Verfahren zum Herstellen einer Membrankappe

Die Erfindung betrifft einen Verfahren zum Herstellen einer Membrankappe (1) für einen Sensor zur Bestimmung und/oder Überwachung der Konzentration eines Analyten in einem Messmedium, umfassend den Verfahrensschritt, Erzeugen der Membrankappe (1) mittels eines Fertigungsverfahrens, so dass die Membrankappe (1) einen hohlförmigen Kappenkörper (2) aufweist, und dass die Membrankappe (1) an einer mit einem Messmedium zu kontaktierenden Stirnfläche (3) eine für das Messmedium und/oder für zumindest einen in dem Messmedium enthaltenen Analyten durchlässige Membran (4) aufweist, und dass die Membran (4) und der Kappenkörper (2) einstückig ausgestaltet sind.

Elektrochemischer Sensor

Die Erfindung betrifft einen elektrochemischen Sensor (1, 30) zur Bestimmung einer mit einer Konzentration eines Analyten in einem Messfluid korrelierenden Messgröße, umfassend:- eine Sensormembran (14, 37, 51), die dazu ausgestaltet ist, in Kontakt mit dem Messfluid zur Erfassung von Messwerten der Messgröße zu dienen;- ein Sondengehäuse (33, 52), das mindestens einen zum Eintauchen in das Messfluid gestalteten Eintauchbereich aufweist, wobei die Sensormembran (14, 37, 51) in dem Eintauchbereich des Sondengehäuses (33, 52) angeordnet ist; und- eine mindestens teilweise in dem Sondengehäuse (33, 52) enthaltene Messschaltung (25, 41), die dazu ausgestaltet ist, ein von der Messgröße abhängiges Messsignal zu erzeugen und auszugeben, wobei die Sensormembran (14, 37, 51) eine optisch detektierbare Substanz (27) zur Kennzeichnung der Sensormembran (14, 37, 51) enthält.

SENSOR SYSTEM

PC 7147 A sensor system for determining the pH or carbon dioxide concentration of a liquid medium comprising, in combination, a pH-insensitive fluorescent indicator and a pH-sensitive fluorescent indicator which act in concert or a single fluorescence indicator which emits fluorescent signals of different wavelengths in different carriers, which system(s) produce diverging signals, the ratio of which provides an accurate and stable determination of the parameter being measured. A method for determing pH and CO2 concentration is also disclosed.

OPTICAL METHOD AND SYSTEM FOR MEASURING AN ENVIRONMENTAL PARAMETER

An optical system for sensing an environmental parameter, comprising: a pulse generator for generating a first pulse having a first wavelength and a second pulse having a second wavelength; a pulse splitter for splitting each one of the first and second pulse into a sensing pulse and a reference pulse; a sensing arm for receiving the sensing pulses therefrom and comprising a spectro-ratiometric sensor; a reference arm for receiving the reference pulses; a time delay line for delaying a relative propagation of the sensing pulses and the reference pulses; a light detector for measuring an optical energy of the sensing pulse and the reference pulse, for the first and second wavelengths; and at least one optical link for optically connecting the pulse generator to the pulse splitter, and the sensing and reference arms to the light detector.

Device for measuring concentrations of particles of matter

The device has a tracer space (11) consisting of a tracer substance and a membrane enclosing the tracer substance, for measuring concentrations of matter particles by means of an optical light measuring device containing a light source, a light receiver and an indicating instrument. The tracer space (11) is preceded by a reaction space (13), containing at least one reagent and closed off by a membrane (14), for the matter particles to be measured in order to have a reaction space independent of the tracer space. ...

Method for displaying the sound fruit or vegetable carbon dioxide content climacteric cut.

Ein Verfahren zum Anzeigen des Kohlendioxidgehalts geschnittenen klimakterischen Obsts oder Gemüses, welches die Lagerung frischer Lebensmittel betrifft. Erfindungsgemäss werden Früchte von Myrica rubra entsteint, wobei zunächst Ultraschall zur Extraktion sauren Wassers sowie zur Alkoholpräzipitation und AB-8-Harz zum Reinigen eingesetzt werden, um eine Lösung natürlichen Pigments zu erhalten, deren pH-Wert auf 5 bis 6 eingestellt wird. Ein Baumwollfaserpapier wird in die Lösung natürlichen Pigments getaucht, daraus entnommen und getrocknet, um ein Baumwollfaserpapier mit einer angehafteten Schicht natürlichen Pigments zu erhalten. Gleichzeitig wird die Lösung natürlichen Pigments mit einer Methylzellulose und einem Glyzerin durchgemischt, auf eine Platte gegossen und getrocknet, um die Schicht natürlichen Pigments zu bilden. Die Schicht natürlichen Pigments und das Baumwollfaserpapier, an dessen Oberfläche die Schicht natürlichen Pigments angehaftet ist, werden mit einer Schicht einer ...

Method for displaying the sound fruit or vegetable carbon dioxide a freshly cut climacteric.

Ein Verfahren zum Anzeigen des Kohlendioxidgehalts geschnittenen klimakterischen Obsts oder Gemüses, welches die Lagerung frischer Lebensmittel betrifft. Erfindungsgemäss werden Früchte von Myrica rubra entsteint, wobei zunächst Ultraschall zur Extraktion sauren Wassers sowie zur Alkoholpräzipitation und AB-8-Harz zum Reinigen eingesetzt werden, um eine Lösung natürlichen Pigments zu erhalten, deren pH-Wert auf 5 bis 6 eingestellt wird. Ein Baumwollfaserpapier wird in die Lösung natürlichen Pigments getaucht, daraus entnommen und getrocknet, um ein Baumwollfaserpapier mit einer angehafteten Schicht natürlichen Pigments zu erhalten. Gleichzeitig wird die Lösung natürlichen Pigments mit einer Methylzellulose und einem Glyzerin durchgemischt, auf eine Platte gegossen und getrocknet, um die Schicht natürlichen Pigments zu bilden. Die Schicht natürlichen Pigments und das Baumwollfaserpapier, an dessen Oberfläche die Schicht natürlichen Pigments angehaftet ist, werden mit einer Schicht einer ...

SENSITIVE SYSTEM FOR DETECTING CHEMICAL AND/OR PHYSICAL STATE CHANGES INSIDE PACKAGED MEDIA

The invention relates to a sensitive system for detecting chemical and/or physical state changes, preferably inside packages, of small sample volumes or a high-viscosity medium containing substances or the mixtures thereof. The aim of said invention is to make it possible to check at a low cost the state of said substances or the mixtures thereof or of different media. For this purpose, the inventive sensitive system is designed in such a way that a membrane or a sensitive film (1) is arrangeable on or in an element (3) which is interchangeably connectable to a cannula (2), thereby making it possible to introduce the element (3) and the cannula (2) into a measurable medium and to form an optical connection with an optical sensor system (4).

ДИАГНОСТИЧЕСКИЙ ТЕСТ ДЛЯ РАСПОЗНАВАНИЯ СТАТУСА КУРЕНИЯ СУБЪЕКТА

Apparatus, system, and method for detecting a target substance

Described herein are apparatus, methods, and systems for detecting the presence of a targeted substance. The apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the apparatus can include a top layer coupled to a top surface of the detection layer and a bottom layer coupled to a bottom surface of the detection layer.

CUVETTE

CANADIAN PATENT APPLICATION OF JAN EVERT LILJA and SVEN ERIK LENNART NILSSON FOR CUVETTE This invention relates to a new disposable cuvette for essentially simultaneous sampling of a fluid and analysing the sample. The new cuvette comprises a body member having at least one cavity defined by surrounding walls, into which cavity the sample is permitted to enter by capillary force through an inlet communicating said cavity with the exterior of the body member. According to the invention, the cuvette is characterised in that at least a portion of the walls facing the cavity consists of a semipermeable membrane, optionally with an ihtegrated electrode and/or sensor system, and that at least one reagent or reagent system is incorporated in the cuvette.

Gas sensor, refrigerator including same and control method therefor

Method for quickly detecting content of 5-hydroxytryptophan

CUVETTE

SURFACE LAYER, PREFERABLY FOR SAMPLE-LATERAL MOUNTING AT OPTICAL ION SENSORS

DECKSCHICHT, VORZUGSWEISE ZUR PROBENSEITIGEN ANBRINGUNG AN OPTISCHEN IONENSENSOREN

Ammonia sensor and system for use

An ammonia gas sensing device includes a housing defining a fluid flow path. The fluid flow path includes a fluid inlet, a fluid outlet, and an access port. A gas permeable/liquid impermeable membrane is mounted on and sealed against the housing at the access port such that the membrane is exposed to the fluid flow path but fluid is blocked from flowing outward of the access port around rather than through the membrane. An ammonia sensor is mounted on the housing at the access port in a position outward of the membrane. A system for using the ammonia sensing device includes the ammonia gas sensing device, a light source directed at the ammonia sensor, a photo detector to measure the light reflected off the ammonia sensor from the light source, and a controller for controlling the light source and optical sensor.

Calibrator for a sensor

A calibrator, for calibrating a sensor, has a calibration chamber for containing a calibration liquid. The liquid comprises water or an aqueous solution of an analyte to be sensed. A hydrogen peroxide-quenching material is provided exposed to the interior of the calibration chamber. The hydrogen peroxide-quenching material contacts the calibration liquid. After the calibration chamber containing the calibration liquid is sterilized by irradiation with gamma radiation, the hydrogen peroxide-quenching material decomposes any hydrogen peroxide formed in the calibration liquid to avoid adverse effects on a sensor placed in contact with the calibration liquid.

GLUCOSE SENSOR

An optical glucose sensor may include an optical fiber and a glucose-permeable membrane having a hollow interior and being coupled to the optical fiber's distal end. The membrane's hollow interior provides a compartment to house a competitive glucose binding affinity assay. The assay may include a glucose analog that may be labeled with a dye, and a glucose receptor that may be labeled with a fluorophore. The optical fiber may include a compound parabolic concentrator tip, and the compartment may additionally house a reflector disposed so as to face the optical fiber's tip. A fluorophore-labeled assay may be interrogated by an optical interrogating system including a light source and a filter substrate having one or more coatings to effect, e.g., an excitation filter and/or an emission filter. The interrogating system may be manufactured as a stacked planar integrated optical system and diced into smaller units.

APPARATUS, SYSTEM, AND METHOD FOR DETECTING A TARGET SUBSTANCE

Described herein are apparatus, methods, and systems for detecting the presence of a targeted substance. The apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the apparatus can include a top layer coupled to a top surface of the detection layer and a bottom layer coupled to a bottom surface of the detection layer.

ORTHOGONALLY REDUNDANT SENSOR SYSTEMS AND METHODS

A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be ...

Hydrogen peroxide plasma sterilization indication method

OPTOCHEMICAL SENSOR

The invention relates to an optochemical sensor (1) comprising a polymer matrix which is applied to a substrate (4) and which is doped with a luminescent colorant, the emissivity of which can be modified after excitation with electromagnetic radiation by substances to be detected such as gaseous or dissolved O2, SO2, H2O2, CO2, nitrogen oxides and halogenated hydrocarbons, which polymer matrix forms a sensor layer that is also covered by an optical insulating and protective layer (7) which can be permeated by the substance to be analysed. In the optochemical sensor, the sensor layer is formed from a layer which has an insular sensor element or a plurality of mutually separated sensor elements (2), the at least one sensor element (2) being covered by a non-doped polymer matrix (3) which chemically corresponds to the polymer matrix of the sensor layer.

BIOSENSING SYSTEMS FOR MEASUREMENT OF LACTOSE

Herein disclosed are biosensing systems that measure lactose concentration in a solution.

Optical gas sensor for use with electrical equipment and methods of assembling same

A method and apparatus for detecting a gas in electrical equipment by coupling a gas detection device to the electrical equipment is provided. The method includes providing an electro-magnetic source, positioning an electro-magnetic detector to receive light emitted from the electro-magnetic source, and positioning a membrane between the electro-magnetic source and the electro-magnetic detector, such that the electro-magnetic detector only receives light from the electro-magnetic source that has been transmitted through the membrane. The method also includes detecting at least one gas, such that detection of at least one gas includes preventing or allowing communication of the electro-magnetic source and the electro-magnetic detector, and emitting a signal, by the electro-magnetic detector, in response to the detection of the at least one gas.

HYDROGEN SENSOR HAVING A PROTECTION LAYER

A hydrogen sensor for detecting hydrogen in a fluid in physical contact with the sensor comprises a sensing element, a first protection layer, provided to prevent contact of the sensing element with a sensor poisoning gas in the fluid, wherein the first protection layer comprises PMMA. Further, a hydrogen detection system, an electrical device having such a system and a method for producing a sensor are provided.

Messmembran für einen optochemischen oder amperometrischen Sensor

Die Erfindung betrifft eine Messmembran (8) für einen optochemischen oder amperometrischen Sensor zur Bestimmung oder Überwachung eines in einem Medium befindlichen Analyten (12) mit einem Sensorelement (3), das zumindest eine Funktionsschicht (4) mit einer sensorspezifischen Substanz (18) aufweist, und einem Substratmaterial (2), wobei das Sensorelement (3) vollumfänglich in eine Matrix (9) eingebettet ist, und wobei die Matrix (9) aus einem Material besteht, das zumindest in einem dem Medium (11) zugewandten und an das Sensorelement (3) angrenzenden Teilbereich für den Analyten (12) durchlässig ist.

SURFACE LAYER, PREFERABLY FOR SAMPLE-LATERAL MOUNTING AT OPTICAL ION SENSORS

SENSOR SYSTEM.

PROCEDURE FOR THE MEASUREMENT OF THE CARBON DIOXIDE CONCENTRATION IN A MEDIUM

Opto-chemischer Sensor

Bei einem opto-chemischen Sensor (1), umfassend eine auf einem Träger (4) aufgebrachte Polymermatrix (3), welche mit einem Lumineszenzfarbstoff dotiert ist, dessen Emissionsvermögen nach einer Anregung mit elektromagnetischer Strahlung durch nachzuweisende Substanzen, wie gasförmiges oder gelöstes O2, SO2, H2O2 CO2, Stickoxide, halogenierte Kohlenwasserstoffe veränderbar ist und welche eine Sensorschicht ausbildet, welche weiterhin mit einer für die zu analysierende Substanz durchlässigen, optischen Isolier- bzw. Schutzschicht (7) abgedeckt ist, ist die Sensorschicht aus einer eine Mehrzahl von voneinander getrennten Sensorelementen (2) aufweisenden Schicht gebildet ist, welche Sensorelemente (2) von einer chemisch der Polymermatrix der Sensorschicht entsprechenden, nicht dotierten Polymermatrix (3) überdeckt sind.

Opto-chemischer Sensor

Bei einem opto-chemischen Sensor (1), umfassend eine auf einem Träger (4) aufgebrachte Polymermatrix (3), welche mit einem Lumineszenzfarbstoff dotiert ist, dessen Emissionsvermögen nach einer Anregung mit elektromagnetischer Strahlung durch nachzuweisende Substanzen, wie gasförmiges oder gelöstes 02 , S02 , H202 , C02 , Stickoxide, halogenierte Kohlenwasserstoffe veränderbar ist und welche eine Sensorschicht ausbildet, welche weiterhin mit einer für die zu analysierende Substanz durchlässigen, optischen Isolier- bzw. Schutzschicht (7) abgedeckt ist, ist die Sensorschicht aus einer eine Mehrzahl von voneinander getrennten Sensorelementen (2) aufweisenden Schicht gebildet ist, welche Sensorelemente (2) von einer chemisch der Polymermatrix der Sensorschicht entsprechenden, nicht dotierten Polymermatrix (3) überdeckt sind.

GLUCOSE SENSOR

An optical glucose sensor may include an optical fiber and a glucose-permeable membrane having a hollow interior and being coupled to the optical fiber's distal end. The membrane's hollow interior provides a compartment to house a competitive glucose binding affinity assay. The assay may include a glucose analog that may be labeled with a dye, and a glucose receptor that may be labeled with a fluorophore. The optical fiber may include a compound parabolic concentrator tip, and the compartment may additionally house a reflector disposed so as to face the optical fiber's tip. A fluorophore-labeled assay may be interrogated by an optical interrogating system including a light source and a filter substrate having one or more coatings to effect, e.g., an excitation filter and/or an emission filter. The interrogating system may be manufactured as a stacked planar integrated optical system and diced into smaller units.

COATING MATERIAL AND A FIBER OPTIC SENSOR IN WHICH THIS COATING MATERIAL IS USED

This invention relates to a coating material comprising of sensor material affected by the changes in humidity, temperature, pressure and other similar quantities, and, because of this characteristic of sensor material, a binding group enabling the coating of the sensor material used in fiber optic sensors (1) on organic or inorganic surface with an adhesive effect, and a fiber optic sensor(1) where this coating material is used.

PROCESS AND APPARATUS FOR MEASURING THE CONCENTRATION OF COMPOSITION DURING FERMENTATION PROCESS

An apparatus (100) for measuring the concentration of composition during fermentation process comprises a sample line (104), a reagent line (105), the configuration of which is so designed that the both lines at least partly overlap each other to form a chamber, a dialysis membrane (103) mounted between the sample line (104) and the reagent line (105), allowing the sample to be analysed in the fermentation liquor sample to diffuse from said sample line (104) to said reagent line (105), to make said sample to be analysed and said reagent reaction, and an operating device (114) mounted in said reagent line to measuring optical absorption degree of reagent after response. A process for measuring the concentration of composition during fermentation process can be finished only by a small quantity of fermentation liquor sample and reagent.

Ammonia and ammonium sensors

A sensor which senses concentrations of a component of a fluid. In a dialysis system, the sensor can monitor the total ammonia and ammonium concentration in dialysate. The sensor has an optical indicator, such as an ammonia sensitive membrane, positioned in direct contact with the dialysate fluid when in use. The ammonia sensitive membrane has a variable optical indication, such as a variable color change, in relation to the concentration of ammonia in the dialysate. An optical reader reads the color change of the membrane to measure the total ammonia and ammonium concentration in the dialysate. The sensor can be used in the dialysis system to monitor the effectiveness of sorbants which remove ammonia/ammonium which is produced from an enzyme reaction with urea, the urea being removed from a patient during dialysis treatment.

Optochemical sensor unit and a method for the qualitative and/or quantitative determination of an analyte in a measuring medium with the sensor unit

An optochemical sensor unit including: an optical waveguide; a transmitting unit for emitting a first transmission signal for exciting a luminophore; a receiving unit for receiving a received signal comprising a signal component emitted by the excited luminophore; a measuring chamber for receiving a fluid, wherein the fluid includes magnetic microspheres; a membrane arranged between the measuring chamber and a measuring medium for exchanging an analyte between the measuring medium and the fluid in the measuring chamber, wherein the measuring diaphragm is impermeable to the magnetic microspheres; and an electromagnet for attracting magnetic microspheres to a sensor membrane with a fluid-contacting surface and/or to a fluid-contacting surface of the optical waveguide, or to a surface of a transparent substrate layer of the optical sensor unit that is connected to the optical waveguide.

Funktionsschichtträger und Sensorsystem umfassend einen derartigen Funktionsschichtträger

Die Erfindung betrifft ein einen Funktionsschichtträger für den Einsatz in einem Sensorsystem, ein Sensorsystem, welches den Funktionsschichtträger nutzt, sowie die Verwendung des Sensorsystems mit dem Funktionsschichtträger als Detektionssystem in einem photonischen und / oder nicht-photonischen Messprinzip. Die Aufgabe einen Funktionsschichtträger anzugeben, der einen kompakten und miniaturisierten Aufbau von Multiparametersensoren, insbesondere für optische Sensoren erlaubt, wobei derartige Systeme für den Einsatz in Gasen und Flüssigkeiten einsatzfähig sein sollen, wird durch einen Funktionsschichtträger gelöst, der mindestens eine Funktionsschicht, welche eine sensorsystemseitige Oberfläche und eine zum Kontakt mit einem Messmedium vorgesehene dem Messmedium zugewandte medienseitige Oberfläche zur Bestimmung von mindestens einem chemischen und/oder physikalischen Parameter in dem Messmedium aufweist, umfasst, wobei die Funktionsschicht mindestens einen aktiven Bereich aufweist und ...

METHODS AND APPARATUS FOR DETECTING COMPOUNDS IN LIQUIDS

Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line. Specific buffers are disclosed, and these buffers may be used in the preparation of the apparatus to overcome challenges associated with miniaturization and challenges associated ...

ORTHOGONALLY REDUNDANT SENSOR SYSTEMS AND METHODS

A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be ...

SENSOR ELEMENT AND METHOD FOR MAKING THE SAME

A sensor element includes an analyte-permeable matrix which supports and maintains an emulsion of a sensing solution containing an analyte-sensitive indicator substance in a plurality of tiny vesicles. The sensing solution is immiscible with the matrix material, and contains a dye indicator which dissociates into two different species. The sensing solution is initially mixed with an agent which modifies the equilibrium of dissociation of the dye indicator for optimal sensitivity. The liquid matrix preferably includes a curing inhibitor to allow the matrix to remain liquid until applied to a sensing surface, such as the tip of an optical fiber. The sensing solution remains suspended in these homogeneously dispersed vesicles after the matrix solidifies.

OPTICAL SENSOR AND METHOD FOR INDICATING THE AGE OR QUALITY OF A NATURAL PRODUCT

Sensor system

SYSTEMS AND METHODS FOR NON-INVASIVE DETERMINATION OF COVID-19 CORONAVIRUS INFECTION

Chemische Sensorvorrichtung und Verfahren zur Ermittlung der Konzentration von in einem flüssigen Analyten gelösten Ionen

Die vorliegende Erfindung betrifft eine Sensorvorrichtung zur Ermittlung der Konzentration von in einem flüssigen Analyten enthaltenen Ionen mittels wenigstens einer in den Analyten eintauchbaren, ionenselektiven Membran (215, 215', 220) sowie ein Verfahren zu ihrem Betrieb, welche insbesondere wenigstens eine Lichtquelle (200, 205, 200', 205'), die Licht wenigstens einer Wellenlänge erzeugt, wenigstens einen Lichtsensor (225, 225', 230), mittels dessen in die ionenselektive Membran (215, 215', 220) eingestrahltes Licht der wenigstens einen Wellenlänge unter Nutzung des photoelektrischen Effekts in ein elektrisches Signal umwandelbar ist, und Rechenmittel zur Berechnung der Konzentration der in dem Analyten enthaltenen Ionen anhand der Kinetik des erfassten elektrischen Signals aufweist.

Eine optochemische Sensoreinheit und ein Verfahren zur qualitativen und/oder quantitativen Bestimmung eines Analyten in einem Messmedium mit der Sensoreinheit

Die Erfindung betrifft eine optochemische Sensoreinheit (1) umfassend einen Lichtwellenleiter (10), eine Sendeeinheit (6) zum Aussenden eines ersten Sendesignals zur Anregung eines Luminophors, eine Empfangseinheit (8) zum Empfang eines Empfangssignals umfassend einen durch das angeregte Luminophor ausgesandten Signalanteil,wobei die Sensoreinheit (1) einen Messraum (15) zur Aufnahme eines Fluids aufweist, wobei das Fluid (50) magnetische Mikrosphären umfasst,wobei die Sensoreinheit (1) eine Membran (20) aufweist, welche zwischen dem Messraum (15) und einem Messmedium (21) angeordnet ist und welche vorgesehen ist zum Austausch eines Analyten zwischen Messmedium (21) und dem Fluid (50) im Messraum (15), wobei die Membran (20) impermeabel für die magnetischen Mikrosphären (30) ist,wobei die Sensoreinheit (1) einen Elektromagneten (14 oder 104) aufweist, welcher vorgesehen ist zur Anziehung magnetischer Mikrosphären (30) zu einer Sensormembran (11) des optochemischen Sensors (1) mit fluidberührender ...

Device and methods of using device for detection of hyperammonemia

The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflunnated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care biosensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes.

SENSOR SYSTEM

Reagent used for detecting content of lead in food, and preparation method thereof

Bioluminescent packaging

Some embodiments provided herein relate to bioluminescent packaging, methods of making, and methods of sensing the state of a material. In some embodiments, light emitted by a bioluminescent organism can be used to sense the state of a material.

Optical gas sensor for use with electrical equipment and method for detecting gas in electrical equipment using said gas sensor

An apparatus for use in detecting gaseous bi-products (23), in particular hydrogen gas (23), in electrical equipment, such as an oil-cooled transformer (20), is provided. The apparatus includes a light source (13), a photocell (14), and a membrane (12) interposed between the light source (13) and the photocell (14), such that interaction of the membrane (12) and a gaseous bi-product (23) at least one of prevents and allows light communication between the light source (13) and the photocell (14).

DETERMINING PH BY FLUORESCENT INDICATORS

SENSOR ELEMENT AND METHOD FOR MAKING THE SAME

A sensor element 10 includes an analyte-permeable matrix 16 which supports and maintains a sensing solution containing an analyte-sensitive indicator substance in a plurality of tiny vesicles 18. The sensor element is prepared by combining the sensing solution with an emuslifier that renders the solution dispersed within the matrix material. The sensing solution remains suspended in these dispersed vesicles after the matrix solidifies. A sensor element made in accordance with the present invention may be placed at the end of an optical fiber 14.

WEARABLE APPARATUS FOR DETECTING A TARGET SUBSTANCE IN A LIQUID

Described herein are a wearable apparatus and methods for detecting the presence of a targeted substance in a liquid. For example, the wearable apparatus can be a fingernail that detects illicit drugs in a beverage. The wearable apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the wearable apparatus can include a lateral flow assay.

SENSOR ASSEMBLY AND METHOD FOR DETERMINING THE HYDROGEN AND MOISTURE CONTENT OF TRANSFORMER OIL

A sensor assembly 10 for sensing a hydrogen and moisture content of insulation liquid 2 of a liquid-filled electrical equipment based on radiation detection is provided. The sensor assembly comprises at least one electromagnetic radiation source 60 for emitting electromagnetic radiation; a water detection section 20 arranged for receiving at least a water-containing component 2a of the insulation liquid when the sensor assembly is in operational connection with the electrical equipment and for being illuminated by electromagnetic radiation from the at least one electromagnetic radiation source 60; a first electromagnetic radiation detector 30 configured for detecting electromagnetic radiation coming from the water detection section 20 at a wavelength indicative of an amount of water present at the water detection section; a hydrogen detection section 40 arranged for receiving at least a hydrogen-containing component 2b of the insulation liquid when the sensor assembly is in operational ...

GLUCOSE SENSOR

An optical glucose sensor may include an optical fiber and a glucose-permeable membrane having a hollow interior and being coupled to the optical fiber's distal end. The membrane's hollow interior provides a compartment to house a competitive glucose binding affinity assay. The assay may include a glucose analog that may be labeled with a dye, and a glucose receptor that may be labeled with a fluorophore. The optical fiber may include a compound parabolic concentrator tip, and the compartment may additionally house a reflector disposed so as to face the optical fiber's tip. A fluorophore-labeled assay may be interrogated by an optical interrogating system including a light source and a filter substrate having one or more coatings to effect, e.g., an excitation filter and/or an emission filter. The interrogating system may be manufactured as a stacked planar integrated optical system and diced into smaller units.

BARRIER LAYER FOR GLUSOSE SENSOR

Analytical sensor comprising silicone membrane on end of fibre optic - held in carrier tube, for measuring oxygen@ concn. in fermentation from quenching of fluorescent dye dissolved in the membrane

Sensor arrangement for determn. of an analyte comprises: (1) a light conductor (fibre optic) set in a carrier; and (2) on the front of the conductor, a sensor consisting of a silicone membrane in which is dissolved a fluorescence indicator (I). The membrane is stretched over a transparent holder (pref. convex on its front side) mounted on the front end of the conductor. (I) is pyrene-butyric acid, decacylene or a Ru complex. USE/ADVANTAGE - The sensor is used to monitor the O2 concn. in fermentation processes based on increased quenching of fluorescence emission from (I) as the O2 concn. increases. It can be operated without supervision and the sensor is easily exchanged.

Cobalt-nickel nanowire array as well as preparation method and application thereof

Reagent for rapidly detecting paraquat, and preparation method and application thereof

Solid powder detecting agent for determining ammonium nitrogen content

Method for detecting amine collector by spectrophotometric method

COATING MATERIAL AND A FIBER OPTIC SENSOR IN WHICH THIS COATING MATERIAL IS USED

This invention relates to a coating material comprising of sensor material affected by the changes in humidity, temperature, pressure and other similar quantities, and, because of this characteristic of sensor material, a binding group enabling the coating of the sensor material used in fiber optic sensors (1) on organic or inorganic surface with an adhesive effect, and a fiber optic sensor (1) where this coating material is used.

Long period grating sensor methods and apparatus

The invention relates to optical sensors and systems and methods employing the sensors for detecting one or more compounds of interest in a test medium. In one embodiment an optical sensor comprising a long period grating and a solid phase microextraction (SPME) film is exposed to a test medium such that one or more compounds of interest are selectively partitioned into the solid phase microextraction film. At least one optical property of the sensor exposed to the test medium is compared with at least one corresponding optical property of the sensor in absence of the test medium; wherein a difference in the optical property is indicative of one or more compounds of interest in the test medium. The methods and systems may employ long period grating sensors with or without SPME films, and fiber loop ring-down spectroscopy to measure optical properties of the sensor.

CHEMOSENSING HYDROGEL FOR THE DETECTION OF BIOGENIC AMINES

A chemosensing hydrogel is provided that undergoes a colorimetric reaction in response to the detection of a biogenic amine vapor, such as a biogenic amine vapor that is a by-product resulting from food spoilage. In an embodiment, an apparatus for detection of biogenic amines, is provided that includes a hydrogel having a bimetallic iron(II)-iron(III) complex disposed within the hydrogel, wherein the hydrogel is configured to change from a first color to a second color in response to exposure to a biogenic amine.

Membrane and method of manufacture

The present disclosure concerns a membrane for a sensor, such as an opto-chemical or electrochemical sensor, including a polymer layer, for example, one featuring pores or openings, that is permeable to a measuring fluid and/or an analyte contained in the measuring fluid, with a surface designed to be in contact with a measuring fluid, wherein the surface is designed such that, at least in a moist condition of the polymer layer obtained by moistening the surface, a contact angle of a water drop applied to the surface is less than 50°, including less than 30°, and including less than 10°.

Sensor system

A sensor system for determining the pH or carbon dioxide concentration of a liquid medium comprising, in combination, a pH-insensitive fluorescent indicator and a pH-sensitive fluorescent indicator which act in concert or a single fluorescence indicator which emits fluorescent signals of different wavelengths in different carriers, which system(s) produce diverging signals, the ratio of which provides an accurate and stable determination of the parameter being measured. A method for determing pH and CO2 concentration is also disclosed.

Charakterisieren einer Fluidprobe auf Grundlage einer Reaktion einer nicht planbaren Struktur

Hierin werden Vorrichtungen, Verfahren und ein Speichermedium offenbart, die mit einem Charakterisieren einer Fluidprobe auf Grundlage einer Reaktion einer nicht planaren Struktur verbunden sind. In Ausführungsformen kann eine Vorrichtung eine nicht planare Struktur enthalten, die ein Äußeres (z. B. ein gewölbtes Äußeres) und einen Kern mit einem Inhalt aufweist, der sich als Reaktion auf ein Auftragen der Fluidprobe auf die nicht planare Struktur (z. B. durch Osmose) ändert. Die Vorrichtung kann einen oder mehrere Prozessoren, Einrichtungen und/oder Verschaltung enthalten, um auf Grundlage der Messung einen Wert zu identifizieren, der auf eine Kenngröße des Fluids hinweist. Weitere Ausführungsformen können offenbart und beansprucht werden.

Ammonia sensor and system for use

Wearable apparatus for detecting a target substance in a liquid

Described herein are a wearable apparatus and methods for detecting the presence of a targeted substance in a liquid. For example, the wearable apparatus can be a fingernail that detects illicit drugs in a beverage. The wearable apparatus comprises a detection layer comprising an indicator that is configured to display a signal upon the detection of an interaction with the targeted substance. In some examples, the wearable apparatus can include a lateral flow assay.

LONG PERIOD GRATING SENSOR METHODS AND APPARATUS

OPTICAL METHOD AND SYSTEM FOR MEASURING AN ENVIRONMENTAL PARAMETER

An optical system for sensing an environmental parameter, comprising: a pulse generator for generating a first pulse having a first wavelength and a second pulse having a second wavelength; a pulse splitter for splitting each one of the first and second pulse into a sensing pulse and a reference pulse; a sensing arm for receiving the sensing pulses therefrom and comprising a spectro-ratiometric sensor; a reference arm for receiving the reference pulses; a time delay line for delaying a relative propagation of the sensing pulses and the reference pulses; a light detector for measuring an optical energy of the sensing pulse and the reference pulse, for the first and second wavelengths; and at least one optical link for optically connecting the pulse generator to the pulse splitter, and the sensing and reference arms to the light detector.

CHARACTERIZING A FLUID SAMPLE BASED ON RESPONSE OF A NON-PLANAR STRUCTURE

Urine detection reagent

BIOLUMINESCENT PACKAGING

Disclosed herein is a bioluminescent packaging material, comprising a bioluminescent organism, such as Vibrio fischeri, immobilised on a matrix. In some embodiments, the bioluminescent organism is configured to emit a bioluminescent response to the state of the material contained in the packaging, for example food spoilage, temperature, or humidity. Also disclosed is a method of manufacturing a bioluminescent packaging, comprising the steps of culturing a bioluminescent organism and inducing it into a metabolically quiescent state, incorporating the quiescent organisms into the matrix, and making a packaging comprising the matrix. Suitable materials for the matrix include starch, carbohydrates, proteins, synthetic polymers and hydrogels.

SYSTEM AND METHOD FOR MEASURING OXYGEN IN THE PRESENCE OF HALOTHANE

SYSTEM AND METHOD FOR MEASURING OXYGEN IN THE PRESENCE OF HALOTHANE The system for measuring the concentration of oxygen in a fluid sample which may also contain halothane includes a sensor having a matrix containing a first indicator dye which fluoresces at a known wavelength when irradiated with light of a specific wavelength and containing a second indicator dye which fluoresces at a different emission wavelength upon irradiation with light of a similar or different specific wavelength. The fluorescence of the first and second indicator dyes are quenched to a different degree by the presence of oxygen, but the fluorescence of the indicator dyes is quenched to the same degree by halothane. Means are provided for irradiating the indicator dyes in the matrix with the appropriate wavelengths of light, and means are provided for measuring the resultant intensity of fluorescence of the indicator dyes at the different wavelengths of fluorescence. Means are also provided for determining the ...

CUVETTE

Lead-free indicator for pressure steam sterilization and preparation method thereof

Methods and apparatus for detecting compounds in liquids

Described herein are apparatus and methods for detecting substances of abuse or other analytes in liquids. For example, the apparatus and methods described herein can be used for real-time detection of analytes, such as substances of abuse. The methods comprise providing a detection area comprising a chromatographic membrane capable of receiving the liquid and allowing for migration of the liquid, the chromatographic membrane comprising an anti-analyte antibody-particle conjugate, an analyte-conjugate protein at a test line; exposing at least the first location of the apparatus to the liquid; and determining whether an interaction between the analyte-conjugate protein and the liquid occurs to detect the presence of the analyte. The chromatographic membrane may further comprise an anti-species antibody at a control line. Specific buffers are disclosed, and these buffers may be used in the preparation of the apparatus to overcome challenges associated with miniaturization and challenges associated ...

CHEMICAL- PHYSICAL SENSING DEVICE FOR CHEMICAL - TOXICOLOGICAL DIAGNOSTICS IN REAL MATRICES

The present invention relates to a detecting device (1) for detecting contaminant and/or composition chemical agents, particularly in an environmental liquid, a food or a biologic fluid, comprising: - a housing (2), - at least one material (MSI, MS2) responsive to at least one contaminant and/or composition chemical agent, - supporting means (3) for supporting said at least one material, - a detection unit (8) for detecting said contaminant and/or composition chemical agent through changes in optical and/or electrical properties of said material, - at least a light source or emitter (4) for emitting one or more luminous radiation on said responsive material, - an optical receiver (5) for receiving the light radiation reflected from said material and/or emitted by it, and - a pair of electrodes (6, 7; 6', 7'), each of which has one end in contact with said material, and the other end electrically connected to said detection unit (8).

LONG PERIOD GRATING SENSOR METHODS AND APPARATUS

METHOD FOR MEASURING THE CONCENTRATION OF CARBON DIOXIDE IN A MEDIUM

Simple detection reagent for cervical cell watt-cell effect as well as preparation method and application thereof

BIOSENSING SYSTEMS FOR MEASUREMENT OF LACTOSE

Herein disclosed are biosensing systems that measure lactose concentration in a solution.

OPTICAL SENSOR AND METHOD FOR INDICATING THE AGE OR QUALITY OF A NATURAL PRODUCT

The present invention relates to the field of analyzing the age and/or quality of certain natural products, for example foods. The invention also relates to devices for analyzing said age and/or quality as well as to methods for preparing such devices, to methods for analyzing natural products and to their use.

DIAGNOSTIC TEST FOR DISTINGUISHING THE SMOKING STATUS OF A SUBJECT

There is disclosed herein a device for determining the smoking status of a subject, wherein said device comprises a plurality of different specific binding molecules deposited to a solid phase to detect specifically the presence of two or three tobacco smoke exposure biomarkers in a biological sample, said biomarkers consisting of: (i) cotinine and total 4-(methylnitrosamino)-1-(3-, pyridyl)-1-butanol (NNAL); (ii) cotinine and N-acetyl-S-[2-carboxyethyl]-L-cysteine (CEMA); or (iii) cotinine and NNAL and CEMA. 115-. (canceled)16. A device for determining the smoking status of a subject , wherein said device comprises a plurality of different specific binding molecules deposited onto a solid phase to detect the presence of two or three tobacco smoke exposure biomarkers in a biological sample , said tobacco smoke exposure biomarkers consisting of:(i) cotinine and total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL); or(ii) cotinine and N-acetyl-S-[2-carboxyethyl]-L-cysteine (CEMA); or(iii) cotinine and total NNAL and CEMA.17. The device according to claim 16 , wherein the device is a portable lateral flow immunoassay device claim 16 , preferably claim 16 , a dipstick claim 16 , configured to perform a competitive immunoassay.18. The device according to claim 16 , wherein the portable lateral flow immunoassay device comprises: (i) a sample pad; (ii) a conjugate pad; and (iii) at least one detection zone.19. The device according to claim 18 , wherein the conjugate pad comprises or consists of labelled specific binding agents each capable of individually binding: (i) cotinine and total NNAL; or (ii) cotinine and CEMA; or (iii) cotinine and total NNAL and CEMA claim 18 , suitably claim 18 , wherein each of the labelled specific binding agents is an antibody or fragment thereof claim 18 , an aptamer claim 18 , a photoaptamer claim 18 , an affimer claim 18 , a protein claim 18 , a peptide claim 18 , a peptidomimetic or a small molecule.20. The device according to claim ...

SENSORSYSTEM.

Sensorkappe für einen optochemischen Sensor und entsprechender optochemischer Sensor

Die Erfindung betrifft eine Sensorkappe (2) für einen optochemischen Sensor (1) zur Bestimmung oder Überwachung zumindest eines in einem Medium (3) befindlichen Analyten (4), mit einer im Wesentlichen zylinderförmigen Einschubkomponente (5) und einer hülsenförmigen Außenkomponente (6), wobei die Einschubkomponente (5) in dem dem Medium (3) zugewandten Endbereich eine optische Komponente (7) mit einem strömungsoptimiert, bevorzugt konvex geformten Oberflächenbereich (8) aufweist, wobei die optische Komponente (7) im Bereich des strömungsoptimiert geformten Oberflächenbereichs (8) zumindest teilweise aus einem für Messstrahlung transparenten Material besteht, wobei auf dem konvex geformten Oberflächenbereich (8) der optischen Komponente (7) eine Analyt-sensitive Matrix (11) oder eine Analyt-sensitive Membran vorgesehen ist, die zumindest eine Funktionsschicht (12, 13, 14) mit einer für den Analyten (4) sensitiven Substanz aufweist, wobei die Einschubkomponente (5) und die hülsenförmige Komponente ...

Barrier layer for glucose sensor

An optical glucose sensor comprising: a sensing region comprising a boronic acid receptor for binding to glucose and a fluorophore associated with said receptor; an optical waveguide for directing incident light onto the sensing region; and a hydrophilic, polymeric, glucose-permeable barrier layer which is provided on at least a part of the sensing region; wherein the sensor is adapted so that glucose enters the sensing region of the sensor through said barrier layer.

Covalent organic skeleton material capable of changing color when meeting water, preparation method thereof and application

Method for rapidly determining peroxide value of edible oil

CALIBRATOR FOR A SENSOR

A calibrator, for calibrating a sensor, has a calibration chamber for containing a calibration liquid. The liquid comprises water or an aqueous solution of an analyte to be sensed. A hydrogen peroxide-quenching material is provided exposed to the interior of the calibration chamber. The hydrogen peroxide-quenching material contacts the calibration liquid. After the calibration chamber containing the calibration liquid is sterilized by irradiation with gamma radiation, the hydrogen peroxide-quenching material decomposes any hydrogen peroxide formed in the calibration liquid to avoid adverse effects on a sensor placed in contact with the calibration liquid.

Pressurized membrane chemical sensor

A fiber optic based chemical sensor detects chemical species in solution. A fluorogenic indicator is forced through an ultrafiltration membrane into an analyte solution. Complex formation between indicator molecules and target ions occurs at the membrane-solution interface where light from a bifurcated fiber optic cable stimulates fluorescence. Fluorescent emission from a sample is transmitted back up the fiber optic cable to a linear photo diode detector. The sensor responds linearly to increasing and decreasing concentration changes on time scales of one second. Chemical modification of an indicator solution enhanced sensitivity.

Coating material and fiber optic sensor in which this coating material is used

This invention relates to a coating material that is applied on organic and/or inorganic surfaces and that can detain moisture and easily release the moisture that is detained after a certain time, and a fiber optic sensor (1) where this coating is utilized.

AMMONIA SENSOR AND SYSTEM FOR USE

Reagent for visually detecting hypochlorite quickly

APPARATUS, SYSTEM, AND METHOD FOR DETECTING A TARGET SUBSTANCE

IN VITRO POINT-OF-CARE SENSOR AND METHOD OF USE

An in vitro sensor for point-of-care detection of at least one analyte or reaction product includes an inert, impermeable substrate, a sensing system, and a reference system. The substrate includes a first transparent surface oppositely disposed from a second surface and first and second cavities. Each of the first and second cavities defines an opening at the second surface. The sensing system is disposed in at least a portion of the first cavity and includes an analyte-detection optode membrane, an analyte-permeable membrane, and a plurality of non-transparent microbeads associated with at least one of the analyte-detection optode membrane and the analyte-permeable membrane. The analyte-permeable membrane is layered upon the analyte-detection optode membrane and covers the opening of the first cavity. The reference system is disposed in at least a portion of the second cavity.

CHEMICALLY-STABLE SENSOR

The invention relates to a sensing unit (1) comprising a housing (2) that has a first housing opening which can be oriented towards a medium (M) to be analysed, and a second housing opening on which at least one means for detachably rigidly connecting to a sensor shaft or sensor housing are arranged, or may be arranged, on the inner and/or outer side; at least one sensor element (3) that is arranged in the housing (2) and comprises indicators and, optionally, indicator protectors, said sensor element (3) having a first side facing the first housing opening and a second side lying opposite the first housing opening; and at least one protector element (4) which is arranged in the region of the first housing opening between the at least one sensor element (3) and the medium (M) which surrounds the sensing unit (1), particularly in the region of said housing opening, such that the sensor element (3) does not come into direct contact with the medium (M).

Optical sensing systems and methods

An optical glucose sensor may include an optical fiber and a glucose-permeable membrane having a hollow interior and being coupled to the optical fiber's distal end. The membrane's hollow interior provides a compartment to house a competitive glucose binding affinity assay. The assay may include a glucose analog that may be labeled with a dye, and a glucose receptor that may be labeled with a fluorophore. The optical fiber may include a compound parabolic concentrator tip, and the compartment may additionally house a reflector disposed so as to face the optical fiber's tip. A fluorophore-labeled assay may be interrogated by an optical interrogating system including a light source and a filter substrate having one or more coatings to effect, e.g., an excitation filter and/or an emission filter. The interrogating system may be manufactured as a stacked planar integrated optical system and diced into smaller units.

SUBSTRATE-IMMOBILIZED OPTICAL NANOSENSORS

A sensor for detecting an analyte can include a photoluminescent nanostructure embedded in a sensor porous planar substrate. The sensor porous planar substrate can be supported by a substrate porous planar substrate. 1. A sensor for detecting one or more analytes , comprising:a porous planar substrate; andat least one photoluminescent nanostructure on or embedded within the sensor porous planar substrate.2. The sensor of claim 1 , further comprising an analyte-binding compound associated with the photoluminescent nanostructure.3. The sensor of claim 2 , wherein the photoluminescent nanostructure includes a polymer.4. The sensor of claim 3 , wherein the polymer includes a polypeptide claim 3 , a polynucleotide or a polysaccharide.5. The sensor of claim 3 , wherein the polymer is a polynucleotide.6. The sensor of claim 1 , further comprising a plurality of regions on the porous planar substrate claim 1 , at least one of the plurality of regions includes a first region including the at least one photoluminescent nanostructure.7. The sensor of claim 6 , wherein the plurality of regions includes a second region including at least one photoluminescent nanostructure different from the at least one photoluminescent nanostructure.8. The sensor of claim 6 , wherein the plurality of regions includes at least three distinct regions.9. The sensor of claim 1 , wherein the porous planar substrate is a paper claim 1 , nitrocellulose claim 1 , or nylon claim 1 , or combinations thereof.10. A method of making a sensor for detecting one or more analytes claim 1 , comprising:depositing a photoluminescent nanostructure on or within a porous planar substrate.11. The method of claim 10 , further comprising patterning the porous planar substrate to include a plurality of regions claim 10 , at least one region receiving the photoluminescent nanostructure.12. The method of claim 10 , wherein depositing includes placing a liquid including the photoluminescent nanostructure on the porous ...

METHODS AND SYSTEMS FOR DIAGNOSING SLEEP DISORDERS

Methods and compositions for risk detection, early diagnosis, prognosis, and monitoring of sleepiness in an individual by measuring the amount of specific biomarkers present in a bodily fluid and comparing them to a reference level of biomarkers in a sample from a healthy person, a person previously diagnosed with sleepiness, or an earlier sample from the individual of interest. 1. A method of diagnosing sleepiness , comprising:(a) collecting a saliva sample from an individual suspected of suffering a sleep disorder;(b) applying the saliva sample to a solid support on which at least two agents, each of which binds to a different single biomarker selected from arginine, creatine, dihomo-linoleate, tyrosine, beta-endorphin, chromogranin A, annexin I, BDNF, 3-methyl-1-oxo-butyrate, or linolenate have been affixed, and wherein each agent binds to the different single biomarker to form a measurable complex of a single biomarker;(c) measuring the measurable complex of each of the different single biomarkers to create an individual biomarker profile; and an arginine reference level greater than about 0.32 μmol/ml,', 'a creatine reference level greater about 0.47 μmol/ml,', 'a dihomo-linoleate reference level greater than about 34 μmol/ml,', 'a tyrosine reference level greater than about 0.57 μmol/ml,', 'a beta-endorphin reference level greater than about 1490 pg/ml,', 'a BDNF reference level greater than about 488 pg/ml,', 'a 3-methyl-oxobutyrate reference level greater than about 52 μmol/ml,', 'a linoleate reference level greater than about 36 μmol/ml,', 'chromogranin A reference level greater than about 3.3 μmol/mg protein, and', 'an annexin I reference level greater than about 55 ng/ml., '(d) comparing the individual biomarker profile to reference levels for each of the different single biomarkers, wherein the individual biomarker profile meeting two or more criteria in a group of criteria is indicative of the sleep disorder, the group of criteria consisting of2. The ...

SELF-FUSING SILICONE TAPE FOR SENSING HYDROGEN AND HYDROGEN SULFIDE GAS LEAKS

A gas-sensing pigment incorporated in a thin film indicator or tape that changes color upon exposure to hydrogen or hydrogen sulfide. The gas-sensing pigment is compounded together with a silicone polymer to produce a self-fusing silicone tape having a tensile strength of at least 700 psi, a tear resistance of at least 85 psi, and ultimate elongation of at least 300%. The gas-sending pigment includes chemochromic metal oxide particles of a tungsten oxide or a molybdenum oxide, and a catalyst having platinum, palladium, rhodium, nickel, or silver. The catalyst coating is applied to each metal oxide particle as nanoparticles of less than 30 nanometers in diameter, and the microparticles of chemochromic metal oxide material are less than 200 microns or 100 microns in diameter. 1. A self-sealing silicone tape having a tensile strength of at least 700 psi , a tear resistance of at least 85 psi , and ultimate elongation of at least 300% , comprising: a silicone polymer embedded with a mixture of (a) microparticles of chemochromic metal oxide particles selected from the group consisting of a tungsten oxide and a molybdenum oxide , coated with (b) nanoparticles of a catalyst selected from the group consisting of platinum , palladium , rhodium , nickel and silver; wherein the microparticles of chemochromic metal oxide material have a range of sizes less than 200 microns in diameter , and the catalyst nanoparticles have a range of sizes less than 30 nanometers in diameter.2. A film comprising a polymer embedded with a mixture of (a) microparticles of chemochromic metal oxide particles selected from the group consisting of a tungsten oxide and a molybdenum oxide , and (b) nanoparticles of a catalyst selected from the group consisting of platinum , palladium , and rhodium; wherein the microparticles of chemochromic metal oxide material have a range of sizes less than 200 microns in diameter; wherein the metal oxide macroparticles are coated with catalyst nanoparticles having a ...

COMPONENT MEASURING DEVICE

A component measuring device includes a calibration member that is slidably disposed in an insertion hole of a chip attachment unit and a biasing member that biases the calibration member toward an insertion port. The calibration member is held by the biasing member at a position where the calibration member blocks the introduction port and a lead-out port and where light from a light emitter is applied to the calibration member when a measuring chip is not inserted in the insertion hole, and slides to a side opposite to the insertion port along with insertion of the measuring chip into the insertion hole so that light from the light emitter is applied to the measuring chip. 1. A component measuring device that measures a predetermined component in a body fluid taken into a measuring chip , the component measuring device comprising:a chip attachment unit including an insertion hole into which the measuring chip is inserted;a light emitter that applies light to the measuring chip through an introduction port open on a wall surface constituting the insertion hole;a light receiver that receives light from the measuring chip guided through a lead-out port open on the wall surface constituting the insertion hole;a calibration member slidably disposed in the insertion hole along an insertion direction of the measuring chip; andbiasing member for biasing the calibration member toward an insertion port of the insertion hole, whereinthe calibration member is held by the biasing member at a position where the calibration member blocks the introduction port and the lead-out port and where light from the light emitter is applied to the calibration member when the measuring chip is not inserted in the insertion hole, and slides to a side opposite to the insertion port along with insertion of the measuring chip into the insertion hole so that light from the light emitter is applied to the measuring chip.2. The component measuring device according to claim 1 , further comprising a ...

TEST STRIP INDICATOR DETERMINING SYSTEM, TERMINAL DEVICE, AND METHOD

PROBLEM To provide a determining system, terminal device, and determining method that can automatically determine various types of indicators. RESOLUTION A determining system determines a status of an indicator where optical properties change under a specific environment, and is provided with: an image acquiring part that acquires an image containing the indicator; a type information acquiring part that acquires information indicating a type of the indicator; a color information acquiring part that acquires color information before change and after change of the indicator corresponding to the type; an extracting part that extracts a first region configured from a color after change of the indicator in the image based on the color information; and the status determining part that determines a shape of the first region extracted by the extracting part and status of the indicator based on a determination status corresponding to the type. 1. A determining system for determining a status of an indicator that changes optical properties based on a specific environment , the determining system comprising:an image acquiring part that acquires an image including an indicator;a type information acquiring part that acquires information showing type of the indicator;a color information acquiring part that acquires color information before and after change of the indicator that corresponds to the type;an extracting part that extracts a first region of the image that contains the color after change of the indicator, based on the color information; anda status determining part that determines status of the indicator based on a determining status that corresponds to the type and the shape of the first region that was extracted by the extracting part.2. The determining system according to claim 1 , wherein the first region has a shape that extends in a longitudinal direction claim 1 , and wherein the status determining part determines the status of the indicator based on the aspect ...

TRACE ELEMENTS DETECTION TEST PAPER AND PREPARATION METHOD THEREOF

The disclosure provides a trace element detection test, whose items are spliced by different variety of strips, including: routine urine test paper, test paper, calcium iron and zinc test, each block corresponding to each color recognition test items test results of paper. The trace element test paper of the invention can conveniently and comprehensively judge the urine routine items in children's urine and the content of trace elements such as calcium, iron and zinc whether normal or not. The preparation method of the calcium detection test paper is simple and effective, and has the advantages of low one-time use, convenient use and fast and accurate detection result. 1. A trace elements detection test paper composite , comprising:a urine test paper;a calcium detection test paper;an iron detection test paper; anda zinc detection test paper,wherein the urine test paper, the calcium detection test paper, the iron detection test paper, and the zinc detection test paper provide result indications according to different color indication schemes.2. The trace elements detection test paper composite of claim 1 , wherein each of the urine test paper claim 1 , the calcium detection test paper claim 1 , the iron detection test paper claim 1 , and the zinc detection test paper has a length of between 5 mm and 30 mm claim 1 , a width of between 5 mm and 20 mm claim 1 , and a thickness of between 1 mm and 5 mm.3. The trace elements detection test paper composite of claim 2 , wherein the urine test paper detects at least a weight of urine detected in the diaper claim 2 , a PH value of the urine claim 2 , leukocytes content in the urine claim 2 , nitrite content in the urine claim 2 , protein content in the urine claim 2 , glucose content in the urine claim 2 , ketone bodies content in the urine claim 2 , urobilinogen content in the urine claim 2 , bilirubin content in the urine claim 2 , erythrocyte content in the urine claim 2 , and vitamin C content in the urine.4. The trace ...

WEARABLE WITH TEST STRIPS AND OPTICAL READER FOR SKIN

The present invention generally relates to a wearable electronic device that collects information about test sample using an optical sensor. The wearable device photographs and analyzes one or more organic samples placed on one or more immunoassay regions of a test strip in order to reveal information about the sample. The wearable electronic device may also sequentially photograph a plurality of individual organic samples applied to different immunoassay regions of a test strip. 1. A wearable sample analysis device , the apparatus comprising:a chamber comprising at least a portion of a rotatable test strip, wherein the test strip comprises a plurality of spaced immunoassay regions;an opening in the wearable device, wherein the opening receives a sample from the skin of a person, and wherein the sample accesses one of the plurality of spaced immunoassay regions;a rotatable carousel, where in the rotatable carousel moves the rotatable test strip from a first position to a second position, wherein in each of said first and second positions a respective one of the plurality of immunoassay regions is aligned with said opening to receive a sample;an optical reader, wherein the optical reader acquires an optical image of a first immunoassay region of the plurality of immunoassay regions of the test strip when the test strip is in the first position, and further acquires an optical image of a second immunoassay region of the plurality of immunoassay regions of the test strip when the test strip is in the second position; anda processor in communication with the optical reader, wherein the processor analyzes at least one of the first and second optical images;wherein the test strip is removed from the chamber after each of the plurality of immunoassay regions have received a sample via the opening.2. (canceled)3. The wearable sample analysis device of claim 1 , wherein the processor identifies at least one color characteristic of the optical image of the first immunoassay ...

Arrays of integrated analytical devices

Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions.

METHODS AND SYSTEM FOR PERFORMANCE ASSESSMENT OF CLEANING OPERATIONS

The present disclosure relates to a process and a system for assessing the performance of cleaning operations by utilizing an automatic read out routine for test strips subjected to a cleaning operation. Furthermore, the present disclosure relates to a computer program product capable of performing the process. 1. An imaging box for use in an image capture procedure for the performance assessment of cleaning operations , comprising:a housing defined by a front surface and a back surface and forming an interior cavity when the housing is placed on a substantially flat surface, the front surface having a receptacle configured to receive a mobile device,the front surface further including at least one camera aperture configured to correspond to the position of a camera lens of the mobile device when the mobile device is received in the receptacle,the back surface including a test strip slot configured to receive and hold a chemical test strip comprising a carrier and an indicator means in a substantially flat position,the back surface further including a test strip aperture configured to correspond to the position of a chemical test strip when received into the test strip slot, such that an image of the chemical test strip may be captured by the camera of the mobile device when the chemical test strip is inserted into the test strip slot such that the indicator means is facing the interior cavity of the housing.2. The imaging box of claim 1 , wherein the front surface of the housing further includes a flash aperture configured to correspond to the position of a light emitting flash of the mobile device when the mobile device is received in the receptacle.3. The imaging box of further including at least one diffusing rib positioned within the interior cavity of the housing to diffuse light emitted from the flash of the mobile device.4. The imaging box of further comprising a light source positioned within the interior cavity of the housing.5. The imaging box of further ...

TEST STRIP METER WITH A MECHANISM FOR PUSHING THE TEST STRIP AGAINST AN OPTICAL READER

The present invention relates to a system, method, and meter for determining the concentration of an analyte in a fluid sample provided on a test strip. The meter () may include a body (), an optical reader (), and a test strip holder (). The body () has first () and second ends () and defines a longitudinal axis y extending between the first and second ends (). The optical reader () may be coupled to the body () and adapted to analyze the analyte on the test strip. The test strip holder () may be coupled to the body () and include first and second arms (). One of the optical reader () or the test strip holder () may be movable along the longitudinal axis of the body between a first position, in which the first and second arms () of the test strip holder () overlie the optical reader (), and a second position, in which the optical reader () extends beyond the first and second arms () of the test strip holder (). Such configuration allows to push the test strip against the optical reader (). Pins () are also disposed on the test strip holder () to grasp the extremities of the test strip and stretch said strip against the optical reader (). 1. A meter for determining the concentration of an analyte in a fluid sample provided on a test strip , the meter comprising:a body having first and second ends, the body defining a longitudinal axis extending between the first and second ends;a read-head coupled to the body and adapted to analyze the analyte on the test strip; anda test strip holder coupled to the body, the test strip holder having first and second arms,wherein at least one of the read-head or the test strip holder is movable along the longitudinal axis of the body between a first position, in which the first and second arms of the test strip holder overlie the read-head, and a second position, in which the read-head extends beyond the first and second arms of the test strip holder.2. The meter of claim 1 , wherein the read-head is tapered.3. The meter of claim 2 ...

PORTABLE ELECTRONIC ASSAY DEVICE, PORTABLE ASSAY DEVICE AND KIT THEREOF

The present invention is related to a portable electronic assay device, a portable assay device and a kit thereof. The portable electronic assay device is used for determining a result of an assay performed using a test strip comprises a casing, an optical module, a light detector, and a processor. The casing comprises a transmissive part. The optical module emits a detecting light signal and display light signal. The detecting light signal is illuminated to the test strip and the display light signal is illuminated to the transmissive part. The light detector detects light from the test strip so as to obtain a detecting signal. The processor receives the detecting signal compared with a default value so as to obtain an assay result. The assay result is displayed on the transmissive part. Therefore, it provides simple structure of the assay device for displaying the assay result rapidly and correctly. 1. A portable electronic assay device used for determining an assay result of an assay adapted by using a test strip , the device comprising:a casing comprising a transmissive part and a containing space, the containing space used for containing the test strip;an optical module illuminating a detecting light signal and a display light signal, wherein the detecting light signal is illuminated to the test strip, and the display light signal is illuminated to the transmissive part;a light detector detected the light from the test strip to obtain a detected signal; anda processor electrically connected to the optical module and the light detector to receive the detected signal, and comparing the detected signal with a default value to obtain an assay result, and illuminating the display light signal to the transmissive part based on the assay result.2. The device as claimed in claim 1 , wherein the casing further comprises an opening and the device further comprises a shading positioned at the opening claim 1 , and the transmissive part is formed in the shading.3. The ...

VENDOR EXCLUSIVITY SECURITY FEATURE FOR PAPER-BASED DIAGNOSTIC SOLUTION

Disclosed herein is a paper based diagnostic device including a portable biomedical diagnostic device comprising, paper, wax, and reagents. The biomedical diagnostic device can analyze biochemical assays in test fluids such as blood, urine, and saliva. Diagnostic devices can include one or more of tracking information, personal identification information, security information, color calibration information, and environmental indicators. The security information can further include keys or codes identifying one or more unique characteristics. One aspect of the security information ensures that only predeterminable vendors are able to determine the results of a test from the diagnostic devices. 1. A paper-based sensor method comprising:applying a test sample of a substance to a paper-based sensor, the paper-based sensor reacting to the test sample to generate one or more color indicators;capturing an image of the paper-based sensor after the test sample is applied to the paper-based sensor;performing colorimetric image processing of the captured image of the paper-based sensor to determine one or more colorimetric properties associated with the paper-based sensor, the colorimetric properties indicating one or more attributes associated with the test sample;wherein the paper-based sensor includes one or more of tracking information, personal identification information, security information, color calibration information, and environmental indicators; and,wherein said security information includes a key to decode at least one unique characteristic.2. The paper-based sensor method according to claim 1 , comprising:communicating the one or more attributes associated with the test sample to one or more of a patient and a caregiver.3. The paper-based sensor method according to claim 1 , comprising:performing predictive analytics.4. The paper-based sensor method according to claim 1 , wherein the unique characteristic includes one or more of a unique identifier claim 1 , ...

FLUID TEST DEVICE AND MODULE

Embodiments for local and safe testing of injection fluids by drawing a sample of injection fluid into a local test chamber while drawing fluid to be tested into a syringe assembly and testing the sample of the injection fluid are disclosed. A fluid test device can include a syringe assembly, a plunger assembly, and a test module. The test module can determine information about fluid in a syringe assembly when the fluid enters a test chamber in the test module. Fluid may enter the test chamber through a one-way valve while a plunger in the plunger assembly is moved in a suction stroke to draw fluid into an interior of the syringe assembly. Fluid may not enter or be expelled from the test chamber when the plunger does not move or is moved in a compression stroke to expel fluid from the syringe assembly. 1. A fluid test device comprising:a syringe comprising a barrel and a plunger that is movable in the barrel, the syringe being configured to draw a fluid into the barrel when the plunger is moving from a plunger closed position to a plunger open position and being configured to expel fluid from the barrel when the plunger is moving from the plunger open position to the plunger closed position;a test module connectible to the syringe, the test module including a test chamber configured to receive a sample of the fluid from the syringe as the plunger is moving from the plunger closed position to the plunger open position; anda test medium contained in the test chamber, wherein when the sample is received by the test module and exposed to the test medium, the test medium is configured to indicate information about the sample.2. The fluid test device of claim 1 , wherein the test medium comprises a test strip configured to detect the presence or concentration of a substance in the sample.3. The fluid test device of claim 2 , wherein at least a portion of the test strip is configured to change to a color indicative of the presence or concentration of the substance in the ...

EXTERNAL LOAD TRANSPORT ASSEMBLY FOR AN AERIAL VEHICLE AND USE OF THE SAME FOR THE CONSTRUCTION AND MAINTENANCE OF POWER LINES

There is provided an external load transport assembly for an aerial vehicle. The assembly includes a load suspension line having a first end connectable to the aerial vehicle and a second end connectable to an external load. The assembly includes a relative humidity indicator positioned to monitor moisture content of the load suspension line. The assembly includes an at least partially transparent coating encasing the load suspension line and the relative humidity indicator. 1. An external load transport assembly for an aerial vehicle , the assembly comprising:a load suspension line having a first end connectable to the aerial vehicle and a second end connectable to an external load;a water-content or relative humidity indicator positioned to monitor moisture content of the load suspension line; andan at least partially transparent coating encasing the load suspension line and the indicator.2. The assembly of wherein the indicator is protected by and viewable through the at least partially transparent coating.3. The assembly of wherein the indicator is configured to provide a visual indication of changes in dielectric properties of the load suspension line.4. The assembly of wherein the coating is at least one of: a clear said coating; a polymer said coating; a polyurethane said coating; and a clear polyurethane said coating.5. The assembly of wherein the load suspension line comprises at least one of: a structural core made of a non-conducting material; synthetic rope; rope made of non-metal fibers; and high modulus polyethylene fiber (HMPE) rope.6. The assembly of wherein the load suspension line comprises a rope made of non-metal fibers and wherein the at least partially transparent coating encases the indicator adjacent to the fibers to provide a visual signal of moisture properties thereof over a length of the load suspension line.7. The assembly of wherein the load suspension line includes rope made of fibers claim 1 , and wherein the at least partially ...

Bio-fluid analysis and reporting system and method

A system and method for analyzing bio-fluid constituents and properties in a bio-fluid sample, wherein the system comprises a bio-fluid collection apparatus, a bio-fluid testing/analysis apparatus, and a reporting apparatus.

PHOTONIC CRYSTAL LASER AND STRAIN MEASURING DEVICE

A photonic crystal laser and a strain measuring device are provided. The photonic crystal laser includes a disk-shaped photonic crystal structure two-dimensionally disposed in a matrix on a disposition plane and a flexible substrate disposed to support the photonic crystal structure and to cover at least a side surface of the photonic crystal structure. 1. A photonic crystal laser comprising:a disk-shaped photonic crystal structure two-dimensionally disposed in a matrix on a disposition plane; anda flexible substrate disposed to support the photonic crystal structure and to cover at least a side surface of the photonic crystal structure.2. The photonic crystal laser as set forth in claim 1 , wherein an arrangement period of the photonic crystal structure is between 550 and 700 nm claim 1 , andthe photonic crystal structure oscillates in a E-point band-edge mode.3. The photonic crystal laser as set forth in claim 2 , wherein a laser gain medium of the photonic crystal structure is InGaAsP spontaneously emitted at an infrared area or AlGaAs spontaneously emitted around 650 nm.4. The photonic crystal laser as set forth in claim 3 , wherein the photonic crystal structure includes an InGaAsP lower cladding layer claim 3 , a quantum well InGaAsP active layer claim 3 , and an InGaAsP upper cladding layer that are sequentially stacked.5. The photonic crystal laser as set forth in claim 1 , wherein the flexible substrate includes polydimethylsiloxane (PDMS) claim 1 , polyimide or polyethylene terephthalate (PET).6. The photonic crystal laser as set forth in claim 1 , further comprising:pressure applying means for applying a strain to the flexible substrate.7. A method for fabricating a photonic crystal layer claim 1 , comprising:forming an etch-stop layer on a substrate;forming a buffer layer on the etch-stop layer;forming a photonic crystal active layer on the buffer layer;coating a resist on the photonic crystal active layer and patterning the coated resist to form a ...

Method for Detection of Legionella Bacteria Employing Purified Antigen-Specific Antibodies

The present invention involves extracting from Legionella bacteria, particularly L. pneumophila bacteria, an essentially protein-free O-polysaccharide or carbohydrate antigen, coupling this antigen to an activated chromatographic column through a protein space molecule which is first conjugated to the antigen, utilizing the column thus prepared for the affinity purification of raw polyvalent antibodies to the same Legionella bacterium from which the O-polysaccharide or carbohydrate antigen was separated—thereby obtaining antigen-specific antibodies which are useful for the rapid detection of the corresponding Legionella bacterium or its antibody in human bodily fluids such as urine, sputum, blood and the like or in environmental samples suspected of harboring the Legionella bacterium.

FECES SAMPLING AND DETECTING DEVICE AND METHOD FOR DETECTING FECES BASED ON THE DEVICE

The present invention provides a feces sampling and detecting device and a method for detecting feces based on the feces sampling and detecting device. The device includes a detector, a casse with detecting strips provided in the detector, a collector accommodated in the detector detachably, a feces sampler for sealing the collector detachably, and at least one puncturing part arranged at a bottom of the detector facing one side of the collector. The feces sampling and detecting device can detect collected feces quickly, thereby avoiding feces sample from nature changing in an interval period, and preventing liquid in the collector from entering the detector to influence safety of the device of the present invention. 1. A feces sampling and detecting device , wherein comprising: a detector , detecting strips provided in the detector , a collector accommodated in the detector detachably , a feces sampler for sealing the collector detachably; and at least one puncturing part arranged at a bottom of the detector facing the collector.2. The device according to claim 1 , wherein both the detector and the collector comprise a side wall and a bottom combined with the side wall claim 1 , and both bottom area and height of the collector are less than that of the detector; preferably claim 1 , the sum of heights of the feces sampler combined with collector and height of the puncturing part is less than or equal to the height of the detector; more preferably claim 1 , shapes of the collector and the detector are the same.3. The device according to claim 2 , wherein the bottom of the collector is made of a material which is easy to be punctured; preferably claim 2 , the bottom of the collector is made of aluminium foil.4. The device according to or claim 2 , wherein there are two puncturing parts which are respectively arranged at two sides of a relatively long symmetry axis on a plane where the bottom of the detector and the bottom of the collector are superposed;preferably, ...

SYSTEM AND METHODS FOR REMOTE ASSESSMENT OF A SAMPLE ASSAY FOR DISEASE DIAGNOSTICS

A method for performing a lateral flow assay is provided. The method includes inserting a sample cartridge () in a dark chamber () and activating a light emitter () in the dark chamber (). The method includes focusing an optical coupling mechanism () in an image-capturing device () to optimize an image of a sensitive area () in the sample cartridge () and capturing, with an image capturing device (), an image of a sensitive area () in the sample cartridge () after a selected period of time. The method also includes providing the image of the sensitive area () to a processor, wherein the processor comprises an image-capturing application (). A system and a computer-implemented method to perform at least partially the above method are also provided. 1. A method , comprising:inserting a sample cartridge in a dark chamber;activating a light emitter in the dark chamber;positioning an optical coupling mechanism in an image-capturing device with respect to the sample cartridge to optimize quality of an image of a sensitive area in the sample cartridge;capturing, with the image capturing device, an image of a sensitive area in the sample cartridge after a selected period of time;providing the image of the sensitive area to a processor, wherein the processor comprises an image-capturing application; andintegrating, with the image-capturing application, multiple pixel counts separately for different color pixels in a sensor array of the image-capturing device.2. The method of claim 1 , further comprising interacting a user sample containing a biological residual from a user with a reagent claim 1 , in the sample cartridge.3. The method of claim 1 , wherein activating the light emitter in the dark chamber comprises activating a fluorescence excitation source.4. The method of claim 1 , further comprising capturing a second image of the sensitive area after a second period of time claim 1 , and determining the selected period of time and the second period of time based on a ...

PAPER SENSING AND ANALYTIC SERVICE WORKFLOW METHODS AND SYSTEMS

This disclosure provides a workflow method and system associated with a paper-based sensor. Specifically, provided is a paper-based sensor workflow including printing of customized security sensing information and bio-reagents to produce a paper-based sensor, applying a test material, such as, but not limited to, blood, to the paper-based sensor, capturing an image of the paper-based sensor and performing a colorimetric process; and performing one or more analytics to produce results associated with the test material 1. A paper-based sensor method comprising:applying a test sample of a substance to a paper-based sensor, the paper-based sensor reacting to the test sample to generate one or more color indicators;capturing an image of the paper-based sensor after the test sample is applied to the paper-based sensor;performing colorimetric image processing of the captured image of the paper-based sensor to determine one or more colorimetric properties associated with the paper-based sensor, the colorimetric properties indicating one or more attributes associated with the test sample; and,wherein the paper-based sensor includes two or more of tracking information, personal identification information, security information, color calibration information, and environmental indicators.2. The paper-based sensor method according to claim 1 , comprising:communicating the one or more attributes associated with the test sample to a user.3. The paper-based sensor method according to claim 2 , comprising: performing predictive analytics for monitoring the user's health conditions.4. The paper-based sensor method according to claim 1 , wherein the paper-based sensor includes tracking information claim 1 , environmental indicators and security information claim 1 , and the method validates the captured image of the paper-based sensor based on one or more of the tracking information claim 1 , environmental indicators and security information.5. The paper-based sensor method according ...

PORTABLE SPECTROMETER FOR CHEMICAL SENSING

Techniques are disclosed for a chemical sensor architecture based on a fabric-based spectrometer. An example apparatus implementing the techniques includes a portable spectrometer device including a first fabric layer and a second fabric layer coupled to the first fabric layer to form a pouch. The second fabric layer includes a fiber fabric spectrometer substrate comprising a fiber material including one or more electronic devices, wherein the pouch is configured to receive a colorimetric substrate and the fiber fabric spectrometer substrate is configured to measure reflectance of a colorimetric substrate disposed in the pouch. 1. A portable spectrometer device comprising:a first fabric layer; anda second fabric layer coupled to the first fabric layer to form a pouch, the second fabric layer comprising a fiber fabric spectrometer substrate comprising a fiber material including one or more electronic devices, wherein the pouch is configured to receive a colorimetric substrate and the fiber fabric spectrometer substrate is configured to measure reflectance of a colorimetric substrate disposed in the pouch.2. The portable spectrometer device of claim 1 , further comprising at least one colorimetric substrate disposed in the pouch.3. The portable spectrometer device of claim 2 , wherein a surface of the colorimetric substrate is disposed over a surface of the fiber fabric spectrometer substrate.4. The portable spectrometer device of claim 3 , further comprising a control component coupled to the fiber fabric spectrometer substrate and configured to control at least one of the one or more electronic devices of the fiber fabric spectrometer substrate to measure reflectance of the colorimetric substrate.5. The portable spectrometer device of claim 3 , wherein the at least one colorimetric substrate comprises at least one colorimetric sensor element claim 3 , the at least one colorimetric sensor element configured to undergo an electronic structure change upon reaction with ...

OPTOCHEMICAL SENSOR, SENSOR CAP, USE OF THE OPTOCHEMICAL SENSOR, AND METHOD FOR PRODUCING AN ANALYTE-SENSITIVE LAYER OF AN OPTOCHEMICAL SENSOR

An optochemical sensor for determining a pH of a measured medium includes a sensor membrane having an analyte-sensitive layer. The sensor membrane has a first luminophoric dye in the form of an indicator dye and a second luminophoric dye in the form or a reference dye. At least one of the two aforementioned dyes is contained in the analyte-sensitive layer, and one of the two aforementioned dyes has an inorganic framework structure. At least one inorganic or organic receptor group, which is protolyzable, is bonded to the framework structure. 1. An optochemical sensor for determining a pH of a measured medium , comprising:a sensor membrane having an analyte-sensitive layer, wherein the sensor membrane has a first luminophoric dye in the form of an indicator dye and a second luminophoric dye in the form of a reference dye, wherein at least one of the first luminophoric dye and the second luminophoric dye is contained in the analyte-sensitive layer, andwherein one of the of the first luminophoric dye and the second luminophoric dye has an inorganic framework structure, wherein at least one inorganic or organic receptor group which is protolyzable is bonded to the framework structure.2. The optochemical sensor of claim 1 , wherein the signal detection is triggered by a PET effect claim 1 , wherein the indicator dye has a decay time of between 5 and 900 ns and the reference dye has a decay time of more than 1 μs.3. The optochemical sensor of claim 1 , wherein the receptor group is formed as an amine group claim 1 , phenol group claim 1 , or carboxylic acid group.4. The optochemical sensor of claim 1 , wherein the sensor membrane comprises a substrate.5. The optochemical sensor of claim 1 , wherein the framework structure comprises a semiconductor material.6. The optochemical sensor of claim 1 , wherein the framework structure comprises indium claim 1 , zinc claim 1 , copper claim 1 , silver claim 1 , or gold.7. The optochemical sensor of claim 1 , wherein the framework ...

FERTILITY AND PREGNANCY MONITORING DEVICE AND METHOD

A pregnancy monitoring device and method improve detection in the first trimester of the occurrence of ectopic pregnancy and the occurrence of multiple foetuses. The device includes a sample absorbing member and an analyser to analyse a plurality of sequential a biological liquid samples and computing means to determine an ovulation date and deviations in the measured quantity of hCG from predetermined values which are indicators of ectopic pregnancy or multiple pregnancy. The device and method enables early detection of ectopic pregnancy or multiple pregnancy. 1. A fertility and pregnancy monitoring device , comprising:a sample holder configured to accept a sample absorbing member that has absorbed a portion of a biological liquid sample;an analyzer; anda display means;wherein the analyzer is configured to analyze the sample absorbing member in the sample holder by measuring a parameter indicative of a quantity of luteinizing hormone (LH) present in the biological liquid sample and by measuring a parameter indicative of a quantity of a human chorionic gonadotropin hormone (hCG) in the biological liquid sample, the analyzer being further provided with electronic computing means; andwherein the computing means is configured to calculate and record a plurality of measurements from a plurality of sequential sample absorbing members and to identify a predetermined increase in the measured quantity of LH in the biological liquid sample to determine an ovulation date while also identifying and recording the measured quantity of hCG in the biological liquid sample, where deviations in the measured quantity of hCG from predetermined values are determined to be indicators abnormal pregnancy and wherein an indication of the health of the pregnancy is displayed on the display means.2. A fertility and pregnancy monitoring device according to claim 1 , wherein the analyzer is configured to analyze a number of measurable parameters such as colour claim 1 , pH claim 1 , ...

ROBUST COLORIMETRIC PROCESSING METHOD FOR PAPER BASED SENSORS

The present disclosure proposes a colorimetric method that couples sensor design with image processing to enable automated evaluation of test results obtained by paper-based sensors. The proposed method can match ink color and dye used in colorimetric reaction in terms of their absorption in spectral range (e.g., red, green, blue). A near-zero absorption channel can then be used to normalize absorption channels and construct a composite image. 1. A colorimetric processing method for paper based sensors , comprising:using a camera and taking a picture of a colorimetric paper sensor for colorimetric reactions;identifying the type of paper sensor by image processing;identifying one color channel in which both a dye and reference color have near zero absorption and wherein the color channels in which both the dye and the reference color have absorption;identifying the known absorption ratio between the dye and the reference color in each color channel;separating each test area in the channel from the non-test areas;normalizing each absorption channel by the near zero absorption channel to remove spatial variation;calibrating the test area reading with the reference color and a substrate white in the composite image; and,reporting the concentration of a test substance analyte based on the calibrated reading in each test area.2. The method according to claim 1 , further comprising:locating the test areas in the near zero absorption channels by image processing.3. The method according to claim 2 , further comprising:using an additional camera and taking another picture of the colorimetric paper sensor to construct a composite image from one or more absorption channels.4. The method according to claim 1 , wherein the colorimetric paper sensor is a biomedical paper sensor for determining a concentration of biological materials in fluids comprising:a plurality of axial symmetric test zones;wherein the test zones radiate outward from a central point;each of the axial symmetric ...

Reference cassette for fluorescence immunoassay diagnostic device

Provided in the present invention is a reference cassette for a fluorescence immunoassay diagnostic device, the cassette having, arranged in a case, fluorescent glass capable of maintaining fluorescence characteristics to be constant without causing degeneration, so as to accurately provide reference measurement information about the fluorescence detection amount during testing of the measurement accuracy of the fluorescence detection of the immunoassay diagnostic device, so that testing accuracy can improve, preventing decrease in measurement accuracy and being semi-permanently usable since the denaturation or deterioration of the fluorescent glass does not occur even if the cassette is used continuously, and providing a mask having a slit so as to limit the area of the fluorescent glass to be externally exposed to a specific area, thereby generating the type of fluorescence that is the same as that of a reaction area of a sample strip to be actually used, and thus more accurate reference measurement information can be provided.

TECHNIQUES FOR PERFORMING OPTICAL AND ELECTROCHEMICAL ASSAYS WITH UNIVERSAL CIRCUITRY

This present invention relates generally to devices, systems, and methods for performing optical and electrochemical assays and, more particularly, to devices and systems having universal channel circuitry configured to perform optical and electrochemical assays, and methods of performing the optical and electrochemical assays using the universal channel circuitry. The universal channel circuitry is circuitry that has electronic switching capabilities such that any contact pin, and thus any sensor contact pad in a testing device, can be connected to one or more channels capable of taking on one or more measurement modes or configurations (e.g., an amperometric measurement mode or a current drive mode). 1. A system comprising:one or more processors; and receiving an operating state signal from a test cartridge indicative of a type of test cartridge inserted into an analyzer;', 'determining, based on the type of test cartridge, that the test cartridge has a first contact connected to a light emitter and a second contact connected to a light detector;', 'assigning a first channel to the light emitter via the first contact and a corresponding first pin;', 'assigning a second channel to the light detector via the second contact and a corresponding second pin;', 'switching circuitry of the first channel to a current driver mode;', 'switching circuitry of the second channel to a current measurement mode;', 'applying, using the first channel, a drive current to the light emitter;', 'converting, using the second channel, an output signal received from the light detector to an analyte signal proportional to an amount light detected by the light detector; and', 'determining a qualitative, semi-quantitative, or quantitative value proportional to an amount of analyte in a biological sample in the test cartridge based on the analyte signal., 'memory coupled to the one or more processors, the memory encoded with a set of instructions configured to perform a process comprising2. ...

ARRAYS OF INTEGRATED ANALYTICAL DEVICES

Arrays of integrated analytical devices and their methods for production are provided. The arrays are useful in the analysis of highly multiplexed optical reactions in large numbers at high densities, including biochemical reactions, such as nucleic acid sequencing reactions. The devices allow the highly sensitive discrimination of optical signals using features such as spectra, amplitude, and time resolution, or combinations thereof. The devices include an integrated diffractive beam shaping element that provides for the spatial separation of light emitted from the optical reactions. 143-. (canceled)44. An array of integrated analytical devices , each device comprising:a nanoscale emission volume;a detector layer optically coupled to the nanoscale emission volume;a diffractive beam shaping element disposed between the nanoscale emission volume and the detector layer; anda color filtration layer disposed between the diffractive beam shaping element and the detector layer, wherein the color filtration layer comprises 2 to 9 color filtration elements, each color filtration element specific for a range of light wavelengths;wherein light is emitted from the nanoscale emission volume by a plurality of emitters within the emission volume;wherein the detector layer comprises a plurality of sensing regions, and wherein the sensing regions are optically coupled to the color filtration elements; andwherein the diffractive beam shaping element spatially separates the light emitted from the nanoscale emission volume into a plurality of beams and directs the spatially-separated light beams through the color filtration elements and onto the sensing regions.45. The array of wherein the number of color filtration elements claim 44 , sensing regions claim 44 , and separated beams per integrated analytical device is 2.46. The array of wherein the plurality of emitters is 4 emitters.47. The array of claim 44 , wherein the diffractive beam shaping element is a hybrid lens.48. The array ...

TEST SYSTEM

Provided is a test system operable with a simplified structure. A test system includes a test device and a test device each of which transports and tests a sample. The test device includes a master control unit, which performs assignment of samples to the test device and the test device, and control of a transport operation of the sample assigned to the test device. The test device includes a slave control unit, which controls a transport operation of the sample assigned to the test device by the master control unit. 1. A test system comprising:a first test device that transports and tests a sample; anda second test device located adjacent to the first test device that transports and tests a sample, whereinthe first test device includes a master control unit that performs assignment of samples to the first test device and the second test device, and controls of a transport operation of the sample assigned to the first test device, andthe second test device includes a slave control unit that controls a transport operation of the sample assigned to the second test device by the master control unit.2. The test system according to claim 1 , whereinthe first test device comprises:a first supply transport unit that supplies the sample to a first loading position to load the sample; anda first bypass transport unit that transports the sample to the second test device while causing the sample to bypass the first loading position, andthe second test device comprises a second supply transport unit that supplies the sample, accepted via the first bypass transport unit, to a second loading position to load the sample.3. The test system according to claim 2 , whereinwhen the master control unit assigns a sample to the first test device, the master control unit controls the first supply transport unit in such a way that the sample is supplied to the first loading position, andwhen the master control unit assigns a sample to the second test device, the master control unit controls ...

TEST STRIP ANALYSER AND ANALYSING METHOD USING THE SAME

A test strip analyser is provided. The test strip analyser includes a frame, a test control module and an optical system. The test control module is disposed in the frame and includes a test strip carrier of a plurality of test strip carriers and a sample container of a plurality of sample containers. The test strip carrier is disposed on the frame and adapted to hold a test strip. The sample container is adapted to contain a sample. The optical system is disposed above the frame and the test control module and includes a light sensor and controller. The light sensor is configured to capture an image of the test strip. The controller is connected to the light sensor to control the light sensor, and the light sensor feedbacks the image to the controller. In addition, an analysing method using the same is also provided. 1. A test strip analyser , comprising:a frame; a test strip carrier, disposed on the frame and adapted to hold a test strip; and', 'a sample container, adapted to contain a sample; and, 'a test control module disposed in the frame, comprising a light sensor, configured to capture an image of the test strip; and', 'a controller, connected to the light sensor to control the light sensor, and the light sensor feedbacks the image to the controller., 'an optical system, configured above the frame and the test control module, the optical system comprising2. The test strip analyser as claimed in claim 1 , wherein the frame comprises a movable support claim 1 , wherein the movable support is slidably disposed on the frame to move in a first direction claim 1 , and supports the test strip carrier.3. The test strip analyser as claimed in claim 2 , wherein the test strip carrier comprises a carrying portion for holding the test strip and a supporting portion supported by the movable support claim 2 , and the carrying portion and the supporting portion are offset from each other in the first direction.4. The test strip analyser as claimed in claim 1 , further ...

SYSTEMS AND METHODS FOR REAGENTLESS TEST STRIPS

A system for detecting an analyte with a reagentless dry test strip includes a collector for collecting a blood sample from a user. The system additionally includes a mixer for receiving the collector and mixing the blood sample. The system additionally includes reagents, located in the mixer, for mixing with the blood sample. The system additionally includes a dry test strip for receiving the blood sample mixed with the reagents. 1. A system for detecting an analyte with a reagentless dry test strip , comprising:a collector for collecting a blood sample from a user;a mixer, for receiving the collector and mixing the blood sample;reagents, located in the mixer, for mixing with the blood sample; anda dry test strip for receiving the blood sample mixed with the reagents.2. The system of claim 1 , further comprising:an optical meter, for detecting a color change in the test strip, the optical meter executing instructions stored in a fixed tangible medium in the optical meter, the instructions, when executed by the optical meter, causing the optical meter to detect an optical property of the test strip and reporting a level of an analyte in the blood sample based on the optical property.3. The system of claim 1 , wherein the collector includes a capillary tube.4. The system of claim 1 , wherein the mixer is shaped to seal with the collector when the collector is inserted into the mixer.5. The system of claim 1 , wherein the dry test strip includes a spreading layer.6. The system of claim 1 , wherein the dry test strip includes a first red blood cell separation layer.7. The system of claim 6 , wherein the dry test strip includes a second red blood cell separation layer.8. The system of claim 1 , wherein the dry test strip includes a reaction membrane.9. The system of claim 8 , wherein the reaction membrane does not include any reagents.10. The system of claim 9 , wherein the reagents provide for the testing of total cholesterol.11. The system of claim 10 , wherein the ...

STOOL SPECIMEN COLLECTING, SAMPLING AND DIAGNOSING MEANS AND METHODS THEREOF

System, means and methods are provided for collecting, sampling and testing stool samples. The present invention pertains to both mechanical and electrical, manual, semi-automatic, automatic means and methods for automatic sampling and homogenization or extraction of the stool samples, enabling their usability in various diagnosis and detection applications. 1. A device according to claim 82 , comprisinga motor actuating a rotatable axle reversibly connectable to said rotatable shaft, wherein said motor is an integral components within said housing or is a separable module connectable to said housing.281-. (canceled)82. A stool sample collecting device claim 82 , comprising:a. a housing including a chamber configured to be reversibly attachable to a toilet-bowl;b. a retractable swab wounded around a rotatable shaft, wherein said retractable swab is configured to be reversibly installed within said toilet having proximal and distal opposite ends; characterized by at least 2 configurations; an EXTENDED configuration, in which said distal end is configured to be in contact with said stool specimen; and, a RETRACTED configuration, in which said swab's distal end is retracted by rotation of said rotatable shaft into said chamber configuration.83. A device according to claim 82 , comprising at least one detector within said housing and in a fluid connection with said chamber claim 82 , wherein said at least one detector detects at least one marker in said stool specimen.84. A device according to claim 83 , wherein said at least one detector detects calprotectin in said stool specimen.85C. difficileHelicobacter pyloriCandidaChlamydia, Salmonella. A device according to claim 83 , wherein said at least one detector detects a marker selected from a group consisting of Lactofferin claim 83 , S100A12 claim 83 , Pancreatic Elastase Anti-Gliadin-IgA-Antibodies claim 83 , M2PK claim 83 , sDNA claim 83 , bacteria claim 83 , claim 83 , parasites claim 83 , claim 83 , leucocytes ...

CHEMICAL SEQUENCING AND CONTROL TO EXPAND AND ENHANCE DETECTION CAPABILITIES UTILIZING A COLORIMETRIC TEST

Embodiments of the present disclosure pertain to a colorimetric system for detecting a substance, the colorimetric system that includes a first chemical container adapted for releasing a first chemical; a second chemical container adapted for releasing a second chemical; a flow modulation sheet adjacent each chemical container; and an encapsulation covering the flow modulation sheet and each chemical container, where the encapsulation comprises a window defining a target area of the filter paper such that the target area is adapted for applying the substance; where the flow modulation sheet comprises a design adapted for automatically controlling a first flow of the first chemical and a second flow of the second chemical to the target area after simultaneously releasing the first and second chemicals; and where the design comprises a first void disposed in the flow modulation sheet. 1. A system for detecting a substance , the system comprising:a first container adapted for releasing a first chemical;a second container adapted for releasing a second chemical; and{'claim-text': ['a target area-adapted for applying the substance', 'a first portion comprising a first channel disposed between the first container and the target area, and', {'claim-text': 'wherein the flow modulation material is adapted for controlling a first flow of the first chemical and a second flow of the second chemical to the target area after releasing the first and second chemicals.', '#text': 'a second portion comprising a second channel disposed between the second container and the target area,'}], '#text': 'a flow modulation material comprising:'}2. The system for detecting a substance according to claim 1 , further comprising an encapsulation covering the flow modulation material and each container claim 1 , wherein the encapsulation comprises a window defining the target area.3. The system for detecting a substance according to claim 2 , wherein the encapsulation comprises a plastic.4. The ...

System and method for mobile device phosphor excitation and detection

The present disclosure is drawn to a method and system for the excitation, identification, and authentication of light emitting materials using a mobile device comprising at least one Vertical Cavity Surface Emitting Laser (VCSEL), for use in a variety of applications.

OPTICAL MEASUREMENT PROBE

The present disclosure relates to an optical measurement probe for the detection of measurement values correlating with a measurand of a measuring medium, including a probe housing having at least one immersion region structured to be immersed in the measuring medium, a radiation source arranged in the probe housing, a radiation receiver arranged in the probe housing, and an indicator chamber formed in the probe housing and sealed via a membrane arranged in the immersion region of the probe housing, wherein an indicator is contained in the indicator chamber, the indicator including an AIE-active substance dissolved in an indicator solution or in an indicator gel, which AIE-active substance is a substance formed from species, molecules, complexes or clusters whose luminescence efficiency is increased via formation of aggregates containing the species. 1. An optical measurement probe for detecting measurement values of a measurand of a measuring fluid , comprising:a probe housing having at least one immersion region structured to be immersed in the measuring fluid;a radiation source disposed in the probe housing;a radiation receiver disposed in the probe housing; andan indicator chamber defined in the probe housing and sealed via a membrane in the immersion region of the probe housing, wherein an indicator is contained in the indicator chamber, the indicator including an AIE-active substance dissolved in an indicator solution or in an indicator gel, which AIE-active substance is formed from species, including molecules, complexes or clusters, whose luminescence efficiency is increased via formation of aggregates containing the species.2. The optical measurement probe of claim 1 , wherein the measurand represents a concentration of an analyte in the measuring medium claim 1 , and wherein the membrane is permeable to the analyte.3. The optical measurement probe of claim 1 , wherein the membrane is impermeable to the species of the AIE-active substance of the indicator ...

Labelled Silica Nanoparticles for Immunochromatographic Reagent, Immunochromatographic Test Strip Using the Same, and Immunochromomatographic Fluorescence-Detecting System or Radiation-Detecting System

Labelled silica nanoparticles for immunochromatographic reagent, comprising silica nanoparticles containing a labelled substance. 1. An immunochromatographic test strip , comprisinga sample application member,a member impregnated with an immunochromatographic reagent comprising labelled silica nanoparticles which are both surface-modified with an analyte-recognizing substance and bonded with polyethylene glycol,a membrane having an antibody-immobilized region, andan absorption pad that are connected in series.2. The immunochromatographic test strip according to claim 1 , wherein two or more kinds of analytes are detected simultaneously claim 1 , based on the difference in hue of color formation or fluorescence wavelength in a single antibody-immobilized region.3. An immunochromatographic fluorescence-detecting system claim 1 , comprising:an immunochromatographic test strip, comprising1) a sample application member,2) a member impregnated with an immunochromatographic reagent comprising labeled silica nanoparticles, wherein said labeled silica nanoparticles are both surface-modified with an analyte-recognizing substance and bonded with polyethylene glycol,3) a membrane having an antibody-immobilized region, and4) an absorption pad,wherein 1)-4) are connected in series, andwherein the immunochromatographic reagent allows high-sensitivity detection by detection of fluorescence emitted from the silica nanoparticles containing the fluorescent substance, and wherein the wavelength of an excitation light source used for detection of the fluorescence emitted from the silica nanoparticles is 200 nm to 600 nm.4. The immunochromatographic fluorescence-detecting system according to claim 3 , further comprisinga filter eliminating the excitation light and transmitting only the fluorescence.5. The immunochromatographic fluorescence-detecting system according to claim 4 , further comprisinga photoelectron multiplier or a CCD detector detecting the fluorescence,wherein the system ...

Urine Test Device

There is provided a urine test device for detecting the presence of one or more compounds in urine. The test device comprises a base portion having a detection portion and a flexible attachment portion. The detection portion displays a change when the presence of any one of one or more compounds is detected in urine. The flexible attachment portion is movable from a first configuration to a second configuration in which the flexible attachment portion is extended to enable attachment to a toilet bowl. 1. A urine test device for detecting the presence of one or more compounds in urine , comprising:a base portion having a detection portion; anda flexible attachment portion; whereinsaid detection portion is configured to display a change when the presence of any one of said one or more compounds is detected in the urine; andsaid flexible attachment portion is movable from a first configuration to a second configuration in which said flexible attachment portion is extended to enable attachment to a toilet bowl.2. A urine test device according to claim 1 , wherein said flexible attachment portion is resiliently biased towards said base portion so as to be attachable to toilet bowls of differing dimensions.3. A urine test device according to claim 1 , wherein said base portion extends from said flexible attachment portion.4. A urine test device according to claim 3 , wherein said base portion extends from said flexible attachment portion at an angle of between 20 and 45 degrees.5. A urine test device according to claim 1 , further comprising a removable cover over said detection portion.6. A urine test device according to claim 5 , wherein said removable cover is fixed to said detection portion to provide an airtight seal.7. A urine test device according to claim 5 , wherein said removable cover is composed of a moisture-impervious solid material.8. A urine test device according to claim 1 , wherein said base portion is composed of a moisture-impervious material.9. A ...

ORTHOGONALLY REDUNDANT SENSOR SYSTEMS AND METHODS

A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body. 120-. (canceled)21. A glucose monitoring system comprising:{'claim-text': ['an optical glucose sensor including a light guide on a first substrate and having a proximal portion that is configured to be disposed externally to a body of a user and a distal portion configured for internal placement in the body of the user; and', 'a non-optical glucose sensor including at least one electrode on a second substrate and having a proximal portion that is configured to be disposed externally to the body of the user and a distal portion configured for internal placement in the body of the user, wherein the first substrate and the second substrate are integrated into an integrated flex circuit, and wherein the light guide is disposed in an interior of the integrated flex circuit and the at least one electrode is disposed on an external surface of the integrated flex circuit.'], '#text': 'an orthogonally redundant glucose sensor, comprising:'}22. The glucose ...

Monoliths

The present invention relates to a monolith for processing fluid samples, and methods of making and using the monolith. The monolith can contain certain monomers or combinations of monomers that can be polymerized to give a polymeric monolith that can efficiently self-wick fluid. The self-wicking polymeric monolith can be used as a convenient tool for point of care/on site diagnostics and analytics. The monolith is easily stored and transported, comparatively cost-efficient to make, permits good detection of analyte molecules and is readily functionalizable by impregnation of and/or covalently grafting additional chemical moieties to either the whole monolith or in zones.

Laminated Detector for Detection and Quantitative Determination of Formaldehyde

A multi-layered laminated test strip detector for formaldehyde is described which simplifies significantly the qualitative detection and quantitative determination of formaldehyde in aqueous solution or on the surface of wet solids. Layers of water soluble polymer are used to separate chemical reagents that otherwise will not be stable, and/or encapsulate the chemical reagents on bibulous material. Introducing the sample or wetting the detector through holes in a laminated encapsulating envelope permits the aqueous sample to dissolve the solid barrier when the sample is introduced and contact the reagents and the analyte, thereby forming color on the back side of the detector. 1. A sensitive reagent for the detection of aldehydes comprised of 4-amino-3-hydrazino-5-mercapto-1 ,2 ,4-triazole and a divalent , trivalent , or quadrivalent metal ion.2. The reagent of where the metal ion is selected from the group of bismuth claim 1 , aluminum claim 1 , chromium claim 1 , cadmium claim 1 , thallium claim 1 , copper claim 1 , cobalt claim 1 , nickel claim 1 , lead claim 1 , mercury claim 1 , lanthanum claim 1 , zinc claim 1 , calcium claim 1 , barium claim 1 , strontium claim 1 , titanium claim 1 , hafnium claim 1 , zirconium claim 1 , cerium claim 1 , vanadium claim 1 , iron claim 1 , manganese claim 1 , tin claim 1 , molybdenum and tungsten.3. A detector consisting of multiple layers of bibulous material containing reagents tailored to detect aldehyde comprising:A. an efficacy layer,B. an oxidizing layer.C. a reagent layer containing a hydrazine-based chromogene, and, a. keeps all the layers together,', 'b. facilitates the introduction of an aqueous sample into the detector from specific locations, entry ports, so that the liquid will wet the various layers in a specific pattern and order. and,', 'c. help keep the locations that color is formed in specific locations relative to the edges of the detector to facilitate visual and electronic color comparison and ...

PORTABLE ORGANIC MOLECULAR SENSING DEVICE AND RELATED SYSTEMS AND METHODS

A portable device for detecting an analyte associated with a target organic molecule in a liquid and/or solid substance. The device includes a test chamber, a probe, and a sensor. The test chamber contains a liquid volume of test solution including an analytical reagent selected to react with the analyte. The test chamber is sealed by a pierceable membrane wall. The probe is removably positionable to pierce the membrane wall to deposit a sample in the test chamber to form a test mixture with the test solution. The sensor is positioned to detect one or more characteristics of the test mixture in the test chamber indicative of a reaction between the analyte and the analytical reagent. 1. A portable device for detecting an analyte associated with a target organic molecule in a liquid and/or solid substance , the device comprising:a test chamber containing a liquid volume of test solution including an analytical reagent selected to react with the analyte, the test chamber sealed by a pierceable membrane wall;a probe removably positionable to pierce the membrane wall to deposit a sample in the test chamber to form a test mixture with the test solution; anda sensor positioned to detect one or more characteristics of the test mixture in the test chamber indicative of a reaction between the analyte and the analytical reagent.2. The portable device of claim 1 , further comprising:an excitation source to excite at least one of the characteristics of the test mixture.3. The portable device of claim 2 , wherein:the excitation source includes at least one of a light source, an electric field source, an electric current source, and a magnetic field source.4. The portable device of claim 1 , wherein:the one or more characteristics including one of more of magnetic, electrical, and optical characteristics.5. The portable device of claim 1 , further comprising:a processor communicatively coupled to the sensor to assess whether the sample contains the analyte based at least in part ...

METHOD AND APPARATUS FOR DETECTING TARGET CHEMICALS WITH TRANSPARENT INDICATOR TAPE

Transparent indicator tape is used for the detection of airborne chemicals in a suspect environment. In various embodiments, the indicator tape is affixed to a window or lens wherein one or more colorimetric indicators clad to the tape are exposed to the environment while humans or detection devices on the other side of the window or lens are not necessarily subjected to the suspect environment. In various embodiments the colorimetric indicator is sensitive to chemical warfare agents. Airborne chemicals including chemical warfare agents may detected by visual review or autonomous measurement of sensor color changes when in the presence of a target chemical. In various embodiments, the an indicator spot is split into sensitive and insensitive regions such that colorimetric changes may be more readily identified against a visually changing background. 1. A system for the passive detection of target airborne chemicals in an environment ,comprising:at least one colorimetric indicator which changes color when exposed to at least one target airborne chemical;{'claim-text': ['wherein the at least one colorimetric indicator is clad to the transparent polymer substrate,', 'wherein the transparent polymer substrate is affixed to an environment facing surface of a transparent window or lens;'], '#text': 'a transparent polymer substrate,'}an optical detector located adjacent to a non-environment facing surface of the transparent window or lens;wherein the transparent polymer substrate is positioned between the optical detector and the environment such that a line of sight from the environment and the optical detector passes through the transparent polymer substrate;whereby when exposed to a target airborne chemical the corresponding colorimetric indicator clad to the transparent polymer substrate changes color, indicating presence of the at least one target airborne chemical.2. The system of wherein the at least one target airborne chemical is a chemical warfare agent.3. The ...

METHOD OF PRODUCING TEST STRIP FOR COLORIMETRIC DETECTION OF CALCIUM CONTENT IN BODY FLUID USING CA-OCPC COMPLEX

The present invention provides a method of producing a test strip for measuring a calcium concentration in a body fluid test sample obtained from a living body (human or animal) by a colormetric change, and a test strip for measuring a calcium concentration in a human or animal body fluid test strip by a colormetric change. 1. A method of producing a test strip for measuring a calcium concentration in a sample obtained from a living body , comprising:(a) immersing paper in a first reagent and drying it; and(b) immersing the dried paper in Step (a) in a second reagent and drying it,wherein the first reagent is prepared by adding and mixing o-cresolphthalein complexone (OPCP), 8-hydroxyquinoline, sodium lauryl sulphate (SDS) and polyvinylpyrrolidone (PVP) in distilled water, and further adding an organic acid, andthe second reagent is prepared by adding and mixing N-cyclohexyl-3-aminopropanesulfonic acid and N-methyl-D-glucamine in distilled water, and further adding Triton X-100 and triethylamine borate.2. The method of claim 1 , wherein the paper is Whatman paper.3. The method of claim 1 , wherein the drying in Step (a) or drying in Step (b) is performed at 55 to 65° C. for 10 to 20 minutes.4. The method of claim 1 , wherein the living body is a human or animal. This application claims priority to and the benefit of Korean Patent Application No. KR 10-2020-0122768 filed on Sep. 23, 2020, the disclosure of which is incorporated herein by reference in its entirety.The present invention relates to a method of producing a test strip that is able to measure a calcium concentration in a fluid sample of a living body (a human or animal) by a colorimetric change.Body fluids such as serum, urine and saliva include abundant biochemical markers excreted from the body. Accordingly, a human body fluid may be analyzed to measure the concentration of a specific metabolite or electrolyte, and a change in the concentration of a specific metabolite or electrolyte shows various ...

Film Sensor

The present disclosure relates to a sensor for indicating food quality comprising a semi-permeable film layer, the semi-permeable film layer comprising at least one integrally formed well having at least one sensing element disposed therein; wherein the well is sealed by a second film layer, the semi-permeable film layer being impermeable to said sensing element but is permeable to at least one analyte detectable by said sensing element.

BIOSENSOR CALIBRATION CODING SYSTEMS AND METHODS

A test sensor () for determining an analyte concentration in a biological fluid comprises a strip including a fluid receiving area () and a port-insertion region (). A first row of optically transparent () and non-transparent positions forms a calibration code pattern () disposed within a first area of the port-insertion region (). A second row of optically transparent () and non-transparent positions forms a synchronization code pattern () disposed within a second area of the port-insertion region (). The second area is different from the first area. The synchronization code pattern () corresponds to the calibration code pattern () such that the synchronization code pattern () provides synchronization of the serial calibration code pattern () during insertion of the port-insertion region () into the receiving port of the analyte meter. 1. A test sensor for determining an analyte concentration in a biological fluid , the test sensor comprising:a strip including a fluid-receiving area and a port-insertion region;a first row of optically transparent and non-transparent positions forming a calibration code pattern disposed within a first area of the port-insertion region; anda second row of optically transparent and non-transparent positions forming a synchronization code pattern disposed within a second area of the port-insertion region, the second area being different from the first area,wherein the synchronization code pattern corresponds to the calibration code pattern such that the synchronization code pattern provides synchronization of the calibration code pattern during insertion of the port-insertion region into a receiving port of an analyte meter.2. The test sensor of claim 1 , wherein the calibration code pattern and the synchronization code pattern include at least one aperture in the strip claim 1 , the at least one aperture defining one or more of the optically transparent positions.3. The test sensor of claim 1 , wherein the calibration code pattern has ...

IMMUNOASSAY KIT

Differing from conventional lateral flow immunoassay test strips, the present invention provides an immunoassay kit comprising a release strip and a reaction strip. When using this immunoassay kit to complete a competitive-type immunochromatographic test or a sandwich-type immunochromatographic test for a test sample, it needs to firstly put the release strip into the test sample for releasing a specific antibody (or antigen) conjugating with a marker into the test sample, so as to make the first antibody connect to a target object in the test sample; after that, the reaction strip is eventually put into the test sample after the release strip is removed out of the test sample. Therefore, the qualitative analysis result of the competitive/sandwich-type immunochromatographic test can be easily obtained by determining whether the test line shows the color reaction or not. 1. An immunoassay kit , used for detecting a target object from a test sample by way of a competitive-type immunochromatographic test , comprising:a release strip, being provided with a first antibody conjugating with a marker thereon; anda reaction strip, being provided with a membrane having a control line and a test line thereon, wherein the control line is formed by a second antibody, and the test line being formed by a conjugate consisting of a specific antigen and a biomolecule;wherein the first antibody is used for connecting to the target object, and the said specific antigen is the antigen of the target object;wherein when completing the competitive-type immunochromatographic test by using the immunoassay kit, the release strip being firstly put into the test sample for releasing the first antibody conjugating with the marker into the test sample, and the reaction strip is eventually put into the test sample after the release strip is removed out of the test sample; therefore, the control line on the reaction strip would show a color reaction when the target object is included by the test ...

System and method for urine analysis and personal health monitoring

A system for urine analysis and personal health monitoring includes a testing box, including a testing chamber, a camera aperture, and a test slot, a color pattern chart, including a bar code, a base color calibration strip, a test result area, and a test lookup area; a diagnostic analysis server, and a diagnostic analysis device, including a processor, a memory, an input output, a diagnostic manager, a camera manager, an image analyzer, a camera calibrator, and a camera; such that the diagnostic analysis device captures an original image of the testing chamber interior with a test strip inserted, and analyzes a diagnostic portion of the original image and calculates a test result. Also disclosed is a method for diagnostic analysis, including installing color pattern chart, depositing sample, inserting test strip, capturing image, performing color calibration, reading barcode, extracting test strip image, performing color conversion, and calculating test result.

Smartphone-Based Apparatus and Method

A method for obtaining a point-of-collection, selected quantitative indicia of an analyte on a test strip using a smartphone involves imaging a test strip on which a colorimetric reaction of a target sample has occurred due to test strip illumination by the smartphone. The smartphone includes a smartphone app and a smartphone accessory that provides an external environment-independent/internal light-free, imaging environment independent of the smartphone platform being used. The result can then be presented quantitatively or turned into a more consumer-friendly measurement (positive, negative, above average, etc.), displayed to the user, stored for later use, and communicated to a location where practitioners can provide additional review. Additionally, social media integration can allow for device results to be broadcast to specific audiences, to compare healthy living with others, to compete in health based games, create mappings, and other applications. 1. A method for obtaining a point-of-collection , selected quantitative indicia of an analyte on a test platform , comprising:providing a modular, colorimetric reactive test platform having a test region and a calibration region;providing an analyte to be tested on the test region of the modular, colorimetric test platform, wherein the test region is adapted to enable a colorimetric reaction to the analyte;obtaining a color image of the test region containing the analyte and the calibration region;selecting an array of pixels in each of the color images of the test region containing the analyte and the calibration region;determining a median RGBA color value for each of the arrays of pixels;converting the median RGBA color value for each of the arrays of pixels to a respective Hue-Saturation-Luminosity (HSL or HSV) test color space value and a HSL or HSV calibration color space value;providing a calibration indicia that relates a selected quantitative indicia of the analyte to a characteristic of the HSL or HSV ...

Optical detection system

An optical detection system includes a light emitting module, a test strip and a receiving module. The light emitting module includes a light source and a first light shielding unit. The first light shielding unit has a first aperture corresponding to the light source. The test strip includes a cassette and a light permeable test paper. The cassette has a first window, a second window and a sample opening disposed on one surface of the cassette. The first and second windows are disposed corresponding to each other and located on opposite sides of the cassette, respectively. The light permeable test paper is disposed in the cassette. The receiving module includes a second light shielding unit and a photo sensor. The second light shielding unit has a second aperture corresponding to the second window. The photo sensor receives the light beam from the light source and outputs a measurement signal.

SYSTEMS AND METHODS FOR NON-FASTING LDL CHOLESTEROL ASSAYS

In one embodiment, a test strip for testing for cholesterol-related blood analytes in whole blood includes a red blood cell separation layer, the red blood cell separation layer separating red blood cells from a blood sample applied to the test strip as the blood sample flows downward through the red blood cell separation layer. The test strip further includes a reaction layer receiving the blood sample from the red blood cell separation layer, the reaction layer including POE-POP-POE block copolymer, a surfactant, and a reflectivity changing reactant, the POE-POP-POE block copolymers solubilizing essentially only non-LDL cholesterol analytes, the non-LDL cholesterol analytes reacting with the reflectivity changing reactant in order to change a reflectivity of the blood sample. 135-. (canceled)36. A method of measuring LDL cholesterol from a human subject providing a blood sample , the method comprising:providing a dry test strip;receiving the blood sample at the dry test strip;separating red blood cells from the blood sample in a first layer of the dry test strip;reacting non-LDL cholesterol in the blood sample in a reaction layer;producing a color change proportional to the non-LDL cholesterol;measuring the color change to determine a non-LDL cholesterol amount in the blood sample; andsubtracting the non-LDL cholesterol amount from a total cholesterol amount in the blood sample to yield an LDL cholesterol amount for the blood sample wherein specificity is such that accuracy is not substantially negatively affected by the presence of chylomicrons.37. The method of claim 36 , wherein the blood sample is from an individual who has not fasted claim 36 , and the resulting LDL cholesterol amount is more accurate than the Friedwald equation.38. The method of claim 36 , wherein the reaction layer further includes a surfactant and a reflectivity changing reactant claim 36 , wherein the reacting includes solubilizing essentially only cholesterol from non-LDL analytes claim ...

URINE TEST DEVICE

A urine test device includes a case in which a guide is formed, a strip tray including a strip moving body formed to be slidably movable through the guide, a plurality of strip seating parts formed on the strip moving body, and a strip fixing part configured to fix the strip seated on each of the plurality of strip seating parts, a tray movement driving part configured to slidably move the strip tray, a sensing module supported by the case and including a plurality of light-emitting diodes (LEDs) configured to emit white light for testing toward the plurality of moving strips from above the plurality of strips and a plurality of image sensors configured to detect colors of the plurality of strips, and a control part configured to control the tray movement driving part to move the strip tray. 1. A urine test device using strips with urine , the urine test device comprising:a case in which a guide is formed;a strip tray including a strip moving body formed to be slidably movable through the guide, a plurality of strip seating parts formed on the strip moving body and allowing strips to be seated thereon, and a strip fixing part configured to fix the strip seated on each of the plurality of strip seating parts;a tray movement driving part configured to slidably move the strip tray in a longitudinal direction;a sensing module supported by the case and including a plurality of light-emitting diodes (LEDs) configured to emit white light for testing toward the plurality of moving strips from above the plurality of strips and a plurality of image sensors configured to detect colors of the plurality of strips to which the white light of the plurality of LEDs is emitted; anda control part configured to control the tray movement driving part to move the strip tray, control the plurality of LEDs to emit the white light toward the plurality of moving strips, and analyze urine on the basis of the colors, which are detected by the plurality of image sensors, of the plurality of ...

UNMANNED VEHICLE BASED DETECTION OF CHEMICAL WARFARE AGENTS

An unmanned vehicle operated autonomously or by remotely piloting incorporates an onboard camera which is affixed with clear tape coated with a chemical colorimetric sensor dye sensitive to chemical warfare agents. Chemical warfare agents are detected by visual review or autonomous measurement of sensor color changes while the unmanned vehicle travels through a region suspected of having chemical warfare agents present. In various implementations, the sensor output color changes may be visually monitored by a vehicle operator viewing the camera image from a remote location. In various embodiments, the detection of chemical warfare agents may be confirmed by processing the coated tape with a calibrated opto-electronic reader. 1. A system for unmanned vehicle based passive detection of target chemical warfare agents comprising:an unmanned vehicle;an onboard camera mounted on the unmanned vehicle;a transparent polymer substrate having at least one corresponding colorimetric indicator coating wherein the at least one corresponding colorimetric indicator coating changes color when exposed to at least one target chemical warfare agent;wherein the transparent polymer substrate is affixed to the onboard camera; andwhereby when exposed to the at least one target chemical warfare agent, the at least one corresponding colorimetric indicator coating changes color, indicating presence of the at least one target chemical warfare agent in physical proximity to the unmanned vehicle.2. The system of wherein the at least one target chemical warfare agent is chosen from the group consisting of: a nerve agent claim 1 , a blister agent claim 1 , a blood agent.3. The system of wherein the at least one target chemical warfare agent is chosen from the group consisting of: sarin gas claim 1 , soman gas claim 1 , vx gas claim 1 , chlorine gas claim 1 , phosgene vapor claim 1 , chlorine gas claim 1 , cyanide gas.4. The system of also comprising an opto-electronic reader capable of discerning ...

METHOD FOR EVALUATING SUITABILITY OF LIGHTING CONDITIONS FOR DETECTING AN ANALYTE IN A SAMPLE USING A CAMERA OF A MOBILE DEVICE

A method of evaluating suitability of lighting conditions for detecting an analyte in a sample using a mobile device camera. A test strip is provided for detecting the analyte. A first image of the test strip is captured while an illumination source of the mobile device is turned off and a second image of the test strip is captured while the illumination source is turned on. A sample is applied to the test strip and the first and second images are compared to thereby determine the difference in lighting conditions between the first image and the second image. The comparison is used to derive information on suitability of the lighting conditions for analyte detection. The lighting conditions are indicated as suitable when a predetermined threshold amount of light intensity used for illumination of the test strip originates from the illumination source. 1. A method of evaluating suitability of lighting conditions for detecting an analyte in a sample using a mobile device camera , the method comprising:a) providing a test strip configured for detecting the analyte in the sample and having a test field with a test chemical for an optical detection reaction;b) capturing a first image of the test strip while an illumination source of the mobile device is turned off;c) capturing a second image of the test strip while the illumination source is turned on, wherein the illumination source generates illumination having a known or predetermined intensity spectrum;d) applying a sample to the test strip prior to steps b) and/or c);e) comparing the first and second images and thereby determining a difference in lighting conditions between the first image and the second image, wherein the camera captures the images in steps b) and c) in at least one color channel and the camera and/or a processor of the mobile device determines first and second intensity distributions, respectively, for the color channels associated with the first and second images, wherein the comparing the first ...

SYSTEMS AND METHODS FOR A LATERAL FLOW TEST STRIP HOLDER

A system of detecting a blood analyte includes a lateral flow test strip and a test strip holder, the lateral flow test strip located in the test strip holder. The system further includes a meter for receiving the test strip holder. 1. A system of detecting a blood analyte , comprising:a lateral flow test strip;a test strip holder, the lateral flow test strip located in the test strip holder; anda meter for receiving the test strip holder.2. The system of claim 1 , further comprising a wicking membrane located in the test strip holder.3. The system of claim 2 , wherein the test strip holder includes a lid and a base.4. The system of claim 3 , wherein the lid includes a dosing window claim 3 , and the wicking membrane is located under the dosing window.5. The system of claim 4 , wherein the base includes a reading window.6. The system of claim 5 , wherein the base includes a base cavity that receives the lateral flow test strip and the wicking membrane.7. The system of claim 6 , wherein the base cavity includes a ledge that causes a sample to flow toward the lateral flow test strip from the wicking membrane.8. The system of claim 7 , wherein the lid is flush with a top of the lateral flow test strip when the lid is engaged with the base claim 7 , such that excess fluid may not flow on top of the lateral flow test strip.9. The system of claim 8 , wherein the lid interfaces with the base in a pressure fit arrangement.10. The system of claim 9 , wherein the lid includes wings and snaps into the base.11. The system of claim 10 , wherein an underside of the lid includes ribs for holding the lateral flow test strip in place.12. The system of claim 11 , wherein the lid compresses the lateral flow test strip into the base.13. The system of claim 12 , wherein the meter includes a slot for receiving the lateral flow test strip and test strip holder combination claim 12 , and the reading window aligns with a sensor of the meter.14. A test strip assembly comprising:a lateral ...

Automatic Vehicle Fluid Detection Sheet

The current invention is an automotive fluid identifier sheet. The sheet is a treated paper that will react to the liquids that drip from the vehicle to change colors. Examples of fluids in a regular car are Gas, Transmission fluid, Windshield wiper fluid, Brake fluid, and Power steering fluid. The sheet will assign a different color to each fluid to show which fluid to show the users what fluid has leaked. 1. A device comprising:automotive fluid identifier sheet that will change colors when a fluid is placed on it where the color is unique to the fluid.2. A device according to comprising:Being comprised of a flat paper sheet.3. A device according to comprising:Where the fluid comprises of one or more of a set of Gas, Transmission fluid, Windshield wiper fluid, Brake fluid, and Power steering fluid.4. A device according to comprising:Where the sheet is placed under a vehicle. None.The present invention generally relates to identifying fluids dripping from a vehicle and more specifically a sheet that goes below a vehicle.A person doesn't have to be a car enthusiast or professional mechanic to know that leaking fluid from their car is potentially problematic. But how do they tell if they have serious problems on their hands or something that can be fixed with a simple inspection?There is still room for improvement in the art.The current invention is Automotive Fluid Identifier system and device that is easily and safe to use.The Automotive Fluid Identifier sheet is placed and located below the vehicle. It will identify the type of fluid that the vehicle is losing and giving an idea of how much it will cost to fix,The majority of leaks coming off a vehicle indicate a potential problem to a vehicle. To understand what that fluid is will help the owner diagnose the problem.The current invention is an automotive fluid identifier sheet which a treated paper that will react to the liquid drip to change colors and help the owner identify the problem and the potential repair ...

Methods for Multiplexing Recombinase Polymerase Amplification

This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes. 178.-. (canceled)79. A device , comprising ,a reaction chamber containing dried reagent composition for a preforming a recombinase polymerase amplification (RPA) comprising(i) at least one recombinase,(ii) at least one polymerase;(iii) a first and second nucleic acid primer;(iv) a third extension blocked primer which comprises an elongation blocking group at the 3′ end, an internal tetrahydrofuran (THF) residue; and(v) at least one nuclease; anda lateral flow strip configured to detect the amplified product.80. The device of claim 79 , wherein the dried reagent composition further comprises a single-stranded DNA binding protein claim 79 , ATP or an ATP analog claim 79 , dNTP(s) claim 79 , or a recombinase loading protein.81. The device of claim 80 , wherein the dried reagent composition comprises T4 bacteriophage UvsX claim 80 , T4 bacteriophage single-stranded DNA binding protein (gp32) and DNA polymerase.82. The device of claim 79 , wherein the first nucleic acid primer claim 79 , the second nucleic acid primer claim 79 , or both is labeled with a detectable label selected from the group consisting of enzymes claim 79 , enzyme substrates claim 79 , coenzymes claim 79 , enzyme inhibitors claim 79 , fluorescent markers claim 79 , chromophores claim 79 , luminescent markers claim 79 , radioisotopes claim 79 , and a member of a binding pair.83. The device of claim 79 , wherein the third extension blocked primer is labeled with a detectable label selected from the group consisting of enzymes claim 79 , enzyme substrates claim 79 , coenzymes claim 79 , enzyme inhibitors claim 79 , fluorescent markers claim 79 , chromophores claim 79 , luminescent markers claim 79 , radioisotopes claim 79 , and a member of a ...

TEST STRIP FOR DETECTING MICROALBUMIN IN URINE WITH HIGH SENSITIVITY

Disclosed is a test strip for detecting microalbumin in urine, and more particularly a test strip for detecting microalbumin in urine that contains a synthetic albumin indicator, a buffer solution, a surfactant and a polymer (sensitizer) and thus exhibits high sensitivity. The albumin detection test strip has accuracy sufficient to enable clear observation of color change from colorless to blue through the albumin indicator, and improves the detection limit (increases sensitivity) to thereby enable detection of microalbuminuria at a concentration of mg/L or less. The albumin test detection strip contains a surfactant and a polymer in addition to a synthetic albumin indicator, thereby incorporating separate first and second processes into a single process and having effects of reducing costs, improving processing convenience, and increasing solubility and miscibility. 1. A method for producing an albumin detection test substrate comprising:(a) adding a surfactant, a sensitizer and an albumin indicator to a buffer solution to prepare an impregnation solution; and(b) impregnating a substrate with the impregnation solution and drying the substrate to obtain the albumin detection test substrate,wherein the buffer solution is prepared by mixing ethanol, citric acid and trisodium citrate.2. The method according to claim 1 , wherein the buffer solution is prepared by slowly mixing 20 to 40 parts by weight of citric acid and 10 to 30 parts by weight of trisodium citrate based on 100 parts by weight of ethanol.3. The method according to claim 1 , wherein the surfactant is Triton X-100.4. The method according to claim 1 , wherein the sensitizer is polypropylene glycol.6. The method according to claim 1 , wherein the albumin indicator is 5′ claim 1 ,5″-dinitroso-3′ claim 1 ,3″ claim 1 ,3 claim 1 ,4 claim 1 ,5 claim 1 ,6-hexabromophenolsulfonephthalein.7. The method according to claim 1 , wherein the substrate is paper claim 1 , nonwoven fabric or sponge.8. A method of producing ...

Methods and Systems for Analyzing a Liquid Medium

Methods and systems for colorimetrically analyzing a liquid medium by analyzing chemical test strip images are provided. The liquid medium can be industrial water in an industrial water system. Image analyzing software carries out the analysis. The results of the analysis can be used to diagnosing a chemical treatment regimen of the industrial water system. A chemical test strip holder can be used to enhance reliability and repeatability of the imaging process and/or subsequent analysis. 1. A method of determining concentration of a chemical species in a liquid medium , the method comprising:exposing a reactive zone of a chemical test strip to the liquid medium thereby creating a post-exposure reactive zone;imaging the post-exposure reactive zone using an imaging device thereby creating a digital image of the post-exposure reactive zone;optionally cropping the digital image of the post-exposure reactive zone to isolate a portion of the digital image for analysis;analyzing a colorimetric parameter of at least the portion of the digital image of the post-exposure reactive zone using the image analyzing software to determine the concentration of the chemical species;optionally outputting the determined concentration of the chemical species of the liquid medium.2. The method of claim 1 , wherein the liquid medium is water.3. The method of claim 2 , wherein the chemical species is selected from dissolved calcium claim 2 , acidity claim 2 , total hardness claim 2 , ortho-phosphate claim 2 , m-alkalinity claim 2 , p-alkalinity claim 2 , an oxidizing biocide claim 2 , or a non-oxidizing biocide.4. The method of claim 3 , wherein the chemical species is an oxidizing biocide.5. The method of claim 4 , wherein the oxidizing biocide comprises one or more stabilized oxidant or halogenated oxidant.6. The method of claim 4 , wherein the oxidizing biocide is a halogenated oxidant.7. The method of claim 6 , wherein the halogenated oxidant is selected from chlorine bleach claim 6 , ...

Hydrogen sensitive films and sensors produced therefrom

Described are sensors and methods of detecting hydrogen gas. The sensor includes a polymer matrix and a dye molecule in an amount sufficient such that exposure of the polymer matrix to hydrogen gas causes a change in a spectroscopic property of the dye molecule wherein the spectroscopic property includes at least one of color, absorbance, or luminescence. The polymer matrix may further include a catalyst, such as a transition metal, sulfonated Wilkinson's catalyst, colloidal Pt, sulfonated iridium cyclooctadiene triphenylphosphine, sulfonated rhodium cyclooctadiene triphenylphosphine, sulfonated ruthenium triphenylphosphine, or combinations thereof. Embodiments of the sensor may further include a gas permeable, water impermeable membrane, an outer covering, or combinations thereof.

METHODS FOR MULTIPLEXING RECOMBINASE POLYMERASE AMPLIFICATION

This disclosure provides for methods and reagents for rapid multiplex RPA reactions and improved methods for detection of multiplex RPA reaction products. In addition, the disclosure provides new methods for eliminating carryover contamination between RPA processes. 1. A RPA process of DNA amplification of a target nucleic acid molecule comprising a first and a second strand of DNA , comprising the steps of:(a) contacting a recombinase agent with a first and a second nucleic acid primer and a third extension blocked primer which comprises one or more noncomplementary or modified internal residue to form a first, second and third nucleoprotein primer;(b) contacting the first and second nucleoprotein primers to said double stranded target nucleic acid thereby forming a first double stranded structure between said first nucleoprotein primer and said first strand of DNA at a first portion of said first strand and a second double stranded structure between said second nucleoprotein primer and said second strand of DNA at a second portion of said second strand such that the 3′ ends of said first nucleoprotein primer and said first nucleoprotein primer are oriented toward each other on the same target nucleic acid molecule with a third portion of target nucleic acid between said 3′ ends;(c) extending the 3′ end of said first nucleoprotein primer and second nucleoprotein primer with one or more polymerases and dNTPs to generate a first amplified target nucleic acid with an internal region comprising the third portion of nucleic acid;(d) contacting said amplified target nucleic acid to said third nucleoprotein primer to form a third double stranded structure at the third portion of said amplified target nucleic acid in the presences of a nuclease; wherein said nuclease specifically cleaves said noncomplementary internal residue only after the formation of said third double stranded structure to form a third 5′ primer and a third 3′ extension blocked primer;(e) extending the ...

SELF-FUSING SILICONE TAPE FOR SENSING HYDROGEN AND HYDROGEN SULFIDE GAS LEAKS

This invention relates to a tape product, and method of manufacturing the product, which incorporates a gas sensing pigment that causes the tape to change color upon exposure to gases such as hydrogen or hydrogen sulfide. The gas sensing pigment is compounded together with a silicone rubber to produce a self-fusing silicone tape which may be applied in a variety of industrial environments where hydrogen or hydrogen sulfide gas leakage is a concern. The tape may be colored to enhance visibility and/or to indicate which hazardous gas it is intended to detect. The tape may be fiber reinforced with carbon fiber to increase its longitudinal strength for industrial applications. Periodic perforations across the width of the tape may be added to facilitate the tearing or cutting of convenient lengths of the tape. 1. A self-sealing silicone tape product comprising: one or more strips of silicone rubber tape , having embedded in the silicone a chemochromic metal oxide particles of tungsten oxide or molybdenum oxide , and a one of a catalyst of metallic platinum or silver , wherein the catalyst coating applied to each microscopic metal oxide particle as nano-scale metallic particles.2. The product of claim 1 , wherein the nanoparticles of the catalyst material are sized in a range of 2 nanometers to 30 nanometers.3. The product of claim 1 , wherein the nanoparticles of the catalyst material are sized in a range of 31 nanometers to tens of nanometers.4. The product of claim 1 , wherein the microparticles of chemochromic metal oxide material are sized in a range of 10 to 200 microns in diameter.5. The product of claim 1 , wherein one of a silicone tape layer has embedded therein a carbon fiber thread having a transverse spatial pattern such that the thread increases the tear resistance while insuring the elastic limit of the strips of tape is maintained.6. The product of claim 5 , wherein the transverse spatial pattern is in the form of triangular steps.7. The product of claim ...

Test piece for albumin measurement

A dry test piece for albumin measurement is based on the improved BCP method as a principle, and enables the measurement of albumin at a high sensitivity. The test piece includes a support; and a reagent holding layer provided on the support and on which a sample is spotted. The reagent holding layer contains a protein denaturation agent (component A), an SH reagent (component B), bromcresol purple (component C), and a nonionic surfactant (component D). In the reagent holding layer, a weight ratio (D/C) of the component D to the component C is 0.3 to 13, a content of the component C relative to an amount of the spotted sample is 0.4 μg/μL to 5.4 μg/μL, a content of the component D relative to the amount of the spotted sample is 25 μg/μL or less.

APPARATUS FOR SIMULTANEOUS DETECTION OF AMINES AND THIOLS

Disclosed is an apparatus for simultaneous detection of amines and thiols. 1. An apparatus for the simultaneous detection of amines and thiols , the apparatus comprising a thiol-detection reagent and an amine-detection reagent immobilized onto one or a plurality of pad matrices.2. An apparatus according to claim 1 , wherein the one or a plurality of pad matrices is affixed to a plastic backing.3. An apparatus according to claim 1 , wherein the thiol-detection reagent and the amine-detection reagent are immobilized onto a plurality of pad matrices.4. An apparatus according to claim 1 , wherein the thiol-detection reagent and the amine-detection reagent are immobilized onto one pad matrix.5. An apparatus according claim 1 , wherein the thiol-detection reagent comprises DTNB.6. An apparatus according to claim 1 , wherein the amine-detection reagent comprises OPA or fluorescamine.7. An apparatus according to claim 1 , wherein the amine-detection reagent comprises OPA.8. An apparatus according to claim 1 , wherein the thiol-detection reagent comprises DTNB and the amine-detection reagent comprises OPA.9. An apparatus according to for direct in situ contact with a fluid sample.10. An apparatus according to in the form of a test strip.11. An apparatus according to for contact with a fluid sample that has been collected by a second apparatus.12. An apparatus according to in the form of a test strip.13. An apparatus according to claim 11 , wherein the thiol-detection reagent and the amine-detection reagent are immobilized onto a plurality of pad matrices.14. An apparatus according to claim 13 , wherein the thiol-detection reagent is immobilized onto a first pad matrix and the amine-detection reagent is immobilized onto a second pad matrix claim 13 , and wherein the first pad matrix and the second pad matrix may be simultaneously contacted with the second apparatus.15. An apparatus according to claim 14 , wherein the first pad matrix and the second pad matrix may be ...

METHODS AND SYSTEM FOR PERFORMANCE ASSESSMENT OF CLEANING OPERATIONS

The present disclosure relates to a process and a system for assessing the performance of cleaning operations by utilizing an automatic read out routine for test strips subjected to a cleaning operation. Furthermore, the present disclosure relates to a computer program product capable of performing the process. 1. Process for the performance assessment of cleaning operations at least comprising the steps of:a) exposing at least one chemical test strip comprising a carrier and an indicator means, wherein the indicator means comprises at least in a defined surface area a color indicator, to the chemical environment of a cleaning operation;b) recording with an image device the data of at least one digital color image of the test strip after the cleaning operation; andc) quantitative evaluation of the digital image data, c1) color-to-greyscale image data transformation;', 'c2) glare detection;', 'c3) greyscale- to binary image data transformation;', 'c4) image pixel-area normalization; and step', 'c5) pixel-counting, wherein the number of black and white pixels of the test strip image data after the cleaning process are counted and the counting result is compared to the quantitative evaluation result of the test strip prior to the cleaning process., 'characterized in that the quantitative evaluation of the digital color image data in step c) at least comprises the steps c1) to c5)3. Process according to claim 1 , wherein the greyscale- to binary image data transformation in step c3) is achieved by an adaptive threshold transformation.5. Process according to claim 4 , wherein the mean greyscale-value of the pixel neighborhood is calculated from a 251×251 matrix around the pixel(x claim 4 ,y) and the constant C is 5.6. Process according to claim 1 , wherein the glare detection in step c2) at least comprises the transformation of the digital color image data into a HSV-color domain and performing a glare detection based on the V(x claim 1 ,y)-value of individual pixels or ...

SAMPLE COLLECTOR

The present invention relates to a sample collector comprising: an inner flexible collection bag having an opening along its upper edge at least when open for use; and an outer support for supporting the collection bag at its opening. The support has sides that can fold together for storage and open to provide a structure in which one end has a spout and another end has a transverse portion. The sides include fold lines to enable bending of the sides from a storage configuration into an open configuration. The collection bag being connected to the outer support such that on opening of the outer support the bag is held open for collection of a sample. 131-. (canceled)32. A sample collector comprising:an inner flexible collection bag having an opening along its upper edge at least when open for use; andan outer support for supporting the collection bag at its opening, the support having sides that can fold together for storage and open to provide a structure in which one end has a spout and another end has a transverse portion, the sides including fold lines to enable bending of the sides from a storage configuration into an open configuration,the collection bag being connected to the outer support such that on opening of the outer support the bag is held open for collection of a sample.33. A collector as claimed in claim 32 , in which the collection bag comprises a removable extension extending above the opening of the collection bag.34. A collector as claimed in claim 32 , in which in the outer support forms a prism configuration having a substantially triangular or wedge shaped cross-section in the open position.35. A collector as claimed in claim 32 , in which in the open position the opening has at least three sides.36. A collector as claimed in claim 35 , in which in the open position the transverse portion is substantially square or rectangular in shape.37. A collector as claimed in claim 32 , in which the outer support is substantially flat in the storage ...

BIOSENSOR CALIBRATION CODING SYSTEMS AND METHODS

A test sensor () for determining an analyte concentration in a biological fluid comprises a strip including a fluid receiving area () and a port-insertion region (). A first row of optically transparent () and non-transparent positions forms a calibration code pattern () disposed within a first area of the port-insertion region (). A second row of optically transparent () and non-transparent positions forms a synchronization code patient () disposed within a second area of the port-insertion region (). The second area is different from the first area. The synchronization code pattern () corresponds to the calibration code pattern () such that the synchronization code pattern () provides synchronization of the serial calibration cede pattern () during insertion of the port-insertion region () into the receiving port of the analyte meter. 128-. (canceled)29. A biosensor for determining an analyte concentration in a biological fluid , the biosensor comprising:a strip including a fluid-receiving area and a port-insertion region;one or more sensor contacts at least partially disposed in the port-insertion region and configured to allow a transfer of electrical signals during insertion of the port-insertion region into a receiving port of an analyte meter;a row of optically transparent and non-transparent positions forming a synchronization code pattern disposed within a first area of the port-insertion region, the first area being different from another area of the port-insertion region containing a calibration code pattern,wherein the synchronization code pattern corresponds to the calibration code pattern such that the synchronization code pattern provides synchronization of the calibration code pattern following insertion of the port-insertion region into the receiving port.30. The biosensor of claim 29 , wherein the synchronization code pattern includes at least one aperture in the strip claim 29 , the at least one aperture defining one or more of the optically ...

Portable, Rapid, and Inexpensive Diagnostic Tests for Cardiac Disease Risk

Cardiac disease is the world's leading cause of death. Cardiac Disease's pathogenesis is largely attributed to cholesterol, predominantly carried by low-density lipoproteins (LDL). However, recent research has found that oxidized-LDL is significantly more potent in the initiation and development of atherosclerosis. Tests for both cholesterol and ox-LDL tests are lab-based and expensive. With every third American at risk for Cardiac Disease, this invention discloses an on-site, ultra-low cost, rapid diagnostic test. The diagnostic test disclosed will enable a holistic assessment of Cardiac Disease risk. Furthermore, portability and ultra low-cost of the test put vital health data in the hands of patients and doctors. Additionally, the inkjet printing system disclosed can be used to mass produce the test strips on demand. 1. A method of manufacturing an inexpensive diagnostic test , comprising:an enzyme mixture, and a color detector reagent, applied on a substrate or a solid support.2. The method according to claim 1 , further comprising of the step of repurposing a piezoelectric inkjet printer for the purpose of printing diagnostic test strips.3. The method according to claim 1 , further comprising of the step of repurposing a bubble thermal inkjet printer for the purpose of printing diagnostic test strips.4. The method according to claim 1 , comprising of preparation of the ink cartridges for repurposing an inkjet printer for printing reagents.5. The method according to and or and claim 1 , further comprising of the step of inkjet printing the enzyme mixture and color detection reagent as one layer or multiple layers on a substrate or solid support claim 1 , using an inkjet printer.6. The method of claim 5 , wherein the first layer is an enzyme mixture; wherein the second layer is a color detection reagent printed using an inkjet printer.7. The method according to claim 6 , wherein inkjet printing the second layer includes inkjet printing the second layer on top of ...

APPARATUS FOR SIMULTANEOUS DETECTION OF AMINES AND THIOLS

Disclosed is an apparatus for simultaneous detection of amines and thiols. 1. An apparatus for the simultaneous detection of amines and thiols , the apparatus comprising a thiol-detection reagent and an amine-detection reagent immobilized onto one or a plurality of pad matrices.2. An apparatus according to claim 1 , wherein the one or a plurality of pad matrices is affixed to a plastic backing.3. An apparatus according to claim 1 , wherein the thiol-detection reagent and the amine-detection reagent are immobilized onto a plurality of pad matrices.4. An apparatus according to claim 1 , wherein the thiol-detection reagent and the amine-detection reagent are immobilized onto one pad matrix.5. An apparatus according claim 1 , wherein the thiol-detection reagent comprises DTNB.6. An apparatus according to claim 1 , for direct in situ contact with a fluid sample.7. An apparatus according to claim 6 , in the form of a test strip.8. An apparatus according to claim 1 , for contact with a fluid sample that has been collected by a second apparatus.9. An apparatus according to claim 8 , in the form of a test strip.10. An apparatus according to claim 8 , wherein the thiol-detection reagent and the amine-detection reagent are immobilized onto a plurality of pad matrices.11. An apparatus according to claim 10 , wherein the thiol-detection reagent is immobilized onto a first pad matrix and the amine-detection reagent is immobilized onto a second pad matrix claim 10 , and wherein the first pad matrix and the second pad matrix may be simultaneously contacted with the second apparatus.12. An apparatus according to claim 11 , wherein the first pad matrix and the second pad matrix may be simultaneously contacted with the second apparatus through opposition.13. A process for detection and/or monitoring of a physiological claim 11 , pathophysiological and/or environmental condition characterized by a fluctuation in concentration of amines and/or thiols claim 11 , the process comprising ...

BED BUGS DETECTION DEVICE

System and method embodiments for analyzing a test fluid to detect prior or present infestations of bed bugs are described. In an embodiment, the method may include receiving the test fluid on a test strip within the detection device. The test strip may include a reaction portion and a reagent portion containing an antibody or antigen-binding fragment that is conjugated to a colored particle. The test fluid may include bed bug antigen that reacts with the conjugated antibody. The detection device may include a first and a second optical sensor for monitoring a reaction and a background color intensity, respectively. Upon a predetermined time delay elapsing, the detection device determines whether bed bug antigen is present in the test fluid using the monitored color intensities and minimum and maximum color intensity thresholds associated with bed bugs. Then, the detection device outputs a result using a visual display. 1. A method for analyzing a test fluid to determine prior or present infestations of bed bugs , comprising:receiving, by a detection device, the test fluid near a first end of a test strip within the detection device, wherein the test fluid flows past a reagent portion of the test strip containing colored particles and through a reaction portion of the test strip, wherein the reagent portion contains an antibody or antigen-binding fragment thereof that is conjugated to a colored particle, and wherein the conjugated antibody is capable of binding with any bed bug antigen within the test fluid to form a bed bug molecule;monitoring, by a first optical sensor within the detection device, a reaction color intensity of the reaction portion of the test strip, wherein an immobilized antibody or antigen-binding fragment thereof within the reaction portion binding with the bed bug molecule increases the reaction color intensity;monitoring, by a second optical sensor within the detection device, a background color intensity of a portion of the test strip near ...

Sensor Management And Record Tracking System

The present invention is an early infection detection system comprising: a housing having a sensor system section and tray section; an inflow port in fluid communications with a catheter to allow bodily fluid to flow from a patient into the tray section; a color sensor included in the sensor section and in electrical communications with a control module configured to sense the color of a reagent and convert the color to a numeric value representing the amount of a compound, such as bacteria, present in the bodily fluid; a tray carrying a reagent that darkens relative to the amount of the compound present in a bodily fluid that contacts the strip; and, computer readable instructions included in the control module for receiving the numeric value and transmitting the numeric value to a local server. 1. An early infection detection system comprising:a housing having a sensor system section, tray section, and volume section;an inflow port in fluid communications with a catheter to allow bodily fluid to flow from a patient into the tray section;an inflow one way valve configured to prevent bodily fluid from flowing from the tray section toward the catheter once the fluid is present in the tray section;a color sensor included in the sensor section and in electrical communications with a control module configured to sense the color of a reagent and convert the color to a numeric value representing the amount of a compound present in the bodily fluid;a chamber extended into the tray section and receiving the sensor for blocking ambient light;a tray carrying a reagent that darkens relative to the number of bacteria present in a bodily fluid that contacts the strip;a urine meter opening in fluid communications with the tray section and the urine meter allowing bodily fluid to flow from the tray section into the urine meter;a urine meter one way valve configured to prevent bodily fluid from flowing from the urine meter into the tray assembly;a first section and a second section ...

STABILIZED TEST STRIP FOR THE DETECTION OF HYDROGEN PEROXIDE

A colorimetric dry-reagent test strip for direct detection of the presence of hydrogen peroxide in strongly acidic solutions without the necessity of a pH neutralization step comprises a chromogen responsive to hydrogen peroxide, an enzyme peroxidase catalyst and at least one complexing agent. A solution of the components may be applied to a suitable carrier and allowed to dry. The resulting dry test strip is placed in contact with a solution to be tested. The test strip has particular value in the determination of peroxide-based explosive compounds, such as hexamethylene triperoxide diamine (HMTD) or triacetone triperoxide (TATP), which require a treatment with a strong organic acid to release the hydrogen peroxide to be detected, and typically requires neutralization of the acid before a conventional test strip can be employed. The invention dispenses with the need for such a neutralization step. The invention test strip can be incorporated into a kit for the determination of such peroxide-based explosive compounds. The kit may include, in addition to the test strip, only a solvent to dissolve a sample to be tested and the strong mineral acid to degrade the sample. 1. A colorimetric dry-reagent test strip for direct detection of the presence of hydrogen peroxide in strongly acidic solutions without the necessity of a neutralization step , comprising a chromogen responsive to hydrogen peroxide , an enzyme peroxidase catalyst and at least one complexing agent.2. The test strip of claim 1 , wherein the enzyme peroxidase is horseradish peroxidase having both acidic and basic isoenzymes.3. The test strip of claim 1 , wherein the at least one complexing agent is chosen from the group consisting of polycarboxylic and polyaminopolycarboxylic compounds.4. The test strip of claim 3 , wherein the polycarboxylic and polyaminopolycarboxylic compounds have three to six carboxylic groups.5. The test strip of including two complexing agents.6. The test strip of wherein the ...

ORTHOGONALLY REDUNDANT SENSOR SYSTEMS AND METHODS

A continuous glucose monitoring system may include a hand-held monitor, a transmitter, an insulin pump, and an orthogonally redundant glucose sensor, which may comprise an optical glucose sensor and a non-optical glucose sensor. The former may be a fiber optical sensor, including a competitive glucose binding affinity assay with a glucose analog and a fluorophore-labeled glucose receptor, which is interrogated by an optical interrogating system, e.g., a stacked planar integrated optical system. The non-optical sensor may be an electrochemical sensor having a plurality of electrodes distributed along the length thereof. Proximal portions of the optical and electrochemical sensors may be housed inside the transmitter and operationally coupled with instrumentation for, e.g., receiving signals from the sensors, converting to respective glucose values, and communicating the glucose values. The sensors' distal portions may be inserted into a user's body via a single delivery needle and may be co-located inside the user's body. 1. A continuous glucose monitoring system comprising: ["an optical glucose sensor having a proximal portion that is configured to be disposed externally to a body of a user and a distal portion configured for internal placement in the user's body; and", "a non-optical glucose sensor having a proximal portion that is configured to be disposed externally to the user's body and a distal portion configured for internal placement in the user's body;"], 'an orthogonally redundant glucose sensor, comprisinga hand-held monitor having a display; andan external transmitter having a housing that houses the proximal portion of the optical glucose sensor and the proximal portion of the non-optical glucose sensor, wherein the transmitter includes instrumentation configured to receive an optical signal from the optical sensor and a non-optical signal from the non-optical sensor and configured to convert each of said optical and non-optical signals to respective ...

MULTI-FLUID STRIP TEST

A multi-fluid test strip may include a first zone to test a first fluid, a second zone to test a second fluid, and a third zone intermediate the first zone and the second zone. The third zone may prevent cross-contamination of the first fluid with the second zone and prevent cross-contamination of the second fluid with the first zone. The multi-fluid test strip may also include a first grip zone and a second grip zone. The first zone may be intermediate the first grip zone and the third zone and the second zone may be intermediate the second grip zone and the third zone. The first grip and second grip zones may be dimensioned to permit gripping of the first and second grip zones without touching the first or second zones. 1. A multi-fluid test strip comprising:a first zone configured to test a first fluid;a second zone configured to test a second fluid; anda third zone configured to prevent cross-contamination of the first fluid with the second zone and the second fluid with the first zone, the third zone intermediate the first zone and the second zone.2. The multi-fluid test strip of claim 1 , further comprising a first grip zone and a second grip zone claim 1 , the first zone intermediate the first grip zone and the third zone and the second zone intermediate the second grip zone and the third zone claim 1 , wherein the first grip zone is dimensioned to permit gripping of the first grip zone without touching the first zone and the second grip zone is dimensioned to permit gripping of the second grip zone without touching the second zone.3. The multi-fluid test strip of claim 2 , wherein the first zone comprises a first test pad configured to test a first aspect of the first fluid and the second zone comprises a second test pad configured to test a second aspect of the second fluid.4. The multi-fluid test strip of claim 3 , wherein the second zone further comprises a third test pad configured to test a third aspect of the second fluid claim 3 , wherein the second ...

Hazardous contaminant collection kit and rapid testing

Contamination detection systems, kits, and techniques are described for testing surfaces for the presence of hazardous contaminants, while minimizing user exposure to these contaminants. Even trace amounts of contaminants can be detected. A collection kit provides a swab that is simple to use, easy to hold and grip, allows the user to swab large areas of a surface, and keeps the user's hands away from the surface being tested. The kit also provides open and closed fluid transfer mechanism to transfer the collected fluid to a detection device while minimizing user exposure to hazardous contaminants in the collected fluid. Contamination detection kits can rapidly collect and detect hazardous drugs, including trace amounts of antineoplastic agents, in healthcare settings at the site of contamination.

SYSTEMS, DEVICES, AND METHODS FOR AMPLIFYING SIGNALS OF A LATERAL FLOW ASSAY

Lateral flow assay devices, systems, and methods described herein detect analyte present in a sample in low quantity or at low concentration by amplifying a signal generated at a detection zone. The generated signal can exceed a detection threshold of a measurement system and increase the sensitivity of the lateral flow assay devices, systems, and methods. In one aspect, the lateral flow device includes a signal-amplification conjugate that binds to a complex bound to immobilized capture agent in the detection zone, causing a chain reaction of binding events in the detection zone that result in an amplification of the signal generated in the detection zone. 1. A lateral flow assay for detecting an analyte of interest in a sample comprising:a first conjugate comprising a first label, an agent configured to specifically bind to the analyte of interest, and a first binding partner;a second conjugate upstream of the first conjugate along a fluid flow path of the lateral flow assay, wherein the second conjugate comprises a second label and a second binding partner configured to specifically bind to the first binding partner; anda detection zone downstream of the first conjugate and the second conjugate along the fluid flow path of the lateral flow assay, the detection zone comprising an immobilized capture agent that specifically binds the analyte of interest.2. The assay of claim 1 , wherein the first conjugate is present in a sample receiving zone of the lateral flow assay claim 1 , or wherein the first conjugate is present in a first conjugate zone downstream of the sample receiving zone.3. The assay of claim 1 , wherein the second conjugate is present in a buffer receiving zone upstream of the sample receiving zone claim 1 , or wherein the second conjugate is present in a second conjugate zone downstream of the buffer receiving zone and upstream of the sample receiving zone.4. The assay of claim 1 , wherein the first conjugate is configured to be solubilized and ...

BIOCHIP FOR MEASURING BLOOD GLUCOSE LEVELS, AND BLOOD GLUCOSE METER FOR SMARTPHONE, CONTAINING SAME

Disclosed are a biochip for measuring blood glucose levels and a blood glucose meter for a smartphone including the same. The biochip for measuring blood glucose levels includes: a substrate, one surface of which is provided with a blood glucose inflow region into which blood glucose flows and with a reaction region that is connected to the blood glucose inflow region and has a recess formed therein, a porous separator disposed on the blood glucose inflow region to face the surface of the substrate, and silica nanoparticles and a reaction reagent distributed on the reaction region of the substrate. Thereby, blood glucose levels can be measured using such a biochip, which is easy to carry, together with a CMOS image sensor, and particularly, blood glucose levels can be simply measured using a CMOS image sensor provided to a smartphone, and blood glucose levels can be quantitatively measured and checked using a blood glucose meter application installed on a smartphone. 1. A biochip for measuring blood glucose levels , comprising:a substrate, one surface of which is provided with a blood glucose inflow region into which blood glucose flows and with a reaction region that is connected to the blood glucose inflow region and has a recess formed therein;a porous separator disposed on the blood glucose inflow region to face the surface of the substrate; andsilica nanoparticles and a reaction reagent distributed on the reaction region of the substrate.2. The biochip of claim 1 , further comprising a cap member disposed on the reaction region of the substrate.3. The biochip of claim 2 , wherein the cap member has a protrusion claim 2 , and a convex portion of the protrusion and a concave portion of the recess are lined up and oriented away from each other to form a space therebetween.4. The biochip of claim 1 , wherein the recess accommodates blood glucose and constitutes a photon detection region.5. The biochip of claim 3 , wherein the space accommodates blood glucose and ...

METHOD FOR DETECTION OF PROTEIN COMPRISING HISTIDINE-TAG USING IMMUNOCHROMATOGRAPHY

The present invention relates to a method for the detection of a protein including a histidine-tag using immunochromatography. The detection method of the present invention uses immunochromatography using the polymer particle fixed with the histidine-tag, wherein a histidine-tag specific antibody alone is used to detect a histidine-tag conjugated protein (recombinant protein) quickly without using a target protein specific antibody. This method is also efficient in detecting and quantifying the histidine-tagged protein included in the sample without using an additional apparatus but quickly and accurately. 1. A method for detection or quantification of a histadine-tagged protein comprising a histidine-tag , said method comprising the step of performing immunochromatography with a mixture of a nanoparticle having the histidine-tagged protein fixed thereon and a sample containing the histidine-tagged protein.2. The method according to claim 1 , wherein the histidine-tagged protein fixed on the nanoparticle comprises a sequence of 5 to 6 histidine residues.3. The method according to claim 1 , wherein the nanoparticle is one or more metal particles selected from the group consisting of gold claim 1 , silver claim 1 , and white gold particles; or a polymer particle.4. The method according to claim 3 , wherein the polymer particle is a cellulose nanobead.5. The method according to claim 1 , wherein a size of the nanoparticle is 50 to 400 nm.6. The method according to claim 1 , wherein the histidine-tag fixed on the nanoparticle competes with the histidine-tagged protein included in the sample during immunochromatography.7. The method according to claim 1 , wherein the sample is a cell extract expressing the histidine-tagged protein.8. The method according to claim 1 , wherein the method comprises the following steps:(a) mixing the nanoparticle on which the histidine-tagged protein is fixed and the sample containing the histidine-tagged protein to provide the mixture;(b) ...

Method and system for measuring biochemical information using color space conversion

A method according to an embodiment of the present invention includes acquiring an image of a urine test kit equipped with a biochemical sample rod including a plurality of pad cells including a plurality of sub-pad cells, extracting at least one potential RGB value from the image by means of a potential color extractor, and converting and analyzing the at least one potential RGB value using a plurality of color spaces included in a color space conversion engine and a color space analysis engine by means of an analyzing unit. The plurality of color spaces are randomly generated, and a color space having a smallest distance value from the potential RGB value is determined as an optimal color space.

TOUGH HYDROGEL COATING AND METHOD OF MANUFACTURE

Hydrogel-substrate laminate structures and tough biocompatible hydrogel coatings for various equipment such as medical devices and underwater equipment, in which robust interfaces are formed between the hydrogel coatings and the substrate/equipment surface(s). The hydrogel coatings provide a highly-hydrated, ultra-low friction structure that does not rupture or delaminate under stress. The hydrogel coatings may further incorporate a variety of therapeutic agents and/or sensing mechanisms to provide for environmental sensing and therapeutic agent release. 1. A hydrogel-substrate laminate comprising:a layer of substrate having a top surface and a bottom surface, the substrate selected from elastomers, plastics, glass, ceramics and metals;at least one hydrogel coating layer disposed on one or more of the top surface and the bottom surface of the substrate; andone or more therapeutic agent disposed within the at least one hydrogel coating layer, and/or one or more sensing material disposed within the at least one hydrogel coating layer.2. The hydrogel-substrate laminate according to claim 1 , wherein a first hydrogel coating layer is disposed on the top surface of the substrate layer claim 1 , and a second hydrogel coating layer is disposed on the bottom surface of the substrate layer.3. The hydrogel-substrate laminate according to claim 2 , wherein the layer of substrate is impermeable to small molecules claim 2 , a first therapeutic agent is disposed within the first hydrogel coating layer claim 2 , and a second therapeutic agent different than or the same as the first therapeutic agent is disposed within the second hydrogel coating layer.4. The hydrogel-substrate laminate according to claim 2 , wherein the layer of substrate is impermeable to small molecules claim 2 , a first sensing material is disposed within the first hydrogel coating layer claim 2 , and a second sensing material different than or the same as the first sensing material is disposed within the ...

URINE BOWEL APPARATUS AND METHOD FOR MAKING THE SAME

An apparatus for urine sample collection and testing is provided. The apparatus has at least one chamber for receiving the urine sample. The chamber has a test component used to analyze one or more parameters of a urine sample. The chamber may have a plurality of compartment, with each compartment having a test component used to analyze a plurality of parameters of multiple urine samples. The test component may have a color change indicative of various characteristics of a parameter. The apparatus also provides a color scale with a plurality of reference colors for use in comparing with the color change produced in the analyzed urine sample. 1. An apparatus for urine sample collection and testing , the apparatus comprising:at least one chamber;a test component present in said at least one chamber,a color scale having a plurality of reference colors for comparison with said color change, wherein one of the plurality of reference colors represent a normal value;a top portion having an opening, the opening configured to receive the urine sample and direct the urine sample to said at least one chamber for analysis; anda lid for closing the opening.2. The apparatus of claim 1 , wherein the apparatus is bottle shaped.3. The apparatus of claim 1 , wherein said test component is configured to analyze a urine sample for at least one parameter.4. The apparatus of claim 1 , wherein the apparatus is configured to detect multiple parameters.5. The apparatus of claim 4 , the at least one chamber has a plurality of compartments claim 4 , each of said plurality of compartments has a test component configured to analyze the urine sample.6. The apparatus of claim 1 , wherein the test component is a test strip claim 1 , said test strip including a chemical reagent claim 1 , the chemical reagent configured to react with the urine sample to generate a color change.7. The apparatus of claim 1 , wherein the apparatus is made of plastic.8. The apparatus of claim 1 , wherein the parameter ...

Detection method and detection device with compensation function

A detection method with a compensation function includes the following steps. After a sample is added to a first cassette, a first triggering instruction is provided to define a first time point. The start position of the reaction area of the first cassette is detected, and a second time point is defined when a first light detecting signal greater than or equal to a predetermined value is obtained. After a predetermined time, a second light detecting signal is obtained from a color band of the reaction area. The time difference between the first time point and the second time point is calculated and the time difference is designated as a first retention time. A compensation value is obtained in a lookup table according to the first retention time and the second detecting signal and the second detecting signal is compensated by the compensation value.

METHODS, SYSTEMS, AND APPARATUSES FOR MEASURING CONCENTRATION OF GASES

Various embodiments described herein, relates to a filter-less particle separation unit (FLPS) for a gas monitoring system. The filter-less particle separation unit includes, an inlet that defines an annular flow passage to facilitate an inflow of a fluid in the FLPS. In this regard, the annular flow passage between a first end and a second end of the inlet, defines an acceleration nozzle that is operable to accelerate the inflow, and eject the fluid at a defined volumetric flow rate. The FLPS further includes, a particle separating zone having a cavity of a defined form factor. The particle separation zone is operable to separate any particulate material that may be present in the fluid. Further, the FLPS includes an outlet operable to facilitate an outflow of filtered fluid to an input port of the gas monitoring system that measures a concentration of a reactive gas present in the fluid. 1. A filter-less particle separation unit for a gas monitoring system comprising:an inlet having a first end and a second end that defines an annular flow passage operable to facilitate an inflow of a fluid, the annular flow passage defines an acceleration nozzle between the first end and the second end that is operable to accelerate the inflow and eject the fluid at a defined volumetric flow rate;a particle separation zone, extending outwardly from the acceleration nozzle, wherein the particle separation zone comprises at least one cavity having a defined form factor and operable to separate particulate material from the fluid; andan outlet, extending outwardly from one end of the particle separation zone, the outlet operable to facilitate an outflow of filtered fluid to an input port of the gas monitoring system that measures a concentration of a reactive gas present in the fluid.2. The filter-less particle separation unit of claim 1 , wherein the at least one cavity of the particle separation zone is operable to generate a self-cleaning stream pattern of the fluid to separate ...

Optochemical sensor unit and a method for the qualitative and/or quantitative determination of an analyte in a measuring medium with the sensor unit

An optochemical sensor unit including: an optical waveguide; a transmitting unit for emitting a first transmission signal for exciting a luminophore; a receiving unit for receiving a received signal comprising a signal component emitted by the excited luminophore; a measuring chamber for receiving a fluid, wherein the fluid includes magnetic microspheres; a membrane arranged between the measuring chamber and a measuring medium for exchanging an analyte between the measuring medium and the fluid in the measuring chamber, wherein the measuring diaphragm is impermeable to the magnetic microspheres; and an electromagnet for attracting magnetic microspheres to a sensor membrane with a fluid-contacting surface and/or to a fluid-contacting surface of the optical waveguide, or to a surface of a transparent substrate layer of the optical sensor unit that is connected to the optical waveguide.

Gas detection system and gas detection method

A gas detection system includes (1) an output device configured to output data acquired by monitoring a gas sensing element including a gas detection layer including a pigment; and (2) an information processing apparatus configured to process the data output by the output device, wherein the information processing apparatus includes a determining unit configured to determine whether the gas sensing element has detected gas, based on the data, and a display control unit configured to display, on an indication element, information indicating a position of the gas sensing element that has detected the gas or information indicating a status of gas leakage determined based on the data, when the determining unit determines that the gas sensing element has detected the gas.

Apparatuses, methods, and systems for home monitoring of physiological states and conditions

Methods, systems and apparatuses for monitoring a physiological condition of a user. The apparatus includes a housing, a processor, a power source, a receptacle configured to receive an inserted test strip, an imaging unit configured to image the inserted test strip, and a communication unit configured to communicate data received from the imaging unit to a communication network. The apparatus is configured to read color change results produced by more than one different type test strip, and the more than one different type of test strip each produce a different color to indicate the presence of an analyte. The apparatus may include two separate but connectable units: an analyte sensing unit and a base unit. The apparatus may further include a temperature sensing unit which may alternatively connect with the base unit. The apparatus may communicate with a mobile application on a hand held device.

BIOSENSOR CALIBRATION CODING SYSTEMS AND METHODS

A test sensor () for determining an analyte concentration in a biological fluid comprises a strip including a fluid receiving area () and a port-insertion region (). A first row of optically transparent () and non-transparent positions forms a calibration code pattern () disposed within a first area of the port-insertion region (). A second row of optically transparent () and non-transparent positions forms a synchronization code pattern () disposed within a second area of the port-insertion region (). The second area is different from the first area. The synchronization code pattern () corresponds to the calibration code pattern () such that the synchronization code pattern () provides synchronization of the serial calibration code pattern () during insertion of the port-insertion region () into the receiving port of the analyte meter. 128-. (canceled)29. A test sensor comprising:a strip including a fluid-receiving area and a port-insertion region;one or more sensor contacts at least partially disposed in the port-insertion region, the one or more sensor contacts configured to complete a detection circuit with one or more sensor interfaces of a receiving port of an analyte meter causing a signal to be received by the analyte meter to initiate instructions for a pattern read device to begin transmitting light waves;a row of optically transparent and non-transparent positions forming a synchronization code pattern disposed within a first area of the port-insertion region, the first area being different from another area of the port-insertion region including a calibration code pattern,wherein the synchronization code pattern corresponds to the calibration code pattern such that the synchronization code pattern provides synchronization of the calibration code pattern during insertion of the port-insertion region into the receiving port.30. The test sensor of claim 29 , wherein the synchronization code pattern includes at least one aperture in the strip defining one or ...

System for monitoring and managing biomarkers found in a bodily fluid via client device

Embodiments disclosed herein relate to a method monitoring a level of a biomarker found in a bodily fluid of a user. The client device receives an indication to capture a biomarker level reading of a test pad on a test strip. The test pad contains a reactant disposed thereon that, when placed into contact with a sample of the bodily fluid, displays a color related to a level of concentration of the biomarker in the bodily fluid. The client device identifies, with a camera, a portion of the test strip containing the test pad displaying the color related to the concentration level of the biomarker. The client device identifies the color displayed on the test strip. The client device correlates the identified color displayed on the test strip to the level of the biomarker. The client device updates the account of the user with the determined biomarker level.

REUSABLE OPTICAL FIBER APTASENSOR BASED ON PHOTO-THERMAL EFFECT

The present invention relates to a reusable optical fiber aptasensor using a photo-thermal effect, and more particularly, to a reusable optical fiber aptasensor using white light and a laser. The aptasensor includes a light emitting unit for selectively emitting one of white light and a laser, a sensor unit including a plurality of aptamers, a plurality of gold nanorods, and a silver mirror, a detector for analyzing a wavelength of inputted light, and an optical fiber for connecting the light emitting unit with the sensor unit, and connecting the detector with the sensor unit, wherein the light emitted from the light emitting unit is totally reflected in the optical fiber and irradiated to the sensor unit, and light reflected from the silver mirror of the sensor unit is irradiated to the detector. Accordingly, the aptasensor easily measures concentration of a target material in a sample using the optical fiber. 1. An aptasensor comprising:a light emitting unit for selectively emitting one of white light and a laser;a sensor unit including a plurality of aptamers, a plurality of gold nanorods, and a silver mirror;a detector for analyzing a wavelength of inputted light; andan optical fiber for connecting the light emitting unit with the sensor unit, and connecting the detector with the sensor unit,wherein the light emitted from the light emitting unit is totally reflected in the optical fiber and irradiated to the sensor unit, and light reflected from the silver mirror of the sensor unit is irradiated to the detector.2. The aptasensor of claim 1 , wherein the gold nanorod is fixed to a core provided at an end of the optical fiber from which a cladding is peeled off through a self-assembly monolayer (SAM) scheme claim 1 , andthe aptamer to which a thiol group is adhered is attached to the gold nanorod.3. The aptasensor of claim 1 , wherein the aptamer is selectively bound to a target material.4. The aptasensor of claim 3 , wherein the target material is one of a ...

OPTOCHEMICAL SENSOR

The invention relates to an optochemical sensor comprising a polymer matrix which is applied to a substrate and which is doped with a luminescent colorant, the emissivity of which can be modified after excitation with electromagnetic radiation by substances to be detected such as gaseous or dissolved O, SO, HO, CO, nitrogen oxides and halogenated hydrocarbons, which polymer matrix forms a sensor layer that is also covered by an optical insulating and protective layer which can be permeated by the substance to be analysed. In the optochemical sensor, the sensor layer is formed from a layer which has an insular sensor element or a plurality of mutually separated sensor elements, the at least one sensor element being covered by a non-doped polymer matrix which chemically corresponds to the polymer matrix of the sensor layer. 1. An optochemical sensor including a polymer matrix applied on a substrate and doped with a luminescent dye whose emissivity upon excitation with electromagnetic radiation by substances to be detected , such as gaseous or dissolved O , SO , HO , CO , nitrogen oxides , halogenated hydrocarbons , is variable , and which forms a sensor layer , which is further covered by a protecting , supporting and/or insulating layer permeable for the substance to be analyzed , wherein the sensor layer is formed by a layer comprising at least one insular sensor element , which at least one insular sensor element is covered by an undoped polymer matrix chemically corresponding to the polymer matrix of the sensor layer , and that a further layer corresponding to the undoped polymer matrix is provided between the substrate and the layer comprising the at least one sensor element.2. The optochemical sensor according to claim 1 , wherein the sensor layer is formed by a layer comprising a plurality of mutually separate sensor elements claim 1 , which sensor elements are covered by an undoped polymer matrix chemically corresponding to the polymer matrix of the sensor ...

Methods and devices for performing an analytical measurement

A method of performing an analytical measurement based on a color formation reaction in an optical test strip by using a mobile device having a camera, a display and a position sensor. An optical test strip having a test field is provided. The camera captures a first image of the test field before a sample is applied and a second image after the sample is applied. An item of admissibility information, based on one or both of position sensor data and local position data, is determined. Admissibility is indicated when the position of the mobile device is substantially the same for capturing the first and the second image. When admissibility is indicated, an analytical measurement takes place. Further, a computer program, a computer-readable storage medium, a mobile device and a kit are disclosed.

Method and system for detecting target components by utilizing mobile terminal

A method and system for detecting a target component by using a mobile terminal, and a detection method for simultaneously screening multiple target objects. The method for detecting a target component by using a mobile terminal comprises: detecting a target component by using test strips ( 100 ) to obtain chromogenic test strips ( 100 ); arranging the test strips ( 100 ) around a same circle center at equal angles to obtain an arrangement ring of test strips ( 100 ), positioning identifiers being provided on an area outside the test strips ( 100 ) on the arrangement ring of the test strips ( 100 ); performing image acquisition on the arrangement ring of the test strips ( 100 ) by using a mobile terminal, and uploading an acquired image to a data processing center, correcting the acquired image according to the positioning identifiers; determining the positions of a personalized mark area and a result display area of each test strip ( 100 ) in the image; performing segmentation to obtain images of the personalized mark area and the result display area of each test strip ( 100 ); calculating a chromogenic result of the result display area, and obtaining a test result of the target component; and outputting the test result of the target component and displaying the test result on the mobile terminal.

UNIT FOR VALIDATING IN SITU DECONTAMINATION EFFECT AND DEVICE FOR FILTERING BIOLOGICALLY CONTAMINATED AIR TO WHICH THE UNIT IS APPLIED

The present invention discloses a unit for validating an in situ decontamination effect, including a connecting end. A left end of the connecting end is in communication with any space that needs gas decontamination. A right end of the connecting end is connected to a closed isolation damper. A right end of the closed isolation damper is connected to a hollow decontamination validation chamber. A sealing cover is sleeved over an outer wall of the decontamination validation chamber. A mesh cup is placed inside the decontamination validation chamber, and the mesh cup is used for placing a bioindicator. In addition, the present invention further discloses a device for filtering biologically contaminated air, including a unit for validating an in situ decontamination effect and a hollow box installed with a high efficiency particulate air (HEPA) filter. The unit for validating an in situ decontamination effect is in communication with the hollow box. In the present invention, an actual decontamination effect of the HEPA filter after gas decontamination can be validated reliably in time, thereby effectively preventing pathogenic microorganisms that exist on the surface of the HEPA filter from spreading to the external environment, avoiding polluting the external environment, and ensuring personal safety. 188. A unit for validating an in situ decontamination effect , comprising a connecting end () , wherein a left end of the connecting end () is in communication with any space that needs gas decontamination;{'b': 8', '9', '9', '10', '12', '10, 'a right end of the connecting end () is connected to a closed isolation damper (), a right end of the closed isolation damper () is connected to a hollow decontamination validation chamber (), and a sealing cover () is sleeved over an outer wall of the decontamination validation chamber (); and'}{'b': 10', '13, 'the decontamination validation chamber () is used for placing a bioindicator ().'}211101113. The device for filtering ...

Monoliths

Described herein are monoliths for processing fluid samples, and methods of making and using such monoliths.

DEVICES, COMPOSITIONS AND METHODS FOR USE IN DETECTING CONTAMINATING HEAVY METALS IN WATER SOURCES

The disclosure relates to electronic reader devices, detection compositions and methods for detecting heavy metals (e.g., lead) in water samples using a simple, rapid and highly selective immunoassay system, including lateral and upward flow assay systems. The immunoassay is designed to detect very low levels of a contaminating analyte such as lead at less than 1 ppb with high specificity and selectivity from any common water source (e.g., tap or drinking water). Advantageously, implementation of the assay requires no formal technical training or expensive equipment or reagents and is provided with a multi-use reader that can be used for 50 samples or more. The immunoassay sample collector systems are consumable (single use) and can be purchased in any desired quantity. Assay results are wirelessly transmitted from the reader using a SafeSpout-designed app., which provides important information based on the test results. 1. A method of detecting and quantitating an analyte in a sample comprising the steps of:a) obtaining a sample potentially containing an analyte of interest;b) transferring the sample to a sample collector pre-treating the sample to prepare the sample for detection and quantitation of the analyte;c) contacting the pre-treated sample with a test strip;d) assaying the pre-treated sample using the test strip to determine the concentration of the analyte in the pre-treated sample; ande) quantitating the concentration of the analyte, wherein the concentration of the analyte is measured qualitatively and quantitatively using the test strip.2. The method of claim 1 , wherein the detecting and quantitating of the analyte in the sample comprises an immunoassay test strip claim 1 , wherein a sample application area and a detection area are on a chromatographic immunoassay test strip claim 1 , and the test strip further comprises a sample pad claim 1 , wherein the pre-treated sample is applied to or first contacted with the test strip and a conjugate area or ...

DEVICE AND METHODS OF USING DEVICE FOR DETECTION OF HYPERAMMONEMIA

The present disclosure relates to a biosensor capable of measuring the total concentration of one or a plurality of ammonia or ammonium ions with the use of indophenol reagents in the presence of an ionomer. In some embodiments, the biosensor comprises a perflurinated membrane that comprises an ionomer in contact with an alkali buffer in a vessel configured to receive a sample, such as whole blood. The disclosure also relates to a method of detecting or quantifying the ammonia or ammonium ion concentration in whole blood in a point of care bio sensor without reliance on gas chromatography or any measurement that takes more than about twenty minutes. 1. A biosensor comprising:at least a first and second vessel;a fluid exchange opening positioned between the first and the second vessel;a membrane positioned across or over the fluid exchange opening; anda catalyst and/or a phenolic reagent in solid phase within the second vessel or within a conduit in fluid communication with the second vessel;wherein the membrane comprises an ionomer.2. The biosensor of further comprising a compound comprising a phenyl group in solid phase within the second vessel or within a conduit in fluid communication with the second vessel.3. The biosensor of claim 1 , wherein the catalyst is nitroprusside with a mass of from about 5.5 micrograms to about 7.8 micrograms.4. The biosensor of claim 2 , wherein the compound comprising a phenyl group has a mass of from about 75 micrograms to about 85 micrograms.5. The biosensor of claim 1 , wherein at least one conduit is in fluid communication with at least the first vessel claim 1 , the at least a first conduit configured to receive a fluid from a point external to the biosensor.6. The biosensor of claim 1 , wherein the first vessel or the second vessel: (i) comprises one or a combination of a hypohalite claim 1 , an alkali buffer claim 1 , and at least one: phenolic reagent or indophenol related compound; or (ii) are in fluid communication with a ...

Test device, assembly, and method

Analyte testing devices, assemblies, methods, operations, and systems are shown and described. In one embodiment, an apparatus to generate a test result from an assay when contacted with a sample includes a non-planar optics module to align the assay in an offset testing position. A modular interface assembly may support a motherboard and at least one non-planar optics module.

LATERAL FLOW BODILY FLUID TESTING SYSTEM AND METHOD

A lateral flow bodily fluid testing system is provided. The system comprises an application-analysable bodily fluid testing equipment () and an electronic device () comprising a camera () and one or more processors (). The one or more processors are configured to acquire image data of the application-analysable bodily fluid testing equipment with the camera of the electronic device, perform testing of bodily fluid applied to the application-analysable bodily fluid testing equipment using the image data to determine whether indicators of one or more bodily conditions are present in the applied bodily fluid, and output a result indicating whether the indicators of one or more bodily conditions are present in the applied bodily fluid. 132-. (canceled)33. A lateral flow bodily fluid testing system , the system comprising:an application-analysable bodily fluid testing equipment having a body portion, a QR code on the body portion, and one or more lateral flow testing strips combined with a first surface of the body portion, the one or more lateral flow strips being sensitive to indicators of bodily conditions in bodily fluid, and wherein the one or more lateral flow strips each comprise a fluid uptake region connected to an analysis region; and acquire image data of the bodily fluid testing equipment with the camera of the electronic device;', 'determine a position of the QR code in the image data;', 'determine positions of the analysis regions of the one or more lateral flow strips based upon determined position of the QR code;', 'perform testing of bodily fluid applied to the bodily fluid testing equipment, using the image data at the determined positions of the analysis regions, to determine whether indicators of one or more bodily conditions are present in the applied bodily fluid; and', 'output a result indicating whether the indicators of one or more bodily conditions are present in the applied bodily fluid., 'an electronic device comprising a camera and one or ...

Oxygenase-Based Biosensing Systems For Measurement Of Halogenated Alkene Concentrations

A biosensing system that measures the concentration of halogenated alkenes is disclosed. 1. A biosensing system that measures the concentration of a halogenated alkene in a solution , said biosensing system comprisinga first biocomponent that catalyzes the reaction of said halogenated alkene, anda second biocomponent that catalyzes the reaction of a halogenated alkene epoxide, anda transducer layer that luminesces, andwherein said transducer layer is part of an optode.2. A method for measuring the concentration of a halogenated alkene in a solution wherebya first biocomponent catalyzes the reaction of said halogenated alkene and oxygen, andwhereby a second biocomponent catalyzes the reaction of a halogenated alkene epoxide produced by said first biocomponent, andwhereby a transducer layer luminesces, andwhereby said transducer layer luminescence is altered by oxygen and/or hydrogen ions in said solution, andwhereby photons from the luminescence of said transducer layer enter into a fiber optic cable and are transmitted to a photomultiplier, andwhereby said photomultiplier produces an output signal that is coupled to an algorithm that transforms the signal generated by said photomultiplier into an output correlated to the concentration of said halogenated alkene in said solution.3. The method of wherein:said first biocomponent is selected from the group consisting of toluene ortho-monooxygenase, toluene ortho-monooxygenase-Green, toluene ortho-monooxygenase variant, and toluene dioxygenase;said second biocomponent is selected from the group consisting of epoxide hydrolase, glutathione synthetase, glutathione S-transferase and gamma-glutamylcysteine synthetase; andsaid transducer layer comprises a luminescent reagent selected from the group consisting of RuDPP and fluorescein.45.-. (canceled)6. The biosensing system ofwherein said first biocomponent catalyzes the reaction of said halogenated alkene and oxygen and said halogenated alkene epoxide is created by the ...

TEST KITS INCLUDING ACTIVATED MEDIATORS FOR DETECTING ANALYTES

Activated mediators for detecting predetermined analytes in a sample, as well as kits including testing surfaces incorporating an enzyme-activated mediator are disclosed. The enzyme-activated mediator may have a first color prior to the application of a sample to the portion of the testing surface including the enzyme-activated mediator. The enzyme-activated mediator is configured to undergo a detectable color change to a second color different from the first color in response to the sample applied to the testing surface including a predetermined analyte reactive with the enzyme-activated mediator. Methods for making the testing surfaces and using the testing surfaces to detect analytes are also disclosed. 1. A method for detecting one or more predetermined analytes in a sample , the method comprising providing at least one activated mediator configured to produce a detectable change upon reaction with the one or more predetermined analytes in the sample.2. The method of claim 1 , further comprising:combining one or more enzymes with one or more mediators to form an aqueous solution; andreacting the one or more enzymes with the one or more mediators to form an aqueous solution including the at least one activated mediator in radical form.3. The method of claim 2 , further comprising inactivating the one or more enzymes contained in the aqueous solution including the one or more mediators in radical form prior to further reaction.4. The method of claim 2 , further comprising separating the one or more enzymes contained in the aqueous solution including the one or more mediators in radical form from the aqueous solution.5. The method of claim 2 , further comprising drying the aqueous solution including the one or more mediators in radical form onto a powder carrier.6. The method of claim 2 , further comprising drying the aqueous solution including the one or more mediators in radical form into powder form.7. The method of claim 2 , further comprising incorporating the ...