Настройки

Укажите год
-

Небесная энциклопедия

Космические корабли и станции, автоматические КА и методы их проектирования, бортовые комплексы управления, системы и средства жизнеобеспечения, особенности технологии производства ракетно-космических систем

Подробнее
-

Мониторинг СМИ

Мониторинг СМИ и социальных сетей. Сканирование интернета, новостных сайтов, специализированных контентных площадок на базе мессенджеров. Гибкие настройки фильтров и первоначальных источников.

Подробнее

Форма поиска

Поддерживает ввод нескольких поисковых фраз (по одной на строку). При поиске обеспечивает поддержку морфологии русского и английского языка
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Ведите корректный номера.
Укажите год
Укажите год
Применить Всего найдено 3287. Отображено 100.
19-01-2012 дата публикации

Size segregated aerosol mass concentration measurement with inlet conditioners and multiple detectors

Номер: US20120012744A1
Автор: Anthony E. Hase, David A. Lieder, George John Chancellor, James E. Farnsworth, James Evanstad, Jugal K. Agarwal, Sreenath Avula, Xiaoliang Wang
Принадлежит: TSI Inc

A system for measuring size segregated mass concentration of an aerosol. The system includes an electromagnetic radiation source with beam-shaping optics for generation of a beam of electromagnetic radiation, an inlet sample conditioner with adjustable cut-size that selects particles of a specific size range, and an inlet nozzle for passage of an aerosol flow stream. The aerosol flow stream contains particles intersecting the beam of electromagnetic radiation to define an interrogation volume, and scatters the electromagnetic radiation from the interrogation volume. The system also includes a detector for detection of the scattered electromagnetic radiation an integrated signal conditioner coupled to the detector and generating a photometric output, and a processor coupled with the conditioner for conversion of the photometric output and cut-size to a size segregated mass distribution.

Подробнее
Номер записи: 1
12-04-2012 дата публикации

Oil state monitoring method and oil state monitoring device

Номер: US20120086942A1
Автор: Akira Sasaki, Tomomi Honda, Yoshiro Iwai
Принадлежит: University of Fukui NUC

Disclosed are an oil state monitoring method and an oil state monitoring device which monitor the state of degradation of oil used in machinery or equipment. In monitoring the oil state by the oil state monitoring method and by the oil state monitoring device, oil used in machinery or equipment is filtered when the degradation state of the aforementioned oil is to be monitored. By means of filtration, the oil content is removed from the filter which captured contaminants that were present in oil prior to filtration. Light is projected onto the filter from which oil was removed. The projected light detects the color components of the transmitted light which penetrated the aforementioned filter.

Подробнее
Номер записи: 2
19-07-2012 дата публикации

Multiple laminar flow-based particle and cellular separation with laser steering

Номер: US20120183947A1
Автор: Amy Anderson, Daniel Mueth, Jessica Shireman, Joseph Plewa, Lewis Gruber, Neil Harris Rosenbaum
Принадлежит: Arryx Inc

The invention provides a method, apparatus and system for separating cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One exemplary method includes providing a first flow having a plurality of components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first cellular component of the plurality of components into the second flow while concurrently maintaining a second cellular component of the plurality of components in the first flow. The second flow having the first cellular component is then differentially removed from the first flow having the second cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

Подробнее
Номер записи: 3
22-11-2012 дата публикации

Sorting of adherent cells by selective transformation of labels

Номер: US20120295798A1
Автор: Frank Hsiung, Paul Patt, Robert M. Archer
Принадлежит: Bio Rad Laboratories Inc

Adherent cells bearing characteristics that are detectable only in the adherent state can be sorted on the basis of these characteristics independently of their adherent state, by applying a transformable label to the entire population of cells, both those bearing the characteristics of interest and those not, in their adherent state and identifying the locations of the cells of interest on the adherent surface. The cells of interest, or all cells other than those of interest, are then selectively treated to transform the labels and achieve differentiation between the cells of interest and the remaining cells. All cells are then released from the adherent state and sorted in the same manner as non-adherent cells but on the basis of whether the labels are transformed or not transformed.

Подробнее
Номер записи: 4
13-02-2014 дата публикации

Centrifugal particle separation and detection device

Номер: US20140045249A1
Автор: Chih-Chung Chen, Da-Jeng Yao
Принадлежит: National Tsing Hua University NTHU

The present invention provides a centrifugal particle separation and detection device, which can separate and detect particles according to the particle size. The centrifugal particle separate and detection device is practiced with a centrifuge to separate particles, and can be applied to cancer cell detection, blood lymphocyte isolation, tissue engineering, polynucleotide hybridization, microorganism separation and detection and fine chemical purification.

Подробнее
Номер записи: 5
13-03-2014 дата публикации

Microstructure for Particle and Cell Separation, Identification, Sorting, and Manipulation

Номер: US20140072952A1
Автор: George Hvichia
Принадлежит: Parsortix Inc

The invention relates to microscale cell separating apparatus which are able to separate cells on the basis of size of the cells, interaction of the cells with surfaces of the apparatus, or both. The apparatus comprises a stepped or sloped separation element ( 16 ) interposed between an inlet region ( 20 ) and an outlet region ( 22 ) of a void that can be tilled with fluid. The void can be enclosed within a cover ( 12 ) and fluid flow through the void engages cells with the separation element. Only cells which have (or can deform to have) a characteristic dimension smaller than or equal to the distance between a step and the cover or body can pass onto or past a step. Modifications of surfaces within the apparatus can also inhibit passage of cells onto or past a step.

Подробнее
Номер записи: 6
07-01-2021 дата публикации

Particle separation

Номер: US20210001337A1
Автор: Alexander Govyadinov, Erik D. Torniainen, Pavel Kornilovich, Viktor Shkolnikov
Принадлежит: Hewlett Packard Development Co LP

An example system includes an input channel having a first end and a second end to receive particles through the first end, a separation chamber, at least two output channels, and an integrated pump to facilitate flow through the separation chamber. The separation chamber is in fluid communication with the second end of the input channel. The separation chamber has a passive separation structure, the passive separation structure including an array of columns spaced apart to facilitate separation of particles in a flow based on a size of the particles. Each output channel is in fluid communication with the separation chamber to receive separated particles. The integrated pump is positioned within at least one of the input channel or one of the at least two output channels.

Подробнее
Номер записи: 7
05-01-2017 дата публикации

System and methods for estimation of mechanical properties and size of light-scattering particles in materials

Номер: US20170003271A1
Автор: Seemantinin K. Nadkarmi, Zelnab Hajjarian
Принадлежит: General Hospital Corp

System and method for determining a viscoelastic modulus of a sample with the use of optical data and an average size of light-scattering particles, of such sample, that has been derived from the optical data in reliance of angular dependence of a radiant flux profile determined from laser speckles formed by the sample and, in required, on a refractive index mismatch between light-scattering particles and sample medium hosting such particles. The determination is optionally carried out by taking into account at least one of absorption coefficient and reduced scattering coefficient of the sample, which are also determined from the same optical data. Laser speckle may be formed for different combinations of polarization states of sample-illuminating light and detected light and/or different wavelengths to account for polydisperse nature of the sample.

Подробнее
Номер записи: 8
13-01-2022 дата публикации

Particle characterization using optical microscopy

Номер: US20220012456A1
Автор: Clemens Kaminski, Kadi Liis SAAR, Oliver Vanderpoorten, Pavan Kumar Challa, Quentin Alexis Peter, Tuomas Pertti Jonathan Knowles
Принадлежит: CAMBRIDGE ENTERPRISE LTD

A method of optically characterizing individual molecules/molecular complexes, or other particles, in solution. The method comprises flowing a solution comprising the molecules/molecular complexes into an imaging region of a microfluidic channel, wherein the imaging region of the microfluidic channel has a first lateral dimension of greater than 1 μm in an x-direction wherein the x-direction is perpendicular to a direction of the flow; capturing a succession of images of the individual molecules/molecular complexes in the imaging region; tracking movement of the individual molecules/molecular complexes in at least the x-direction in the imaging region using the succession of images; and characterizing the individual molecules/molecular complexes from the tracked movement. In some implementations the characterizing comprises determining a diffusion coefficient of the molecules/molecular complexes from the tracked movement.

Подробнее
Номер записи: 9
07-01-2021 дата публикации

Real-time detection of particulate matter during deposition chamber manufacturing

Номер: US20210005436A1
Автор: Kyle Ross Tantiwong, Mehdi Vaez-Iravani, Todd J. Egan
Принадлежит: Applied Materials Inc

Implementations disclosed describe a system that includes a deposition chamber, a light source to produce an incident beam of light, wherein the incident beam of light is to illuminate a region of the deposition chamber, and a camera to collect a scattered light originating from the illuminated region of the deposition chamber, wherein the scattered light is to be produced upon interaction of the first incident beam of light with particles inside the illuminated region of the deposition chamber. The described system may optionally have a processing device, coupled to the camera, to generate scattering data for a plurality of locations of the illuminated region, wherein the scattering data for each location comprises intensity of the scattered light originating from this location.

Подробнее
Номер записи: 10
12-01-2017 дата публикации

Sequencing of nucleic acids via barcoding in discrete entities

Номер: US20170009274A1
Автор: Adam R. Abate, Adam R. SCIAMBI, Freeman Lan, John Halliburton
Принадлежит: UNIVERSITY OF CALIFORNIA

Microfluidic methods for barcoding nucleic acid target molecules to be analyzed, e.g., via nucleic acid sequencing techniques, are provided. Also provided are microfluidic, droplet-based methods of preparing nucleic acid barcodes for use in various barcoding applications. The methods described herein facilitate high-throughput sequencing of nucleic acid target molecules as well as single cell and single virus genomic, transcriptomic, and/or proteomic analysis/profiling. Systems and devices for practicing the subject methods are also provided.

Подробнее
Номер записи: 11
12-01-2017 дата публикации

METHOD AND DEVICE FOR DETERMINING CHARACTERISTIC PROPERTIES OF A TRANSPARENT PARTICLE

Номер: US20170010197A1
Автор: SCHAEFER Walter, TROPEA Cameron
Принадлежит:

The invention relates to a method for determining the size d of a transparent particle, according to which method the particle is illuminated with light from a light source, a radiation detector measures a time-resolved intensity profile of light of the light source scattered by the particle, a reflection peak () and a refraction peak are determined in the intensity profile and the size d of the particle is determined based on a time difference between the reflection peak () and the refraction peak. The method according to the invention is characterized in that the time-resolved intensity profile is measured at a definable scattering angle θs, a first second-order refraction peak () and a second second-order refraction peak () having a mode different from that of the first refraction peak () being determined, a characteristic variable γ being determined as the ratio of a first time difference Δtbetween the reflection peak () and the first refraction peak () and of a second time difference Δtbetween the reflection peak () and the second refraction peak (), and the size of only those particles being determined for which the characteristic variable γ corresponds to a definable value. 1. A method for determining characteristic properties of a transparent particle , wherein the particle is illuminated with light from a light source , wherein a time-resolved intensity profile of light from the light source that is scattered at the particle is measured by a radiation detector at a predefinable scattering angle θ , wherein characteristic scattered light peaks are determined in the intensity profile , and wherein a size of the particle is determined based on a time difference between two scattered light peaks ,wherein a first time difference is determined between a first pair of scattered light peaks and a second time difference is determined between a second pair of scattered light peaks, a characteristic variable is determined from the ratio of the first time difference ...

Подробнее
Номер записи: 12
12-01-2017 дата публикации

Method for calibrating apparatus for measuring shape factor

Номер: US20170010198A1
Автор: Jondahl Davis, Robert J. Pruett, Roger Wygant
Принадлежит: Imerys USA Inc

A method for calibrating an apparatus for measuring shape factor is provided, wherein the method comprises determining aspect ratios for each of a plurality of kaolin samples and measuring the shape factors of each of the plurality of kaolin samples using the apparatus, wherein each of the kaolin samples includes potassium oxide in an amount less than about 0.1% by weight of each of the kaolin samples. The method further includes calibrating the apparatus based on a correlation between the aspect ratios and the shape factors.

Подробнее
Номер записи: 13
17-01-2019 дата публикации

Microfluidic Device And Method For Detecting Rare Cells

Номер: US20190017919A1
Автор: Baez Lianette Rivera, Lin Eric, Nagrath Sunitha, Simeone Diane M., Wicha Max S., Yoon Hyeun Joong
Принадлежит: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (F) and Dean flow (F) of the fluid sample is from 2 to 10. 117-. (canceled)18. A microfluidic device for detecting rare cells in a fluid sample comprising the rare cells and other cells , the microfluidic device comprising:an inlet for receiving the fluid sample;a labyrinth channel structure in fluid communication with the inlet, wherein the labyrinth channel structure comprises at least one channel having a rectangular cross-section, a width of from 500 to 1000 μm, and a height of from 1 to 150 μm, the at least one channel having a plurality of segments and a plurality of corners with each corner defined between adjacent segments, wherein the plurality of corners are configured to induce a change in fluid flow direction of the fluid sample and a separation of the rare cells from the other cells in the fluid sample; andan outlet in fluid communication with the at least one channel for collecting the rare cells separated from the other cells in the fluid sample.19. The microfluidic device of claim 18 , wherein the labyrinth channel structure comprises at least 2 corners.20. The microfluidic device of ...

Подробнее
Номер записи: 14
21-01-2021 дата публикации

POWDER PARTICLE SIZE DISTRIBUTION MEASURING EQUIPMENT, POWDER DISPERSING DEVICE, AND METHOD OF MEASURING POWDER PARTICLE SIZE DISTRIBUTION

Номер: US20210018419A1
Автор: CHEN Chia-Chung, TU Shang-Te
Принадлежит:

A powder dispersing device of a powder particle size distribution measuring equipment has a base, an elastic force generating assembly and a first housing. The elastic force generating assembly includes a bumping piece, a force applying board and a power transmission assembly. Two ends of the power transmission assembly are respectively connected to the bumping piece and the force applying board. When the force applying board is applied with a first displacement, the power transmission assembly actuates the bumping piece to generate a second displacement which enables the bumping piece to have a first elastic force. The first housing is formed with a through hole on a side surface for one end of the force applying board to extend out. The first elastic force of the bumping piece triggers the bumping piece to strike on any surface facing toward the inside of the first housing and touching the other end of the bumping piece. 1. A powder dispersing device of a powder particle size distribution measuring equipment , comprising:a base; at least one bumping piece having one end and the other end,', 'at least one force applying board having one end and the other end, and a power transmission assembly having one end connected to the one end of the bumping piece and the other end connected to the one end of the force applying board, wherein a first displacement applied to the force applying board enables the power transmission assembly to actuate the bumping piece to generate a second displacement which enables the bumping piece to have a first elastic force; and, 'an elastic force generating assembly mounted on the base, comprisinga first housing having one end coupled with the base and having a side surface formed with a through hole, wherein the elastic force generating assembly is covered inside the first housing and the other end of the force applying board extends out the through hole;wherein the first elastic force triggers the bumping piece to strike on a plane ...

Подробнее
Номер записи: 15
25-01-2018 дата публикации

Direct Bond Transfer Layers for Manufacturable Sealing of Microfluidic Chips

Номер: US20180021774A1
Автор: Smith Joshua T., Tsang Cornelia K., Wang Chao, Wunsch Benjamin H.
Принадлежит:

Techniques for use of wafer bonding techniques for sealing of microfluidic chips are provided. In one aspect, a wafer bonding sealing method includes the steps of: forming a first oxide layer coating surfaces of a first wafer, the first wafer having at least one fluidic chip; forming a second oxide layer on a second wafer; and bonding the first wafer to the second wafer via an oxide-to-oxide bond between the first oxide layer and the second oxide layer to form a bonded wafer pair, wherein the second oxide layer seals the at least one fluidic chip on the first wafer. The second wafer can be at least partially removed after performing the bonding, and fluidic ports may be formed in the second oxide layer. A fluidic chip device is also provided. 1. A device , comprising:a first oxide layer coating surfaces of a first wafer, the first wafer comprising at least one fluidic chip; anda second oxide layer bonded to the first oxide layer via an oxide-to-oxide bond, wherein the second oxide layer seals the at least one fluidic chip on the first wafer.2. The device of claim 1 , wherein the at least one fluidic chip includes fluidic channels joined by nanochannel structures.3. The device of claim 2 , wherein each of the nanochannel structures comprises a pillar array for particle sorting.4. The device of claim 3 , wherein the pillar array comprises a plurality of pillars patterned in the first wafer.5. The device of claim 4 , wherein the first oxide layer is a thin conformal oxide layer covering a top and sidewall surfaces of the pillars.6. The device of claim 5 , wherein the second oxide layer is bonded to the pillar array via the thin conformal oxide layer.7. The device of claim 5 , wherein the second oxide layer is bonded to the thin conformal oxide layer at the top surface of the pillars.8. The device of claim 2 , wherein the fluidic channels comprise microchannels.9. The device of claim 8 , further comprising:fluidic ports formed in the second oxide layer at opposite ends ...

Подробнее
Номер записи: 16
24-01-2019 дата публикации

Particle detection system and method

Номер: US20190025165A1
Автор: David Blackford, Derek Oberreit, Patricia B. KEADY, Siqin He
Принадлежит: Kanomax Fmt Inc

A particle detector for rapidly detecting and identifying sub 20 nm particles in Ultra Pure Water (UPW) is disclosed. The detector has a nano particle extractor, a nanoparticle collector, and a tracer particle introducer. The extractor limits the size of droplets output to a predetermined size. The extractor includes (1) a liquid sample inlet, (2) a nebulizer connected to the liquid sample inlet (the nebulizer has a gas supply, and an outlet), (3) an impactor arranged to receive material output from the nebulizer, (4) an evaporator connected to the nebulizer and impactor for providing an aerosol at the extractor outlet, and (5) an aerosol connected to the evaporator. The collector us connected to the extractor and has: (1) a collector inlet connected to the aerosol outlet of the extractor, (2) a vapor condensation growth tube connected to the collector inlet, and (3) a repositionable particle capture plate arranged to receive material output from the growth tube at spatially varying positions. The tracer particle introducer is connected to the liquid sample inlet of the extractor. It includes a tracer particle supply connected to a pump which is connected to the extractor. A method for rapid identification of sub −20 nm particles in UPW is also disclosed.

Подробнее
Номер записи: 17
24-01-2019 дата публикации

METHOD OF AND SYSTEM FOR DETERMINING TEXTURIZATION OF ROVINGS

Номер: US20190025181A1
Автор: Clites Mark A., Herreman Kevin, Jousten Ralph, Korwin-Edson Michelle, Mouret Stephane, Trasser Frank
Принадлежит: OCV Intellectual Capital, LLC

Methods of and systems for quantifying a degree of texturization of fibrous materials, such as muffler fill materials, are disclosed. 1. A method of quantifying a degree of texturization of a fibrous material , the method comprising:providing a quantity of the fibrous material in a chamber;introducing air into the chamber at a predetermine flow rate;measuring a drop in pressure across the fibrous material at the flow rate;using the drop in pressure to calculate an effective fiber diameter of the fibrous material; andusing the effective fiber diameter to determine the degree of texturization of the fibrous material,wherein the degree of texturization is expressed as a ratio of an actual fiber diameter of the fibrous material to the effective fiber diameter of the fibrous material.2. (canceled)3. The method of claim 1 , wherein the degree of texturization is expressed as a percentage calculated by multiplying the ratio by 100.4. The method of claim 1 , wherein the actual fiber diameter is within the range of 8 μm to 40 μm.5. The method of claim 1 , wherein the chamber is one of a production muffler and a reference muffler.6. The method of claim 1 , wherein the fibrous material is texturized fiberglass.7. The method of claim 6 , wherein the texturized fiberglass is formed by feeding a fiberglass roving through a texturizing nozzle.8. The method of claim 1 , further comprising:feeding a fiberglass roving through a texturizing nozzle to form the fibrous material within a cavity of a muffler; andrelocating at least a portion of the fibrous material from the cavity to the chamber.9. The method of claim 1 , wherein the quantity of the fibrous material in the chamber has a fill density within the range of 80 g/L to 200 g/L.11. The system of claim 10 , wherein the first means is one of a production muffler and a reference muffler.12. The system of claim 10 , wherein the second means comprises a vacuum pump claim 10 , a flow valve claim 10 , and a flow meter.13. The system of ...

Подробнее
Номер записи: 18
23-01-2020 дата публикации

Method and apparatus for determining particle characteristics utilizing a plurality of beam splitting functions and correction of scattered light

Номер: US20200025665A1
Автор: Michael Trainer
Принадлежит: Individual

Apparatus and methods for determining information about at least one particle by measuring light scattered from the particles. Scattered light is combined with light from a light source to produce an optical interference signal utilizing a plurality of beam splitting functions. Scattered light signals are corrected for signal components which are not derived from particle scatter.

Подробнее
Номер записи: 19
02-02-2017 дата публикации

FAST THERMO-OPTICAL PARTICLE CHARACTERISATION

Номер: US20170030921A1
Автор: BAASKE Philipp, DUHR Stefan
Принадлежит: Nano Temper Technologies GmbH

The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) of individual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius). 1. Method to measure thermo-optically characteristics of particles in a solution with the steps of:providing a sample probe with marked particles in a solution;exciting fluorescently said marked particles and firstly detecting fluorescence of said excited particles;irradiating a laser light beam into the solution to obtain a spatial temperature distribution in the solution around the irradiated laser light beam;detecting secondly a fluorescence of the particles in the solution at a predetermined time after irradiation of the laser into the solution has been started, andcharacterizing the particles based on said two detections.2. The method according claim 1 , wherein the predetermined time is within the range of 1 ms to 250 ms3. The method according to or claim 1 , wherein the detection time is in the range of 1 ms to 50 ms.4. The method according to claim 1 , or claim 1 , wherein the laser beam is defocused such that a temperature gradient within the temperature distribution is in the range of from 0.0 to 2K/μm claim 1 , preferably from 0.0 to 5K/μm.5. The method according to claim 4 , wherein the laser beam is irradiated through an optical element into the solution.6. The method according to claim 4 , wherein the optical element is a single lens.7. The method according to any of the preceding claims claim 4 , further comprising the step of measuring the temperature distribution in said solution around the ...

Подробнее
Номер записи: 20
01-02-2018 дата публикации

ULTRASONIC PARTICLE SIZE MEASUREMENT DEVICE AND ULTRASONIC MEASUREMENT DEVICE

Номер: US20180031464A1
Автор: NORISUYE Tomohisa
Принадлежит: National University Corporation Kyoto Institute of Technology

An ultrasonic particle size measurement device includes: a transducer for (i) receiving an ultrasonic pulse scattered after being emitted to a fine particle and (ii) generating a first scattering amplitude ψ; and a particle size calculating section for calculating a particle size of the fine particle by calculating an amplitude r and a phase θ in accordance with a real part and an imaginary part, respectively, of a second scattering amplitude ψ obtained by subjecting the first scattering amplitude ψ to a Fourier transform. 1. An ultrasonic particle size measurement device comprising:an ultrasonic wave receiver for (i) receiving an ultrasonic pulse scattered after being emitted to a fine particle sedimenting in a liquid and (ii) generating a first scattering amplitude ψ (t,T) based on a propagation time t of the ultrasonic pulse and an observation time T with respect to motion of the fine particle; anda particle size calculating section for (i) generating a second scattering amplitude ψ (f,T) obtained by subjecting the first scattering amplitude ψ (t,T) to a Fourier transform in a direction of the propagation time t, (ii) calculating an amplitude r (f,T) and a phase θ (f,T) in accordance with a real part and an imaginary part, respectively, of the second scattering amplitude ψ (f,T), and (iii) calculating a particle size of the fine particle in accordance with the amplitude r (f,T) and the phase θ (f,T).2. The ultrasonic particle size measurement device as set forth in claim 1 , wherein the particle size calculating section calculates a motion velocity of the fine particle in accordance with the amplitude r (f claim 1 ,T) and the phase θ (f claim 1 ,T) and calculates the particle size in accordance with the motion velocity.3. The ultrasonic particle size measurement device as set forth in claim 1 , wherein the particle size calculating section generates a complex correlation function in accordance with the amplitude r (f claim 1 ,T) and the phase θ (f claim 1 ,T) and ...

Подробнее
Номер записи: 21
30-01-2020 дата публикации

PARTICLE CHARACTERISATION

Номер: US20200033245A1
Автор: CORBETT Jason, MALM Alex
Принадлежит: Malvern Panalytical Limited

A method of characterising particles in a sample, comprising: obtaining a scattering measurement comprising a time series of measurements of scattered light from a detector, the scattered light produced by the interaction of an illuminating light beam with the sample; producing a corrected scattering measurement, comprising compensating for scattering contributions from contaminants by reducing a scattering intensity in at least some time periods of the scattering measurement; determining a particle characteristic from the corrected scattering measurement. 1. A method of characterising particles in a sample , comprising:obtaining a scattering measurement comprising a time series of measurements of scattered light from a detector, the scattered light produced by the interaction of an illuminating light beam with the sample;producing a corrected scattering measurement, comprising compensating for scattering contributions from contaminants by reducing a scattering intensity in at least some time periods of the scattering measurement;determining a particle characteristic from the corrected scattering measurement.2. The method of claim 1 , wherein reducing the scattering intensity comprises modifying a recorded scattering measurement3. The method of claim 1 , wherein reducing the scattering intensity comprises high-pass filtering the scattering measurement.4. The method of claim 1 , wherein reducing the scattering intensity comprises determining a contaminant parameter from the scattering measurement claim 1 , wherein the step of reducing the scattering intensity is responsive to the contaminant parameter.5. The method of claim 4 , wherein the contaminant parameter comprises a cut-off frequency for a filtering operation.6. The method of claim 4 , wherein determining the contaminant parameter comprises finding statistical outliers in spectral content of the scattering measurement.7. The method of claim 1 , wherein producing a corrected scattering measurement comprises ...

Подробнее
Номер записи: 22
30-01-2020 дата публикации

OPTICAL PARTICLE SENSOR AND SENSING METHOD

Номер: US20200033250A1
Автор: VAN DER SLUIS Paul
Принадлежит:

The invention provides an optical particle sensor which uses light sources of different first and second wavelengths. A first light source is used to detect light scattering and also to determine when a particle reaches a target positional area. In response to the particle being determined to reach the target positional area, a second light source is operated to provide a pulse of light, and light emitted from the particle in response to the pulse of light is detected by the same detector. 1. An optical particle sensor , comprising:an optical arrangement comprising at least first and second light sources of different first and second wavelengths;an optical detector for detecting light emitted from particles to be sensed or light from the light sources scattered by particles to be sensed; anda controller for controlling the operation of the first and second light sources, operate the first light source, and detect light scattering using the optical detector;', 'determine when a particle reaches a target positional area based analyzing the detected scattered light;', 'in response the particle being determined to reach the target positional area, operate the second light source with a drive signal which is at least 2 times the maximum permitted continuous drive signal to provide a pulse of light with a duty cycle of less than 20%; and', 'detect light emitted from the particle in response to the pulse of light using the same optical detector., 'wherein the controller is adapted to2. A sensor as claimed in claim 1 , wherein the optical detector comprises a single optical sensor for detecting the first and second wavelengths claim 1 , wherein the optical sensor has greater sensitivity to the first wavelength than to the second wavelength claim 1 , such as a maximum sensitivity at or adjacent the first wavelength.3. A sensor as claimed in claim 2 , further comprising a background level compensation circuit for reducing the response time for the optical detector to adapt to ...

Подробнее
Номер записи: 23
08-02-2018 дата публикации

THERMAL COMPENSATION

Номер: US20180038782A1
Автор: Corbett Jason Cecil William, LIGHTFOOT Nigel, POOLMAN Rhys, STRINGFELLOW David
Принадлежит: Malvern Instruments Limited

Method of characterizing particles suspended in a fluid dispersant by light diffraction, comprising: obtaining measurement data from a detector element, the detector element being arranged to measure the intensity of scattered light; identifying a measurement contribution arising from light scattered by inhomogeneities in the dispersant; processing the measurement data to remove or separate the measurement contribution arising from light scattered by inhomogeneities in the dispersant; calculating a particle size distribution from the processed measurement. The detector element is one of a plurality of detector elements from which the measurement data is obtained. The detector elements are arranged to measure the intensity of scattered light at a plurality of scattering angles, the plurality of scattering angles distributed over a plurality of angles about an illumination axis. Identifying a measurement contribution arising from light scattered by inhomogeneities in the dispersant comprises identifying measured scattered light that is asymmetric about the illumination axis. 2. (canceled)3. The method of claim 1 , wherein at least some of the plurality of scattering angles are alternately arranged between a first and second radial location about the illumination axis with increasing scattering angle.4. The method of claim 3 , wherein the first and second radial location about the scattering axis are separated by at least 90 degrees about the illumination axis.5. The method of claim 1 , wherein at least some of the detector elements are arranged with their centroids in a logarithmic series of scattering angles.6. The method of claim 1 , wherein obtaining a measurement comprises obtaining a time history of the intensity of scattered light from the detector element or the detector elements.7. The method of claim 6 , wherein identifying a measurement contribution arising from light scattered by inhomogeneities in the dispersant comprises identifying peaks in the ...

Подробнее
Номер записи: 24
24-02-2022 дата публикации

PARTICLE STANDARDS FOR REFLECTED LIGHT SCATTER MEASUREMENTS FROM DEGENERATE PARTICLE FOCI

Номер: US20220057316A1
Автор: ZHUKOV Alexander
Принадлежит:

A method of selecting a type of particle for use in standardisation and/or calibration of a flow cytometer. The method includes determining the location of two or more particle focal points of particles flowing through a cross section of a channel in the flow cytometer; for each type of particle, determining for each particle focal point, for a beam of light directed at a type of particle at said particle focal point from a first direction, the total intensity of light scattered along a second direction; determining the difference between the highest and lowest determined light intensities of the light intensities determined at the two or more particle focal points; and selecting a type of particle for which the difference between the highest and lowest determined light intensities at the two or more particle focal points is below a predetermined threshold. 1. A method of selecting a type of particle for use in standardization and/or calibration of a flow cytometer , the method comprising:(a) determining a location of two or more particle focal points of particles flowing through a cross section of a channel in the flow cytometer; (b1) for each particle focal point of the two or more particle focal points, determining, for a beam of light directed at a particle of said type at said particle focal point from a first direction, a total intensity of light scattered along a second direction, the second direction lying within 90 degrees of the first direction; and', '(b2) determining, for the type of particle, the difference between the highest and lowest determined light intensities of the light intensities determined at the two or more particle focal points; and, '(b) for each type of particle of two or more different types of particles(c) selecting a type of particle for which the difference between the highest and lowest determined light intensities of the light intensities determined at the two or more particle focal points is below a predetermined threshold.2. The ...

Подробнее
Номер записи: 25
18-02-2016 дата публикации

MEMS AEROSOL IMPACTOR

Номер: US20160047728A1
Автор: Anaraki Siavash Pourkamali, WILSON James C.
Принадлежит:

Embodiments of the invention include aerosol impactors comprising one or more micromechanical resonators. Impactors according to embodiments of the invention can provide size classification and/or concentration of aerosol particulate. Aerosol impactors can use an air flow device, such as a pump, to create a constant flow of air. Nozzles of varying diameters are used to separate particulate of varying sizes and the particles that pass through strike a measuring device. MEMS resonators can be integrated into arrays to provide mass sensitivity in a small, lightweight and cost effective package, which will effectively allow for the measurement of the mass of every micro/nanoscale particle landing on the surface. 1. A particle impactor comprising:a housing;a nozzle disposed within the housing that includes an aperture to allow for the passage of air through the housing; anda microelectromechanical systems (MEMS) resonator positioned within the housing near the nozzle to capture particles within the air flowing through the housing, wherein the particles are within a predetermined size group, and wherein the MEMS resonator has a resonant frequency that shifts when a particle impacts a portion of the resonator.2. The particle impactor as in claim 1 , wherein the MEMS resonator is one of a plurality of MEMS resonators disposed on an impactor surface positioned below the nozzle.3. The particle impactor as in claim 1 , wherein the particle impactor is powered by a battery.4. The particle impactor as in claim 1 , wherein the MEMS resonator is less than or equal to 400 jim2 in area.5. The particle impactor as in claim 1 , wherein the MEMS resonator is less than or equal to 10 pm2 in area.6. The particle impactor as in claim 1 , wherein the particle impactor has a volume less than or equal to 40 cm3.7. The particle impactor as in claim 1 , wherein the particle impactor has a volume less than or equal to 10 cm3.8. The particle impactor as in claim 1 , wherein:the nozzle is one of ...

Подробнее
Номер записи: 26
18-02-2016 дата публикации

Multiple laminar flow-based particle and cellular separation with laser steering

Номер: US20160047777A1
Автор: Amy Anderson, Daniel Mueth, Jessica Shireman, Joseph Plewa, Lewis Gruber, Neil Rosenbaum
Принадлежит: Premium Genetics UK Ltd

The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

Подробнее
Номер записи: 27
16-02-2017 дата публикации

METHOD AND DEVICE FOR DETERMINING THE SIZE OF A TRANSPARENT PARTICLE

Номер: US20170045434A1
Автор: SCHAEFER Walter, TROPEA Cameron
Принадлежит:

A method is described for determining the size of a transparent particle (), wherein the particle () is illuminated with light from a light source (), wherein using a radiation detector () a time-resolved intensity curve of light from the light source () scattered on the particle () is measured at a preselectable scattering angle θ, wherein characteristic scattered light peaks are determined in the intensity curve, and wherein the size of the particle () is determined on the basis of the time difference between two scattered light peaks, characterized in that, with the help of two radiation detectors () or light sources (), a first and a second time-resolved intensity curve of scattered light, scattered on the particle () in the forward direction, are measured; a transmission peak () and a reflection peak () are determined from the first intensity curve and from the second intensity curve; a first time difference between the transmission peaks () is determined, and a second time difference between the reflection peaks () is determined; a characteristic variable α is determined from the ratio of the first time difference and the second time difference; and a size determination is performed for the particles () for which the characteristic variable α corresponds to a preselectable value. (FIG. ) 1. A method for determining the size of a transparent particle , wherein the particle is illuminated with light from a light source , wherein a time-resolved intensity curve of light from the light source scattered on the particle is measured at a preselectable scattering angle θusing a radiation detector , wherein characteristic scattered light peaks are determined in the intensity curve , and wherein the size of the particle is determined on the basis of the time difference between two scattered light peaks , wherein either (i) a first and a second time-resolved intensity curve of light from the light source , scattered on the particle in the forward direction , is measured ...

Подробнее
Номер записи: 28
08-05-2014 дата публикации

Variable flow path width virtual impactor and particle detecting device

Номер: US20140123730A1
Автор: Hidekazu Takahashi, Shinsuke Yamasaki
Принадлежит: Azbil Corp

A virtual impactor includes a jet nozzle that jets, from a jet outlet, a gas that contains particles, an opposing nozzle that is disposed with a specific separation distance from the jet nozzle and draws in, as a secondary flow, from a vacuum inlet at one end portion, a portion of the gas that is jetted from the jet nozzle, and a variable mechanism that varies at least one of a width of the jet outlet, the specific distance, and a width of the vacuum inlet.

Подробнее
Номер записи: 29
14-02-2019 дата публикации

Laser speckle micro-rheology in characterization of biomechanical properties of tissues

Номер: US20190049354A1
Автор: Seemantini K. Nadkarni, Zeinab HAJJARIAN
Принадлежит: General Hospital Corp

Laser speckle microrheology is used to determine a mechanical property of a biological tissue, namely, an elastic modulus. Speckle frames may be acquired by illuminating a coherent light and capturing back-scattered rays in parallel and cross-polarized states with respect to illumination. The speckle frames may be analyzed temporally to obtain diffuse reflectance profiles (DRPs) for the parallel-polarized and cross-polarized states. A scattering characteristic of particles in the biological tissue may be determined based on the DRPs, and a displacement characteristic may be determined based at least in part on a speckle intensity autocorrelation function and the scattering characteristic. A size characteristic of scattering particles may be determined based on the DRP for the parallel polarization state. The mechanical property may be calculated using the displacement and size characteristics.

Подробнее
Номер записи: 30
25-02-2021 дата публикации

PARTICULATE OBSERVATION DEVICE AND PARTICULATE OBSERVATION METHOD

Номер: US20210055197A1
Автор: KATO Haruhisa, Matsuura Yusuke, NAKAMURA Ayako
Принадлежит: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

The purpose of the present invention is to provide a particulate observation device using light scattering, which includes a means for determining the three-dimensional position of a particle, and can measure an accurate particle size or impart various properties of same. The present invention is characterized by including a position determination means which captures, with an optical microscope, an image of light scattered from particles in a dispersion medium to which laser light is emitted, and determines a three-dimensional position of each particle from the obtained two dimensional image, wherein the position determination obtains two-dimensional coordinates along the two-dimensional image from luminescent point positions of the particles, and determines the depth position along a coordinate axis vertical to the two-dimensional image from the diameters of diffraction fringes of the luminescent points. 1. A particulate observation device that uses light scattering , comprising:an optical microscope unit that images light scattered from particles in a dispersion medium to which laser light is emitted; and a processing unit that determines a three-dimensional position for each of the particles from a two-dimensional image obtained by the optical microscope unit,wherein the optical microscope unit provides the two-dimensional image by considering bright spots having diffraction fringes to be the particles, andthe processing unit obtains, from bright spot positions of the particles, two-dimensional coordinates that follow the two-dimensional image, and determines, from a diameter of the diffraction fringes of the bright spots, a depth position along a coordinate axis perpendicular to the two-dimensional image.2. The particulate observation device according to claim 1 , wherein the processing unit determines a magnitude of Brownian motion of the particles from the three-dimensional position claim 1 , and provides a particle size from the magnitude.3. The particulate ...

Подробнее
Номер записи: 31
13-02-2020 дата публикации

AUTOMATIC ANALYSIS APPARATUS, AUTOMATIC ANALYSIS METHOD, AND STORAGE MEDIUM

Номер: US20200049606A1
Автор: Masumura Takahiro, Sugita Satoru, Tahara Hirotoshi
Принадлежит:

An automatic analysis apparatus includes a reaction vessel configured to contain a reaction liquid in which a measuring object and a reagent are mixed with each other, an irradiation unit configured to irradiate the reaction vessel with irradiation light as predetermined incident light polarization, a measurement unit configured to measure light emitted from the reaction vessel, and a processor configured to process a signal having a specific polarization component obtained from the measurement unit and to analyze the measuring object. The specific polarization component is determined based on the condition of the reaction liquid. 1. An automatic analysis apparatus comprising:a reaction vessel configured to contain a reaction liquid in which a measuring object and a reagent are mixed with each other;an irradiation unit configured to irradiate the reaction vessel with irradiation light as predetermined incident light polarization;a measurement unit configured to measure light emitted from the reaction vessel; anda processor configured to process a signal having a specific polarization component obtained from the measurement unit and to analyze the measuring object,wherein the specific polarization component is determined based on the condition of the reaction liquid.2. The automatic analysis apparatus according to wherein the measurement unit includes a polarization selector configured to select an arbitrary polarization component in the emitted light claim 1 , and a detector configured to measure the emitted light having an arbitrary polarization component claim 1 , andwherein the processor extracts and processes the signal having the specific polarization component from the arbitrary polarization component based on the condition of the reaction liquid.3. The automatic analysis apparatus according to claim 2 , wherein the incident light polarization is a linear polarization claim 2 , andwherein the arbitrary polarization component includes at least one of a ...

Подробнее
Номер записи: 32
15-05-2014 дата публикации

Localized dynamic light scattering system with doppler velocity measuring capability

Номер: US20140132943A1
Автор: Lidek Chou
Принадлежит: Individual

A localized dynamic light scattering measurement system includes a beam displacer for splitting an incident beam having two orthogonal linearly polarized beam components with slightly different frequencies into two orthogonal linearly polarized output beams focused onto an object to be measured. The beam displacer cooperates with an iris to collect and recombine scattering beams each reversely backscattered at 180 degrees from the object so as to form a signal beam, which is polarized by a polarizer to produce two polarization components, thereby generating a heterodyne interference signal associated with the polarization components. A signal processing unit obtains measurement data on the object based on power spectrum or autocorrelation data corresponding to the heterodyne interference signal.

Подробнее
Номер записи: 33
10-03-2022 дата публикации

Method of inspecting lubricating oil composition and method of producing lubricating oil composition

Номер: US20220074840A1
Автор: Hitomi KANE, Kunio Kondo, Ryuji Monden, Yasuyuki Sakaguchi
Принадлежит: Showa Denko KK

The invention provides a method of inspecting a lubricating oil composition and a method of producing a lubricating oil composition. The inspecting method is capable of stably reproducing wear resistance characteristics by using a relatively easy measuring method even in the case where the lubricating oil composition contains a fullerene. In the method of inspecting the lubricating oil composition, the particle size (r) of particles present in the lubricating oil composition containing a base oil and fullerene is measured, and the lubricating oil composition is sorted on the basis of a predetermined range of the particle size (r) set by the relationship between the measured value of the particle size (r) and the measured value of the wear coefficient of the lubricating oil composition.

Подробнее
Номер записи: 34
21-02-2019 дата публикации

REGULARLY ARRANGED SPHEROIDS HAVING EQUAL SIZES AND USE THEREOF

Номер: US20190055590A1
Автор: Harada Yui, Morodomi Yosuke, Teraishi Koji, Yonemitsu Yoshikazu
Принадлежит:

The object is to provide a screening method for evaluating a large number of candidate compounds with sufficient accuracy, which uses aligned spheroids having equal sizes. The object is achieved by a method for screening for a substance that acts on spheroid formation, which comprises the following steps: (1) the step of inoculating cells on a plate on which a plurality of wells are regularly arranged (well plate), wherein each of the wells has a lowly adsorptive bottom having a U-shaped section, at a density effective for formation of spheroid, and culturing the cells in the plurality of the wells; (2) the step of contacting the cells with a test substance; and (3) the step of observing whether the cells contacted with the test substance form a spheroid or not, and evaluating action of the test substance on spheroid formation on the basis of the observation result as an index. 1. A culture of cells supported by a plate on which a plurality of wells are regularly arranged (well plate) , wherein each of the wells contains not more than one of spheroid.2. The culture according to claim 1 , wherein the spheroids in the wells have equal sizes.3. The culture according to claim 1 , wherein each of the wells has a lowly adsorptive bottom having a U-shaped section.4. The culture according to claim 1 , wherein the well plate has 96 claim 1 , 384 claim 1 , or 1536 wells.5. The culture according to claim 1 , wherein the cells are cancerous cells.6. The culture according to claim 1 , which is for use in screening for a compound.7. The culture according to claim 6 , wherein the screening is for selecting a candidate compound of anticancer agent.8. The culture according to claim 1 , which is for use in elucidation of a mechanism of a condition or disease in which formation of spheroids is involved.9. The culture according to claim 8 , wherein the condition or disease in which formation of spheroids is involved is peritoneal dissemination.10. A method for screening for a substance ...

Подробнее
Номер записи: 35
01-03-2018 дата публикации

SIZE DISTRIBUTION DETERMINATION OF AEROSOLS USING HYPERSPECTRAL IMAGE TECHNOLOGY AND ANALYTICS

Номер: US20180058995A1
Автор: HAMANN HENDRIK F., Klein Levente, Schrott Alejandro G.
Принадлежит:

An aerosol distribution determining system is provided. The system includes a set of pairs. Each of the pairs includes a light emitter mounted to a black object for respectively emitting electromagnetic radiation and absorbing a portion of the electromagnetic radiation. The system further includes a hyperspectral imaging camera for capturing hyperspectral images of the electromagnetic radiation in an absence of and in a presence of an aerosol distribution. The system also includes a data processing system for determining at least one of a size, a vertical density distribution, and a shape of particles in the aerosol distribution based on information derived using the hyperspectral images. 1. An aerosol distribution determining system , comprising:a set of pairs, each of the pairs including a light emitter mounted to a black object for respectively emitting electromagnetic radiation and absorbing a portion of the electromagnetic radiation;a hyperspectral imaging camera for capturing hyperspectral images of the electromagnetic radiation in an absence of and in a presence of an aerosol distribution; anda data processing system for determining at least one of a size, a vertical density distribution, and a shape of particles in the aerosol distribution based on information derived using the hyperspectral images.2. The aerosol distribution determining system of claim 1 , further comprising a spectral response library formed from the hyperspectral images and defining a plurality of spectral responses claim 1 , each of the plurality of spectral responses corresponding to an exposure of any of the black objects to a respective one of a plurality of different reference aerosol distributions.3. The aerosol distribution determining system of claim 1 , wherein the data processing system uses each of the black objects as a reference point with respect to the hyperspectral imaging camera from which the at least one of the size claim 1 , the vertical density distribution claim 1 , ...

Подробнее
Номер записи: 36
04-03-2021 дата публикации

MULTI-ANGLE DYNAMIC LIGHT SCATTERING

Номер: US20210063295A1
Автор: CORBETT Jason, Hamilton Douglas
Принадлежит: Malvern Panalytical Limited

A method of determining particle size distribution from multi-angle dynamic light scattering data, comprising: obtaining a series of measured correlation functions g(θ) at scattering angles θ; and solving an equation comprising 2. The method of claim 1 , wherein the linear solver is NNLS claim 1 , and/or the non-linear solver is selected from Nelder-Mead simplex claim 1 , Levenberg-Marquardt and Gauss-Newton.3. The method of claim 1 , wherein the initial estimates for the scaling factors αto αare estimated by extrapolation of a correlation function to a zero-delay time (τ=0).4. The method of claim 1 , wherein the predefined exit tolerance is:a convergence criterion based the preceding residual, orthe predefined exit tolerance is an absolute residual threshold.5. The method of claim 1 , further comprising repeating the steps a) to e) for a different non-linear solver claim 1 , to determine which non-linear solver provides the smallest residual.6. The method of claim 1 , further comprising measuring a time history of scattered light intensity at each respective scattering angle claim 1 , θ claim 1 , and determining the correlation functions g(θ) for each scattering angle.8. The method of claim 7 , wherein the dynamic light scattering data is multi-angle data claim 7 , and each measurement time corresponds with a different measurement angle θ; or wherein the dynamic light scattering data is of single angle type claim 7 , and each measurement time i corresponds with the same measurement angle θ.9. (canceled)10. The method of claim 7 , wherein the computed noise contribution is based on the expected instrument response to a large particle in a scattering volume of the instrument; wherein the large particle is assumed to be at least 3 microns in diameter claim 7 , or at least 10 microns in diameter.12. The method of claim 7 , further comprising sequentially measuring a time history of scattered light intensity at each respective scattering angle claim 7 , θ claim 7 , and ...

Подробнее
Номер записи: 37
12-03-2015 дата публикации

Methods and apparatus to obtain suspended particle information

Номер: US20150070696A1
Автор: Carol Tanner, Steven Ruggiero
Принадлежит: University of Notre Dame

An apparatus for obtaining suspended particle information includes an optical array to divide light to a first path and a second path, a platform to orient a first and second container with either the first or second path, and a first and second photodetector to receive at least a direct illuminating component of the light of the first and second path after said light penetrates through the first and second container. A detector interface receives transmission signals from the first and second photodetectors of the direct illuminating component of the light after penetrating through the first and second container and a calculation engine computes the particle information based on a ratio of the received transmission signals.

Подробнее
Номер записи: 38
27-02-2020 дата публикации

PARTICULATE MATTER VELOCITY MEASUREMENT AND SIZE ESTIMATION USING PARALLEL SELF-MIXING SENSING

Номер: US20200064249A1
Автор: Momtahan Omid, Mutlu Mehmet, YAN Miaolei, Yeh Richard
Принадлежит:

An apparatus for particulate matter (PM) measurement includes a first light source to generate a first light beam and a second light source disposed at a first distance from the first light source to generate a second light beam in parallel to the first light beam to illuminate a PM. The apparatus further includes a first light detector to measure a first timing corresponding to a first self-mixing signal resulting from a reflection and/or back-scattering of the first light beam from a PM, and a second light detector to measure a second timing corresponding to a second self-mixing signal resulting from a reflection and/or back-scattering of the second light beam from the PM. A processor can determine a first velocity of the PM based on a spatial separation between centers of the first light beam and the second light beam and a temporal separation between the first timing and the second timing. 1. An apparatus for particulate matter (PM) spatial and temporal separation measurement , the apparatus comprising:a first light source configured to generate a first light beam to illuminate a PM;a second light source disposed at a first distance from the first light source and configured to generate a second light beam in parallel to the first light beam to illuminate the PM;a first light detector configured to measure a first timing corresponding to a first self-mixing signal resulting from at least one of a reflection or back scattering of the first light beam from a PM;a second light detector configured to measure a second timing corresponding to a second self-mixing signal resulting from at least one of a reflection or back scattering of the second light beam from the PM; anda processor configured to determine a first velocity of the PM based on a spatial separation between centers of the first light beam and the second light beam and a temporal separation between the first timing and the second timing.2. The apparatus of claim 1 , wherein the first light source and the ...

Подробнее
Номер записи: 39
07-03-2019 дата публикации

Micro-Fluidic Particle Concentrator and Filtering Device

Номер: US20190071627A1
Автор: Ludovic Serex
Принадлежит: Ecole Polytechnique Federale de Lausanne EPFL

A crossflow microfluidic particle concentrator including a main channel having an inlet and an outlet a crossflow outlet operably connectable with pressure means and/or flow control means, a plurality of crossflow channels fluidically connecting the crossflow outlet with the main channel a filtering element including a particle flow channel within the main channel, and a row of crossflow pillars disposed between the filtering element and the plurality of crossflow channels.

Подробнее
Номер записи: 40
24-03-2022 дата публикации

PARTICLE CHARACTERISATION

Номер: US20220091006A1
Автор: CORBETT Jason
Принадлежит: Malvern Panalytical Limited

An apparatus for particle characterisation, comprising: a sample cell for holding a sample; a light source configured to illuminate the sample with an illuminating beam and a plurality of light detectors, each light detector configured to receive scattered light resulting from the interaction between the illuminating beam and the sample along a respective detector path, wherein each respective detector path is at substantially the same angle to the illuminating beam. 1. An apparatus for particle characterisation , comprising:a sample cell for holding a sample;a plurality of light sources configured to illuminate the sample with a plurality of illuminating beams;a plurality of light detectors, each light detector configured to receive scattered light resulting from the interaction between an illuminating beam and the sample along a respective detector path, wherein each respective detector path is at substantially the same angle to the illuminating beam; and wherein the detector paths are arranged to respectively intersect with the illumination beams at a plurality of locations along the illumination beams;a plurality of optical fibres, each optical fibre corresponding with a light detector and arranged to couple light from the respective detector path to the corresponding light detector; wherein each optical fibre is arranged to receive the scattered light from the detector path at a first end portion;wherein the first end portions of each optical fibre comprise a two dimensional array of fibres.2. The apparatus of claim 1 , wherein the first end portions of each fibre are substantially parallel.3. The apparatus of claim 1 , wherein the first end portions of each fibre are oriented at different angles.4. The apparatus of claim 2 , further comprising one or more fibre support members.5. The apparatus of claim 4 , wherein the first end portions of the optical fibres are each supported by an array of “V” grooves in a fibre support member.6. The apparatus of claim 1 , ...

Подробнее
Номер записи: 41
24-03-2022 дата публикации

CONTACT-FREE HOLOGRAPHIC IMAGING OF AEROSOL PARTICLES FROM MOBILE PLATFORMS

Номер: US20220091019A1
Автор: Berg Matthew J., Kemppinen Osku P., Videen Gorden W.
Принадлежит:

A device includes a filter that enhances a beam profile of a received pulsed laser; a first optical element to direct the pulsed laser as a reference wave towards an optical sensor; an open cavity positioned between the first optical element and the optical sensor. The open cavity receives an aerosol particle, which enters the open cavity from any direction. The reference wave illuminates the aerosol particle. An illuminated particle generates and directs an object wave towards the optical sensor. A pixel array is connected to the optical sensor. The pixel array receives the reference wave and the object wave. The optical sensor creates a contrast hologram comprising an interference pattern of the illuminated particle. A processor creates an image of the illuminated particle based on the contrast hologram. 1. A device comprising:a filter that enhances a beam profile of a received pulsed laser;a first optical element to direct the pulsed laser as a reference wave towards an optical sensor;an open cavity positioned between the first optical element and the optical sensor, wherein the open cavity receives an aerosol particle, wherein the reference wave illuminates the aerosol particle, and wherein an illuminated particle generates and directs an object wave towards the optical sensor;a pixel array connected to the optical sensor, wherein the pixel array receives the reference wave and the object wave, and wherein the optical sensor creates a contrast hologram comprising an interference pattern of the illuminated particle; anda processor that creates an image of the illuminated particle based on the contrast hologram.2. The device of claim 1 , wherein the aerosol particle flows in the open cavity in a direction substantially transverse to the reference wave and from any direction in a plane perpendicular to a propagation direction of the reference wave.3. The device of claim 1 , comprising a second optical element to direct the pulsed laser from the filter.4. The device ...

Подробнее
Номер записи: 42
14-03-2019 дата публикации

PARTICLE CHARACTERISATION

Номер: US20190078990A1
Автор: CORBETT Jason
Принадлежит: Malvern Panalytical Limited

An apparatus for particle characterisation, comprising: a sample cell for holding a sample; a light source configured to illuminate the sample with an illuminating beam and a plurality of light detectors, each light detector configured to receive scattered light resulting from the interaction between the illuminating beam and the sample along a respective detector path, wherein each respective detector path is at substantially the same angle to the illuminating beam. 1. An apparatus for particle characterisation , comprising:a sample cell for holding a sample;a light source configured to illuminate the sample with an illuminating beam;a plurality of light detectors, each light detector configured to receive scattered light resulting from the interaction between the illuminating beam and the sample along a respective detector path, wherein each respective detector path is at substantially the same angle to the illuminating beam.2. The apparatus of claim 1 , further comprising:a plurality of optical fibres, each optical fibre corresponding with a light detector and arranged to couple light from the respective detector path to the corresponding light detector.3. The apparatus of claim 2 , wherein each optical fibre is arranged to receive the scattered light from the detector path at a first end portion; andwherein the first end portions of each fibre are substantially parallel.4. The apparatus of claim 3 , wherein the first end portions of each optical fibre comprise a one dimensional array of fibres.5. The apparatus of claim 3 , wherein the first end portions of each optical fibre comprise a two dimensional array of fibres.6. The apparatus of claim 2 , wherein each optical fibre is arranged to receive the scattered light from the detector path at a first end portion; andwherein the first end portions of each fibre are oriented at different angles.7. The apparatus of claim 3 , further comprising one or more fibre support members.8. The apparatus of claim 6 , wherein ...

Подробнее
Номер записи: 43
21-03-2019 дата публикации

CELL ANALYSIS METHOD, CELL INFORMATION PROVIDING APPARATUS, CELL INFORMATION PROVIDING SYSTEM

Номер: US20190086317A1
Автор: INOKUCHI Hiroaki, SHIRASUNA Kei
Принадлежит:

The method includes a counting step of counting, among cells included in a sample, a first cell number indicating the number of cells classified into a first group based on cell size and cell nucleus size and having a DNA amount greater than a threshold value, and a second cell number indicating the number of cells classified into a second group that is different from the first group based on the cell size and cell nucleus size and having a DNA amount greater than the threshold value; and a comparing step of comparing the first cell number with the second cell number. 1. A cell analysis method comprising:a counting step of counting, among cells included in a sample, a first cell number indicating the number of cells classified into a first group based on cell size and cell nucleus size and having a DNA amount greater than a threshold value, and a second cell number indicating the number of cells classified into a second group that is different from the first group based on the cell size and cell nucleus size and having a DNA amount greater than the threshold value; anda comparing step of comparing the first cell number with the second cell number.2. The cell analysis method according to claim 1 , wherein the counting step comprises classifying the cells included in the sample based on the cell size and the cell nucleus size so that cells on the surface layer side are included in the first group and cells on the basal side are included in the second group.3. The cell analyzing method according to claim 1 , wherein the counting step comprises classifying the cells included in the sample into the first group and the second group based on a ratio between the cell size and the cell nucleus size.4. The cell analysis method according to claim 3 , wherein the counting step comprises classifying the cells included in the sample into the first group and the second group by comparing the ratio with a second threshold value.5. The cell analysis method according to claim 1 , ...

Подробнее
Номер записи: 44
05-05-2022 дата публикации

SYSTEMS, ARTICLES, AND METHODS FOR FLOWING PARTICLES

Номер: US20220136949A1
Автор: Calistri Nicholas L., Kimmerling Robert J., Manalis Scott R., Olcum Selim, Stevens Mark M.
Принадлежит: Massachusetts Institute of Technology

Systems and methods for flowing particles, such as biological entities, in a fluidic channel(s) are generally provided. In some cases, the systems described herein are designed such that a single particle may be isolated from a plurality of particles and flowed into a fluidic channel (e.g., a microfluidic channel) and/or collected e.g., on fluidically isolated surfaces. For example, the single particle may be present in a plurality of particles of relatively high density and the single particle is flowed into a fluidic channel, such that it is separated from the plurality of particles. The particles may be spaced within a fluidic channel so that individual particles may be measured/observed over time. In certain embodiments, the particle may be a biological entity. Such article and methods may be useful, for example, for isolating single cells into individual wells of multi-well cell culture dishes (e.g., for single-cell analysis).

Подробнее
Номер записи: 45
04-04-2019 дата публикации

HOLOGRAPHIC METHOD FOR CHARACTERISING A PARTICLE IN A SAMPLE

Номер: US20190101482A1
Автор: ALI CHERIF Anais, Allier Cédric, BLANDIN Pierre, ESTEBAN Geoffrey, Herve Lionel, ISEBE Damien
Принадлежит:

A method for holographic characterization of a particle contained in a sample, based on an image, or hologram, of the sample obtained by an image sensor when the sample is illuminated by a light source. The hologram is the subject of a holographic reconstruction, to obtain a reference complex image, representative of the light wave transmitted by the sample in a reconstruction plane. A holographic propagation operator is applied to the reference complex image, to obtain a plurality of secondary complex images, from which a profile is determined describing the change in an optical feature of the light wave transmuted by the sample along the axis of propagation of the light wave. 115-. (canceled)16: A method for characterizing a particle combined in a sample , the method comprising:a) illuminating the sample using a light source, the light source emitting an incident light wave propagating towards the sample along a propagation axis;b) acquiring, using an image sensor, an image of the sample, formed in a detection plane, the sample being positioned between the light source and the image sensor, the image being representative of a light wave, transmitted by the sample under effect of the illumination;c) applying a propagation operator to the image acquired in b), to calculate a reference complex image, which is a complex image representative of the sample in a reconstruction plane:d) selecting a radial position of the particle in a plane parallel to the detection plane; ei) applying a propagation operator to the reference complex image, to calculate secondary complex images for a plurality of distances from the reconstruction plane or from the detection plane;', 'eii) determining a characteristic quantity of the light wave transmitted by the sample at each of the plurality of distances, from the secondary complex images;, 'e) from the reference complex image calculated in c), determining at least one characteristic quantity of the light wave transmitted by the sample, ...

Подробнее
Номер записи: 46
02-06-2022 дата публикации

Glittery ink and image forming device

Номер: US20220169879A1
Автор: Juichi Furukawa
Принадлежит: Ricoh Co Ltd

A glittery ink contains glittery pigment particles, resin particles, and an organic solvent, wherein the following relationships are satisfied: a≤c≤b and a<b, where a represents the particle diameter of the resin particles corresponding to the minimum of two or more peaks in a particle size distribution as measured by a dynamic light scattering particle size distribution measuring device, b represents the particle diameter of the resin particles corresponding to the maximum of the two or more peaks in the particle size distribution, and c represents the particle diameter of the glittery pigment corresponding to a maximum number of particles in a particle size distribution as measured by the dynamic light scattering particle size distribution measuring device.

Подробнее
Номер записи: 47
02-06-2022 дата публикации

FLUID COMPOSITION SENSOR DEVICE AND METHOD OF USING THE SAME

Номер: US20220170838A1
Автор: Brown Andy Walker, Lowery Steven, Myers Ronald W., Sorenson Richard Charles, Speldrich Jamie W.
Принадлежит:

Various embodiments are directed to a fluid composition sensor device and method of using the same. In various embodiments, the fluid flow composition sensor is configured to receive a volume of fluid, the fluid composition sensor comprising a housing, a removable fluid flow component, an impactor nozzle, a collection media assembly dock element configured to receive a replaceable collection media assembly comprising a collection media configured to receive one or more particles within the volume of fluid, an imaging device configured to capture an image of at least a portion of the one or more particles received by the fluid composition sensor, and a controller configured to determine, based at least in part on the image, at least one particle characteristic of the volume of fluid. The imaging device may be configured to capture the image of one or more particles received by the fluid composition sensor using lensless holography. 1. A device for detecting fluid particle characteristics comprising:a fluid composition sensor configured to receive a volume of fluid, the fluid composition sensor comprising:a removable fluid flow component disposed within an internal sensor portion and configured to define at least a portion of a fluid flow path;a collection media assembly dock element configured to receive a replaceable collection media assembly comprising a collection media configured to receive one or more particles of a plurality of particles within the volume of fluid and the replaceable collection media assembly is arranged within the internal sensor portion in a particle collection position; anda housing defining the internal sensor portion and being selectively configurable between an open housing configuration and a closed housing configuration, wherein when the housing is in the closed housing configuration, a vertical compression force is applied to the replaceable collection media assembly so as to at least partially constrain the replaceable collection ...

Подробнее
Номер записи: 48
29-04-2021 дата публикации

METHODS AND DEVICES FOR MEMS BASED PARTICULATE MATTER SENSORS

Номер: US20210123849A1
Автор: El-Gamal Mourad, Elsayed Mohannad, Singh Navpreet
Принадлежит:

Airborne pollutants from natural and man-made sources are an increasing where their aerodynamic properties determine how far into the human respiratory system they penetrate. International and national guidelines or regulatory limits specify limits for particulate matter (PM) at different particulate dimensions leading to a requirement for low cost compact PM detectors/sensors. A flow of known and desired size particles are separated and guided by a virtual impactor towards a microelectromechanical systems (MEMS) sensor, e.g. MEMS resonator, yielding the required PM detectors/sensors. Further, in conjunction with the virtual impactor and MEMS sensor additional elements are provided to exploit thermophoresis or di-electrophoresis such that the particles within the sensing area of the MEMS sensor can be removed. Accordingly, the MEMS sensor based particle detector/sensor can be periodically reset allowing for extended operational life of the MEMS sensor based particle detector/sensor and/or enhanced performance over extended periods. 1. A method of detecting particles comprising:providing a microelectromechanical systems (MEMS) resonator comprising a membrane, an electrode atop the membrane and at least a pair of anchors;exposing the MEMS resonator to a source of particles; anddetermining in dependence upon a shift in a characteristic of the MEMS resonator a mass of particles deposited upon the membrane; whereinthe MEMS resonator is driven; anda metal layer is patterned on top of the membrane to act as the top electrode, while the substrate acts as the bottom electrode (ground plane).2. The method according to claim 1 , further comprisingproviding a piezoelectric layer between the membrane and the electrode; whereinthe MEMS resonator is piezoelectrically driven.3. The method according to claim 1 , whereinthe portion is defined by those particles being below a predetermined maximum dimension where the maximum predetermined dimension is established in dependence upon ...

Подробнее
Номер записи: 49
02-04-2020 дата публикации

SUSPENSION PARTICLE SENSING APPARATUS

Номер: US20200103326A1
Автор: Chen Chih-Jen, Gu Guang-Huei, Lin Jing-Yuan
Принадлежит: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

A suspension particle sensing apparatus includes a first flow channel, a suspension particle concentration sensor and a suspension particle filtering assembly. The first flow channel has a first entrance and a first exit. The suspension particle concentration sensor is disposed in the first flow channel, and is located between the first entrance and the first exit. The suspension particle filtering assembly is disposed at the first entrance, and includes a casing and a suspension particle filtering structure. The casing has a first opening and a second opening. The first opening is communicated with the first entrance of the first flow channel. The suspension particle filtering structure covers the second opening. 1. A suspension particle sensing apparatus , comprising:a first flow channel, having a first entrance and a first exit;a suspension particle concentration sensor, disposed in the first flow channel, and located between the first entrance and the first exit; and a casing, having a first opening and a second opening, wherein the first opening is communicated with the first entrance of the first flow channel; and', 'a suspension particle filtering structure, covering the second opening., 'a suspension particle filtering assembly, disposed at the first entrance of the first flow channel, and comprising2. The suspension particle sensing apparatus as claimed in claim 1 , further comprising a vibrator claim 1 , disposed on a surface of the casing.3. The suspension particle sensing apparatus as claimed in claim 2 , wherein the vibrator comprises a vibration motor claim 2 , a piezoelectric microactuator or a combination thereof.4. The suspension particle sensing apparatus as claimed in claim 1 , further comprising a pumping system claim 1 , disposed at the first exit of the first flow channel.5. The suspension particle sensing apparatus as claimed in claim 1 , further comprising a second flow channel claim 1 , having a second entrance and a second exit claim 1 , ...

Подробнее
Номер записи: 50
28-04-2016 дата публикации

METHOD AND APPARATUS FOR A PORTABLE PM2.5 MONITORING DEVICE

Номер: US20160116390A1
Автор: TAN Zhongchao
Принадлежит:

The disclosure is directed at apparatus for portable PM2.5 monitoring including a PM2.5 sampling device including a housing portion for collecting and separating air-borne particulate matter, an inlet port, connected to the housing portion, for receiving the air-borne particulate matter, a core portion, located within the housing portion, the core portion assisting in generating a cyclonic airflow pattern to produce a uniflow system for separating particulate matter below a predetermined size from particulate matter above a predetermined size within the air-borne particulate matter, and an outlet port for receiving the particulate matter below the predetermined size; a particle counter, connected to the outlet port, for receiving the particulate matter smaller than the predetermined size and for determining a mass of the particulate matter below the predetermined size; and a processor for determining a PM2.5 level based on the mass of the particulate matter below the predetermined size. 1. A system for PM2.5 sampling comprising:an inlet port for receiving air-borne particulate matter;apparatus for creating a cyclonic airflow pattern within the system to produce a uniflow system to separate larger pieces of particulate matter from smaller pieces of particulate matter;an outlet port for receiving the smaller pieces of particulate matter;wherein the received smaller pieces of particulate matter are transmitted for further counting.2. An apparatus for PM2.5 sampling comprising:a housing portion for collecting and separating air-borne particulate matter;at least one inlet port, connected to the housing portion, for receiving the air-borne particulate matter;a core portion, located within the housing portion, the core portion assisting in generating a cyclonic airflow pattern to produce a uniflow system for separating particulate matter below a predetermined size from particulate matter above a predetermined size within the air-borne particulate matter; andan outlet port ...

Подробнее
Номер записи: 51
09-04-2020 дата публикации

Method for determining parameters of a particle

Номер: US20200110017A1
Автор: Cedric Allier, Lionel Herve, Pierre Joly
Принадлежит: Commissariat a lEnergie Atomique et aux Energies Alternatives CEA

A method for determining a parameter of a particle present in a sample, the method comprising the following steps: a) illuminating the sample with the light source, the light source emitting an incident light wave that propagates along a propagation axis; b) acquiring an image of the sample with the image sensor, the image sensor being exposed to an exposure light wave; c) determining a position of the particle in the detection plane; d) on the basis of the acquired image, applying a propagation operator, for a plurality of distances from a detection plane, so as to estimate, at each distance, a complex amplitude of the exposure light wave; e) on the basis of the complex amplitude estimated, at various distances, obtaining a profile representing a variation of the complex amplitude of the exposure light wave along an axis parallel to the propagation axis and passing through the position of the particle. The particle may associated with a set of parameters, comprising at least a size of the particle and a refractive index of the particle.

Подробнее
Номер записи: 52
07-05-2015 дата публикации

Fast thermo-optical particle characterisation

Номер: US20150125897A1
Автор: Philipp Baaske, Stefan Duhr
Принадлежит: Ludwig Maximilians Universitaet Muenchen LMU

The present invention relates to a method and an apparatus for a fast thermo-optical characterisation of particles. In particular, the present invention relates to a method and a device to measure the stability of (bio)molecules, the interaction of molecules, in particular biomolecules, with, e.g. further (bio)molecules, particularly modified (bio)molecules, particles, beads, and/or the determination of the length/size (e.g. hydrodynamic radius) ofindividual (bio)molecules, particles, beads and/or the determination of length/size (e.g. hydrodynamic radius).

Подробнее
Номер записи: 53
27-05-2021 дата публикации

DEPICTING OF OBJECTS

Номер: US20210156782A1
Автор: Holm Johan
Принадлежит:

A method for characterizing object(s) in a sample includes collecting transmitted, refracted, scattered, diffracted, and/or emitted light from the sample. The collected light formed on a sensor surface includes at least a first and second image of the object(s). For at least the first and second image, the collected light is modulated asymmetrically differently, or for at least a third and fourth image focal plane positions are different, or for at least a fifth image the collected light is modulated in at least two places differently compared to the surroundings, or for at least a sixth and seventh image of the object(s), the collected light is modulated asymmetrically differently and focal planes of the sixth and seventh image have different positions. The images are processed to characterize the objects(s). 1. A method for characterizing one or more objects in a sample , the method comprising the steps of:collecting transmitted, refracted, scattered, diffracted, and/or emitted light from the sample, including fluorescent and/or luminescent light, optionally using one or more lens(es), thus forming collected light, at least a first image and a second image of the object(s), wherein for at least the first and the second image the collected light is modulated asymmetrically differently, or', 'at least a third image and a fourth image of the object(s), wherein focal planes of the third image and of the fourth image have different positions, or', 'at least a fifth image of light of the object(s), wherein for at least the fifth image, the collected light is modulated in at least two places differently compared to the surroundings, or', 'at least a sixth image and a seventh image of the object(s), wherein for at least the sixth and the seventh image the collected light is modulated asymmetrically differently and focal planes of the sixth image and of the seventh image have different positions, and, 'forming by said collected light on a sensor surface'} the at least ...

Подробнее
Номер записи: 54
25-08-2022 дата публикации

DETERMINING VEHICLE OPERATING STATE BY PARTICLE DETECTION

Номер: US20220270498A1
Автор: Wienkes Lee R.
Принадлежит: HONEYWELL INTERNATIONAL INC.

A system for determining a vehicle operating state is provided. The system includes at least two particle detectors, a controller and a memory. A sample volume used by each particle detector of the at least two particle detectors configured to be collected in a different location relative to the vehicle than another sample volume used by another particle detector of the at least two particle detectors and at least one sample volume is configured to be collected in an environment where particles are disturbed by the vehicle. The controller is configured to determine at least one operating state of the vehicle based at least in part on a comparison of output signals of the at least two particle detectors. The at least one memory is used to store at least operating instructions implemented by the controller in determining the at least one operating state of the vehicle. 1. A system for determining a vehicle operating state , the system comprising:at least two particle detectors, a sample volume used by each particle detector of the at least two particle detectors configured to be collected in a different location relative to the vehicle than another sample volume used by another particle detector of the at least two particle detectors, wherein at least one sample volume is configured to be collected in an environment where particles being detected by an associated particle detector are disturbed by the vehicle when the vehicle is in motion;a controller in communication with the at least two particle detectors, the controller configured to determine at least one operating state of the vehicle based at least in part on a comparison of output signals of the at least two particle detectors; andat least one memory to store at least operating instructions implemented by the controller in determining the at least one operating state of the vehicle.2. The system of claim 1 , wherein the determined operating state is at least one of angle of attack claim 1 , side slip angle and ...

Подробнее
Номер записи: 55
25-04-2019 дата публикации

Detecting the Cleanness of Wafer after Post-CMP Cleaning

Номер: US20190122942A1
Автор: Chi-Ming Tsai, Hui-Chi Huang, Yu-Ting Yen
Принадлежит: Taiwan Semiconductor Manufacturing Co TSMC Ltd

A method includes performing Chemical Mechanical Polish (CMP) on a wafer, placing the wafer on a chuck, performing a post-CMP cleaning on the wafer, and determining cleanness of the wafer when the wafer is located on the chuck.

Подробнее
Номер записи: 56
10-05-2018 дата публикации

ANALYSIS APPARATUS

Номер: US20180128726A1
Автор: FU Wei-En, Ho Hsin-Chia, Lin Yen-Liang, Wang Sheng-Hann, Yeh Yu-Shan
Принадлежит: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTE

According to an embodiment of the present disclosure, an analysis apparatus may include a movable carrier, a sample providing device and a first analysis device. The movable carrier has at least one sample carry region, and moves the sample carry region to at least one collection position and an analysis position. The sample providing device provides a plurality of samples, wherein the sample carry region receives a portion of the samples at the collection position. The first analysis device may be aligned to the analysis position, and analyzes the samples on the sample carry region located at the analysis position. 1. An analysis apparatus , comprising:a movable carrier, comprising at least one sample carry region, and moving the sample carry region to at least one collection position and an analysis position;a sample providing device, providing a plurality of samples, wherein the sample carry region receives a portion of the samples at the collection position; anda first analysis device, aligned to the analysis position, and analyzing the samples on the sample carry region at the analysis position.2. The analysis apparatus according to claim 1 , wherein the sample providing device is a particle filtering device claim 1 , the particle filtering device performs filtering according to particle sizes of the samples and provides the filtered samples to the sample carry region.3. The analysis apparatus according to claim 1 , wherein the movable carrier rotates along a rotation axis to drive the sample carry region to move about the rotation axis to the collection position or the analysis position.4. The analysis apparatus according to claim 1 , wherein the movable carrier moves reciprocatingly along a translating axis to drive the sample carry region to move along the translating axis to the collection position or the analysis position.5. The analysis apparatus according to claim 1 , wherein the movable carrier further comprises at least one carry unit claim 1 , the ...

Подробнее
Номер записи: 57
11-05-2017 дата публикации

FEEDBACK CONTROL FOR IMPROVED RARE CELL DETECTION

Номер: US20170131191A1
Автор: Marfut Karen, Philip Julia, Pugia Michael
Принадлежит: SIEMENS HEALTHCARE DIGANOSTICS INC.

There is provided a system () and method () for improving ICC and/or ISH rare cell detection by lowering background noise and providing enhanced detection of rare cells (). In an embodiment, background noise for an ICC and/or an ISH rare cell detection assay is reduced and rare cell signaling is enhanced via feedback control. To accomplish the feedback control, an electronic control circuit () can direct a fluid delivery apparatus () to add an adjustment amount to account for fluid loss in the system () when fluid loss is indicated. 1. An automated system for filtration of a sample and for rare cell detection of a sample , the system comprising:a filtration apparatus comprising a membrane through which the sample is passed to provide a retentate suspected of having a quantity of rare cells;a fluid delivery apparatus that introduces a fluid onto the membrane for filtration or detection of the rare cells;at least one sensor disposed on or about the membrane to directly or indirectly indicate a level of fluid on the membrane; and a) determine when an actual amount of fluid on the membrane is less than an expected amount of fluid on the membrane based upon information from the at least one sensor;', 'b) determine an adjustment amount of fluid to add to the membrane; and', 'c) direct the fluid delivery apparatus to add the adjustment amount to the membrane., 'an electronic control circuit configured to2. The automated system of claim 1 , wherein the controller is configured to:a) upon receiving an indication from a pressure sensor of a change in the pressure from a predetermined threshold value at a point in time, determine an actual time lapsed for fluid to travel through the membrane from a starting time to the point in time;b) determine a theoretical time for fluid to travel through the membrane from the starting time to the point in time, wherein a difference between the theoretical time and the actual time is indicative of a more rapid than expected loss of the ...

Подробнее
Номер записи: 58
11-05-2017 дата публикации

Method for Determining a Particle Shape

Номер: US20170131196A1
Автор: DIETRICH Stefan, ECKARDT GUENTER, Koehler Michael, PETRAK DIETER
Принадлежит:

A method for determining a shape of particles in a distribution with reduced measuring and analyzing complexity includes detecting the number of particles, measuring and storing a particle chord length for each particle as a measurement for particle size and measuring at least first and second distributions of the particle size from the particle chord length measured for each particle. The first distribution is based on a first quantity type, the second distribution is based on a second quantity type and the quantity types correspond to different powers of the particle size. A first distribution parameter, corresponding to a cumulative or density distribution, of the first distribution is set into a distribution parameter ratio with a second distribution parameter, corresponding to a cumulative or density distribution, of the second distribution. An aspect ratio is determined from the distribution parameter ratio as a value characterizing the shape of the particles. 17-. (canceled)8. A method for determining a particle shape of particles provided in a distribution , the method comprising the following steps:detecting a number of the particles;measuring and storing a particle chord length for each particle;generating at least one first and one second distribution of a particle size from the measured particle chord length, basing the first distribution on a first quantity type, basing the second distribution on a second quantity type, and providing the quantity types used for determining the first distribution and the second distribution with different power;setting a first distribution parameter, corresponding to a cumulative or density distribution, of the first distribution into a distribution parameter ratio with a second distribution parameter, corresponding to a cumulative or density distribution, of the second distribution; anddetermining an aspect ratio from the distribution parameter ratio as a value characterizing the particle shape of the particles.9. The ...

Подробнее
Номер записи: 59
03-06-2021 дата публикации

FLOW DEVICE AND ASSOCIATED METHOD AND SYSTEM

Номер: US20210164878A1
Автор: Bork Stephan Michael, Brown Andy Walker, McBrady Adam D., Zakaria Ryadh Abdullah
Принадлежит:

A flow device, method, and system are provided for determining the fluid particle composition. An example flow device includes a fluid sensor configured to monitor at least one particle characteristic of fluid flowing through the fluid sensor. The example flow device also includes at least one processor configured to, upon determining the at least one particle characteristic satisfies a particle criteria, generate a control signal for an external device. The example flow device also includes a fluid composition sensor configured to be powered based on the control signal and further configured to capture data relating to the fluid particle composition. The example flow device is also configured to generate one or more particle profiles of at least one component of the fluid based on the data captured by the fluid composition sensor. 1. A method for controlling a flow device , the method comprising:monitoring, via a fluid sensor, signal pulses received by the fluid sensor based upon the presence of one or more particles carried by fluid flowing through the fluid sensor; andupon determining that the signal pulses satisfy one or more particle criteria, generating a control signal for an external device,wherein the one or more particle criteria defines at least one of: a threshold number of signal pulses indicative of the presence of one or more particles received by the fluid sensor or a threshold size of at least one signal pulse received by the fluid sensor.2. The method of claim 1 , wherein the monitoring of the fluid sensor is continuous.3. The method of further comprising:based on the control signal, causing a fluid composition sensor to be powered;capturing, via the fluid composition sensor, data relating to the fluid particle composition; andgenerating one or more particle profiles of at least one component of the fluid based on the data captured by the fluid composition sensor.4. The method of claim 1 , wherein the fluid sensor is an optical scanner device.5. ...

Подробнее
Номер записи: 60
18-05-2017 дата публикации

PARTICLE CHARGING DEVICE AND PARTICLE CLASSIFICATION DEVICE USING THE CHARGING DEVICE

Номер: US20170138831A1
Автор: OKUDA Hiroshi, SAKURAI Hiromu, Seki Hiroshi, Ueno Yoshihiro
Принадлежит:

In unipolar charging, a discharge current value at which charging efficiency is best and a discharge current dependency of multivalent charging differ depending on the particle size of the particles that are the object of charging. Therefore, for each particle size, a discharge voltage at which univalent charging efficiency is best and a discharge voltage at which the signal-to-noise ratio of a signal when particles of a different size are regarded as noise is best are obtained through experiment and stored in a storage unit (). When scanning a classification voltage that is applied to a classification unit () of a DMA () to measure particle size distribution, a system controlling unit () acquires an optimal voltage corresponding to a particle size from the storage unit (), and in conjunction with scanning of the classification voltage, controls a discharge power source () via a discharge voltage controlling unit () so that the discharge voltage is scanned in accordance with changes in particle size. It is thereby possible, for example, to reduce the amount of multivalent charged particles of different particle sizes that are mixed in with particles with a predetermined particle size that are extracted by classification, and to accurately determine the particle size distribution. 1. A particle charging device that , to generate charged particles to be provided for classification of particles in a gas utilizing electrical mobility , ionizes a predetermined gas by electrical discharge generated from a discharge electrode , and causes the ions and particles that are charging objects to contact to electrically charge the particles , comprising:a) a discharge voltage application unit that applies a voltage for causing electrical discharge to the discharge electrode, andb) a storage unit that stores information showing a relation between a particle size of particles that are charging objects and a voltage applied to the discharge electrode; andc) a discharge controlling ...

Подробнее
Номер записи: 61
30-04-2020 дата публикации

SYSTEMS AND METHODS FOR RAPID ELEMENTAL ANALYSIS OF AIRBORNE PARTICLES USING ATMOSPHERIC GLOW DISCHARGE OPTICAL EMISSION SPECTROSCOPY

Номер: US20200132606A1
Автор: Kulkarni Pramod P., Zheng Lina
Принадлежит: The USA, as represented by the Secretary, Department of Health and Human Services

The present disclosure relates to systems and methods for performing elemental analysis of airborne aerosols. The systems comprise an aerosol collection device for accumulating aerosol particles in a flow of aerosol particles, a radio frequency power supply for providing a glow discharge current to ablate the aerosol particles accumulated in the aerosol collection device, and an optical emission spectrometer or a mass spectrometer for analyzing elements in the ablated aerosol particles. Several types of aerosol collection devices are described. 1. A portable system for the spectroscopic analysis of aerosol particles , the system comprising: a housing defining an inlet and an outlet;', 'a corona electrode disposed proximally to the inlet; and,', 'a ground electrode disposed proximally to the outlet; wherein the ground electrode is aligned coaxially with the corona electrode and is separated from the corona electrode by a gap;, 'an aerosol collection device further comprisinga high voltage source in communication with the corona electrode;a radio frequency power supply in communication with the corona electrode;wherein the corona electrode is held at a bias voltage provided by the high voltage source;wherein a glow discharge is generated at the corona electrode by the radio frequency power supply; and, wherein the glow discharge ablates aerosol particles collected on ground electrode.2. The system of claim 1 , wherein the corona electrode has a conical distal end terminating at a tip.3. The system of claim 1 , wherein the ground electrode has a flat distal end providing a surface for aerosol particle accumulation.4. The system of claim 3 , wherein the ground electrode further comprises a sidewall sheath and the sidewall sheath having a high dielectric constant to prevent deposition of the particles on the sidewall.5. The system of wherein the inlet is in communication with an aerosol generation system.6. The system of wherein the housing is filled with a noble gas.7. ...

Подробнее
Номер записи: 62
14-08-2014 дата публикации

METHODS AND APPARATUS FOR DETERMINING PARTICLE CHARACTERISTICS

Номер: US20140226158A1
Автор: Trainer Michael
Принадлежит:

Apparatus and methods are described for determining information about at least one particle by measuring light scattered from the particles. Scattered light is detected from a region of a particle dispersion or from a larger region in a generally collimated illumination beam. Scattered light is also detected from a plurality of regions for improvement of repeatability. 1. An apparatus for determining information about at least one particle comprising:a) illuminating means for illuminating one or more particles,b) detecting means for detecting light scattered from one or more particles,c) beam splitting means for directing scattered light and light from said illuminating means to said detecting means,d) a reflector for reflecting light from the illuminating means, by means of or through said beam splitting means, to the detecting means, wherein light reflected from the reflector is combined with light scattered from one or more particles to produce an optical interference signal, wherein said reflector comprises a generally total reflector or partial reflector,e) aperture means comprising means for controlling a size of a detector in said detecting means or an aperture which is positioned between a detector, in said detecting means, and said beam splitting means, wherein said aperture means defines the size of a region in said particle dispersion, wherein a detector in said detecting means receives light scattered generally only from said region, andf) optical means for directing a portion of a scattered light and a portion of a source light from said illumination means, through said aperture means, to said detecting means.2. An apparatus for determining information about at least one particle comprising:a) illuminating means for illuminating one or more particles,b) focusing means for focusing light from said illuminating means generally at, or close to, an interface between an optical window and a dispersion of particles,c) detecting means for detecting light ...

Подробнее
Номер записи: 63
25-05-2017 дата публикации

COMBINED SORTING AND CONCENTRATING PARTICLES IN A MICROFLUIDIC DEVICE

Номер: US20170144159A1
Автор: Kapur Ravi, Smith Kyle C., Toner Mehmet
Принадлежит:

Extracting and concentrating particles from a first fluid sample includes: providing the first fluid sample to a fluid exchange module of a microfluidic device, providing a second fluid sample to the fluid exchange module, in which the first fluid sample and the second fluid sample are provided under conditions such that particle-free portions of the first fluid sample are shifted, and an inertial lift force causes the particles in the first fluid sample to cross streamlines and transfer into the second fluid sample; passing the second fluid sample containing the transferred particles to a particle concentration module under conditions such that particle-free portions of the second fluid sample are shifted, and such that the particles within the second fluid sample are focused to a streamline within the particle concentration module. 1. A microfluidic device comprising:a fluid exchange module, the fluid exchange module comprising a corresponding first microfluidic channel and a first array of island structures in the first microfluidic channel, the first array of island structures being arranged in one or more rows that extend along a longitudinal direction of the first microfluidic channel, each island structure in a row being spaced apart from an adjacent island structure in the row to form an opening,wherein the first array of island structures in the fluid exchange module is configured and arranged to shift portions of fluid through the opening between adjacent island structures within a row to a first side of the first array, leaving a remaining portion of the fluid on a second opposite side of the first array,wherein the fluid exchange module further comprises a first fluid exchange output fluidly coupled to the first side of the first array and a second fluid exchange output fluidly coupled to the second opposite side of the first array; anda particle concentration module, the particle concentration module comprising a corresponding second microfluidic ...

Подробнее
Номер записи: 64
07-05-2020 дата публикации

COMBINED SORTING AND CONCENTRATING PARTICLES IN A MICROFLUIDIC DEVICE

Номер: US20200139370A1
Автор: Kapur Ravi, Smith Kyle C., Toner Mehmet
Принадлежит:

Extracting and concentrating particles from a first fluid sample includes: providing the first fluid sample to a fluid exchange module of a microfluidic device, providing a second fluid sample to the fluid exchange module, in which the first fluid sample and the second fluid sample are provided under conditions such that particle-free portions of the first fluid sample are shifted, and an inertial lift force causes the particles in the first fluid sample to cross streamlines and transfer into the second fluid sample; passing the second fluid sample containing the transferred particles to a particle concentration module under conditions such that particle-free portions of the second fluid sample are shifted, and such that the particles within the second fluid sample are focused to a streamline within the particle concentration module. 1. A microfluidic device for extracting and concentrating particles from a fluid , the device comprising:a fluid exchange module comprising a corresponding microfluidic channel and an array of island structures in the microfluidic channel, the array of island structures being arranged in one or more rows that extend along a longitudinal direction of the microfluidic channel, each island structure in a row being spaced apart from an adjacent island structure in the row to form an opening, wherein the array of island structures in the fluid exchange module is configured and arranged to shift portions of fluid through the opening between adjacent island structures within a row to a first side of the array, leaving a remaining portion of the fluid on a second opposite side of the array; anda particle concentration module, fluidly coupled to the fluid exchange module, configured and arranged to give rise to inertial forces that focus particles contained within the fluid to concentrate the particles within a portion of the fluid.2. The microfluidic device of claim 1 , wherein a fluid input of the particle concentration module is fluidly ...

Подробнее
Номер записи: 65
07-05-2020 дата публикации

SYSTEMS AND METHODS FOR PARTICLE FOCUSING IN MICROCHANNELS

Номер: US20200139372A1
Автор: Dicarlo Dino, Edd Jon F., Irimia Daniel, Toner Mehmet
Принадлежит:

Various systems, methods, and devices are provided for focusing particles suspended within a moving fluid into one or more localized stream lines. The system can include a substrate and at least one channel provided on the substrate having an inlet and an outlet. The system can further include a fluid moving along the channel in a laminar flow having suspended particles and a pumping element driving the laminar flow of the fluid. The fluid, the channel, and the pumping element can be configured to cause inertial forces to act on the particles and to focus the particles into one or more stream lines. 1196-. (canceled)198. The method of claim 197 , wherein the tags comprise beads.199. The method of claim 197 , wherein the tags comprise antibodies.200. The method of claim 197 , wherein the tags comprise magnetic beads.201. The method of claim 197 , wherein the tags comprise quantum dots.202. The method of claim 197 , further comprising focusing the tagged particles into a particular stream line based on the changed size.203. The method of claim 197 , wherein the system further comprises a channel branch and wherein the method further comprises focusing the tagged particles into the channel branch based on the changed size.204. The method of claim 197 , wherein the one or more localized stream lines each define a width that is substantially equal to or greater than the diameter of the tagged particles claim 197 , and the tagged particles suspended in the fluid are focused into the one or more localized stream lines claim 197 , and wherein the number and relative cross-sectional position of the one or more localized stream lines are uniquely defined by the aspect ratio and the particle Reynolds number.205. The method of claim 197 , wherein the tagged particles suspended in the fluid are focused into each of at least two localized stream lines.206. The method of claim 197 , further comprising a curved channel connected to the outlet of the at least one channel claim 197 , ...

Подробнее
Номер записи: 66
31-05-2018 дата публикации

METHODS, SYSTEMS AND DEVICES FOR SELECTION AND GENERATION OF GENOME EDITED CLONES

Номер: US20180147576A1
Автор: Dyck Patricia A., Guan Radstrom Xiao, Kurz Volker L.S., Lavieu Gregory G., McEwen Jason M., MOCCIARO Annamaria, Nevill J. Tanner, Ramenani Ravi K., Soumillon Magali
Принадлежит:

Methods are described herein for isolating clonal populations of cells having a defined genetic modification. The methods are performed, at least in part, in a microfluidic device comprising one or more sequestration pens. The methods include the steps of: maintaining individual cells (or precursors thereof) that have undergone a genomic editing process in corresponding sequestration pens of a microfluidic device; expanding the individual cells into respective clonal populations of cells; and detecting, in one or more cells of each clonal population, the presence of a first nucleic acid sequence that is indicative of the presence of an on-target genome edit in the clonal population of cells. Also described are methods of performing genome editing within a microfluidic device, and compositions comprising one or more clonal populations of cells generated according to the methods disclosed herein. 1. A method of generating a clonal population of genetically modified cells in a microfluidic device comprising a sequestration pen , the method comprising:maintaining a first cell in the sequestration pen of the microfluidic device, wherein the first cell has undergone a genome editing process;expanding the first cell into a clonal population of cells; anddetecting, in one or more cells of the clonal population, the presence of a first nucleic acid sequence, wherein the first nucleic acid sequence indicates the presence of an on-target genome edit in the clonal population of cells.2. The method of claim 1 , wherein the first cell is a mammalian cell.3. (canceled).4. The method of claim 1 , wherein the first cell is an immunological cell.5. (canceled)6. The method of claim 1 , wherein the first cell is a stem cell or a progenitor cell. 7-10. (Canceled)11. The method of claim 1 , further comprising:contacting the first cell with a genome editing biomolecule; andintroducing the first cell into the microfluidic device.12. (canceled)13. The method of claim 11 , further comprising ...

Подробнее
Номер записи: 67
16-05-2019 дата публикации

Thermophoretic particle concentrator

Номер: US20190145870A1
Автор: David William Burns, David Woolsey, Justin Black
Принадлежит: Aerodyne Microsystems Inc

A system for concentrating particles in an air stream includes an air channel having a first open end and a second open end. The air channel may be enclosed by a channel wall extending from at least the first open to the second open end. Two or more heater elements may be positioned between the first open end and the second open end. The heater elements may be positioned near a periphery of the air channel and cooperatively configured to force particles in the air stream away from the periphery and towards an interior region of the air channel. Particles in the air stream may be thermophoretically forced towards the interior region of the air channel when the heater elements are heated and thermal gradients emanating from the heater elements are generated.

Подробнее
Номер записи: 68
16-05-2019 дата публикации

AIRBORNE PARTICLE DETECTION WITH SELECTIVE THERMOPHORETIC PARTICLE DEFLECTION

Номер: US20190145871A1
Автор: BURNS David William, Woolsey David
Принадлежит:

A method for analyzing particles in an air stream includes concentrating the particles in an interior region of the air stream and deflecting the concentrated particles in the air stream with a generated thermal gradient. Smaller particles in the air stream may be selectively deflected away from the interior region and towards a periphery of the air stream at a different rate than larger particles in the air stream. The generated thermal gradient may be controlled to deflect particles in a selected particle size range onto a surface of a particle detector. An effective mass of the collected particles and an aerosol mass concentration estimate of the particles within the selected particle size range may be generated. Systems for analyzing particles are also disclosed. 1. A method of analyzing particles in an air stream , the method comprising:concentrating particles in an interior region of the air stream; anddeflecting said concentrated particles in the air stream with a generated thermal gradient; wherein smaller particles in the air stream are selectively deflected away from the interior region and towards a periphery of the air stream at a different rate than larger particles in the air stream.2. The method of claim 1 , further comprising:controlling the generated thermal gradient to deflect particles in a selected particle size range onto a surface of a particle detector.3. The method of claim 1 , further comprising:controlling an airstream velocity of the air stream.4. The method of claim 1 , further comprising:collecting deflected particles within a selected particle size range on a surface of a particle detector.5. The method of claim 4 , wherein the selected particle size range includes one of a particle size range between about 0.01 microns and 0.1 microns claim 4 , 0.01 microns and 0.3 microns claim 4 , 0.1 microns and 1.0 microns claim 4 , 1.0 microns and 2.5 microns claim 4 , 2.5 microns and 10.0 microns claim 4 , and 10.0 microns and larger.6. The ...

Подробнее
Номер записи: 69
16-05-2019 дата публикации

AIRBORNE PARTICLE DETECTION SYSTEM WITH ORIENTATION-DEPENDENT PARTICLE DISCRIMINATION

Номер: US20190145872A1
Автор: BURNS David William, Woolsey David
Принадлежит:

A method for analyzing particles includes concentrating the particles in an interior region of an air stream, generating a thermal gradient to deflect the concentrated particles from the interior region of the air stream to a peripheral region of the air stream, receiving orientation information, and adjusting the thermal gradient in response to the received orientation information. The particles may be concentrated in the interior of the air stream with at least two heater elements positioned near a periphery of the air stream and configured to cooperatively force particles away from the periphery and towards the interior region of the air stream. The orientation information may include gravity vector component information or angular rate component information in one, two or three substantially orthogonal directions relative to the air stream. Various systems for airborne particle detection with orientation-dependent particle discrimination are disclosed. 1. A method of analyzing particles , the method including:concentrating particles in an interior region of an air stream;generating a thermal gradient to deflect said concentrated particles from the interior region of the air stream to a peripheral region of the air stream;receiving orientation information; andadjusting the thermal gradient in response to said received orientation information.2. The method of claim 1 , wherein the particles are concentrated in the interior region of the air stream with at least two heater elements positioned near a periphery of the air stream claim 1 , the at least two heater elements configured to cooperatively force particles away from the periphery and towards the interior region of the air stream.3. The method of claim 1 , wherein said thermal gradient deflects smaller particles at a different rate than larger particles in the air stream.4. The method of claim 1 , wherein gravity deflects heavier particles at a higher velocity in a direction of gravity more than lighter ...

Подробнее
Номер записи: 70
16-05-2019 дата публикации

Airborne particle detection system with thermophoretic scanning

Номер: US20190145873A1
Автор: David William Burns, David Woolsey
Принадлежит: Aerodyne Microsystems Inc

A system for analyzing particles in an air stream includes a first heater element configured to deflect particles in an interior region of the air stream towards a peripheral wall of an air channel encompassing the air stream, a second heater element controllable to deflect the particles in a first lateral direction along the peripheral wall, and a third heater element controllable to deflect the particles in a second lateral direction along the peripheral wall. Thermal gradients in the air channel generated by the heater elements may thermophoretically force particles towards the peripheral wall in a direction perpendicular to the air stream to allow thermophoretic forcing and scanning of particles in either the first lateral direction or the second lateral direction along the peripheral wall and onto a surface of a particle detector. Systems and methods for scanning particles with thermophoretic forces are disclosed.

Подробнее
Номер записи: 71
16-05-2019 дата публикации

THERMOPHORETIC PARTICLE DETECTION SYSTEM WITH VARIABLE CHANNEL GEOMETRY

Номер: US20190145874A1
Автор: BURNS David William, Woolsey David
Принадлежит:

A system for detecting and analyzing particles in an air stream includes an inlet, a particle concentrator and a particle discriminator having an air channel with a cross-sectional geometry that changes within at least one of the inlet, particle concentrator and particle discriminator. The system may have a sheath air stage including a port for providing sample air, at least one sheath air inlet port for providing sheath air, and a sheath air combining region. The system may include an airflow compression stage having a varying air channel that narrows as the air stream traverses the airflow compression stage to pre-concentrate particles within an interior region of the air stream. The system may include an airflow expansion stage having an air channel that widens to slow the airstream and particle velocities. A portion of the air channel height may be narrowed to allow a larger thermophoretic force to be generated. 1. A system for analyzing particles in an air stream , the system comprising:an inlet;a particle concentrator, the particle concentrator having at least two heater elements disposed on opposite sides of an air channel that encompasses the air stream, the heater elements configured to thermophoretically force particles away from a periphery of the air channel and towards an interior region of the air channel, the air channel fluidically coupled to the inlet; anda particle discriminator, the particle discriminator having at least one heater element configured to thermophoretically force particles away from the interior region of the air channel and towards a peripheral region of the air channel, the particle discriminator fluidically coupled to the particle concentrator in a direction downstream from the particle concentrator;wherein a cross-sectional geometry of said air channel changes within at least one of the inlet, the particle concentrator, and the particle discriminator.2. The system of claim 1 , wherein the inlet includes a sheath air stage claim ...

Подробнее
Номер записи: 72
17-06-2021 дата публикации

Particle sensor and method

Номер: US20210181080A1
Автор: Jan Frederik Suijver, Qiushi Zhang, Shuang Chen
Принадлежит: Koninklijke Philips NV

A particle sensor is provided for sensing the number or mass concentration of particles within a particular particle size range, the particles having a particle size distribution. The sensor comprises a light source (14) for providing light which is scattered by the particles to generate scattered light; a light detector (16, 18) for detecting the scattered light to provide a light detector signal; and a controller (24) for analyzing the light detector signal to determine information relating to the particle size distribution. Based on that information relating to the particle size distribution, the controller selects a mode of operation of the particle sensor to sense the particles only within the particular size range.

Подробнее
Номер записи: 73
23-05-2019 дата публикации

SEPARATION OF MOLECULES USING NANOPILLAR ARRAYS

Номер: US20190153516A1
Автор: Gifford Stacey M., Smith Joshua T., Wunsch Benjamin H.
Принадлежит:

A technique relates to separation of a mixture. A nano-deterministic lateral displacement (nanoDLD) array is configured to separate the mixture in a fluid. A feedback system is configured to control a velocity of the fluid through the nanoDLD array. The feedback system is configured to control the velocity of the fluid to separate one or more entities in the mixture. 1. A system for separation of a mixture , the system comprising:{'b': '0', 'a nano-deterministic lateral displacement (nanoDLD) array configured to separate the mixture in a fluid at a velocity of greater than micrometers per second to about 600 micrometers per second; and'}a feedback system configured to control the velocity of the fluid through the nanoDLD array, wherein the feedback system is configured to control the velocity of the fluid to greater than 0 micrometers per second to about 600 micrometers per second to separate one or more entities in the mixture.2. The system of claim 1 , wherein the feedback system is configured to control the velocity to cause a first type of the one or more entities laterally displaced in a first direction and to cause a second type of the one or more entities to be laterally displaced in a second direction.3. The system of claim 2 , wherein the first type and the second type of the one or more entities are different sizes.4. The system of claim 1 , wherein the feedback system includes a controller.5. The system of claim 4 , wherein the controller is configured to adjust the velocity of the fluid flowing through the nanoDLD array in order to separate the one or more entities.6. The system of claim 5 , wherein the feedback system includes a detector claim 5 , the detector configured to monitor the velocity of the fluid flowing through the nanoDLD array.7. The system of claim 6 , wherein a fluid driver is configured to inject the fluid into the nanoDLD array claim 6 , the fluid driver configured to be controlled by the controller.8. The system of claim 7 , wherein a ...

Подробнее
Номер записи: 74
08-06-2017 дата публикации

Methods for Segregating Particles Using an Apparatus with a Size-Discriminating Separation Element Having an Elongate Leading Edge

Номер: US20170160263A1
Автор: Georgi Hvichia
Принадлежит: Angle North America Inc

The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles. The breadth of the leading edge of at least one step of the apparatus is significantly greater than the overall width of the passageway in which the step occurs, permitting high and rapid sample throughput. The apparatus and methods described herein can be used to segregate particles of a wide variety of types. By way of example, they can be used to segregate circulating tumor cells from a human blood sample.

Подробнее
Номер записи: 75
24-06-2021 дата публикации

Slurry Monitor Coupling Bulk Size Distribution and Single Particle Detection

Номер: US20210190659A1
Автор: KNOLLENBERG Brian A., RODIER Daniel
Принадлежит: PARTICLE MEASURING SYSTEMS, INC.

Provided herein are particle detection systems, and related methods configured to characterize a liquid sample, comprising: a first probe configured to determine a first parameter set of a plurality of first particles in a liquid sample, the first particles characterized by a size characteristic selected from a first size range; wherein the first parameter set comprises a first size distribution and a first concentration; and a second probe configured to determine a second parameter set of one or more second particles in the liquid sample, the second particles being characterized by a size characteristic selected from a second size range; wherein the second parameter set comprises a second size distribution and a second concentration. 1. A particle detection system configured to characterize a liquid sample , said particle detection system comprising: 'wherein said first parameter set comprises a first size distribution and a first concentration; and', 'a first probe configured to determine a first parameter set of a plurality of first small particles in said liquid sample, said first particles being characterized by a size characteristic selected from a first size range;'} 'wherein said second parameter set comprises a second size distribution and a second concentration;', 'a second probe configured to determine a second parameter set of one or more second large particles in said liquid sample, said second particles being characterized by a size characteristic selected from a second size range;'}wherein said first size distribution has an average first size and said second size distribution has an average second size, and said average first size is less than said average second size, and said first concentration is greater than said second concentration.2. The system of claim 1 , wherein the first size range and the second size range overlap.3. The system of claim 1 , wherein the first size range does not overlap with the second size range.4. The system of claim 1 ...

Подробнее
Номер записи: 76
24-06-2021 дата публикации

DEVICE FOR DETECTING PARTICLES IN AIR

Номер: US20210190660A1
Автор: LAMBRECHTS Andy, LIN Ziduo, STAHL Richard, VANMEERBEECK Geert, YURT Abdulkadir
Принадлежит:

A device for detecting particles in air; said device comprising: 1. A device for detecting particles in air; said device comprising:a flow channel comprising an inlet and an outlet, wherein the flow channel is configured to allow a flow of air comprising particles through the flow channel from the inlet to the outlet;a light source configured to illuminate the particles in the flow of air, such that an interference pattern is formed by interference between light being scattered by the particles and non-scattered light from the light source;an image sensor comprising a plurality of photo-sensitive elements configured to detect incident light, the image sensor being configured to detect the interference pattern, and wherein the image sensor is configured to acquire a time-sequence of image frames, each image frame comprising a plurality of pixels, each pixel representing an intensity of light as detected by a photo-sensitive element of the plurality of photo-sensitive elements; and identifying pixels of interest in the time-sequence of image frames, said pixels of interest picturing an interference pattern potentially representing a particle in the flow of air, and', 'outputting said identified pixels of interest for performing digital holographic reconstruction on the identified pixels of interest., 'a frame processor configured to filter information in the time-sequence of image frames, wherein said filtering comprises2. The device according to claim 1 , wherein the light source is configured to emit at least partially coherent light.3. The device according to claim 1 , wherein:the light source is arranged outside a first side wall of the flow channel;the image sensor is arranged outside a second side wall of the flow channel; andthe flow channel is configured to provide a light path from the light source to the image sensor through the first side wall of the flow channel, through the flow of air in the flow channel and through the second side wall.4. The device ...

Подробнее
Номер записи: 77
24-06-2021 дата публикации

Device for detecting particles in air

Номер: US20210190663A1
Автор: Abdulkadir YURT, Geert Vanmeerbeeck, Richard Stahl, Ziduo Lin
Принадлежит: Interuniversitair Microelektronica Centrum vzw IMEC

The inventive concept relates to a device for detecting particles in air, said device comprising a receiver for receiving a flow of air comprising particles, a sample carrier, and a particle capturing arrangement. The particle capturing arrangement is configured to separate the particles from the flow of air for and to collect a set of particles on a surface of the sample carrier. The device further comprises a light source configured to illuminate the particles on the sample carrier, such that an interference pattern is formed by interference between light being scattered by the particles and non-scattered light from the light source. The device further comprises an image sensor configured to detect the interference pattern. The device further comprises a cleaner configured for cleaning the surface of the sample carrier for enabling re-use of the surface for collection of a subsequent set of particles.

Подробнее
Номер записи: 78
24-06-2021 дата публикации

Collector for collecting particles in air and a device for detecting particles in air

Номер: US20210190670A1
Автор: Abdulkadir YURT, Andy Lambrechts, Geert Vanmeerbeeck, Richard Stahl, Ziduo Lin
Принадлежит: Interuniversitair Microelektronica Centrum vzw IMEC

The inventive concept relates to a collector for collecting particles in air and a device for detecting particles in air comprising said collector. Said collector comprises a substrate, which is adapted to enable imaging of the particles, an adhesive layer arranged on a collector side of the substrate, said adhesive layer being formed by an adhesive material. The collector further comprises a protection element, which is configured to protect the adhesive layer before collection of particles. The collector is configured to allow release of protection of the adhesive layer by the protection element to expose an adhesive surface of the adhesive layer to ambient air for collecting particles on the adhesive surface. The collector is further configured for presenting a particle sample carrier having a smooth top surface and a smooth bottom surface for preventing light from being diffusely scattered by the particle sample carrier.

Подробнее
Номер записи: 79
24-06-2021 дата публикации

IMAGE PICKUP APPARATUS

Номер: US20210191096A1
Автор: ODAIRA Mayumi, WATANABE Satoshi
Принадлежит: OLYMPUS CORPORATION

An image pickup apparatus includes a signal acquisition unit and a rotation unit. The signal acquisition unit includes an illumination unit including a light source and configured to irradiate a sample with a light beam, a photodetector including a plurality of light-receiving portions two-dimensionally arranged, and a detection optical system configured to guide light having been irradiated from the illumination unit to the sample and passed through the sample, to the photodetector. The rotation unit rotates the sample and the signal acquisition unit relative to each other, about a first axis intersecting an optical axis of the detection optical system in the sample. The illumination unit irradiates the sample with light beams at two or more incident angles in a plane including the optical axis and the first axis. 1. An image pickup apparatus comprisinga signal acquisition unit and a rotation unit, whereinthe signal acquisition unit includes an illumination unit including a light source and configured to irradiate a sample with a parallel light beam, a photodetector including a plurality of light-receiving portions two-dimensionally arranged, and a detection optical system configured to guide light having been irradiated from the illumination unit to the sample and passed through the sample, to the photodetector,the rotation unit rotates the sample and the signal acquisition unit relative to each other, about a first axis intersecting an optical axis of the detection optical system in the sample,the illumination unit irradiates the sample with parallel light beams at two or more incident angles, for each of different rotation states between the sample and the signal acquisition unit, in a plane including the optical axis and the first axis,the illumination unit does not simultaneously irradiate the respective parallel light beams at two or more different incident angles which irradiate the sample, andthe photodetector detects light corresponding to each of the ...

Подробнее
Номер записи: 80
14-06-2018 дата публикации

Sorting particles in a microfluidic device

Номер: US20180161775A1
Автор: Kyle C. Smith, Mehmet Toner, Ravi Kapur
Принадлежит: General Hospital Corp

A microfluidic device includes a particle sorting region having a first, second and third microfluidic channels, a first array of islands separating the first microfluidic channel from the second microfluidic channel, and a second array of islands separating the first microfluidic channel from the third microfluidic channel, in which the island arrays and the microfluidic channels are arranged so that a first fluid is extracted from the first microfluidic channel into the second microfluidic channel and a second fluid is extracted from the third microfluidic channel into the first microfluidic channel, and so that particles are transferred from the first fluid sample into the second fluid sample within the first microfluidic channel.

Подробнее
Номер записи: 81
21-05-2020 дата публикации

Slurry Monitor Coupling Bulk Size Distribution and Single Particle Detection

Номер: US20200158616A1
Автор: KNOLLENBERG Brian A., RODIER Daniel
Принадлежит:

Provided herein are particle detection systems, and related methods configured to characterize a liquid sample, comprising: a first probe configured to determine a first parameter set of a plurality of first particles in a liquid sample, the first particles characterized by a size characteristic selected from a first size range; wherein the first parameter set comprises a first size distribution and a first concentration; and a second probe configured to determine a second parameter set of one or more second particles in the liquid sample, the second particles being characterized by a size characteristic selected from a second size range; wherein the second parameter set comprises a second size distribution and a second concentration. 1. A particle detection system configured to characterize a liquid sample , said particle detection system comprising: 'wherein said first parameter set comprises a first size distribution and a first concentration; and', 'a first probe configured to determine a first parameter set of a plurality of first particles in said liquid sample, said first particles being characterized by a size characteristic selected from a first size range;'} 'wherein said second parameter set comprises a second size distribution and a second concentration.', 'a second probe configured to determine a second parameter set of one or more second particles in said liquid sample, said second particles being characterized by a size characteristic selected from a second size range;'}2. The system of claim 1 , wherein the first size range and the second size range overlap.3. (canceled)4. The system of claim 1 , wherein the first size range is characterized by a size that is less than or equal to 200 nm and the second size-size is characterized by a size that is greater than 200 nm.5. (canceled)6. (canceled)7. (canceled)8. The system of further comprising a third probe claim 1 , said third probe configured to determine a third parameter set of a plurality of third ...

Подробнее
Номер записи: 82
01-07-2021 дата публикации

Method for Determining a Three-Dimensional Particle Distribution in a Medium

Номер: US20210199552A1
Автор: Erik Olof Reimhult, Petrus Dominicus Joannes van OOSTRUM
Принадлежит: Universitaet fuer Bodenkultur Wien BOKU

The disclosed subject matter relates to a method for determining a three-dimensional particle distribution in a medium, comprising: emitting a coherent light beam to irradiate the sample; recording an interference image of the scattered light beam and a second part of the light beam that has not been scattered; computing, from the interference image, for each one of a plurality of virtual planes lying within the sample, a reconstructed image of the sample, generating for each reconstructed image, a presence image, wherein a value is assigned to each pixel of the presence images if the corresponding pixel of the reconstructed image has an intensity value exceeding a threshold value and if the corresponding pixel of the reconstructed image has a phase value with a predetermined sign.

Подробнее
Номер записи: 83
06-06-2019 дата публикации

CASCADE IMPACTOR PLATE COATING

Номер: US20190170629A1
Автор: SILCOCK Alan James
Принадлежит: KIND CONSUMER LIMITED

The present invention relates to a cascade impactor for measuring particle size distribution of an aerosol comprising nicotine, the cascade impactor comprising: an induction port for receiving an inhaler; and at least one sample collection stage comprising a nozzle assembly and a collection means; wherein the collection means of at least one sample collection stage is coated with isopropyl alcohol. 1. A cascade impactor for measuring particle size distribution of an aerosol comprising nicotine , the cascade impactor comprising:an induction port for receiving an inhaler; andat least one sample collection stage comprising a nozzle assembly and a collection means;wherein the collection means of at least one sample collection stage is coated with isopropyl alcohol.2. A cascade impactor according to claim 1 , wherein the cascade impactor comprises at least five collection stages.3. A cascade impactor according to claim 1 , wherein the cascade impactor comprises seven collection stages.4. A cascade impactor according to claim 1 , wherein the cascade impactor is a Next Generation Impactor claim 1 , an Andersen Cascade Impactor claim 1 , a Multi-stage Liquid Impinger claim 1 , a Marple-Miller Cascade Impactor or a Twin Impinger.5. A cascade impactor according to claim 1 , wherein the cascade impactor is a Next Generation Impactor.6. A cascade impactor according to claim 1 , wherein the cascade impactor is a Next Generation Impactor comprising seven sample collection stages.7. A cascade impactor according to claim 6 , wherein the cascade impactor further comprises a micro-orifice collector.8. A cascade impactor according to claim 1 , wherein the isopropyl alcohol is present in an amount of no greater than 5 mL in each of the sample collection stages that are coated with isopropyl alcohol.9. A cascade impactor according to claim 1 , wherein the isopropyl alcohol is present in an amount of no greater than 3 mL in each of the sample collection stages that are coated with ...

Подробнее
Номер записи: 84
28-05-2020 дата публикации

Particle characterisation with a focus tuneable lens

Номер: US20200166446A1
Автор: David Bryce, Jason Cecil William Corbett
Принадлежит: Malvern Panalytical Ltd

A particle characterisation apparatus comprising: a light source for illuminating a sample with a light beam; a detector arranged to detect scattered light from the interaction of the light beam with the sample; a focus tuneable lens arranged to collect the scattered light for the detector from a scattering volume and/or to direct the light beam into the sample, a sample holder with an opposed pair of electrodes and configured to hold a sample in position in a measurement volume between the pair of electrodes such that a planar surface of the sample is aligned orthogonally to the electrode surfaces, the planar surface adjacent to the scattering volume, wherein adjustment of the focus tuneable lens results in adjustment of the relative position of the planar surface and the scattering volume by moving the scattering volume.

Подробнее
Номер записи: 85
18-09-2014 дата публикации

Method and device for determining the size of a transparent particle

Номер: US20140268142A1
Автор: Cameron Tropea, Walter Schaefer
Принадлежит: TECHNISCHE UNIVERSITAET DARMSTADT

A method is described for determining the size of a transparent particle ( 2 ), wherein the particle ( 2 ) is illuminated with light from a light source ( 6 ), wherein using a radiation detector ( 7 ) a time-resolved intensity curve of light from the light source ( 6 ) scattered on the particle ( 2 ) is measured at a preselectable scattering angle θ s , wherein characteristic scattered light peaks are determined in the intensity curve, and wherein the size of the particle ( 2 ) is determined on the basis of the time difference between two scattered light peaks, characterized in that, with the help of two radiation detectors ( 7 ) or light sources ( 6 ), a first and a second time-resolved intensity curve of scattered light, scattered on the particle ( 2 ) in the forward direction, are measured; a transmission peak ( 12 ) and a reflection peak ( 11 ) are determined from the first intensity curve and from the second intensity curve; a first time difference between the transmission peaks ( 12 ) is determined, and a second time difference between the reflection peaks ( 11 ) is determined; a characteristic variable α is determined from the ratio of the first time difference and the second time difference; and a size determination is performed for the particles ( 2 ) for which the characteristic variable α corresponds to a preselectable value.

Подробнее
Номер записи: 86
18-09-2014 дата публикации

METHOD AND DEVICE FOR DETERMINING CHARACTERISTIC PROPERTIES OF A TRANSPARENT PARTICLE

Номер: US20140268143A1
Автор: SCHAEFER Walter, TROPEA Cameron
Принадлежит: TECHNISCHE UNIVERSITAET DARMSTADT

The invention relates to a method for determining the size d of a transparent particle, according to which method the particle is illuminated with light from a light source, a radiation detector measures a time-resolved intensity profile of light of the light source scattered by the particle, a reflection peak () and a refraction peak are determined in the intensity profile and the size d of the particle is determined based on a time difference between the reflection peak () and the refraction peak. The method according to the invention is characterized in that the time-resolved intensity profile is measured at a definable scattering angle θs, a first second-order refraction peak () and a second second-order refraction peak () having a mode different from that of the first refraction peak () being determined, a characteristic variable γ being determined as the ratio of a first time difference Δtbetween the reflection peak () and the first refraction peak () and of a second time difference Δtbetween the reflection peak () and the second refraction peak (), and the size of only those particles being determined for which the characteristic variable γ corresponds to a definable value. 1. A method for determining characteristic properties of a transparent particle , wherein the particle is illuminated with light from a light source , wherein a time-resolved intensity profile of light from the light source that is scattered at the particle is measured by a radiation detector at a predefinable scattering angle θ , wherein characteristic scattered light peaks are determined in the intensity profile , and wherein a size of the particle is determined based on a time difference between two scattered light peaks ,wherein a first time difference is determined between a first pair of scattered light peaks and a second time difference is determined between a second pair of scattered light peaks, a characteristic variable is determined from the ratio of the first time difference ...

Подробнее
Номер записи: 87
08-07-2021 дата публикации

Particle characterisation

Номер: US20210208047A1
Автор: Alex MALM, Jason Corbett
Принадлежит: Malvern Panalytical Ltd

Disclosed herein is a method of characterizing particles in a sample. The method comprises illuminating the sample in a sample cell with a light beam, so as to produce scattered light by the interaction of the light beam with the sample; obtaining a time series of measurements of the scattered light from a single detector; determining, from the time series of measurements from the single detector, which measurements were taken at times when a large particle was contributing to the scattered light; determining a particle size distribution, including correcting for light scattered by the large particle.

Подробнее
Номер записи: 88
08-07-2021 дата публикации

PARTICLE SIZE DISTRIBUTION MEASURING DEVICE AND PROGRAM FOR PARTICLE SIZE DISTRIBUTION MEASURING DEVICE

Номер: US20210208048A1
Автор: AKIYAMA Hisashi, Mori Tetsuya, NAGAOKA Eiichi
Принадлежит:

To enable the particle size distribution of a measurement target to be accurately measured regardless of the presence of a particle which is similar in shape to the measurement target and which is not the measurement target, a particle size distribution measuring device includes an image processing unit that receives image data obtained by capturing an image of a particle group including a first particle and a second particle of a type different from the first particle, at least the first particle being translucent; and a particle discriminating unit that discriminates whether a particle depicted in the image is the first particle or the second particle on the basis of light and dark regions that appear as a result of refraction of light passing through the particle. 1. A particle size distribution measuring device comprising:an image processing unit that receives image data obtained by capturing an image of a particle group including a first particle and a second particle of a type different from the first particle, at least the first particle being translucent; anda particle discriminating unit that discriminates whether a particle depicted in the image is the first particle or the second particle on the basis of light and dark regions that appear as a result of refraction of light passing through the particle.2. The particle size distribution measuring device according to claim 1 , whereinthe second particle is translucent, andthe particle discriminating unit discriminates whether the particle depicted in the image is the first particle or the second particle on the basis of an image difference in the light and dark regions, the image difference arising from a difference between a refractive index of the first particle and a refractive index of the second particle.3. The particle size distribution measuring device according to claim 2 , wherein the first particle is a measurement target and the second particle is a bubble.4. The particle size distribution ...

Подробнее
Номер записи: 89
18-09-2014 дата публикации

Methods for Segregating Particles Using an Apparatus with a Size-Discriminating Separation Element Having an Elongate Leading Edge

Номер: US20140271909A1
Автор: George Hvichia
Принадлежит: Parsortix Inc

The disclosure relates to an apparatus for segregating particles on the basis of their ability to flow through a stepped passageway. At least some of the particles are unable to pass through a narrower passageway bounded by a segregating step, resulting in segregation of the particles. The breadth of the leading edge of at least one step of the apparatus is significantly greater than the overall width of the passageway in which the step occurs, permitting high and rapid sample throughput. The apparatus and methods described herein can be used to segregate particles of a wide variety of types. By way of example, they can be used to segregate circulating tumor cells from a human blood sample.

Подробнее
Номер записи: 90
09-07-2015 дата публикации

Method of identifying components in a fluid mixture

Номер: US20150192572A1
Автор: Amy Anderson, Daniel Mueth, Jessica Shireman, Joseph Plewa, Lewis Gruber, Neil Rosenbaum
Принадлежит: Premium Genetics UK Ltd

A method of identifying at least one component from a plurality of components in a fluid mixture introduced into a flow apparatus, includes: introducing a first flow into a first input channel in the apparatus which contains the fluid mixture; introducing additional flows of buffer solution into a plurality of buffer input channels in the apparatus, the plurality of buffer channels which are disposed on either side of the first input channel; wherein the first flow and additional flows have a flow direction along a length of the apparatus; identifying selected components of the plurality of components using a detector apparatus; emitting a light beam from a laser which damages or kills selected components of the plurality of components; receiving the first flow and the additional flows in at least one channel disposed at the other end of the apparatus, after operation of the light beam on the selected components.

Подробнее
Номер записи: 91
04-06-2020 дата публикации

SENSOR FOR MEASURING THE CONCENTRATION OF PARTICLES IN AIR

Номер: US20200173901A1
Автор: DUMAS Antoine, GLAVATSKAYA Yulia, GOUVERNEUR Guillaume, Martinell Amanda
Принадлежит:

A sensor includes an inner channel with: a first portion; a second portion in communication with the first portion; a storage zone in communication with the first portion; a baffle plate extending inside the first portion; the first portion and the baffle plate being sized such that, in an air stream entering the sensor through a first, open end of the first portion and containing first particles with a diameter of 10 μm or less and second particles with a diameter of more than 10 μm, the first particles reach the second portion of the inner channel while the second particles reach the storage zone. 2. The sensor according to claim 1 , wherein the second portion of the inner channel has a first open end communicating with the first portion of the inner channel and a second open end claim 1 , wherein the sensor comprises a device for circulating an air stream in the inner channel claim 1 , said device being arranged at the second end of the second portion of the inner channel and being configured to make an air stream circulate from the first end of the first portion of the inner channel to the second end of the second portion of the inner channel.3. The sensor according to claim 2 , wherein the device for circulating an air stream in the inner channel is a fan or a pump.5. The sensor according to wherein the second portion of the inner channel has a first open end communicating with the first portion of the inner channel and a second open end claim 1 , and the second portion of the inner channel comprises a detection zone claim 1 , an upstream zone between the first end and the detection zone and a downstream zone between the detection zone and the second end claim 1 , wherein:the second portion of the inner channel has a folded back shape, and the inclined portion forming an angle β, measured with respect to the vertical, such that: 60°≤β≤80°, and', {'sup': 2', '2, 'the inclined portion widening by 150 μmto 300 μmper mm of length.'}], 'the upstream zone of the ...

Подробнее
Номер записи: 92
05-07-2018 дата публикации

Method and Device for Classifying Superabsorbent Particles

Номер: US20180188149A1
Автор: Funk Rüdiger, Stephan Oskar, Voll Norbert Eugen
Принадлежит:

A method for the classification of superabsorber particles is disclosed, in which the superabsorber particles are put onto a top screen deck of a screening machine having at least two screen decks with a different hole size, the superabsorber particles which are smaller than the holes of the respective screen deck respectively falling through the holes and the superabsorber particles remaining on the screen deck being removed via an extraction point. Balls are positioned on each perforated plate, which balls are propelled upward by the movement of the perforated plate and strike from below the screen deck respectively lying above, wherein the balls have a stiffness in the range from 40 to 100 N/mm and a damping in the range from 1 to 4%. A machine for carrying out the method also is disclosed. 177771714717. A method for the classification of superabsorber particles , in which the superabsorber particles are put onto a top screen deck () of a screening machine comprising at least two screen decks () with a different hole size , the superabsorber particles which are smaller than the holes of the respective screen deck () respectively falling through the holes and the superabsorber particles remaining on the screen deck () being removed via an extraction point () , wherein balls () are positioned below each screen deck () , which balls are propelled upward by the movement of the screening machine () and strike from below the screen deck () respectively lying above , wherein the balls have a stiffness in the range from 40 to 100 N/mm and a damping in the range from 1 to 4%.21314. The method according to claim 1 , wherein a perforated plate () is positioned below each screen deck claim 1 , and the balls () rest on the perforated plate.314. The method according to claim 1 , wherein the balls () have a diameter in the range of from 20 to 60 mm.414. The method according to claim 1 , wherein the balls () have a rebound elasticity in the range of from 60 to 85%.514. The ...

Подробнее
Номер записи: 93
11-06-2020 дата публикации

Aerosol Sensor for Performing Counting and Multiwavelength or Multiangle Measurement in Combination

Номер: US20200182765A1
Автор: Biswas Pratim, Chadha Tandeep S., Fang Jiaxi
Принадлежит: Applied Particle Technology, Inc.

A method and apparatus for particle counting and wavelength or angle performed in combination in order to characterize an aerosol is disclosed. In one example, data regarding particle counting (such as from an optical particle sensor) and data regarding angle or wavelength (such as from an ensemble measurement sensor) may be separately generated, with the separately generated data being analyzed in combination in order to characterize the aerosol. In another example, data regarding particle counting and regarding angle or wavelength may be generated in combination in order to characterize the aerosol. 1. A fluid optical characterization system comprising:a single particle sensor comprising a first chamber and configured to generate single particle data indicative of detecting single particles for a fluid in the first chamber;an ensemble measurement sensor comprising a second chamber and configured to generate ensemble measurement data indicative of detecting at least one of scattering wavelength or scattering angle of multiple particles for the fluid in the second chamber; and access the single particle data and the ensemble measurement data; and', 'analyze, in combination, single particle analysis data and ensemble measurement analysis data in order to determine at least one property of the fluid, wherein the single particle analysis data comprises the single particle data or is derived from the single particle data, and wherein the ensemble measurement analysis data comprises the ensemble measurement data or is derived from the ensemble measurement data., 'processing functionality configured to2. The fluid optical characterization system of claim 1 , wherein the single particle sensor comprises an optical particle counter (OPC) sensor; andwherein the ensemble measurement sensor comprises one of a multiwavelength ensemble particle sensor or a multi-angle ensemble particle sensor.3. The fluid optical characterization system of claim 2 , wherein the fluid comprises ...

Подробнее
Номер записи: 94
20-06-2019 дата публикации

DETECTING MICROSCOPIC OBJECTS IN FLUIDS

Номер: US20190187613A1
Автор: Hämäläinen Esa, KESTI Tero
Принадлежит: UWATER Oy

A method having the steps of obtaining prepared image data captured by an image sensor receiving light propagated across a sample volume, containing a fluid possibly comprising microscopic objects of foreign origin, while illuminating the sample volume by coherent light. The prepared image data comprising, for a microscopic object, a prepared hologram pattern with prepared spatially alternating intensity formed by the interference fringes; providing filtered image data, comprising automatically filtering the prepared image data by an edge enhancing filter. the filtered image data comprising, for a prepared hologram pattern, a filtered hologram pattern. The presence of the microscopic object associated with the filtered hologram pattern in the sample volume of the fluid is automatically detected on the basis of the filtered hologram pattern. 1. A method for detecting microscopic objects of foreign origin present in a fluid , the method comprising:obtaining prepared image data originating from a hologram digital image frame captured by an image sensor receiving light propagated across a sample volume, containing a fluid possibly comprising microscopic objects of foreign origin, while illuminating the sample volume by coherent light, whereby the possible microscopic objects scatter part of the light, the scattered and non-scattered light interfering so as to form interference fringes behind the microscopic objects, the prepared image data comprising, for a microscopic object, a prepared hologram pattern with prepared spatially alternating intensity formed by the interference fringes;providing filtered image data, comprising automatically filtering the prepared image data by an edge enhancing filter, the filtered image data comprising, for a prepared hologram pattern present in the prepared image data, a filtered hologram pattern; andautomatically detecting, on the basis of the filtered hologram pattern, the presence of the microscopic object associated with the ...

Подробнее
Номер записи: 95
22-07-2021 дата публикации

FLUID COMPOSITION SENSOR DEVICE AND METHOD OF USING THE SAME

Номер: US20210223155A1
Автор: Brown Andy Walker, Myers Ronald W., Sorenson Richard Charles, Speldrich Jamie W.
Принадлежит:

Various embodiments described herein relate to apparatuses and methods for detecting fluid particles and their characteristics. In various embodiments, a device for detecting fluid particles and their characteristics may comprise a lens free holographic microscope configured to collect fluid particles via inertial impaction. In various embodiments, the collection media may be replaceable within the apparatus. In various embodiments, the impactor nozzle may be selectively configured to avoid optical reflections and scattering from illumination light passing through the nozzle. Various embodiments are directed to a collection media assembly for receiving particles from a volume of fluid within a fluid composition sensor. A collection media assembly may comprise a collection media, an orifice, a seal engagement portion and a frame element configured to facilitate the serial use of a plurality of collection media assemblies within a fluid composition sensor. 1. A device for detecting fluid particle characteristics comprising: a housing defining an internal sensor portion and comprising a fluid inlet configured to receive the volume of fluid;', 'an impactor nozzle disposed within the internal sensor portion and configured to receive at least a portion of the volume of fluid such that the at least a portion of the volume of fluid received by the impactor is directed in a fluid flow direction;', 'at least one collection media configured to receive one or more particles of a plurality of particles within the volume of fluid, at least a portion of the at least one collection media being disposed within the internal sensor portion, wherein each of the at least one collection media comprises at least one orifice configured to allow at least a portion of the volume of fluid to flow therethrough; and', 'an imaging device configured to capture an image of at least a portion of the one or more particles of the plurality of particles received by the at least one collection media; ...

Подробнее
Номер записи: 96
19-07-2018 дата публикации

Devices for Separating Constituents in a Sample and Methods for Use Thereof

Номер: US20180200717A1
Автор: Sohn Lydia Lee, Yang Daniel K.
Принадлежит:

Devices for separating constituents (e.g., cells) in a fluid sample are provided. The device includes a microfluidic conduit configured to carry a flow of a fluid sample and includes two or more separation elements, each separation element including a first region and a second region, where the first region has a cross-sectional area less than a cross-sectional area of the second region. The device also includes a flow resistive element in fluid communication with the microfluidic conduit in a region between two adjacent separation elements. Also provided are methods of using the devices, as well as systems and kits that include the devices. The devices, systems, methods and kits find use in a variety of different applications, including diagnostic assays. 1. A device for separating constituents in a fluid sample , the device comprising:a microfluidic conduit configured to carry a flow of a fluid sample and comprising two or more separation elements, each separation element comprising a first region and a second region, wherein the first region has a cross-sectional area less than a cross-sectional area of the second region; anda flow resistive element in fluid communication with the microfluidic conduit in a region between two adjacent separation elements.2. The device of claim 1 , wherein the first region and the second region of each separation element are arranged symmetrically about a longitudinal axis of the microfluidic conduit.3. The device of claim 1 , wherein the first region and the second region of each separation element are arranged asymmetrically about a longitudinal axis of the microfluidic conduit.4. The device of claim 1 , wherein the two or more separation elements are arranged in series.5. The device of claim 1 , wherein the two or more separation elements are arranged in parallel.6. The device of claim 1 , wherein the two or more separation elements are arranged in series and in parallel.7. The device of claim 1 , wherein the device comprises:a ...

Подробнее
Номер записи: 97
05-08-2021 дата публикации

Biological Fluid Filtration System

Номер: US20210237065A1
Автор: Jayant Parthasarathy
Принадлежит: Astrin Biosciences Inc

A biological fluid filtration system for scanning a biological fluid so as to filter potentially undesirable constituents from the biological fluid for therapeutic or diagnostic purposes. The biological fluid filtration system generally includes a fluid receiving device adapted to receive a biological fluid. A valve including an inlet, a first outlet, and a second outlet is fluidly connected to the fluid receiving device. The biological fluid within the fluid receiving device is scanned by a scanner to produce scanned data relating to the biological fluid. A control unit in communication with the scanner and the valve receives the scanned data and controls the valve based on the scanned data. The valve is controlled to direct the biological fluid through either the first or second outlet of the valve depending upon the constituents of the biological fluid identified by the control unit.

Подробнее
Номер записи: 98
05-08-2021 дата публикации

Biological Fluid Filtration System

Номер: US20210237068A1
Автор: Jayant Parthasarathy
Принадлежит: Astrin Biosciences Inc

A biological fluid filtration system for scanning a biological fluid so as to filter potentially undesirable constituents from the biological fluid for therapeutic or diagnostic purposes. The biological fluid filtration system generally includes a fluid receiving device adapted to receive a biological fluid. A valve including an inlet, a first outlet, and a second outlet is fluidly connected to the fluid receiving device. The biological fluid within the fluid receiving device is scanned by a scanner to produce scanned data relating to the biological fluid. A control unit in communication with the scanner and the valve receives the scanned data and controls the valve based on the scanned data. The valve is controlled to direct the biological fluid through either the first or second outlet of the valve depending upon the constituents of the biological fluid identified by the control unit.

Подробнее
Номер записи: 99
05-08-2021 дата публикации

Biological Fluid Filtration System

Номер: US20210237069A1
Автор: Jayant Parthasarathy
Принадлежит: Astrin Biosciences Inc

A biological fluid filtration system for scanning a biological fluid so as to filter potentially undesirable constituents from the biological fluid for therapeutic or diagnostic purposes. The biological fluid filtration system generally includes a fluid receiving device adapted to receive a biological fluid. A valve including an inlet, a first outlet, and a second outlet is fluidly connected to the fluid receiving device. The biological fluid within the fluid receiving device is scanned by a scanner to produce scanned data relating to the biological fluid. A control unit in communication with the scanner and the valve receives the scanned data and controls the valve based on the scanned data. The valve is controlled to direct the biological fluid through either the first or second outlet of the valve depending upon the constituents of the biological fluid identified by the control unit.

Подробнее
Номер записи: 100