Biological sample-processing apparatus having a door with space for receiving reagent tanks

A biological sample-processing apparatus has a sample-processing chamber, which has a door with space for receiving reagent tanks. The reagent supply tanks have conduits in fluid communication with reagent buffer tanks in the sample-processing chamber. The door has a pivot with a hollow interior. At least one conduit connects the reagent supply tanks to the reagent buffer tanks through the hollow interior of the pivot. The present invention provides a modification of the door of a biological sample-processing apparatus so that the door is equipped with reagent supply tanks that contain reagents for processing biological samples and that facilitate the operation of the processing and increase convenience, and further, enable more of the apparatuses to be allocated in the same space.

Apparatus for and method of processing biological samples

The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.

APPARATUS FOR THE AUTOMATIC PERFORMANCE OF IMMUNOHAEMATOLOGY ANALYSIS ON GEL CARDS

The apparatus has a containing body with a flat upper functional floor for containing receptacles of reagents, diluents and samples, as well as housings for gel cards and incubators for the same; a lower floor containing receptacles for washing liquids and the collection of waste and cards and for housing the fluid control and electronic control system; a series of longitudinal and transverse guides associated with the upper part of the apparatus, suitable for carrying in suspension the moving heads of the apparatus, the heads being movable on the transverse guides; two heads, respectively for perforation and pipetting and for the transport of gel cards; two centrifuges and a gel card reader; and a folding touch screen providing information and control. 1. An apparatus for automatic immunohaematological analysis on gel cards , wherein the apparatus comprises:a) a containing body with a flat functional upper floor for containing receptacles of reagents, diluents and samples, as well as housings for the gel cards and their incubators;b) a lower floor carrying receptacles for washing liquids and for collection of waste and cards, and for housing a fluidic and electronic control system;c) a set of longitudinal and transverse guides associated with an upper part of the apparatus, suitable for carrying in suspension moving heads of the apparatus, which are movable on the transverse guides;d) two heads, respectively for perforating and pipetting and for transporting the cards;e) two centrifuges and a gel card reader; andf) a folding information and control touch screen.2. The apparatus according to claim 1 , wherein the flat functional upper floor is comprised of a single working level for all tasks claim 1 , having on one of its sides elements relating to reagents claim 1 , diluents claim 1 , samples and a dilution well claim 1 , and on its other side card drawers claim 1 , accesses to centrifuges claim 1 , access to the card reader claim 1 , and access to a bin for scrap ...

LUMINOMETER APPARATUS

A luminometer apparatus includes, inside a light-shielded room, a container rack loaded with holding containers, a dispensation mechanism that dispenses a liquid, a rotary plate that turns, while holding a plurality of reaction containers which accommodate a mixture liquid of a sample and a luminescent reagent on a concentric annular plate, and is provided with a gap allowing the container rack to pass therethrough between at least a pair of adjacent ones of the reaction containers, and a photodetection unit that performs luminescence measurements. The light-shielded room has an insertion opening having a width allowing for insertion of the container rack and provided to be openable and closable. The rotary plate is provided with a region in which the container rack can be installed inside a region of passage of the reaction containers, when turning, and is provided to be turnable where the light-shielded room is in a closed state. 1. A luminometer apparatus comprising:inside a light-shielded room shielded from external light,a container rack that is loaded with holding containers, each discretely accommodating at least one selected from a sample and a luminescent reagent which produces a luminescent reaction when mixed with the sample;a dispensation mechanism that dispenses a liquid;a rotary plate that turns, while holding a plurality of reaction containers which accommodate a mixture liquid of the sample and the luminescent reagent on a concentric annular plate, and is provided with a gap allowing the container rack to pass therethrough between at least a pair of adjacent ones of the reaction containers; anda photodetection unit that is provided such that it can face through an opening of the rotary plate the bottom of a reaction container which is positioned above the opening and performs luminescence measurements in a state where the light-shielded room is closed,wherein the light-shielded room has an insertion opening having a width allowing for insertion of ...

AUTOMATED CELL PROCESSING SYSTEMS AND METHODS

Systems and methods for automated cell processing of biological samples, such as cells for use in cell therapy and regenerative medicine. Systems for automated processing of batches derived from biological samples comprise: a closed and sterile enclosure; a plurality of reagent containers; at least one reagent dispenser; a quality control module for analyzing at least one characteristic of a batch; a harvesting module; a robotic module; and a control unit (CU) communicatively coupled to the at least one reagent dispenser, the quality control module, the harvesting module and the robotic module for controlling the automatic processing of batches. The automatic processing may be executable without handling by a human operator. The system may be configured to automatically process the plurality of batches without cross-contamination between batches, e.g., under GMP conditions. 2. The system of claim 1 , further comprising a particle counter communicatively coupled to the CU for measuring a particle count inside the enclosure.3. The system of or claim 1 , further comprising:an air flow system for controlling an air pressure inside the enclosure to be greater than an air pressure outside the enclosure.4. The system of any one of to claim 1 , wherein the enclosure is at least a class 10 environment.5. The system of any one of to claim 1 , wherein:the enclosure is defined at least in part by a plurality of walls including a top wall, a first side wall and a second side wall extending opposite the first side wall;the enclosure has an air inlet port defined in one or more of the plurality of walls of the enclosure;the enclosure has an air outlet port defined in one or more of the plurality of walls of the enclosure,the air flow system being configured to direct air flow into the enclosure via the air inlet port and air flow out of the enclosure via the air outlet port,an air flow within the enclosure being laminar.6. The system of any one of to claim 1 , wherein the system ...

Instant Early Stage Disease Detection by Decoding Organic Compound Signatures

The present invention provides a process and method for the early detection and diagnosis of disease by reading and decoding volatile organic compounds (VOCs) for signatures associated with a specific disease. From its outset, each disease begins producing its own unique set of volatile organic compounds. For many diseases, this early-stage detection may be many months or years before noticeable symptoms. The VOC emissions when analyzed, result in a “signature” that identifies and distinguishes the developing, or at later stages, the developed disease. The device assays non-invasively obtained biosamples in real-time to output a VOC based signature that, when correlated with data in a disease signature library, identifies one or more diseases associated with the sample. 1. An analytical device comprising a detector unit capable of interfacing with an analytical unit ,said detector unit comprising a plurality of detection surfaces capable of interacting with an ambient vapor phase;said detector unit comprising an orifice for introducing a sample to be assayed;said detection surface comprising a nano-sensor element (NSE) layer between an input and an output;said input in contact with a base power source;said output in communication with at least one data collector;said NSE layer associated with a selection component with selection specificity for one or more compounds of interest;said selection component when in contact with or in close proximity to a target compound possibly present in said vapor phase selectively altering signal to said output; anda component for collecting said signal from said output.2. The device of wherein a bio-molecular detection cartridge comprises:i) said detection surface;ii) said input; andiii) said output.3. The device of wherein said plurality of detection surfaces comprise a plurality of nanosensor elements distributed amongst a plurality of groups claim 1 , at least one of said groups under control of a switch claim 1 , said switch ...

Apparatus for and Method of Processing Biological Samples

The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like.

Holder, a set of parts, and a method of manipulating holders of laboratory consumables

According to an example aspect of the present invention, there is provided a holder for disposable pipette tips, the holder comprising: two pairs of opposing lateral sidewalls, each sidewall comprises an outer surface, an inner surface, an upper edge and a lower edge, and two lateral edges; the sidewalls are joined to each other via their lateral edges; a plate comprising a matrix of openings, connected to the upper edges of the sidewalls; means for locking the holder on top of another holder to form a stack of holders; wherein the locking is configured to be released by applying a force to said means for locking from above the stack of holders. 2. The holder according to claim 1 , wherein said force comprises a vertically-directed input force from above the stack of holders.3. The holder according to claim 1 , wherein the holder comprises at least one release opening into which a release device can be inserted from above the stack of holders in order to release the locking.4. The holder according to claim 3 , wherein:said at least one release opening is located in a surface that is parallel with said plate comprising a matrix of openings, orsaid at least one release opening is located in the plate comprising a matrix of openings.5. The holder according to claim 1 , wherein the releasing of the locking only releases the topmost holder from the-remaining holders of the stack.6. The holder according to claim 1 , wherein the means for locking comprises at least one flexible or deformable tongue.7. The holder according to claim 1 , wherein the means for locking comprises a radially deformable hollow pin.8. The holder according to claim 1 , wherein the means for locking is detachable from and re-attachable to the holder.9. A set of parts comprising at least a first holder and a second holder for disposable pipette tips according to .10. The set of parts according to claim 9 , wherein the holders are locked to each other claim 9 , the first holder on top of the second ...

LOADING STATION

Disclosed herein are methods, devices, and systems for loading and retrieval of particles. In some embodiments, a loading station comprise a tray configured to receive a microwell array, a first magnet, a second magnet, and an actuation mechanism configured to cause movement of at least one of the first magnet and the second magnet. 1. A loading station comprising:a tray configured to receive a microwell array;a first magnet, the first magnet being movable between a first magnet active position in which the first magnet is positioned to exert a first magnetic force in a first direction on one or more magnetic particles positioned within the microwell array and a first magnet inactive position in which the first magnet is positioned to exert less magnetic force on the one or more magnetic particles positioned within the microwell array in comparison to the first magnet active position, wherein the first magnet is positioned inferior to the tray when the first magnet is in the first magnet active position;a second magnet, the second magnet being movable between a second magnet active position in which the second magnet is positioned to exert a second magnetic force in a second direction on the one or more magnetic particles positioned within the microwell array and a second magnet inactive position in which the second magnet is positioned to exert less magnetic force on the one or more magnetic particles positioned within the microwell array in comparison to the second magnet active position, wherein the second direction of the second magnetic force is different than the first direction of the first magnetic force; andan actuation mechanism configured to cause movement of at least one of the first magnet and the second magnet.2. The loading station of claim 1 , wherein the actuation mechanism comprises an actuator claim 1 , the actuator being movable between a plurality of different positions claim 1 , wherein at least some movements of the actuator cause movement of ...

Automatic analysis device

An automated analysis device is provided with a casing accommodating an analysis device. A cover is axially supported with freedom to pivot, between a closed position and an upwardly-open open position, about a support shaft provided at one side of the casing. A closing device is capable of inhibiting opening of the cover in the closed position, and is provided with a lock accepting means, which is a projecting portion that protrudes from a front surface of the cover toward the rear, a lock lever which is axially supported with freedom to pivot about a pivoting support shaft, and which pivots from the work surface in a direction approaching the lock accepting means to engage with the lock accepting means, thereby inhibiting opening of the cover, and a driving means for driving the lock lever. A safety cover can thus be locked securely.

AUTOMATIC ANALYSIS APPARATUS

A driving mechanism for moving a vessel having a disposal box placed thereon in a front-rear direction the same as an opening/closing direction of a drawer is provided lower than a bottom surface of the vessel. A first rail extended in a movement direction of an operating unit, a second rail extended in a movement direction of the vessel provided in the drawer, and toothed pulleys for rotating a toothed belt within a horizontal plane are arranged. The first rail, the second rail, and the toothed belt are placed side by side without overlapping with each other in a vertical direction. As a result, the operation of taking out the disposal box in which used sample dispensing tips or reaction vessels are accumulated is simple. 1. An automatic analysis apparatus , comprising:a housing which accommodates an analysis device;a vessel disposed at a predetermined position in the housing;an opening for taking the vessel into/from the housing, which is provided in the housing;an operating unit which is operated to take the vessel into/from the housing via the opening;a transport mechanism which transports the vessel from the predetermined position to a vessel takeout position along with the operation of the operating unit; anda speed change mechanism which reduces an operation amount of the operating unit as compared with a movement amount of the vessel from the predetermined position to the vessel takeout position,wherein a movement direction of the operating unit and a movement direction of the vessel are the same when the vessel is taken in/out,the transport mechanism includes:a first rail which slidably supports the housing and the operating unit and extends in the movement direction of the operating unit;a second rail which slidably supports the operating unit and the vessel and extends in the movement direction of the vessel;a belt which bridges across a pair of pulleys provided in the operating unit to be looped thereover;transmission means for transmitting the operation ...

BENCHTOP LABORATORY APPARATUS AUTOMATION SYSTEM

The Benchtop Laboratory Apparatus Automation System, hereafter referred to as BLAAS, is designed for automation of common laboratory benchtop devices such as pipette tip boxes, waste containers, sample tubes and trays, and reagent or solvent containers. The BLAAS consists of a microprocessor, sensor and physical actuator attached to the benchtop device. A user's hand approaching the device will be detected and the system will respond by opening the device, allowing hands-free access to the contents. After a short delay, the top closes again after the hand clears the device. A light will illuminate to indicate when the device is actively opening, and parameters like the speed of the movement, the stop positions of the servo and the time the device remains open can be adjusted. 1. A benchtop laboratory apparatus automated system comprising:a benchtop laboratory apparatus with a cover, wherein the laboratory apparatus is connected to an automated system;a power input into the automated system;a programmable control board, wherein the programmable control board controls the automated system;a sensor, wherein the sensor detects an operator's hand present near the apparatus;a physical actuator, wherein the physical actuator shifts between a first position and second position;a mechanical linkage, wherein the mechanical linkage links the shift in the physical actuator from the first position to the second position to the cover of the laboratory apparatus, andfurther wherein in the first position the cover of the laboratory apparatus is closed and in the second position the cover of the laboratory apparatus is open; andan electronic network, wherein the electronic network communicates between the sensor and the programmable control board and the physical actuator whenever the operator's hand is present near the apparatus,and wherein when the programmable control board receives a communication from the sensor that the operator's hand is present near the apparatus then the ...

Specimen conveyance device and specimen processing system

A connection unit connects one end of each of two processing systems and includes a processing unit for carrying out necessary processing on a specimen in a specimen container held by a specimen holding rack. The first and second processing systems each have an opening and closing part that can be opened and closed to expose an access surface for an operator. The connection unit is configured so as to connect the first and second processing systems in such a way that a distance along a horizontal plane from the access surface of the first processing system to the one end of the second processing system is longer than a distance by which the opening and closing part of the first processing system moves when opening and closing. Thus, various layouts resulting from the structure are possible within an inspection room without diminishing the ease of operation.

AUTOMATIC ANALYZER

An automatic analyzer keeps the inside of a reagent cooler that stores a reagent vessel clean. The automatic analyzer includes: a reagent cooler that stores a reagent vessel containing a reagent to be reacted with a sample at a predetermined temperature. A reagent vessel replacement unit includes an opening configured to put the reagent vessel into and take the regent vessel out of the reagent cooler, wherein the opening is opened and closed to replace the reagent vessel. A positive pressure unit positively pressurizes the inside of the reagent cooler with respect to a periphery of the reagent cooler when the opening is opened. 116.-. (canceled)17. An automatic analyzer that analyzes a sample , the automatic analyzer comprising:a reagent cooler that stores a reagent vessel containing a reagent to be reacted with a sample at a predetermined temperature;a reagent vessel replacement unit that includes an opening configured to put the reagent vessel into and take the regent vessel out of the reagent cooler, wherein the opening is opened and closed to replace the reagent vessel; anda positive pressure unit that positively pressurizes inside of the reagent cooler with respect to a periphery of the reagent cooler when the opening is opened, whereinthe positive pressure unit creates a negative pressure around the reagent cooler with respect to the inside of the reagent cooler.18. The automatic analyzer according to claim 17 , whereinthe positive pressure unit includes an air supply unit that takes air into the reagent cooler.19. The automatic analyzer according to claim 18 , whereinthe air supply unit controls an air supply amount in accordance with an opening degree of the opening.20. The automatic analyzer according to claim 18 , whereinthe air supply unit performs at least one of dehumidification, sterilization, dust removal and temperature adjustment on the air taken in.21. The automatic analyzer according to claim 18 , further comprising:a reagent dispensing unit that ...

Automated analyzer

An automatic analysis device is provided with a storage chamber for adjusting the temperature of and storing a container in which liquid is stored, an opening provided in a portion of the storage chamber, and a loader mechanism for bringing the container in and out of the storage chamber by moving the container through the opening, and is characterized in that the loader mechanism and storage chamber are closed by an elastic body. In the present invention, attaching a sealing member for sealing to an upper part from among overlapping parts makes it difficult for debris and dust to adhere to the sealing member and makes it possible to maintain the sealed state of a reagent storage chamber over a long period of time.

APPARATUS FOR AND METHOD OF PROCESSING BIOLOGICAL SAMPLES

The present invention provides systems, devices, apparatuses and methods for automated bioprocessing. Examples of protocols and bioprocessing procedures suitable for the present invention include but are not limited to: immunoprecipitation, chromatin immunoprecipitation, recombinant protein isolation, nucleic acid separation and isolation, protein labeling, separation and isolation, cell separation and isolation, food safety analysis and automatic bead based separation. In some embodiments, the invention provides automated systems, automated devices, automated cartridges and automated methods of western blot processing. Other embodiments include automated systems, automated devices, automated cartridges and automated methods for separation, preparation and purification of nucleic acids, such as DNA or RNA or fragments thereof, including plasmid DNA, genomic DNA, bacterial DNA, viral DNA and any other DNA, and for automated systems, automated devices, automated cartridges and automated methods for processing, separation and purification of proteins, peptides and the like. 130.-. (canceled)31. A bioprocessing cartridge comprising:a first bioprocessing chamber, wherein the first bioprocessing chamber includes a first solid support, and wherein the first solid support is configured to filter debris from cell lysate;a second bioprocessing chamber, wherein the second bioprocessing chamber includes a second solid support, and wherein the second solid support is configured to reversibly bind nucleic acids;a plurality of fluid channels in fluid communication with the first and second bioprocessing chambers; andone or more reagent reservoirs, wherein the one or more reagent reservoirs are in fluid communication with one or more of the first and second bioprocessing chambers.32. The bioprocessing cartridge of claim 31 , wherein the first solid support is a cell lysate clarification filter.33. The bioprocessing cartridge of claim 32 , wherein the cell lysate clarification ...

Safety light curtain to disable carousel rotation

A digital slide scanning apparatus includes a safety light curtain that operates to disable the motor that rotates the carousel when the presence of an object (e.g., the fingers of an operator) is detected within a predetermined area of the carousel. The light curtain also operates to disable the motor that rotates the carousel when an improperly positioned glass slide or slide rack is detected. The digital slide scanning apparatus also includes a multi-color status indicator for each rack slot that indicates the rack slot location of an improperly positioned glass slide or slide rack.

MICROFLUIDIC FLOW CONTROLLER, FLUID ANALYSIS APPARATUS, ANALYSIS MODULE AND METHODS

A microfluidic flow controller for receiving analyte fluid and calibration fluids wherein the flow controller is configured to switch between (i) an analysis mode in which analyte fluid is passed to an analysis module and (ii) a calibration mode in which the analyte fluid is passed to an alternative destination and calibration fluid is passed to the analysis module, thereby maintaining flow rate of analyte fluid from a source and maintaining a steady flow rate of fluid through the analysis module in both analysis mode and calibration mode. The flow controller may vary the ration of multiple calibration fluids during a calibration mode. Means for accurately positioning sensors within a flow conduit of the analysis module is also described. Sensors are also described for use with or without the microfluidic flow controller for the detection of metabolites and molecules. The sensors may or may not comprise enzymes and may be used with a sensing reagent, also described. 1. A microfluidic flow controller comprising:a fluid source connector for receiving analyte fluid;a first valve having: (i) an inlet coupled to the fluid source connector, (ii) a first outlet coupled to an analyte conduit for coupling to an analysis module; and (iii) a second outlet coupled to a drain conduit;a second valve coupled to a calibration fluid source inlet and having an outlet coupled to the analyte conduit; a) switch the first valve between: (i) an analysis mode in which the inlet is fluidly coupled to the first outlet, and (ii) a divert mode in which the inlet is fluidly coupled to the second outlet; and', 'b) switch the second valve between (i) a standby mode in which delivery of calibration fluid to the analyte conduit is blocked and (ii) a calibration mode in which the valve is configured to deliver calibration fluid to the analyte conduit,, 'a controller configured to substantially simultaneouslythe flow controller being thereby configured to maintain a steady flow rate of fluid through ...

AUTOMATED CELL PROCESSING SYSTEMS AND METHODS

A system for automated processing of a plurality of batches, each batch being derived from one biological sample, the system comprising an enclosure which can be closed and sterilized, each batch of the plurality of batches comprising one or more cell processing container; a plurality of reagent containers for holding reagents within the enclosure; at least one reagent dispenser within the enclosure for dispensing reagents during said automated processing; a quality control system within the enclosure for analyzing at least one characteristic of a batch during said automated processing; a harvester within the enclosure for harvesting batches; a robotic system within the enclosure, configured for transporting cell processing containers, decapping or otherwise opening cell processing containers, pipetting reagents or liquids from cell processing containers, and aspirating liquids from cell processing containers, during said automated processing; a tracker for electronically tracking the plurality of batches after its introduction to the enclosure; and a control unit (CU) communicatively coupled to the at least one reagent dispenser, the quality control system, the harvester, the robotic system and the tracker for controlling said automatic processing of said batches. 1. A system for automated processing of a plurality of batches , each batch being derived from one biological sample , the system comprising:an enclosure which can be closed and sterilized for the automated processing of the plurality of batches, each batch of the plurality of batches comprising one or more cell processing container;a plurality of reagent containers for holding reagents within the enclosure;at least one reagent dispenser within the enclosure for dispensing reagents during said automated processing;a quality control system within the enclosure for analyzing at least one characteristic of a batch during said automated processing;a harvester within the enclosure for harvesting batches;a ...

LABORATORY SYSTEMS FOR AUTOMATICALLY PROCESSING BIOLOGICAL SAMPLES, USE THEREOF AND METHOD FOR PROCESSING BIOLOGICAL SAMPLES BY MEANS OF SUCH A LABORATORY SYSTEM

The present invention describes a laboratory system for automatically processing at least one sample container containing a biological sample, the laboratory system comprising a housing; laboratory instrument units for executing processing steps on the biological sample; an input station configured to receive the sample container; a transport means for transport of the sample container from the input station to the laboratory instrument units, and further to an output station; a control unit for determining whether the sample and/or the container is in a condition to be processed by the laboratory instrument units; an input-output station providing an interface between the inside and the outside of the housing; and a workbench on the outside of the housing in front of the input-output station for an operator to be in the position to manipulate the sample and/or the container. Furthermore, the use of such a laboratory system as well as a method for processing a biological sample in a sample container by means of such a laboratory system is described. 1. A laboratory system for automatically processing at least one sample container containing a biological sample , the laboratory system being self-contained and comprising:a housing;one or more laboratory instrument units provided within the housing and configured to execute processing steps on said biological sample;a sample container input station configured to receive said sample container;a sample container output station configured to discharge said sample container after processing;a transport means configured to transport said sample container from the sample container input station to the one or more laboratory instrument units, and further to the sample container output station;a control unit for carrying out workflow control and error identification of the laboratory system, the control unit being configured to determine whether said biological sample and/or said sample container is in a condition to be ...

AUTOMATED SAMPLE STAINER AND A METHOD THEREOF

Embodiments of the present disclosure relates to a sample stainer for automatically staining samples with one or more reagents. The stainer comprises a trough base with predetermined pattern to hold one or more trough. Each trough comprises a plurality of compartments that is capable of being filled with one or more reagents required for staining samples. The stainer also comprises a slide holder for holding slides having sample collected from the users. The slide holder comprises a plurality of compartments, each compartment comprising one or more slots to hold the slides. The stainer further comprises a motion control unit that is configured to control the rotary motion of the trough base and linear motion of the slide holder during the staining process. The stainer also comprises a user interface configured to receive inputs including slide information and staining process related information from user to perform the staining of the sample. 1. A sample stainer , comprising:a trough base configured with a predetermined pattern to hold one or more trough, each trough comprising a plurality of compartments and each compartment is capable of being filled with one or more reagents required for staining one or more samples;a slide holder comprising a plurality of compartments, each compartment comprising one or more slots to hold one or more slides having sample collected from users;a motion control unit, coupled with the trough base and the slide holder, configured to control the rotary motion of the trough base and linear motion of the slide holder; and a processor coupled with the user interface; and', receive one or more command signals associated with the user inputs from the user interface;', 'actuate the motion control unit to control the rotary motion of the trough base and the linear motion of the slide holder in accordance with the one or more command signals thus received to perform the staining process; and', 'generate a notification signal indicative of ...

MULTI-TEST ASSAY SYSTEMS AND METHODS OF USING THE SAME

Embodiments disclosed herein are directed to multi-test assay systems for analyzing biological material and methods of using such multi-test assay systems. For example, the multi-test assay system can detect or identify one or more biological markers representative of or corresponding to an illness or disease. 1. A multi-test assay system for assaying a biological sample in an assay cartridge , the multi-test assay system comprising:one or more cartridge-locator elements sized and configured to position and orient the assay cartridge;one or more actuators positioned and configured to interface with and operate one or more corresponding assay controls on the assay cartridge;one or more light sources configured to illuminate one or more selected locations relative to the one or more cartridge-locator elements; and an image detector; and', 'a spectrograph configured to transform target light received from at least one of the one or more selected locations to dispersed-target light received at the image detector., 'a light analyzer assembly including2. The multi-test assay system of claim 1 , further comprising a controller operably coupled to the image detector claim 1 , the controller being configured to determine one or more wavelengths of a signal light within the target light claim 1 , the signal light being generated from the biological sample producing one or more selected wavelengths of light.3. The multi-test assay system of claim 2 , wherein the signal light is generated from a reaction in the biological sample.4. The multi-test assay system of claim 2 , wherein the controller is configured to correlate the determined one or more wavelengths of the signal light to at least one diagnosis.5. The multi-test assay system of claim 1 , further comprising:a base; anda tray connected to the base and movable relative thereto, the tray includes the one or more cartridge-locator elements and is sized and configured to accept the assay cartridge.6. The multi-test assay ...

Machine olfaction system and method

Methods, systems, and apparatus for a camera-enhanced multi-modal gas sensing apparatus including a camera configured to capture imaging data including at least a portion of a test environment including the gas sensing apparatus and an object of interest within the field of view of the camera, multiple gas sensors including a first type of gas sensor and a second type of gas sensor different from the first type of gas sensor which are each sensitive to a respective set of analytes, a housing configured to hold the multiple gas sensors, a gas inlet coupled to the housing and configured to expose the multiple gas sensors to a gas introduced from the test environment via the gas inlet, and a data processing apparatus in data communication with the multiple gas sensors and the camera.

AUTOMATED ANALYZER

To provide an automated analyzer with a built-in, user-friendly printer that can avoid contamination of printed paper of the printer by having a housing front wall provided in a recessed manner from a front end of a housing upper portion that has disposed thereon a sample disc , a reagent disc , a reaction disc, a sample dispensing mechanism, and a reagent dispensing mechanism, and by having a printer and a paper receptacle disposed on the housing front wall. The front end portion of the housing upper portion that projects beyond the housing front wall serves as eaves, thereby preventing a sample or a reagent that may be spilled on the housing upper portion from staining the printer or printing paper. 1. An automated analyzer comprising:a housing upper portion, the housing upper portion having disposed thereon a sample disc holding a plurality of samples, a reagent disc holding a plurality of types of reagents, a reaction disc holding a plurality of reaction cells, a sample dispensing mechanism for dispensing one of the samples into one of the reaction cells held on the reaction disc, and a reagent dispensing mechanism for dispending one of the reagents into the reaction cell held on the reaction disc;a housing front wall provided in a recessed manner from a front end of the housing upper portion; anda printer disposed on the housing front wall.2. The automated analyzer according to claim 1 , wherein the housing front wall has a paper receptacle disposed below the printer claim 1 , the paper receptacle being adapted to receive paper ejected from the printer.3. The automated analyzer according to claim 2 , further comprising a front door provided in an openable/closable manner claim 2 , the front door covering the housing front wall that has the printer and the paper receptacle disposed thereon claim 2 , wherein the front door has an opening that allows paper ejected from the printer to pass therethrough in a state in which the front door is closed.4. The automated ...

AUTOMATED ANALYZER

A panel holding base holding an operating panel disposed on a front-face side of a device upper part of an automated analyzer is inclined so as to rise from a lower end side on the front-face side toward an upper end side, and has a shape with increasingly narrower width from the lower end side toward the upper end side. As a result, increased operating panel operability and improved access to a sample disc or a reagent disc are simultaneously achieved. 1. An automated analyzer comprising:a housing having an upper surface on which there are disposed a sample disc holding a plurality of samples, a reagent disc holding a plurality of kinds of reagents, a reaction disc holding a plurality of reaction cells, a sample dispensing mechanism for dispensing the samples into the reaction cells held on the reaction disc, a reagent dispensing mechanism for dispensing the reagents into the reaction cells held on the reaction disc, and an operating panel; anda protective cover covering the upper surface of the housing in an openable/closable manner,wherein the operating panel is held on a panel holding base formed on a front-face side of the upper surface of the housing, andthe panel holding base is inclined so as to rise from a lower end side on the front-face side toward an upper end side, and has a shape with increasingly narrower width from the lower end side toward the upper end side.2. The automated analyzer according to claim 1 , wherein the protective cover includes a recessed portion in an end portion on the front-face side of the protective cover claim 1 , the recessed portion being withdrawn so as not to interfere with the operating panel held on the panel holding base when the protective cover is closed to cover the upper surface of the housing.3. The automated analyzer according to claim 2 , wherein the recessed portion of the protective cover is disposed so that the operating panel is positioned in a space within the recessed portion when the protective cover is ...

METHOD FOR NOTIFYING SAMPLE ANALYZER STATUS AND SAMPLE ANALYSIS SYSTEM

The present invention is to present a status notification method for the sample analyzer. The method includes a detection step for detecting the status of the sample analyzer for analyzing the sample, and an irradiating step for irradiating light upward in accordance with the detection step. 1. A method for notifying status of a sample analyzer , comprising:detecting status of the sample analyzer configured to analyze a sample; andirradiating light upward according to the detected status of the sample analyzer.2. The method according to claim 1 , whereinthe irradiating is performed when the detected status of the sample analyzer is predetermined status.3. The method according to claim 2 , whereinthe predetermined status includes status where a remaining amount of a reagent used for analyzing the sample is equal to or less than a predetermined amount.4. The method according to claim 1 , further comprising:stopping irradiating the light upward according to a change of the detected status of the sample analyzer.5. The method according to claim 4 , further comprisingemitting light laterally when the irradiating the light upward is stopped.6. The method according to claim 1 , wherein claim 1 ,the irradiating comprises irradiating the light of a color according to the detected status of the sample analyzer.7. The method according to claim 5 , whereinthe emitting comprises emitting the light of a color according to the detected status of the sample analyzer.8. The method according to claim 7 , whereina combination of the color of the light irradiated upward and the color of the light emitted laterally is changed according to the detected status of the sample analyzer.9. A sample analysis system comprising:a sample analyzer configured to analyze a sample; anda notification device comprising an irradiating unit configured to irradiate light upward, and a control unit configured to control the irradiating unit so as to irradiate the light upward according to status of the ...

AUTOMATIC ANALYZER

Position adjustment of an analysis module in an automatic analyzer is performed where a position adjustment instruction and a position where the position adjustment is actually performed are separated from each other. Position adjustment of probe mechanisms is performed by operating probe position adjustment switches formed on a housing of an analysis module. Where interlocking covers ( and ) for the module are present, the probe mechanisms of the module are stopped when the closed covers are opened. The position adjustment switches (A and B) and the position adjustment switch () are disposed to be separated from each other by a distance at which the switches cannot be operated by a single hand of an operator at the same time. Even when the cover () is opened by continuously pressing the position adjustment switch (), the probe mechanisms of the module are in an operable state for the position adjustment. 1. An automatic analyzer comprising:an analysis module including an a sample dispensing mechanism that aspirates a sample from a sample container and discharges the aspirated sample into a reaction container, a reagent dispensing mechanism that aspirates a reagent from a reagent container and discharges the aspirated reagent into the reaction container, and a photometer that measures the sample in the reaction container;first and second position adjustment switches that are disposed on a housing of the analysis module and are operated by an operator to adjust an operation position of either the sample dispensing mechanism or the reagent dispensing mechanism; anda position adjustment controller that drives the dispensing mechanism according to a position adjustment instruction from the first and second position adjustment switches, whereinthe first position adjustment switch and the second position adjustment switch are disposed to be separated from each other by a distance at which the first position adjustment switch and the second position adjustment switch are ...

RHEOMETER DOCKING STATION

A rheometer docking station and methods of use are provided. Certain of the systems and methods described herein are capable of docking a rheometer to a rheometer docking station. Certain of the systems and methods described herein are capable of locating a rheometer in one, two or three dimensions. 1. A rheometer docking station , comprising:a base;a docking body associated with the base, the docking body configured to receive a rheometer in a docking arrangement;a guide configured to guide the rheometer into an aligned position with the docking body, the guide including an entry having a funnel-shaped configuration to facilitate alignment of the rheometer with the docking body as the rheometer is received by the docking body; anda first locating component associated with the docking body, the first locating component being configured to mate with a second locating component of the rheometer to locate the rheometer in a docked position.2. The rheometer docking station of claim 1 , wherein the first locating component comprises a female component and the second locating component comprises a male component.3. The rheometer docking station of claim 1 , wherein the first locating component comprises an opening and the second locating component comprises a locating pin.4. The rheometer docking station of claim 1 , wherein the first locating component comprises a male component and the second locating component comprises a female component.5. The rheometer docking station of claim 1 , wherein the first locating component comprises a locating pin and the second locating component comprises an opening.6. The rheometer docking station of claim 1 , wherein the guide is attached to the base.7. The rheometer docking station of claim 1 , wherein the guide is positioned on the base.8. The rheometer docking station of claim 1 , further comprising a hood configured to receive and shield at least a portion of the rheometer.9. The rheometer docking station of claim 8 , wherein the ...

Automatic Analysis Device

In order to aspire to higher sensitivity in an automatic analysis device, it is important to prevent the mixing of dust and the like in a reaction part in which a sample and a reagent react. The present invention presents an automatic analysis device that is provided with a configuration for making the pressure inside a specific block in the device such as a reaction part, or inside the device become positive. By making the pressure become positive and forming an air flow that flows out from the inside of the reaction part or the device, it is possible to limit, to a certain amount or less, the amount of dust penetrating into the reaction part.

Sampling and Analytical Platform for the Remote Deployment of Sensors

An automated microprocessor-controlled monitoring system for the sampling and analysis of environmental contamination has independent multiple sample chambers . The sample chambers are populated with multiple analytical sensors , Multiple water level sensors located in the sample chambers are capable of determining the volume of sample, or standard, introduced into the individual sample chambers. The monitoring system is standardized with independent calibration modules L to support the analytical sensors in the sample chambers. This configuration of a monitoring system allows a “plug and play” configuration with all analytical sensors capable of standardization. The system anticipates the incorporation of future sensing methodologies through its flexible design. The disclosed system is capable of operating multiple pumps and measuring the water levels in multiple monitoring wells allows for the automated acquisition of data for slug, aquifer, and tracer tests. Other embodiments are described and illustrated. 1. A chemical monitoring system , comprising:(a) a central control board,(b) a plurality of chambers,(c) a plurality of sensors mounted M each of the said chambers,(d) means of delivering water samples to said chambers,(e) means of measuring a volume of said water samples delivered to each of the said chambers,(f) means of calibrating each of the said plurality of sensors mounted in each of the said chambers.2. Said chemical monitoring system of wherein said plurality of sensors may include pH electrode claim 1 , conductivity electrodes claim 1 , ORP electrodes claim 1 , dissolved oxygen electrodes claim 1 , ion-specific electrodes claim 1 , colorimetric detector or radiometric detector.3. Said chemical monitoring system of wherein the optical or conductivity detectors are used to measure said volume of water samples delivered to said chambers.4. Said chemical monitoring system of wherein said water samples are delivered to said chambers may include peristaltic ...

LOADING STATION

Disclosed herein are methods, devices, and systems for loading and retrieval of particles. In some embodiments, a loading station comprise a tray configured to receive a microwell array, a first magnet, a second magnet, and an actuation mechanism configured to cause movement of at least one of the first magnet and the second magnet. 116.-. (canceled)17. A method for collecting a plurality of barcode-bearing beads comprising: introducing a plurality of cells into a flowcell of a cartridge positioned within a loading station;introducing a plurality of magnetic barcode-bearing beads into the flowcell, wherein the flowcell comprises a plurality of microwells, wherein each microwell is dimensioned to receive at least one cell of the plurality of cells and at least one magnetic barcode-bearing bead of the plurality of magnetic barcode-bearing beads; moving a first magnet of the loading station to a position sufficient to exert a first magnetic force on at least some of the magnetic barcode-bearing beads positioned within the plurality of microwells in a first direction;moving a second magnet of the loading station to a position sufficient to exert a second magnetic force on at least some of the magnetic barcode-bearing beads positioned within the plurality of microwells in a second direction different than the first direction; andintroducing a fluid into the flowcell to cause at least some of the barcodebearing beads to flow through the flowcell.18. The method of claim 17 , wherein at least one of the first magnetic force and the second magnetic force are of a magnitude sufficient to prevent magnetic barcode-bearing beads on which the at least one of the first magnetic force and second magnetic force are exerted from flowing through the flowcell when the fluid is introduced into the flowcell.19. The method of claim 17 , wherein each of the first magnet and the second magnet are coupled to an actuation mechanism comprising an actuator.20. The method of claim 19 , wherein ...

Masking camera flash using reflectance

One embodiment provides systems and methods for masking the effects of a flash on an operator including: a drawer system configured to receive a tray comprising one or more laboratory containers, wherein upon receiving the tray, the drawer system centers the tray underneath an image capture device; a flash device configured to activate, based on said centering, to illuminate the one or more laboratory containers; and an image capture device configured to capture an illuminated image of the one or more laboratory containers.

Nucleic acid analysis apparatus, microchip for nucleic acid analysis, and method for mounting microchip in nucleic acid analysis apparatus

There is provided a nucleic acid analysis apparatus including a heating unit configured to apply heat by contacting a microchip, and a chip holding unit configured to change a position between a first holding position that holds the microchip in midair and a second holding position that holds the microchip in contact with the heating unit.

Sample measuring system and sample measuring method

A sample measuring system to reduce waste generated in a plurality of measurement units to be discarded to a common disposal unit while suppressing interference between measurement units due to waste disposal is provided. The sample measuring system includes a first measurement unit and a second measurement unit for measuring a sample, and a common disposal unit for storing waste generated from the first measurement unit and the second measurement unit. The first measurement unit includes a first disposal port connected to the disposal unit for discharging the waste generated in the first measurement unit. The second measurement unit includes a second disposal port connected to the disposal unit for discharging the waste generated in the second measurement unit.

APPARATUS FOR FACILITATING CHEMICAL ANALYSIS BASED ON COLOR PRINCIPLE

Disclosed herein is an apparatus for facilitating chemical analysis based on color principle. Accordingly, the apparatus may include a base located at the bottom of the apparatus. Further, the base may be composed of a rectilinear receptacle. Further, the apparatus may include an intermediate plate located above the base. Further, the apparatus may include a hood located atop the intermediate plate. Further, the hood may include a hood rectilinear receptacle. Further, the hood rectilinear receptacle may be secured to the intermediate plate using a fastening mechanism. Further, the apparatus may include a roundtable housed within the hood. Further, the apparatus may include a motion system passing through and engaging with the roundtable and the hood. Further, the apparatus may include an analysis system embedded into at least one board suspended within the base. Further, the analysis system facilitates automated chemical analysis of a plurality of extraneous vials. 1. An apparatus for facilitating chemical analysis based on color principle , the apparatus comprising:a base located at the bottom of the apparatus, wherein the base is composed of a rectilinear receptacle;an intermediate plate located above the base, wherein the intermediate plate is characterized by an intermediate plate perimeter, wherein the intermediate plate perimeter is congruent and complementing to a perimeter of the base;a hood located atop the intermediate plate, wherein the hood comprises a hood rectilinear receptacle, wherein the hood rectilinear receptacle is secured to the intermediate plate using a fastening mechanism;a roundtable housed within the hood, wherein the roundtable comprises a curvilinear structure optimized and weighted to reduce a strain of a high rotational velocity;a motion system passing through and engaging with the roundtable and the hood, wherein the motion system is driven by a motor arranged in a bearing assembly conducive to minimal frictional resistance to optimize ...

SAMPLE ANALYZER

A sample analyzer may include: a reagent table; a first reagent dispensing unit that dispenses a reagent from a reagent container in a first aspirating position into a reaction container; a second reagent dispensing unit that dispenses a reagent from a reagent container in a second aspirating position into a reaction container; a detection unit including detectors provided for holders that each hold a reaction container holding a measurement specimen containing a sample and the reagent dispensed by the first or the second reagent dispensing unit; and a controller that causes the reagent table to: transfer the reagent container, which holds the reagent relating to a measurement item for which the first reagent dispensing unit is used, to the first aspirating position; and transfer the reagent container, which holds the reagent relating to a measurement item for which the second reagent dispensing unit is used, to the second aspirating position. 1. A sample analyzer comprising:a reagent table on which reagent containers each holding a reagent are placed and that is configured to transfer the placed reagent containers to a first aspirating position and a second aspirating position;a first reagent dispensing unit that aspirates the reagent from the reagent container transferred to the first aspirating position, heats the aspirated reagent, and dispenses the heated reagent into a reaction container;a second reagent dispensing unit that aspirates the reagent from the reagent container transferred to the second aspirating position, heats the aspirated reagent, and dispenses the heated reagent into a reaction container; holders that hold reaction containers each holding a measurement specimen containing a sample and the reagent dispensed by the first reagent dispensing unit and reaction containers each holding a measurement specimen containing a sample and the reagent dispensed by the second reagent dispensing unit, and', 'detectors that are provided for the holders, ...

THERMAL MANAGEMENT IN THE CONTEXT OF AUTOMATED HISTOLOGICAL PROCESSING OF BIOLOGICAL SPECIMENS AND ASSOCIATED TECHNOLOGY

Methods and system capable of processing specimens carried by slides within an automated histological staining system. A slide carrier is moved toward and into a temperature-controlled internal environment of a stainer within the system. The slide carrier carries a first slide and a second slide, and the first and second slides can carry a first specimen and a second specimen, respectively. The first and second specimens are stained with at least one of a staining reagent and a counterstaining reagent while the first and second slides are within the internal environment and while an average temperature of the internal environment is greater than ambient temperature. The slide carrier can be moved out of the internal environment after staining one or both specimens. 1. A method for processing specimens carried by slides within an automated histological staining system , the method comprising:moving a slide carrier toward and into a temperature-controlled internal environment of a stainer within the system, the slide carrier carrying a first slide and a second slide, the first and second slides carrying a first specimen and a second specimen, respectively;staining the first and second specimens with at least one of a staining reagent and a counterstaining reagent while the first and second slides are within the internal environment and while an average temperature of the internal environment is greater than ambient temperature; andmoving the slide carrier out of the internal environment after staining the first and second specimens.2. The method of claim 1 , wherein:moving the slide carrier toward and into the internal environment includes robotically moving the slide carrier toward and into the internal environment; andmoving the slide carrier out of the internal environment includes robotically moving the slide carrier out of the internal environment.3. The method of claim 1 , wherein:the stainer includes a stainer housing within a main housing of the system; andthe ...

STATUS DISPLAYING SAMPLE CARRIERS

An automation system for an in vitro diagnostics environment includes a plurality of intelligent carriers that include onboard processing and navigation capabilities. To aid in operator handling of payloads and carriers, carriers include an electronically rewritable display on a surface visible to an operator. The display can include an LCD, E-ink, or other rewritable display and can utilize color, pattern, or text to convey status information of the payloads to the operator. 1. A carrier for use in an in vitro diagnostics environment comprising:a bracket for accepting one or more payloads; andat least one surface having an electronically rewritable display,wherein the carrier automatically updates the electronically rewritable display to provide a visual indication of status information regarding the one or more payloads.2. The carrier of claim 1 , wherein the status information can be updated wirelessly by a central controller.3. The carrier of claim 1 , wherein the one or more payloads comprises one or more sample containers and the carrier automatically updates the electronically rewritable display to provide a visual indication of status information regarding the one or more sample containers.4. The carrier of claim 1 , wherein the electronically rewritable display is a bi-stable display.5. The carrier of claim 1 , wherein the display can be updated by temporary application of power to electrical contacts on the carrier.6. The carrier of claim 1 , wherein the electronically rewritable display is a non-volatile display.7. The carrier of claim 1 , wherein the status information is conveyed by displaying a color on at least a portion of the electronically rewritable display.8. The carrier of claim 1 , wherein the status information is conveyed by displaying a pattern on at least a portion of the electronically rewritable display.9. The carrier of claim 8 , wherein the pattern comprises a blinking pattern.10. The carrier of claim 1 , wherein the status information ...

Nucleic acid extraction apparatus

The present invention provides a nucleic acid extraction instrument including a base, an outer housing connected with the base, and an instrumental main body positioned inside the outer housing and mounted to the base; and the instrumental main body includes an electrical power pack, a main control device, a first motor set, a second motor set, and a third motor set.

Device for detecting and/or analyzing bio-chip

In some aspects, the present disclosure provides a biochip detecting device that comprises a first shell ( 2 ) connect to a second shell ( 1 ), and a rotatable support frame ( 5 ) of biochip possessing a detecting zone that holds one or more biochips, and a detector ( 7 ).

UNIVERSAL DOCKING BAY AND DATA DOOR IN A FLUDIC ANALYSIS SYSTEM

An analytic system for carrying out a chemical assay, the system having a bay with an opening on one side, the bay of a size and shape to enclose a cartridge carrying sample material to be analyzed, one or more mechanisms within the bay through which the cartridge and or material within the cartridge is influenced, a door of a size to cover the opening, a securing mechanism associated with the bay and the door, by which the door is secured when closed. 1. (canceled)2. A method for performing biological sample testing , the method comprising:opening a door covering a bay of a selected analytical testing module of an analytical testing system, the analytical testing system comprising a plurality of analytical testing modules, each module having a bay with one or more mechanisms disposed therein that are configured to manipulate the biological sample container to perform analytical testing of the biological sample while the biological sample is maintained within the sample container, each module having a door operable between an open position to facilitate loading of the sample container in the bay and a closed position in which the door covers the opening of the bay during analytical testing;receiving, within the bay of the selected analytical testing module, a sample container containing a biological sample, wherein the biological sample is obtained from an individual patient;imaging, with an imaging device, a visible indicia on a surface of the sample container during loading of the sample container within the bay, the visible indicia being associated with the individual patient;based on the visible indicia, selecting an analytical sequence from a plurality of differing analytical sequences accessed by the system, the selected analytical sequence including operations for performing analytical testing on the biological sample in the sample container disposed within the bay of the selected module;performing analytical testing of the biological sample, with the ...

AUTOMATED METHOD AND SYSTEM FOR OBTAINING AND PREPARING MICROORGANISM SAMPLE FOR BOTH IDENTIFICATION AND ANTIBIOTIC SUSCEPTIBILITY TESTS

A method and automated apparatus for locating and selecting a colony of microorganisms on a culture dish and subjecting the obtained sample to a plurality of downstream tests including a test to identify the microorganism and a test to identify the susceptibility of the microorganism to antibiotics. The method includes the automated steps of locating and selecting a colony of microorganisms on a culture dish; obtaining a sample of the selected colony of microorganisms; preparing a suspension of a sample of microorganisms automatically by submerging the pick tool with the sample in a suspension, after which the pick tool is vibrated in at least the vertical direction to release the sample from the pick tool in the suspension. The turbidity of the suspension is monitored to ensure that the concentration of microorganism in suspension is sufficient so that the suspension is used a source for sample for both identification and antibiotic susceptibility of the microorganisms in the sample. The apparatus and system optionally provides for downstream processing of samples prepared for antibiotic susceptibility testing (AST). Such apparatus includes further processing after inoculation of an AST panel for the AST test. Such further processing includes capping and transferring inoculated panels to AST instrument. 1. A method for locating and selecting a colony of microorganisms on a culture dish and preparing a single sample suspension with the selected colony for multiple assays , wherein the method comprises the automated steps of:locating and selecting a colony of microorganisms on a culture dish;obtaining a sample of the selected colony of microorganisms;transferring the obtained sample into a container having an amount of a suspension medium, the container adapted to be received by a nephelometer;preparing a sample suspension by transferring at least a portion of the obtained sample into the suspension medium using a robotic pick tool;automatically obtaining an aliquot ...

SYSTEM AND METHOD FOR INCUBATION AND READING OF BIOLOGICAL CULTURES

The present invention describes an integrated incubator and image capture module that regulates the incubator atmosphere and obtains high-resolution digital images of sample specimens. The incubator has a cabinet type enclosure that enables the provision of a controlled environment to the contents of the incubator by having at least three ports on one face of the cabinet for the passage of sample containers. Additionally, an image capture module is located immediately adjacent to the incubator. In this regard, using at least three separate access/egress points for the sample containers streamlines operation of the system and enhances preservation of the incubator environment. Furthermore, locating the image capture module directly adjacent to the incubator reduces the amount of time a sample container is exposed to the external environment, thereby reducing the extent to which samples are exposed to potential contaminants and reducing the exchange of the lab and ambient atmospheres. 1. An integrated system for incubating and monitoring biological samples disposed in culture media , comprising:an incubator comprising a cabinet with multiple ports for automated receipt and removal of sample containers from the cabinet, wherein the cabinet includes a first port, a second port, and a third port;a first conveyor adapted to cooperate with the first port to receive sample containers containing biological samples inoculated with a sample for incubation,a second conveyor adapted to cooperate with the second port to remove sample containers from the cabinet, andwherein the third port cooperates with an image capture conveyor in an image capture module, wherein the image capture conveyor conveys sample containers from the cabinet to the image capture module for imaging and returns the sample containers to the cabinet after imaging.2. The system of claim 1 , wherein the third port further comprises:an ingress port adapted to receive sample containers in to the image capture ...

CIRCULAR TYPE CARTRIDGE ENABLING CENTRIFUGATION AND MODULAR AUTOMATIC ANALYZER USING THE SAME

A modular automatic analyzer using a circular type cartridge enabling centrifugation according to an exemplary embodiment of the present invention includes: a main body frame; an X-axis conveying unit which reciprocally moves in an X-axis direction with respect to the main body frame; a circular type cartridge accommodating housing which is installed with respect to the X-axis conveying unit so as to be reciprocally movable in the X-axis direction by the X-axis conveying unit, a single rotation drive unit which is installed in the circular type cartridge accommodating housing and is rotated step by step at a predetermined interval or rotated at a high speed for centrifugation, a circular type cartridge which is installed at an upper surface of the circular type cartridge accommodating housing so as to be rotatably connected to the rotation drive unit and has wells disposed to be spaced apart from each other at predetermined intervals in a circumferential direction of a disc-shaped main body, a tip lifting unit which picks up and moves a tip upward and downward, a measurement unit which measures a reaction in the well, a Z-axis drive unit which is provided with the tip lifting unit and the measurement unit and reciprocally operates in a Z-axis direction with respect to the main body frame, and a control unit C which controls an automatic immunity analyzer. 1. A modular automatic analyzer using a circular type cartridge enabling centrifugation , the modular automatic analyzer comprising:a main body frame;an X-axis conveying unit which reciprocally moves in an X-axis direction with respect to the main body frame;a circular type cartridge accommodating housing which is installed with respect to the X-axis conveying unit so as to be reciprocally movable in the X-axis direction by the X-axis conveying unit;a circular type cartridge which is installed at an upper side of the circular type cartridge accommodating housing, and has a centrifugation well for centrifugation of ...

Transporting apparatus, transporting method, and sample analysis system

A transporting apparatus transports a container configured to be used by a sample analysis apparatus or a rack holding the container. The transporting apparatus may include a robotic arm that transports the container or the rack between a first sample analysis apparatus and a second sample analysis apparatus; and a base that supports the robotic arm.

Microfluidic interrogation device

A portable, stand-alone microfluidic interrogation device including a microprocessor and a touch-screen display. The touch-screen display can receive one or more user input to select a particular particle interrogation procedure, and subsequently show interrogation results. A microfluidic path extending through the interrogation device includes alignment structure that defines an interrogation zone in which particles carried in a fluid are urged toward single-file travel. Operable alignment structure may define sheath-, or non-sheath fluid flow. Desirably, a portion of the alignment structure is removable from the device in a tool-free procedure. The device may operate under the Coulter principle, and/or detect Stokes' shift phenomena, and/or other optically-based signal(s).

DEVICES FOR AND METHODS OF PROCESSING BIOLOGICAL SAMPLES

The present disclosure provides devices, systems and methods for automated processing of biological samples. This disclosure provides a gel-frame cassette for an automated bioprocessing device, comprising: a gel-frame comprising: a front face, a back face, a frame comprising: two vertical side bars, each comprising a gel-frame holding hole, a top bar connecting the two vertical side bars, a bottom bar connecting the two vertical side bars and a hollow chamber enclosed by the two vertical side bars, the top bar, and the bottom bar; a front panel in contact with the front face of the gel-frame, the front panel comprising an expanded upper portion, and a back panel in contact with the back face of the gel-frame, the back panel comprising a horizontal opening at the bottom of the back panel. This disclosure also provides an automated bioprocessing machine that processes the gel-frame cassette or the gel-frame. 1. A gel-frame cassette for an automated bioprocessing device , comprising: a front face,', 'a back face,', two vertical side bars, each comprising a gel-frame holding hole,', 'a top bar connecting the two vertical side bars,', 'a bottom bar connecting the two vertical side bars and', 'a hollow chamber enclosed by the two vertical side bars, the top bar, and the bottom bar;, 'a frame comprising], 'a gel-frame comprisinga front panel in contact with the front face of the gel-frame, the front panel comprising an expanded upper portion, anda back panel in contact with the back face of the gel-frame, the back panel comprising a horizontal opening at the bottom of the back panel.2. The gel-frame cassette of claim 1 , further comprising a gel in the hollow chamber.3. The gel-frame cassette of claim 1 , wherein the gel forms covalent bonds with at least part of contacting surfaces on the two vertical side bars claim 1 , the top bar claim 1 , and the bottom bar.4. An automated bioprocessing device processing the gel-frame cassette of claim 2 , comprising:{'claim-ref': {'@ ...

Systems and methods for multi-analysis

Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

SYSTEMS AND METHODS FOR MULTI-ANALYSIS

Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample. 18-. (canceled)9. A method of performing three or more assays for detecting a plurality of analytes in a biological sample from a subject , comprising:providing a cartridge in a refrigerator condition,receiving the biological sample and the cartridge in a biological sample processing system, wherein: 'a plurality of components selected from the group consisting of: sample vessels, reagent units, assay units, liquid absorbing pad, and all reagents for performing the three or more assays; and', 'a) the cartridge comprises a sample handling system;', 'at least three assay units for performing the three or more assays to detect a plurality of analytes in the biological sample, and', 'at least two detection units;, 'b) the biological sample processing system comprisesheating at least one portion of the cartridge using a cartridge heater on the biological sample processing system;aliquoting at least a diluted portion of the sample into one of the components while the cartridge remains inside the biological sample processing system;decoupling one or more components from the cartridge while the cartridge remains inside the biological sample processing system to form one or more decoupled components;performing in the biological sample processing system the three or more assays, wherein the three or more assays are performed at least partially in parallel and comprises leaving one or more decouple components of the cartridge at a location in the device separate from the cartridge;detecting the ...

A method and apparatus for automatic staining of tissue samples

The present invention concerns an apparatus (1) for staining tissue samples, said apparatus (1) including a reagent section (2) or reagent containers (3); at least one staining section or tissue samples, a robotic head (22) or robotic element (20) that may move reagent to a predetermined tissue sample, said robotic element (20) being moveable above the reagent and the staining sections, a control element (85) that may manage a staining process, a 2-D optical sensor (86) to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element (86). By providing the robotic element (20) with a 2-D optical sensor (86), a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus. The optical sensor may be used to automatically identify the slides and the reagent containers present in the apparatus, just as the optical sensor may be used for checking if a slide is misplaced at or absent from a slide position, etc.

Systems and methods of sample processing and temperature control

Systems and methods of sample processing and temperature control are disclosed. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples. Some embodiments provides temperature control for sample carriers and processing materials, such as reagents. Corresponding systems and devices are disclosed, including sample processing systems (1) (Fig. 10), sample carrier temperature regulation systems, reagent temperature regulation systems, sample processing control systems, and temperature regulation devices. The present invention in particular applicability to the fields of immunohistochemistry, in-situ hybridization, fluorescent in-situ hybridization, special staining, such as special staining of histological samples, microarray sample processing, and cytology, as well as other chemical and biological applications.

Enhanced scheduling sample processing system and methods of biological slide processing

A sample processing system (101) that may be automated and methods are disclosed where sample(s) (198) are arranged on a carrier element (197) and a process operation control system (171) automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input (173). Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities (606) may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt (608) that may inform an operator of a need for a particular action in order to accomplish the desired tasks. Reversibility to proposed changes may be made available so that an operator may avoid having to activate proposed changes if they cause a processing result that is not acceptable.

Apparatus for automated processing biological samples

The present invention concerns an apparatus (1) for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by (7) applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus (1) comprising; a housing frame (4); at least one processing section for accommodating at least one slide (7), wherein the at least one processing section is provided within the housing (4); a hood cover protecting the at least one processing section in said housing (4); wherein the hood cover (40) completely encloses the processing section defining an interior space (120); and wherein the apparatus (1) further comprises climate control device (121) provided to control the environment within the interior space (120).

Method and apparatus for pretreatment of biological samples

The present invention concerns a method and an apparatus for automatic staining at least one biological sample, such as a tissue, accommodated on a carrier, e.g. a microscope slide (7) by applying a predetermined amount of reagents in a sequence according to a staining protocol, wherein at least one carrier is provided in a carrier rack assembly, wherein the carrier rack assembly comprises means for pretreatment of the biological sample on a carrier after the carrier is provided in the carrier rack assembly, said means for pretreatment of biological samples includes a tank (101) which is provided in the carrier rack assembly (6), a carrier rack (61); and means for pivoting the carriers (7) provided in the carrier rack (61) to a vertical position and means for immersing the vertical carrier (7v) into the tank (101). By pivoting the carriers (7) from a horizontal to a vertical position, an automated method and apparatus for carrying out the pretreatment in the automated staining apparatus is provided. This pivoting of carriers (7) ensures an appropriate orientation of the carriers for both the pretreatment and the staining processes.

Supply unit for continuous loading

The present invention relates to a system and method for continuous loading of consumables into an analyzer comprising a stacker unit which can be uncoupled from the transport system for transporting the consumables from the stacker to the analytical modules and within and/or between the analytical modules.

EQUIPMENT FOR THE CONTROL OF THE INDUSTRIAL CONTAMINATION OF INDUSTRIAL COMPONENTS

Equipment for the control of the industrial contamination of industrial components comprising at least one base frame; and an extraction unit/device/component of contaminating impurities from at least one industrial component, mounted on the base frame and provided with a washing unit/device/component of the industrial component by way of an operating fluid adapted to remove the contaminating impurities from said industrial component, the operating fluid mixing with the contaminating impurities to obtain an operating mixture following the washing of the industrial component; and a preparation unit/device/component of at least one analysis sample of the contaminating impurities removed from the industrial component starting from the operating mixture, wherein the equipment comprises an analysis unit/device/component of the analysis sample mounted on the base frame and adapted to detect at least one analytical data which is characteristic of the contaminating impurities.

Instrument docking apparatus, systems, and methods

An instrument docking apparatus is provided. The instrument docking apparatus includes a docking base, a guide track, a guide pin configured to ride in the guide track, one or more capture members, wherein each capture member has a capture recess, and one or more alignment pins are operable to be received in the capture recess to capture an instrument in a defined spatial position and orientation. Instrument docking systems and methods of aligning instruments are provided, as are other aspects.

全自动电化学发光免疫分析仪的检测装置

本发明公开一种全自动电化学发光免疫分析仪的检测装置，包括用于检测反应液的测量组件、外包装组件和用于控制测量组件温度的控温组件，控温组件设置于外包装组件外表面，测量组件避光设置于外包装组件内部并与所述控温组件内表面接触，测量组件包括测量池，测量池的上方设有用于读取荧光的光电倍增管PMT，测量池的外底面设有与之可贴合可分离的吸珠磁铁，测量池连接有进液管和出液管，进液管和出液管避光伸出于外包装组件；其有益效果是：通过外包装组件将测量组件完全包裹在里面，完全将测量组件形成一个封闭的整体，避免外界光子进入测量组件，消除了外界光子带来的光噪音污染。整个机构可靠性、密封性较高。

自动分析仪

本发明公开了一种用于分析样品的自动分析仪(100)。所述自动分析仪(100)包括：壳体(102)，所述壳体至少部分地封围至少一个分析仪器(104)；抽屉(106)，所述抽屉配置为装载有多个试剂容器(108)，其中所述抽屉(106)能够在缩回位置与伸出位置之间相对于所述壳体(102)沿纵向方向(110)移动，在所述缩回位置，所述抽屉(106)缩回到所述壳体(102)中，在所述伸出位置，所述抽屉(106)从所述壳体(102)中伸出，其中所述抽屉(106)限定所述试剂容器(108)至少在平行于所述纵向方向(110)的第一排(114)中的布置位置(112)；和第一检测器(116)，所述第一检测器与所述第一排(114)相关联并且配置为当所述试剂容器(108)被布置在所述第一排(114)中时在第一检测位置处识别所述试剂容器。

Sample analyzer

Automatic analytical apparatus

本发明提供实现高可靠性的试剂管理，减轻试剂交换等的作业所带来的操作人员的负担，并且在分析中不会发生试剂不足的情况，而使分析动作中断最少化的自动分析装置。自动分析装置具备：保管多个上述试剂容器的第1试剂保管机构；与第1试剂保管机构不同的、保管交换用的试剂容器的第2试剂保管机构；从第2试剂保管机构向第1试剂保管机构搬运试剂容器的搬运机构；收纳从第2试剂保管机构排出的试剂容器的收纳部，还具备以在从第2试剂保管机构向第1试剂保管机构搬运试剂容器之前，或者从第2试剂保管机构向收纳部排出试剂容器之前，由信息写入机构向信息记录介质写入试剂信息的方式进行控制的控制机构。

Blood coagulation analyzer

Automatic cytological processing system and method

提供了用于生物样品(例如用于细胞疗法和再生医学的细胞)的自动化细胞处理的系统和方法。用于来自生物样品的批次的自动化处理的系统包含：封闭且无菌的外壳；多个试剂容器；至少一个试剂分配器；用于分析批次的至少一种特征的质量控制模块；收获模块；机器人模块；和控制单元(CU)，所述控制单元(CU)通信地耦合到所述至少一个试剂分配器、所述质量控制模块、所述收获模块和所述机器人模块，用于控制批次的自动化处理。所述自动化处理可在没有人操作者操作的情况下执行。所述系统可以被配置为例如在GMP条件下自动化处理多个批次，而没有批次之间的交叉污染。

Apparatus and method for biochemical analysis

An apparatus for analyzing that performs a plurality of treatment operations includes a plurality of treatment units arranged in a vertical direction of the apparatus. The apparatus for analyzing also includes a conveying mechanism configured to convey a sample between the treatment units. The sample is delivered above or in the treatment units. A pipette chip is also delivered above or in the treatment units.

Device for measuring fluidity of concentrate

본 발명은 농축액의 유동성 측정 장치에 관한 것으로서, 특히 하우징(100)과; 상기 하우징(100) 내측에 구비되어 농축액을 자유 낙하시키는 토출부(200)와; 상기 하우징(100) 내측에 회동 가능하게 구비되며, 상기 토출부(200) 하부에 위치하여 자유 낙하된 상기 농축액을 하부로 이동할 수 있게 하는 측정부(300)와; 상기 측정부(300)의 측면을 따라 이동 가능하게 구비되어 상기 농축액의 이동거리와 시간을 감지하는 센서부(400)로 구성되어, 농축액의 유동성을 객관적으로 측정하여 제품군의 측정값에 대한 정확도를 향상시킴으로써 품질 관리 성능을 증대시키는 동시에 제품의 안전성을 높이고 소비자의 불만 발생을 저감시켜 상품성을 향상시키는데 효과가 있도록 하는 것이다. The present invention relates to an apparatus for measuring the fluidity of a concentrated liquid, A discharging unit 200 provided inside the housing 100 for free dropping the concentrated liquid; A measuring unit 300 rotatably installed inside the housing 100 to allow the concentrate to be moved downwardly and located below the discharging unit 200; And a sensor unit 400 provided movably along the side surface of the measuring unit 300 to sense the movement distance and time of the concentrate. The sensor unit 400 measures the fluidity of the concentrate objectively, Thereby enhancing the quality control performance, enhancing the safety of the product, reducing the incidence of complaints by the consumers, and improving the merchantability.

Method and system for pretreatment of tissue slides

The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.

Apparatus for automated processing biological samples

The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.

Enhanced scheduling sample processing system and methods of biological slide processing

A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173 . Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks. Reversibility to proposed changes may be made available so that an operator may avoid having to activate proposed changes if they cause a processing result that is not acceptable.

Method and system for pretreatment of tissue slides

The present invention concerns a method and an apparatus for automatic staining of at least one tissue sample accommodated on a slide by applying reagents. The system may include at least one slide provided in a slide rack, a fluid containment element, a slide holder, a vertical slide positioner to pivot the slides to a vertical position, and a slide immerser element to immerse the vertical slide into a fluid containment element or even a dip tank. By pivoting the slides from a horizontal to a vertical position, an automated method and apparatus for carrying out a pretreatment in an automated staining apparatus may be provided. The pivoting of slides may ensure an appropriate orientation of the slides for both the pretreatment and the staining processes.

Method and apparatus for automatic staining of tissue samples

The present invention concerns an apparatus for staining tissue samples, said apparatus including a reagent section or reagent containers; at least one staining section or tissue samples, a robotic head or robotic element that may move reagent to a predetermined tissue sample, said robotic element being moveable above the reagent and the staining sections, a control element that may manage a staining process, a 2-D optical sensor to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element. By providing the robotic element with a 2-D optical sensor, a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus. The optical sensor may be used to automatically identify the slides and the reagent containers present in the apparatus, just as the optical sensor may be used for checking if a slide is misplaced at or absent from a slide position, etc.

Information notification sample processing system and methods of biological slide processing

A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Enhanced scheduling sample processing system and methods of biological slide processing

A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173 . Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks. Reversibility to proposed changes may be made available so that an operator may avoid having to activate proposed changes if they cause a processing result that is not acceptable.

Isolated communication sample processing system and methods of biological slide processing

A sample processing system 101 that may be automated and methods are disclosed where a number of sample processing systems 101 , such as stainer, may be connected to a number of separate full function computers 181 through a stainer network 183 that may be isolated from other communication traffic. A network configuration may permit scalability and addressability so that additional sample processing systems 101 , additional separate full function computers 181 , and additional other devices such as label printers 200 may be easily added to the system. One or more remote information links 171 may be provided so that information transfer on a continuous or perhaps constant basis can be accommodated.

Information notification sample processing system and methods of biological slide processing

A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Information notification sample processing system and methods of biological slide processing

A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Apparatus for automated processing biological samples

The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.

Enhanced scheduling sample processing system and methods of biological slide processing

A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173 . Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks. Reversibility to proposed changes may be made available so that an operator may avoid having to activate proposed changes if they cause a processing result that is not acceptable.

Method and apparatus for automatic staining of tissue samples

The present invention concerns an apparatus ( 1 ) for staining tissue samples, said apparatus ( 1 ) including a reagent section ( 2 ) or reagent containers ( 3 ); at least one staining section or tissue samples, a robotic head ( 22 ) or robotic element ( 20 ) that may move reagent to a predetermined tissue sample, said robotic element ( 20 ) being moveable above the reagent and the staining sections, a control element ( 85 ) that may manage a staining process, a 2-D optical sensor ( 86 ) to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element ( 86 ). By providing the robotic element ( 20 ) with a 2-D optical sensor ( 86 ), a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus. The optical sensor may be used to automatically identify the slides and the reagent containers present in the apparatus, just as the optical sensor may be used for checking if a slide is misplaced at or absent from a slide position, etc.

Apparatus for automated processing biological samples

The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.

Systems and methods of sample processing and temperature control

Systems and methods of sample processing and temperature control are disclosed. The invention may especially relate to temperature control, and may in some embodiments be methods of temperature control of an automated sample processing system and methods of automated sample processing. Specifically, the present invention provides temperature control in relation to sample processing systems and methods of processing samples, and in some embodiments provides temperature control in relation to sample carriers and processing materials such as reagents. Corresponding systems and devices are disclosed, including sample processing systems ( 1 ), sample carrier temperature regulation systems ( 60 ), reagent temperature regulation systems, sample processing control systems, and temperature regulation devices, among other embodiments. Scientific fields to which the present invention may have particular applicability include immunohistochemistry, in-situ hybridization, fluorescent in-situ hybridization, special staining, such as special staining of histological samples, microarray sample processing, and cytology, as well as potentially other chemical and biological applications.

Information notification sample processing system and methods of biological slide processing

A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Enhanced scheduling sample processing system and methods of biological slide processing

A sample processing system 101 that may be automated and methods are disclosed where sample(s) 198 are arranged on a carrier element 197 and a process operation control system 171 automatically processes the sample(s) perhaps robotically according to an desired aggregation of event dictated by an input 173 . Alteration of an initial aggregated event topology may be accepted while the system is processing an initial aggregation and varied-parameter robotic control simulation functionalities 606 may be accomplished to determine an enhanced sequence for processing. Suggested operator actions may be displayed that might further enhance the scheduling of the altered aggregated event topology together with an automatic operator need prompt 608 that may inform an operator of a need for a particular action in order to accomplish the desired tasks. Reversibility to proposed changes may be made available so that an operator may avoid having to activate proposed changes if they cause a processing result that is not acceptable.

Method and apparatus for automatic staining of tissue samples

The present invention concerns an apparatus for staining tissue samples, said apparatus including a reagent section or reagent containers; at least one staining section or tissue samples, a robotic head or robotic element that may move reagent to a predetermined tissue sample, said robotic element being moveable above the reagent and the staining sections, a control element that may manage a staining process, a 2-D optical sensor to detect two-dimensional image data of a relevant property and that can feed the captured image data to the control element. By providing the robotic element with a 2-D optical sensor, a common image processor may be provided having multiple functions. By using a 2-D optical image processing system, the control system of the apparatus may easily be adapted to read various types of data presentations, just as actual images for sections of the apparatus may be identified in order to assess the condition of the apparatus. The optical sensor may be used to automatically identify the slides and the reagent containers present in the apparatus, just as the optical sensor may be used for checking if a slide is misplaced at or absent from a slide position, etc.

Information notification sample processing system and methods of biological slide processing

A sample processing system that may be automated and methods are disclosed where samples are arranged on a carrier element and a process operation control system automatically processes the samples perhaps robotically with an operationally-influential exteriorly-consequential information monitor or a data capture element. Significant process details as well as operationally-influential exteriorly-consequential information may be monitored and an automatic notice element may cause notification of a person at some display that may be remote. Various people may be notified, such as an administrator, a supplier, or a manufacturer of an opportunity for some action such as reagent reordering or the like. A simulated motion display may be included to “watch” simulated operation in real time or long after completion of the actual processing.

Thermal management in the context of automated histological processing of biological specimens and associated technology

Methods and system capable of processing specimens carried by slides within an automated histological staining system. A slide carrier is moved toward and into a temperature-controlled internal environment of a stainer within the system. The slide carrier carries a first slide and a second slide, and the first and second slides can carry a first specimen and a second specimen, respectively. The first and second specimens are stained with at least one of a staining reagent and a counterstaining reagent while the first and second slides are within the internal environment and while an average temperature of the internal environment is greater than ambient temperature. The slide carrier can be moved out of the internal environment after staining one or both specimens.

Automated Cell Handling Systems and Methods

세포 치료법 및 재생 의학에서 사용하기 위한 세포와 같은 생물학적 샘플의 자동화된 세포 처리를 위한 시스템 및 방법이 제공된다. 생물학적 샘플로부터 유래된 배치의 자동화된 처리를 위한 시스템은 폐쇄되고 멸균된 인클로저와; 다수의 시약 용기와; 적어도 하나의 시약 디스펜서와; 배치의 적어도 하나의 특성을 분석하기 위한 품질 관리 모듈과; 수확 모듈과; 로봇 모듈; 및 배치의 자동 처리를 제어하기 위해 적어도 하나의 시약 디스펜서, 품질 관리 모듈, 수확 모듈 및 로봇 모듈에 통신 가능하게 결합된 제어 장치(CU)를 포함한다. 자동화 처리는 인간 조작자에 의한 조작 없이 실행될 수 있다. 시스템은 배치 간의 교차 오염 없이, 예를 들어, GMP 조건 하에 다수의 배치를 자동으로 처리하도록 구성된다. Systems and methods are provided for automated cellular processing of biological samples, such as cells, for use in cell therapy and regenerative medicine. A system for automated processing of a batch derived from a biological sample comprises: a closed, sterile enclosure; a plurality of reagent vessels; at least one reagent dispenser; a quality control module for analyzing at least one characteristic of the batch; harvesting module; robot module; and a control unit (CU) communicatively coupled to the at least one reagent dispenser, quality control module, harvest module and robotic module to control the automated processing of the batch. The automated process can be executed without operation by a human operator. The system is configured to automatically process multiple batches, eg, under GMP conditions, without cross-contamination between batches.

Specimen analyzer

本发明提供一种样本分析装置，包括：试剂库，用于收纳试剂容器，并对所收纳的试剂容器进行冷却；及测定部件，用于用所述试剂库冷却后的试剂对样本进行测定；其中，所述试剂库包括：外壳，该外壳的上部能够开合；试剂容器台，配置在所述外壳内，且其位置与所述外壳的底部之间留有间隔，该试剂容器台用于放置试剂容器；第1构件，与所述试剂容器台上放置的试剂容器的侧面相对而设；及第2构件，设置在低于所述试剂容器台的位置，且其导热性比所述第1构件高。

Fluid handling device

FIELD: manufacturing technology.SUBSTANCE: present invention relates to a liquid handling device (1) comprising working platform (2) having a plurality of sockets (3) for arranging consumable products (100) and defining first portion (51) of working surface (50) of device (1), and feeding platform (4) for consumable products (100), defining second part (52) of working surface (50) and comprising at least one modular frame (40) provided with at least one holding frame (41) for consumable products (100), wherein modular frame (40) is movable relative to working platform (2) to allow attachment of retaining frame (41) to modular frame (40) and disconnection therefrom; retaining frame (41) has carrying container (42), allowing to stack consumable products (100) under working surface (50), and hole (43) on working surface (50), allowing to locate consumable products (100) on working surface (50).EFFECT: technical result is creation of a device for molecular biology applications intended for transfer of biological fluids using consumable products moved in an automatic way.13 cl, 6 dwg РОССИЙСКАЯ ФЕДЕРАЦИЯ (19) RU (11) (13) 2 724 312 C1 (51) МПК G01N 35/04 (2006.01) G01N 35/00 (2006.01) B01L 9/02 (2006.01) ФЕДЕРАЛЬНАЯ СЛУЖБА ПО ИНТЕЛЛЕКТУАЛЬНОЙ СОБСТВЕННОСТИ (12) ОПИСАНИЕ ИЗОБРЕТЕНИЯ К ПАТЕНТУ (52) СПК G01N 35/04 (2020.02); G01N 35/00 (2020.02); B01L 9/02 (2020.02) (21)(22) Заявка: 2019116372, 22.12.2017 (24) Дата начала отсчета срока действия патента: (73) Патентообладатель(и): Инпеко Холдинг Лтд. (MT) Дата регистрации: 22.06.2020 Приоритет(ы): (30) Конвенционный приоритет: 23.12.2016 IT 102016000130628 (45) Опубликовано: 22.06.2020 Бюл. № 18 (85) Дата начала рассмотрения заявки PCT на национальной фазе: 23.07.2019 (86) Заявка PCT: (87) Публикация заявки PCT: WO 2018/116261 (28.06.2018) C 1 C 1 IB 2017/058328 (22.12.2017) 2 7 2 4 3 1 2 Адрес для переписки: 191002, Санкт-Петербург, а/я 5 R U 2 7 2 4 3 1 2 (56) Список документов, цитированных в отчете о поиске: RU 2562572 ...

Electrochemical transducer for determining concentration of substances in solutions

A molecule-selective sensor has a hollow body (1) in the interior of which are disposed a sensing electrode (4) and a reference electrode (5) immersed in an electrolyte (2). The end of the hollow body (1) is closed by a proteinaceous or other natural membrane (7) which has a surface layer (6) carrying or containing a chemically immobilized enzyme. <IMAGE>

Method and apparatus for pretreatment of tissue slides

本发明涉及一种通过按照染色规程依次施加预定量的试剂，而对容纳在载体例如显微镜载玻片(7)上的至少一种生物样品进行自动染色的方法和装置，其中至少一个载体配备在载体轨道组件中，载体轨道组件包括在载体配备到载体轨道组件中之后，用于预处理载体上的生物样品的装置，所述用于预处理生物样品的装置包括配备在载体轨道组件(6)中的罐(101)；载体轨道(61)；以及用于将配备在载体轨道(61)中的载体(7)绕枢轴旋转到垂直位置的装置，和用于将垂直载体(7v)浸渍到罐(101)内的装置。通过将载体(7)从水平位置绕枢轴旋转到垂直位置，提供了一种在自动染色装置内完成预处理的自动方法和装置。载体(7)的绕枢轴旋转确保载体在预处理和染色过程中的适当取向。

Enzyme-linked immunosorbent assay apparatus having holding device for pipette gear

장치 이동 시 영점 조정 상태를 양호하게 계속 유지할 수 있는 피펫장비 고정용 디바이스를 갖는 체외진단장치가 개시된다. 본 발명에 의한 피펫장비 고정용 디바이스를 갖는 체외진단장치는 케이스 내부에 높이에 따라 복수개의 레이어로 구성요소가 배치될 수 있도록 설계된 체외진단장비에 있어서, 상기 복수개의 레이어 중에 최상층 레이어에는 3축방향으로 이동하면서 표적물질과 시약을 흡입 및 토출하는 멀티 피펫 장비가 구비되고, 상기 멀티 피펫 장비는 수평방향 이동을 위하여 가이드 레일 상부에 설치되어 직선 이동하도록 설치되되, 상기 가이드 레일에는 상기 멀티 피펫 장비를 소정 위치에서 구속하기 위한 구속 고정부를 포함한다. Disclosed is an in vitro diagnostic device having a device for fixing a pipette device capable of maintaining a satisfactory zero-adjustment state when the device is moved. In vitro diagnostic device having a device for fixing pipette equipment according to the present invention is an in vitro diagnostic device designed to allow components to be arranged in a plurality of layers according to the height inside the case, wherein the uppermost layer among the plurality of layers has a three-axis direction. A multi-pipette equipment for suctioning and discharging target substances and reagents while moving to is provided, and the multi-pipette equipment is installed on a guide rail for horizontal movement and is installed to move in a straight line, and the multi pipette equipment is provided on the guide rail. It includes a restraint fixing part for restraining at a predetermined position.

MODULAR DEVICE FOR ANALYSIS.

Conjunto de módulos para el montaje de un aparato de análisis para llevar a cabo un proceso analítico de etapas múltiples, que comprende: - como mínimo dos elementos portadores que pueden ser dispuestos adyacentes sobre el suelo, - como mínimo dos módulos de soporte que comprenden útiles adaptados para sostener los elementos a someter a análisis y cualesquiera elementos necesarios para el análisis, - soportes en cada uno de dichos elementos portadores para soportar cada uno de dichos dos o más módulos de soporte sobre un elemento portador, - un módulo de transferencia diseñado para transferir elementos desde una posición a otra, - puntos portadores ("carrier spots") sobre elementos portadores para soportar el módulo de transferencia sobre elementos portadores y medios para fijar de modo adicional el módulo de transferencia a los elementos portadores, caracterizándose dicho conjunto de módulos porque los soportes para soportar los módulos de soporte sobre los elementos portadores están dispuestos de manera que los módulos de soporte se encuentran o bien fijados de manera firme a los elementos portadores o sueltos pero soportados todavía por los elementos portadores con intermedio de los soportes cuando dicha fijación firme es desmontada y porque los módulos de soporte y el módulo de transferencia comprenden elementos de acoplamiento integrales de manera correspondiente para posicionar de forma exacta y conectar de manera firme dichos elementos de soporte con respecto al mencionado módulo de transferencia. Assembly of modules for the assembly of an analysis apparatus for carrying out a multi-stage analytical process, comprising: - at least two carrier elements that can be arranged adjacent to the ground, - at least two support modules that comprise useful adapted to support the elements to be subjected to analysis and any elements necessary for the analysis, - supports in each of said carrier elements to support each of said two or more support modules on a ...

Systems and methods for multi-analysis

Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.

Heat-preservation shell for analyzer

本发明涉及一种用于分析仪的保温壳，所述保温壳的壳壁中嵌设有用于输送液体的至少一条液体通道。液体通道嵌设在保温壳的壳壁中，一方面，在液体通道中输送或停留的液体受到保温壳的保温作用，使在液体通道中传输或停留的液体保持预设温度，避免了外界环境温度对传输中的液体的影响；另一方面，有效的利用了保温壳的壳壁的空间，避免各种液体管路错综复杂的分布在保温壳内部或外部，增加了空间利用率。所述保温壳在样本分析装置技术领域具有极高的应用价值。

Insulation cladding for analyzer

本发明涉及一种用于分析仪的保温壳，所述保温壳的壳壁中嵌设有用于输送液体的至少一条液体通道。液体通道嵌设在保温壳的壳壁中，一方面，在液体通道中输送或停留的液体受到保温壳的保温作用，使在液体通道中传输或停留的液体保持预设温度，避免了外界环境温度对传输中的液体的影响；另一方面，有效的利用了保温壳的壳壁的空间，避免各种液体管路错综复杂的分布在保温壳内部或外部，增加了空间利用率。所述保温壳在样本分析装置技术领域具有极高的应用价值。

Environmental control solution for clinical analyzer module

一种用于在临床分析仪模块中使用的环境控制系统，包括上层环境子系统，所述上层环境子系统包括远场传感器、一个或多个加热器、一个或多个脊柱冷却风扇以及一个或多个直列式流体热交换器。远场传感器被配置成获取上层环境子系统中的环境温度的测量结果。加热器被配置成基于来自远场传感器的环境温度的测量结果来产生热气流。脊柱冷却风扇被配置成基于来自远场传感器的环境温度的测量结果以将来自加热器的热气流与冷却气流混合的方式来操作。直列式流体热交换器被配置成将在临床分析仪模块上执行的反应中使用的流体加热到恒定温度。

Integrated modular structure and equipment for thrombus elasticity and blood coagulation analysis

本发明属于血样检测技术领域，公开了一种血栓弹力和凝血分析的一体式模块结构以及设备，包括承载体、用于对第一待测样品进行凝血常规检测的凝血分析模块、用于对第二待测样品进行血栓弹力图检测的血栓弹力模块和样本转移模块；样本转移模块用于将第一待测样品和第二待测样品分别传输至凝血分析模块以及血栓弹力模块进行检测。本发明，实现双项目检测，提高检测效率以及便捷度；提高了在待测样本在双检测模块、试管中的转移效率，相应提高检测效率；能同时提供血栓弹力模块所需要的第二待测样品，以及凝血分析模块所需要的第一待测样品，避免病人、患者需要抽取两管血样。

Device for measuring fluidity of concentrate

본 발명은 농축액의 유동성 측정 장치에 관한 것으로서, 특히 하우징(100)과; 상기 하우징(100) 내측에 구비되어 농축액을 자유 낙하시키는 토출부(200)와; 상기 하우징(100) 내측에 회동 가능하게 구비되며, 상기 토출부(200) 하부에 위치하여 자유 낙하된 상기 농축액을 하부로 이동할 수 있게 하는 측정부(300)와; 상기 측정부(300)의 측면을 따라 이동 가능하게 구비되어 상기 농축액의 이동거리와 시간을 감지하는 센서부(400)로 구성되어, 농축액의 유동성을 객관적으로 측정하여 제품군의 측정값에 대한 정확도를 향상시킴으로써 품질 관리 성능을 증대시키는 동시에 제품의 안전성을 높이고 소비자의 불만 발생을 저감시켜 상품성을 향상시키는데 효과가 있도록 하는 것이다.

Installation of analytical apparatus

本发明公开一种待安装在诊断实验室的大致水平表面(10)上的分析仪器(100、100'、100″)。仪器(100、100'、100″)包括底侧(20、20')和上工作侧(40、40')，底侧(20、20')附接有用于在表面(10)上滚动仪器(100、100'、100″)的至少三个脚轮(31、32、33、34)和至少两个支脚(35、36)。脚轮(31、32、33、34)具有固定高度，并且至少一个脚轮(34)比其它脚轮(31、32、33)高，因而当仪器(100、100'、100″)在表面(10)上滚动时，该仪器处于不平衡状态。至少两个支脚(35、36)的高度分别可调，从而在调节支脚(35、36)的高度时，上工作侧(40、40')被调平，并且仪器(100、100'、100″)安置在至少两个支脚(35、36)和高的脚轮(34)上。本发明还公开一种包括分析仪器(100、100'和100″)的分析系统(300、400)，以及一种安装分析仪器(100、100'、100″)和系统(300、400)的方法。

Sliding type replaceable fluid analysis chamber module

The present invention provides a fluid analysis chamber module capable of replacing an analysis element in a sliding method. The fluid analysis chamber module comprises a middle body, an upper body and a lower body, wherein the upper body and the lower body may rotate to come in contact with upper and lower surfaces of the middle body or to escape from a contact state. The middle body provides a chamber hole on which a tray with the analysis element seated thereon may be mounted. In addition, a tray storage hole is provided on a front end surface of the middle body such that the tray is mounted on the chamber hole through the storage hole. When the upper body and the lower body rotate and come in contact with the upper and lower surfaces of the middle body, the chamber hole is closed, a supply line and a discharge line of a fluid are closed, and a pogo pin for supplying power and transferring signals is connected to an electrode of the analysis element.