic mechanical analysis.3. The rubber composition of claim 2 , wherein the elastomer comprises natural rubber claim 2 , synthetic polyisoprene claim 2 , styrene butadiene copolymer rubber claim 2 , ethylene propylene diene monomer rubber claim 2 , hydrogenated nitrile butadiene rubber claim 2 , polybutadiene claim 2 , silicone rubber claim 2 , or neoprene.4. The rubber composition of claim 1 , wherein the polysaccharide comprises poly alpha-1 claim 1 ,3-glucan.5. The rubber composition of claim 1 , wherein the polysaccharide comprises poly alpha-1 claim 1 ,3-1 claim 1 ,6-glucan.6. The rubber composition of claim 1 , wherein the polysaccharide comprises dextran.8. The rubber composition of claim 7 , wherein the poly alpha-1 claim 7 ,3-glucan ester compound comprises poly alpha-1 claim 7 ,3-glucan succinate claim 7 , poly alpha-1 claim 7 ,3-glucan methylsuccinate claim 7 , poly alpha-1 claim 7 ,3-glucan 2-methylene succinate claim 7 , poly alpha-1 claim 7 ,3-glucan maleate claim 7 , poly alpha-1 claim 7 , ...

Fiberglass insulation product

A fibrous insulation product having a plurality of randomly oriented glass fibers and a binder composition that holds the glass fibers together is disclosed. The fibrous insulation product has an R-value in the range of 10 to 54 and, after curing, has a density, when uncompressed, in the range of 0.30 pcf to 2.7 pcf. Furthermore, the fibrous insulation product includes glass fibers that, prior to the application of the binder composition, have an average fiber diameter less than 15 HT and a quantity of binder that is in the range of 2% to 10% by weight of the fibrous insulation product. The fibrous insulation product also has an average fiber diameter to density ratio (Fd/D) of less than or equal to 40 and a comfort factor less than or equal to 3.417(Fd/D)+60.

Very high molar mass dextrans

The subject matter of the invention is dextrans which have between 95% and 99% of α-1,6 glucosidic bonds, a weight-average molar mass M w at least equal to 0.7×10 9 g.mol −1 , and a dispersity index D of between 1.3 and 3. The invention also relates to a dextran saccharase which makes it possible to produce such dextrans, and to a method for producing said dextrans.

Aqueous compositions of polyaldehydes from the oxidation of polysaccharides and their thermosets

The present invention provides thermosetting aqueous binder compositions comprising a diprimary amine or poly(primary amine) and one or more water soluble oxidized dextrin made by oxidizing a dextrin having a DE value of from 2 to 25 and having from 2 to 10 millieq CHO/g of dry oxidized dextrin or a larger oxidized dextrin or an oxidized dextrin made by oxidizing a dextrin having a DE value of below 2 and having from 0.25 to 5 millieq CHO/g of dry oxidized dextrin. The aqueous biobased binders provide hot wet tensile strength when heat cured.

Controllably Degradable Compositions and Methods

Methods for treating, adhering, or sealing biological tissue are provided. The methods include combining solutions containing a polymer component and a dendrimer component capable of reacting with each other, and at least one of the components includes a substituent capable of photoreversible dimerization that can be reversibly dimerized. Drug delivery compositions and kits containing these two components also are provided. 1. A kit for making an adhesive comprising:a first part which includes a first solution comprising a polymer component, wherein the polymer component comprises a polymer; anda second part which includes a second solution comprising a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups;wherein at least one of the polymer and the dendrimer is substituted with one or more substituents capable of photoreversible dimerization.2. The kit of claim 1 , further comprising a UV light source to activate or deactivate the one or more substituents capable of photoreversible dimerization.3. The kit of claim 1 , wherein less than 75% of the surface groups comprise at least one primary or secondary amine.4. The kit of claim 1 , wherein 100% of the surface groups comprise at least one primary or secondary amine.5. The kit of claim 1 , wherein the polymer comprises dextran.6. The kit of claim 1 , wherein the dendrimer comprises a G5 PAMAM dendrimer.7. The kit of claim 1 , further comprising an applicator.8. The kit of claim 7 , wherein the applicator comprises a multi-compartment syringe.9. The kit of claim 8 , wherein the multi-compartment syringe comprises a mixing tip.10. The kit of claim 1 , wherein the polymer and the dendrimer are substituted with the one or more substituents capable of photoreversible dimerization.11. A drug delivery composition comprising:a polymer component, wherein the polymer component comprises a polymer having three or more aldehyde groups;a dendrimer ...

Compositions and Methods for the Removal of Sulfates and Metals From Waste Water

The invention is directed to compounds, compositions and methods for the removal of contaminants from fluids and, in particular sulfates and/or metals from industrial waste water. Compounds and compositions of the invention contain polysaccharides and other organic molecules. These flocculating agents are safe and effective, requiring no special handling procedures. Flocculation compounds include biopolymers of dextran, modified dextran and blends of dextrans, plus other organic and/or inorganic molecules. With the addition of flocculants of the invention to waste water, contaminants such as sulfate and toxic heavy metals can be safely, easily and efficiently removed. 1. A flocculant comprising a polymer and a humic acid , wherein the polymer comprises a polysaccharide.2. The flocculant of claim 1 , wherein the polysaccharide comprises dextran claim 1 , guar gum claim 1 , scleroglucan claim 1 , welan claim 1 , xanthan gum claim 1 , schizophyllan claim 1 , pullulan claim 1 , levan claim 1 , cellulose claim 1 , modified polysaccharides claim 1 , blends of polysaccharides claim 1 , and/or combinations thereof.3. The flocculant of claim 2 , wherein the modified polysaccharide comprises dextran sulfate claim 2 , dextran phosphate claim 2 , acidified dextran and/or combinations thereof.4. The flocculant of claim 1 , wherein the polysaccharide contains one or more acidic groups.5. The flocculant of claim 4 , wherein the one or more acidic groups comprises at least one diacid group.6. The flocculant of claim 4 , wherein the one or more acidic groups contain one or more carbon linkers.7. The flocculant of claim 1 , wherein the polymer contains substitutions of one or more monomers of the polymer.8. The flocculant of claim 7 , which contains substitutions of up to 100 percent of the monomers.9. The flocculant of claim 1 , further comprising one or more inorganic salts.10. The flocculant of claim 9 , wherein the one or more inorganic salts comprises calcium oxide claim 9 , ...

Compositions and methods for atmospheric spray freeze drying

Methods of preparing dried powders of biologically active compositions are disclosed. They are designed to provide dried material that maintains biological activity at low economic cost. Compositions made by the above methods are also described.

Use of a Polyanionic Composition

Disclosed herein is a use of a composition, comprising a non-toxic polyanionic material or a salt thereof to dissociate a polymeric membrane. In addition, a method of dissociating a polymeric membrane is also presented, the method comprising the steps of providing a polymeric membrane; and dissociating the polymeric membrane by adding a composition comprising a non-toxic polyanionic material to the polymeric membrane. 1. A composition comprising a non-toxic polyanionic material or a salt thereof and a polymeric membrane , wherein the non-toxic polyanionic material is a polysaccharide sulfate , a poly(sodium styrene sulfonate) or a polyacrylic acid or a salt thereof , provided that the polysaccharide sulfate is not a glycosoaminoglycan.2. The composition of claim 1 , wherein the polymeric membrane is a capsule that encapsulates a substance or is a barrier that blocks free movement of a substance.3. The composition of claim 1 , wherein the polymeric membrane comprises sodium cellulose sulfate and polydiallyldimethylammonium chloride (pDADMAC).4. The composition of claim 2 , wherein the substance is selected from one or more of a member of the group consisting of cells claim 2 , proteins claim 2 , biocompatible particles claim 2 , and chemical compounds.5. The composition of claim 1 , wherein the polyanionic material or a salt thereof has a number average molecular weight of from 4 claim 1 ,000 to 20 claim 1 ,000 Daltons.6. The composition of claim 1 , wherein the polyanionic material or salt thereof is a polysaccharide sulfate.7. The composition of claim 6 , wherein the polysaccharide sulfate is one or more of a member of the group consisting of dextran sulfate and cellulose sulfate with a number average molecular weight of from 4 claim 6 ,000 to 20 claim 6 ,000 Daltons and salts thereof.8. The composition of claim 1 , wherein the non-toxic polyanionic material or a salt thereof is an anti-clumping agent comprising dextran sulfate.9. The composition of claim 1 , ...

POLYPEPTIDES CAPABLE OF PRODUCING GLUCANS HAVING ALPHA (1-->2) LINKAGES AND USE OF THE SAME

Disclosed herein are proteins capable of forming glucans having alpha-1,2 linkages/branches, reactions and methods for producing such glucan, compositions comprising such glucan, and various applications thereof. 117-. (canceled)18. A composition comprising an ether derivative of an alpha-glucan , wherein the alpha-glucan comprises (i) a backbone and (ii) one or more alpha-1 ,2 linkages that branch from the backbone ,wherein at least 70% of the glycosidic linkages of the backbone are alpha-1,6 linkages.19. The composition of claim 18 , wherein at least 80% of the glycosidic linkages of the backbone are alpha-1 claim 18 ,6 linkages.20. The composition of claim 18 , wherein at least 90% of the glycosidic linkages of the backbone are alpha-1 claim 18 ,6 linkages.21. The composition of claim 18 , wherein 100% of the glycosidic linkages of the backbone are alpha-1 claim 18 ,6 linkages.22. The composition of claim 18 , wherein the backbone has a degree of polymerization of 3 to 2000.23. The composition of claim 22 , wherein the degree of polymerization is 10 to 2000.24. The composition of claim 22 , wherein the degree of polymerization is 10 to 1300.25. The composition of claim 22 , wherein the degree of polymerization is 1100 to 1400.26. The composition of claim 22 , wherein the degree of polymerization is 1200 to 1300.27. The composition of claim 22 , wherein the degree of polymerization is 10 to 150.28. The composition of claim 18 , wherein the backbone has a degree of polymerization of at least 10.29. The composition of claim 18 , wherein the alpha-glucan has about 1% to 45% alpha-1 claim 18 ,2 branching.30. The composition of claim 18 , wherein the alpha-glucan has about 3% to 40% alpha-1 claim 18 ,2 branching.31. The composition of claim 18 , wherein the alpha-glucan has about 3% to 20% alpha-1 claim 18 ,2 branching.32. The composition of claim 18 , wherein the alpha-glucan has about 1% to 10% alpha-1 claim 18 ,2 branching.33. The composition of claim 18 , wherein ...

MALTO-DEXTRIN COMPOSITION WITH LOW DE VALUE AND LOW VISCOSITY AND METHOD FOR MAKING THE SAME

A malto-dextrin composition with low DE value and low viscosity and the method for making the same is provided. The malto-dextrin comprises a blue value in the range of 0.02 to 0.28; a dextrose equivalent (DE) in the range of 3 to 10; and a viscosity lower than 26.3185*DE{circumflex over ( )}(−0.7593). The method for preparing the malto-dextrin composition comprises: dispersing raw starch in water to obtain a starch-water slurry; preheating the starch-water slurry with a jet-cooker for a first duration at a first temperature above 100° C. having a temperature variation no more than 0.8° C.; hydrolyzing the slurry by treating the slurry with α-amylases for a second duration at a second temperature; and filtering the hydrolyzed slurry to remove insoluble residual proteins and fibers and obtain an un-fractionated malto-dextrin composition. 1. A malto-dextrin composition , comprises:a blue value in the range of 0.02 to 0.28;a dextrose equivalent (DE) in the range of 3 to 10; anda viscosity lower than 26.3185*DE{circumflex over ( )}(−0.7593).2. The malto-dextrin composition of claim 1 , wherein the viscosity is lower than 26.3185*DE{circumflex over ( )}(−0.7593) by at least 5%.3. The malto-dextrin composition of claim 1 , wherein the viscosity is in the range of 6.0 to 10.0 when the DE value is about 3.4. The malto-dextrin composition of claim 1 , wherein the viscosity is in the range of 5.5 to 8.5 when the DE value is about 4.5. The malto-dextrin composition of claim 1 , wherein the viscosity is in the range of 5.0 to 7.5 when the DE value is about 5.6. The malto-dextrin composition of claim 1 , wherein the viscosity is in the range of 4.75 to 6.5 when the DE value is about 6.7. The malto-dextrin composition of claim 1 , wherein the viscosity is in the range of 4.5 to 5.5 when the DE value is about 7.8. The malto-dextrin composition of claim 1 , wherein the viscosity is in the range of 4.25 to 5.25 when the DE value is about 8.9. The malto-dextrin composition of claim 1 ...

MODIFIED-DEXTRANS FOR USE IN OPTICAL GLUCOSE ASSAYS

The invention is directed to a competitive glucose binding affinity assay comprising a glucose receptor (typically mannan binding lectin) labeled with an assay fluorophore and a modified glucose analog (typically dextran) labeled with a reference fluorophore. In certain embodiments, the glucose analog is dextran and is coupled to both a reference fluorophore and a quencher dye (e.g. hexamethoxy crystalviolet-1). Optionally the reference fluorophore is blue shifted relative to the assay fluorophore. 1. A method of sensing glucose in a solution comprising: mannan binding ligand, wherein the mannan binding ligand is coupled to an assay fluorophore;', 'a reference fluorophore;', 'dextran, wherein the dextran functions in the assay as a glucose analog and is coupled to:', 'the reference fluorophore; and', 'an agent that enhances the hydrophilicity of the dextran; and', 'a quenching agent, wherein the assay fluorophore and quenching agent form a Förster Resonance Energy Transfer (FRET) pair;, '(a) contacting the solution with a glucose sensing complex comprising(b) observing the glucose sensing complex for signals indicative of the presence of glucose; and(c) correlating observed signals with the concentration of glucose.2. The method of claim 1 , wherein the solution comprises interstitial fluid or blood.3. The method of claim 1 , wherein the glucose sensing complex is disposed in vivo.4. The method of claim 1 , wherein the agent that enhances the hydrophilicity of the dextran is the quenching agent.5. The method of claim 1 , wherein the quenching agent is hexamethoxy crystal violet-1 (HMCV1).6. The method of claim 1 , wherein the dextran is modified by an agent selected to enhance its hydrophilicity.8. The method of claim 7 , wherein the agent that enhances the hydrophilicity of the dextran is the quenching agent.9. The method of claim 8 , wherein the quenching agent is hexamethoxy crystal violet-1 (HMCV1).10. The method of claim 7 , wherein the reference fluorophore is ...

RUBBER COMPOSITIONS COMPRISING POLYSACCHARIDES

Compositions are disclosed herein comprising a rubber component and a polysaccharide, wherein the polysaccharide comprises i) poly alpha-1,3-glucan; ii) poly alpha-1,3-1,6-glucan; iii) water insoluble alpha-(1,3-glucan) polymer having 90% or greater α-1,3-glycosidic linkages, less than 1% by weight of alpha-1,3,6-glycosidic branch points, and a number average degree of polymerization in the range of from 55 to 10,000; iv) dextran; v) a composition comprising poly alpha-1,3-glucan ester compounds as disclosed herein; or vi) water-insoluble cellulose having a weight-average degree of polymerization (DPw) of about 10 to about 1000 and a cellulose II crystal structure. The compositions can be used in articles such as a tire, a belt, a seal, footwear, a coating, a film, or an adhesive. 2. The rubber composition of claim 1 , wherein the rubber component comprises at least one diene-based sulfur-vulcanizable elastomer having a Tg below −30° C. claim 1 , as determined by dynamic mechanical analysis.3. The rubber composition of claim 2 , wherein the elastomer comprises natural rubber claim 2 , synthetic polyisoprene claim 2 , styrene butadiene copolymer rubber claim 2 , ethylene propylene diene monomer rubber claim 2 , hydrogenated nitrile butadiene rubber claim 2 , polybutadiene claim 2 , silicone rubber claim 2 , or neoprene.4. The rubber composition of claim 1 , wherein the polysaccharide comprises poly alpha-1 claim 1 ,3-glucan.5. The rubber composition of claim 1 , wherein the polysaccharide comprises poly alpha-1 claim 1 ,3-1 claim 1 ,6-glucan.6. The rubber composition of claim 1 , wherein the polysaccharide comprises dextran.8. The rubber composition of claim 7 , wherein the poly alpha-1 claim 7 ,3-glucan ester compound comprises poly alpha-1 claim 7 ,3-glucan succinate claim 7 , poly alpha-1 claim 7 ,3-glucan methylsuccinate claim 7 , poly alpha-1 claim 7 ,3-glucan 2-methylene succinate claim 7 , poly alpha-1 claim 7 ,3-glucan maleate claim 7 , poly alpha-1 claim 7 , ...

Controllably Degradable Compositions and Methods

Methods, compositions, kits, and drug delivery devices are provided for treating, adhering, or sealing biological tissues. The methods include combining a first solution that includes an oligomer/polymer component and a second solution that includes a dendrimer component, and at least one of the oligomer/polymer component and dendrimer component includes at least one substituent that is capable of photoreversible dimerization. The reversible dimerization of the substituent may allow for the reversible dimerization and/or polymerization of one or more components. The substituent that is capable of photoreversible dimerization may be active by the application of light, such as UV light. 1. A method for treating , adhering , or sealing biological tissue , the method comprising:providing a first solution comprising a polymer component having three or more aldehyde groups, wherein the polymer component comprises two or more oligomer units substituted with one or more first substituents capable of photoreversible dimerization, wherein the one or more first substituents capable of photoreversible dimerization are dimerized;providing a second solution comprising a dendrimer component, wherein the dendrimer component comprises a dendrimer having at least 2 branches with one or more surface groups;combining the first and second solutions together to produce an adhesive formulation and contacting one or more biological tissues with the adhesive formulation; andallowing the adhesive formulation to cure in contact with the one or more biological tissues.2. The method of claim 1 , wherein the dendrimer is substituted with one or more second substituents capable of photoreversible dimerization.3. The method of claim 2 , wherein the first and second substituents capable of photoreversible dimerization are the same.4. The method of claim 2 , further comprising contacting the adhesive formulation with light having a wavelength sufficient to dimerize the second substituent capable of ...

Production of poly alpha-1,3-glucan films

An extrusion process for making a poly alpha-1,3-glucan film is disclosed. These films can be translucent and used in packaging applications.

Orthodontic composite and method for preparing same

Disclosed is an orthodontic composite, comprising: an orthodontic member which has a tube shape, a hollow polygonal prism shape, a hollow truncated polygonal pyramid shape, a hollow truncated cone shape, or a funnel shape; and an orthodontic wire that is inserted into the hollow portion of the orthodontic member, wherein the orthodontic member includes a water-soluble or biodegradable material. Thereby, the orthodontic composite of the present invention making it simple to perform orthodontic treatment by attaching the orthodontic composite.

Preparation and/or Formulation of Proteins Cross-Linked with Polysaccharides

Therapeutic compositions and/or formulations are provided, comprising: at least one cross-linked protein matrix, wherein the at least one cross-linked protein matrix comprises at least one protein residue and at least one saccharide-containing residue, and methods of producing the same. The cross-linked protein matrix may be derived from cross-linking a full length or substantially full length protein, such as tropoelastin, elastin, albumin, collagen, collagen monomers, immunoglobulins, insulin, and/or derivatives or combinations thereof, with a saccharide containing cross-linking agent, such as a polysaccharide cross-linking agent derived from, for example, hyaluronic acid or a cellulose derivative. The therapeutic compositions may be administered topically or by injection. The present disclosure also provides methods, systems, and/or kits for the preparation and/or formulation of the compositions disclosed herein.

DRY MATRIX FOR EMBEDDING VIABLE ESCHERICHIA COLI, METHOD OF MAKING SAME AND USE THEREOF

There is provided viable () embedded in a matrix, wherein said matrix has a water activity (a)≤0.3, and wherein said matrix comprises a hydrocolloid-forming polysaccharide, a second polysaccharide which is different from the first polysaccharide, and a disaccharide which includes sucrose, trehalose, or a combination thereof. There is also provided methods of making same and use thereof. 127-. (canceled)28Escherichia coliE. coliE. coli. A method for protecting viability of () during a drying process , the method comprising: forming particles comprising the embedded in alginate , and a preservation solution including maltodextrin or dextran , and sucrose or trehalose , wherein the drying process includes drying said particles to obtain a water activity (a) of ≤0.3.29. The method of claim 28 , wherein said forming particles comprises:{'i': 'E. coli', 'mixing said with the alginate to form a mixture;'}forming the particles from the mixture; andcontacting the particles with the preservation solution.30. The method of claim 28 , wherein said preservation solution includes a ratio of the sucrose or trehalose/maltodextrin or dextran of less than 10 claim 28 , wherein the ratio is wt. %/wt. %.31. The method of claim 30 , wherein the ratio is of less than 5.32. The method of claim 30 , wherein the ratio is of about 1.33. The method of claim 28 , wherein said particles further comprise a salt of L-glutamic acid.34. The method of claim 33 , wherein said salt is sodium salt of L-glutamic acid.35Escherichia coliE. coliE. coli. A method for increasing viability of () in a dry state claim 33 , the method comprising: forming particles comprising the embedded in alginate claim 33 , and a preservation solution including maltodextrin or dextran claim 33 , and sucrose or trehalose claim 33 , and drying said particles to obtain a water activity (a) of ≤0.3.36. The method of claim 35 , wherein said drying is performed to obtain 0.04≤a≤0.3.37. The method of claim 35 , wherein said forming ...

Polysaccharides for viscosity modification

Compositions are disclosed herein comprising poly alpha-1,3-1,6-glucan with a weight average degree of polymerization (DP w ) of at least 1000. This glucan polymer comprises at least 30% alpha-1,3 linkages and at least 30% alpha-1,6 linkages. Further disclosed are glucosyltransferase enzymes that synthesize poly alpha-1,3-1,6-glucan. Ether derivatives of poly alpha-1,3-1,6-glucan and methods of using such derivatives as viscosity modifiers are also disclosed.

Polysaccharide suspension, method for its preparation, and use thereof

The present invention relates to a novel stable colloidal polysaccharide suspension containing α(1→3)-glucan, a cost-effective method for its preparation, and possible uses of these polysaccharide suspensions.

GELLING DEXTRAN ETHERS

Compositions are disclosed herein comprising at least one dextran ether compound that comprises uncharged, anionic, and/or cationic organic groups. The degree of substitution of one or more dextran ether compounds is about 0.0025 to about 3.0. Dextran from which the disclosed ether compounds can be derived can have a weight-average molecular weight of about 50-200 million Daltons and/or a z-average radius of gyration of about 200-280 nm. Also disclosed are methods of producing dextran ether compounds, as well as methods of using these ether compounds in various applications. 1. A composition comprising a dextran ether compound , wherein the dextran ether compound comprises:(i) about 87-93 wt % glucose linked at positions 1 and 6;(ii) about 0.1-1.2 wt % glucose linked at positions 1 and 3;(iii) about 0.1-0.7 wt % glucose linked at positions 1 and 4;(iv) about 7.7-8.6 wt % glucose linked at positions 1, 3 and 6; (a) positions 1, 2 and 6, or', '(b) positions 1, 4 and 6;, '(v) about 0.4-1.7 wt % glucose linked atand(vi) a degree of substitution (DoS) with at least one organic group of about 0.0025 to about 3.0;wherein the weight-average molecular weight (Mw) of said dextran ether compound is about 50-200 million Daltons.2. The composition of claim 1 , wherein the dextran ether compound comprises:(i) about 89.5-90.5 wt % glucose linked at positions 1 and 6;(ii) about 0.4-0.9 wt % glucose linked at positions 1 and 3;(iii) about 0.3-0.5 wt % glucose linked at positions 1 and 4;(iv) about 8.0-8.3 wt % glucose linked at positions 1, 3 and 6; and (a) positions 1, 2 and 6, or', '(b) positions 1, 4 and 6., '(v) about 0.7-1.4 wt % glucose linked at3. The composition of claim 1 , wherein the dextran ether compound comprises chains linked together within a branching structure claim 1 , wherein said chains are similar in length and comprise substantially alpha-1 claim 1 ,6-glucosidic linkages.4. The composition of claim 3 , wherein the average length of the chains is about 10-50 ...

METHOD OF USING WATER ERODIBLE MARINE ANTIFOULING COATING

A method is described for inhibiting marine fouling on a surface. The surface is contacted with a composition comprising a waterborne polyurethane that is crosslinked with an acrylic acid functionalized polysaccharide, water, and a preservative. The composition is then dried to form a deposited film. The polysaccharide may be xanthan. 1. A method of inhibiting marine fouling of a surface , the method comprising: a waterborne polyurethane (WBPU) crosslinked with an acrylic acid functionalized polysaccharide;', 'water; and', 'a preservative dispersed in the crosslinked WBPU, and, 'contacting the surface with a composition to produce a coated surface, the composition comprisingdrying the coated surface to produce a treated surface having a deposited film.2. The method of claim 1 , wherein the acrylic acid functionalized polysaccharide is present in the deposited film at a weight percentage of 0.1-5.0 wt % relative to a total weight of the deposited film.3. The method of claim 1 , wherein the polysaccharide is at least one selected from the group consisting of xanthan claim 1 , beta-glucan claim 1 , dextran claim 1 , inulin claim 1 , galactan claim 1 , glycogen claim 1 , hemicellulose claim 1 , levan claim 1 , lignin claim 1 , mannan claim 1 , pectin claim 1 , amylopectin claim 1 , and amylose.4. The method of claim 1 , wherein the acrylic acid functionalized polysaccharide comprises 1-50 wt % acrylic acid functional groups relative to a total weight of the acrylic acid functionalized polysaccharide.5. The method of claim 1 , wherein the polysaccharide is xanthan.6. The method of claim 1 , wherein the composition comprises 50-90 wt % water relative to a total weight of the composition.7. The method of claim 1 , wherein the preservative is present at a weight percentage of 0.01-2.0 wt % relative to a total weight of the composition.8. The method of claim 1 , wherein the composition further comprises a pigment.9. The method of claim 1 , wherein the composition consists of ...

Cross-linked hyaluronic acid grafted with dextran

A hyaluronic acid product is comprising a cross-linked hyaluronic acid and one or more dextran molecules. The hyaluronic acid is cross-linked by ether bonds, and the one or more dextran molecules are covalently grafted to the cross-linked hyaluronic acid.

DRY MATRIX FOR EMBEDDING VIABLE ESCHERICHIA COLI, METHOD OF MAKING SAME AND USE THEREOF

There is provided viable () embedded in a matrix, wherein said matrix has a water activity (a)≤0.3, and wherein said matrix comprises a hydrocolloid-forming polysaccharide, a second polysaccharide which is different from the first polysaccharide, and a disaccharide which includes sucrose, trehalose, or a combination thereof. There is also provided methods of making same and use thereof. 1. A particle comprising:{'i': Escherichia coli', 'E. coli', 'E. coli, 'a first composition including a first polysaccharide in the form of a matrix and a viable (), wherein the viable is embedded in the matrix, and wherein the first polysaccharide is a hydrocolloid-forming polysaccharide, and'}a second composition free of the first polysaccharide, the second composition including a second polysaccharide and a disaccharide,{'sub': 'w', 'wherein the particle has a water activity (a)≤0.3.'}2. The particle of claim 1 , wherein the first polysaccharide includes alginate.3. The particle of claim 1 , wherein 0.04≤a≤0.3.4. The particle of claim 1 , wherein said second composition comprises a ratio disaccharide/second polysaccharide of less than 10 claim 1 , wherein the ratio is wt. %/wt. %.5. The particle of claim 4 , wherein the ratio is of less than 5.6. The particle of claim 4 , wherein the ratio is of about 1.7. The particle of claim 1 , wherein said second composition further comprises a salt of L-glutamic acid.8. The particle of claim 7 , wherein said salt is sodium salt of L-glutamic acid.9. The particle of claim 1 , wherein said second polysaccharide includes maltodextrin.10. The particle of claim 1 , wherein said second polysaccharide includes dextran.11E. coliE. coli.. The particle of claim 1 , wherein said includes a non-pathogenic12E. coli. The particle of claim 1 , wherein said non-pathogenic includes the strain deposited at the International Depository Authority of Canada (IDAC) on Jan. 21 claim 1 , 2005 claim 1 , under accession number IDAC 210105-01.13E. coli. The particle ...

PREPARATION AND/OR FORMULATION OF PROTEINS CROSS-LINKED WITH POLYSACCHARIDES

Therapeutic compositions and/or formulations are provided, comprising: at least one cross-linked protein matrix, wherein the at least one cross-linked protein matrix comprises at least one protein residue and at least one saccharide-containing residue, and methods of producing the same. The cross-linked protein matrix may be derived from cross-linking a full length or substantially full length protein, such as tropoelastin, elastin, albumin, collagen, collagen monomers, immunoglobulins, insulin, and/or derivatives or combinations thereof, with a saccharide containing cross-linking agent, such as a polysaccharide cross-linking agent derived from, for example, hyaluronic acid or a cellulose derivative. The therapeutic compositions may be administered topically or by injection. The present disclosure also provides methods, systems, and/or kits for the preparation and/or formulation of the compositions disclosed herein. 1. A kit comprising:(a) a prefilled syringe, wherein the prefilled syringe is filled with a tissue compatible composition comprising a protein selected from the group consisting of tropoelastin and albumin; a hyaluronic acid cross-linking molecule comprising one or more carboxyl groups; and at least one intermolecular cross-linkage comprising an amide bond between an amine of the protein and a carboxyl group of the hyaluronic acid cross-linking molecule; and(b) instructions for use.2. The kit of claim 1 , further comprising an assortment of appropriate sized needles.3. The kit of claim 2 , wherein the assortment of appropriately sized needles comprise fine gauge needles.4. The kit of claim 3 , wherein the needles range from about 25 gauge to about 31 gauge.5. The kit of claim 2 , wherein the needles range from about 18 gauge to about 31 gauge.6. The kit of claim 1 , further comprising a needle delivery system.7. The kit of claim 6 , wherein the needle delivery system is selected from a needle roller ball type system claim 6 , an automatic injection pen ...

INJECTABLE MACROPOROUS HYDROGELS

The inventions relates to a method for generating a macroporous hydrogel. In a first step, an aqueous solution of two solutes is produced. The first solute is a polymer that can be cross-linked and is a derivative of polyethylene glycol (PEG) or polyoxazoline (POx) and the second solute is a kosmotropic agent. In a second step, a cross-linking agent is added to the solution. This simultaneously initiates gelation of the polymer and phase-separation, thus creating a macroporous hydrogel. The invention further relates to a macroporous hydrogel, which can be obtained by the inventive method. This macroporous hydrogel is comprised of a cross-linked polymer, which is a derivative of polyethylene glycol (PEG) or polyoxazoline (POx). The hydrogel exhibits interconnected macropores with a size of 200 nm to 1000 μm, particularly 500 nm to 100 μm and is characterized by a pH of of 7.0 to 8.0, particularly approx. 7.4. 1. A method for providing a macroporous hydrogel , comprising the steps of i) the first solute is a cross-linkable polymer selected from a cross-linkable derivative of a polyethylene glycol (PEG) and a cross-linkable derivative of a polyoxazoline (POx); and', 'ii) the second solute is a kosmotropic agent; and, 'a) providing an aqueous solution comprising a first and a second solute, wherein'}b) adding to said mixture a cross-linking reagent able to cross-link said cross-linkable polymer, thus simultaneously initiating gelation of said cross-linkable polymer and phase-separation.2. The method according to claim 1 , wherein said cross-linkable polymer is selected froma) the group comprising a linear or star-shaped polyethylene glycol, a polyethylene glycol diblock copolymer and a polyethylene glycol triblock copolymer, particularly a polyethylene glycol diblock or three block copolymer wherein >50% of the polymer is constituted of PEG and the rest is constituted of polylactide-co-glycolide (PLGA), poly-s-caprolactone (PCL) and/or polypropylene glycol (PPG); orb) ...

LOW SWEEL TISSUE ADHESIVE AND SEALANT FORMULATIONS

A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized dextran containing pendant aldehyde groups with a multi-arm polyethylene glycol amine is described. The hydrogel exhibits little to no swell upon exposure to physiological conditions. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a low swell hydrogel to inhibit complications, such as fibrosis, including scar formation or surgical adhesions. 1. A kit for forming a low swell hydrogel comprising:(a) a first aqueous solution or dispersion comprising one or more aldehyde-functionalized dextrans containing pendant aldehyde groups, said aldehyde-functionalized dextrans having a weight-average molecular weight of about 10,000 to about 20,000 Daltons and an equivalent weight per aldehyde group of about 226 to about 170; and wherein', '(i) the total concentration of the aldehyde-functionalized dextrans containing pendant aldehyde groups in the first aqueous solution or dispersion is about 5 wt % to about 20 wt % and the total concentration of the polyethylene glycols in the second aqueous solution or dispersion is about 10 wt % to about 18 wt %; or', '(ii) the total concentration of the aldehyde-functionalized dextrans containing pendant aldehyde groups in the first aqueous solution or dispersion is about 5 wt % to about 10 wt % and the total concentration of the polyethylene glycols in the second aqueous solution or dispersion is about 10 wt % to about 20 wt %., '(b) a second aqueous solution or dispersion comprising one or more polyethylene glycols having eight arms, substantially each arm of which is terminated with at least one primary amine group, wherein the polyethylene glycols have a number-average molecular weight of about 9,000 to about 11,000 Daltons;'}2. The kit of claim 1 , wherein the aldehyde-functionalized dextrans have an equivalent weight per aldehyde group of about 226 to about 185.3. The kit of claim 1 , wherein the total ...

LOW SWEEL TISSUE ADHESIVE AND SEALANT FORMULATIONS

A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized dextran containing pendant aldehyde groups with a multi-arm polyethylene glycol amine is described. The hydrogel exhibits little to no swell upon exposure to physiological conditions. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a low swell hydro gel to inhibit complications, such as fibrosis, including scar formation or surgical adhesions. 1. A kit for forming a low swell hydrogel comprising:(a) a first aqueous solution or dispersion comprising one or more aldehyde-functionalized dextrans containing pendant aldehyde groups, said aldehyde-functionalized dextrans having a weight-average molecular weight of about 10,000 to about 20,000 Daltons and an equivalent weight per aldehyde group of about 226 to about 170; and(b) a second aqueous solution or dispersion comprising one or more polyethylene glycols having eight arms, substantially each arm of which is terminated with at least one primary amine group, wherein the polyethylene glycols have a number-average molecular weight of about 9,000 to about 11,000 Daltons; (i) the total concentration of the aldehyde-functionalized dextrans containing pendant aldehyde groups in the first aqueous solution or dispersion is about 5 wt % to about 20 wt % and the total concentration of the polyethylene glycols in the second aqueous solution or dispersion is about 10 wt % to about 18 wt %; or', '(ii) the total concentration of the aldehyde-functionalized dextrans containing pendant aldehyde groups in the first aqueous solution or dispersion is about 5 wt % to about 10 wt % and the total concentration of the polyethylene glycols in the second aqueous solution or dispersion is about 10 wt % to about 20 wt %., 'wherein'}2. The kit of claim 1 , wherein the aldehyde-functionalized dextrans have an equivalent weight per aldehyde group of about 226 to about 185.3. The kit of claim 1 , wherein the total concentration ...

Methods for Producing High Toughness Silk Fibres

The present invention provides methods for producing a silk protein spinning dope solution suitable for producing high toughness fibres, the thus produced silk protein spinning dope solution, methods for producing fibres using said silk protein spinning dope solution. 1. Method for producing a silk protein spinning dope solution comprising the steps:(a) providing an aqueous solution comprising at least one silk protein and a protein denaturant or mixture of protein denaturants at a silk protein denaturing concentration, wherein the total concentration of the silk protein(s) in the solution is less than 20% w/v;(b) reducing the concentration of the protein denaturant by 8-fold to 14-fold;(c) reducing the concentration of the protein denaturant by 1.5 to 3-fold; and(d) producing the silk protein spinning dope solution by concentrating the silk protein(s) in the solution at least 1.5-fold in comparison to its(their) concentration in step (a) to a concentration of at least 10% w/v.2. The method of claim 1 , wherein the silk protein is a spider silk protein claim 1 , preferably a dragline or flagelliform protein of an orb-web spider (Araneidae); insect silk protein claim 1 , or mussel byssus silk protein or a variant thereof.3. (canceled)4. The method of claim 2 , wherein the silk protein or variant thereof has a molecular weight of at least 20 kDa and comprises at least two repetitive units each comprising at least one consensus sequence selected from the group consisting of:(a) GPGXX (SEQ ID NO: 3), wherein X is any amino acid, preferably in each case independently selected from the A, S, G, Y, P, and Q;(b) GGX, wherein X is any amino acid, preferably in each case independently selected from Y, P, R, S, A, T, N and Q; and{'sub': 'x', '(c) A, wherein x is an integer from 5 to 10.'}5. The method of claim 4 , wherein the repetitive units are independently selected from module A (SEQ ID NO: 20) claim 4 , module C (SEQ ID NO: 21) claim 4 , module Q (SEQ ID NO: 22) claim 4 , ...

POLYPEPTIDES CAPABLE OF PRODUCING GLUCANS HAVING ALPHA-1,2 BRANCHES AND USE OF THE SAME

Disclosed herein are proteins capable of forming glucans having alpha-1,2 linkages/branches, reactions and methods for producing such glucan, compositions comprising such glucan, and various applications thereof. 1. A reaction composition comprising at least water , sucrose , an alpha-glucan substrate , and a polypeptide that is capable of forming at least one alpha-1 ,2 branch from the alpha-glucan substrate , wherein the polypeptide comprises an amino acid sequence that is at least 90% identical to:(i) the mature form of a sequence selected from the group consisting of SEQ TD NOs:4, 1, 2, 3, 5, 6, 7, 8, 9, 10, 11, 12, and 13;(ii) SEQ ID NO:27 or a sub-sequence within any one of SEQ ID NOs:4, 2, 3, 5, 6, 7, 8, 9, 10, 11, 12, or 13 that aligns with SEQ ID NO:27; and/or(iii) a sequence selected from the group consisting of SEQ IO NOs:4, 1, 2, 3, 5, 6, 7, 8, 9, 10, 11, 12, and 13.2. The reaction composition of claim 1 , wherein the sequence of (i) comprises:positions 36 to 1672 of SEQ ID NO:4, positions 21 to 2771 of SEQ ID NO:1,positions 21 to 2821 of SEQ m NO:2, positions 41 to 2844 of SEQ ID NO:3,positions 51 to 1632 of SEQ ID NO:5, positions 51 to 1318 of SEQ ID NO:6,positions 51 to 1139 of SEQ ID NO:7, positions 51 to 1463 of SEQ ID NO:8,positions 41 to 2841 of SEQ ID NO:9, positions 46 to 2580 of SEQ ID NO:10,positions 51 to 1463 of SEQ ID NO:11, positions 21 to 2824 of SEQ ID NO:12, orpositions 21 to 2771 of SEQ ID NO:13.3. The reaction composition of claim 1 , wherein the sequence of (ii) comprises:positions 36 to 1115 of SEQ ID NO:4, positions 1715 to 2821 of SEQ ID NO:2,positions 1735 to 2834 of SEQ ID NO:3, positions 51 to 1167 of SEQ ID NO:5,positions 93 to 1178 of SEQ ID NO:6, positions 51 to 1130 of SEQ ID NO:7,positions 51 to 1158 of SEQ ID NO:8, positions 1735 to 2841 of SEQ ID NO:9,positions 1274 to 2413 of SEQ ID NO:10, positions 51 to 1158 of SEQ ID NO:11,positions 1715 to 2821 of SEQ ID NO:12, or positions 1665 to 2771 of SEQ ID NO:13.4. The ...

Manufacturing Process for Polysaccharide Beads

The invention discloses a method of manufacturing polysaccharide beads, comprising the steps of: i) providing a water phase comprising an aqueous solution of a polysaccharide; ii) providing an oil phase comprising at least one water-immiscible organic solvent and at least one oil-soluble emulsifier; iii) emulsifying the water phase in the oil phase to form a water-in-oil (w/o) emulsion; and iv) inducing solidification of the water phase in the w/o emulsion, wherein the organic solvent is an aliphatic or alicyclic ketone or ether. 1. A method of manufacturing polysaccharide beads , comprising the steps of:i) providing a water phase comprising an aqueous solution of a polysaccharide;ii) providing an oil phase comprising at least one water-immiscible organic solvent and at least one oil-soluble emulsifier;iii) emulsifying said water phase in said oil phase to form a water-in-oil (w/o) emulsion; andiv) inducing solidification of said water phase in said w/o emulsion,wherein said at least one organic solvent is an aliphatic or alicyclic ketone or ether.2. A method of manufacturing polysaccharide beads , comprising the steps of:i) providing a water phase comprising an aqueous solution of a polysaccharide;ii) providing an oil phase comprising at least one water-immiscible organic solvent and at least one oil-soluble emulsifier;iii) emulsifying said water phase in said oil phase to form a water-in-oil (w/o) emulsion; andiv) inducing solidification of said water phase in said w/o emulsion,{'sup': 1/2', '1/2', '1/2', '1/2', '1/2', '1/2, 'wherein said at least one organic solvent does not contain halogens and has Hansen solubility parameter values in the ranges of δD=15.0-18.5 MPa, δP=3.5-8.5 MPaand δH=4.0-5.5 MPa, or wherein said oil phase comprises a mixture of halogen-free water-immiscible organic solvents, said mixture having Hansen solubility parameter values in the ranges of δD=15.0-18.5 MPa, δP=3.5-8.5 MPaand δH=4.0-5.5 MPa.'}3. The method of wherein said at least one ...

ACID-DEGRADABLE AND BIOERODIBLE MODIFIED POLYHYDROXYLATED MATERIALS

Compositions and methods of making a modified polyhydroxylated polymer comprising a polyhydroxylated polymer having reversibly modified hydroxyl groups, whereby the hydroxyl groups are modified by an acid-catalyzed reaction between a polydroxylated polymer and a reagent such as acetals, aldehydes, vinyl ethers and ketones such that the modified polyhydroxylated polymers become insoluble in water but freely soluble in common organic solvents allowing for the facile preparation of acid-sensitive materials. Materials made from these polymers can be made to degrade in a pH-dependent manner. Both hydrophobic and hydrophilic cargoes were successfully loaded into particles made from the present polymers using single and double emulsion techniques, respectively. Due to its ease of preparation, processability, pH-sensitivity, and biocompatibility, of the present modified polyhydroxylated polymers should find use in numerous drug delivery applications. 1. An acid-degradable modified polyhydroxylated polymer comprising pendant hydroxyl groups , wherein at least 20% of the pendant hydroxyl groups are each directly linked to an acid degradable functional group , wherein the modified polyhydroxylated polymer is substantially insoluble in water.2. (canceled)3. (canceled)4. The acid-degradable modified polyhydroxylated polymer of claim 1 , wherein each functional group is selected from the group consisting of acetals claim 1 , aromatic acetals claim 1 , and ketals.5. (canceled)6. The acid-degradable modified polyhydroxylated polymer of claim 1 , wherein the polyhydroxylated polymer is selected from the group consisting of multiply-hydroxylated polymers claim 1 , polysaccharides claim 1 , carbohydrates claim 1 , polyols claim 1 , polyvinyl alcohol claim 1 , poly amino acids claim 1 , such as polyserine claim 1 , and other polymer such as 2-(hydroxyethyl)methacrylate.7. The acid-degradable modified polyhydroxylated polymer of claim 6 , wherein the polyhydroxylated polymer is a ...

SLOWLY DIGESTIBLE, SUSTAINED-TYPE ENERGY SUPPLYING AGENT

An object of the present invention is to provide a carbohydrate-derived energy supplying agent having slow digestibility and sustained digestibility functions. According to the present invention, there is provided a slowly digestible, sustained-type energy supplying agent comprising a saccharide composition which satisfies the following (A), (B), (C), and (D): (A) a percentage of α-1,6 bonds relative to all glycosidic bonds is 60% or more; (B) a content of saccharides having a degree of polymerization of 1 and 2 relative to all saccharides is 9 mass % or less; (C) a content of saccharides having a degree of polymerization within a range of 3 to 30 relative to all saccharides is 41 mass % or more; and (D) a content of saccharides having a degree of polymerization of 31 or more relative to all saccharides is 50 mass % or less. 19- (canceled)10. A saccharide composition which satisfies the following (A) , (B) , (C) , and (D):(A) a percentage of α-1,6 bonds relative to all glycosidic bonds being 60% or more;(B) a content of saccharides having a degree of polymerization of 1 and 2 relative to all saccharides being 9 mass % or less;(C) a content of saccharides having a degree of polymerization within a range of 3 to 30 relative to all saccharides being 41 mass % or more; and(D) a content of saccharides having a degree of polymerization of 31 or more relative to all saccharides being 50 mass % or less.11. The saccharide composition according to claim 10 , wherein the saccharide composition comprises 3 mass % or more of saccharides having a degree of polymerization within a range of 3 to 9 relative to all saccharides.12. The saccharide composition according to claim 10 , wherein the saccharide composition comprises 10 mass % or more of saccharides having a degree of polymerization within a range of 10 to 30 relative to all saccharides.13. The saccharide composition according to claim 10 , wherein claim 10 , in the above (A) claim 10 , (A-1) the percentage of α-1 claim 10 ,6 ...

CURABLE AQUEOUS COMPOSITIONS HAVING IMPROVED WET TENSILE STRENGTH AND USES THEREOF

According to the present invention, curable aqueous compositions provide excellent wet tensile strength and comprise (i) one or more polyacid, (ii) a mixture of two or more polyols including pentaerythritol, (iii) a carbohydrate, such as a starch, and (iv) from 0.5 to 12 wt. %, based on total solids, of one or more azetidinium group containing polyamidoamine resins. The compositions are useful in providing fibrous articles, such as heat resistant nonwovens. 1. A curable aqueous composition comprising (i) one or more polyacid comprising at least two carboxylic acid groups , or salts thereof; (ii) a mixture of two or more polyols including pentaerythritol and one or more additional polyol having at least two hydroxyl groups; (iii) from 0.5 to 12 wt. % , based on the total solids weight of the curable aqueous compositions , of one or more azetidinium group containing resins; and (iv) from 25 to 70 wt. % , based on the total solids weight of the curable aqueous compositions , of one or more carbohydrate , wherein the ratio of the number of equivalents of the carboxylic acid groups or salts thereof in the (i) one or more polyacid , to the total number of equivalents of the hydroxyl groups in the (ii) mixture of two or more polyols is from 1/0.01 to 1/10.2. The curable aqueous composition as claimed in claim 1 , wherein the composition further comprises (v) one or more phosphorous-containing accelerator.3. The curable aqueous composition as claimed in claim 1 , wherein the (i) one or more polyacids comprises a combination of at least one polymeric polyacid and an organic polybasic acid.4. The curable aqueous composition as claimed in claim 1 , wherein the (i) one or more polyacids is a polymeric polyacid chosen from polyacrylic acid (pAA) claim 1 , and pAA aqueous solution copolymers.5. The curable aqueous composition as claimed in claim 1 , comprising (iii) from 1 to 5 wt. % claim 1 , based on the total solids weight of the curable aqueous composition claim 1 , of one or ...

Washing and cleaning multi-layer films, method for the production and use thereof

Described herein is a washing- and cleaning-active multilayer film including at least one layer including a polymer composition obtainable by free-radical polymerization of a monomer composition including at least one α,β-ethylenically unsaturated carboxylic acid or a salt or an anhydride thereof, where the free-radical polymerization is effected in the presence of at least one polyether component. Also described herein is a process for producing the multilayer film, methods of using the multilayer film and a sheath or coating for a washing or cleaning composition portion including the multilayer film.

MEDIA AND METHODS FOR EXPANSION OF PLURIPOTENT STEM CELLS

The present disclosure provides methods and reagents for culturing pluripotent stem cells. The method comprises a first step of culturing in a medium comprising inhibitors of GSK-3β, JNK, p38, PKC and Erk1/2, followed by a second step of culturing in a medium comprising inhibitors of GSK-3β, JNK, p38 and PKC, and not comprising an inhibitor of Erk1/2. The medium of the second step may also further comprise dextran sulfate. The pluripotent stem cells produced using the methods and reagents provided may also be differentiated into a cell type of interest. The methods and reagents provided in this disclosure offer robust and scalable technologies for manufacturing the quantities of cells anticipated to be required for widespread patient access. 1. A method for culturing a population of pluripotent stem cells , the method comprising:culturing in a first medium comprising one or more inhibitors of GSK-3β, one or more inhibitors of JNK, one or more inhibitors of p38, one or more inhibitors of PKC and one or more inhibitors of Erk1/2; andculturing in a second medium comprising one or more inhibitors of GSK-3β, one or more inhibitors of JNK, one or more inhibitors of p38 and one or more inhibitors of PKC, and not comprising an inhibitor of Erk1/2.2. The method of claim 1 , wherein the first and second media further comprise one or more of fibroblast growth factor 2; transforming growth factor-β1; a STAT3 activator; insulin; ascorbic acid; albumin; N2 supplement; non-essential amino acids; glutamine; and serum replacement.3. The method of claim 1 , wherein the pluripotent stem cells cultured in the second medium are cultured as aggregates.4. The method of claim 1 , wherein the second medium further comprises a polysulfated compound5. The method of claim 1 , wherein the growth rate of the pluripotent stem cells cultured in the first medium and the second medium is increased compared to pluripotent stem cells not cultured in the first medium and the second medium.6. A method ...

BIO-BASED BINDERS FOR INSULATION AND NON-WOVEN MATS

An aqueous binder composition is provided that includes a carbohydrate and a crosslinking agent. In exemplary embodiments, the carbohydrate-based binder composition may also include a catalyst, a coupling agent, a process aid, a crosslinking density enhancer, an extender, a moisture resistant agent, a dedusting oil, a colorant, a corrosion inhibitor, a surfactant, a pH adjuster, and combinations thereof. The carbohydrate may be natural in origin and derived from renewable resources. Additionally, the carbohydrate polymer may have a dextrose equivalent (DE) number from 2 to 20. In at least one exemplary embodiment, the carbohydrate is a water-soluble polysaccharide such as dextrin or maltodextrin and the crosslinking agent is citric acid. Advantageously, the carbohydrates have a low viscosity and cure at moderate temperatures. The environmentally friendly, formaldehyde-free binder may be used in the formation of insulation materials and non-woven chopped strand mats. A method of making fibrous insulation products is also provided. 1. An aqueous binder composition for use in the formation of fiberglass insulation and non-woven mats , the binder composition comprising:maltodextrin having a dextrose equivalent number from 2 to 14; andat least one crosslinking agent selected from polycarboxylic acids, salts of polycarboxylic acid, anhydrides, monomeric and polymeric polycarboxylic acid with anhydride, citric acid, salts of citric acid, adipic acid, salts of adipic acid, polyacrylic acid, salts of polyacrylic acid, polyacrylic acid based resins, and combinations thereof.2. The binder composition of claim 1 , wherein the at least one crosslinking agent is selected from citric acid claim 1 , salts of citric acid claim 1 , polyacrylic acid claim 1 , salts of polyacrylic acid claim 1 , and combinations thereof.3. The binder composition of claim 1 , wherein the at least one crosslinking agent has a molecular weight of from 90 g/mol to 10 claim 1 ,000 g/mol.4. The binder ...

POLYPEPTIDE HAVING THE ABILITY TO FORM CONNECTIONS OF GLUCOSYL UNITS IN ALPHA-1,3 ON AN ACCEPTOR

Polypeptides having the ability to specifically form connections of glucosyl units in alpha 1,3 on an acceptor having at least one hydroxyl moiety are presented. The polypeptides include i) the pattern I of sequence SEQ ID NO: 1, ii) the pattern II of sequence SEQ ID NO: 2, iii) the pattern III of sequence SEQ ID NO: 3, and iv) the pattern IV of sequence SEQ ID NO: 4, or derivates from one or several of said patterns, wherein the polypeptide furthermore has an aspartic residue (D) at position 5 of the pattern II (SEQ ID NO: 2), a glutamic acid residue (E) at position 6 of the pattern III (SEQ ID NO: 3) an an aspartic acid residue (D) at position 6 of the pattern IV (SEQ ID NO: 4). Methods for producing acceptors connected to glucosyl units in alpha 1,3 using the polypeptides are also provided. 1. A recombinant polypeptide comprising an amino acid sequence that is at least 99 percent identical to SEQ ID NO: 12 , and wherein said polypeptide maintains an aspartic acid residue (D) at position 5 of the pattern II (SEQ ID NO: 2) , a glutamic acid residue (E) at position 6 of the pattern III (SEQ ID NO: 3) , and an aspartic acid residue (D) at position 6 of the pattern IV (SEQ ID NO: 4).2. An expression vector comprising a nucleic acid encoding the recombinant polypeptide of .3. A host cell comprising the vector of .4. A composition comprising the recombinant polypeptide of .5. A composition comprising the expression vector of .6. A composition comprising the host cell of .7. A method of producing a recombinant polypeptide from a cell claim 3 , said method comprising culturing the host cell of so that the polynucleotide encoding the recombinant polypeptide is expressed and the recombinant polypeptide is secreted.8. A method for producing acceptors connected to glucosyl units in alpha 1 claim 3 ,3 comprising a rate of connections of such glucosyl units in alpha 1 claim 3 ,3 between 1 and 50% claim 3 , said method comprising the steps of:(i) mixing in a reaction medium:an ...

A SOLID COMPOSITION COMPRISING A POLYSACCHARIDE AND A HYDROPHOBIC COMPOUND, THE PROCESS AND USE THEREOF

The present invention provides a solid composition comprising a polysaccharide and a hydrophobic compound having a melting point of between 30° C. and 90° C. The solid composition may further comprise a quaternary ammonium compound, wherein the weight ratio of the polysaccharide and the hydrophobic compound is between 1:50 and 50:1. Preferably, the solid composition is substantially free or completely free of water. The solid composition shows excellent stability at a temperature up to 45° C. The present invention also provides a process for preparing the solid composition and a liquid composition comprising said solid composition, and a method for conditioning a fabric by using said solid composition or said liquid composition as well. 119-. (canceled)20. A solid composition comprising a polysaccharide and a hydrophobic compound having a melting point of between 30° C. and 90° C.21. The solid composition according to claim 20 , wherein the hydrophobic compound is an ester of fatty acid.22. The solid composition according to claim 20 , wherein the polysaccharide is a cationic polysaccharide claim 20 , a nonionic polysaccharide claim 20 , or a mixture thereof.23. The solid composition according to claim 20 , wherein the polysaccharide is a cationic guar claim 20 , a nonionic guar claim 20 , or a mixture thereof.24. The solid composition according to claim 20 , wherein the solid composition further comprises a quaternary ammonium compound claim 20 , and the weight ratio of the polysaccharide and the hydrophobic compound is between 1:50 and 50:1.25. The solid composition according to claim 24 , wherein the weight ratio of the polysaccharide and the hydrophobic compound is between 1:30 and 30:1.26. The solid composition according to claim 24 , wherein the weight ratio of the polysaccharide and the hydrophobic compound is between 1:10 and 10:1.27. The solid composition according to claim 24 , wherein the quaternary ammonium compound has the general formula (I):{'br': ...

ELECTROSPUN DEXTRAN FIBERS AND DEVICES FORMED THEREFROM

The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen. 1. A hemostatic product comprising:a hemostatic agent;a sucrose coating applied to the hemostatic agent; anda dextran support to which the sucrose coated hemostatic agent is applied to form the hemostatic product.2. The hemostatic product of claim 1 , wherein the sucrose coated hemostatic agent is in a particulate form.3. The hemostatic product of claim 1 , and further comprising mixing the sucrose coated hemostatic agent with a bulking agent before the sucrose coated hemostatic agent is applied to the dextran support.4. The hemostatic product of claim 1 , wherein the hemostatic agent comprises at least one of thrombin and fibrinogen.5. The hemostatic product of claim 4 , wherein the thrombin is in the hemostatic product at a concentration of between about 100 units and about 10 claim 4 ,000 units and wherein the fibrinogen is in the hemostatic product at a concentration of between about 1 grams and about 3 grams.6. The hemostatic product of claim 1 , wherein the dextran support comprises electrospun dextran fibers.7. The hemostatic product of claim 1 , wherein the hemostatic product further comprises a support material to which the dextran support is applied and wherein the support material comprises at least one of gauze claim 1 , compressed electrospun dextran claim 1 , polyglycolytic acid polymers claim 1 , polylactic acid polymers claim 1 , caprolactone polymers and charged nylon.8. A method of inducing hemostasis in a wound claim ...

METHODS AND COMPOSITIONS FOR MAINTAINING THE CONFORMATION AND STRUCTURAL INTEGRITY OF BIOMOLECULES

A composition includes a target pharmaceutical or biological agent, a solution containing the target pharmaceutical or biological agent, and substrate that is soluble in the solution. The substrate is capable of being solidified via a solidification process and the solidification process causes the substrate to become physically or chemically cross-linked, vitrified, or crystallized. As a result of the solidification process, particles are formed. The target pharmaceutical or biological agent within the solution retains proper conformation to ultimately produce a desired effect. 1. A method of forming particles that preserves biological activity of a pharmaceutical or biological agent when exposed to an organic solvent , the method comprising: a pharmaceutical or a biological agent; and', 'a substrate that is soluble in the solution, comprising one or more chemical species;, 'preparing a solution comprisingforming particles from the solution, wherein the forming comprises a process of at least one of physical or chemical cross-linking, vitrification, or crystallization of the substrate, or combinations thereof, and wherein the pharmaceutical or biological agent is entrapped by the formed particles; andwherein the biological activity of the pharmaceutical or biological agent is preserved following exposure of the particles to the organic solvent.2. The method according to claim 1 , further comprising:selecting the organic solvent; andmixing or suspending the particles in the organic solvent.3. The method according to claim 1 , wherein one or more of a surfactant claim 1 , a stabilizer claim 1 , or an emulsifier are incorporated into the substrate prior to claim 1 , during claim 1 , or after particle formation.4. The method according to claim 1 , wherein the particles are obtained by a process comprising:forming an emulsion of an aqueous phase dispersed in an organic phase, wherein the substrate and the pharmaceutical or biological agent comprise the dispersed aqueous ...

ENZYMATICALLY POLYMERIZED GELLING DEXTRANS

Compositions are disclosed herein comprising dextran that comprises (i) 87-93 wt % glucose linked at positions 1 and 6; (ii) 0.1-1.2 wt % glucose linked at positions 1 and 3; (iii) 0.1-0.7 wt % glucose linked at positions 1 and 4; (iv) 7.7-8.6 wt % glucose linked at positions 1, 3 and 6; and (v) about 0.4-1.7 wt % glucose linked at (a) positions 1, 2 and 6, or (b) positions 1, 4 and 6. Aqueous forms of this composition have enhanced viscosity profiles. Further disclosed are methods of using compositions comprising dextran, such as increasing the viscosity of an aqueous composition. Enzymatic reactions for producing dextran are also disclosed. 1. A composition comprising dextran , wherein said dextran comprises:(i) about 87-93 wt % glucose linked at positions 1 and 6;(ii) about 0.1-1.2 wt % glucose linked at positions 1 and 3;(iii) about 0.1-0.7 wt % glucose linked at positions 1 and 4;(iv) about 7.7-8.6 wt % glucose linked at positions 1, 3 and 6; and (a) positions 1, 2 and 6, or', '(b) positions 1, 4 and 6;, '(v) about 0.4-1.7 wt % glucose linked at{'i': 'Leuconostoc mesenteroides', 'wherein the weight-average molecular weight (Mw) of said dextran is about 50-200 million Daltons, the z-average radius of gyration of said dextran is about 200-280 nm, and the dextran optionally is not a product of a glucosyltransferase enzyme.'}2. The composition of claim 1 , wherein the dextran comprises:(i) about 89.5-90.5 wt % glucose linked at positions 1 and 6;(ii) about 0.4-0.9 wt % glucose linked at positions 1 and 3;(iii) about 0.3-0.5 wt % glucose linked at positions 1 and 4;(iv) about 8.0-8.3 wt % glucose linked at positions 1, 3 and 6; and (a) positions 1, 2 and 6, or', '(b) positions 1, 4 and 6., '(v) about 0.7-1.4 wt % glucose linked at3. The composition of claim 1 , wherein the dextran comprises chains linked together within a branching structure claim 1 , wherein said chains are similar in length and comprise substantially alpha-1 claim 1 ,6-glucosidic linkages.4. The ...

Compositions and Methods for Reducing Oxidative Damage

Polymeric compositions are provided that include a poly(ethylene glycol), a viscoelastic polymer, and an antioxidant, where, in polymerized form, the compositions have a refractive index of about 1.30 to about 1.40. Methods of synthesizing the compositions are also provided and include the steps of heating an amount of water; adding a buffering agent to the water to form a buffer solution; mixing a poly(ethylene glycol) and a viscoelastic polymer into the buffer solution to form a reactive mixture; adding a plurality of antioxidant particles to the reactive mixture; and removing suspended gas bubbles from the reactive mixture. Methods of preventing oxidative damage to an eye lens of a subject are further provided and include administering the foregoing polymeric compositions to the eye lens of the subject. 120-. (canceled)21. A method of reducing or preventing oxidative damage to an eye lens of a subject , the method comprising contacting an eye lens of a subject with a composition comprising a polysaccharide antioxidant , wherein the composition has a refractive index of about 1.3 to about 1.4.22. The method according to claim 21 , wherein contacting the eye lens of the subject comprises coating the eye lens with the composition.23. The method according to claim 21 , wherein the composition is contacted with the eye lens during vitrectomy.24. The method according to claim 21 , wherein the composition is contacted with the eye lens in an amount sufficient to prevent post-vitrectomy cataract formation.25. The method according to claim 21 , wherein the polysaccharide antioxidant is trehalose.26. The method according to claim 25 , wherein the refractive index of the composition is from about 1.33 to about 1.36.27. The method according to claim 26 , wherein the composition has a surface energy of less than about 4 dyne/cm or greater than about 40 dyne/cm.28. The method according to claim 27 , wherein the composition has an elasticity of about 50 N/m to about 1000 N/m.29 ...

Crosslinked dextran and crosslinked dextran-poly alpha-1,3-glucan graft copolymers

Compositions are disclosed herein comprising one or more crosslinked dextrans or crosslinked dextran-poly alpha-1,3-glucan graft copolymers. Further disclosed are processes for preparing such crosslinked materials, as well as their use in absorption applications.

NONWOVEN WEBS COMPRISING POLYSACCHARIDES

Disclosed herein are nonwoven webs comprising a nonwoven substrate and a binder comprising a polysaccharide. In one embodiment, the polysaccharide can comprise poly alpha-1,3-glucan, a poly alpha-1,3-glucan ether compound as disclosed herein, a poly alpha-1,3-glucan ester compound as disclosed herein, a graft copolymer comprising a backbone comprising dextran and poly alpha-1,3-glucan side chains, a crosslinked graft copolymer comprising a backbone comprising dextran and poly alpha-1,3-glucan chains, or a mixture thereof. Also disclosed are articles comprising the nonwoven webs, and methods of making the nonwoven webs. 2. The nonwoven web of claim 1 , wherein the nonwoven substrate is an airlaid nonwoven substrate claim 1 , a multi-bonded airlaid nonwoven substrate claim 1 , a carded nonwoven substrate claim 1 , a wet laid nonwoven substrate claim 1 , a spun lace nonwoven substrate claim 1 , a meltblown nonwoven substrate claim 1 , or a spun bond nonwoven substrate.3. The nonwoven web of claim 1 , wherein the nonwoven substrate comprises natural fibers; synthetic fibers comprising rayon claim 1 , polyester claim 1 , polyamide claim 1 , polyolefin claim 1 , or combinations thereof; bicomponent fibers; or combinations thereof.4. The nonwoven web of claim 1 , wherein the binder further comprises a polymeric component comprising a polymer polymerized from one or more of acrylic monomers claim 1 , vinyl monomers claim 1 , styrene monomers claim 1 , or a combination thereof.5. The nonwoven web of claim 1 , wherein the web comprises the binder in an amount from about 0.5 weight percent to about 50 weight percent claim 1 , based on the total weight of the nonwoven substrate and the binder.6. The nonwoven web of claim 1 , wherein the polysaccharide is in the form of fibrids.7. The nonwoven web of claim 1 , wherein the nonwoven substrate comprises cellulosic fibers claim 1 , the polysaccharide comprises poly alpha-1 claim 1 ,3-glucan claim 1 , and the binder further comprises ...

TEMPLATED ASSEMBLY OF COLLAGEN FIBERS AND USES THEREOF

The present invention relates to a biomaterial fabrication process for the manufacture of a collagen based fabric for an aligned collagen fiber network. 1. A biomaterial fabrication process for the manufacture of a collagen based fabric for an aligned collagen fiber network , the process comprising:a. providing a collagen-dextran polymer (CDP) composition comprising dextran and collagen;b. applying the CDP composition to a first surface of a first substrate;c. contacting the CDP composition with a first surface of a second substrate, thereby interposing the CDP composition between the first substrate and the second substrate;d. forming a plurality of elongated CDP fibers by pressing and separating the first and second substrates along a horizontal axis thereby elongating the CDP composition and forming the plurality of elongated CDP fibers;e. placing the elongated CDP fibers onto a positionable stage thereby forming a CDP fiber layer or CDP fabric of collected CDP fibers; andf. contacting the CDP fiber layer or CDP fabric with a solvent to dissolve the dextran in the CDP fiber layer or CDP fabric thereby forming the collagen based fabric.2. The biomaterial fabrication process according to claim 1 , wherein the ratio of collagen to dextran in the CDP composition can range from about 0.1% to about 1.57% collagen to about 99.9% to about 98.43% dextran.3. The biomaterial fabrication process according to claim 2 , wherein the ratio of collagen to dextran in the CDP composition can range from about 0.2% to about 0.79% collagen to about 99.8% to about 99.21% dextran.4. The biomaterial fabrication process according to claim 1 , wherein the collagen is Type I collagen.5. The biomaterial fabrication process according to claim 1 , wherein the CDP composition has a collagen:dextran mass fraction ranging from 0.004 to 0.008.6. The biomaterial fabrication process according to claim 1 , wherein the CDP composition at 22° C. has a viscosity ranging from about 15 claim 1 ,000 ...

PROTEINS HAVING WOUND HEALING EFFICACY AND METHOD FOR ISOLATION FROM HUMAN HAIR

The invention is a non-hydrated, keratin wound dressing film comprising a fraction of keratins isolated from a solution of extracted keratins. Said fraction enables the formation of film with greater flexibility that can be achieved in film made from the unfractionated keratin extract. Also disclosed is a process of forming wound dressings and a method of obtaining said keratin fraction from an extract of human hair or other keratin raw materials. 1. A film comprising a fraction of keratin proteins separated from an original extracted keratin protein mixture , wherein said film comprises consolidated particles of said fraction; wherein said film possesses a greater flex-fatigue life or exhibits a greater drape angle than a comparable film comprising consolidated particles of the original extracted keratin protein mixture from which it was fractionally separated.2. The film of in which said original extracted keratin protein mixture is obtained from human hair.3. The film of in which said extracted keratin proteins are obtained from feathers.4. A process of obtaining a fraction of keratin proteins claim 1 , the process comprising:a. Providing a solution of keratin proteins by extracting a keratin raw material in an alkaline aqueous solution comprised of a reducing agent, a denaturing agent, and buffer salts;b. Fractionally precipitating keratins from the solution of keratin proteins of step a. by addition of a first water-miscible organic solvent and collecting a solution of the remaining non-precipitated keratins by filtration;c. Further fractionally precipitating keratins from the solution of step b. by addition of a second water-miscible organic solvent and collecting the precipitated fraction of keratin solids on a filter; thereby obtaining said fraction of keratin proteins.5. The process of claim 4 , wherein said first water-miscible organic solvent is ethanol and said second water-miscible organic solvent is acetone.6. A process of obtaining a fraction of ...

Biochips with surfaces coated with polysaccharide-based hydrogels

The present invention provides a substrate having a polymerized, polysaccharide-based hydrogel attached to the surface. The hydrogel can be derivatized with binding functionalities that bind analytes from a sample. The invention further provides methods of using the device and gels that are capable of selectively binding one or more analytes from a sample.

Polymeric Carriers and Methods

Provided are methods of controlling disassociation of cells from a carrier, compositions, and methods of collecting cells. The methods of controlling disassociation of cells from a carrier may include contacting a polymeric carrier with one or more digesting agents to disassociate at least a portion of a plurality of cells from the polymeric carrier. The polymeric carrier may be crosslinked with a crosslinker including at least one of a redox sensitive moiety, a UV light sensitive moiety, a pH sensitive moiety, and a temperature sensitive moiety. 8. The method of claim 1 , wherein the plurality of cells comprises human Mesenchymal stem cells (hMSCs) claim 1 , endothelial cells claim 1 , or a combination thereof.9. The method of claim 1 , wherein the polymeric carrier further comprises dextran claim 1 , hyaluronic acid claim 1 , agarose claim 1 , chitosan claim 1 , alginate claim 1 , polyvinyl alcohol claim 1 , polyamino acid claim 1 , calcium alginate claim 1 , polyacrylate claim 1 , polyethylene glycol claim 1 , polyethylene imine claim 1 , polyanhydride claim 1 , or a combination thereof.10. The method of claim 1 , wherein the polymeric carrier further comprises dextran claim 1 , hyaluronic acid claim 1 , agarose claim 1 , chitosan claim 1 , alginate claim 1 , polyvinyl alcohol claim 1 , polyamino acid claim 1 , or a combination thereof.11. The method of claim 1 , wherein the polymeric carrier is a polymeric carrier bead.12. The method of claim 1 , wherein the one or more digesting agents comprises a reducing agent.13. The method of claim 12 , wherein the reducing agent comprises dithiothreitol (DTT) claim 12 , cysteine claim 12 , glutathione claim 12 , or a combination thereof.14. The method of claim 12 , wherein the reducing agent comprises a solution of dithiothreitol (DTT) having a concentration of about 5 mM to about 25 mM.15. The method of claim 14 , wherein the solution of dithiothreitol further comprises sodium citrate claim 14 , trypsin claim 14 , or a ...

一种具有防水透气性能的包装膜材料及其制备方法

本发明公开了具有防水透气性能的包装膜材料及其制备方法，其以酚醛树脂、水溶性葡聚糖、聚乙烯醇、柠檬酸三丁酯为主要成分，通过加入己二酸丙二醇聚酯、凡士林、薏仁油、沸石粉、四硼酸钾、脱氢乙酸、氧化镧、聚乙烯蜡粉、甲基乙基酮肟、增塑剂、偶联剂，辅以恒温水浴、离心分离、真空干燥、研磨细化、微波处理、混炼、塑化、熔融挤出、热压成型等工艺，使得制备而成的具有防水透气性能的包装膜材料，其具有优异的防水透气性，且物理强度高，能够满足行业的要求，具有较好的应用前景。

Hydrogel with controllable biodegradation behavior and the manufacturing method thereof

PURPOSE: A hydrogel is provided to be used for an operation regardless of the formed shape of a bone, to control a body decomposition rate, and to be degradable after osteogenesis. CONSTITUTION: A hydrogel comprises PEG(polyethylene glycol) which has a polymerization group; an IPN(interpentetrating polymer network) which is capable of being penetrated and comprising photopolymerized PEG; natural polymer additives which have a higher viscosity level and a body decomposition rate which can increase a body decomposition rate; and photopolymerization initiator which has radicals for initiating the PEG. The natural polymer additives comprise at least one selected from carboxy methyl cellulose, heparin sulfate, hyaluronic acid, collage, chitosan, dextran, and alginate.

可再水化的硫醇化多糖颗粒和海绵状物

组织和其他身体结构可以使用由自由流动的可再水化颗粒或可再水化海绵状物制成的水化组合物进行保护，所述组合物包含基本上不含胶原的脱水热交联硫醇化多糖。交联或未交联的多糖颗粒的再水化可以通过将颗粒分散在生物相容的水易混合的极性分散剂诸如乙醇中并且将分散体与充足的所述颗粒的水性溶剂合并从而将它们转变为粘性水凝胶来进行而不会结块。水化颗粒或海绵状物可以有助于将受损的、发炎的或手术修复的表面恢复成正常状态，例如，通过一种或多种愈合机制诸如炎性应答的调节、吞噬作用、粘膜重塑、纤毛再生或其他正常功能的完全或部分恢复。

氧化的右旋糖酐

本文中披露了包含氧化的右旋糖酐化合物的组合物。氧化的右旋糖酐化合物是通过在水性条件下使右旋糖酐与至少一种N‑氧代铵盐、至少一种高碘酸盐化合物和/或至少一种过氧化物化合物接触来产生的。

Resin composition, molding thereof and process for producing the resin composition

Highly insulative cementitious matrices and methods for their manufacture

Insulation barriers incorporating a cementitious structural matrix formed from a cementitious mixture including a hydraulic cement and water. The insulation barriers are manufactured from cementitious materials in order to be lightweight, insulative, less expensive, and more environmentally compatible than those currently used; they may augment, and even take the place of, traditional insulation materials including insulations made of glass fibers, polyurethane foam, urea-formaldehyde foam, polystyrene, wood fiber, cellulose fiber, rock-wool, etc. The cementitious structural matrix of the insulation barriers usually includes a hydraulic cement paste (formed from the reaction of water with, e.g., a portland-type cement) in combination with a rheology-modifying agent, such as methylhydroxyethylcellulose, and a lightweight aggregate material, which lowers the density of the insulation barrier and increases its insulation ability. Fibrous materials may be incorporated into the cementitious mixture to increase the strength of the final product, while a discontinuous phase of nonagglomerated voids may be incorporated into the cementitious structural matrix to decrease the density and increase the insulation ability of the final product.

Method for producing nanoparticles of polysaccharides

FIELD: chemistry. SUBSTANCE: method for producing nanoparticles of polysaccharides and their derivatives, partial oxidation thereof for the production of aldehyde groups and attachment of compounds with an amino group or another group with R-NH 2 , which react with an aldehyde group, in which a polysaccharide with a molecular weight of up to 1000 kD or its derivative is oxidized to produce aldehyde groups until an oxidation ratio of 5% to 55% of the sugar chains is produced, and then, at least, one nanomaterial that after attaching the aldehyde group, exhibits hydrophobic properties, is selected from the group consisting of: aliphatic or aromatic organic amines containing of 4 to 20 carbon atoms, amides and hydrazides of aliphatic and aromatic organic acids having from 4 to 20 carbon atoms, the hydrophobic amino acids, phosphatidylethanolamine, and, at least, one active substance containing, at least, one amino-, amido- or hydrazide group is added to a solution of the oxidized polysaccharide in water or in a mixture of water and organic solvent, the reaction is conducted at pH of 1 to 9, at a temperature of 10 to 100°C, and the total molar ratio of amino groups to aldehyde groups is of 20 to 0.5. A nanoparticle is also described. EFFECT: method for producing polysaccharide nanoparticles under mild conditions has been developed to provide covalent bonds of therapeutic compounds that are sensitive to an aggressive environment. 20 cl, 2 dwg, 8 ex РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 632 019 C2 (51) МПК C08B 1/12 (2006.01) B82B 1/00 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (21)(22) Заявка: 2014133962, 12.03.2013 (24) Дата начала отсчета срока действия патента: 12.03.2013 (72) Автор(ы): СИАЧ Томаш (PL), ВАСИАК Ига (PL) (73) Патентообладатель(и): НАНОВЭЛЁС СП. З О.О. (PL) Дата регистрации: (56) Список документов, цитированных в отчете о поиске: US 2006/013885 A1, 19.01.2006. WO Приоритет(ы): (30) Конвенционный ...

Hydraulically settable containers and other articles for storing, dispensing, and packaging food or beverages

Containers incorporating a hydraulically settable structural matrix including a hydraulically settable binder such as cement for use in the storing, dispensing, and/or packaging of food and beverage products are disclosed. The disposable and nondisposable food and beverage articles of manufacture have high tensile, compressive, and flexural strengths, and are lightweight, insulative (if desired), inexpensive, and more environmentally compatible than those currently used. These disposable containers and cups are particularly useful for dispensing hot and cold food and beverages in the fast food restaurant environment. The structural matrix of the food and beverage containers includes a hydraulic cement paste (formed from the reaction of water with, e.g., a portland-type cement) preferably in combination with a rheology-modifying plasticizer, such as methylhydroxyethylcellulose, various aggregate materials, and fibrous materials, which provide desired properties at a cost which is economical.

Methods for the extrusion of novel, highly plastic and moldable hydraulically settable compositions

Hydraulically settable mixtures and methods for extruding such mixtures into a variety of objects which are form-stable in the green state. High green strength is achieved by increasing the yield stress of the mixture while maintaining adequate extrudability. Optimizing the particle packing density while including a deficiency of water yields a hydraulically settable mixture which will flow under pressures typically associated with the extrusion of clay or plastic. In addition, a rheology-modifying agent can be added to increase the yield stress of the mixture while not significantly increasing the viscosity. The desired strength properties and other performance criteria of the final hardened extruded product are controlled by adding aggregates, fibers, a hydraulically settable binder, water, and other admixtures.

Methods for manufacturing articles of manufacture from hydraulically settable sheets

Compositions and methods for manufacturing containers from sheets having a hydraulically settable matrix. Suitable compositions are prepared by mixing together a hydraulic binder, water, and appropriate additives (such as aggregates, fibers, and rheology-modifying agents) which impart predetermined properties so that a sheet formed therefrom has the desired performance criteria. Hydraulically settable sheets are formed from the mixture by extrusion, then calendering the sheets using a set of rollers and then drying the sheets in an accelerated manner to substantially harden the sheets. The resulting hydraulically settable sheets may have properties substantially similar to sheets made from presently used materials like paper, cardboard, polystyrene, or plastic. The sheets can be laminated, corrugated, coated, printed on, scored, perforated, cut, folded, rolled, spiral wound, molded, assembled and seamed to mass produce articles of manufacture from the sheets such as food and beverage containers.

Laminated articles of manufacture fashioned from sheets having a highly inorganically filled organic polymer matrix

Compositions, methods, and apparatus for manufacturing sheets having a highly inorganically filled matrix. Suitable inorganically filled mixtures are prepared by mixing together an organic polymer binder, water, one or more aggregate materials, fibers, and optional admixtures in the correct proportions in order to form a sheet which has the desired performance criteria. The inorganically filled mixtures are formed into sheets by first extruding the mixtures and the passing the extruded materials between a set of rollers. The rolled sheets are dried in an accelerated manner to form a substantially hardened sheet, such as by heated rollers and/or a drying chamber. The inorganically filled sheets may have properties substantially similar to sheets presently made from traditional materials like paper, paperboard, polystyrene, plastic, or metal. Such sheets can be rolled, pressed, scored, perforated, folded, and glued. They have especial utility in the mass production of containers, particularly food and beverage containers.

Resin composition, molded product from resin composition and method for preparing resin composition

Disclosed is a biodegradable resin composition containing at least one biodegradable organic high molecular compound, a flame retardant additive containing a phosphorus-containing compound, and a hydrolysis suppressing agent suppressing the hydrolysis of the at least one biodegradable organic high molecular compound. An aliphatic polyester resin is polylactic acid, polycaprolactone, polyhydroxy lactic acid, polyhydroxy valeric acid, polyethylene succinate, polybutylene succinate, polybutylene adipate, polymalic acid, polyesters synthesized by fermentation, or a copolymer containing at least one of them. A polysaccharide is cellulose, starch, chitin, chitosan, dextrane, a derivative of at least one of them, or a copolymer containing at least one of them.

Highly inorganically filled compositions

Compositions, methods, and apparatus for manufacturing sheets having a highly inorganically filled matrix prepared by mixing together an organic polymer binder, water, one or more inorganic aggregate materials, fibers, and optional admixtures in the correct proportions in order to form a sheet which has the desired performance criteria. The inorganically filled mixtures are formed into sheets by first extruding the mixtures and then passing the extruded materials between a set of rollers. The rolled sheets are dried in an accelerated manner to form a substantially hardened sheet, such as by heated rollers and/or a drying chamber. The inorganically filled sheets may have properties substantially similar to sheets presently made from traditional materials like paper, paperboard, polystyrene, plastic, or metal. Such sheets can be rolled, pressed, scored, perforated, folded, and glued. They have particular utility in the mass production of articles, such as food and beverage containers, and packaging materials.

Articles of manufacture fashioned from sheets having a highly inorganically filled organic polymer matrix

Compositions, methods, and apparatus for manufacturing sheets having a highly inorganically filled matrix. Suitable inorganically filled mixtures are prepared by mixing together an organic polymer binder, water, one or more aggregate materials, fibers, and optional admixtures in the correct proportions in order to form a sheet which has the desired performance criteria. The inorganically filled mixtures are formed into sheets by first extruding the mixtures and then passing the extruded materials between a set of rollers. The rolled sheets are dried in an accelerated manner to form a substantially hardened sheet, such as by heated rollers and/or a drying chamber. The inorganically filled sheets may have properties substantially similar to sheets presently made from traditional materials like paper, paperboard, polystyrene, plastic, or metal. Such sheets can be cut, rolled, pressed, scored, perforated, folded, and glued to fashion articles from the sheets. They have especial utility in the mass production of containers, particularly food and beverage containers.

Sheets having a highly inorganically filled organic polymer matrix

Compositions and methods for manufacturing sheets having a highly inorganically filled matrix. Suitable inorganically filled mixtures are prepared by mixing together an organic polymer binder, water, one or more inorganic aggregate materials, fibers, and optional admixtures in the correct proportions in order to form a sheet which has the desired performance criteria. The inorganically filled mixtures are formed into sheets by first extruding the mixtures and the passing the extruded materials between a set of rollers. The rolled sheets are dried in an accelerated manner to form a substantially hardened sheet, such as by heated rollers and/or a drying chamber. The inorganically filled sheets may have properties substantially similar to sheets presently made from traditional materials like paper, paperboard, polystyrene, plastic, or metal. Such sheets can be rolled, pressed, scored, perforated, folded, and glued. They have especial utility in the mass production of containers, particularly food and beverage containers.

Adhesive composition for lithium secondary battery and the lithium secondary battery including it

本发明公开了用于锂二次电池的粘合剂组合物以及包括其的锂二次电池，该粘合剂组合物包括共聚物，该共聚物包括：基于(甲基)丙烯酰胺的第一结构单元，包含羧酸或其盐的第二结构单元，和包含吗啉环或硫代吗啉环的第三结构单元。

Sustained release preparations composed of biocompatible complex microparticles

A particle includes a complex between a bioactive agent and a complexing agent, provided that the bioactive agent is other than a polynucleotide and an oligonucleotide, and wherein the particle has a bioactive function. The particle has a diameter from about 5 nm to about 100 microns. In certain embodiments, the bioactive agent is a member selected from the group consisting of a growth factor, a hormone, a peptide, a protein, and polysaccharide. In certain embodiments, the complexing agent is a member selected from the group consisting of polysaccharides, glycosaminoglycans, complex carbohydrates, polyacids, modifications and derivatives thereof. Also provided is a method of making the particle. Further provided is a method of administering the particle, including providing the particle, which is adapted to gradually release the bioactive agent; and thereby administering the particle.

Poly-alpha-1,3-1,6-glucans for viscosity modification

本文公开了一种组合物，所述组合物包含重均聚合度(DP w )为至少1000的聚α‑1，3‑1，6‑葡聚糖。该葡聚糖聚合物包含至少30％的α‑1，3键和至少30％的α‑1，6键。本发明还公开了合成聚α‑1，3‑1，6‑葡聚糖的葡糖基转移酶。本发明还公开了聚α‑1，3‑1，6‑葡聚糖的醚衍生物和使用这类衍生物作为粘度调节剂的方法。

Gelling dextran ethers

Polypeptides capable of producing glucans having alpha-1,2 branches and use of the same

Disclosed herein are proteins capable of forming glucans having alpha-1,2 linkages/branches, reactions and methods for producing such glucan, compositions comprising such glucan, and various applications thereof.

Alpha-1, 3-glucan graft copolymers

本文公开了包含接枝共聚物的组合物，所述接枝共聚物包含：(i)含有已经约1％‑25％α‑1，2分支修饰的右旋糖酐的骨架，和(ii)含有至少约50％α‑1，3糖苷键的一个或多个α‑1，3‑葡聚糖侧链。还公开了用于生产此类接枝共聚物的反应，以及其在衍生物、膜和各种其他应用中的用途。

Dextran-alpha-glucan graft copolymers and derivatives thereof

Disclosed herein are compositions comprising at least one alpha-glucan graft copolymer derivative compound (e.g., ether or ester) having a degree of substitution (DoS) up to about 3.0. The precursors of these derivative compounds are graft copolymers that comprise a dextran backbone and alpha-glucan side chains. At least about 30% of the glycosidic linkages of the alpha-glucan side chains are alpha-1,3 glycosidic linkages. Further disclosed are methods of producing graft copolymer derivatives, as well as their use in various applications and products.

Pharmaceutical compositions of active agents and cationic dextran polymer derivatives

Solid dry powder compositions comprising active agents and dextran polymer derivatives comprising an ester-linked amine-containing substituent and an alkyl ester substituent are disclosed, as are methods for making such compositions.

Polysaccharide coatings for paper

FIELD: chemistry.SUBSTANCE: invention relates to compositions which can provide a fat- and oil-resistant coating for bases, especially cellulose, textile and polymer bases. Coating compositions contain a water-insoluble polymer α-(1,3→glucan) and/or dextran polymer and, optionally, other additives. Polymer α-(1,3→glucan) has 90 % or more α-1,3-glycoside bonds, weight ratio of less than 1 % α-1,3,6-glycosidic branch points and number-average degree of polymerisation from 55 to 10000. Dextran contains 87–91.5 % α-1,6-glycoside bonds, 0.1–1.2 % α-1,3-glycoside bonds, 0.1–0.7 % α-1,4-glycoside bonds, 7.7–8.6 % α-1,3,6-glycoside bonds and 0.4–1.7 % α-1,2,6-glycoside bonds or α-1,4,6-glycoside bonds. Weight-average molecular weight (Mw) of dextran is 50–200 million daltons, and z is the average radius of inertia of dextran is 200–280 nm.EFFECT: enabling improvement of oil- and oil-resistant properties of coatings.19 cl, 4 tbl РОССИЙСКАЯ ФЕДЕРАЦИЯ ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) (19) RU (11) (13) 2 729 250 C2 (51) МПК D21H 19/10 (2006.01) C09D 105/00 (2006.01) C09D 105/02 (2006.01) C09D 129/02 (2006.01) C08L 5/00 (2006.01) C08L 5/02 (2006.01) D21H 21/16 (2006.01) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК D21H 19/10 (2020.01); D21H 21/16 (2020.01); C08L 5/00 (2020.01); C08L 5/02 (2020.01); C09D 105/00 (2020.01); C09D 105/02 (2020.01); D06M 15/03 (2020.01) (21)(22) Заявка: 2018115392, 24.10.2016 24.10.2016 (73) Патентообладатель(и): ДЮПОН ИНДАСТРИАЛ БАЙОСАЙЕНСИЗ ЮЭсЭй, ЭлЭлСи (US) Дата регистрации: 05.08.2020 26.10.2015 US 62/246,349; 05.11.2015 US 62/251,191 (43) Дата публикации заявки: 28.11.2019 Бюл. № 34 (45) Опубликовано: 05.08.2020 Бюл. № 22 C 2 C 2 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 28.05.2018 (86) Заявка PCT: US 2016/058436 (24.10.2016) 2 7 2 9 2 5 0 (87) Публикация заявки PCT: R U 2 7 2 9 2 5 0 (56) Список документов, цитированных в отчете о поиске: WO 2015/094402 A1, 25.06.2015. CN 103992978 A, 20.08.2014. US 2014 ...

Poly-alpha-1,3-1,6-glucans for viscosity modification

Compositions are disclosed herein comprising poly alpha-1,3-1,6-glucan with a weight average degree of polymerization (DPw) of at least 1000. This glucan polymer comprises at least 30% alpha-1,3 linkages and at least 30% alpha-1,6 linkages. Further disclosed are glucosyltransferase enzymes that synthesize poly alpha-1,3-1,6-glucan. Ether derivatives of poly alpha-1,3-1,6-glucan and methods of using such derivatives as viscosity modifiers are also disclosed.

Composition containing PEDOT:Dextran Copolymer and Its Manufacturing Method

본 발명은 폴리(3,4-에틸렌디옥시티오펜)(poly(3,4-ethylenedioxythiophene); PEDOT) 중합체를 포함하는 조성물 및 그 제조방법에 관한 것으로서, 소정의 산화제에 물(H 2 O)을 용매로 사용하고 3,4-에틸렌디옥시티오펜(3,4-ethylenedioxythiophene; EDOT)과 덱스트란 설페이트(Dextran Sulfate)를 도입하여 생성되는 수분산성 전도성 고분자인 폴리(3,4-에틸렌디옥시티오펜):덱스트란(PEDOT:Dextran) 공중합체를 포함하는 조성물 및 그 제조방법에 관한 것이다. 보다 더 상세하게 본 발명에 의하면, 물(H 2 O) 용매 하에서 하기 화학식 1의 3,4-에틸렌디옥시티오펜(3,4-ethylenedioxythiophene; EDOT)에 하기 화학식 4의 덱스트란 설페이트(Dextran Sulfate)를 폴리음이온으로 적용하고, 산화제로 산화중합시킨 후, 상기 산화 중합에 의한 반응 혼합물을 이혼교환수지로 처리해줌으로써 생성되는 폴리(3,4-에틸렌디옥시티오펜)-덱스트란(PEDOT:Dextran) 공중합체를 포함하는 조성물을 제공한다. (화학식 1) (화학식 4) The present invention relates to a composition comprising a poly (3,4-ethylenedioxythiophene) (PEDOT) polymer and a method for preparing the same, wherein water (H 2 O) is added to a predetermined oxidizing agent. Poly (3,4-ethylenedioxythiophene), a water-dispersible conductive polymer that is used as a solvent and is produced by introducing 3,4-ethylenedioxythiophene (EDOT) and dextran sulfate. The present invention relates to a composition comprising a dextran (PEDOT: Dextran) copolymer and a method for producing the same. In more detail, according to the present invention, 3,4-ethylenedioxythiophene (EDOT) of the following Chemical Formula 1 in water (H 2 O) solvent Dextran sulfate (Dextran Sulfate) Poly (3,4-ethylenedioxythiophene) -dextran (PEDOT) air produced by applying polyanion as a polyanion, oxidatively polymerizing with an oxidizing agent, and then treating the reaction mixture by oxidative polymerization with a dimerization resin. Provided is a composition comprising coalescing. (Formula 1) (Formula 4)